CN1047512C - Gastrointestinal electric signal detection processing device and method - Google Patents

Gastrointestinal electric signal detection processing device and method Download PDF

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CN1047512C
CN1047512C CN 93102318 CN93102318A CN1047512C CN 1047512 C CN1047512 C CN 1047512C CN 93102318 CN93102318 CN 93102318 CN 93102318 A CN93102318 A CN 93102318A CN 1047512 C CN1047512 C CN 1047512C
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electrode
signal
gastrointestinal
frequency
electrodes
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CN1079379A (en
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徐文洁
鲍健
袁士平
王斯林
钱宜乐
傅忠
阎建国
梅艳
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HEFEI DIVISION CHINESE ACADEMY OF SCIENCES
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Abstract

The invention relates to a gastrointestinal electric signal detection processing device and a method, comprising the following steps: the detection processing device comprises a detection electrode, an analog signal device, a digital signal device, a data recording device, an ammeter monitoring device, a switch control device, a power supply and the like, wherein all electrodes adopt concave silver-silver chloride electrodes; the detection method adopts a single-pole test method. The device and the method can be used for gastrointestinal electric signal detection and Fourier spectrum analysis, can be used for continuous multi-channel acquisition, can automatically analyze according to blocks, gives average amplitude, average frequency and the like, and can be used together with a PC (personal computer). The invention is a medical intelligent high-tech product, and has the advantages of convenient use, high cost performance and the like.

Description

Detecting-processing apparatus and method for gastointestinal electric signal
The present invention relates to measure the bioelectrical signals of human body parts, particularly the gastrointestinal signal of telecommunication.
The history in existing 70 years of record stomach electricity, because weak output signal, frequency be near direct current, detection difficult, so slower development.The structure that Chinese patent (CN20514950U) discloses a kind of " multiple tracks intelligence gastrointestinal electrographic instrument ", this instrument comprises: a plurality of detecting electrodes; An analog signal instrumentation of forming by electrode interface circuit, signal amplification circuit, filter circuit, power amplifier, a digital signal device of realizing by micro computer; Switching device; Supply unit.The micro computer gastrointestinal electrical information detecting processing system of the common development of Guangzhou Traditional Chinese Medicine College and Zhongshan Medical Univ., this system has a plurality of detecting electrodes, analog signal instrumentation, digital signal device, data recording equipment, switch controlling device and supply unit, its digital signal device can carry out time domain, frequency domain is handled, and power, frequency, time can be described as false three-dimensional the expansion, the outfan of its analog signal instrumentation can link to each other with the physiological signal monitor, with the observation signal real-time change.
A kind of new electric physiological detection, to identify that at first its reaction formation has typicality under special circumstances, confirm identifying that from the dependency between the SA of the signal of telecommunication of skin surface record and organ reliability later on also will be through using, be familiar with the mutual relation between the abnormal response under normal physiological function and different external environments, behavioral aspect and the pathological conditions.
The gastrointestinal electrograph is newer, needs through identifying identification, verifying and use such three phases.The present invention did some basic tests for the relation of stomach electricity in the proof body with stomach electricity of body surface.Once on one's body 9 Canis familiaris L.s, silver electrode is placed on the relevant position of serous coat in the Canis familiaris L. body with surgical operation, with polygraph and Electrogastrograph meter record simultaneously, both all trace out normal stomach electricity, and the rhythm and pace of moving things is per minute 5 times, then the gastrin (Pentagastrin) of the excited stomach electricity of intravenous injection, the egg frequency of record is accelerated, honeybee voltage increases, and intravenous injection suppresses the atropine (atropinc) of stomach electricity, and the stomach electricity amplitude of record reduces.Test on one's body 8 health volunteers again, the experimenter is on an empty stomach more than six hours, at epigastrium body surface continuous record stomach electricity (3cpm), intravenous injection anticholinergic agents that (Buscopan) 20mg then, after 3 minutes, repeat the electrographic recording of abdomen body-surface stomach, the result is that the anticholinergic buscopan has suppressed stomach electric amplitude.Also survey the stomach electricity implementing on the person of stomach resecting operation, find, can not see the frequency component of tangible 3cpm (inferior/minute), tangible 3cpm frequency component is arranged at the residual position of stomach at the position of stomach excision.Show the variation of gastric electrical activity in the accurate antimer of stomach electric energy thus.The present invention is through a large amount of health screenings and clinical case contrast, and is constantly perfect, reaches and faces the mill requirement.
One object of the present invention is exactly that a kind of checkout gear that can the synchronous detecting gastrointestinal signal of telecommunication will be provided.
Another object of the present invention just provides a kind of device that can carry out time domain, frequency domain processing to the multichannel gastrointestinal signal of telecommunication.
A further object of the present invention just provides the method for detection and the processing relevant with said apparatus.
Gastrointestinal electrical signal detection blood processor of the present invention comprises:
A plurality of detecting electrodes: different with the detecting electrode of brain common in prior art electricity and electrocardio etc. is, the present invention adopts concave surface silver-silver chloride electrode, they are placed on the gastrointestinal different parts, just the ion current in the Biomedia can be converted to the electron stream of circuit.The present invention adopts an ear electrode as public reference electrode, and a limb electrode is as ground electrode, and a plurality of external electrodes are as the Validity Test electrode, and a plurality of electrodes connect with the box that leads.
