CN104814820A - Vascular support for preventing vascular restenosis - Google Patents

Vascular support for preventing vascular restenosis Download PDF

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Publication number
CN104814820A
CN104814820A CN 201510132130 CN201510132130A CN104814820A CN 104814820 A CN104814820 A CN 104814820A CN 201510132130 CN201510132130 CN 201510132130 CN 201510132130 A CN201510132130 A CN 201510132130A CN 104814820 A CN104814820 A CN 104814820A
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stent
support member
restenosis
vascular
blood vessel
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CN 201510132130
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Chinese (zh)
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罗宇新
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苏州固基电子科技有限公司
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Abstract

The invention provides a vascular support for preventing vascular restenosis, and the support is tubular. The support comprises a plurality of supporting units which are uniformly distributed along the axial direction, and connecting parts which are used for enabling the plurality of supporting units to be connected together. Each supporting unit comprises a flexible supporting part and a rigid supporting part which is connected in the flexible supporting part. The support not only can prevent the expansion of the support from damaging a vascular wall, but also does not affect the mechanical properties.

Description

一种防止血管再狭窄的血管支架 A method of preventing restenosis of a blood vessel stent

技术领域 FIELD

[0001] 本发明涉及一种防止血管再狭窄的血管支架,属于医疗器械技术领域。 [0001] The present invention relates to an intravascular stent to prevent restenosis of a blood vessel, a medical instrument technical field.

背景技术 Background technique

[0002] 1977年世界上第一例经皮冠状动脉介入手术(PCI)在瑞士完成,这例手术是用球囊对患者的左前降支狭窄处进行扩张,并取得了成功。 [0002] 1977 the world's first surgical percutaneous coronary intervention (PCI) done in Switzerland, which is a balloon surgeries on patients with left anterior descending artery stenosis to expand, and has been successful. 但是球囊扩张后血管的再狭窄率很高,超过50%。 But after balloon dilation of a blood vessel restenosis rate is very high, more than 50%. 主要原因是,在血管被扩张并撤掉外力后,血管会弹性回缩。 The main reason is that after the expansion of blood vessels are removed and external forces, blood vessels elastic recoil. 在上世纪80年代,发明了广泛运用于冠状动脉的血管支架,主要有不锈钢、钴铬合金或者镍钛合金制成的金属血管支架,这些支架植入体内后,可以对血管提供一个持久的机械支撑,避免了血管的弹性回缩,降低了病变血管的再狭窄率。 In the 1980s, the invention is widely used in coronary vascular stents, mainly stainless steel, cobalt-chromium alloy, metallic vascular stents or Nitinol, which after stent implantation in vivo, can provide a durable mechanical vascular support, to avoid the elastic recoil of the vessel, reducing the rate of restenosis of the diseased vessel. 但是因为支架的永久植入,支架作为异物会导致内膜过度增生,血管的再狭窄比率也挺高。 However, since the stent permanently implanted stent as a foreign matter will lead to intimal hyperplasia, vascular restenosis rate pricey. 2003年以来,药物支架的应用使血管的再狭窄率降到10%左右。 Since 2003, the use of the stent restenosis rate dropped to about 10% of the blood vessels. 但是药物支架仍然永久存在于体内,作为异物的支架与血管组织之间在力学性质上存在很大差异,会引起血管的慢性损伤,后期会造成血管中层萎缩、内膜增生,最终还会导致血管的再狭窄,从而限制了血管再狭窄率的进一步降低。 But the stent remains permanently present in the body, as a chronic injury there is a big difference in mechanical properties between the stent and vascular tissue foreign body, can cause blood vessels, can cause blood vessel late middle atrophy, intimal hyperplasia, will eventually cause blood vessels restenosis, thereby restricting further reduce the restenosis rate. 对于儿童患者,植入固定尺寸的血管支架会阻碍血管的逐渐增大,不能适应其生长发育的需要。 For pediatric patients, the stent implanted in a fixed size will hinder gradually increasing blood vessels, can not meet the needs of its growth and development.

