CN104740119A - Blood circulation-activating externally-applying bone joining ointment capable of promoting injured bone healing and preparation method thereof - Google Patents
Blood circulation-activating externally-applying bone joining ointment capable of promoting injured bone healing and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a blood circulation-activating externally-applying bone joining ointment capable of promoting injured bone healing. The blood circulation-activating externally-applying bone joining ointment is characterized by being prepared from the following main raw materials in parts by weight: 10-20 parts of semen litchi, 10-25 parts of salvia miltiorrhiza, 5-15 parts of dipsacus root, 15-25 parts of myrrh, 3-8 parts of momordica cochinchinensis, 12-24 parts of frankincense, 20-30 parts of pericarpium citri reticulatae viride, 20-40 parts of japanese thirstle root, 13-27 parts of rhizoma drynariae, 4-17 parts of beautiful sweetgum fruit, 25-35 parts of ligusticum wallichii, 4-10 parts of concha arcae, 20-35 parts of astragalus membranaceus, 15-20 parts of latifolious rush rhizome and 10-20 parts of honeysuckle. The blood circulation-activating externally-applying bone joining ointment is remarkable in effects on bone injuries, and capable of activating blood circulation and removing stasis, relaxing muscles and stimulating blood circulation, conditioning qi and blood, and improving the long-time pain of patients brought by bone injuries; moreover, local common medicinal materials are mainly used, and the prices are low, thus reducing the financial burdens of the patients.
Description
Technical field
The invention discloses one to invigorate blood circulation external application JIEGU GAO, especially a kind of external application JIEGU GAO and preparation method thereof of invigorating blood circulation promoting the injury of the bone to heal, the invention belongs to traditional Chinese medicine field.
Background technology
In Traditional Chinese Medicine, bone injury is a more wide in range concept, comprise the diseases such as fracture, joint dislocation, the injury of tendon and muscle, bone injury, periosteum injury, also comprise the diseases such as hyperosteogeny, scapulohumeral periarthritis, cervical spondylosis, prolapse of lumbar intervertebral disc, rheumatic arthritis, to these diseases, the Therapeutic Method of doctor trained in Western medicine is generally oral drugs or is aided with physical therapy, massage etc., and its effect also just controls symptom development, and be difficult to radical cure, and oral western medicine also has certain toxic and side effects.
In the method for existing promotion bone injury healing, the medicine that patent discloses a kind of set a broken bone of Authorization Notice No. CN 101933999 B (application number 200910065367.0), is characterized in that being prepared from by the raw material of following weight parts: Radix Codonopsis 10-15, Poria 10-15, Fructus Lycii 10-15, Rhizoma Atractylodis Macrocephalae 8-12, Radix Salviae Miltiorrhizae 15-20, Fructus Chaenomelis 8-12, Radix Achyranthis Bidentatae 10-15, Radix Angelicae Sinensis 8-12, Olibanum 5-10.The medicine that patent discloses a kind of set a broken bone of Authorization Notice No. CN 102526328 B (application number 201210039216.X), it is characterized in that, each raw material is by following weight proportion composition: major ingredient: Radix Angelicae Sinensis 5-10 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Linderae 10-15 part, Caulis Lonicerae 15-30 part, Radix Rehmanniae Preparata 12-15 part, Rhizoma Polygoni Cuspidati 5-10 part, Flos Lonicerae 8-10 part, Ramulus Sambuci Williamsii 6-10 part, Fructus Liquidambaris 15-20 part, Rhizoma Drynariae 11-15 part, Cortex Eucommiae 5-10 part, Radix Dipsaci 5-10 part, Semen Strychni 5-8 part, Ramulus Cinnamomi 9-13 part, Rhizoma Et Radix Notopterygii 10-15 part, Rhizoma Atractylodis 5-10 part, Fructus Liquidambaris 15-20 part, Rhizoma Chuanxiong 15-20 part, Caulis Spatholobi 8-10 part, Olibanum 10-15 part, Radix Glycyrrhizae 7-10 part, Scorpio 10-15 part, Radix Angelicae Dahuricae 5-10 part, Radix Paeoniae Rubra 8-10 part, Cornu Cervi Pantotrichum 4-8 part, Moschus 3-5 part
Chinese medicine occupies very consequence in promotion bone injury healing as can be seen here, but its main dosage form of existing patent is decoction, for promoting the effect of bone injury healing and not as compositions ideal, can causing extra burden to the health of patient.
