CN104667130A - Traditional Chinese medicinal preparation for treating menstrual cycle disorder and preparation method for traditional Chinese medicinal preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating menstrual cycle disorder. The traditional Chinese medicinal preparation is prepared from the following main raw medicinal materials in parts by weight: 15 to 20 parts of fructus amomi, 10 to 20 parts of purslane, 10 to 20 parts of cuttle bone, 8 to 12 parts of myristica fragrans, 8 to 15 parts of carthamus fruit, 12 to 20 parts of oyster, 9 to 16 parts of gizzard pepsin, 8 to 15 parts of polygala tenuifolia, 10 to 20 parts of tangerine peel, 4 to 9 parts of Chinese banana root, 15 to 30 parts of astragalus membranaceus, 15 to 20 parts of atractylodes, 6 to 10 parts of bryozoatum, and 10 to 20 parts of ophiopogon japonicas. The traditional Chinese medicinal preparation has the effects of strengthening the spleen, benefiting qi, nourishing the liver and the kidneys, clearing heat, regulating the menstruation, relieving the liver for smooth qi, activating the blood and removing stasis, and has a good treatment effect on the menstrual cycle disorder.

Description

The Chinese medicine preparation for the treatment of the confusion of the menstrual cycle and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of the confusion of the menstrual cycle.

Background technology

The confusion of the menstrual cycle refers to the disease relevant with menstruation, the symptom of the confusion of the menstrual cycle: 1. advanced menstruation: menstruation refers to that menstrual cycle shortens in advance, is shorter than 21 days, and there are more than 2 cycles continuously, belong to ovulation type anovulatory dysfunctional uterine hemorrhage basal body temperature two-phase, follicular phase is short, only 7,8 days; Or luteal phase is shorter than 10 days, or body temperature rising is less than 0.5 degree Celsius.2. postpone menstrual period: menstruation misses more than 7 days, even 40-50 days a line, and occur the symptom of more than 2 menstrual cycle continuously.Have ovulation person, basal body temperature two-phase, but follicular phase is long, high-temperature-phase is on the low side; Anovulation person, basal body temperature is single-phase.3. menostaxis: the symptom main manifestations of this type of menoxenia is that menstrual cycle is normal, menostaxis, menstrual period, even 2 weeks sides were clean more than more than 7 days.Have inflammation person's lower abdomen pain at ordinary times, menstrual period increase the weight of, and leucorrhea amount is many at ordinary times, and yellow skin or HUANGBAI(sic), matter is thick, have taste.The infull person of atrophy of corpus iuteum is simultaneously with menorrhagia; Endometrium reparation prolongs elder at menorrhea after date, still has the symptom of a small amount of persistence vaginal hemorrhage to occur.4. menstruation is successively irregularly: menstruation in advance or postpone, cycle or be shorter than 21 days, or be longer than 35 days.

Menoxenia has some Nervous and Mental Factors, spiritual hypertonicity, and grief and indignation, sorrow, annoyed these can cause the confusion of the menstrual cycle.Occur that menstrual cycle is forbidden, in advance, postpone, without regularly, too much, very few through measuring, color and luster is purple black or light red, and thick or thin etc. through blood concentration, menstruation should be all rule in the most of the time of female fertility phase.But along with rhythm of life is fast, operating pressure is large, environment change and take the factors such as inappropriate means fat-reducing, a lot of women is made to occur menoxenia, women's generation menstruation is by the interactional result in cerebral cortex, hypothalamus, hypophysis cerebri, ovary and uterus, by Neuroendocrine regulation.When people is in the situations such as overstrain, fear, sorrow, overworked and operation, the function in hypothalamus, hypophysis cerebri, ovary, uterus can be suppressed by neuroendocrine system, thus cause irregular menstruation.After somebody's menses are clean, spend a couple of days and taken again a bit, claim " menses are later ", this is sick at last, but a kind of normal phenomenon.The traditional Chinese medical science is thought, menoxenia is damaged by excess of seven emotions or diseases caused by exogenous pathogenic factor six climate exopathogens mainly, or congenital deficiency of kidney-QI, voluminous exhaustion due to sexual indulgence, and overstrain makes visceral-qi impaired, and kidney function of liver and spleen is not normal, disorder of QI and blood, sends out as menoxenia.