[0003] 针对血管狭窄的上述两种介入治疗技术都有缺点:采用球囊扩张血管,虽然短期效果较好,但是因为血管的弹性回缩,后期的再狭窄率非常高;在血管内植入金属支架,包括裸支架和药物支架,可以将狭窄血管扩张开,并提供一个持久的机械支撑,但是金属支架扩张过程中会造成血管内膜损伤,诱发血管内膜增生导致再狭窄。 [0003] interventional therapy for both vascular stenosis have disadvantages: the use of balloon dilation of blood vessels, although short-term effect is good, but because of elastic recoil of the vessel, late restenosis rate is very high; implanted in the vessel metal stent, including stents and a bare stent, the expansion of the stenosis can be opened and provide a permanent mechanical support, but the metal stent expansion process will cause intimal injury induced intimal hyperplasia leads to restenosis. 金属支架还存在血栓形成、出凝血并发症、屈曲性不匹配、金属物永久存留于体内会增加远期再狭窄发生率等缺陷。 There is also a metal stent thrombosis, coagulation complications, buckling does not match, the metal was permanent retention in the body will increase the occurrence of defects in the restenosis rate.

[0004]因此,支架植入术的成败和支架本身所具有的力学性能息息相关。 [0004] Thus, the success of stenting and stent itself has mechanical properties are closely related. 支架在膨胀时其轴向方向的缩短会导致支架在血管壁的两端造成损伤,从而进一步诱发血管病变部位再狭窄的发生。 Shortening the stent upon expansion thereof in the axial direction will cause damage to both ends of the stent in the vessel wall, thereby further induce vascular lesion restenosis. 因此轴向缩短性是血管支架很重要的一个力学性能,常用轴向缩短率来表示该指标的优良;轴向缩短率反映了支架膨胀前后长度的变化,它关系到支架长度的选用及定位的精确度。 Thus it is important to axial shortening of the mechanical properties of a vascular stent, the axial shortening used to represent the fine index; axial shortening rate reflects the change in length before and after expansion of the stent, it relates to the selection and positioning of the stent length Accuracy. 因此,支架的轴向缩短性能对支架术的成功起着至关重要的作用。 Thus, the axial shortening of the stent performance to the success of stenting plays a vital role. 但是现有的支架结构在支架完全扩张后都很难避免其在轴向发生缩短。 However, the conventional stent structure in fully expanded after the stent is very difficult to avoid the occurrence shortened in the axial direction.

发明内容 SUMMARY

[0005] 本发明为了解决现有技术中存在的上述缺陷和不足,提供了一种防止血管再狭窄的血管支架,既可以防止支架膨胀后对血管壁造成损伤,又不影响支架本身的力学性能。 [0005] In order to solve the above prior art drawbacks and deficiencies exist, there is provided a method of preventing restenosis of vascular stents, both to prevent damage to a vessel wall after expansion of the stent, the stent itself does not affect the mechanical properties of .

[0006] 为解决上述技术问题,本发明提供一种防止血管再狭窄的血管支架,所述血管支架为管状,包括沿轴向均匀分布的若干个支撑单元、将若干个所述支撑单元连接一起的连接件,所述支撑单元包括柔性支撑部件以及内接在所述柔性支撑部件内的刚性支撑部件。 [0006] To solve the above problems, the present invention provides a method of preventing restenosis of vascular stents, vascular stent is a tubular, comprising a number of support units uniformly distributed along the axial direction to connect together a plurality of the support unit connecting member, said support means comprising a rigid support member and an inner member connected to the flexible support within the flexible support member.

[0007] 优选地,所述柔性支撑部件为椭圆形,所述刚性支撑部件为菱形。 [0007] Preferably, the flexible support member is elliptical, the rigid support member is a diamond.

[0008] 优选地,:所述柔性支撑部件的长径与短径之比为3:2。 [0008] Preferably: said flexible support member is longer than the minor axis diameter of 3: 2.

[0009] 优选地,所述柔性支撑部件的材质为镁合金。 [0009] Preferably, the flexible support member is made of a magnesium alloy.

[0010] 优选地,所述刚性支撑部件的材质为医用不锈钢或钴铬合金。 [0010] Preferably, the rigid support member is made of medical stainless steel or cobalt-chromium alloy.

[0011] 优选地,所述连接件为直线连接杆。 [0011] Preferably, said connecting rod connecting member linearly.

[0012] 优选地,所述血管支架的长度为2-30cm。 [0012] Preferably, the stent length is 2-30cm.

