CN104524132A - Efficient medicine composition for treating chapped skin and preparation method thereof - Google Patents

Abstract

The invention provides an efficient medicine composition for treating chapped skin and a preparation method thereof. The medicine composition accords with the principle of traditional Chinese medicine combination, firstly, alangium leaf, eriocarpous glochidion leaf, garcinia mangostana, conespike flemingia leaf, lead, gypsum, borneol and dragon blood are taken as monarch and minister drugs fundamentally to promote tissue regeneration, inhibit bacteria and relieve pain and itching, and are used for playing key roles in promoting growth of skin cells; loofah, cucumber, Chinese toona juice, camellia oil, sesame oil, Chinese rose flower, peony, lily, field bindweed, orange peel and towel gourd flower are taken as assistant drugs to play roles in coordinating and strengthening the treatment functions of monarch drugs and minister drugs and restraining toxic and side effects of other drugs; the loofah and the cucumber have the effect supplying moisture, so that dry and tight skin can be relieved; and Chinese rose flower, peony, lily, field bindweed, orange peel and towel gourd flower can be used for improving the fragrance of finished medicine products and have the effects of cooling, removing toxicity, diminishing inflammation and protecting skin.

Description

The active drug composition and method of making the same for the treatment of chapped skin

Technical field

The present invention relates to medicine and pharmacology technical field, specifically a kind of active drug composition and method of making the same for the treatment of chapped skin.

Background technology

Chapped skin refers to the hand and foot xerosis cutis and crackle that are caused by a variety of causes, and with pain, severe patient can affect daily life and work.Primary disease is some dermopathic simultaneous phenomenons, is also one independently dermatosis.Rhagadia manus et pedis is apt to occur in autumn and winter season.Erythra is distributed in the position referring to bend side, palm, heel, cuticle thickening or the often friction such as outside the sufficient sole of the foot, clinical manifestation is along the depth of dermatoglyph development, crack different in size, from without any, skin lesion can feel that slight twinge or moderate are touched a tender spot, and even causalgia with hemorrhage.

But it is little for chapped skin curative drug at present, majority be write skin care skin care item as glycerol, or other are cold creams of skin moisturizing, and therapeutic effect is also all general, take effect slow, some chemical composition contains hormone medicine, easily recurrence after curing, and therefore also to need to study a kind of therapeutic effect remarkable in market, instant effect, have no side effect, non-stimulated, a kind of active drug composition and method of making the same being used for the treatment of chapped skin do not recurred.

Summary of the invention

The invention provides a kind of active drug composition and method of making the same for the treatment of chapped skin, medicine of the present invention meets the principle of drug matching, first fundamentally start with, with Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis is the medicine of the monarch and his subjects, flesh engendering antibacterial, antalgesic-antipruritic, pivotal role promotes the growth of Skin Cell, with Fructus Luffae, Fructus Cucumidis sativi, Sucus Toonae sinensis, Camellia oil, Oleum Sesami, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, the medicine of Flos Luffae for assisting a ruler in governing a country, play coordinative role, strengthen the treatment function of monarch drug and ministerial drug, the toxic and side effects of restriction other drug, Fructus Luffae and Fructus Cucumidis sativi have effect of moisturizing to skin, decrease the drying of skin, tension, the fragrance that Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae not only improve pharmaceutical product also has the effect of refreshing and detoxicating, antiinflammatory skin protection.

These material combination make each efficacy of drugs produce synergism, giving consideration to both the incidental and fundamental, medication is gentle, thus can effectively treat chapped skin dermatosis, and the present invention can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, focus of going directly, healing time is short, not easily recurs after healing.

