CN104687044B - Functional food for relieving male sexual dysfunction and resisting fatigue - Google Patents

Functional food for relieving male sexual dysfunction and resisting fatigue Download PDF

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Publication number
CN104687044B
CN104687044B CN201510055855.9A CN201510055855A CN104687044B CN 104687044 B CN104687044 B CN 104687044B CN 201510055855 A CN201510055855 A CN 201510055855A CN 104687044 B CN104687044 B CN 104687044B
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weight
functional food
radix ginseng
herba ecliptae
parts
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CN104687044A (en
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梁滨
刘英敏
林楚雄
何彩霞
杨立楷
李国伟
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GUANGDONG CHANGXING BIOTECHNOLOGY CO Ltd
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GUANGDONG CHANGXING BIOTECHNOLOGY CO Ltd
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Abstract

The invention discloses a functional food for relieving male sexual dysfunction and resisting fatigue. The functional food contains maca powder. The functional food disclosed by the invention is capable of obviously improving the testosterone concentration in blood plasma of a human body and the conversion rate of hepatic glycogen (the glucose concentration in the blood is maintained at a stable level and is not easily lowered due to continuous movement), so as to effectively relieve MSD and improve the anti-fatigue property of the human body.

Description

A kind of alleviation male sexual disorder, the functional food of resisting fatigue
Technical field
The present invention relates to a kind of functional food, and in particular to a kind of alleviation male sexual disorder, the function of resisting fatigue Property food.
Background technology
Male sexual disorder (MSD) refers to the various disorderly or defects of male's sexual, including libido suppresses (or libido Depressed, ISD), erection disturbance (ED) or sexual impotence and premature ejaculation (PE, also referred to as quickly ejaculation, ejaculate in advance or early sending out of ejaculating) And anorgasmy, it is more relevant with the secretion of the hormone such as testosterone, hydrocortisone.Using PDE5 inhibitor, such as sldenafil (sildenafil), Vardenafil (vardenafil) and tadanafil (tadalafil), can successful treatment ED.At present to PE Successful treatment include reducing anesthesia frost (such as lignocaine, prilocaine and combinations thereof) and SSRI antidepressants of penile sense Agent, such as paroxetine, fluoxetine and Sertraline, but its effect is unsatisfactory and excessive use has obvious untoward reaction.This Outward, testosterone also has the effect for promoting skeletal muscle and bone growth, stimulating erythropoiesis, increase Body development deposit, with human body Motor capacity, the growth of muscle strength, the elimination etc. of fatigue have close relationship.Research shows that long-time large amount of exercise is instructed Practice or overtraining can cause in blood testosterone concentration to decline, this phenomenon be referred to as " motion hypogonadism " or " the low testosterone of motor type ".
The content of the invention
In view of this, the present invention disclose one kind can significantly improve human body anti-fatigue ability, while effective alleviation male's property work( The functional food of energy obstacle.
The purpose of the present invention is achieved through the following technical solutions:A kind of alleviation male sexual disorder, the function of resisting fatigue Property food, its raw material includes by weight:
Also include 100~230 parts by weight Fructus Jujubaes, 20~30 parts of Rhizoma Polygonatis, 200~300 parts of maltose syrup.
The pueraria root powder can select any one commercially available prior art and realize.For the only floating heart of Cruciferae (Cruciferae) Category (Lepidium) plant, scientific name Lepidium meyenii.It is generally acknowledged that Lepidinm meyenii Walp has resisting fatigue, sperm quality is improved, supplemented Muscle power, improves the health care of sleep, anti-climacteric, fertility is enlivened, the effects such as hypermnesis.But the effective ingredient in Lepidinm meyenii Walp plant receives extraction side The impact of the conditions such as method, quality is more unstable.Zoopery simultaneously and clinic also indicate that directly oral card agate powder is to alleviating MSD, resisting fatigue effect it is unobvious.And easily cause anaphylaxiss by the way of injection.The Lepidinm meyenii Walp of the present invention is selected Pueraria root powder made by the Lepidinm meyenii Walp of South America andes region, water content should control between 0-2% (free state water).
