CN104740332A - 一种治疗结节性红斑的中药 - Google Patents
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Abstract
本发明涉及治疗结节性红斑的药物，尤其是一种以植物中草药为原料制成的治疗结节性红斑的中药。其特征在于：其中药原料及重量配比为：茵陈5-10克，苍术10-15克，威灵仙10-15克，川芎13-19克，当归13-19克，山甲珠13-19克，麦冬13-19克，石斛13-19克，山慈姑3-9克，瓜蒌10-15克，甘草3-9克。本发明中药的各组分均采用天然的中药原料，其配置简单，药源广、成本低。该中药药效协同作用，具有清热解毒，清化湿热，清化痰结，消肿散结，理气和血，通络止痛等功效，对治疗湿热毒聚皮肤血络引起的结节性红斑有显著效果。
Description
技术领域
本发明涉及治疗结节性红斑的药物，尤其是一种以植物中草药为原料制成的治疗结节性红斑的中药。
背景技术
结节性红斑是一种累及真皮血管和脂膜组织的反应性炎性疾病，常位小腿胫前部皮肤呈红色或紫红色类性结节改变。一般认为与感染，尤其是链球菌感染和药物反应有关。结核病亦是重要的诱发因素，特别是儿童。此外，病毒、真菌等感染，溴化物、碘化物、磺胺等药物亦可诱发本病。结节性红斑结节性红斑常发生在四肢的伸侧，尤其多见于小腿的伸侧，突然急性发病，先发热达39℃以上，可有抽痛，关节酸痛及全身不适，继之成批出现数量较多的鲜红色结节，圆形或椭圆形，直径约2-5cm，稍高出皮肤，皮肤表面光滑，有时发亮，有疼痛及压痛。一般在小腿伸侧，也可累及四肢、臀部等处，大都在3-6周左右结节由硬变软，颜色由鲜红转为蓝红色，青黑色，最后带褐色色素沉着，不破溃而消失。血沉增快，白细胞增高，蛋白电泳显示α2及γ球蛋白增高；中医认为本病是由于湿热内盛，阻滞筋脉，导致气滞血瘀。结节性红斑中医称之为“瓜藤缠”，从中医辩证来讲其病机病因为湿邪粘腻停滞，郁久化热，湿热蕴结于肌腠脉络，湿热下注，气滞血瘀，经络阻塞，顽湿聚结而发病；或饮食不节，脾虚湿盛，气血运行不畅，再加外感风寒湿邪，寒凝血脉形成气滞血瘀，经络阻塞而发病。脾喜燥恶湿，主运化水谷精微统摄血液，为气、血、精、津液生化之源被称为后天之本。目前本病主要是只有依赖于抗生素和糖皮质激素控制病情，不能得到彻底的治愈，必须借助于中医药来根治结节性红斑。因此本发明特进一步优选采用了一种治疗结节性红斑的中药。
发明内容
为了克服现有技术治疗结节性红斑存在的不足,本发明提供了一种配制方便、药源广、成本低、疗效显著、作用可靠的治疗结节性红斑的中药。
本发明解决其技术问题所采用的技术方案是：一种治疗结节性红斑的中药，其特征在于：其中药原料及重量配比为：茵陈5-10克，苍术10-15克，威灵仙10-15克，川芎13-19克，当归13-19克，山甲珠13-19克，麦冬13-19克，石斛13-19克，山慈姑3-9克，瓜蒌10-15克，甘草3-9克。
用法：一天一剂，水煎服，分三次服用。7天为一个疗程。
本发明的优选技术方案是：一种治疗结节性红斑的中药，其特征在于：其中药原料及重量配比为：茵陈8克，苍术13克，威灵仙13克，川芎16克，当归16克，山甲珠16克，麦冬16克，石斛16克，山慈姑6克，瓜蒌13克，甘草6克。
药理作用
茵陈：清湿热，退黄疸。用于黄疸尿少、湿疮瘙痒、传染性黄疸型肝炎。
苍术：燥湿健脾，祛风散寒，明目。用于脘腹胀满，泄泻水肿，脚气痿躄，风湿痹痛，风寒感冒，夜盲。
威灵仙：具有祛风除湿，通络止痛，消痰散积功效。主治风寒湿痹，腰膝冷痛，肢体麻木，筋骨脉动拘挛，脚气肿痛，胸膈痰饮，腹内冷积，诸骨鲠咽。
川芎：活血祛瘀，祛风止痛的功效，治月经不调、经闭、痛经，头风头痛，风湿痹痛，症瘕结块，疮疡肿痛、跌打损伤。
当归：补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。
山甲珠：通经下乳，消肿排脓，搜风通络。用于经闭癓瘕，乳汁不通，痈肿疮毒，关节痹痛，麻木拘挛。
麦冬：具有养阴生津，润肺清心的功效，用于肺燥干咳，虚痨咳嗽，津伤口渴，心烦失眠，内热消渴，肠燥便秘等症。
石斛：益胃生津，滋阴清热。用于热伤津液，低热烦渴，舌红少苔；胃阴不足，口渴咽干，呕逆少食，胃脘隐痛，舌光少苔；肾阴不足，视物昏花。
山慈姑：散结，化瘀。治咽喉肿痛，瘰疬，痈疽，疮肿，产后瘀滞。