At present, the medicine for the treatment of the confusion of the menstrual cycle has a lot, for the problems referred to above, publication number CN 102579695 A (application number 201210076985.7) patent document discloses a kind of decoction for the treatment of menoxenia, and it is made up of the material of following weight proportioning: Flos Carthami 5-10 part, Cortex Phellodendri 5-15 part, Radix Rubiae 1-5 part, Radix Angelicae Dahuricae 3-8 part, Herba Leonuri 0.1-0.5 part, Herba Violae 3-10 part, Fructus Corni 5-10 part, Poria 3-8 part, Radix Angelicae Sinensis 5-10 part, Cortex Moutan 10-20 part and/or water 50-100 part.Publication number CN104161270 A(application number 201410130513.4) patent document discloses a kind of medicament for the treatment of menoxenia, be prepared from by the medical material of following weight proportion: Embelia parviflora Wall 1 part, Juncus amplifolius A. Camus 3 parts, Herba Piperris Tonkinensis 2 parts, Calendula officinalis 5 parts, Radix Betae 15 parts, Radix Polygoni hispidi 9 parts, Herba Duchesneae Indicae 0.5 part, Herba Carlinae biebersteinii 1 part, Chinese podophyllum root 6 parts, Bahaba flovolabiata (Lin). 3 parts, Pericarpium Granati 8 parts, Herba Orostachyos 2 parts, Radix Stellariae Yunnanensis 0.7 part, Caulis Seu Folium Euonymi Fortunei 30 parts, Aquilegia viridiflora 6 parts, Folium Rhododendri Micranthi 1.5 parts, Herba Phaenospermatis globosae 1 part, Centropus sinensis (Stephens) 20 parts, Radix seu Herba Gei aleppici 1 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 15 parts, window box oxalis 4 parts, Iresine herbetii 1 part, Flos seu Radix Impatientis nolitangeris 5 parts, Caulis Viburni Macrocephali 3 parts, birch Ye Caulis Viburni Dilatati 2 parts, Herba Chenopodii Hybridi 3 parts.Publication number CN104161268 A(application number 201310202805.X) patent document discloses a kind of Chinese medicine for the treatment of menoxenia, it is made up of the component of following weight portion: Gallus Domesticus 1, pig lean meat 90-110 gram, Radix Rehmanniae Preparata 20-30 gram, Rhizoma Zingiberis Recens 2-4 sheet.

Current treatment the confusion of the menstrual cycle is generally that mainly adjust menstrual cycle with estrogen, progestogen, side effect is large by Western medicine, dependency is strong, causes dose increasing, causes vicious cycle, cause the recurrent exerbation of disease, cause feminine menstrual disorderly further.In recent years, there is multi-medicament in China's Chinese medicine, but effect is all undesirable in treatment the confusion of the menstrual cycle.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, has invigorating the spleen and benefiting QI, nourishing the liver and kidney, heat clearing away regulating menstruation, depressed liver-energy dispersing and QI regulating, effect of blood circulation promoting and blood stasis dispelling.Another object of the present invention is just to provide the preparation method of the Chinese medicine preparation of above-mentioned treatment the confusion of the menstrual cycle.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

The Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, takes off the primary raw material stating weight proportion and is prepared from: Fructus Amomi 15-20 part; Herba Portulacae 10-20 part; Os Sepiae 10-20 part; Semen Myristicae 8-12 part; Fructus Carthami tinctorii 8-15 part; Concha Ostreae 12-20 part; Endothelium Corneum Gigeriae Galli 9-16 part; Radix Polygalae 8-15 part; Pericarpium Citri Reticulatae 10-20 part; Radix Musae 4-9 part; Radix Astragali 15-30 part; Rhizoma Atractylodis Macrocephalae 15-20 part; Pumex 6-10 part; Radix Ophiopogonis 10-20 part.

The Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Fructus Amomi 16-19 part; Herba Portulacae 13-17 part; Os Sepiae 13-17 part; Semen Myristicae 9-11 part; Fructus Carthami tinctorii 10-13 part; Concha Ostreae 15-17 part; Endothelium Corneum Gigeriae Galli 11-14 part; Radix Polygalae 10-13 part; Pericarpium Citri Reticulatae 13-17 part; Radix Musae 5-8 part; Radix Astragali 20-25 part; Rhizoma Atractylodis Macrocephalae 16-19 part; Pumex 7-9 part; Radix Ophiopogonis 13-17 part.

The Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from :fructus Amomi 17 parts; Herba Portulacae 15 parts; Os Sepiae 15 parts; Semen Myristicae 10 parts; Fructus Carthami tinctorii 11 parts; Concha Ostreae 16 parts; Endothelium Corneum Gigeriae Galli 12 parts; Radix Polygalae 12 parts; Pericarpium Citri Reticulatae 15 parts; Radix Musae 6 parts; The Radix Astragali 22 parts; The Rhizoma Atractylodis Macrocephalae 18 parts; Pumex 8 parts; Radix Ophiopogonis 15 parts.

Present invention also offers the preparation method Chinese medicine preparation of above-mentioned treatment the confusion of the menstrual cycle being made pharmaceutically acceptable decoction, capsule, granule, tablet and pill.

The preparation method of the Chinese medicine preparation decoction of described treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.

The preparation method of the Chinese medicine preparation decoction of above-mentioned treatment the confusion of the menstrual cycle, step (4) is moistening 45-55 minute preferably, is more preferably moistening 50 minutes.

Instructions of taking: each 15-20ml, every day 2-3 time, 7 days courses for the treatment of.

The preparation method of the Traditional Chinese medicine preparation capsule of described treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(7) step (6) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.

The preparation method of the Traditional Chinese medicine preparation capsule of above-mentioned treatment the confusion of the menstrual cycle, step (6) is preferably condensed into the thick paste that relative density is 1.13-1.17, is more preferably and is condensed into the thick paste that relative density is 1.15.

Instructions of taking: each 2-3 grain, every day 3 times, 7 days courses for the treatment of.

The preparation method of the Chinese medicine preparation granule of described treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

Instructions of taking: each parcel, every day 2-3 time, 7 days courses for the treatment of.

The preparation method of the Chinese medicine preparation tablet of described treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 7 days courses for the treatment of.

The preparation method of the Chinese medicine preparation pill of described treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder;

(7) by Mel, (consumption of preferred Mel is the 30%-40% of medicated powder quality, the consumption being more preferably Mel is 35% of medicated powder quality) be placed in pot, slow fire is tempered to thick, mix step (6) gained medicated powder, fully mix into ointment thoroughly, pill (preferred diameter is 3mm-5mm, and being more preferably diameter is 4mm) is made by traditional Chinese medical science tradition pill method.

Instructions of taking: each 10-15 ball, every day 3 times, 7 days courses for the treatment of.

Technical advantage of the present invention is mainly reflected in:

1, the present invention treats the principle of Chinese medicine preparation based on Chinese traditional treatment the confusion of the menstrual cycle of the confusion of the menstrual cycle, and each raw material effect is worked in coordination with, and all medicine compatibilities are good to the confusion of the menstrual cycle therapeutic effect.

2, Chinese medicine preparation of the present invention has invigorating the spleen and benefiting QI, nourishing the liver and kidney, heat clearing away regulating menstruation, depressed liver-energy dispersing and QI regulating, effect of blood circulation promoting and blood stasis dispelling.