The sodium carboxymethyl cellulose, also known as:Sanlose, carboxymethyl cellulose, CMC, Carboxymethyl, Cellulose Sodium, Sodium salt of Caboxy Methyl Cellulose, are a kind of Food additive, is usually used in thickening agent, the binding agent as food.The sodium carboxymethyl cellulose of the present invention can select any one and show There is technology to realize.
The molecular formula of the Sorbitol is C6H14O6.It is common sweetening agent.
The Radix Ginseng extract refers to collection from fresh Araliaceae Radix Ginseng (Panax ginseng C.A.Mey), Herb, can select the prior arts such as extraction, two-phase extraction and obtains.Radix Ginseng has certain anti-fatigue effect.The Radix Ginseng of the present invention For fresh Radix Ginseng Herb (containing blade, stem, root).
Designer has found under study for action, and a small amount of sodium carboxymethyl cellulose and micro sorbose is added in Lepidinm meyenii Walp product Alcohol, and appropriate Radix Ginseng is equipped with, sensitivity of the human body to Lepidinm meyenii Walp product can be effectively improved, hence it is evident that improve the testis in human plasma The conversion rate of ketone concentration and hepatic glycogen (shows as the concentration of glucose in blood to maintain stable level and be difficult because continuing Motion declines), so as to effectively alleviating MSD and improving the anti-fatigue performance of human body.Arbitrarily remove sodium carboxymethyl cellulose or Pyrusussuriensiss Any one of sugar alcohol, the effect above disappears therewith.
Using above-mentioned composition, the health product of any one form, such as Maca health wine, guarantor can be configured to reference to known technology Strong beverage, tablet etc..To improve, neutralizing the property of medicine of Lepidinm meyenii Walp sum, its stimulation to digestion is reduced, can be with to formula It is middle to add 100~230 parts by weight Fructus Jujubaes, 20~30 parts of Rhizoma Polygonatis, 200~300 parts of maltose syrup.Fructus Jujubae, Rhizoma Polygonati etc. are Commercially available drying product.
Also include rice wine that 400~650 parts by weight ethanol mass fractions are 30~50% and 300~400 parts Deionized water.
It is preferred that, also including 0.2~0.9 part of Herba Ecliptae leaf extract;
The Radix Ginseng extract refers to that Radix Ginseng Herb is crushed after the granule for 0.9~1.5mm, and addition weight is granule fresh weight 10~30 times of mass fraction is that in 5~8% acetic acid solution, blowing air stands 20~30 at a temperature of 35~45 DEG C Afterwards, add and after infusion 30~50 minutes, filter the filtrate for obtaining at 70~80 DEG C with the ethanol of the weight such as acetic acid solution;
The Herba Ecliptae leaf extract refers to that Herba Ecliptae blade is crushed after the granule for 1~3mm, is immersed in quality for ink drought It is little with 1~6 DEG C of cold preservation 14 again after being heated 10 hours with 50~60 DEG C successively daily in the Mel of 20~25 times of lotus fresh weight When, obtain the ecliptae herba leaf extract after processing 5~15;
The pueraria root powder refers to that Lepidinm meyenii Walp root stands 20~50 at 70~80 DEG C, in the environment that relative humidity is 60% Afterwards, Jing after 90~95 DEG C of drying 5 hours, the material of the particle diameter of size-reduced acquisition in 0.5~0.8mm.
Ecliptae herba, also referred to as Eclipta prostrata (Eclipta prostrata), are feverfews, it is considered that can promote hair growth. The extract of ecliptae herba blade is added in Lepidinm meyenii Walp product, particularly ought be had in the presence of sodium carboxymethyl cellulose, can after taking The concentration (high sensitive) of testosterone in blood plasma is improved in short time, and the testosterone of this concentration is maintained in longer time.
Relative to the Radix Ginseng extract that common extraction or extraction are obtained, it is immersed in acetic acid high temperature and ferments more than 20 days Radix Ginseng ethanol extraction show the promotion muscle growth effect for becoming apparent from, Jing after feeding, the weightening of the hindlimb muscle of mice 4-12%.
Ecliptae herba blade is placed in into Mel high temperature to process, the Organic substance contributed in ecliptae herba occurs brown stain, obtains institute State the effect that testosterone concentration is improved in the short time.Without the ecliptae herba leaf extract of the process, the effect is weaker.K cryogenic treatment Effect be promote effective ingredient separate out from ecliptae herba.The Mel is any one prior art.Fructose in Mel, The material such as vitamin and Apidae animal secretions
Jing high temperature, the Lepidinm meyenii Walp root of high humidity treatment, testosterone concentration is better in its raising blood plasma.