An analog signal instrumentation: a fan-in network links to each other with a plurality of detecting electrodes by the box that leads, and forms the output signal of multidiameter delay; A multichannel amplifying circuit links to each other with the also line output of fan-in network, and each passage amplifies separately, and the line output amplifying signal; A multichannel active bandwidth-limited circuit, each passage links to each other with an amplifier, exports the signal of particular frequency range separately; A multichannel level shifting circuit; Each passage links to each other with a wave filter, makes the level match of output signal and microcomputer input port.
A digital signal device:
A sample circuit is with the synchronized sampling of fixed frequency control analogue signal.
A multichannel mould-number conversion circuit, each road input links to each other with the output of multichannel filter circuit, and analog signal conversion is become digital signal.
A data blood processor carries out digital filtering to digital signal, and time domain, frequency domain, the processing of operation collection of illustrative plates, calculating parameter.
Data recording equipment:, paint oscillogram, spectrogram, operation collection of illustrative plates, recording parameters by color plotter by LPT output result of calculation.
An ammeter monitoring arrangement: promptly one group of voltmeter is received each road analog signal output, make the real-time change of operator's energy observation signal, be convenient to the operator and discern correct signal, remove and disturb, guarantee to test successfully, after signal is steady, could press and measure key, big dynamic disturbance occurs, end test, treat stable survey again later on.
Switch controlling device: passage and the working method of being convenient to operator's selective amplifier; it has one group of switching network that leads; box links to each other with amplifier with electrode by leading; play gating and input protection effect; also have one group of gain switch network, select the amplification on each road, select the passband and the decision working method of gastrointestinal test circuit; can survey stomach, intestinal separately, perhaps survey the harmonization of the stomach intestinal simultaneously.
A supply unit comprises:
The power supply of an analog signal instrumentation,
The power supply of a digital signal device,
The power supply of a data recording equipment.
The power supply of a data communication device.
Gastrointestinal electric detection means of the present invention also further comprises:
Described analog signal instrumentation comprises:
Multichannel amplifier selects for use one group of operational amplifier to constitute the high-acruracy survey amplifier.Sort circuit is used widely in Detection of Weak Signals.It has low maladjustment voltage, low coefficient of deviation, stable amplification and the characteristics of low output impedance.
Adopt general RC circuit and step low-pass active filter circuit to form band filter, also have level shifting circuit.
Gastrointestinal electric detection means of the present invention also comprises:
Described digital signal device comprises: internal data handling equipment, and external data processing device, the contact of two parts realizes by communication device, selects different functions by keyboard with display device simultaneously.Internal data handling equipment can be formed main frame with a plurality of detecting electrodes, analog signal instrumentation, recording equipment, ammeter monitoring arrangement, switch controlling device, uses separately, can portable work.This minute body structure and online occupation mode can satisfy the customer requirements of different levels, to popularizing and promote instrument effect are arranged.
Internal data handling equipment is made of single chip microcomputer, comprise a time domain processing unit and a frequency domain processing unit, the processing unit of an operation collection of illustrative plates, gather, handle time-domain signal, simultaneously each road signal is carried out 1024 Fourier spectrum analyses, calculate their power spectrum function, signal is carried out zone detection, segmentation is calculated, and power spectrum opened up function into the time, frequency, power, time are described as false three-dimensional the expansion, solve the difficult problem of follow-on test, analysis, record, all figures, parameter are all exported record.
External data processing device is an outside computer that internal memory is big, speed is fast, function is complete, working method at the operation collection of illustrative plates, automatically finish the information transmission, deposit data in disk in real time, and on display synchronously display graphics, satisfy the requirement of large hospital, be convenient to handle afterwards and constitute specialist system, also can transmit simultaneously with the data of inside and outside data processing equipment of function key control.
The communication device that the communication of inside and outside data processing equipment is made up of RS-232 serial port of one group of photoswitch, one group of transmission circuit and a standard is finished.By the function of a function keyboard control survey, drawing, operation collection of illustrative plates and communication, by two nixie display indication monitoring duties, if be in monitor state, function keyboard works, the ongoing function of work dial gauge showing device simultaneously.
Gastrointestinal electrical signal detection method of the present invention comprises the steps:
(1) detects by the signal of a plurality of detecting electrodes the gastrointestinal different parts.
(2) by a multichannel amplification, filter circuit the signal that detects is amplified and and line output.
(3) sample circuit provides the synchronized sampling frequency, and analog digital conversion is converted to the multi-path digital signal with multichannel analog signals.
(4) data with sampling deposit buffer register in.
(5) signal processing apparatus takes out sampled data from the buffering depositor, the filtering of advanced line number word, and time domain is handled then, frequency domain is handled again, realizes 1024 Fourier spectrum analysis, to obtain corresponding curve and calculating parameter.
(6) by " drawing key ", output device is with above-mentioned curve and parameter output, by recording device records.
Gastrointestinal electrical signal detection processing method of the present invention also further comprises
The frequency curve of described signal processing means processes adopts automatic spectral analysis technology to show.The coordinate of seeing spectral intensity on frequency spectrum does not have the scalar degree, because the dynamic range of signal is 10~1200 microvolts, the excursion of enhancing degree reaches 214.Can not in a little figure, show, when analysis of spectrum was painted spectrogram exactly automatically, power spectrum intensity was standard by automatic gain control (record multiplying power m) with the full lattice of peak power spectral intensity, make all frequency spectrums of energy clear display of very strong and very weak signal, passband signal in addition also can be shown.
