CN104815169A - Traditional Chinese medicine emulsifiable paste for treating chilblain and preparation method of traditional Chinese medicine emulsifiable paste - Google Patents

Traditional Chinese medicine emulsifiable paste for treating chilblain and preparation method of traditional Chinese medicine emulsifiable paste Download PDF

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CN104815169A
CN104815169A CN201510275515.7A CN201510275515A CN104815169A CN 104815169 A CN104815169 A CN 104815169A CN 201510275515 A CN201510275515 A CN 201510275515A CN 104815169 A CN104815169 A CN 104815169A
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folium
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王芬
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Qingdao Haizhixing Biotechnology Co Ltd
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Qingdao Haizhixing Biotechnology Co Ltd
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Abstract

The invention discloses a traditional Chinese medicine emulsifiable paste for treating chilblain. The active ingredients of the traditional Chinese medicine emulsifiable paste is prepared from the following raw materials: parslane herb, castor leaf, dahurian patrinia herb, leaf of alderleaf sida, herb of ciliate falsepimpernel, stem of linden viburnum, Japanese thistle herbor root, snake slough, Japanese ampelopsis root, pepper leaf, root of longstalk condorvine, earthworm, greater celandine herb, rhizome of tendrilleaf solomonseal, common cnidium fruit, root of common embelia, belveder fruit, leaf of betel pepper, leaf of snake sansevieria, himalayan teasel root, sweet-scented osmanthus, Arabian jasmine flower, aloe, liquorice root, wool grease and beewax. The traditional Chinese medicine emulsifiable paste has the effects of clearing away heat and toxic substances, removing stasis, diminishing swelling, promoting blood circulation to remove meridian obstruction, killing bacteria, removing necrotic tissue and promoting granulation; due to the intercoordination of the various medicinal materials, the various medicinal materials can be absorbed by skin; the traditional Chinese medicine emulsifiable paste is high in adhesive force, stable in properties and lasting in action; besides, the emulsifiable paste contains a plurality of aromatic alcohols and vitamin E, and has the effect of nourishing the skin.

Description

A kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain and preparation method thereof.
Background technology
Chilblain is common in winter, and due to local skin erythema, the tumidus infringement repeatedly that very cold causes, vesicle, ulcer can appear in severe patient, and the course of disease is slow, and weather turns warm rear spontaneous recovery, easily recurs.Cold is the main cause of chilblain morbidity.Its pathogenic factor be the skin of chilblain patient when running into cold (0 ~ 10 DEG C), the moist or changes in temperature sudden turn of events, local small artery shrinks, arteries paralysis of a specified duration and expanding, venous congestion, and local blood circulation is bad and fall ill.In addition, the factor such as humidity of skin, tip blood capillary deformity, autonomic nerve dysfunction, malnutrition, dyshormonia of patient self also may participate in morbidity.Lack the generation that the factors such as motion, acrohyperhidrosis humidity, footgear tension and long-term outdoor low operating temperatures all can cause chilblain.
Chilblain is apt to occur in early winter, early spring, and with child, women and peripheral blood circulation, bad person is common, the performances such as these patients often send out cool with acral body skin, acrocyanosis, hyperhidrosis.Skin lesion is apt to occur in the places such as finger, the back of the hand, face, auricle, toes, sufficient edge, heel, the distribution of normal both sides.Common infringement is the edematous erythema of the congestive dark violet redness protuberance of limitation, and indefinite border, edge is cerise, and surface is nervous glossy, and matter is soft.Local pressing can be faded, and goes to press rear redness to recover gradually.Can there is vesicle in severe patient, break and form rotten to the corn or ulcer, retain pigmentation or atrophic scar more afterwards.Gargalesthesia is obvious, aggravates after heated, pain after festering.Usual companion's pruritus or burn feeling, predilection site is finger, toes, heel, thigh, nose and ear.
At present, the method for the treatment of chilblain is a lot, though the medicine of existing treatment chilblain has certain curative effect, onset is slower, therapeutic effect is poor, local excitation is comparatively large, can not subside a swelling at short notice, mostly there is the deficiency that the course for the treatment of is long, curative effect is slow after using, and there is no significant sterilization effect and effect, especially can not thoroughly effect a radical cure for the chilblain of festering and obstinate chilblain, cure rate is lower, and curative effect is more undesirable.
Summary of the invention
The object of this invention is to provide a kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain and preparation method thereof, this traditional Chinese medicine emulsifiable paste has that heat clearing away is drawn out pus by applying a plaster to the affected part, removing blood stasis to reduce swelling, promoting blood circulation to remove obstruction in the collateral, Pesticidal and sterilizing, the necrotic tissue and promoting muscle growing that disappears effect, all medicines are coordinated mutually, all medicines can be absorbed by the skin rapidly, strong adhesion, stable in properties, persistent.
In order to solve the problem, technical scheme provided by the invention is:
A kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 20-40 part, Folium Ricini 20-40 part, Herba Patriniae 15-35 part, Folium sidae alnifoliae 10-30 part, alpine yarrow 8-20 part, Caulis Viburni Dilatati 8-20 part, Radix Cirsii Japonici 6-18 part, Periostracum Serpentis 6-12 part, Radix Ampelopsis 10-20 part, Folium Capsici 10-20 part, Radix Marsdeniae Longipedis 8-14 part, Pheretima 6-12 part, Herba Chelidonii 6-10 part, Rhizoma Polygonati Cirrhifolii 6-12 part, Fructus Cnidii 8-16 part, Radix embeliae laetae 6-10 part, Fructus Kochiae 4-10 part, Folium piperis betlis 8-12 part, Folium Sansevieriae Trifasclatae 6-12 part, Radix Dipsaci 6-14 part, Flos Osmanthi Fragrantis 8-18 part, Flos Jasmini Sambac 8-18 part, Aloe 8-16 part, Radix Glycyrrhizae 10-20 part, lanoline 50-70 part, Cera Flava 60-80 part.
