CN104663585B - Food toad return of spring worm breeding method and obtained pharmaceutical raw material - Google Patents

Abstract

Food toad return of spring worm breeding method and obtained pharmaceutical raw material.Current medical market constantly increases to toad maggot and its product demand, it is ensured that the toad maggot product with bioactivity simultaneously can form industrialization.The present invention comprises the following steps：Cultivate base fly；Toad is put into and is removed contamination except dirty dose, moved about 48 hours；Described removing contamination except the toad in dirty dose is pulled out and be put into and lure fly to produce maggot prescription, immersion is travelling 24 hours；Pull out immersion after toad with rubber hammer into shape each and every one hit unconsciously after, by the toad after described immersion be put into product maggot incubator in preserve；Barrenwort liquid glucose is sprayed to the toad body surface face in described product maggot incubator, the existence of base fly is put into after squirting educates fly room, is laid eggs by base fly, produce full children maggot after one hour on toad body；Allow young maggot to eat toad, and educate fly indoor growing；Obtain fresh and alive maggot；Collect net maggot；Dry maggot：By low-temperature air-drying baking oven, dry maggot；Storage.The present invention is for cultivating food toad return of spring worm.

Description

Food toad return of spring worm breeding method and obtained pharmaceutical raw material

Technical field：

The present invention relates to one kind food toad return of spring worm breeding method and obtained pharmaceutical raw material.

Background technology：

Food toad return of spring worm is toad maggot, and toad is commonly called as toad, is the traditional precious medicinal animal of China.From Gu So far, a medicine proverb is spread in medical field：" the not raw maggot of toad, raw maggot is exactly precious." because toad maggot has magical medicine medicine Reason is acted on, and it can treat various difficult and complicated cases for being difficult to and curing.Early in before more than 300 years, Li Shizhen (1518-1593 A.D.) is at it《Compendium of Materia Medica》In it is right The unique medical value of toad maggot, magical curative effect had clearly to be recorded in detail（Volume 42）.In the last hundred years, due to mountain Woods, farmland, rivers and creeks etc. are changed by pollution in various degree, destruction, natural environment.People are difficult to collect natural toad maggot Worm, for treating disease, in the course of time, the medical value of toad maggot treating disease is gradually indifferent.Past gathers toad maggot, is Stepped on to die by livestock in toad, wild animal kills, the toad maggot that the toad corpse of postmortem putrefaction grows is beaten by people, measures less.It is difficult to Meet demand medically.

Cancer brings heavy financial burden and mental burden to patient, especially some cancers middle and advanced stage patient, existing Some medical procedures cannot effectively be treated to it.Annual about 80,000,000,000 yuans of left sides of drug expenditure for being used for cancer patient It is right.Medical market demand is good effect, acts on the characteristic such as faster, but with to normal cell without killing destruction.Toad Bufonid toad maggot will turn into the ideal medicament simply for the treatment of tumour.

According to investigations, medical toad maggot prepares paste, suppository, inuncts to external curing ox-hide in national drug in some provinces Tinea, lupus, hemorrhoid, anal fistula, gangrene and gynaecologic vaginal, cervicitis, rotten to the corn good results.

Current medical market both at home and abroad constantly increases to toad maggot and its product demand, it is ensured that living with natural biology The toad maggot product of property simultaneously can form industrialization.Always current insoluble problem both at home and abroad.

During toad maggot culture, lure the process of fly product maggot particularly important, however, lure the cultivation of fly at present having very Difficulty high, the formula for luring fly product maggot to use can directly affect the cultivation and growth of toad maggot.

During toad maggot culture, remove contamination except dirty process is particularly important, however, being capable of body only currently without one kind Remove contamination except dirty dose, removing contamination except dirty process, the dirt of toad body can not reach thoroughly removing.

Exist into January, 2013《China's tumour registration annual report in 2012》Externally issue：" whole nation just has one in annual 6 minutes People is diagnosed as cancer, has 8550 people to turn into cancer patient daily, just has a people to die from cancer in every 7 ~ 8 people." " Nattonal Cancer Morbidity form is severe, and incidence and mortality is in continue ascendant trend, annual new cancer cases about 3,500,000, because of cancer mortality About 2,500,000.”