Gastrointestinal electrical signal detection processing method of the present invention also further may further comprise the steps:
(1) needs the long-time interdigestive phase of studying gastrointestinal motility, just, above-mentioned steps can be repeated 18 times by " operation collection of illustrative plates " key, continuous record 2 hours, auto-partition section detection signal, each section 6 minutes and 40 seconds, the step of the detection of each section, processing, tracer signal is as above.The signals collecting of each section, date processing are independently, and continuous record in time just can be expanded spectrogram false three-dimensional expansion for amplitude, frequency, time.
If operator's nonintervention can repeat 18 times, continuous record 2 hours, be necessary to quit work if the operator thinks, can after surveying once, have surveyed in any time before the 18 time, once more by same " operation collection of illustrative plates " key, just can cease operation, print result.
(2) in " operation collection of illustrative plates " duty: the communication device is finished the transfer of data of internal data handling equipment and external data processing device automatically.
(3) external data processing device: deposit the data that transmit in disk automatically.
(4) external data processing device synchronous display graphics on display.
(5) end " operation collection of illustrative plates " work, can control as required by the operator.
The feature of gastrointestinal electrical signal detection of the present invention and processing method also comprises electrode and method of testing:
Adopt the one pole method of testing, the ear electrode is placed on ear-lobe or the signal effective reference point of mastoid process, uses limb electrode ground connection, uses external electrode as the Validity Test electrode.
Mechanism from test, the record bio electricity is used difference amplifier, only when presenting the algebraically voltage difference, could amplify two inputs of amplifier, the pair of electrodes that is connected to two inputs of an amplifier is called one and leads, if when connecting with a plurality of electrodes, a plurality of amplifiers have a public input, i.e. effective reference point correctly selects this point ten minutes important.
An active electrode and a reference electrode are the one pole test, two active electrodes are bipolar method of testing, external a lot of report thinks that bipolar method of testing is good, it has electrocardio, breathing, the motion artifacts of maximum amplitude, minimum, think that bipolar test has maximum signal to noise ratio, select umbilicus and xiphoid-process mid point to be best effective reference point.What we were a large amount of facts have proved, the result is not like this.Normal or basic normal people says to the stomach function; the each several part coordination exercise of stomach; bipolar test is similar to the result of one pole test; the dominant frequency unanimity; amplitude does not significantly increase, but surveys gastric disease patient's clectrogastrogram with bipolar method of testing, sees that amplitude obviously increases; waveform distributes with spectrum and changes, and bipolar test result is difficult to judge.Because the position of many people's gastric antrum end and umbilicus, xiphoid-process mid point matches, if the gastric disease patient, this point is focal zone just, the abnormal signal of itself, it is made reference point, must cause signal inaccurate, this is conspicuous, so bipolar process is a kind of relative measurement, if measure one road signal problem is arranged, problem between tested 2 can only be described, can not accurately show it is which point has problem, conclusion is clear and definite inadequately.Certainly this kind method of testing has the advantage of good in anti-interference performance.Domestic existing stomach electrical testing is as electrocardio, player's wrist inboard is public reference point, and this point is not on tested organ, and therefore the signal of surveying is regular strong, can make clear conclusions, but the gastrointestinal signal of telecommunication is fainter than electrocardio, selects effective reference point in the wrist inboard, intentionally electrical interference, can't detect for a long time, can't study the interdigestive phase of gastrointestinal motility, the effective reference point of therefore correct selection is very important, and this is a factor that influences the development of gastrointestinal electricity.
The present invention with reference to various bioelectric methods of testing, uses the traditional science of channels and collaterals knowledge of China for overcoming artifacts, repeatedly practises, compares, and finds to select for use the ear-lobe or the mastoid process that have nothing to do with tested position good as effective reference point, and this is creation of the present invention.Such test good in anti-interference performance has solved the difficult problem of long-time continuous test, and clinical practice is pushed forward.The method of testing that the present invention proposes is: use an ear electrode to make public reference electrode, and a limb electrode ground connection, many external electrodes are as the Validity Test electrode.The test of multi-lead can improve diagnosis.
Gastrointestinal electrical signal detection blood processor of the present invention and method, Detection of Weak Signals, single chip microcomputer that the utilization recent two decades develops are in the world used and information-theoretical advanced technology, stable test, analysis of science, quantitative parameter, reached the requirement of clinical use, the present invention payes attention to basic research and clinical practice, proves that gastrointestinal electrical signal detection blood processor of the present invention and method can diagnose gastroenteropathy.Make the curative effect monitoring of treatment front and back simultaneously, started the new situation that gastrointestinal electrographic instrument enters internal class hospital, obtained consistent favorable comment, the present invention has broad application prospects.
The above-mentioned purpose that the present invention will reach, other purpose and feature, advantage will know in following description of drawings that the face of land occurs coming.