Further, a kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 25-35 part, Folium Ricini 25-35 part, Herba Patriniae 20-30 part, Folium sidae alnifoliae 15-25 part, alpine yarrow 10-18 part, Caulis Viburni Dilatati 12-16 part, Radix Cirsii Japonici 10-14 part, Periostracum Serpentis 8-10 part, Radix Ampelopsis 12-18 part, Folium Capsici 12-18 part, Radix Marsdeniae Longipedis 10-12 part, Pheretima 8-10 part, Herba Chelidonii 7-9 part, Rhizoma Polygonati Cirrhifolii 8-10 part, Fructus Cnidii 10-14 part, Radix embeliae laetae 7-9 part, Fructus Kochiae 6-8 part, Folium piperis betlis 9-11 part, Folium Sansevieriae Trifasclatae 8-10 part, Radix Dipsaci 8-12 part, Flos Osmanthi Fragrantis 10-16 part, Flos Jasmini Sambac 10-16 part, Aloe 10-14 part, Radix Glycyrrhizae 12-18 part, lanoline 55-65 part, Cera Flava 65-75 part.
Further, a kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 30 parts, Folium Ricini 30 parts, Herba Patriniae 25 parts, Folium sidae alnifoliae 20 parts, alpine yarrow 14 parts, Caulis Viburni Dilatati 14 parts, Radix Cirsii Japonici 12 parts, Periostracum Serpentis 9 parts, Radix Ampelopsis 15 parts, Folium Capsici 15 parts, Radix Marsdeniae Longipedis 11 parts, Pheretima 9 parts, Herba Chelidonii 8 parts, Rhizoma Polygonati Cirrhifolii 9 parts, Fructus Cnidii 12 parts, Radix embeliae laetae 8 parts, the Fructus Kochiae 7 parts, Folium piperis betlis 10 parts, Folium Sansevieriae Trifasclatae 9 parts, Radix Dipsaci 10 parts, Flos Osmanthi Fragrantis 13 parts, Flos Jasmini Sambac 13 parts, Aloe 12 parts, 15 parts, Radix Glycyrrhizae, lanoline 60 parts, 70 parts, Cera Flava.
The present invention also provides the preparation method of the traditional Chinese medicine emulsifiable paste of described treatment chilblain, comprises the following steps:
(1) by Herba Portulacae, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 3-5 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 3-5 times of soak by water 1-2h, filter, filtrate is condensed into the lixiviate cream II of 1.20-1.25 when relative density is 50 DEG C;
(3) after Periostracum Serpentis wine being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
Using method: be coated with by traditional Chinese herb medicine of the present invention and put on the skin in affected part, being coated with and putting thickness on the skin is 0.5mm, every day 2 times, sooner or later respectively once.
Pharmacological action:
Herba Portulacae: medicinal part is the dry aerial parts of portulacaceous plant Herba Portulacae.Acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.Toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis." Bencao Jingshu ": all Deficiency and coldness of spleen and stomach, intestinal is sliding is used as the person of letting out not; Decocting must not with Carapax Trionycis with entering in bait side.The ethanol immersion of Herba Portulacae has to escherichia coli, dysentery bacterium, Bacillus typhi etc. the inhibitory action shown, and has the laudatory title of " natural antibiotics "; Folium Ricini: containing Kaempferol-rutinoside, Isoquercitrin, globulariacitrin, nimbecetin, Quercetin, Radix Astragali glycoside, reynoutrin.Still containing ricidine., vitamin C 275mg%.Bitter in the mouth, pungent, property is put down, mild toxicity.Expelling wind and removing dampness, detumescence of drawing out pus by applying a plaster to the affected part.Main beriberi, rheumatic arthralgia, carbuncle pyogenic infections from tumour or sore, scabies pruritus, uterine prolapse, proctoptosis, chants phlegm dyspnea of coughing; Herba Patriniae: bitter, flat.Enter liver, stomach, large intestine channel.Heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Control acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies." property of medicine opinion ": control malicious wind insensitive impediment, main broken blood stasis for many years, can suppurate for water.And puerperal all diseases.Only stomachache remaining rash, excessive thirst." book on Chinese herbal medicine converge with speech ": prolonged illness insufficiency of stomach board is weak, the disease of not eating of having loose bowels, disease de-under all deficiency and coldness, saltyly avoids it; Folium sidae alnifoliae: taste is micro-sour and astringent, cool in nature, nontoxic.GUIXIN warp.Heat clearing away is drawn out pus by applying a plaster to the affected part, removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery, jaundice, laryngopharynx swelling and pain, carbuncle sore tumefacting virus, bee venom sting; Alpine yarrow: with all herbal medicine.Xia Qiu gathers, many using fresh herbs.Light, flat.Heat-clearing and toxic substances removing, removing blood stasis to reduce swelling, pain relieving.For venom, traumatic injury, postnatal blood stasis is suffered from abdominal pain; External is controlled furuncle and is swollen and ache; Caulis Viburni Dilatati: sour in the mouth, cold nature.Root: pungent, puckery, cool.Removing blood stasis to reduce swelling.For scrofula, traumatic injury.Branch, leaf: acid are cool.Heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome.For furuncle heating, summer-heat cold; Outer for allergic dermatitis.Dispelling wind detoxifies, and heat-clearing and toxic substances removing, invigorates blood circulation.Main anemopyretic cold, furuncle is generated heat, puerperal cold, injury and bone fracture.This product decoct has inhibitory action in various degree to staphylococcus aureus, anthrax bacillus, diphtheria corynebacterium, bacillus pyocyaneus, group B streptococcus, friend enterobacteria, Bacillus typhi and dysentery bacterium in vitro; Radix Cirsii Japonici: medicinal part is dry aerial parts or the root of plant.Sweet, bitter, cold.GUIXIN, Liver Channel.Cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrorrhagia, traumatic hemorrhage, carbuncle sore tumefacting virus; Periostracum Serpentis: for animal slough off under dry epidermis film.Salty in the mouth, sweet, property is put down.Return Liver Channel.Dispel the wind, arresting convulsion, nebula removing, the effect of removing toxic substances.For infantile convulsion, tic spasm, cataracta, sore throat, treats swollen, skin pruritus; Radix Ampelopsis: medicinal part is the dried root of vitaceae Radix Ampelopsis.Hardship, is slightly cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation.For carbuncle carbuncle on the back, furuncle, scrofula, burn and scald; Folium Capsici: bitter in the mouth, warm in nature.Detumescence washs network, killing parasites for relieving itching.Main edema, stubborn dermatitis, scabies, chilblain, carbuncle; Radix Marsdeniae Longipedis: be used as medicine with root or Herb.Sweet, micro-hardship, puckery, temperature.Poisonous.Promoting blood circulation and hemostasis, relieving cough and asthma.For traumatic injury, rheumatalgia, internal hemorrhage, bronchitis, asthma; Fracture is controlled in external, traumatic hemorrhage.Relaxing muscles and tendons and activating QI and blood in the collateral, invigorating deficiency and relieving dyspnea; Pheretima: salty, cold.Return liver, spleen, urinary bladder channel.Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.External is coated with the disease such as erysipelas, dermatitis rhus; Herba Chelidonii: cool in nature, bitter in the mouth; Slightly poisonous.Return lung, the heart, kidney channel." the conventional Chinese herbal medicine in the north ": have analgesia, cough-relieving, sterilization, diuresis, separate the merit of sore.Treating acute and chronic gastritis, gastric ulcer, stomachache, dysentery, cough, cirrhotic ascites." Shanxi Chinese medicinal herbal ": lower heart-fire, brings down a fever antipyretic, anti-inflammation and sterilization, antalgic and sedative; Rhizoma Polygonati Cirrhifolii: Gan Xin is flat.Nourishing lung-YIN, invigorating the spleen and benefiting QI, hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease cough, dizzy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, and spitted blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, and skin ulcer swells, scrofula; Fructus Cnidii: medicinal part is dry mature fruit.Acrid in the mouth, hardship, warm in nature.Return kidney channel.Dampness is dispeled the wind, killing parasites for relieving itching, warming the kidney to invigorate YANG.For pudendal pruritus leukorrhagia, eczema pruritus, arthralgia chiefly caused by damp pathogen lumbago, impotence due to deficiency of the kidney, cold womb is infertile; Radix embeliae laetae: acid, puckery, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.Main pharyngitis, gingiva bleeding gingival hemorrhage, dysentery, has loose bowels, furuncle ulcer, skin pruritus, swelling and pain of hemorrhoid, traumatic injury; The Fructus Kochiae: medicinal part is the dry mature fruit of plant.Acrid in the mouth, hardship, cold in nature.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus; Folium piperis betlis: leaf, containing volatile oil, includes chavicol 7.2-16.7%, chavicol 2.7-6.2%, allylpyrocatechol 0-9.6%, carvacrol 2.2-5.6%, eugenol 26.8-42.5%, cymol 1.2-2.5%, 1,8-cineole 2.4-4.8%, methyleugenol 4.2-15.8%, caryophyllene 3.0-9.8%, Cadinene 2.4-8.8%, and uncertain sesquiterpene 4.5-6,8% etc.Ye Zhongshang is containing multiple free ammonia tomb acid, ascorbic acid, malic acid, oxalic acid, glucose, fructose, maltose, glucuronic acid etc.Pungent, temperature.Dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching.Control cough due to wind and cold, stomachache, pathogenic wind-toxic beriberi, edema during pregnancy, mange, eczema, tinea pedis, scald; Folium Sansevieriae Trifasclatae: for Liliaceae Folium Sansevieriae Trifasclatae belongs to the leaf of Folium Sansevieriae Trifasclatae or Sansevieria laurentii." Luchuan book on Chinese herbal medicine ": cool in nature, sour in the mouth.Heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Main flu, cough due to lung-heat, sore swollen toxin, traumatic injury, venom, burn and scald." Guangxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation.Cure cold cough, bronchitis, traumatic injury, carbuncle pyogenic infections from tumour or sore, venom."; Radix Dipsaci: the dry root being Dipsacaceae plant Radix Dipsaci.It is warm in nature, bitter in the mouth, pungent, has effect of invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia, can be used for the disease for the treatment of soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Wherein prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down, and prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.It contains more vitamin E, therefore energy skin moistening, defying age; Flos Osmanthi Fragrantis: flower contains aromatic substance, as decanolactone, α-ionone, alpha, beta-lonone, trans-linalool oxide, cis-linalool oxide, linalool, aldehyde C-9 and β-phellandrene, nerol, Geraniol, dihydro-β-ionone.Flower CHENXIANG is assailed the nostrils, and Bracing is pungent, temperature.The broken knot of cold expelling, preventing phlegm from forming and stopping coughing.For toothache, cough with asthma abundant expectoration, amenorrhea is suffered from abdominal pain; Flos Jasmini Sambac: the Hua Jixiang of jasmine is famous scented tea raw material and important flavor of raw material.Flower acrid, sweet, warm.Regulate the flow of vital energy, dissipating depression of QI, wards off dirty, and in.For dysentery stomachache, conjunctival congestion is red and swollen, sore.Flos Jasmini Sambac can extract Flos Jasmini Sambac oil, and in oil, main component is benzyl alcohol and esters, jasmone, linalool, benzoic acid Lignum cinnamomi camphorae alcohol ester; Aloe: bitter, cold.Hydroxy kind contained by it, anthraquinone derivatives tools as many in organic active ingredients such as aloe-emodins kill, press down skin surface bacterial action, and complex polysaccharide and organic acid are natural moisturizing elements, can supplement the moisture lost in skin, repair Skin Cell.Be not taken by pregnant women, weakness of the spleen and stomach person is forbidden.There is bactericidal action, antiinflammatory action, moistening beautification function, under stomach invigorating, let out effect, the heart tonifying effect of invigorating blood circulation, immunity and regeneration, immunity and antitumor action, Detoxication, anti-aging effects, analgesia, sedation, anti-sunlight function; Radix Glycyrrhizae: the flat sweet in the mouth of property.Enter spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong; Lanoline: lanoline is the one secretion oils and fats be attached on Pilus Caprae seu Ovis, is soft paste that is faint yellow or brown color, has stickiness and satiny, smelly faint and special.Lanoline can allow skin smooth tender.Drying or rough skin because lacking natural moisture can be made to soften and be restored.Principal agent can be made to be absorbed by mucosa and skin rapidly, have adhesive force, stable in properties, and can absorb water, not easily become sour; Cera Flava: Cera