CN104771200B - Intracranial aneurysm neck reconstruction device - Google Patents

Intracranial aneurysm neck reconstruction device Download PDF

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Publication number
CN104771200B
CN104771200B CN201510179045.4A CN201510179045A CN104771200B CN 104771200 B CN104771200 B CN 104771200B CN 201510179045 A CN201510179045 A CN 201510179045A CN 104771200 B CN104771200 B CN 104771200B
Authority
CN
China
Prior art keywords
device body
reconstructing device
reconstruction device
aneurysm
neck
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201510179045.4A
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Chinese (zh)
Other versions
CN104771200A (en
Inventor
黄清海
刘建民
沈洁
王驰
吕楠
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Second Military Medical University SMMU
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Second Military Medical University SMMU
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Publication date
Application filed by Second Military Medical University SMMU filed Critical Second Military Medical University SMMU
Priority to CN201510179045.4A priority Critical patent/CN104771200B/en
Publication of CN104771200A publication Critical patent/CN104771200A/en
Application granted granted Critical
Publication of CN104771200B publication Critical patent/CN104771200B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027Type of occlusion
    • A61B17/12031Type of occlusion complete occlusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape

Abstract

The invention relates to an intracranial aneurysm neck reconstruction device. The intracranial aneurysm neck reconstruction device comprises a reconstruction device body, a guide wire and an outer sheath tube, wherein the reconstruction device body gradually and outwards expands from the near end to the far end; the far end of the reconstruction device body is provided with a head end developing block; the middle end of the reconstruction device body is provided with a middle end developing block; the near end of the reconstruction device body is folded downwards and is fixedly arranged on the guide wire; the guide wire is positioned in the outer sheath tube; a disconnecting point is arranged at the connected position of the guide wire and the reconstruction device body; the other end of the guide wire is connected with a disconnector. The intracranial aneurysm neck reconstruction device disclosed by the invention has the advantages that by implanting the reconstruction device body, the flowing speed of blood in an intracranial aneurysm is slowed down, the hemodynamics in the intracranial aneurysm is changed, and thus the impact from local blood flowing to an aneurismal wall can be reduced; meanwhile, through the implantation of a parent artery reconstruction device body, a local parent artery can be strengthened and repaired, and the physiological structure of a normal part of the parent artery is enabled to recover.