The content of the invention：

It is an object of the invention to provide one kind food toad return of spring worm breeding method.

Above-mentioned purpose is realized by following technical scheme：

Food toad return of spring worm breeding method, the method comprises the following steps：

（1）Cultivate base fly；

（2）Toad is put into and is removed contamination except dirty dose, moved about 48 hours；

（3）Described removing contamination except the toad in dirty dose is pulled out and be put into and lure fly to produce maggot prescription, immersion is travelling 24 hours；

（4）Pull out immersion after toad with rubber hammer into shape each and every one hit unconsciously after, by the toad after described immersion be put into product maggot training Support preservation in case；

（5）Barrenwort liquid glucose is sprayed to the toad body surface face in described product maggot incubator, the existence of base fly is put into after squirting Fly room is educated, is laid eggs by base fly, produce full children maggot after one hour on toad body；

（6）Allow young maggot to eat toad, and educate fly indoor growing；

（7）Obtain fresh and alive maggot；

（8）Collect net maggot；

（9）Dry maggot：By low-temperature air-drying baking oven, dry maggot；

（10）Storage.

Described food toad return of spring worm breeding method, described described step（1）It is middle cultivate base fly method be：

（1）Take dead fish or dead shrimp places stand-by in container；

（2）Fly will be lured to produce maggot prescription 2Kg, after the 5Kg that adds water boils 45 minutes, the timing since after boiling adds clear water 5kg to stir Mix rear waste and take juice, be obtained and lure fly to produce maggot concoction；

（3）Described to lure fly to produce maggot concoction to pour into container, the described dead fish of immersion or dead shrimp be after one hour, described Dead fish or dead shrimp are pulled out and minced with knife, spray barrenwort liquid glucose；

（4）The base fly room of base fly existence is put into, young maggot is produced by base fly, base fly of new generation is broken pupa and goes out after eight days, after ten days Older generation base fly dies gradually, and new base fly is educating the existence of fly room after cultivation, and is multiplied from generation to generation in fly room educating.

Described food toad return of spring worm breeding method, described step（6）In to allow the edible toad in young maggot pond be producing full children maggot Incubator lay out culturing rack, mark correct time, in six days maggot toad eat everything up, only surplus small part toad spine, receives Maggot, receives maggot and must not exceed 7.

Described food toad return of spring worm breeding method, described step（7）In be to obtain fresh and alive maggot；Maggot is combined in and is put In the net maggot sieve of good wheat bran skin, maggot wriggles to reach and is castrated in wheat bran skin, weeds out wheat bran skin and is left fresh and alive maggot.

Described food toad return of spring worm breeding method, described step（8）In to collect net maggot be that maggot is poured into temperature not surpass Stirred in the frying pan for crossing 70 DEG C, cause maggot to scald dead, weed out the grains of sand, collect net maggot；

Described food toad return of spring worm breeding method, described step（10）Middle one bag of per kilogram of storage, is put into refrigerator-freezer zero In lower 3~5 DEG C, preserve for a long time stand-by.

Described food toad return of spring worm breeding method, the described preparation method for luring fly to produce maggot prescription：Take 290 ~ 310g of mushroom, 290 ~ 310g of pawpaw, beet are done 290 ~ 310g, 290 ~ 310g of hedgehog hydnum, the 9.5 ~ 11kg that adds water and are decocted 28 ~ 32 minutes, are opened from after boiling Beginning timing, after taking slag, plus 38 ~ 42kg of clear water, that is, food toad return of spring worm cultivation is obtained lures fly product maggot prescription.

Described food toad return of spring worm breeding method, it is described to remove contamination except dirty dose of preparation method, take CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 200g, the dried immature fruit of citron orange 200g, saltcake 50g, rheum officinale 80g add water 5kg decoct 30 minutes, the timing since after boiling, after taking slag, add clear water 40~ 50kg, that is, be obtained toad maggot cultivation and remove contamination except dirty dose.