Flava is the material of four pairs of wax gland secretions below worker bee abdominal part, and its main component has: acids, free fatty, free alkyl alcohol and carbohydrate.In addition, carotenoid, vitamin A, aromatic substance etc. are also had.In medical industry, Cera Flava can be used for the shell manufacturing dental casting wax, base plate wax, sticky wax, pill.Sweet, tepor.Return spleen, stomach, large intestine channel.Astringent therapy, sore, granulation promoting, pain relieving, conditioning.Outer for ulcer being unable to heal, ecthyma is rotten to the corn, wound, burn; The pathogeny of chilblain be due to skin endure cold after blood circulation poor, local cells hydrops, hydrops in cell cannot flow with blood circulation, in brief with regard to cold blood stasis, stagnation of QI and blood may bring about pain, thus occurred red and swollen, itch, the clinical manifestation such as pain, more red and swollenly more cause disturbance of blood circulation, generation vesicle time serious, wound surface are red and swollen, rotten to the corn.
Traditional Chinese medicine emulsifiable paste provided by the invention is for the pathogeny of chilblain, formula is drawn out pus by applying a plaster to the affected part with heat clearing away, removing blood stasis to reduce swelling, promoting blood circulation to remove obstruction in the collateral, Pesticidal and sterilizing, the necrotic tissue and promoting muscle growing that disappears is for the rule for the treatment of, selected medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, while effectively alleviating chilblain malaise symptoms fast, chilblain can be treated from root.Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis, Pesticidal and sterilizing in side, Folium Ricini expelling wind and removing dampness, detumescence of drawing out pus by applying a plaster to the affected part, Herba Patriniae heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs, Folium sidae alnifoliae heat clearing away is drawn out pus by applying a plaster to the affected part, removing toxic substances and promoting subsidence of swelling, is monarch drug altogether, for redness, the erosion of chilblain, heat clearing away is drawn out pus by applying a plaster to the affected part, removing toxic substances and promoting subsidence of swelling, alpine yarrow, Caulis Viburni Dilatati, Radix Cirsii Japonici, Periostracum Serpentis, Radix Ampelopsis, Folium Capsici, Radix Marsdeniae Longipedis, Pheretima is ministerial drug, wherein alpine yarrow heat-clearing and toxic substances removing, removing blood stasis to reduce swelling, pain relieving, Caulis Viburni Dilatati removing blood stasis to reduce swelling, Radix Cirsii Japonici cooling blood for hemostasis, removing blood stasis to reduce swelling, Periostracum Serpentis dispels the wind, arresting convulsion, nebula removing, the effect of removing toxic substances, Radix Ampelopsis heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation, network is washed in Folium Capsici detumescence, killing parasites for relieving itching, Radix Marsdeniae Longipedis promoting blood circulation and hemostasis, Pheretima heat clearing away dredging collateral, this eight tastes medicine with the use of, for the cold blood stasis that the blood circulation difference after enduring cold due to skin causes, removing blood stasis to reduce swelling, promoting blood circulation to remove obstruction in the collateral, general rule is not bitterly, Herba Chelidonii has the merit of analgesia cough-relieving, sterilization diuresis, solution sore, Rhizoma Polygonati Cirrhifolii subduing swelling and detoxicating, Fructus Cnidii dampness is dispeled the wind, killing parasites for relieving itching, Radix embeliae laetae heat-clearing and toxic substances removing, dissipating blood stasis stop blooding, Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching , Folium piperis betlis dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching, this Six-element medicine share the effect with subduing swelling and detoxicating, Pesticidal and sterilizing, dispelling wind for relieving itching, effect that the vesicle caused for chilblain, wound surface are red and swollen, erosion has Pesticidal and sterilizing, dispelling wind for relieving itching, Folium Sansevieriae Trifasclatae heat-clearing and toxic substances removing, promoting blood circulation and detumescence, Radix Dipsaci contains more vitamin E, therefore energy skin moistening, defying age, Flos Osmanthi Fragrantis, Flos Jasmini Sambac are containing multiple aromatic substance, the fragrance of flowers is strong, Aloe has the effect of sterilization antiinflammatory, moistening beauty treatment, and lanoline can make principal agent be absorbed by mucosa and skin rapidly, has adhesive force, stable in properties, Cera Flava astringent therapy sore, granulation promoting pain relieving, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, also can coordinating the actions of various ingredients in a prescription, for chilblain produce the astringent therapy sore such as vesicle, erosion, disappear necrotic tissue and promoting muscle growing, altogether for making medicine.In side, all medicines meet monarch principle, reasonable compatibility by weight ratio, play that heat clearing away is drawn out pus by applying a plaster to the affected part altogether, removing blood stasis to reduce swelling, promoting blood circulation to remove obstruction in the collateral, Pesticidal and sterilizing, the necrotic tissue and promoting muscle growing that disappears merit, the blood circulation of skin of making to endure cold is normal, eliminate local cells hydrops, namely eliminate cold blood stasis, simultaneously for red and swollen, itch, bitterly, the clinical manifestation such as rotten to the corn has Pesticidal and sterilizing, the effect of the necrotic tissue and promoting muscle growing that disappears.Lanoline can make principal agent be absorbed by mucosa and skin rapidly simultaneously, strong adhesion, stable in properties, and can absorb water, not easily become sour, because toughness is large, be affixed on skin and have sense of compacting, therefore share with Cera Flava, water absorption and the penetrance of Cera Flava can be increased, more give full play to drug effect, improve curative effect, persistent, and there is the effect of nourishing skin, and all medicines are coordinated mutually, little on body impact, application safety.