Summary of the invention
For the present situation of existing promotion bone injury healing deficiency, an object of the present invention is to provide a kind of external application JIEGU GAO of invigorating blood circulation promoting the injury of the bone to heal, have easy to carry, action effect is obvious, can be very fast play blood circulation promoting and blood stasis dispelling, effect that granulation promoting is good for bone, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The external application JIEGU GAO of invigorating blood circulation promoting the injury of the bone to heal, takes off the primary raw material stating weight proportion and is prepared from: Semen Litchi 10-20 part, Radix Salviae Miltiorrhizae 10-25 part, Radix Dipsaci 5-15 part, Myrrha 15-25 part, Semen Momordicae 3-8 part, Olibanum 12-24 part, Pericarpium Citri Reticulatae Viride 20-30 part, cirsii japonici,radix 20-40 part, Rhizoma Drynariae 13-27 part, Fructus Liquidambaris 4-17 part, Rhizoma Chuanxiong 25-35 part, Concha Arcae 4-10 part, Radix Astragali 20-35 part, Juncus amplifolius A. Camus 15-20 part, Flos Lonicerae 10-20 part.
The external application JIEGU GAO of invigorating blood circulation promoting the injury of the bone to heal, optimum ratio, takes off the primary raw material stating weight proportion and is prepared from: Semen Litchi 13-18 part, Radix Salviae Miltiorrhizae 14-20 part, Radix Dipsaci 8-13 part, Myrrha 18-23 part, Semen Momordicae 4-6 part, Olibanum 16-20 part, Pericarpium Citri Reticulatae Viride 23-28 part, cirsii japonici,radix 25-35 part, Rhizoma Drynariae 15-25 part, Fructus Liquidambaris 7-10 part, Rhizoma Chuanxiong 28-33 part, Concha Arcae 6-8 part, Radix Astragali 28-33 part, Juncus amplifolius A. Camus 16-19 part, Flos Lonicerae 13-18 part.
The external application JIEGU GAO of invigorating blood circulation promoting the injury of the bone to heal, better preferred proportioning, takes off the primary raw material stating weight proportion and is prepared from: Semen Litchi 15 parts, Radix Salviae Miltiorrhizae 17 parts, Radix Dipsaci 10 parts, Myrrha 20 parts, Semen Momordicae 5 parts, Olibanum 18 parts, 25 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 30 parts, Rhizoma Drynariae 20 parts, Fructus Liquidambaris 9 parts, Rhizoma Chuanxiong 30 parts, Concha Arcae 7 parts, the Radix Astragali 30 parts, Juncus amplifolius A. Camus 17 parts, Flos Lonicerae 15 parts.
The preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation, preparation process is as follows:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 80-120 mesh sieve stand-by;
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 10-20 minute, fries 3-8 minute with slow fire, dries in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 2-6 days, be placed in non iron container, add raw material gross weight 2-4 Chinese liquor doubly, soak 2-8 hour, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 80-120 mesh sieve for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, first time adds raw material gross weight 1-3 water doubly, intense fire is fried open, and turns slow fire boiling 10-15 minute, and ceaselessly stirs, filter, obtain filtrate 1, second time adds raw material gross weight 0.5-1.5 water doubly, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 60-70 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
Above-mentioned preparation method, step (1) smalls crosses 90-110 mesh sieve stand-by (preferred, it is stand-by that smalls crosses 100 mesh sieves).
Above-mentioned preparation method, the slightly stewing 13-18 minute of step (2), fries 4-7 minute (preferred, slightly stewing 15 minutes, to fry 6 minutes with slow fire) with slow fire.
Above-mentioned preparation method, step (3) is by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 3-5 days (preferred, by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 4 days).
Above-mentioned preparation method, step (3) adds Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae weight 2.5-3.5 Chinese liquor doubly (preferred, to add the Chinese liquor of Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae weight 3 times).
Above-mentioned preparation method, step (4) first time adds raw material gross weight 1.5-2.5 water doubly, and intense fire is fried open, it is (preferred to turn slow fire boiling 11-14 minute, add the water of raw material gross weight 2 times for the first time, intense fire is fried open, and turns slow fire boiling 13 minutes).
Above-mentioned preparation method, step (5) little fire is decocted slowly to 63-68 DEG C, adds Cera Flava (preferred, little fire is decocted slowly to 65 DEG C, adds Cera Flava).
Using method: for making the present invention reach optimum therapeuticing effect, gets external application JIEGU GAO 10g and spreads upon bone injury position, within 1 day, changes once, within 10 days, is a course for the treatment of.