Described food toad return of spring worm breeding method, described barrenwort liquid glucose includes barrenwort, sugar, described barrenwort, The ratio of sugar is 1:0.3.

The medicine prepared using the method for one of claim 1-9, its composition is included：Fly worm, it is characterized in that：Using right It is required that the method for 1-9 is made, anti-cancer medicament raw material is used as.

Beneficial effect：

1. the present invention lure fly produce maggot prescription mushroom it is sweet, it is mild-natured, containing lentinan, vitamin, fat, protein and Inorganic salts, it is adaptable to which patient immune function is low, can be eaten as the food nutrition therapy of tumor patient；Pawpaw taste Sweet, cold, containing carbohydrate, tartaric acid, malic acid, tartaric acid, multivitamin and various enzymes, wherein papain can divide Solution protein is amino acid, another fatty oily 25%, gastric indigestion, intestinal parasitic disease can be treated；Beet is sweet mild-natured, contains Amino acid, still containing oleanolic acid, glycine betaine, flavonoids and sucrose etc., have functions that help is promoted the production of body fluid, purify the blood cool blood, for controlling Treat leukaemia；Hericium erinaceus is sweet mild-natured, nourishing and fit keeping function, relieving the five internal organs, supports taste, containing polysaccharides and polypeptide, can improve lymph thin Born of the same parents' Transform Law, lifting leucocyte enhancing immune function of human body.

This four traditional Chinese medicine, is all the product of nourishing, containing abundant carbohydrate, tartaric acid, protein, amino acid, has both allowed toad to be swum in immersion Nutrition is absorbed in dynamic, systemic activity material, maggot to be raised is enriched.Four traditional Chinese medicine liquid is also that fly is liked inhaling fair juice, to criticizing Amount is cultivated toad and is played a decisive role.

The present invention removes contamination except dirty dose of CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China：Bitter temperature, it is warm in nature, have the effect of lower gas eliminating dampness and dissipate full；The dried immature fruit of citron orange：Bitter is acid It is slightly cold, the broken product effect of the promoting the circulation of qi that eliminates indigestion and phlegm；Saltcake：Taste saltiness is cold clearing away heat and purging, the work(of softening mass and moistening dryness；Rheum officinale：Bitter, property It is cold, there is removing intestines sthenia gastropyrexia to gather, enteron aisle is dredged, knot is removed in defaecation.CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China, the dried immature fruit of citron orange, saltcake, rheum officinale are used in combination, can Make toad in immersion is travelling, remove external mud, tongue, dirt and reach net body.Remove that internal dyspepsia phlegm is stagnant, place dyspepsia is dirty, clearly Except the unclean miscellaneous dirt of remaining in stomach.Ensure the base-material toad as culture food toad maggot, crust is pure and fresh, and the five internal organs are penetrating, without corruption it is dirty, Germ influences the pharmaceutical quality of toad maggot.

The present invention cultivates base fly room：12 ㎡, room lid is glass steel tile, and door double-layer seal, surrounding or both sides windowpane are studded with Screen window, makes cross-ventilation.It is required that：Warm moisturizing is inhaled, is become clear, air circulation.

Barrenwort liquid glucose of the invention is spraying external application side, barrenwort：Acrid-sweet flavor, it is warm in nature to play the role of tonifying kidney and strengthening yang.It is Sexual function is improved, benefit controls the key medicine of impotence due to deficiency of the kidney.This medicine is configured to spray compared with sucrose, does lure, to gathering the same of fly When promote fly mating farrowing to produce immeasurable effect.