In preparation method of the present invention, employing ethanol stirs the effective ingredient in ultrasonic lixiviate part Chinese medicine, Chinese medicine is subject to hyperacoustic mechanical shearing effect in leaching process, cell is more easily broken, effective ingredient wherein is more easily precipitated, filter filtering residue continuation with soak by water once, the effective ingredient in Chinese medicine can be extracted to a greater extent, makes tincture of the present invention have higher curative effect; Plurality of Chinese adopted the fresh Chinese medicine do not dried to be ground to slurry to be used as medicine, effective ingredient wherein can not run off, better effects if, and Flos Osmanthi Fragrantis, the fragrance of flowers is strong for Flos Jasmini Sambac, makes this disinfecting paste have colored fragrance, when being coated in affected part, dense taste of Chinese medicine can not be had, make people acceptant.
The invention has the beneficial effects as follows:
(1) traditional Chinese medicine emulsifiable paste of the present invention is drawn out pus by applying a plaster to the affected part with heat clearing away on formula, removing blood stasis to reduce swelling, promoting blood circulation to remove obstruction in the collateral, Pesticidal and sterilizing, the necrotic tissue and promoting muscle growing that disappears is for the rule for the treatment of, selected medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, containing plurality of Chinese composition, can chilblain be treated from root, comprehensively killing is antipruritic while fast effectively alleviating chilblain malaise symptoms, scattered silt pain relieving, also there is removing the necrotic tissue and promoting granulation, nourish effect of skin, to skin nonirritant;
(2) traditional Chinese medicine emulsifiable paste of the present invention in the preparation plurality of Chinese adopt the fresh Chinese medicine do not dried to be ground to slurry and to be used as medicine, it contains abundant vitamin C, vitamin E, aromatic alcohol, aldehyde, fatty acid, phenol and containing the oil of essence and fat etc., can play skin and effectively nourish moisturizing, antidotal effect, effective ingredient wherein can not run off, better effects if, and Flos Osmanthi Fragrantis, the fragrance of flowers is strong for Flos Jasmini Sambac, this disinfecting paste is made to have colored fragrance, when being coated in affected part, dense taste of Chinese medicine can not be had, make people acceptant, gentleness does not stimulate, without sharp aroma,
(3) soft and Operand in traditional Chinese medicine emulsifiable paste of the present invention, can effectively avoid ethanol to the injury of skin, wherein with lanoline and Cera Flava for carrier, good stability, after being coated in affected part, principal agent can be made to be absorbed by mucosa and skin rapidly, strong adhesion, stable in properties, and can absorb water, not easily become sour, share with Cera Flava, water absorption and the penetrance of Cera Flava can be increased, its drug effect can be played more fully, improve curative effect, persistent, and there is the effect of nourishing skin, and all medicines are coordinated mutually, little on body impact, application safety.
Detailed description of the invention
Below in conjunction with embodiments of the invention, technical scheme of the present invention is clearly and completely described.
Embodiment 1
Treat a traditional Chinese medicine emulsifiable paste for chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 20 parts, Folium Ricini 20 parts, Herba Patriniae 15 parts, Folium sidae alnifoliae 10 parts, alpine yarrow 8 parts of, Caulis Viburni Dilatati 8 parts, Radix Cirsii Japonici 6 parts, Periostracum Serpentis 6 parts, Radix Ampelopsis 10 parts, Folium Capsici 10 parts, Radix Marsdeniae Longipedis 8 parts, Pheretima 6 parts, Herba Chelidonii 6 parts, Rhizoma Polygonati Cirrhifolii 6 parts, Fructus Cnidii 8 parts, Radix embeliae laetae 6 parts, the Fructus Kochiae 4 Fen, Folium piperis betlis 8 parts, Folium Sansevieriae Trifasclatae 6 parts, Radix Dipsaci 6 parts, Flos Osmanthi Fragrantis 8 parts, Flos Jasmini Sambac 8 parts, Aloe 8 parts, 10 parts, Radix Glycyrrhizae, lanoline 50 parts, 60 parts, Cera Flava.
The preparation method of the traditional Chinese medicine emulsifiable paste of described treatment chilblain, comprises the following steps:
(1) by the Herba Portulacae of said ratio, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 3 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 3 times of soak by water 1h, filter, filtrate is condensed into the lixiviate cream II of when relative density is 50 DEG C 1.20;
(3) after the Periostracum Serpentis wine of said ratio being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline of said ratio, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
Using method: be coated with by traditional Chinese herb medicine of the present invention and put on the skin in affected part, being coated with and putting thickness on the skin is 0.5mm, every day 2 times, sooner or later respectively once.