Fig. 1 is the schematic block diagram of gastrointestinal electrical signal detection blood processor of the present invention;
Fig. 2 is the sketch map of electrode 1 and an embodiment of analog signal instrumentation 2 among Fig. 1;
Fig. 3 (a) is the schematic block diagram of digital signal device 3 among Fig. 1;
Fig. 3 (b) is the internal structure sketch map of single chip microcomputer 310 among Fig. 3 (a);
Fig. 4 is the amplifier circuit figure of analog signal instrumentation among Fig. 1;
Fig. 5 is that Fig. 1 is the circuit diagram of the active band-pass filter of analog signal instrumentation;
Fig. 6 is the schematic configuration diagram of electrode: wherein: 1. box leads; 2. ear electrode; 3. external electrode; 4. limb electrode;
Fig. 7 (a) is normal clectrogastrogram, and Fig. 7 (b) is normal electrocolonogram;
Fig. 8 (a)-8 (d) is the sketch map of operation collection of illustrative plates;
Fig. 9 (a)-9 (d) composes the sketch map of composing with normalizing automatically;
Figure 10 is the workflow diagram of gastrointestinal electrical signal detection blood processor of the present invention;
Figure 11 is the workflow diagram of the data acquisition among Figure 10;
Figure 12 is the workflow diagram when calling the drawing subprogram among Figure 10.
Figure 13 is the workflow diagram that calls service chart music score program among Figure 10.
Figure 14 is the workflow diagram that calls the communication subprogram among Figure 10.
Figure 15 is the panel appearance sketch map of apparatus of the present invention.
Referring to the schematic block diagram that Figure 1 shows that gastrointestinal electrical signal detection blood processor of the present invention, the label 1 expression electrode and the box that leads, electrode structure is seen Fig. 6, and several Validity Test electrodes are arranged, and is exactly several passages, can select according to clinical needs.Analog signal instrumentation of label 2 expressions, its circuit is referring to Fig. 2, Fig. 4, Fig. 5, and label 3 is digital signal devices, and its detailed structure is referring to Fig. 3 (a) Fig. 3 (b), and label 4 is represented data recording equipments, the output result of drawing data system.Label 5 expression ammeter monitoring arrangements are convenient to the variation of operator's observation signal.Label 6 expression switch controlling devices, control channel selection, amplification, working method.Label 7 expression supply units guarantee system's operate as normal.
Referring to Fig. 2, be depicted as the sketch map of electrode among Fig. 11 and the embodiment of analog signal instrumentation 2.Among Fig. 2,10s represents the ear electrode, 10J represents ground electrode, 101~10n represents n effectively detecting electrode, wherein digital n selects according to clinical needs, and label 111 is the box that leads, and label 112 is the connecting pin seat, a plurality of electrodes are by the box that leads, and union joint is connected to the input combinational network of analog signal instrumentation 2.Because the gastrointestinal signal of telecommunication is very faint, each link that therefore will pay attention to testing, not only counter electrode has strict requirement, and the contact resistance of require simultaneously to lead box and union joint is little, connects reliably.A plurality of detecting electrode 10S, 10J, 101~10n is placed on human or animal's body surface corresponding to the gastrointestinal different parts, the while detection signal, youngster's Validity Test electrode is arranged, several analog signal channels are just arranged, the multidiameter delay output of combinational network 201 is connected with a plurality of preamplifiers 202 of multichannel amplifying circuit, the pair of electrodes that is connected to an amplifier is called one and leads, adopt the one pole method of testing, the connected mode of combinational network is, the amplifier of a plurality of passages has a public input, as effective reference point, be ear electrode 10S, also have common safety ground point, i.e. an electrode 10J, 101~10n n effectively detecting electrode imports another input independently of the preamplifier of n each passage in the passage respectively, from taking out the signal of each different parts here.The abdominal skin projected area that optimum electrode riding position should be stomach or colon, not exclusively definite in the intravital position of people because of gastrointestinal, the gastrointestinal motility rule is very complicated again, and accurately test has some difficulties, therefore must use multipole test, improves diagnosis.Because weak output signal, for guaranteeing the long-time steady operation of amplifier, the scheme of taking classification to amplify, multichannel preamplifier shown in label among Fig. 2 202, requirement has low noise, the characteristic of low drift, each road output of a plurality of preamplifiers 202 also is advanced into that each road of multichannel amplifier circuit is main puts 203, link to each other with multichannel first order wave filter 204 again, and then link to each other with multichannel second level wave filter 205, at last, multichannel amplifies, the output of filtering, through multichannel level shifting circuit 206, enter the multichannel analog-digital commutator 313 of digital signal device 3.Secondary filtering is for suppressing to disturb the scheme of taking effectively, the gain of each channel amplifier, passband width, according to the different requirements of surveying stomach, intestinal, the operator artificially selects by ON-OFF control circuit, for guaranteeing correct test, each road analogue signal filtering output end connects a voltmeter, the variation of Real Time Observation signal.Supply unit 7 guarantees system's operate as normal.
In Fig. 3 (a), be depicted as the structural representation of digital signal device 3 among Fig. 1.Among Fig. 3 (a), the internal data processing system is made up of single chip microcomputer 310, programmable storage EPROM311, data storage RAM312, clock sampling circuit 314, multichannel analog digital conversion 313, output LPT 316, keyboard 317, nixie display 318, serial port 315, photoelectric isolating circuit 319,320, receiving circuit 321, transtation mission circuit 322.The external data processing system is made of fast, the capacious computer 330 of speed, it have standard RS-232 serial port 331, link to each other with the serial port 315 of single chip microcomputer 310 by photoelectricity isolation, transmission circuit, software control workflow by computer, the analog-to-digital input of multichannel is from the multidiameter delay output of analog signal instrumentation 2, the data process LPT 316 that test analysis is later, export recording equipment 4 to, paint oscillogram, spectrogram, record parameters.