This external application JIEGU GAO Be very effective to bone injury of invigorating blood circulation, not only blood circulation promoting and blood stasis dispelling, can also relaxing muscles and tendons to promote blood circulation, and QI and blood regulating, improves patient for a long time because of the slight illness that bone injury is brought, and the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
The external application JIEGU GAO of invigorating blood circulation promoting the injury of the bone to heal, the pharmacological effect of each crude drug is respectively:
Semen Litchi: sweet, micro-hardship, temperature.Return liver, kidney channel.Promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.For colic of cold type stomachache, painful and swollen testis.
Radix Salviae Miltiorrhizae: have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
Radix Dipsaci: invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.Control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer swells.
Myrrha: cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.Be in the Orient a kind ofly to invigorate blood circulation, blood stasis dispelling, pain relieving, stomach invigorating Chinese medicine.
Semen Momordicae: base is former: be the seed of Cucurbitaceae Momordica plant wood nose.Composition: seed containing saponin: momordin I and II Semen Momordicae determine I and I c, albumen and peptide class: Semen Momordicae glycoprotein S, N-powder stamen Buxus sinica (Rehd.et Wils.) alcohol pentapeptide, momordic acid you, oleanolic acid, sterol, Cochinchinin etc.The property of medicine: bitter, micro-sweet, temperature, poisonous.Return liver, spleen, stomach warp.Function cures mainly: dispersing swelling and dissipating binds, chases after wind pain relieving.Cure mainly carbuncle, furuncle, innominate toxic swelling, hemorrhoid, acne, black dry once black, bone injury, tuberculous lymphadenitis, dysentery, rheumatic arthralgia, the contracture of muscle arteries and veins, gingival swelling and pain.
Olibanum: pungent, bitter, temperature, blood-activating and qi-promoting pain relieving, detumescence and promoting granulation, for obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.
Pericarpium Citri Reticulatae Viride: base is former: be Rutaceae mandarin tree plant Fructus Citri tangerinae and the young fruit of variety thereof or the peel of immature fruit.Composition: Pericarpium Citri Reticulatae Viride is containing boosting effective ingredient: left-handed Neosynephrine acetate; Also containing aspartic acid, glutamic acid, proline, glycine, alanine, cystine, leucine, isoleucine, phenylalanine etc.The property of medicine: bitter, pungent, temperature.Return liver, gallbladder, stomach warp.Function cures mainly: soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.Cure mainly the side of body rib, breast, epigastric distending pain, nodule in the breast, acute mastitis, hernia, food stagnation, lump in the abdomen, chronic malaria addiction block.
Cirsii japonici,radix: another name horse Ji, brave Ji, cat Ji, field thistle, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), field thistle dish etc.Flavor efficacy is sweet, bitter, the cooler profit of property.Merit arrogates to oneself removing heat from blood, hemostasis, is applicable to treat the multiple hemorrhage caused by bleeding due to blood-heat, as spitting of blood, epistaxis, metrorrhagia, hematuria etc.; Be longer than blood stasis dispelling again, subduing inflammation, granulation promoting evacuation of pus.Can be used for treatment hemorrhoidal hamorrhage acute appendicitis, pain infections toxic swelling, furuncle, scrofula tuberculosis etc.
Rhizoma Drynariae: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.The kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.
Fructus Liquidambaris: bitter is flat.Return liver, kidney channel, dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Rhizoma Chuanxiong: base is former: be the rhizome of Umbelliferae GAOMU platymiscium Rhizoma Chuanxiong.Composition: rhizome is containing multiple lactone: ligustrazine, loline or perlolyrine, GAOMU lactone, Rhizoma Chuanxiong naphthalene furan lactone, butylphthalide, two phthalide-type, cnidiumm lactone etc.The property of medicine: pungent, temperature.Return liver, gallbladder pericardium channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.Cure mainly menoxenia, amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen lump, pain in chest and hypochondrium, has a headache dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores.
Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, for Carnis Arca inflata section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter is hard, sweet in the mouth, salty, property is put down.Composition: main component is calcium carbonate, also containing a small amount of calcium phosphate and magnesium, ferrum, silicate.Find according to modern pharmacological research, this medical instrument has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.
The Radix Astragali: it has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.The Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc.
