CN104675808A - Optical fiber based microfluid driving device and driving method - Google Patents
Optical fiber based microfluid driving device and driving method Download PDFInfo
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Abstract
The invention belongs to the field of microfluid control, and particularly relates to an optical fiber based microfluid driving device and driving method. The optical fiber based microfluid driving device comprises a miniature water tank 1, a quartz micro-tube 2, a microfluid 3, optical fiber 4, a light source 5 and an absorbing fluid 6, wherein the optical fiber and the quartz micro-tube are embedded into the miniature water tank and arranged on two sides of the miniature water tank; light emitted from the light source is projected into the miniature water tank through the optical fiber, so that the absorbing fluid in the tank generates heat convection motion, negative pressure is produced by heat convection motion at a port of the quartz micro-tube, and the microfluid in the quartz micro-tube flows into the miniature water tank. The quartz micro-tube is taken as a microfluid channel and the quartz micro-tube can be drawn like drawing of optical fiber according to structure parameters, the size and the structure of the microfluid channel can be flexibly controlled, the technology is mature, the manufacture is simple, and the cost is low.
Description
Technical field
The invention belongs to microfluidic control field, particularly a kind of optical fiber microfluid drive and method for driving.
Background technique
Microfluidic control technology refers to that in having at least one dimension to be micron even the low-dimensional channel design of nanoscale, to control volume is that skin rises to and receives the fluid risen and carry out flowing and the technology of mass transfer, heat transfer, can be widely used in the various fields such as biochemical analysis, immunoassay, micro-wound surgical operation, environmental monitoring.
The key technology of microfluidic control mainly comprises: the integrated and encapsulation of the design and manufaction of Micro Channel Architecture, the driving of micro/nano-scale fluid and control and microfluid control device and system.And the driving of the design and manufaction of Micro Channel Architecture and micro/nano-scale fluid and control are the prerequisites of microfluidic control.
In microfluidic system, fluid needs to flow in some way in the micro passage of certain size and structure, to reach the object of heat transfer, mass transfer and MOMENTUM TRANSMISSION, is the core of microfluidic system.Silicon and glass material process micro passage and mainly adopts photoetching and lithographic technique, but photoetching process is harsh to substrate surface quality requirement, complex process, needs expensive exposure and etching apparatus, the deficiencies such as cost is higher, yield rate is lower.The processing of polymer-based material adopts soft lithography usually, but organic substance poor thermal conductivity, non-refractory, processing technology and micro-manufacturing process are incompatible, makes it be subject to a definite limitation in the application of microflow control technique.
In addition, the resistance that fluid flows in the passage of micro/nano-scale is very large, forming effective driving and can have multiple method, as adopted syringe pump, air pump, wriggling Micropump etc. to carry out pressure-driven, or utilizing the phenomenons such as the wetting and dielectric fluid of electroosmotic flow, electrophoresis, electricity to realize electric power to drive.Microfluid flow is atomic, flow velocity is controlled, low cost and longevity of service to adopt which kind of driving mode all will consider.
At present, the driving of microfluid and control technique kind a lot, as divided by principle, can be divided into pressure-driven, electric hydro powered, driven by electroosmosis, thermal drivers, surface tension driving, centrifugal force driving etc.Pressure-driven mode is the modal driving mode of micro-fluidic chip, is the motion of fluid under pressure gradient effect.Syringe pump, air pump, wriggling Micropump etc. is adopted all to belong to pressure-driven.The microfluidic control of the injection pump type mentioned in the article " Preparation of CdSe nanocrystals in a micro-flow-reactor " of the people such as Nakamura H, microsyringe is used to be controlled the injection of microfluid fast accurately by temperature, the control of molecule can be realized, and can reuse, this article is published in Chemical Communications, on 2002 (23): 2844-2845; Patent " micro fluid dynamcis and speed control unit and method " (application number: CN200510135579.3) of the application such as the green pearl of Industrial Technology Research Institute of Taiwan Province Wu is also a kind of piston is in addition pressure-driven method.This piston-type pressure method for driving controls microfluid, complex structure, operating difficulties owing to adopting outer piston, and integrated difficulty is high, describe diaphragm pump and peristaltic pump in the article " Surface micromachined electrostatically actuated micro peristaltic pump " of the people such as the article " Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices " of the people such as Grover W H and Xie J respectively to produce pressure and (be published in Sensors and Actuators B:Chemical respectively in order to drive the method for microfluid, 2003, 89 (3): 315-323 and Lab on a Chip, 2004, on 4 (5): 495-501), in addition a variety of pressure-driven method using mechanical pump as power is also had, what they were inevitable more or less will introduce mechanical structure or tiny device, this is disadvantageous concerning micro-fluidic chip.Therefore we have proposed a kind of new pressure-driven method---negative pressure method for driving, the method structure is simple, and pressure controlling section is separated contactless with micro-fluidic chip, is easy to realize microminiaturization, integrated.