瓜蒌：清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。
甘草：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
本发明的有益效果是， 本发明中药的各组分均采用天然的中药
原料，其配置简单，药源广、成本低。该中药药效协同作用，具有清热解毒，清化湿热，清化痰结，消肿散结，理气和血，通络止痛等功效，对治疗湿热毒聚皮肤血络引起的结节性红斑有显著效果。
下面结合临床实验数据说明本发明的有益效果：
临床资料
发明人2010年6月到2011年9月间共收集结节性红斑的门诊及住院病人58例，男18例，女40例，年龄18-35岁。随机分成两组，其中治疗组29例，男8例，女21例；年龄18-34岁，病程3天到30天，对照组29例，男10例，女19例，年龄18-35岁之间；病程2天到30天，两组性别、年龄等资料无显著性差异（P>0.05），具有可比性。
治疗方法
治疗组 采用本发明治疗结节性红斑的中药，水煎服，每日一剂，每日三次。
对照组 口服非激素类抗炎剂消炎痛25 mg,维生素C片0.2g，芦丁片2 片，一天3次。
疗程均为7天一个疗程。至少治疗四个疗程。
疗效标准
参照《中医病证诊断疗效标准》评价疗效。痊愈：全身症状消失，皮损消退；显效：全身症状明显好转，皮损消退70%-94%；好转：全身症状已控制，无新疹出现，皮损消退30%-69%；无效：全身症状未减轻，仍有新疹出现。
治疗效果
治疗统计结果见表1
表1两组疗效比较
| 组别 | 病例数 | 痊愈 | 显效 | 好转 | 无效 | 总有效率（%） |
| 治疗组 | 29 | 16 | 10 | 3 | 2 | 93.1 |
| 对照组 | 29 | 10 | 7 | 5 | 7 | 75.9 |
临床观察表明，本发明对治疗结节性红斑具有很好的疗效，优势明显，且本发明中药价格低廉，无毒副作用。
典型病例
黄某某，女，22岁，患者出现发烧，咽部不适，头痛口渴，双膝、踝关节疼痛，同时发现双小腿胫前有数个散在小疙瘩，色红，有压痛，经诊断为结节性红斑，西药治疗无好转，于是服用治疗结节性红斑的中药两个疗程后，症状减轻，继续服用两个疗程，痊愈，随访半年无复发。
房某某，女，20岁，小腿反复起红疙瘩,疼痛,初起时疼痛明显,活动后疼痛加剧,影响活动,有时有传电样麻酥感，经诊断为结节性红斑，西药治疗无好转，于是服用治疗结节性红斑的中药两个疗程后，症状减轻，继续服用两个疗程，痊愈，随访一年无复发。
具体实施方式
一种治疗结节性红斑的中药，其特征在于：其中药原料及重量配比为：茵陈8克，苍术13克，威灵仙13克，川芎16克，当归16克，山甲珠16克，麦冬16克，石斛16克，山慈姑6克，瓜蒌13克，甘草6克。先将药物用水洗净后，用冷水浸泡15-20分钟，然后将药物放在砂锅、陶瓷或者瓦罐之类的器皿里（不可以用铁锅和铝锅），加水至没过药面5厘米左右，进行第一次煎煮，用大火煮沸后，改用小火煎煮20-30分钟就好，将药汤倒在器皿里，再煎第二遍，煎煮第二遍的方法同第一遍一样，只是煮沸后用小火煎煮15-20分钟即可。煎完以后，两次煎煮去渣取汁，合并后服用。
Claims (2)
1. 一种治疗结节性红斑的中药，其特征在于：其中药原料及重量配比为：茵陈5-10克，苍术10-15克，威灵仙10-15克，川芎13-19克，当归13-19克，山甲珠13-19克，麦冬13-19克，石斛13-19克，山慈姑3-9克，瓜蒌10-15克，甘草3-9克。
2.根据权利要求1所述治疗结节性红斑的中药，其特征在于：其中药原料及重量配比为：茵陈8克，苍术13克，威灵仙13克，川芎16克，当归16克，山甲珠16克，麦冬16克，石斛16克，山慈姑6克，瓜蒌13克，甘草6克。
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| CN105853731A (zh) * | 2016-04-20 | 2016-08-17 | 陈程辉 | 一种用于治疗结节性红斑的药物 |
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| CN105853731A (zh) * | 2016-04-20 | 2016-08-17 | 陈程辉 | 一种用于治疗结节性红斑的药物 |
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