A kind of method for preparing the functional food, including following operation:By the pueraria root powder add volume for its 20 In~30 times of deionized water, the sodium carboxymethyl cellulose is added after being heated to 80~85 DEG C, continue to be heated to 90 DEG C and protect 3~7min is held, the Sorbitol, Radix Ginseng extract, Herba Ecliptae leaf extract is added after being cooled to 60~67 DEG C, insulation 20~ Described functional food is obtained after 30min.
Specific embodiment
For the ease of it will be appreciated by those skilled in the art that being described in further detail to the present invention below in conjunction with embodiment:
Embodiment 1
The present embodiment provides a kind of alleviation male sexual disorder, the functional food of resisting fatigue, and its raw material is by weight Including:
Further, also including 0.5 part of Herba Ecliptae leaf extract;
The Radix Ginseng extract refers to that Radix Ginseng Herb is crushed after the granule for 0.9~1.5mm, and addition weight is granule fresh weight 20 times of mass fraction is in 7% acetic acid solution, after blowing air stands 20 at a temperature of 40 DEG C, adds and acetic acid solution Ethanol Deng weight after infusion 40 minutes, filters the filtrate for obtaining at 80 DEG C;
The Herba Ecliptae leaf extract refers to that Herba Ecliptae blade is crushed after the granule for 1~3mm, is immersed in quality for ink drought In the Mel of 20 times of lotus fresh weight, daily successively, again with 1 DEG C of cold preservation 14 hours, processing 10 after 60 DEG C of heating 10 hours After obtain the ecliptae herba leaf extract;
After the pueraria root powder refers to that Lepidinm meyenii Walp root stands 30 at 75 DEG C, in the environment that relative humidity is 60%, 91 DEG C of Jing After drying 5 hours, the material of the particle diameter of size-reduced acquisition in 0.5~0.8mm.
The present embodiment also provides a kind of method for preparing above-mentioned functions food, including following operation:By the pueraria root powder Add volume to be in its 30 times deionized water, the sodium carboxymethyl cellulose to be added after being heated to 80 DEG C, continue to be heated to 90 DEG C and keep 7min, add the Sorbitol, Radix Ginseng extract, Herba Ecliptae leaf extract after being cooled to 60 DEG C, be incubated 20min Described functional food is obtained afterwards.
Embodiment 2
The present embodiment provides a kind of alleviation male sexual disorder, the functional food of resisting fatigue, and its raw material is by weight Including:
Further, also including 0.9 part of Herba Ecliptae leaf extract;
The Radix Ginseng extract refers to that Radix Ginseng Herb is crushed after the granule for 0.9~1.5mm, and addition weight is granule fresh weight 10 times of mass fraction is in 8% acetic acid solution, after blowing air stands 30 at a temperature of 35 DEG C, adds and acetic acid solution Ethanol Deng weight after infusion 50 minutes, filters the filtrate for obtaining at 70 DEG C;
The Herba Ecliptae leaf extract refers to that Herba Ecliptae blade is crushed after the granule for 1mm, is immersed in quality for Herba Ecliptae In the Mel of 25 times of fresh weight, daily successively with after 50~60 DEG C of heating 10 hours again with 1~6 DEG C of cold preservation 14 hours, place Reason obtains the ecliptae herba leaf extract after 5 days;
After the pueraria root powder refers to that Lepidinm meyenii Walp root stands 20 at 80 DEG C, in the environment that relative humidity is 60%, 95 DEG C of Jing After drying 5 hours, the material of the particle diameter of size-reduced acquisition in 0.5mm.
Embodiment 3
The present embodiment provides a kind of alleviation male sexual disorder, the functional food of resisting fatigue, and its raw material is by weight Including:
Further, also including 0.2 part of Herba Ecliptae leaf extract;
The Radix Ginseng extract refers to that Radix Ginseng Herb is crushed after the granule for 1.5mm, and addition weight is 10 times of granule fresh weight Mass fraction be after blowing air stands 30 at a temperature of 35 DEG C, to add and the weight such as acetic acid solution in 8% acetic acid solution Ethanol after infusion 50 minutes, filter the filtrate for obtaining at 70 DEG C;
The Herba Ecliptae leaf extract refers to that Herba Ecliptae blade is crushed after the granule for 1~3mm, is immersed in quality for ink drought In the Mel of 20 times of lotus fresh weight, daily successively, again with 1 DEG C of cold preservation 14 hours, processing 15 after 50 DEG C of heating 10 hours After obtain the ecliptae herba leaf extract;
After the pueraria root powder refers to that Lepidinm meyenii Walp root stands 50 at 70 DEG C, in the environment that relative humidity is 60%, 90 DEG C of Jing After drying 5 hours, the material of the particle diameter of size-reduced acquisition in 0.8mm.
Embodiment 4