Comprehensive above technology, we utilize method for drawing optical fibers to make a kind of quartzy microtubule as microfluidic channel, photic thermal effect is utilized to make liquid produce thermoconvection, utilize negative pressure that thermoconvection produces in quartzy microtubule mouth of pipe place Bernoulli effect as driving, propose a kind of novel microfluid drive and method for driving.
Summary of the invention
The object of the present invention is to provide a kind of based on the compact easy to operate optical fiber microfluid drive of optical fiber structure, the present invention also aims to provide a kind of optical fiber microfluid drive method for driving.
The object of the present invention is achieved like this:
Optical fiber microfluid drive, comprise mini flume 1, quartzy microtubule 2, microfluid 3, optical fiber 4, light source 5, absorption fluids 6, optical fiber and quartzy microtubule to embed in mini flume and are placed in mini flume both sides, the light sent from light source is incident on mini flume the absorption fluids generation thermoconvection campaign made in groove through optical fiber, thermoconvection campaign produces negative pressure at quartzy microtubule mouth of pipe place, and the microfluid in quartzy microtubule is produced to the flowing in mini flume.
Optical fiber is Single Mode Fiber, multi-mould optical fibre or photonic crystal fiber, and fiber end face is planar end surface, hemispherical end face, parabola shaped end face or tapered end face.
Light source emergent light wavelength is corresponding with an absworption peak wavelength of absorption fluids in mini flume or comprise multiple absworption peak.
Optical fiber and quartzy microtubule to embed in mini flume and are placed in mini flume both sides or have an angle.
Optical fiber micro fluid dynamcis method, the optical fiber of the optical fiber microfluid drive described in described in claim 1-4 and quartzy microtubule are embedded in mini flume, the light sent from light source is incident on mini flume the absorption fluids generation thermoconvection campaign made in groove through Optical Fiber Transmission, thermoconvection campaign produces negative pressure at quartzy microtubule mouth of pipe place, microfluid in quartzy microtubule is flowed in mini flume, by regulating the microfluid rate of outflow in light source power size adjustment quartz microtubule.
Beneficial effect of the present invention is:
The present invention uses quartzy microtubule as microfluidic channel, and the structural parameter of quartzy microtubule can draw as the method for drawing optical fiber, can control size, the structure of microfluidic channel flexibly, and technology maturation, making is simple, cost is low.The liquid convection that the present invention utilizes the thermal effect of photic liquid to produce cleverly, produces negative pressure as pressure-driven power at microfluidic channel mouth, avoids microfluid and contact with the direct of pressurization device.Adopt optical fiber to transmit as light energy, through-put power is high, compact structure, is conducive to the integrated of device and miniaturization.Can according to the power of the size adjustment fiber exit light of light source power, thus the convection velocity in regulates liquid, regulate the pressure size of microfluidic channel mouth, realize the flowing velocity that highi degree of accuracy regulates microfluid.
Accompanying drawing explanation
Fig. 1 is that the present invention's quartz microtubule and fiber-coaxial place stereogram.
Fig. 2 is the present invention's quartz microtubule and fiber-coaxial setting side view.
Fig. 3 is that the present invention's quartz microtubule and optical fiber have an angle plan view.
Fig. 4 is the present invention's quartzy micro-tubular structure schematic diagram used.
Embodiment
Be described further below in conjunction with embodiment and accompanying drawing the present invention, but should do not limit the scope of the invention with this.
The present invention utilizes photic thermal effect, and the light that light source sends, by Optical Fiber Transmission outgoing in a liquid, produces photic thermal effect, makes flow of fluid, in quartzy microtubule interruption-forming negative pressure, realizes microfluid and flows out.