Referring to Fig. 3 (b), be depicted as the internal structure sketch map of single chip microcomputer 310 among Fig. 3 (a).Single chip microcomputer by central processing unit CPu3101, data storage 3103, programmable input/output port 3106, programmable serial port 3104, vibration and intervalometer 3102, regularly-enumerator 3104, also have specific function controller 3105 compositions such as grade of expansion.Single chip microcomputer can have inner data storage and program storage, can also enlarge capacity with the outer data of sheet, program storage, satisfies user's various requirement.Single chip microcomputer is the product of large scale integrated circuit, whole or most of functional parts of its integrated electronic computer on chip piece, be formed by connecting by unified bus in the sheet, its basic structure is the structure composition that adds peripheral chip by central processing unit CPu.This is the new trend of computer application system development for over ten years, compare with general CPu application system, its hardware generalization, measure that control ability is strong, volume is little, execution speed is fast, reliability is high, capacity of resisting disturbance is strong, applying flexible, easy to use, therefore to select single chip microcomputer for use be best to this device internal data system, its volume is little, and is multiple functional, can work alone as main frame separately, can become portable instrument, use very convenient.The internal data system of this device again can with the online use of external data processing system, be convenient to handle afterwards and constitute specialist system.
Referring to Fig. 4, be the circuit diagram of an amplifier in the analog signal instrumentation, it links to each other with electrode by fan-in network, and output is connected to wave filter, and several active electrodes are arranged, and several amplifiers are just arranged, and output walks abreast.
Amplification appliance adopts the high-acruracy survey amplifier, input+the IN of measuring amplifier and-IN is respectively two operational amplifier (A1, A2) in-phase input end, therefore input impedance is very high, adopt symmetrical structure, and measured signal directly is added to input, thereby guaranteed the ability of stronger inhibition common-mode signal, and it has the characteristics of low maladjustment voltage, low drift, highly sensitive, high stable simultaneously.
Referring to Fig. 5, it is the filter circuit on the analog signal instrumentation, the output signal of its reception amplifier, for anti-interference, select secondary filtering for use, its output signal is imported microcomputer through level conversion, the diagram step low-pass active filter, according to the passband of the gastrointestinal signal of telecommunication, use formula counting circuit parameter:
Passband 0.03-the 0.1Hz of stomach electricity,
Passband 0.03-the 0.2Hz of intestinal electricity,
For suppressing to disturb, passband can not be wide, but for passband useful signal is not in addition lost, (signal in 0.01-0.3Hz) does not end wave filter to the spectrum analysis scope, frequency component passband is outer with automatic spectral analysis technology also shows, and causes operator's attention.
Computing formula is as follows: cut-off frequency J = 1 2 π R 1 R 2 C 1 C 2 Quality factor Q = 1 R 2 C 2 R 1 C 1 + R 1 C 2 R 2 C 1 - r 2 r 1 R 1 C 1 R 2 C 2
Referring to Fig. 6, the sketch map that links to each other for ear electrode, external electrode, limb electrode and the box that leads.
Silver-silver chloride electrode is made of the silver chloride porous layer on fine silver and surface thereof, the electrode pair chloride ion is reversible, electrode is immersed the solution that contains chloride ion, when it during as anode, chloride ion just synthesizes AgCl with patina, when it during as negative electrode, chloride ion enters solution from the AgCl layer, AgCl is consumed, when reaching balance, the contiguous electric charge that takes place of metal-solution interface distributes again, sets up an equilibrated potential difference between metal and the electrolyte, at the vicinity of the metal-solution interface charged region that has living space.
Theory according to the Heimholtz proposition, the space-charge region is made of two zones of opposite charge, and one of them zone is in the metal surface, another zone, just in solution, stern has developed the notion of Heimholtrz and some other scholar extraction, and he proposes: in electrolyte, the space-charge region comprises two-layer, one deck is the electric charge close bed, the ion of being pressed close to the interface by amount is formed, and another layer is a diffusion layer, and it extends to place far away, interface.
In the space-charge region, potential difference is arranged, flowing of electronics just arranged, each electrode forms an interface between ionic conduction system and electronic conduction system, can think electrode one dielectric interface take place from the conversion of ionic conduction to electronic conduction, be a kind of power conversion, thereby think that bioelectrode plays transducer.The essential tool of surveying 2 potential differences of physiological system is a pair of electrodes, to form the loop.
Because the gastrointestinal signal of telecommunication is very weak, it is the microvolt magnitude, signal frequency is near direct current, many moving signal frequencies, amplitude are in the range of signal of stomach electricity, therefore anti-interference test is very important, removes and utilizes circuit filtering, beyond the digital filtering, each link of paying attention to testing also will have experimenter's cooperation.Understand the test philosophy of electrode, pay attention to the effect of chloride ion, electrode is selected concave structure for use, places saline cotton balls or sodium chloride conductive paste at concave surface during test, require the polarization deviation current potential of pair of electrodes little, and long-time stability is good.
Referring to Fig. 7, Fig. 7 A is normal clectrogastrogram, the normal and basic normal people of stomach function, the each several part coordination exercise waveform of stomach and spectrum distribution rule.Fig. 7 B is normal electrocolonogram, a kind of motion of colon is some independent contractions, be segmental, seldom advance, it will eat elk and Digestive system fully mixes, this is irregular activity, and intestinal wall fine hair is also wriggled because of the irregular contraction of muscular layer of mucosa, so the motion difference of colon each several part, it seems that waveform be rambling, frequency component is abundant, and normal person's colon electrical waveform is that size is mixed, the speed combination, and some negative carriers are arranged, wave amplitude, the rhythm and pace of moving things differ, irregular on the time distributes, but through the Fourier spectrum analysis, parameter has clear regularity.