It is of the invention to lure fly product maggot prescription mushroom of the invention sweet, it is mild-natured, containing lentinan, vitamin, fat, albumen Matter and inorganic salts, it is adaptable to which patient immune function is low, can be eaten as the food nutrition therapy of tumor patient；Pawpaw Sweet, cold, containing carbohydrate, tartaric acid, malic acid, tartaric acid, multivitamin and various enzymes, wherein papain can be with Decomposing protein is amino acid, another fatty oily 25%, gastric indigestion, intestinal parasitic disease can be treated；Beet is sweet mild-natured, Containing amino acid, still containing oleanolic acid, glycine betaine, flavonoids and sucrose etc., have functions that help is promoted the production of body fluid, purify the blood cool blood, be used for Treatment leukaemia；Hericium erinaceus is sweet mild-natured, nourishing and fit keeping function, relieving the five internal organs, supports taste, containing polysaccharides and polypeptide, can improve lymph Cell transformation is restrained, lifting leucocyte enhancing immune function of human body.

The product that mushroom, pawpaw, beet are dry, hedgehog hydnum is all nourishing, containing abundant carbohydrate, tartaric acid, protein, amino acid, both allowed Toad absorbs nutrition in immersion is travelling, enriches systemic activity material, maggot to be raised.Four traditional Chinese medicine liquid is also that fly is liked inhaling fair Juice, to batch cultivate toad play a decisive role.

Various medicines produce biological respinse, resulting maggot body tool in certain circumstances in toad body and in maggot body There is significant anticancer medical value.

The present invention can produce 1kg maggots per 35kg toads（Dry product）Production base can produce 5 months every year（South）Can give birth to Produce dry maggot 500kg.

The medical expert in Japan and Korea S., West Europe and the U.S. starts to study toad maggot pharmacology composition in recent years.Through Primary Study Pass through itself local behavior metabolism distinctive medicinal component in itself in analysis toad maggot body：Such as 17 kinds of amino necessary to the mankind Sour, various trace elements：Calcium, phosphorus, copper, germanium, selenium, zinc, manganese etc..Above all it contains：

（1）Pure natural agglutinin：There are extremely strong anticancer, antibacterial, anti-virus ability, have extremely strong to tumour cell and cancer cell Inhibitory action.And quickly promote wound, skin ulcer quickly to heal, analgesic hemostatic it is rapid.

（2）Pure natural chitin：Penetration is extremely strong, the various bacterial viruses that can quickly clear up in subcutaneous hair follicle tissue, soft Change blood vessel.The effect of reaching skin care, beautifying face and moistering lotion and brighten.

（3）Japanses beauty-berry：It is the elite of Chinese medicine, anti-inflammatory analgetic, convergence skin, the special effect driven away the five poisonous creatures: scorpion, viper, centipede, house lizard, toad, kill bacterium.

（4）Bioprotein：It is the essential nutriment of human body, cell viability can be strengthened, improves body immunity.

（5）Antimicrobial active protein：Not only to G（+）Coccus has killing action, and also has effect to bacillus.

（6）Cell membrane, reducing blood lipid can be also protected containing phosphatide, SOD simultaneously, cardiovascular and cerebrovascular diseases, anti-ageing work of waiting for a long time is prevented and treated With.

（7）My company sets up standardized toad maggot cultivation flow and teaching and research by Northeast Agricultural University's bio-pharmaceuticals Room is analyzed and has been separated to its active ingredient, has obtained the effective antitumor composition of high-purity.Simultaneously also to the effective ingredient Cytologic experiment is carried out, as a result shows that toad maggot effective ingredient can in vitro suppress tumour growth.

Specific embodiment：

Embodiment 1：

One kind food toad return of spring worm breeding method, it is characterized in that：The method comprises the following steps：

（1）Cultivate base fly；

（2）Toad is put into and is removed contamination except dirty dose, moved about 48 hours；

（3）Described removing contamination except the toad in dirty dose is pulled out and be put into and lure fly to produce maggot prescription, immersion is travelling 24 hours；

（4）Pull out immersion after toad with rubber hammer into shape each and every one hit unconsciously after, by the toad after described immersion be put into product maggot training Support preservation in case；

（5）Barrenwort liquid glucose is sprayed to the toad body surface face in described product maggot incubator, the existence of base fly is put into after squirting Fly room is educated, is laid eggs by base fly, produce full children maggot after one hour on toad body；

（6）Allow young maggot to eat toad, and educate fly indoor growing；

（7）Obtain fresh and alive maggot；

（8）Collect net maggot；

（9）Dry maggot：By low-temperature air-drying baking oven, dry maggot；

（10）Storage.