Embodiment 2
A kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 40 parts, Folium Ricini 40 parts, Herba Patriniae 35 parts, Folium sidae alnifoliae 30 parts, alpine yarrow 20 parts, Caulis Viburni Dilatati 20 parts, Radix Cirsii Japonici 18 parts, Periostracum Serpentis 12 parts, Radix Ampelopsis 20 parts, Folium Capsici 20 parts, Radix Marsdeniae Longipedis 14 parts, Pheretima 12 parts, Herba Chelidonii 10 parts, Rhizoma Polygonati Cirrhifolii 12 parts, Fructus Cnidii 16 parts, Radix embeliae laetae 10 parts, the Fructus Kochiae 10 parts, Folium piperis betlis 12 parts, Folium Sansevieriae Trifasclatae 12 parts, Radix Dipsaci 14 parts, Flos Osmanthi Fragrantis 18 parts, Flos Jasmini Sambac 18 parts, Aloe 16 parts, 20 parts, Radix Glycyrrhizae, lanoline 70 parts, 80 parts, Cera Flava.
The preparation method of the traditional Chinese medicine emulsifiable paste of described treatment chilblain, comprises the following steps:
(1) by the Herba Portulacae of said ratio, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 5 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 5 times of soak by water 2h, filter, filtrate is condensed into the lixiviate cream II of when relative density is 50 DEG C 1.25;
(3) after the Periostracum Serpentis wine of said ratio being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline of said ratio, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
Using method: be coated with by traditional Chinese herb medicine of the present invention and put on the skin in affected part, being coated with and putting thickness on the skin is 0.5mm, every day 2 times, sooner or later respectively once.
Embodiment 3
A kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 25 parts, Folium Ricini 25 parts, Herba Patriniae 20 parts, Folium sidae alnifoliae 15 parts, alpine yarrow 10 parts, Caulis Viburni Dilatati 12 parts, Radix Cirsii Japonici 10 parts, Periostracum Serpentis 8 parts, Radix Ampelopsis 12 parts, Folium Capsici 12 parts, Radix Marsdeniae Longipedis 10 parts, Pheretima 8 parts, Herba Chelidonii 7 parts, Rhizoma Polygonati Cirrhifolii 8 parts, Fructus Cnidii 10 parts, Radix embeliae laetae 7 parts, the Fructus Kochiae 6 parts, Folium piperis betlis 9 parts, Folium Sansevieriae Trifasclatae 8 parts, Radix Dipsaci 8 parts, Flos Osmanthi Fragrantis 10 parts, Flos Jasmini Sambac 10 parts, Aloe 10 parts, 12 parts, Radix Glycyrrhizae, lanoline 55 parts, 65 parts, Cera Flava.
The preparation method of the traditional Chinese medicine emulsifiable paste of described treatment chilblain, comprises the following steps:
(1) by the Herba Portulacae of said ratio, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 3 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 4 times of soak by water 1.5h, filter, filtrate is condensed into the lixiviate cream II of when relative density is 50 DEG C 1.22;
(3) after the Periostracum Serpentis wine of said ratio being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline of said ratio, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
Using method: be coated with by traditional Chinese herb medicine of the present invention and put on the skin in affected part, being coated with and putting thickness on the skin is 0.5mm, every day 2 times, sooner or later respectively once.
Embodiment 4
A kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 35 parts, Folium Ricini 35 parts, Herba Patriniae 30 parts, Folium sidae alnifoliae 25 parts, alpine yarrow 18 parts, Caulis Viburni Dilatati 16 parts, Radix Cirsii Japonici 14 parts, Periostracum Serpentis 10 parts, Radix Ampelopsis 18 parts, Folium Capsici 18 parts, Radix Marsdeniae Longipedis 12 parts, Pheretima 10 parts, Herba Chelidonii 9 parts, Rhizoma Polygonati Cirrhifolii 10 parts, Fructus Cnidii 14 parts, Radix embeliae laetae 9 parts, the Fructus Kochiae 8 parts, Folium piperis betlis 11 parts, Folium Sansevieriae Trifasclatae 10 parts, Radix Dipsaci 12 parts, Flos Osmanthi Fragrantis 16 parts, Flos Jasmini Sambac 16 parts, Aloe 14 parts, 18 parts, Radix Glycyrrhizae, lanoline 65 parts, 75 parts, Cera Flava.
The preparation method of the traditional Chinese medicine emulsifiable paste of described treatment chilblain, comprises the following steps:
(1) by the Herba Portulacae of said ratio, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 4 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 5 times of soak by water 2h, filter, filtrate is condensed into the lixiviate cream II of when relative density is 50 DEG C 1.23;
(3) after the Periostracum Serpentis wine of said ratio being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline of said ratio, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
Using method: be coated with by traditional Chinese herb medicine of the present invention and put on the skin in affected part, being coated with and putting thickness on the skin is 0.5mm, every day 2 times, sooner or later respectively once.
Embodiment 5
A kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 30 parts, Folium Ricini 30 parts, Herba Patriniae 25 parts, Folium sidae alnifoliae 20 parts, alpine yarrow 14 parts, Caulis Viburni Dilatati 14 parts, Radix Cirsii Japonici 12 parts, Periostracum Serpentis 9 parts, Radix Ampelopsis 15 parts, Folium Capsici 15 parts, Radix Marsdeniae Longipedis 11 parts, Pheretima 9 parts, Herba Chelidonii 8 parts, Rhizoma Polygonati Cirrhifolii 9 parts, Fructus Cnidii 12 parts, Radix embeliae laetae 8 parts, the Fructus Kochiae 7 parts, Folium piperis betlis 10 parts, Folium Sansevieriae Trifasclatae 9 parts, Radix Dipsaci 10 parts, Flos Osmanthi Fragrantis 13 parts, Flos Jasmini Sambac 13 parts, Aloe 12 parts, 15 parts, Radix Glycyrrhizae, lanoline 60 parts, 70 parts, Cera Flava.