The right side of figure is an oscillogram, and it represents the variation of signal intuitively, can sum up characteristic wave.The left side is a spectrogram, and the relation of expression power level and frequency comes into plain view the gastrointestinal electricity frequency that is difficult to analyze.
Can mainly contain two kinds from the pipe smooth muscle current potential that body surface records, first kind is spontaneous rhythm and pace of moving things current potential, the about 3CPm of frequency (inferior/minute), no matter whether stomach shrinks, it is constant existence, it has many titles, as slow wave (Slow Wave), basic electrical rhythm (Basic electric rhythum), electric control activity ECA (electric control activity), second kind of current potential is different from first kind, it always combines with activity such as contraction, and different researcheres have different names, as spike potential (Spike poteatial), the electric response activity ERA of fast wave (Fast activity) (electric response activi-ty) etc., the electrical activity of stomach comprise the slow complete automatic ripple that occurs mutually and are superimposed upon fast wave on the slow wave.
Gastrointestinal motility is by smooth muscle, nerve and the decision of hormone effect composite factor.The test gastrointestinal signal of telecommunication will solve Detection of Weak Signals and signal analysis two hang-ups.During analytic signal, note amplitude, its variation is conspicuous, but analysis frequency index difficulty.The gastrointestinal electricity is the same with other bioelectrical signals, is stochastic signal, can not predict, can not describe by a definite mathematical formulae.Average simply and can not represent the real case of signal.The present invention analyzes the gastrointestinal signal of telecommunication with relevant and spectrum, obtains the actual frequency of signal with the Fourier spectrum analysis.The relation of typical frequency analysis figure display frequency and power level, it comes into plain view the gastrointestinal electricity frequency that is difficult to analyze.For example normal clectrogastrogram, show peak power in the 3CPm frequency, and other frequency has only very little power, a not too regular clectrogastrogram, on power spectrum, show as the distribute power of wide scope, so spectrum analysis not only provides frequency but also shown amplitude information.
The gastrointestinal motility rule mainly shows on the frequency numerical value, select analytical parameters to want the feature of reflected signal, the stomach electricity is called crest frequency FP or is called dominant frequency, fundamental frequency through the frequency values of the power spectrum maximum that spectrum analysis obtains, power spectrum function is asked first moment, draw mid frequency FC, it is the center of gravity of power spectrum on frequency axis, statistically represent the frequency distribution deviation, the average time of signal zero passage in the unit interval (meansigma methods that is actually with amplitude is zero), be called on average and cross zero frequency FV it can reflect fast wave, represent electric response activity ERA.
Fourier spectrum analysis formulate is as follows: P ( W ) = ∫ - ∝ ∝ f ( t ) exp ( - fwt ) dt
In the formula: W=2 π f
F (t) is the time domain expression formula of signal
P (W) power spectrum function, the signal frequency-domain expression formula
Display parameters among the figure are:
1. the numeral electrode number of delegation topmost.
2.A PThe average peak amplitude: each peak value to the gastrointestinal electric signal waveform is averaged, and unit is μ V.
3.F ZThe average zero frequency of crossing: the number of times of statistics waveform zero passage (is zero point with the average amplitude) is one-period with twice zero passage, and again divided by Measuring Time, unit is inferior/minute (CPm).
4.F C, mid frequency: the power spectrum function P (f) to signal asks first moment, by formula obtains then:
Figure C9310231800081
5.F PCrest frequency: i.e. the frequency values at the maximum place in power spectrum place, unit is cpm.
6. two digital multiplying powers are arranged under the spectrogram, are the power levels that is used for calculating each frequency component, and formula is as follows: P ( J 2 ) = H × 15 × 2 π - n ( μV ) 2
In the formula: P (f 0) be the power level of a certain frequency component.
M is a multiplying power
H is f=f 0Point spectral line high millimeter, available ruler are directly measured in spectrogram, the about 0.8mm of width of each frequency component (spectral line) in the drawings, and general power is in the power sum of each spectral line.
Referring to Fig. 8 is the sketch map of operation collection of illustrative plates.
Change for studying the gastral time, necessary long-time continuous detection signal, the Fourier spectrum analysis provides traditionally only is the function of frequency but not time function, the operation analysis of spectrum be will obtain part repeat data rated output spectrum and open up and be time function, with new technique frequency, power, time are described as false three-dimensional the expansion.For example surveyed 2 hours continuously, divide 18 sections, each section 6 minutes and 40 seconds, during the service chart analysis of spectrum, realize gathering automatically, analyze automatically, automatically record, whole oscillograms is pressed the section demonstration, according to the spectrogram synchronous expansion of the waveform transformation of each section, like this with T 1, T 2, T 3... T 18Continuous record, just showed spectrogram over time, therefore the medicated cap of shaking, frequency, the unfolded connotation of false three-dimensional of time are arranged, this is that the present invention is the time dependent characteristic in expression gastro-intestinal digestion road, the new technique of proposition.If the operator observes a period of time, seen that experimenter's signal rule has repeatability, can artificially control the testing time, after first section, the 18 section tested in former any time, the operator can press once " service chart, spectrum " key again, ends continuous operation, prints every recording parameters A then under figure P, E P, F C, F Z, be exactly to survey three times operation collection of illustrative plates and parameter continuously as Fig. 8.