3, selected materials great majority of the present invention are Chinese medicine material, and crude drug source is extensive, and with low cost, preparation method is simple.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): Fructus Amomi 15 parts; Herba Portulacae 10 parts; Os Sepiae 10 parts; Semen Myristicae 8 parts; Fructus Carthami tinctorii 8 parts; Concha Ostreae 12 parts; Endothelium Corneum Gigeriae Galli 9 parts; Radix Polygalae 8 parts; Pericarpium Citri Reticulatae 10 parts; Radix Musae 4 parts; The Radix Astragali 15 parts; The Rhizoma Atractylodis Macrocephalae 15 parts; Pumex 6 parts; Radix Ophiopogonis 10 parts.

The preparation method of the Chinese medicine preparation decoction of above-mentioned treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, and is calcined to and is popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3 times, merges suspension, leaves standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 120 mesh sieves;

(2) fry the Endothelium Corneum Gigeriae Galli slow fire only made to surface color intensification, spray vinegar (consumption of vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treats that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, and crosses 120 mesh sieves;

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 50 minutes;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.

Instructions of taking: each 20ml, every day 3 times, 7 days courses for the treatment of.

embodiment 2the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, takes off the primary raw material stating weight proportion and is prepared from (every part of 10g): Fructus Amomi 20 parts; Herba Portulacae 20 parts; Os Sepiae 20 parts; Semen Myristicae 12 parts; Fructus Carthami tinctorii 15 parts; Concha Ostreae 20 parts; Endothelium Corneum Gigeriae Galli 16 parts; Radix Polygalae 15 parts; Pericarpium Citri Reticulatae 20 parts; Radix Musae 9 parts; The Radix Astragali 30 parts; The Rhizoma Atractylodis Macrocephalae 20 parts; Pumex 10 parts; Radix Ophiopogonis 20 parts.

The preparation method of the Traditional Chinese medicine preparation capsule of above-mentioned treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, and is calcined to and is popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 4 times, merges suspension, leaves standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 120 mesh sieves;

(2) fry the Endothelium Corneum Gigeriae Galli slow fire only made to surface color intensification, spray vinegar (consumption of vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treats that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, and crosses 120 mesh sieves;

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 50 minutes;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.15(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(7) step (6) gained medicated powder is made capsule by the specification of 0.5g/ grain.

Instructions of taking: each 2-3 grain, every day 3 times, 7 days courses for the treatment of.

model case onepoplar XX, female, 37 years old, people from Tangshan, Hebei Province.Give birth to two daughters, give birth to daughter respectively at when 31 years old, 36 years old.Under birth after middle daughter, occur menoxenia, 15-18 days tides, go through 6-8 days totally, wrap with sanitary towel 3-5.Each menstrual period all can occur: dysmenorrhea, and many through measuring, color is light red, time hold clot under the arm, pale complexion, spiritlessness and weakness, dizzy, soreness of waist pain, tastelessness, indigestion and loss of appetite, frequent urination at night, defecates rotten.Remove hospital admission, be diagnosed as menstrual cycle imbalance, repeatedly take the medicine of regulating menstruation, equal DeGrain.

After taking 2 courses for the treatment of of Traditional Chinese medicine preparation capsule (embodiment 2) of gained of the present invention treatment the confusion of the menstrual cycle, on the occasion of menstrual onset, dysmenorrhea obviously alleviates, and abdominal part just sense of discomfort a little, colporrhagia reduces.Suspend medication after continuing to take 2 courses for the treatment of, until next menstrual onset, cycle stretch-out to 27 day, dysmenorrhea disappears substantially, and menstruation recovers normal substantially.Later stage visits and learns, cycle stability, at 27-28 days, is gone through 4-6 days totally, fully recovered.

embodiment 3the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Fructus Amomi 16 parts; Herba Portulacae 13 parts; Os Sepiae 13 parts; Semen Myristicae 9 parts; Fructus Carthami tinctorii 10 parts; Concha Ostreae 15 parts; Endothelium Corneum Gigeriae Galli 11 parts; Radix Polygalae 10 parts; Pericarpium Citri Reticulatae 13 parts; Radix Musae 5 parts; The Radix Astragali 20 parts; The Rhizoma Atractylodis Macrocephalae 16 parts; Pumex 7 parts; Radix Ophiopogonis 13 parts.