Embodiment 2：

Food toad return of spring worm breeding method according to embodiment 1, described described step（1）The middle side for cultivating base fly Method is：

（1）Take dead fish or dead shrimp places stand-by in container；

（2）Fly will be lured to produce maggot prescription 2Kg, after the 5Kg that adds water boils 45 minutes, the timing since after boiling adds clear water 5kg to stir Mix rear waste and take juice, be obtained and lure fly to produce maggot concoction；

（3）Described to lure fly to produce maggot concoction to pour into container, the described dead fish of immersion or dead shrimp be after one hour, described Dead fish or dead shrimp are pulled out and minced with knife, spray barrenwort liquid glucose；

（4）The base fly room of base fly existence is put into, young maggot is produced by base fly, base fly of new generation is broken pupa and goes out after eight days, after ten days Older generation base fly dies gradually, and new base fly is educating the existence of fly room after cultivation, and is multiplied from generation to generation in fly room educating.

Embodiment 3：

Food toad return of spring worm breeding method according to embodiment 1, described step（6）In allow the edible toad in young maggot pond to be The incubator for producing full children maggot is laid out culturing rack, correct time is marked, in six days maggot toad eat everything up, only surplus small part During toad spine, maggot is received, the receipts maggot time must not exceed 7 days the latest.

Embodiment 4：

Food toad return of spring worm breeding method according to embodiment 1, described step（7）In be to obtain fresh and alive maggot； Maggot is combined in put well wheat bran skin net maggot sieve in, maggot wriggles to reach and is castrated in wheat bran skin, weed out wheat bran skin be left it is fresh and alive Maggot；

Embodiment 5：

Food toad return of spring worm breeding method according to embodiment 1, described step（8）In to collect net maggot be that maggot is fallen Enter during Sha Wen is no more than 70 DEG C of frying pan and stir, cause maggot to scald dead, weeds out the grains of sand, collect net maggot；

Embodiment 6：

Food toad return of spring worm breeding method according to embodiment 1, described step（10）Middle one bag of per kilogram of storage, puts Entering refrigerator-freezer can for a long time preserve stand-by in subzero 3~5 DEG C.

Embodiment 7：

Food toad return of spring worm breeding method according to embodiment 1, the described preparation method for luring fly to produce maggot prescription：Take perfume (or spice) 290 ~ 310g of mushroom, 290 ~ 310g of pawpaw, beet do 290 ~ 310g, 290 ~ 310g of hedgehog hydnum, the 9.5 ~ 11kg that adds water and decoct 28 ~ 32 points Clock, the timing since after boiling, after taking slag, plus 38 ~ 42kg of clear water, that is, food toad return of spring worm cultivation is obtained lures fly product maggot prescription.

Embodiment 8：

Food toad return of spring worm breeding method according to embodiment 7, mushroom 300g, pawpaw 300g, beet do 600g, monkey Head 300g, the 10kg that adds water are decocted 30 minutes, after taking slag, plus clear water 40kg, toad in removing dirty dose is pulled out and is put into concoction, soak It is travelling 24 hours.

Embodiment 9：

Food toad return of spring worm breeding method according to embodiment 1, it is described to remove contamination except dirty dose of preparation method, take river thick Plain 200g, dried immature fruit of citron orange 200g, saltcake 50g, rheum officinale 80g add water 5kg decoct 30 minutes, the timing since after boiling, after taking slag, add 40~50kg of clear water, that is, be obtained toad maggot cultivation and remove contamination except dirty dose.

Embodiment 10：

The breeding method of base fly in food toad return of spring worm cultivation according to embodiment 1, described barrenwort liquid glucose includes Barrenwort, sugar, described barrenwort, the ratio of sugar are 1:0.3.