Referring to Fig. 9 is to compose the sketch map of composing with normalizing automatically.
The normalizing spectrum is that each road signal shows power spectrum by same yardstick, in same section test, by maximum intensity calibration, the spectrogram of other signal is just unintelligible, and shown in Fig. 9 (a), Fig. 9 (b) amplifies spectrum component with automatic spectral analysis technology, each road signal all is the component calibration with the power spectrum maximum, therefore figure amplifies, and frequency spectrum multiplying power m value reduces, and makes all spectrograms of energy clear display of very strong and very weak signal like this.
Referring to Figure 10 is the workflow diagram of gastrointestinal electrical signal detection blood processor of the present invention
At first in step 120, when starting this device, want initialization, each work register zero clearing to computer processor, programmable input/output port is put the working method word, to the intervalometer constant etc. of fixing time, the duty of step 121 read apparatus, whether the each several part work of judgment means is normal, whether data recording equipment is online, select several passage work, how many gains of each passage is, be to survey stomach or survey intestinal, be automatic spectrum or normalizing spectrum or the like, if it is all normal, monitor that " P " appears in indication,, do not enter monitor state if having undesiredly, " E " appears in the work indication, the operator will in time handle, and make the device operate as normal, enter monitor state.Step 122 is to judge to have or not new data, if new data are arranged, also to 123 judge whether set by step in communication, for communication data is not lost, after communication, set by step 124, new data is sent into internal memory replace old data, then set by step 125, carry out date processing, be exactly data smoothing, 4096 points of each section every road sample of signal, get one smoothing method with four, take out 1024 data, 126 carry out Fourier spectrum transformation set by step, frequency resolution reaches 0.0025Hz, 127 compose automatically or normalizing spectrum display process set by step again, get the key assignments unit then set by step, successively function keyboard is scanned.If acquired signal; press " measurement " key according to step 129; set up the collection sign in step 130; at this moment, " C " appears in the work indication on the panel, and program enters the collection subprogram; as shown in figure 11; in bright 6 minutes and 40 seconds of collection sign " C ", gather and carry out, by intervalometer decision sample rate with interrupt mode; set by step 1304; 1305 start multichannel analog digital conversion image data; connect step 1306 then; 1307 keyboard scans are sent image data into buffer register more successively, and 1308 recoveries are on-the-spot set by step then; data protection is got up; in order to avoid lose, return information needs only acquisition time and does not arrive then; just interrupt gathering and regularly carry out; every collection is intact once just to enter mastery routine, enters subprogram again to timing acquisition time.A plurality of like this electrode detection to the gastrointestinal signal of telecommunication enter microcomputer through amplification; carry out synchronized sampling with a fixed frequency, carry out, so checkout gear is in the intermittent time of acquired signal with interrupt mode; can draw simultaneously and date processing; after collection is finished, if this moment, drawing work was still carried out, in order to protect the data of having gathered; during programming; it is at this moment invalid by gathering key to allow, and forbids new collection, up to the drawing end-of-job; new data are by safe transfer; it is effective again to gather key, allows and carries out new collection, and this moment is again by the drawing key; the new data that just shifts into is just through step 125; 126,127 handle, and can draw out.Execution in step 131, by the drawing key, just 132 enter the drawing subprogram set by step, as shown in figure 12, print coordinate axes successively, paint oscillogram earlier, print parameters, paint spectrogram again, because be multiple channel test, paint figure, the parameter of one road signal each time, treat that whole figure have painted, print the DC component of each passage, 1327 return mastery routine set by step at last.
When needing continuous measurement, press " service chart, spectrum " key, just enter the subprogram of service chart, spectrum, as shown in figure 13 according to step 134 according to the step 133 of mastery routine.At first press the step 134 of subprogram, set up sign, on left side work indication charactron, show " Y ", carry out subregion collection to signal this moment, each section 6 minutes and 40 seconds, gather and finish, enter step 1343, new data enter internal memory, replace old data, 1345 carry out date processing set by step again, 1346 carry out Fourier spectrum transformation set by step, 1347 set up communication mark " S " set by step again, send data to outside data handling system, the entry communication subprogram, as shown in figure 14, communication is to control by byte number, byte to be transmitted counts up to, press subroutine procedure 1380 and eliminate communication mark " S ", recover on-the-spot, 1382 return operation music score program set by step (not at service chart, during the spectrum duty, press receipts with mastery routine step 135, when sending out key, transmit and to return mastery routine when byte counts up to), then according to Figure 13 in program the 1348th step, paint oscillogram, spectrogram, this all is by programme-control, automatically perform, can end to measure, set by step 1349 if the operator thinks, once more by same " service chart; spectrum " key, but cease operation just, set by step 1351,1352 print parameters, 1353 monitor states that return mastery routine set by step.Be good for if do not press " service chart, spectrum " once more,, judge whether two hours continuous acquisition is finished, continue 2 hours, automatic collection, automatic analysis, communication automatically, automatic record always just according to subroutine procedure 1350.
Referring to Figure 15 is the panel appearance figure of gastrointestinal electrical signal detection blood processor of the present invention, and output recording equipment, detection ammeter, gauge tap, function keyboard, the digital demonstration are all represented in the above.