The preparation method of the Chinese medicine preparation granule of above-mentioned treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, and is calcined to and is popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3 times, merges suspension, leaves standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 120 mesh sieves;

(2) fry the Endothelium Corneum Gigeriae Galli slow fire only made to surface color intensification, spray vinegar (consumption of vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treats that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, and crosses 120 mesh sieves;

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 50 minutes;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.15(40 DEG C) thick paste, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

Instructions of taking: each 1 bag, every day 3 times, 7 days courses for the treatment of.

embodiment 4the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Fructus Amomi 19 parts; Herba Portulacae 17 parts; Os Sepiae 17 parts; Semen Myristicae 11 parts; Fructus Carthami tinctorii 13 parts; Concha Ostreae 17 parts; Endothelium Corneum Gigeriae Galli 14 parts; Radix Polygalae 13 parts; Pericarpium Citri Reticulatae 17 parts; Radix Musae 8 parts; The Radix Astragali 25 parts; The Rhizoma Atractylodis Macrocephalae 19 parts; Pumex 9 parts; Radix Ophiopogonis 17 parts.

The preparation method of the Chinese medicine preparation tablet of above-mentioned treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, and is calcined to and is popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 4 times, merges suspension, leaves standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 120 mesh sieves;

(2) fry the Endothelium Corneum Gigeriae Galli slow fire only made to surface color intensification, spray vinegar (consumption of vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treats that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, and crosses 120 mesh sieves;

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 50 minutes;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(6) join in step (5) gained filtrate by step (1)-(2), mixing, being condensed into relative density is 1.15(40 DEG C) thick paste, with fashion of extrusion by 22 eye mesh screens, make single-size, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 7 days courses for the treatment of.

model case twosummer XX, female, 33 years old, people from Baoding, Hebei province.There is polymenorrhea in nearly half a year, a 16-20 day tide, and during each menstrual onset the two or three day, amount is many, and color is dark red, folder clot, at ordinary times profuse leukorrhea, and yellow skin is white, companion's lower abdomen pain, uncomfortable in chest, nausea and vomiting, poor appetite, and yellow urine, defecates rotten, examines as menstrual cycle imbalance.

After taking Chinese medicine preparation tablet (embodiment 4) course for the treatment of more than 1 of gained of the present invention treatment the confusion of the menstrual cycle, occur menstruation climax, amount reduces to some extent, and lower abdomen pain alleviates, and nausea and vomiting phenomenon disappears, continuation medication clean period after 4 days.Continue to take to next menstrual onset, the cycle is 26 days, and menstrual cycle recovers normal substantially, and menstrual blood volume is normal.Later stage visits and learns and fully recover.

embodiment 5the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Fructus Amomi 17 parts; Herba Portulacae 15 parts; Os Sepiae 15 parts; Semen Myristicae 10 parts; Fructus Carthami tinctorii 11 parts; Concha Ostreae 16 parts; Endothelium Corneum Gigeriae Galli 12 parts; Radix Polygalae 12 parts; Pericarpium Citri Reticulatae 15 parts; Radix Musae 6 parts; The Radix Astragali 22 parts; The Rhizoma Atractylodis Macrocephalae 18 parts; Pumex 8 parts; Radix Ophiopogonis 15 parts.

The preparation method of the Chinese medicine preparation pill of above-mentioned treatment the confusion of the menstrual cycle, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, and is calcined to and is popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 4 times, merges suspension, leaves standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 120 mesh sieves;

(2) fry the Endothelium Corneum Gigeriae Galli slow fire only made to surface color intensification, spray vinegar (consumption of vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treats that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, and crosses 120 mesh sieves;

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 50 minutes;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.15(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(7) be placed in pot by Mel (consumption of Mel is 35% of medicated powder quality), slow fire is tempered to thick, mixes step (6) gained medicated powder, fully mixes into ointment thoroughly, makes by the traditional Chinese medical science tradition pill method pill that diameter is 4mm.