The active drug compositions for the treatment of chapped skin, is characterized in that: be made up of the raw material of following weight portion:

Folium Alangii 40-50 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 40-50 part, Cortex Garciniae 40-50 part, Folium Flemingiae bracteatae 40-50 part, Plumbum preparatium 30-40 part, Gypsum Fibrosum 30-40 part, Borneolum Syntheticum 30-40 part, Sanguis Draxonis 30-40 part, Fructus Luffae 40-50 part, Fructus Cucumidis sativi 40-50 part, Sucus Toonae sinensis 20-30 part, Camellia oil 20-30 part, Oleum Sesami 20-30 part, Flos Rosae Chinensis 20-30 part, Flos Moutan 20-30 part, Flos Lilii viriduli 20-30 part, Herba seu Flos Convolvuli arvensis 20-30 part, Citrus pericarp 20-30 part, Flos Luffae 20-30 part.

The active drug compositions for the treatment of chapped skin, is characterized in that: be made up of the raw material of following weight portion:

Folium Alangii 42-48 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 42-48 part, Cortex Garciniae 42-48 part, Folium Flemingiae bracteatae 42-48 part, Plumbum preparatium 32-38 part, Gypsum Fibrosum 32-38 part, Borneolum Syntheticum 32-38 part, Sanguis Draxonis 32-38 part, Fructus Luffae 42-48 part, Fructus Cucumidis sativi 42-48 part, Sucus Toonae sinensis 22-28 part, Camellia oil 22-28 part, Oleum Sesami 22-28 part, Flos Rosae Chinensis 22-28 part, Flos Moutan 22-28 part, Flos Lilii viriduli 22-28 part, Herba seu Flos Convolvuli arvensis 22-28 part, Citrus pericarp 22-28 part, Flos Luffae 22-28 part.

The active drug compositions for the treatment of chapped skin, is characterized in that: be made up of the raw material of following weight portion:

Folium Alangii 45 parts, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 45 parts, Cortex Garciniae 45 parts, Folium Flemingiae bracteatae 45 parts, Plumbum preparatium 35 parts, 35 parts, Gypsum Fibrosum, Borneolum Syntheticum 35 parts, Sanguis Draxonis 35 parts, 45 parts, Fructus Luffae, Fructus Cucumidis sativi 45 parts, Sucus Toonae sinensis 25 parts, Camellia oil 25 parts, 25 parts, Oleum Sesami, Flos Rosae Chinensis 25 parts, Flos Moutan 25 parts, Flos Lilii viriduli 25 parts, Herba seu Flos Convolvuli arvensis 25 parts, Citrus pericarp 25 parts, Flos Luffae 25 parts.

The active drug compositions for the treatment of chapped skin, is characterized in that: the dosage form of described compositions is unguentum, distilled medicinal water agent, medicine oil liniment.

The preparation method of the active drug compositions for the treatment of chapped skin, is characterized in that: when the dosage form of described compositions is unguentum, be specially:

(1) Folium Alangii is got by formula proportion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Fructus Luffae, Fructus Cucumidis sativi, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, the each component drug of Flos Luffae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use,

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to that 300-400 order fine powder and the ointment of stand for standby use in preparation method (1) add Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology unguentum of the present invention.

The preparation method of the active drug compositions for the treatment of chapped skin, is characterized in that: when the dosage form of described compositions is distilled medicinal water agent, be specially:

(1) get Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Fructus Luffae, Fructus Cucumidis sativi and distilled water by formula proportion to be mixed into according to a certain percentage in distillator, fire boils, steam is utilized to carry out by stronger plant fragrance quintessence oil, make it to form the vapor phase containing quintessence oil, through process for cooling, utilize temp-difference condensing to become liquid condition, thus it is for subsequent use to isolate dew;

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to 300-400 order fine powder and be separated in preparation method (1) that dew for subsequent use adds Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology distilled medicinal water agent of the present invention.

The preparation method of the active drug compositions for the treatment of chapped skin, is characterized in that: when the dosage form of described compositions is medicine oil liniment, be specially:

By formula proportion by each Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, the each component drug of Sanguis Draxonis is pulverized respectively, add Fructus Luffae in proportion, Fructus Cucumidis sativi mixes, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, Sucus Toonae sinensis is added after heating micro-boiling 15 minutes, Camellia oil, Oleum Sesami, cooling after continuing to be heated to seethe with excitement, filter, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtain medicine of the present invention oil liniment.