The present embodiment provides a kind of alleviation male sexual disorder, the functional food of resisting fatigue, and its raw material is by weight Including:
Further, also including 0.5 part of Herba Ecliptae leaf extract;
The Radix Ginseng extract refers to that Radix Ginseng Herb is crushed after the granule for 0.9~1.5mm, is Radix Ginseng fresh weight 20 in weight Times ethanol after infusion 40 minutes, filter the filtrate for obtaining at 80 DEG C;
The Herba Ecliptae leaf extract refers to that Herba Ecliptae blade is crushed after the granule for 1~3mm, is immersed in quality for ink drought The ecliptae herba leaf extract is obtained within 130 minutes in 20 times of deionized waters of lotus fresh weight with 60 DEG C of infusions;
The pueraria root powder is commercially available prod.
Embodiment 5
The present embodiment provides a kind of alleviation male sexual disorder, the functional food of resisting fatigue, and its raw material is by weight Including:
The pueraria root powder, sodium carboxymethyl cellulose, Sorbitol are commercially available prod.The Radix Ginseng extract refers to that Radix Ginseng is complete Strain is crushed after the granule for 0.9~1.5mm, adds the weight to be in 7% acetic acid solution for the mass fraction of 20 times of granule fresh weight, After blowing air stands 20 at a temperature of 40 DEG C, add with the ethanol of the weight such as acetic acid solution at 80 DEG C after infusion 40 minutes, Filter the filtrate for obtaining.
Comparative example 1
Our team's ratio provides a kind of functional food of resisting fatigue, and its raw material includes by weight:
80 parts of pueraria root powder;
10 parts of sodium carboxymethyl cellulose;
0.35 part of Radix Ginseng extract.
The pueraria root powder, sodium carboxymethyl cellulose, Sorbitol are commercially available prod.The Radix Ginseng extract refers to that Radix Ginseng is complete Strain is crushed after the granule for 0.9~1.5mm, adds the weight to be in 7% acetic acid solution for the mass fraction of 20 times of granule fresh weight, After blowing air stands 20 at a temperature of 40 DEG C, add with the ethanol of the weight such as acetic acid solution at 80 DEG C after infusion 40 minutes, Filter the filtrate for obtaining.
Comparative example 2
This comparative example provides the functional food of resisting fatigue, and its raw material includes by weight:
80 parts of pueraria root powder;
0.005 part of Sorbitol;
0.35 part of Radix Ginseng extract.
The pueraria root powder, sodium carboxymethyl cellulose, Sorbitol are commercially available prod.The Radix Ginseng extract refers to that Radix Ginseng is complete Strain is crushed after the granule for 0.9~1.5mm, adds the weight to be in 7% acetic acid solution for the mass fraction of 20 times of granule fresh weight, After blowing air stands 20 at a temperature of 40 DEG C, add with the ethanol of the weight such as acetic acid solution at 80 DEG C after infusion 40 minutes, Filter the filtrate for obtaining.
Mice plasma testosterone concentration is tested.
Adult male mice (113.11 ± 5.72g of body weight) is divided into into 7 groups, 50 per group, per group of difference gavage feeding reality Example 1, embodiment 2, embodiment 4, embodiment 5, comparative example 1, comparative example 2 and normal saline are applied, feeding dosage is 0.5g.Test Mice plasma testosterone concentration (radioimmunology) in feeding reagent 48 hours, concrete steps refer to what Niu Rui was delivered《Herba Epimedii To the impact of mice plasma testosterone and accessory sex organ before and after processing》(CHINA JOURNAL OF CHINESE MATERIA MEDICA, the 9th phase of volume 14, in September, 1989). Its result is as shown in table 1.
Mouse muscle growth test.
With above-mentioned dosage gavage medicament once a day, while the commercially available mouse feed of supply, arbitrarily takes food for mice.Ten days Afterwards, each group mice weights are counted, the front weight of weight and experiment is subtracted each other, obtain the average weight rate of increase of each group mice.As a result Such as table 2.
Experimental group Weight rate of increase (%)
Embodiment 1 50.31
Embodiment 2 52.20
Embodiment 4 42.11
Embodiment 5 36.23
Comparative example 1 10.22
Comparative example 2 9.91
Normal saline 10.38
Mouse blood sugar concentration determination.
10 mices of per group of selection, order about its swimming in being gone in off the deep end, mouse blood sugar concentration is tested after 60min.Its As a result it is as shown in table 3.
It is above the wherein specific implementation of the present invention, its description is more concrete and detailed, but can not therefore manage Solution is the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from On the premise of present inventive concept, some deformations and improvement can also be made, these obvious alternative forms belong to this Bright protection domain.