Description

Intracranial aneurysm neck reconstructing device
Technical field
It is a kind of intracranial aneurysm neck reconstructing device specifically the present invention relates to technical field of medical instruments.
Background technology
Intracranial aneurysm is that it is a kind of pathogenicity rate high due to the encephalic angioma sample projection that local vascular abnormal change is produced It is the main cause for causing subarachnoid hemorrhage, the intracranial aneurysm death rate of rupture with the cranial vascular disease of fatal rate high Up to 51%, the disability rate of Survivor is close to 50%.It is treatment of intracranial aneurysm that surgical clamp is closed with intravascular Interventional Treatment Two kinds of major ways.With the development that intervention apparatus are swift and violent, intracranial aneurysm PCI due to it is minimally invasive, safely, have The advantages of effect, it has also become the first-selected clinical treatment of current many hospitals.
The principle of PCI is clogged by mechanicalness, changes local hemodynamic studies factor, and secondary thrombus is formed, mesh Various embolization devices have been developed on former world for treating aneurysm, such as turn, is guided by intubation intervention To in aneurysm, aneurysmal space is filled, thrombus is formed in a short time, reduced blood and directly aneurysmal arm is rushed Hit, so as to prevent aneurysm rupture.
But it is aneurysmal come in every shape, clogged using turn incomplete, cause aneurysm to be led to again, excessively filling causes Aneurysm rupture, turn protrudes Aneurysmal neck influence parent artery blood flow.With the development of interventional technique, support auxiliary bullet The appearance of spring coil embolism entocranial artery technology, is discharged at knurl neck by support, and the release spring circle in aneurysm cavity, branch is mounted In the arteries in aneurysm, turn can be prevented from protruding aneurysm.
Chinese patent literature CN201320036422.5, at 24 on the applying date 2013 year 01 month, patent name is for " encephalic is from swollen Swollen stage peritonaeum braided support ", discloses a kind of encephalic self-expanding stage peritonaeum braided support, including braided support, its feature It is to be provided with support overlay film, the braided support is that a B alloy wire two ends are risen to the other end by axially and radially from one end respectively The net tubular bracket worked out is intersected around and circulated, volume is made in cylinder, two ends flare in the middle of establishment support Knit and closed loop configuration is formed between the mesh of support and mesh, increased the radial support power at two ends, the both ends of the surface of braided support B alloy wire is curved, it is to avoid puncture intracranial vessel, and the cylindrical surface of braided support is covered with support peritonaeum, it is to avoid blood flow is to cranium Interior hemangioma neck is impacted, while avoiding the filling turn in aneurysm knurl chamber from protruding and block arteries, is reached and is added Fast inner membrance growth rate, makes aneurysm quickly complete inaccessible effect.
The overlay film frame is applied to the aneurysm of huge treatment encephalic, neck wide or fusiformis, but for the load of some furcations Knurl artery or opening are difficult to send into intracranial target close to the parent artery of bifurcated.
Reconstructing blood vessel device is one of focus of current intracranial aneurysm apparatus research and development, in aneurysm, knurl neck Forming part is the position that parent artery constructs that defect and local hemodynamic conflict are concentrated the most, therefore, densification filling knurl Neck, recovers the integrality of local parent artery, is to repair parent artery, treat aneurysmal premise and basis, but existing skill Fine and close filling knurl neck generally selects turn in art, and its Coil embolization is very fine and close, is easily caused aneurysm rupture;In addition, Aneurysm is the result of parent artery lesion, and repairing parent artery helps to reduce aneurysm recurrence.
In sum, a kind of promotion thrombosis is needed badly, compactness filling knurl neck slows down blood flow velocity in aneurysm, The haemodynamics in aneurysm is changed, reduce impact of the regional flow to knurl wall, reinvent parent artery, strengthen, repair The Aneurysmal neck reconstructing device of multiple part parent artery, and yet there are no report on this Aneurysmal neck reconstructing device Road.
The content of the invention
The purpose of the present invention is directed to deficiency of the prior art, there is provided one kind promotes thrombosis, compactness filling knurl Neck, slows down blood flow velocity in aneurysm, the haemodynamics in aneurysm is changed, and reduces regional flow to knurl wall Impact, reinvents parent artery, strengthens, repairs the Aneurysmal neck reconstructing device of local parent artery.
To achieve the above object, the present invention is adopted the technical scheme that:
A kind of intracranial aneurysm neck reconstructing device, the knurl neck reconstructing device includes reconstructing device body, seal wire, epitheca Pipe;The reconstructing device body is woven into net by the wire with SME or with elastomeric macromolecule silk material Hole, its mesh form is rhombus;The mesh winds for waveform;For hollow out is three-dimensional under the reconstructing device body deployed condition Structure;The reconstructing device body distal end is provided with head end developing block, and the reconstructing device body middle-end is provided with middle-end developing block;Institute Reconstructing device body distal end ovalize is stated, the near-end of the reconstructing device body draws in be fixed on seal wire downwards;It is described to lead Silk is located in outer sheath;The seal wire is provided with reconstructing device body junction frees a little;The other end connection solution of the seal wire De- device.