Present invention also offers a kind of unguentum being used for the treatment of chapped skin, the crude drug of described unguentum comprises Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis, Sucus Toonae sinensis, Camellia oil, Oleum Sesami, Fructus Luffae, Fructus Cucumidis sativi.

Present invention also offers a kind of medicine oil liniment being used for the treatment of chapped skin, the crude drug of described medicine oil liniment comprises Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis, Sucus Toonae sinensis, Camellia oil, Oleum Sesami, Fructus Luffae, Fructus Cucumidis sativi.

Present invention also offers a kind of distilled medicinal water agent being used for the treatment of chapped skin, the crude drug of described distilled medicinal water agent comprises Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis, Sucus Toonae sinensis, Camellia oil, Oleum Sesami, Fructus Luffae, Fructus Cucumidis sativi.

beneficial effect of the present invention:

Formula of the present invention is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, with low cost, and abnormal smells from the patient delicate fragrance is easy to be accepted by patient.The present invention makes chapped skin position focus be subject to optimal stimulation, flesh engendering antibacterial, antalgesic-antipruritic, promotes unblocked blood flowing, gives the moisture of skin abundance, and nourish skin, reach strengthening vital QI to eliminate pathogenic factors effect, clinical efficacy is excellent.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and focus of going directly, healing time is short, not easily recurs after healing.

the property of medicine and the pharmacology of medicine selected by the present invention are respectively:

Folium Alangii:

[meridian distribution of property and flavor] is pungent bitter flat return liver kidney channel

[function cures mainly] removing toxic substances and promoting subsidence of swelling blood-activating analgetic traumatic injury congestive edema fracture skin ulcer swells acute mastitis cracked nipple dermatitis rhus scabies the arthroncus of knee traumatic hemorrhage

Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi):

[meridian distribution of property and flavor] bitter but sweet flavor is puckery, and property is put down;

[effect] dispelling wind and dampness, dissipating blood stasis, hemostasis, detumescence.Cure mainly acute gastroenteritis, dysentery, rheumatic arthritis, traumatic injury, wound hemorrhage, dermatitis rhus, eczema, dermatitis; Control Toxicodendron verniciflnum (Stokes) F. A. Barkley (Rhus verniciflua Stokes) allergy, paddy field property dermatitis, skin pruritus, exfoliative dermatitis, urticaria, eczema: the fresh leaf of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) or cured leaf, decoction being used as a lotion.

Cortex Garciniae:

Return through hardship puckery cool

function cures mainly anti-inflammatory analgetic convergence granulation promoting for enteritis infantile dyspepsia stomach duodenal ulcer peptic Ulcers hyporrhea stomatitis periodontitis burn and scald is controlled in external ulcer of the lower limb eczema

Folium Flemingiae bracteatae:

function cures mainly control wound decoct washing. wound is not easily suppurated promote promoting tissue regeneration and wound healing

Flos Rosae Chinensis:

[meridian distribution of property and flavor] sweet in the mouth, warm in nature, enter Liver Channel.

[function cures mainly] has effect of promoting blood flow to regulate menstruation, subduing swelling and detoxicating.Because the blood stasis dispelling of Flos Rosae Chinensis, circulation of qi promoting, analgesic effect are obvious, therefore be often used to disease such as treatment menoxenia, dysmenorrhea etc., there is amenorrhea in women or menstruation is thin, color is light and amount less, lower abdominal pain, have the smooth and constipation due to dry stool of spirit etc. concurrently, or there is above-mentioned symptom in menstrual phase, good with victory spring soup therapeutic effect.