The preparation method of the traditional Chinese medicine emulsifiable paste of described treatment chilblain, comprises the following steps:
(1) by the Herba Portulacae of said ratio, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 4 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 4 times of soak by water 1.5h, filter, filtrate is condensed into the lixiviate cream II of when relative density is 50 DEG C 1.22;
(3) after the Periostracum Serpentis wine of said ratio being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline of said ratio, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
Using method: be coated with by traditional Chinese herb medicine of the present invention and put on the skin in affected part, being coated with and putting thickness on the skin is 0.5mm, every day 2 times, sooner or later respectively once.
Embodiment 6
Acute toxicity testing:
Healthy adult SD rat 40, male and female half and half, body weight is suitable, all between 220 ± 10g, test and cut off by rat back spinal column diamond wool for first 24 hours, unhairing scope is about 2cm*2cm, during formal test, be coated on skin of unhairing by traditional Chinese medicine emulsifiable paste of the present invention, be then covered with oilpaper blend compounds cloth and fix, it is 5000mg/kg body weight that a percutaneous smears dosage.Observe 14 days, test rat body situation, diet, drinking-water, body weight increase all normal, do not occur obvious intoxicating phenomenon and the phenomena of mortality, and place's post mortem Non Apparent Abnormality, judges that this Chinese medicine composition is to the nontoxic level in the true border of rat acute percutaneous toxicity.
Embodiment 7
Clinical experimental study:
(1) clinical data:
For investigating clinical efficacy and the safety of traditional Chinese medicine emulsifiable paste of the present invention further, choosing the patient that 166 examples suffer from chilblain and clinical observation being carried out to the curative effect of traditional Chinese medicine emulsifiable paste of the present invention, wherein men and women half and half.
(2) diagnosis basis
By disease of tcm Standardization of diagnosis and curative effect: chilblain is because being subject to attacked by the cold and evil, stagnation of QI-blood, the purplish red numb twinge of skin, or local skin is downright bad, notably can cause whole body numb with cold.Be equivalent to cold injury.There is the medical history of stay longer under low temperature environment.
General chilblain: have serious freezing history.From the beginning of time shiver with cold, body temperature reduces gradually, occurs dizzy sleepy, myasthenia of limbs later, insensitive.And then obnubilation, breathing shoals, and pulse condition is thin and delicate.
Locality chilblain: be mainly in tip position and the exposure portion such as hands, foot, nose, auricle and buccal.
Mild case: from the beginning of enduring cold area skin first in pale, continue then red and swollen, or have scleroma, speckle, edge is red, and central authorities are livid purple, cold type of pain, or sense is numb, conscious scorching hot during warm heat, pruritus, distending pain.
Heavily demonstrate,prove: have the vesicle or lump that differ in size, skin is greyish white or dark red, or turns purple, sharp ache, or local anesthesia.Occur rotten to the corn or ulcer after vesicle is broken, very then muscle muscles and bones is downright bad.
(3) Therapeutic Method
Traditional Chinese herb medicine of the present invention being coated with puts on the skin in affected part, and being coated with and putting thickness on the skin is 0.5mm, and severe one can lagging simultaneously, every day 2 times, sooner or later each once, record result after 20 days.
(4) efficacy evaluation
Cure: General Symptoms disappears, lump dissipates, wound healing, and skin restores to the original state.
Take a turn for the better: General Symptoms disappears substantially, and do not heal completely in skin ulcer face, skin is necessarily recovered.
Do not heal: whole body and local circumstance are without improvement.
(5) therapeutic outcome
As can be seen from above-mentioned therapeutic outcome, the curative effect of traditional Chinese medicine emulsifiable paste of the present invention to chilblain is fabulous, and cure rate is 87.35%, and total effective rate reaches 99.4%, be the potion good medicine for the treatment of chilblain, and other symptoms does not appear in all patients during clinical trial.
(5) model case
Case 1: Tang, female, 22 years old, university student, every winter hands, can chilblain be there is in auricle place, have the vesicle and lump that differ in size, skin is kermesinus, and gargalesthesia is obvious.The traditional Chinese medicine emulsifiable paste of external application treatment chilblain of the present invention is treated, and after 10 days, symptom obviously alleviates, and continue use after 10 days, symptom all disappears, and skin color is normal, without cicatrix.
Case 2: Xiao, female, 52 years old, patient suffered from chilblain existing 5 years, affected skin has the edematous erythema of congestive dark violet redness protuberance, and indefinite border, edge is cerise, and the vesicle differed in size time serious, even occurs erosion.Use the traditional Chinese medicine emulsifiable paste for the treatment of chilblain of the present invention to treat, after 10 days, symptom obviously alleviates, and continue use after 10 days, symptom all disappears, and skin color is normal, without cicatrix, follows up a case by regular visits to 2 years without recurrence.
The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (4)

1. treat the traditional Chinese medicine emulsifiable paste of chilblain for one kind, it is characterized in that, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 20-40 part, Folium Ricini 20-40 part, Herba Patriniae 15-35 part, Folium sidae alnifoliae 10-30 part, alpine yarrow 8-20 part, Caulis Viburni Dilatati 8-20 part, Radix Cirsii Japonici 6-18 part, Periostracum Serpentis 6-12 part, Radix Ampelopsis 10-20 part, Folium Capsici 10-20 part, Radix Marsdeniae Longipedis 8-14 part, Pheretima 6-12 part, Herba Chelidonii 6-10 part, Rhizoma Polygonati Cirrhifolii 6-12 part, Fructus Cnidii 8-16 part, Radix embeliae laetae 6-10 part, Fructus Kochiae 4-10 part, Folium piperis betlis 8-12 part, Folium Sansevieriae Trifasclatae 6-12 part, Radix Dipsaci 6-14 part, Flos Osmanthi Fragrantis 8-18 part, Flos Jasmini Sambac 8-18 part, Aloe 8-16 part, Radix Glycyrrhizae 10-20 part, lanoline 50-70 part, Cera Flava 60-80 part.