[0013] 本发明所达到的有益技术效果: [0013] The present invention is achieved by the beneficial technical effects:

[0014] 本发明的支撑单元由柔性支撑部件和刚性支撑部件组成,且刚性支撑部件内接在柔性支撑部件内,在使用过程中,只有柔性支撑部件接触血管壁,不会对血管壁造成损伤,而同时,刚性支撑部件用来提供力学支撑,防止血管的再狭窄,有效降低了血管的再狭窄率;为了更好的保证柔性支撑部件对血管壁不造成损伤,将柔性支撑部件设计成椭圆形,且采用镁合金材质。 [0014] The support unit according to the present invention consists of a flexible support member and a rigid support components, and the rigid support member connected to the flexible support member, during use, only the flexible support member contacts the vessel wall, does not damage the vessel wall while, the rigid support member for providing mechanical support to prevent vascular restenosis, effectively reducing the rate of restenosis of blood vessels; in order to better ensure the flexible support member without causing damage to the vessel wall, the design of the flexible support member into an elliptical shaped, and the magnesium alloy material. 为了更好的保证刚性支撑部件的力学性能,将刚性支撑部件设计成菱形,且材质采用医用不锈钢或钴铬合金;支撑单元之间采用直线连接杆,使得血管支架在扩张后既能保持较高的径向支撑力,又具有轴向零缩短,有利于提高血管支架植入后的定位精度以及更进一步减少支架注入对血管壁的损失率。 In order to better ensure the mechanical properties of the rigid support member, the rigid support member designed as diamond, and the material used for medical stainless steel or cobalt-chromium alloy; straight-line connection between the lever support unit, such that the blood vessel stent after expansion keeps productivity high radial supporting force, and having a shorter axial zero, help to improve the positioning accuracy of the vascular stent and stent implantation to further reduce the loss of the vessel wall.

附图说明 BRIEF DESCRIPTION

[0015] 图1本发明结构展开示意图。 [0015] FIG invention is developed perspective view showing a structure.

具体实施方式 detailed description

[0016] 为了审查员能更好的了解本发明的技术特征、技术内容及其达到的技术效果,现将本发明的附图结合实施例进行更详细的说明。 [0016] For a better understanding of the examiner features of the invention, the technical content and to achieve the technical effect of the present invention in conjunction with the accompanying drawings will now be illustrated in more detail in the embodiments described. 然而,所示附图,只是为了更好的说明本发明的技术方案,并不是本发明的真实比例和最佳配置,所以,请审查员不要就附图的比例和配置,限制本发明的权利要求保护范围。 However, as shown in the drawings, just to better illustrate the technical solutions of the present invention and are not true to scale and the best configuration of the invention, therefore, not to make the drawings examiner proportions and configuration, to limit the claimed invention the claimed range.

[0017] 下面结合附图和实施例对本发明专利进一步说明。 Figures and examples further illustrate the present invention of the patent [0017] The following binding.

[0018] 如图1所示,本发明提供一种防止血管再狭窄的血管支架,所述血管支架为管状,包括沿轴向均匀分布的若干个支撑单元1、将若干个所述支撑单元I连接一起的连接件2,所述支撑单元I包括柔性支撑部件11以及内接在所述柔性支撑部件11内的刚性支撑部件 [0018] As shown in FIG. 1, the present invention provides a method of preventing restenosis of vascular stents, vascular stent is a tubular, comprising a number of support units 1 uniformly distributed in the axial direction, the plurality of the support unit I connection member 2 together, the support unit I comprises a flexible support member and a rigid support member 11 inscribed within the flexible member 11 of the support

12ο 12ο

[0019] 本发明的支撑单元I由柔性支撑部件11和刚性支撑部件12组成,且刚性支撑部件12内接在柔性支撑部件11内,植入后,只有柔性支撑部件11接触血管壁,不会对血管壁造成损伤,而同时,刚性支撑部件12用来提供力学支撑,防止血管的再狭窄,有效降低了血管的再狭窄率;为了更好的保证柔性支撑部件11对血管壁不造成损伤,将柔性支撑部件11设计成椭圆形,且采用镁合金材质。 [0019] The support unit I of the invention by a flexible supporting member 11 and the rigid support member 12 composed of, and within the support 12 connected to the flexible member 11 in the rigid support member, after implantation, only the flexible support member 11 contact with the vessel wall, not damage to the vessel wall, while the rigid support member 12 to provide mechanical support to prevent vascular restenosis, effectively reducing the rate of restenosis of blood vessels; 11 pairs in order to better ensure that the vessel wall without causing damage to the flexible support member, the flexible support member 11 is designed in an oval shape, and the magnesium alloy material. 为了更好的保证刚性支撑部件12的力学性能,将刚性支撑部件12设计成菱形,且材质采用医用不锈钢或钴铬合金。 In order to better ensure the mechanical properties of the rigid support member 12, the rigid support member 12 is designed in a diamond shape, and the material used for medical stainless steel or cobalt-chromium alloy.