Convex on the outside of the mesh, inner side concaves.
The reconstructing device body proximal end is gradually expanded outwardly to reconstructing device body distal end.
The reconstructing device body is in " infundibulate ", and its lower end can be recessed into " arc " upwards.
The invention has the advantages that:
1st, a kind of intracranial aneurysm neck reconstructing device of the invention, by being implanted into reconstructing device body, slows down blood and exists Flow velocity in aneurysm, makes the haemodynamics in aneurysm change, and reduces impact of the regional flow to knurl wall, hence it is evident that reduce Aneurysmal recurrence rate, promotes the dissection healing of knurl neck;
2nd, by being implanted into reconstructing device body, strengthen, repair local parent artery, promote to recover aneurysm normal portions Physiological structure, realizes the reconstruction that lesion parent artery is repaired;
3rd, the fibrocyte synthesis in reconstructing device body implantation section arterial wall, secretion are stimulated after the implantation of reconstructing device body Collagenous fibres, there is obvious repairing, invigoration effect to local parent artery, while increase support force to being not yet implanted into a section cell, Be conducive to repairing local parent artery defect, prevent aneurysmal recurrence;
4th, reconstructing device body promotes thrombosis, compared with Coil embolization, it is possible to reduce turn consumption, reduces Because excessively filling causes aneurysm rupture in art;
5th, from regulatable infundibulate reconstructing device body, it is adaptable to which furcation parent artery and single channel carry knurl and move Arteries and veins;
6th, using the aobvious developing block of head end and middle-end developing block can visual control reconstructing device body shape.
Brief description of the drawings
Accompanying drawing 1 is a kind of intracranial aneurysm neck reconstructing device structural representation of the invention.
Accompanying drawing 2 is the structural representation that a kind of intracranial aneurysm neck reconstructing device of the invention is placed in furcation parent artery Figure.
Accompanying drawing 3 is the structural representation that a kind of encephalic reconstructing device of the invention is placed under single channel parent artery state.
Specific embodiment
The specific embodiment that the present invention is provided is elaborated below in conjunction with the accompanying drawings.
The reference and part being related in accompanying drawing are as follows:
1. the mesh of reconstructing device body 11.
The middle-end developing block of 12. head end developing block 13.
2. the outer sheath of seal wire 3.
4. a little 5. release is freed
6. the parent artery of aneurysm 7.
Embodiment 1
For the ease of description, below description has used term " distal end " and " near-end ", wherein distal end be from aneurysm farther out One end, near-end is the one end close to aneurysm.
Fig. 1 is refer to, Fig. 1 is a kind of intracranial aneurysm neck reconstructing device structural representation of the invention.A kind of encephalic Aneurysmal neck reconstructing device, the knurl neck reconstructing device includes reconstructing device body 1, seal wire 2, outer sheath 3;It is described to rebuild dress Put body 1 and be woven into mesh by the wire with SME or with elastomeric macromolecule silk material, its mesh 11 Rhombus is shaped as, the outside convex of whole mesh 11, inner side concaves, is closed loop configuration between mesh 11;The reconstructing device sheet It is hollow out stereochemical structure under the deployed condition of body 1, the near-end of reconstructing device body 1 is gradually outside to the distal end of reconstructing device body 1 Expansion;The distal end of reconstructing device body 1 is provided with head end developing block 12, and the middle-end of reconstructing device body 1 is provided with middle-end development Block 13;The distal end ovalize of the reconstructing device body 1, the near-end of the reconstructing device body 1 draws in be fixed on seal wire 2 downwards On;The seal wire 2 is located in outer sheath 3;The seal wire 2 and the junction of reconstructing device body 1 are provided with frees a little 4;The seal wire 2 The other end connection release 5.
Fig. 2 is refer to, Fig. 2 is that a kind of encephalic kind Aneurysmal neck reconstructing device of the invention is placed in furcation parent artery Structural representation.When the reconstructing device body 1 is placed in furcation aneurysm, its reconstructing device body 1 is located in knurl chamber, whole Individual reconstructing device body 1 be in " infundibulate ", the near-end of reconstructing device body 1 downwards draw in a bit, the proximal lateral of reconstructing device body 1 Fitted with the inwall of parent artery 7 of furcation in face.
Fig. 3 is refer to, Fig. 3 is the structural representation that a kind of encephalic reconstructing device of the invention is placed in single channel parent artery Figure.When the reconstructing device body 1 is placed in single channel parent artery 7, whole reconstructing device body 1 is located in knurl chamber, rebuilds dress Put the lower end of body 1 to be recessed into upwards " arc ", middle-end developing block 13 is fitted with knurl neck.