2. a kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain as claimed in claim 1, it is characterized in that, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 25-35 part, Folium Ricini 25-35 part, Herba Patriniae 20-30 part, Folium sidae alnifoliae 15-25 part, alpine yarrow 10-18 part, Caulis Viburni Dilatati 12-16 part, Radix Cirsii Japonici 10-14 part, Periostracum Serpentis 8-10 part, Radix Ampelopsis 12-18 part, Folium Capsici 12-18 part, Radix Marsdeniae Longipedis 10-12 part, Pheretima 8-10 part, Herba Chelidonii 7-9 part, Rhizoma Polygonati Cirrhifolii 8-10 part, Fructus Cnidii 10-14 part, Radix embeliae laetae 7-9 part, Fructus Kochiae 6-8 part, Folium piperis betlis 9-11 part, Folium Sansevieriae Trifasclatae 8-10 part, Radix Dipsaci 8-12 part, Flos Osmanthi Fragrantis 10-16 part, Flos Jasmini Sambac 10-16 part, Aloe 10-14 part, Radix Glycyrrhizae 12-18 part, lanoline 55-65 part, Cera Flava 65-75 part.
3. a kind of traditional Chinese medicine emulsifiable paste for the treatment of chilblain as claimed in claim 1, it is characterized in that, raw material composition and the mass fraction thereof of making described traditional Chinese medicine emulsifiable paste effective ingredient are: Herba Portulacae 30 parts, Folium Ricini 30 parts, Herba Patriniae 25 parts, Folium sidae alnifoliae 20 parts, alpine yarrow 14 parts, Caulis Viburni Dilatati 14 parts, Radix Cirsii Japonici 12 parts, Periostracum Serpentis 9 parts, Radix Ampelopsis 15 parts, Folium Capsici 15 parts, Radix Marsdeniae Longipedis 11 parts, Pheretima 9 parts, Herba Chelidonii 8 parts, Rhizoma Polygonati Cirrhifolii 9 parts, Fructus Cnidii 12 parts, Radix embeliae laetae 8 parts, the Fructus Kochiae 7 parts, Folium piperis betlis 10 parts, Folium Sansevieriae Trifasclatae 9 parts, Radix Dipsaci 10 parts, Flos Osmanthi Fragrantis 13 parts, Flos Jasmini Sambac 13 parts, Aloe 12 parts, 15 parts, Radix Glycyrrhizae, lanoline 60 parts, 70 parts, Cera Flava.
4. a kind of preparation method for the treatment of the traditional Chinese medicine emulsifiable paste of chilblain as described in claim 1-3 any one, is characterized in that, comprise the following steps:
(1) by Herba Portulacae, Folium Ricini, Radix Cirsii Japonici, Radix Ampelopsis, Pheretima, Herba Chelidonii, Rhizoma Polygonati Cirrhifolii, the Fructus Kochiae, Folium piperis betlis, Folium Sansevieriae Trifasclatae, Radix Dipsaci, Radix Glycyrrhizae grinds, mixed-powder is mixed to get after crossing 80 mesh sieves, then the ethanol that mass fraction is 75% is added, the amount adding ethanol was as the criterion there not to be mixed-powder, load hermetic container soak and stir 3-5 days, stir speed (S.S.) is 100r/min, add ultrasonic in immersion process, every the ultrasonic 10min of 1h, ultrasonic power 250w, supersonic frequency 50KHz, then its medicinal liquid is filtered, collect filtering residue, reclaim the ethanol in filtrate, obtain lixiviate cream I,
(2) step (1) gained filtering residue is added 3-5 times of soak by water 1-2h, filter, filtrate is condensed into the lixiviate cream II of 1.20-1.25 when relative density is 50 DEG C;
(3) after Periostracum Serpentis wine being processed method fried dry, be mixed in air-stream type ultrafine pulverizer pulverize with Fructus Cnidii, Radix Marsdeniae Longipedis, the operating pressure of described air-stream type ultrafine pulverizer is 0.8MPa, systematic air flow is 3m 3/ min, rotating speed is 3000r/min, and charging rate is 10kg/h, and crosses 325 mesh sieves, obtains Chinese medicine ultra-fine powder;
(4) after fresh, the Herba Patriniae without damaging, Folium sidae alnifoliae, alpine yarrow, Caulis Viburni Dilatati, Folium Capsici, Radix embeliae laetae, Flos Osmanthi Fragrantis, Flos Jasmini Sambac, Aloe being cleaned, common feeding fiberizer carries out defibrination, rotating speed is 3000r/min, the defibrination time is 60min, 100 eye mesh screens crossed by gained mixing juice, collect filtrate;
(5) lanoline, Cera Flava are heated to 50-55 DEG C, add the obtained lixiviate cream II of the obtained lixiviate cream I of step (1), step (2) under stirring condition successively, filtrate prepared by Chinese medicine ultra-fine powder prepared by step (3), step (4), stir and be cooled to room temperature, package spare, obtain described traditional Chinese medicine emulsifiable paste.
CN201510275515.7A 2015-05-26 2015-05-26 Traditional Chinese medicine emulsifiable paste for treating chilblain and preparation method of traditional Chinese medicine emulsifiable paste Pending CN104815169A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1939516A (en) * 2006-09-26 2007-04-04 胡景林 Chinese medicine for treating burn, scald and frostbite
CN102657752A (en) * 2012-05-16 2012-09-12 田防震 Medicament for treating chilblain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1939516A (en) * 2006-09-26 2007-04-04 胡景林 Chinese medicine for treating burn, scald and frostbite
CN102657752A (en) * 2012-05-16 2012-09-12 田防震 Medicament for treating chilblain

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* Cited by examiner, † Cited by third party
Title
焦继泰: "马齿览煎液治疗冻疮", 《四川中医》 *

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Application publication date: 20150805