Instructions of taking: each 10 balls, every day 3 times, 7 days courses for the treatment of.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Fructus Amomi: acrid in the mouth, warm in nature.Return board, stomach, kidney channel.For the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA.There is removing dampness appetizing, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.

Herba Portulacae: sour in the mouth, cold in nature.Return liver, large intestine channel.For the dry aerial parts of portulacaceous plant Herba Portulacae.There is heat-clearing and toxic substances removing, effect of cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.

Os Sepiae: salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.For the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Containing calcium carbonate more than 85%, in addition, containing methionine, aspartic acid, glutamic acid etc.There is astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, effect of sore.For Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.

Semen Myristicae: pungent, temperature.Return spleen, stomach, large intestine channel.For the myristic dry kernel of myristicaceae plant.Fatty oily 25%-46%, volatile oil 8%-15%, volatile oil master contains sabinene, α-and nopinene, Oleum Pini-4-enol, γ-terpinene, limonene, bornylene, β-phellandrene, to P-cymene, α-terpinolene, alpha-terpineol, δ-cadinene etc.There is warming middle-JIAO to promote flow of QI, effect of relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite is vomitted.

Fructus Carthami tinctorii: sweet in the mouth, hot in nature.For the fruit of feverfew Flos Carthami.Seed oil-containing 30.2%, kernel oil-containing 45-49%, containing linoleic acid 73.6-78.0%, oleic acid 12.0-15.2% in seed oil, and myristic acid, Palmic acid, stearic acid, palmitoleic acid; The kernel deoiled is containing protein 61.5-63.4%.There is promoting blood circulation and detoxication, preventing phlegm from forming and stopping coughing, tonneau intestinal, except Yu Yangxin, effect of dispelling wind for relieving itching.Go out unhappy for pox, the stagnant stomachache of women's vim and vigour stasis of blood, abundant expectoration is coughed, constipation, intestinal angor, depression, cardiopalmus, leprosy, skin pruritus.

Concha Ostreae: salty in the mouth, cold nature.Return liver, gallbladder, kidney channel.For the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating effect.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Endothelium Corneum Gigeriae Galli: sweet in the mouth, property is put down.Return spleen, stomach, small intestinal, urinary bladder channel.For the dry inner wall of sandbag of Phasianidae animal man chicken.There is invigorating the stomach and promoting digestion, effect of arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.

Radix Polygalae: bitter in the mouth, pungent, warm in nature.GUIXIN, kidney, lung meridian.For the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.There is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, effect of detumescence.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

Pericarpium Citri Reticulatae: another name Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, extensively Pericarpium Citri tangerinae etc.Bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.For the dry mature skin of rutaceae orange and variety thereof.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Radix Musae: sweet in the mouth, light, property Great Cold.Return liver, pericardium, urinary bladder channel.For the rhizome of Musaceae plant Musa basjoo Sieb. Et Zucc..Have and relieve heat and thirst, inducing diuresis for treating stranguria syndrome, removing toxic substances, jaundice eliminating, stopping metrorrhagia and leukorrhagia, antiabortive effect.For the capable calentura in sky, unhappy, quench one's thirst, jaundice, edema, beriberi, stranguria with blood, metrorrhagia, leucorrhea, carbuncle, furuncle, erysipelas, wandering erysipelas rash, frequent fetal movement.

The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen channel.For the dry root of leguminous plant Radix Astagali or Radix Astragali.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.For the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive, have loose bowels just clear, frequent fetal movement.

Pumex: salty in the mouth, cold in nature.Return lung, kidney, liver, large intestine channel.Being become by the silicate of aluminum, potassium, sodium, is irregular bulk, not of uniform size, and general diameter 2-7 centimetre, what have reaches 20 centimetres.Rough surface, has the pore that majority differs in size, canescence or lark.Matter is hard and crisp, easily smashes, and section is coarse aperture, some tool spun silk sample gloss or nothing.There is lung heat clearing fire, change old expectorant, relieving stranguria by diuresis, effect of hard masses softening and resolving.For phlegm-heat obstructing in the lung, the thick difficulty of cough with asthma expectorant is coughed up, the puckery pain of dribbling urination, goiter scrofula.

Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.Another name Radix Ophiopogonis is the dried root of liliaceous plant Radix Ophiopogonis.There is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.

test examplein order to verify the curative effect of the Chinese medicine preparation (embodiment 5) of gained of the present invention treatment the confusion of the menstrual cycle, do contrast test in May ,-2012 in August, 2009:

General data: screen 200 routine the confusion of the menstrual cycle patient, wherein minimal ages 19 years old in Duo Jia hospital, max age 49 years old, 34.6 years old mean age; 19-30 year 49 people, 31-40 year 94 people, 41-49 year 57 people.Be divided into experimental group and matched group two groups (wherein experimental group 150 people, matched group 50 people) at random, two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria, possessing following a certain item can be diagnosed as the confusion of the menstrual cycle: 1. advanced menstruation: menstrual cycle is shorter than 21 days, and occurs more than 2 cycles continuously; 2. postpone menstrual period: menstruation misses more than 7 days, even 40-50 days a line, and occur the symptom of more than 2 menstrual cycle continuously; 3. menstruation is successively irregularly, menstruation in advance or postpone, cycle or be shorter than 21 days, or be longer than 35 days.

Usage and dosage: experimental group takes the Chinese medicine preparation pill of gained of the present invention treatment the confusion of the menstrual cycle, each 10 balls, every day 3 times, 7 days courses for the treatment of; Matched group takes other medicine (as WUJI BAIFENG WAN, Zhong Jing thick water circulation etc.), wherein, WUJI BAIFENG WAN: oral, one time 9 grams, 1 time on the one; Or pill is added the molten rear clothes of certain amount of boiling water.Zhong Jing thick water circulation: oral, a 10-20 ball, 2 times on the one.

Criterion of therapeutical effect: recovery from illness: menstruation is made a return journey rule, and the cycle is about 28 days, normal through measuring, menstrual period are moderate, general 4-5 days.Effective: menstrual period, through amount etc. make moderate progress.Invalid: disease is unchanged.

Adopt the matched group of other drug and take the Comparison of therapeutic that gained of the present invention treats the experimental group of the Chinese medicine preparation of the confusion of the menstrual cycle, result is as shown in table 1:

Table 1

As can be seen from Table 1, take the cure rate of the Chinese medicine preparation of gained of the present invention treatment the confusion of the menstrual cycle up to 76.67%, effective percentage is up to 97.33%; And the cure rate taking other drug only 44%, effective percentage also only has 78%, and inefficiency is up to 22%.Can find out: the successful taking the Chinese medicine preparation of gained of the present invention treatment the confusion of the menstrual cycle is better than taking the effect of other drug.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat the Chinese medicine preparation of the confusion of the menstrual cycle, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Fructus Amomi 15-20 part; Herba Portulacae 10-20 part; Os Sepiae 10-20 part; Semen Myristicae 8-12 part; Fructus Carthami tinctorii 8-15 part; Concha Ostreae 12-20 part; Endothelium Corneum Gigeriae Galli 9-16 part; Radix Polygalae 8-15 part; Pericarpium Citri Reticulatae 10-20 part; Radix Musae 4-9 part; Radix Astragali 15-30 part; Rhizoma Atractylodis Macrocephalae 15-20 part; Pumex 6-10 part; Radix Ophiopogonis 10-20 part.

2. the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Fructus Amomi 16-19 part; Herba Portulacae 13-17 part; Os Sepiae 13-17 part; Semen Myristicae 9-11 part; Fructus Carthami tinctorii 10-13 part; Concha Ostreae 15-17 part; Endothelium Corneum Gigeriae Galli 11-14 part; Radix Polygalae 10-13 part; Pericarpium Citri Reticulatae 13-17 part; Radix Musae 5-8 part; Radix Astragali 20-25 part; Rhizoma Atractylodis Macrocephalae 16-19 part; Pumex 7-9 part; Radix Ophiopogonis 13-17 part.