[0020] 所述连接件2为直线连接杆,支撑单元I之间采用直线连接杆,使得血管支架在扩张后既能保持较高的径向支撑力,又具有轴向零缩短,有利于提高血管支架植入后的定位精度以及更进一步减少支架注入对血管壁的损失率。 [0020] The connecting member 2 is a straight line connecting rod, the connecting rod using a straight line between the supporting unit I, so that the vascular stent keeps productivity high radial force in the expansion, but also have a zero axial shortening help improve positioning accuracy of the vascular stent and stent implantation to further reduce the loss of the vessel wall.

[0021] 优选地,所述柔性支撑部件11的长径与短径之比为3:2。 [0021] Preferably, the ratio of the major axis and the minor axis of the flexible support member 11 is 3: 2.

[0022] 优选地,所述血管支架的长度为2_30cm。 [0022] Preferably, the length of the stent 2_30cm.

[0023] 以上已以较佳地实施例公布了本发明,然其并非用以限制本发明,凡采取等同替换或等效变换的方案所获得的技术方案,均落在本发明的保护范围内。 [0023] In the above embodiments preferably has released the present invention, they are not intended to limit the present invention, all equivalent technical solutions adopted substitutions or equivalent transformation of the obtained solutions, all fall within the scope of protection of the present invention .

Claims (7)

  1. 1.一种防止血管再狭窄的血管支架,其特征在于:所述血管支架为管状,包括沿轴向均匀分布的若干个支撑单元、将若干个所述支撑单元连接一起的连接件,所述支撑单元包括柔性支撑部件以及内接在所述柔性支撑部件内的刚性支撑部件。 1. A method of preventing restenosis of a blood vessel stent, wherein: said vessel is a tubular stent, comprising a number of support units uniformly distributed along the axial direction, the support unit to a plurality of connection members together, said a support means comprises a rigid support member and an inner member connected to the flexible support within the flexible support member.
  2. 2.根据权利要求1所述的防止血管再狭窄的血管支架,其特征在于:所述柔性支撑部件为椭圆形,所述刚性支撑部件为菱形。 The blood vessel to prevent restenosis of the stent as claimed in claim 1, wherein: said flexible support member is elliptical, the rigid support member is a diamond.
  3. 3.根据权利要求2所述的防止血管再狭窄的血管支架,其特征在于:所述柔性支撑部件的长径与短径之比为3:2。 3. The preventing restenosis stent of claim 2, wherein: said flexible support member than the major axis and the minor axis is 3: 2.
  4. 4.根据权利要求1所述的防止血管再狭窄的血管支架,其特征在于:所述柔性支撑部件的材质为镁合金。 The blood vessel to prevent restenosis of the blood vessel stent 1 claim, wherein: said flexible support member is made of a magnesium alloy.
  5. 5.根据权利要求1所述的防止血管再狭窄的血管支架,其特征在于:所述刚性支撑部件的材质为医用不锈钢或钴铬合金。 The blood vessel to prevent restenosis of the stent as claimed in claim 1, characterized in that: the rigid support member is made of medical stainless steel or cobalt-chromium alloy.
  6. 6.根据权利要求1所述的防止血管再狭窄的血管支架,其特征在于:所述连接件为直线连接杆。 The blood vessel to prevent restenosis of the stent as claimed in claim 1, wherein: said connecting member is a straight line connecting rod.
  7. 7.根据权利要求1-6任意一项所述的防止血管再狭窄的血管支架,其特征在于:所述血管支架的长度为2-30cm。 According to any one of claims 1-6 preventing vascular stent restenosis, as claimed in claim wherein: said stent length is 2-30cm.
CN 201510132130 2015-03-25 2015-03-25 Vascular support for preventing vascular restenosis CN104814820A (en)

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US6200337B1 (en) * 1996-03-10 2001-03-13 Terumo Kabushiki Kaisha Implanting stent
WO1998007386A1 (en) * 1996-08-22 1998-02-26 Thomas Ischinger Tubular stent
EP0873728A2 (en) * 1997-04-25 1998-10-28 W.C. Heraeus GmbH Radial expandable support device (stent) II
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106580528A (en) * 2017-02-04 2017-04-26 成都鼎信致远科技有限公司 Coronary stent for preventing restenosis

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