Comprehensively above-mentioned, the present invention has increased the intestinal measurement on the basis of utility model patent 89208706.4, use assembler language, and counting from 512 of fourier transform is increased to 1024 points, makes frequency resolution reach 0.0025Hz, has improved the precision of analyzing.Use automatic spectral analysis technology, make all frequency spectrum images of energy clear display of very strong and very weak signal.The present invention proposes new technique for studying the gastro-intestinal digestion road over time, adopts the mode of service chart, spectrum, signal is carried out zone detection, and divide sectional analysis and record, oscillogram is shown according to section, the frequency spectrum synchronous expansion that obtains according to each section waveform transformation is like this with T 1, T 2, T 3... T 18Follow-on test, record, just represented frequency spectrum over time, amplitude, frequency, time are described as false three-dimensional the expansion, be convenient to the frequency spectrum that bus goes out signature waveform, be used to diagnose the illness.Simultaneously, be the electric control activity and the electric response activity of expression stomach, intestinal, the present invention brings up to quantitative analysis in conjunction with clinical practice from qualitative analysis, proposes the series of analysis parameter: crest frequency F P, mid frequency F C, the average zero frequency F that crosses Z, the average peak amplitude A PDeng, this is creation of the present invention, and confirms that by practice this is of great value.The present invention also proposes new method of testing and uses multiple electrode, is different from other bio-electrical test.Adopt a plurality of silver-silver chloride electrodes; An ear electrode is placed on and irrelevant ear-lobe or the mastoid process in tested position, as effective reference electrode, and a limb electrode, as the safety ground electrode, a plurality of external electrodes, as effective detecting electrode, such method good in anti-interference performance.The invention solves the difficult problem of the long-time steady testing gastrointestinal signal of telecommunication, clinical practice is pushed forward.Simultaneously, the present invention adopts the structure of inside, external data processing system, and the internal host that function is strong can work independently, again can with the online use of outer computer, be convenient to handle and constitute specialist system afterwards, satisfy the customer requirements of different levels, be beneficial to the popularization of instrument.
Gastrointestinal disease is commonly encountered diseases, frequently-occurring disease, endoscope, image check not only have misery, and can't diagnose the stomach and intestine dynamics disease, gastrointestinal electrical signal detection blood processor of the present invention provides no pain AT inspection means, meet the development trend that reason detects for medical science, the present invention has broad application prospects.

Claims (2)

1. gastrointestinal electrical signal detection blood processor, comprise a plurality of detecting electrodes, an analog signal instrumentation, a digital signal device, a data recording equipment, an ammeter monitoring arrangement, a switch controlling device, a supply unit, it is characterized in that all electrodes all adopt the silver-silver chloride electrode of concave surface, comprising:
An ear electrode-public reference electrode;
A limb electrode-ground electrode;
A plurality of external electrode-active electrodes;
The a plurality of electrodes of box that leads-connect.
2. the method that the gastrointestinal electro-detection is handled comprises: detect by the signal of a plurality of detecting electrodes to gastrointestinal electricity different parts; By a multichannel amplification, filter circuit to detected signal amplify and and line output; Sample circuit improves the synchronized sampling frequency, and analog digital conversion is converted to the multi-path digital signal with multichannel analog signals; Deposit sampled data in buffer register; Signal processing apparatus takes out sampled data from the buffering depositor, the filtering of advanced line number word is level and smooth, carries out time domain, frequency domain processing then, to obtain corresponding time domain, frequency curve and calculating parameter; By " drawing key ", output device is with above-mentioned curve and supplemental characteristic output, by recording device records, it is characterized in that, also comprise electrode and method of testing: select spill silver-silver chloride electrode for use, adopt the one pole method of testing, promptly an active electrode and a reference electrode form a loop, when the present invention tests with an ear electrode as public reference electrode, select for use and the irrelevant ear-lobe in tested position or the position of mastoid process, a limb electrode ground connection, other many external electrodes are as the Validity Test electrode, and such method of testing overcomes the effective of artifacts.
CN 93102318 1993-03-04 1993-03-04 Gastrointestinal electric signal detection processing device and method Expired - Fee Related CN1047512C (en)

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CN102374255A (en) * 2010-08-05 2012-03-14 香港中文大学 Self-powered and self-sensing magnetorheological (MR) fluid damper
CN108392196A (en) * 2018-04-13 2018-08-14 南京宽诚科技有限公司 A kind of transmission method, device and the photoisolator of stomach and intestine electric signal

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SE9403344L (en) * 1994-09-30 1996-03-31 Synectics Medical Ab Procedure and apparatus for mainly electrogastrography and electrourography
CN101363841B (en) * 2007-08-09 2013-06-12 理康互联科技(北京)有限公司 Physiology situation information acquisition device
CN108567423A (en) * 2018-03-07 2018-09-25 南京宽诚科技有限公司 A kind of detection method and device of bioelectrical signals
CN108742590A (en) * 2018-04-08 2018-11-06 南京宽诚科技有限公司 A kind of acquisition method, device, collecting device and the storage medium of stomach and intestine electric signal
CN108634948A (en) * 2018-05-11 2018-10-12 南京宽诚科技有限公司 A kind of detection method, device, detection device and the storage medium of stomach and intestine electric signal
CN110279410A (en) * 2019-06-26 2019-09-27 天津大学 Portable minisize is wireless stomach electricity collector

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102374255A (en) * 2010-08-05 2012-03-14 香港中文大学 Self-powered and self-sensing magnetorheological (MR) fluid damper
CN108392196A (en) * 2018-04-13 2018-08-14 南京宽诚科技有限公司 A kind of transmission method, device and the photoisolator of stomach and intestine electric signal

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