Optical fiber microfluid drive, comprises mini flume 1, quartzy microtubule 2, microfluid 3, optical fiber 4, light source 5, absorption fluids 6; It is characterized in that: optical fiber 4 and quartzy microtubule 2 to embed in mini flume 1 and be placed in mini flume 1 both sides, end face is at a distance of suitable distance, the light sent from light source 5 is incident on mini flume 1 through optical fiber 4 and makes the absorption fluids 6 in groove produce thermoconvection campaign, thermoconvection campaign produces negative pressure at quartzy microtubule 2 mouth of pipe place, and the microfluid 3 in quartzy microtubule 2 is produced to the flowing in mini flume 1.
Described a kind of optical fiber microfluid drive, is characterized in that: described optical fiber 4 can be Single Mode Fiber, multi-mould optical fibre or photonic crystal fiber, and optical fiber 4 end face can be planar end surface, hemispherical end face, parabola shaped end face or tapered end face.
Described a kind of optical fiber microfluid drive, is characterized in that: described light source 5 emergent light wavelength should be corresponding with an absworption peak wavelength of absorption fluids 6 in mini flume 1 or comprise multiple absworption peak.
Described a kind of optical fiber microfluid drive, is characterized in that: described optical fiber 4 and quartzy microtubule 2 to embed in mini flume 1 and be placed in mini flume 1 both sides or have an angle.
A kind of optical fiber micro fluid dynamcis method, it is characterized in that: the optical fiber 4 of the described optical fiber microfluid drive of claim 1-4 is embedded in mini flume 1 with quartzy microtubule 2, end face is at a distance of suitable distance, the light sent from light source 5 is incident on mini flume 1 through optical fiber 4 transmission and makes the absorption fluids 6 in groove produce thermoconvection campaign, thermoconvection campaign produces negative pressure at quartzy microtubule 2 mouth of pipe place, microfluid 3 in quartzy microtubule 2 being flowed in mini flume 1, regulating microfluid 3 rate of outflow in quartzy microtubule 2 by regulating light source 5 watt level.
Working principle:
Because material selectively absorbs light, any one liquid all can have the dark line spectrum of the light of oneself correspondence, after the energy of light is by liquid absorption, be converted into heat.Fiber exit illumination is mapped in liquid, there is action of thermal difference because light distribution is uneven, and the liquid that temperature is high rises, and the liquid that temperature is low supplements rapidly and heats, thus near light field, forms thermoconvection.Fast specific to microtubule mouth of pipe liquid flow velocity quartzy in the present invention, form negative pressure by Bernoulli effect is known at the mouth of pipe, the microfluid realized in quartzy microtubule flows out.
The present invention can be realized by following mode: as shown in Figure 1.
In the sustained height perforate of a mini flume 1, respectively quartzy microtubule 2 and optical fiber 4 are passed from hole and then quartzy microtubule 2 is fixed with epoxy resin apart from suitable with optical fiber 4, quartz microtubule 2 inside is filled with microfluid 2, optical fiber 4 is connected with light source 5, pour in mini flume 1 the absorbent liquid 6 of light source 5 wavelength, make it the height of liquid level higher than quartzy microtubule 2 and optical fiber 4;
When light is transferred in absorptivity liquid 6 by optical fiber 4 by light source 5, due to the absorption heat production of liquid 6 pairs of light waves, the liquid flows upwards that temperature is high for liquid 6, the liquid that temperature is low supplements rapidly and heats, forms convection current, at quartzy microtubule 2 mouth of pipe place because the flowing generation Bernoulli effect of liquid, produce negative pressure, microfluid 3 in quartz microtubule 2 outflows, and realizes the driving of optical fiber microfluid, and regulates the watt level of light source 5 can control the flowing velocity of microfluid 3.
Embodiment one: the making of optical fiber microfluid drive.Step is as follows:
1, the mini flume 1 one of long 25mm, wide 5mm, high 10mm top-open is first got, get the quartzy microtubule 2 one sections of external diameter 125 μm, internal diameter 20 μm, long 0.5m, get the common standard Single Mode Fiber 4 one sections of length 1m, get the power-adjustable 1480nm laser source 5 one with FC interface.