Juncus amplifolius A. Camus: base is former: for rush family sharp-flowered rush plant walks the rhizome of stem Medulla Junci.The property of medicine: property is put down, acrid in the mouth, micro-hardship.Function cures mainly: regulating QI to relieve pain, and regulating menstruation and activating blood cures mainly stagnation of QI due to depression of the liver, pain in chest and hypochondrium, menoxenia, metrorrhagia leukorrhagia.
Flos Lonicerae: Flos Lonicerae is just extensive and famous with its medical value since ancient times.Its effect mainly heat-clearing and toxic substances removing, cures mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle furunculosis etc.Modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.Sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute bone injury, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
The present invention's external application JIEGU GAO of invigorating blood circulation promotes the principle of bone injury healing based on Chinese medicine.The Chinese medicinal material selected all has blood circulation promoting and blood stasis dispelling, effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, and cheap, and life-time service also can not cause the financial burden of patient, is the medicine promoting that bone injury healing is ideal.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
External application JIEGU GAO that what embodiment 1 one kinds promoted the injury of the bone to heal invigorate blood circulation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Semen Litchi 10 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Dipsaci 5 parts, Myrrha 15 parts, Semen Momordicae 3 parts, Olibanum 12 parts, 20 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 20 parts, Rhizoma Drynariae 13 parts, Fructus Liquidambaris 4 parts, Rhizoma Chuanxiong 25 parts, Concha Arcae 4 parts, the Radix Astragali 20 parts, Juncus amplifolius A. Camus 15 parts, Flos Lonicerae 10 parts.
The preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation, step is:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 80 mesh sieves stand-by;
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 10 minutes, fry 3 minutes with slow fire, dry in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 2 days, be placed in non iron container, add the Chinese liquor of raw material gross weight 2 times, soak 2 hours, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 80 mesh sieves for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, add the water of raw material gross weight 1 times for the first time, intense fire is fried open, and turns slow fire boiling 10 minutes, and ceaselessly stirs, filter, obtain filtrate 1, second time adds the water of raw material gross weight 0.5 times, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 60 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
External application JIEGU GAO that what embodiment 2 one kinds promoted the injury of the bone to heal invigorate blood circulation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Semen Litchi 20 parts, Radix Salviae Miltiorrhizae 25 parts, Radix Dipsaci 15 parts, Myrrha 25 parts, Semen Momordicae 8 parts, Olibanum 24 parts, 30 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 40 parts, Rhizoma Drynariae 27 parts, Fructus Liquidambaris 17 parts, Rhizoma Chuanxiong 35 parts, Concha Arcae 10 parts, the Radix Astragali 35 parts, Juncus amplifolius A. Camus 20 parts, Flos Lonicerae 20 parts.
The preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation, step is:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 120 mesh sieves stand-by:
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 20 minutes, fry 8 minutes with slow fire, dry in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 6 days, be placed in non iron container, add the Chinese liquor of raw material gross weight 4 times, soak 8 hours, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 120 mesh sieves for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, add the water of raw material gross weight 3 times for the first time, intense fire is fried open, and turns slow fire boiling 15 minutes, and ceaselessly stirs, filter, obtain filtrate 1, second time adds the water of raw material gross weight 1.5 times, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 70 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
External application JIEGU GAO that what embodiment 3 one kinds promoted the injury of the bone to heal invigorate blood circulation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Semen Litchi 13 parts, Radix Salviae Miltiorrhizae 14 parts, Radix Dipsaci 8 parts, Myrrha 18 parts, Semen Momordicae 4 parts, Olibanum 16 parts, 23 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 25 parts, Rhizoma Drynariae 15 parts, Fructus Liquidambaris 7 parts, Rhizoma Chuanxiong 28 parts, Concha Arcae 6 parts, Radix Astragali 28-33 part, Juncus amplifolius A. Camus 16 parts, Flos Lonicerae 13 parts.
The preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation, step is:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 90 mesh sieves stand-by;
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 13 minutes, fry 4 minutes with slow fire, dry in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 3 days, be placed in non iron container, add the Chinese liquor of raw material gross weight 2.5 times, soak 4 hours, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 90 mesh sieves for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, add the water of raw material gross weight 1.5 times for the first time, intense fire is fried open, and turns slow fire boiling 11 minutes, and ceaselessly stirs, filter, obtain filtrate 1, second time adds the water of raw material gross weight 0.8 times, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 63 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
External application JIEGU GAO that what embodiment 4 one kinds promoted the injury of the bone to heal invigorate blood circulation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Semen Litchi 18 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Dipsaci 13 parts, Myrrha 23 parts, Semen Momordicae 6 parts, Olibanum 20 parts, 28 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 35 parts, Rhizoma Drynariae 25 parts, Fructus Liquidambaris 10 parts, Rhizoma Chuanxiong 33 parts, Concha Arcae 8 parts, the Radix Astragali 33 parts, Juncus amplifolius A. Camus 19 parts, Flos Lonicerae 18 parts.
The preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation, step is:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 110 mesh sieves stand-by;
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 18 minutes, fry 7 minutes with slow fire, dry in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 5 days, be placed in non iron container, add the Chinese liquor of raw material gross weight 3.5 times, soak 6 hours, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 110 mesh sieves for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, add the water of raw material gross weight 2.5 times for the first time, intense fire is fried open, and turns slow fire boiling 14 minutes, and ceaselessly stirs, filter, obtain filtrate 1, second time adds the water of raw material gross weight 1.3 times, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 68 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
External application JIEGU GAO that what embodiment 5 one kinds promoted the injury of the bone to heal invigorate blood circulation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Semen Litchi 15 parts, Radix Salviae Miltiorrhizae 17 parts, Radix Dipsaci 10 parts, Myrrha 20 parts, Semen Momordicae 5 parts, Olibanum 18 parts, 25 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 30 parts, Rhizoma Drynariae 20 parts, Fructus Liquidambaris 9 parts, Rhizoma Chuanxiong 30 parts, Concha Arcae 7 parts, the Radix Astragali 30 parts, Juncus amplifolius A. Camus 17 parts, Flos Lonicerae 15 parts.
The preparation method of above-mentioned external application JIEGU GAO of invigorating blood circulation, step is:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 100 mesh sieves stand-by;
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 15 minutes, fry 6 minutes with slow fire, dry in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 4 days, be placed in non iron container, add the Chinese liquor of raw material gross weight 3 times, soak 5 hours, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 100 mesh sieves for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, add the water of raw material gross weight 2 times for the first time, intense fire is fried open, and turns slow fire boiling 13 minutes, and ceaselessly stirs, filter, obtain filtrate 1, second time adds the water of raw material gross weight 1 times, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 65 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
Experimental example object is to verify originally invigorates blood circulation external application JIEGU GAO to promoting whether bone injury healing has curative effect." new Chinese medicine guideline of clinical investigations " according to Ministry of Public Health formulation in 1993 is diagnosis basis, and totally 400 routine patient with bone fracture, the mean age is 50 years old.Random division is administration group and matched group.
Before the experiments one day, record patient health, look over patient body symptom every day, guarantee administration group and matched group situation basically identical.Administration group to use this product embodiments 5 gained to invigorate blood circulation external application JIEGU GAO every day, within 10 days, is a course for the treatment of.Check patient body situation every day, make a record.Result is as following table 1:
Table 1:
Efficacy analysis: when administration group (the present invention invigorate blood circulation external application JIEGU GAO) uses 5 days, most patient sensory symptoms obviously alleviates, obviously feel to take a favorable turn in affected part, patient's emotion takes a turn for the better, during medication 20 days, patient is almost recovered, drug withdrawal a period of time has no repeatedly, the state of an illness is better controlled, matched group take medicine after curative effect obvious.The present invention invigorates blood circulation external application JIEGU GAO instant effect, can reach the object alleviating rapidly patient's misery, and relapse rate is low, is a kind of external application JIEGU GAO of invigorating blood circulation promoting bone injury healing safely and effectively.
Claims (10)
1. the external application JIEGU GAO of invigorating blood circulation promoting the injury of the bone to heal, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Semen Litchi 10-20 part, Radix Salviae Miltiorrhizae 10-25 part, Radix Dipsaci 5-15 part, Myrrha 15-25 part, Semen Momordicae 3-8 part, Olibanum 12-24 part, Pericarpium Citri Reticulatae Viride 20-30 part, cirsii japonici,radix 20-40 part, Rhizoma Drynariae 13-27 part, Fructus Liquidambaris 4-17 part, Rhizoma Chuanxiong 25-35 part, Concha Arcae 4-10 part, Radix Astragali 20-35 part, Juncus amplifolius A. Camus 15-20 part, Flos Lonicerae 10-20 part.