Flos Moutan:

Paeonia suffruticosa not only has ornamental value, but also has very high medical value.Being processed into " Cortex Moutan " by the root of Paeonia suffruticosa, is famous and precious Chinese herbal medicine.Its cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warp, have dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition, effect of anti-inflammation, clothes can be lengthened the life by beneficial body for a long time.Nourish blood regulating liver-QI, loose strongly fragrant blood stasis dispelling, is applicable to chloasma faciei, skin aging, and normal drink QI and blood is lived lung, and appearance is ruddy, improves menoxenia, dysmenorrhea, only sweating due to debility, night sweat.

Flos Lilii viriduli:

[nature and flavor] Bulbus Lilii sweet in the mouth, cold nature; GUIXIN, lung meridian.

[function cures mainly] nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Have nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN, sputum mixed with blood, as all sorts of flowers cream.Control chronic cough of deficiency lung, chronic cough is spat blood, as baihe gujin decoction.Have clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep etc.

Herba seu Flos Convolvuli arvensis:

[nature and flavor] are pungent; Temperature; Poisonous; Return kidney channel.

[function cures mainly] dispelling wind for relieving itching; Pain relieving.Main air pain of dampness syndrome; Toothache; Neurodermatitis.

Citrus pericarp:

Pericarpium Citri Reticulatae, gives out golden yellow clear bright peel, except fragrant sour-sweet taste, also has one simple and elegant flowery odour, can promote appetite, skin maintenance, minimizing feeling of fatigue.Sweet strongly fragrant fruital, is applicable to drinking together with other flowers and plants very much.

Mandarin orange is nutritious and one of maximum fruit of consumption figure.Pulp flavor is splendid, and juice sweet taste is beautiful, also often makes popular drink.Can be made into confection and fruit jelly etc. after Pericarpium Citri Reticulatae processing, is the traditional Chinese medical science conventional " Pericarpium Citri Reticulatae " after drying; Blade, flower and fruit can refine quintessence oil, perfume.Marc and peel also can obtain through refining pectin and aromatic oil Pericarpium Citri Reticulatae brews up, and can utilize that Pericarpium Citri Reticulatae alleviating distention in middle-JIAO is regulated the flow of vital energy, effect of stopping coughing and removing phlegm, and Pericarpium Citri Reticulatae bubble green tea, can reduce phlegm and internal heat and separate expectorant, anti-inflammation, therefore cough ant phlegm person drink is useful.

Flos Luffae:

[nature and flavor] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, sweet and slightly bitter taste."

[function cures mainly] heat-clearing and toxic substances removing.Control cough due to lung-heat, pharyngalgia, sinusitis, furuncle, hemorrhoid.

Fructus Luffae:

[meridian distribution of property and flavor] sweet in the mouth, cool in nature, enter liver, stomach warp,

[function] has the effects such as clearing away summer-heat removing heat from blood, removing toxic substances relieving constipation, dispelling pathogenic wind and eliminating phlegm, the beauty treatment of profit flesh, the meridian dredging, promoting the circulation of blood arteries and veins, lower milk, regulating menstruation have some setbacks, and can also be used for the treatment of calentura fever of the body excessive thirst, the disease such as phlegm dyspnea cough, hemorrhoidal hamorrhage anal fistula, metrorrhagia, leukorrhagia, stranguria with blood, treatment carbuncle sore swell, women's agalactia.Containing the vitamin B group preventing skin aging in Fructus Luffae, the compositions such as the vitamin C of skin whitening, can protect skin, eliminate speckle, making skin pure white, delicate, is rare cosmetic good merchantable brand, therefore the title of Sucus Luffae " beauty's water ".Ms eats Fructus Luffae more and also has some setbacks to regulating menstruation helpful.

Plumbum preparatium:

[nature and flavor] are pungent, salty, are slightly cold.Poisonous.

[function cures mainly] removing toxic substances and promoting tissue regeneration, sore.Sore swollen toxin is controlled in external, wound hemorrhage, burn and scald.