It should be noted that:The reconstructing device body 1 is woven into mesh by multi-filament material, with good dilatancy, Superior coverage rate;The reconstructing device body 1 is woven into the mesh 11 of " rhombus " shape, when its reconstructing device body 1 launches, axle It is low to LVFS;The reconstructing device body 1 selects the effect or elastomeric macromolecular material of shape memory, with good Elastic reaction;Using waveform canoe, reconstructing device body 1 in the deployed state when, radial support power is good, it is not easy to become Shape, it is ensured that reconstructing device body 1 is brought into close contact with the inwall of aneurysm 6;The outside convex of mesh 11 of the reconstructing device body 1 Inner side concaves, and the permeability of reconstructing device body 1 is good, and blood is easily flowed into reconstructing device body 1, reduces regional flow to knurl The impact of neck;And the blood in reconstructing device body 1 is not easy outflow so as to form thrombus, densification filling knurl neck;Described net Being arranged between hole 11 closely can substantially slow down blood flow in aneurysm 6, the vortex and percussion in the knurl chamber of aneurysm 6 be reduced, by one After fixing time, Excessive intimal rises to climbs the completely whole surface of reconstructing device body 1, finally completely encloses aneurysm 6;The reconstruction Device body 1 stimulates the fibrocyte synthesis that reconstructing device body 1 is implanted into section arterial wall after being implanted into, secrete collagenous fibres, right Local parent artery 7 has obvious repairing, invigoration effect, while increasing support force to being not yet implanted into a section cell, is conducive to repairing The defect of local parent artery 7, prevents the recurrence of aneurysm 6.
There is the head end developing block 12 and middle-end developing block 13 of the reconstructing device body 1 positioning to indicate in a state of use Effect, by head end developing block 12 and middle-end developing block 13 can visual control reconstructing device body 1 launch size, judge whether with Knurl neck inwall is fitted;When aneurysm 6 be located at furcation parent artery or opening close to bifurcated parent artery 7 when, release Reconstructing device body 1 is infundibulate so that the side of reconstructing device body 1 is fitted with the inwall of parent artery 7 of furcation, works as artery When knurl 6 is located at single pass parent artery 7, the lower end of release reconstructing device body 1 is recessed into " arc " upwards, and causes that middle-end shows The position of shadow block 13 is fitted with knurl neck, and aneurysm 6 can be prevented to be downwardly projected, and influences the mobile performance of parent artery 7, or is avoided Aneurysm 6 is downwardly projected the thrombus to be formed and blocks parent artery 7.
The described positive pole of release 5 is connected on the exposed area of the metal of delivery guidewire 2 of reconstructing device body 1, negative pole with free Subcutaneous draw point near point connects, and adjusts current/voltage and the time of release 5 so that reconstructing device body 1 is freeing a little 4 Free.
A kind of intracranial aneurysm neck reconstructing device application method of the invention is:Encephalic is determined by angiogram first The position of aneurysm 6, microtubular is super choose position after, reconstructing device body 1 is delivered in aneurysm 6 through microtubular, by head end Developing block 12 determines the position of reconstructing device body 1.Then period reconstructing device body 1 withdraws epitheca always situated in outer sheath 3 The release reconstructing device of pipe 3 body 1, because the SME of the metal of shape memory or the elasticity of high resiliency molecular material are made With reconstructing device body 1 is transformed into expanded position by the intrinsic radial support power of material.Be expanded to middle-end developing block 13 with Aneurysm neck is fitted, if during for the aneurysm for treating furcation, release reconstructing device body 1 omits near-end to infundibulate Charge into aneurysm 6 as shown in Figure 1;If for it is single pass load knurl artery when, according to the form of aneurysm 6 and position release weight Device body is built, and middle-end developing block is overlapped with aneurysm neck, seal wire 2 is pushed forward, near-end fixing point is charged into aneurysm 6 It is interior as shown in Figure 2.A little free reconstructing device body 1 finally by freeing, seal wire 2 and outer sheath 3 are withdrawn from vitro.
A kind of intracranial aneurysm neck reconstructing device of the invention, by being implanted into reconstructing device body 1, slows down blood dynamic Flow velocity in arteries and veins knurl 6, makes the haemodynamics in aneurysm 6 change, and reduces impact of the regional flow to knurl wall, hence it is evident that reduce The recurrence rate of aneurysm 6, promotes the dissection healing of knurl neck;By being implanted into reconstructing device body 1, reinforcement, the local knurl that carries of reparation are moved Arteries and veins 7, promotes to recover the physiological structure of the normal portions of parent artery 7, realizes the reconstruction that lesion parent artery 7 is repaired;Reconstructing device Body 1 stimulates the fibrocyte synthesis in reconstructing device body implantation section arterial wall after being implanted into, collagenous fibres are secreted, to local load Knurl artery 7 has obvious repairing, invigoration effect, while increasing support force to being not yet implanted into a section cell, is conducive to repairing local load The defect of knurl artery 7, prevents aneurysmal recurrence;Reconstructing device body 1 promotes thrombosis, compared with Coil embolization, can be with Turn consumption is reduced, is reduced in art because excessively filling causes aneurysm rupture;Rebuild from regulatable infundibulate and filled Put body 1, it is adaptable to parent artery 7 and single channel parent artery 7;Can be straight using the aobvious developing block 12 of head end and middle-end developing block 13 See the shape of control reconstructing device body.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as Protection scope of the present invention.