3. the Chinese medicine preparation for the treatment of the confusion of the menstrual cycle according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Fructus Amomi 17 parts; Herba Portulacae 15 parts; Os Sepiae 15 parts; Semen Myristicae 10 parts; Fructus Carthami tinctorii 11 parts; Concha Ostreae 16 parts; Endothelium Corneum Gigeriae Galli 12 parts; Radix Polygalae 12 parts; Pericarpium Citri Reticulatae 15 parts; Radix Musae 6 parts; The Radix Astragali 22 parts; The Rhizoma Atractylodis Macrocephalae 18 parts; Pumex 8 parts; Radix Ophiopogonis 15 parts.

4., according to the Chinese medicine preparation of the arbitrary described treatment the confusion of the menstrual cycle of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute;

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) gains are joined in step (5) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.

5. the Chinese medicine preparation decoction preparation method for the treatment of the confusion of the menstrual cycle according to claim 4, is characterized in that: step (4) is moistening 45-55 minute preferably, is more preferably moistening 50 minutes.

6., according to the Chinese medicine preparation of the arbitrary described treatment the confusion of the menstrual cycle of claim 1-3, it is characterized in that, the preparation method of described capsule, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(7) step (6) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.

7. the preparation method of the Traditional Chinese medicine preparation capsule for the treatment of the confusion of the menstrual cycle according to claim 6, is characterized in that: step (6) is preferably condensed into the thick paste that relative density is 1.13-1.17, is more preferably and is condensed into the thick paste that relative density is 1.15.

8., according to the Chinese medicine preparation of the arbitrary described treatment the confusion of the menstrual cycle of claim 1-3, it is characterized in that, the preparation method of described granule, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

9., according to the Chinese medicine preparation of the arbitrary described treatment the confusion of the menstrual cycle of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.

10., according to the Chinese medicine preparation of the arbitrary described treatment the confusion of the menstrual cycle of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:

(1) Os Sepiae, Concha Ostreae are pounded into fritter with Pumex, mix homogeneously, intense fire heats, be calcined to and be popular in, be poured into water leaching immediately and quench, stir, incline and get suspension in upper water, residue continues to forge to be quenched 3-4 time, merges suspension, leave standstill, treat that upper strata clear water is removed in clarification hypsokinesis, dry, pulverize, cross 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(2) the Endothelium Corneum Gigeriae Galli slow fire only made stir-fry is deepened to surface color, (consumption of preferred vinegar is the 8%-12% of Endothelium Corneum Gigeriae Galli quality to spray vinegar, the consumption being more preferably vinegar is 10% of Endothelium Corneum Gigeriae Galli quality), treat that vinegar is by complete inspiration Endothelium Corneum Gigeriae Galli, dry, pulverize, excessively 100-140 mesh sieve (preferred 110-130 mesh sieve excessively, was more preferably 120 mesh sieves);

(3) humus flava usta is ground into fine powder, is placed in pot, moderate heat is heated to soil in flexible state, adds the Radix Polygalae of section, and stir-fry to medical surfaces and evenly hang up one deck soil powder, and when appearing fragrance, take out, sieve removes native powder, cools;

(4) by Radix Musae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and section Radix Ophiopogonis, be placed in glass container, pour rice wine into, mix thoroughly, add Fructus Amomi Flos Carthami, moistening 40-60 minute (preferred moistening 45-55 minute is more preferably moistening 50 minutes);

(5) Herba Portulacae, Semen Myristicae and Pericarpium Citri Reticulatae are placed in marmite, soak half an hour, add step (3)-(4) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(6) step (1)-(2) are joined in step (5) gained filtrate, mixing, being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17, be more preferably and be condensed into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder;

(7) by Mel, (consumption of preferred Mel is the 30%-40% of medicated powder quality, the consumption being more preferably Mel is 35% of medicated powder quality) be placed in pot, slow fire is tempered to thick, mix step (6) gained medicated powder, fully mix into ointment thoroughly, pill (preferred diameter is 3mm-5mm, and being more preferably diameter is 4mm) is made by traditional Chinese medical science tradition pill method.