Claims (5)

1. a kind of to alleviate male sexual disorder, the functional food of resisting fatigue, its raw material includes by weight:
80 ~ 120 parts of pueraria root powder;
3 ~ 10 parts of sodium carboxymethyl cellulose;
0.005 ~ 0.009 part of Sorbitol;
0.05 ~ 0.35 part of Radix Ginseng extract;
Also include 0.2~0.9 part of Herba Ecliptae leaf extract;The Herba Ecliptae leaf extract refers to that Herba Ecliptae blade is crushed After for the granule of 1~3mm, in being immersed in the Mel that quality is 20~25 times of Herba Ecliptae fresh weight, daily according to It is secondary, again with 1~6 DEG C of cold preservation 14 hours, after processing 5~15 institute being obtained after 50~60 DEG C of heating 10 hours State Herba Ecliptae leaf extract;
The pueraria root powder refers to that Lepidinm meyenii Walp root stands 20~50 at 70~80 DEG C, in the environment that relative humidity is 60% In the future,
Jing after 90~95 DEG C of drying 5 hours, the material of the particle diameter of size-reduced acquisition in 0.5~0.8mm.
2. the functional food according to claim 1, it is characterised in that:Also include by weight 100~230 Part Fructus Jujubae, 20~30 parts of Rhizoma Polygonatis, 200~300 parts of maltose syrup.
3. the functional food according to claim 2, it is characterised in that:Also include by weight 400~650 Part ethanol mass fraction is 30~50% rice wine and 300~400 parts of deionized water.
4. the functional food according to any one of claim 1~3, it is characterised in that:
The Radix Ginseng extract refers to that Radix Ginseng Herb is crushed after the granule for 0.9~1.5mm, and addition weight is granule fresh weight 10~30 times of mass fraction is in 5~8% acetic acid solution, to be passed through air at a temperature of 35~45 DEG C quiet After putting 20~30, add and after infusion 30~50 minutes, filtered at 70~80 DEG C with the ethanol of the weight such as acetic acid solution The filtrate of acquisition.
5. a kind of method for preparing functional food described in claim 1, including following operation:The pueraria root powder is added Volume is in its 20~30 times deionized water, the sodium carboxymethyl cellulose to be added after being heated to 80~85 DEG C, after It is continuous to be heated to 90 DEG C and keep 3~7min, add after being cooled to 60~67 DEG C the Sorbitol, Radix Ginseng extract, Herba Ecliptae leaf extract, is incubated after 20~30min and obtains described functional food.
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CN105055492A (en) * 2015-08-12 2015-11-18 江苏艾兰得营养品有限公司 Preparation for tonifying Yang, strengthening body and improving immunity and preparation method of preparation
CN105296300A (en) * 2015-11-11 2016-02-03 王宝珍 Maca and ginseng liquor and production process thereof
CN105341606B (en) * 2015-12-04 2017-07-14 广东红珊瑚药业有限公司 A kind of maca health drink acted on antifatigue and increasing immune power and preparation method thereof
CN105614874B (en) * 2016-03-11 2019-04-05 海门品尚医药科技有限公司 A kind of composition improving fatigue state
CN107050089A (en) * 2017-03-29 2017-08-18 新疆旺源生物科技集团有限公司 It is a kind of to significantly increase maca composition of immunity function and preparation method thereof
CN110313530A (en) * 2019-07-04 2019-10-11 广东福东海药业有限公司 A kind of precious tea of ginseng five and preparation method thereof improving function of male

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CN102716263B (en) * 2012-07-12 2014-08-06 云南滇隆制药有限公司 Maca, ginseng and medlar composition and application thereof
KR101420781B1 (en) * 2012-12-07 2014-07-21 주식회사 대화약품 Method for manufacturing pill product using silkworm
CN103768123A (en) * 2014-02-24 2014-05-07 丽江云岭生物科技开发有限公司 Traditional Chinese medicine composition and preparation method thereof
CN103989166B (en) * 2014-05-09 2016-04-20 深圳市皇都御颜养生科技有限责任公司 A kind of health food improving male's sexual
CN104187952B (en) * 2014-08-14 2017-01-18 吉林省中医药科学院 Ginseng-sealwort composite sports health beverage

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