2, open at got mini flume 1 both sides height 4mm positional symmetry the aperture that a diameter is 0.5mm respectively, by smooth for the cutting of the two ends optical fiber cutter of got quartzy microtubule 2, the coating layer of got common standard Single Mode Fiber 4 one end peeled off 20 ~ 30mm and utilize optical fiber cutter cut smooth and remain naked fine length and be about 10mm.The quartzy microtubule 2 handled well and bare fibre 4 are penetrated inside from the two ends aperture of mini flume 1 respectively, make the both ends of the surface of quartzy microtubule 2 and bare fibre 4 at a distance of about 300 μm and coaxially, utilize epoxy resin respectively quartzy microtubule 2 and bare fibre 4 to be fixed on the two ends of mini flume 1.
3,20 ~ 30mm coating layer is peeled off in the one end being fixed on the common standard Single Mode Fiber 4 of mini flume 1 side, optical fiber cutter cutting is utilized smoothly to make the naked fine length 12mm of residue, insert fiber active linker to be connected with 1480nm laser source, thus the optical fiber microfluid drive that completed.
Embodiment two: utilize optical fiber microfluid drive to realize a kind of micro fluid dynamcis, as shown in Figure 1.
1, as after embodiment one step makes optical fiber microfluid drive, the distilled water 6 larger to 1480nm optical band absorptivity is poured in mini flume 1, until liquid level height reaches 8 ~ 9mm position, now due to the capillarity of quartzy microtubule 2, in quartzy microtubule 2, be full of distilled water 6.
2, the other end of the quartzy microtubule 2 handled well is placed in microfluid 3 rhodamine B solution pool, the height in microfluid pond is regulated according to law of connected vessels, liquid pressure in quartzy microtubule 2 is balanced, and the microfluid 3 rhodamine B solution namely in quartzy microtubule 2 is in steady state.
3,1480nm laser source 5 power is regulated to make it minimum, open 1480nm laser source 5, observe the flowing of water in mini flume 1, because the mouth of pipe flowing over quartzy microtubule 2 of water in mini flume 1 forms negative pressure, microfluid 3 rhodamine B solution in quartz microtubule 2 outwards flows out, the speed regulating the size of 1480nm laser source 5 power can change the red bright B solution of sieve microfluid 3 in quartzy microtubule 2 outwards to flow out.So far we achieve the micro fluid dynamcis to the microfluid 3 rhodamine B solution in quartzy microtubule 2.
Claims (5)
1. an optical fiber microfluid drive, comprise mini flume (1), quartzy microtubule (2), microfluid (3), optical fiber (4), light source (5), absorption fluids (6), it is characterized in that: optical fiber and quartzy microtubule to embed in mini flume and be placed in mini flume both sides, the light sent from light source is incident on mini flume the absorption fluids generation thermoconvection campaign made in groove through optical fiber, thermoconvection campaign produces negative pressure at quartzy microtubule mouth of pipe place, and the microfluid in quartzy microtubule is produced to the flowing in mini flume.
2. a kind of optical fiber microfluid drive according to claim 1, is characterized in that: described optical fiber is Single Mode Fiber, multi-mould optical fibre or photonic crystal fiber, fiber end face is planar end surface, hemispherical end face, parabola shaped end face or tapered end face.
3. a kind of optical fiber microfluid drive according to claim 1, is characterized in that: described light source emergent light wavelength is corresponding with an absworption peak wavelength of absorption fluids in mini flume or comprise multiple absworption peak.
4. a kind of optical fiber microfluid drive according to claim 1, is characterized in that: described optical fiber and quartzy microtubule to embed in mini flume and be placed in mini flume both sides or have an angle.
5. an optical fiber micro fluid dynamcis method, it is characterized in that: the optical fiber of the optical fiber microfluid drive described in described in claim 1-4 and quartzy microtubule are embedded in mini flume, the light sent from light source is incident on mini flume the absorption fluids generation thermoconvection campaign made in groove through Optical Fiber Transmission, thermoconvection campaign produces negative pressure at quartzy microtubule mouth of pipe place, microfluid in quartzy microtubule is flowed in mini flume, by regulating the microfluid rate of outflow in light source power size adjustment quartz microtubule.
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Cited By (2)
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| CN106582903A (en) * | 2016-12-26 | 2017-04-26 | 华南师范大学 | Micro-fluidic chip based on photothermal waveguide and micro-fluidic method of micro-fluidic chip |
| CN111617683A (en) * | 2020-04-10 | 2020-09-04 | 桂林电子科技大学 | Photothermal microfluidic mixer based on porous optical fiber |
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