2. the external application JIEGU GAO of invigorating blood circulation of promotion injury of the bone healing according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Semen Litchi 13-18 part, Radix Salviae Miltiorrhizae 14-20 part, Radix Dipsaci 8-13 part, Myrrha 18-23 part, Semen Momordicae 4-6 part, Olibanum 16-20 part, Pericarpium Citri Reticulatae Viride 23-28 part, cirsii japonici,radix 25-35 part, Rhizoma Drynariae 15-25 part, Fructus Liquidambaris 7-10 part, Rhizoma Chuanxiong 28-33 part, Concha Arcae 6-8 part, Radix Astragali 28-33 part, Juncus amplifolius A. Camus 16-19 part, Flos Lonicerae 13-18 part.
3. the external application JIEGU GAO of invigorating blood circulation of promotion injury of the bone healing according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Semen Litchi 15 parts, Radix Salviae Miltiorrhizae 17 parts, Radix Dipsaci 10 parts, Myrrha 20 parts, Semen Momordicae 5 parts, Olibanum 18 parts, 25 parts, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix 30 parts, Rhizoma Drynariae 20 parts, Fructus Liquidambaris 9 parts, Rhizoma Chuanxiong 30 parts, Concha Arcae 7 parts, the Radix Astragali 30 parts, Juncus amplifolius A. Camus 17 parts, Flos Lonicerae 15 parts.
4. the preparation method of the external application JIEGU GAO of invigorating blood circulation of the promotion injury of the bone healing according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Semen Litchi and Concha Arcae are cleaned, it is crisp to be placed in smokeless stove fire forging, grinds to form smalls, crosses 80-120 mesh sieve stand-by;
(2) by clean to Myrrha, Semen Momordicae and Juncus amplifolius A. Camus even with white vinegar spray, slightly stewing 10-20 minute, fries 3-8 minute with slow fire, dries in the air cool, take out the cool smalls that grinds to form that dries in the air stand-by;
(3) by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 2-6 days, be placed in non iron container, add raw material gross weight 2-4 Chinese liquor doubly, soak 2-8 hour, large iron pan is dryouied, the soaked crude drug of rapid input, parch is flavoursome when sending, and cools, and to cross 80-120 mesh sieve for subsequent use for pulverization altogether;
(4) step (1)-(3) gained crude drug mixing, add water, and decoct twice, first time adds raw material gross weight 1-3 water doubly, intense fire is fried open, and turns slow fire boiling 10-15 minute, and ceaselessly stirs, filter, obtain filtrate 1, second time adds raw material gross weight 0.5-1.5 water doubly, and big fire is heated to boiling, until boiling after 3 minutes, filter, obtain filtrate 2, filtrate 1 and filtrate 2 are mixed, must filtrate be mixed, put into medicinal residues after mixing filtrate being heated to boiling and stir and decoct to paste;
(5) getting step (4) gained thick paste is placed in container, and little fire is decocted slowly to 60-70 DEG C, adds Cera Flava, and stirs and decoct, and after Cera Flava melts completely, cools, bottles and obtain external application JIEGU GAO.
5. preparation method according to claim 4, is characterized in that: step (1) smalls crosses 90-110 mesh sieve stand-by (preferred, it is stand-by that smalls crosses 100 mesh sieves).
6. preparation method according to claim 4, is characterized in that: the slightly stewing 13-18 minute of step (2), fries 4-7 minute (preferred, slightly stewing 15 minutes, to fry 6 minutes with slow fire) with slow fire.
7. preparation method according to claim 4, it is characterized in that: step (3) is by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 3-5 days (preferred, by Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae, clean, cut into pieces, be placed in shady and cool ventilation place 4 days).
8. preparation method according to claim 4, it is characterized in that: step (3) adds Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae weight 2.5-3.5 Chinese liquor doubly (preferred, to add the Chinese liquor of Radix Salviae Miltiorrhizae, Radix Dipsaci, Olibanum, Pericarpium Citri Reticulatae Viride, cirsii japonici,radix, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Astragali, Fructus Liquidambaris and Flos Lonicerae weight 3 times).
9. preparation method according to claim 4, it is characterized in that: step (4) first time adds raw material gross weight 1.5-2.5 water doubly, intense fire is fried open, it is (preferred to turn slow fire boiling 11-14 minute, add the water of raw material gross weight 2 times for the first time, intense fire is fried open, and turns slow fire boiling 13 minutes).
10. preparation method according to claim 4, is characterized in that: step (5) little fire is decocted slowly to 63-68 DEG C, adds Cera Flava (preferred, little fire is decocted slowly to 65 DEG C, adds Cera Flava).
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