Claims (2)

1. a kind of intracranial aneurysm neck reconstructing device, it is characterised in that the knurl neck reconstructing device include reconstructing device body, Seal wire, outer sheath;The reconstructing device body is by the wire with SME or with elastomeric macromolecule silk Material is woven into mesh, and its mesh form is that arrangement is tight between rhombus, mesh;The reconstructing device body is in " infundibulate ", under it End can be recessed into " arc " upwards;The mesh winds for waveform;Convex on the outside of the mesh, inner side concaves;It is described heavy Build under device body deployed condition as hollow out stereochemical structure;The reconstructing device body distal end is provided with head end developing block, described heavy Build device body middle-end and be provided with middle-end developing block;The reconstructing device body distal end ovalize, the reconstructing device body Near-end draws in be fixed on seal wire downwards;The seal wire is located in outer sheath;The seal wire sets with reconstructing device body junction Have and free a little;The other end connection release of the seal wire.
2. knurl neck reconstructing device according to claim 1, it is characterised in that the reconstructing device body proximal end is filled to rebuilding Body distal end is put gradually to expand outwardly.
CN201510179045.4A 2015-04-15 2015-04-15 Intracranial aneurysm neck reconstruction device Expired - Fee Related CN104771200B (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN104771200B true CN104771200B (en) 2017-05-24

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US10433826B2 (en) 2014-12-15 2019-10-08 Vivasure Medical Limited Closure apparatus with flexible sealable member and flexible support member
CN108697414B (en) * 2015-12-15 2022-02-01 维瓦舒尔医疗设备有限公司 Arteriotomy closure device with slotted shoe to achieve advantageous pressure distribution
CN110507380A (en) * 2018-05-22 2019-11-29 黄清海 A kind of intracranial aneurysm auxiliary embolization device
CN116831679B (en) * 2023-09-02 2023-11-14 杭州亿科医疗科技有限公司 Aneurysm vortex device easy to release

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