Claims (3)

1. it is a kind of to eat toad return of spring worm breeding method, it is characterized in that：The method comprises the following steps：

（1）Cultivate base fly；

（2）Toad is put into and is removed contamination except dirty dose, moved about 48 hours；

（3）Described removing contamination except the toad in dirty dose is pulled out and be put into and lure fly to produce maggot prescription, immersion is travelling 24 hours；

（4）Pull out immersion after toad with rubber hammer into shape each and every one hit unconsciously after, by the toad after described immersion be put into product maggot incubator Middle preservation；

（5）Barrenwort liquid glucose is sprayed to the toad body surface face in described product maggot incubator, the existence of base fly is put into after squirting educates fly Room, is laid eggs by base fly, produces full children maggot after one hour on toad body；

（6）Allow young maggot to eat toad, and educate fly indoor growing；

（7）Obtain fresh and alive maggot；

（8）Collect net maggot；

（9）Dry maggot：By low-temperature air-drying baking oven, dry maggot；

（10）Storage；

Described step（1）It is middle cultivate base fly method be：

（1）Take dead fish or dead shrimp places stand-by in container；

（2）Fly will be lured to produce maggot prescription 2Kg, after the 5Kg that adds water boils 45 minutes, the timing since after boiling adds clear water 5kg to stir Mix rear waste and take juice, be obtained and lure fly to produce maggot concoction；

（3）Described to lure fly to produce maggot concoction to pour into container, the described dead fish of immersion or dead shrimp be after one hour, described dead fish Or dead shrimp is pulled out and minced with knife, barrenwort liquid glucose is sprayed；

（4）The base fly room of base fly existence is put into, young maggot is produced by base fly, base fly of new generation is broken pupa and goes out after eight days, old one after ten days Die gradually for base fly, new base fly is educating the existence of fly room after cultivation, and is multiplied from generation to generation in fly room educating；

Described step（6）In to allow the edible toad in young maggot pond be that the incubator for producing full children maggot is laid out culturing rack, when marking accurate Between, in six days maggot toad eat everything up, only surplus small part toad spine, receives maggot, receive maggot and must not exceed 7；

Described step（7）In be to obtain fresh and alive maggot；Maggot is combined in put well wheat bran skin net maggot sieve in, maggot is in wheat bran Wriggle to reach in skin and be castrated, weed out wheat bran skin and be left fresh and alive maggot；

Described step（8）In to collect net maggot be that maggot is poured into temperature no more than being stirred in 70 DEG C of frying pan, cause maggot to scald dead, The grains of sand are weeded out, net maggot is collected；

Described step（10）Middle one bag of per kilogram of storage, is put into refrigerator-freezer in subzero 3~5 DEG C, preserves for a long time stand-by.

2. the food toad return of spring worm breeding method according to claim 1, it is characterized in that：The described system for luring fly to produce maggot prescription Make method：Take 290 ~ 310g of mushroom, 290 ~ 310g of pawpaw, beet dry 290 ~ 310g, 290 ~ 310g of hedgehog hydnum, add water 9.5 ~ 11kg Decoct 28 ~ 32 minutes, the timing since after boiling, after taking slag, plus 38 ~ 42kg of clear water, that is, luring for food toad return of spring worm cultivation is obtained Fly produces maggot prescription；

It is described to remove contamination except dirty dose of preparation method, take CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 200g, dried immature fruit of citron orange 200g, saltcake 50g, rheum officinale 80g and add water 5kg Decoct 30 minutes, the timing since after boiling, after taking slag, add 40~50kg of clear water, that is, toad maggot cultivation is obtained and removes contamination Except dirty dose.

Described barrenwort liquid glucose includes barrenwort, sugar, and described barrenwort, the ratio of sugar are 1:0.3.

3. the medicine that prepared by a kind of method of one of utilization claim 1-2, its composition includes：Fly worm, it is characterized in that：Utilize The method of claim 1-2 is made, and itself local behavior metabolism distinctive medicinal component in itself is passed through in toad maggot body, respectively Plant medicine and produce biological respinse in toad body and in maggot body in certain circumstances, resulting maggot body has significant anti- Cancer medical value, is used as anti-cancer medicament raw material.