Gypsum Fibrosum:

[meridian distribution of property and flavor] Xin Gan, cold.1. " herbal classic ": " acrid in the mouth is slightly cold." 2. " not Lu ": " sweet, Great Cold, nontoxic." 3. " medicine origin ": " and " curing mainly secret formula " cloud, cold in nature, lightly seasoned." enter lung, stomach warp.1. Materia Medica of Decoction: " lunar, few sun of starting with, Foot yangming Channel." 2. " Amplification on Materia Medica addendum ": " enter that sun is bright, hands is lunar, the few sun of hands.”

[function cures mainly] is controlled calentura high fever and is not moved back, vexed coma, and delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, and hyperactivity of toxic heat, sends out speckle dermexanthesis, aphtha of the mouth and tongue.Outer in order to heat clearing away sore, granulation promoting.Forge deposited promoting tissue regeneration and ulcer healing.External treatment ulcer sores, bursts and does not close up, the burning hot wound of soup.Efficacy of drugs: expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, heat-clearing and toxic substances removing.

Borneolum Syntheticum:

[meridian distribution of property and flavor] acrid in the mouth, hardship, be slightly cold; GUIXIN, spleen, lung hydrocarbon.

[function] has one's ideas straightened out refreshment, clearing away heat to alleviate pain.

ancient books is made a summary

1. " Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, and deaf, improving eyesight, goes conjunctival congestion skin nebula.”

2. Compendium of Material Medica: " treatment sore throat, headache, nose Xi, toothache, typhoid fever protrusion of the tongue, children's's pox fall into.Logical all keys, loose stagnated fire.”

3. " medical center bun want ": " Borneolum Syntheticum master falls apart stagnated fire, can deep heat, controls infantile convulsion, expectorant fan, sore throat, and swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not keep, also can granulation promoting pain relieving ^[1].So loose and easily exhaust, be that YIN-cold is also after all.”

Sanguis Draxonis:

[meridian distribution of property and flavor] is sweet salty, flat.Enter the heart, liver, spleen channel.

[effect] takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.

[curing mainly]

1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.

2. lump in the abdomen mass in the abdomen, breast ventral spine pain.

3. traumatic injury, congestion swells and ache.

4. traumatic hemorrhage, ulcer being unable to heal.

Sucus Toonae sinensis:

[medical material Ji Yuan]

For the juice that Meliaceae plant Chinese toon tree master stream goes out.

[return through]lung meridian.

[effect]profit bath removing toxic substances; Sensible.

[curing mainly]snore is sick; Rhagadia manus et pedis; Furuncle.

Camellia oil:

Camellia oil (having another name called Oleum camelliae, Oleum Camelliae, camellia seed oil) takes from the seed of tea oil tree.The manufacturing process of Camellia oil can be divided into: shell, dry, and pulverizes, oil expression, and filter, overall process is physical method, and therefore it is real fully natural green edible oil.Not containing erucic acid in Oleum Camelliae, cholesterol, flavacin and other additive.After tested: in Oleum Camelliae, unsaturated fatty acid is up to more than 90%, oleic acid reaches 80-83%, and linoleic acid reaches 7-13%, and rich in proteins and vitamin A, B, D, E etc., the abundant linolenic acid especially contained by it is needed by human and can not synthesizes.Through scientific verification, the oleic acid of Camellia oil and linoleic acid content are all higher than olive oil.

Ming Dynasty's medicine scholar Li Shizhen (1518-1593 A.D.) mentions the dietary function of Oleum Camelliae in Compendium of Material Medica: " camellia oleosa seed, bitter cold cure mainly dyspnea with rapid respiration cough, remove expectorant dirt." also how on the books in other ancient books, " detailed outline is picked up any lost article from the road " record " Oleum Camelliae can treat hemorrhoid, moves back damp and hot " " agriculture occupies diet spectrum " record " Oleum Camelliae cooking sumptuous courses at a meal, daily all suitable, cooking food, there is light in pool, all oil only this most clearly, therefore all diseases are not avoided." record that " Oleum Camelliae is cooler, cooling blood for hemostasis, heat-clearing and toxic substances removing in highly skilled doctor's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica.Cure mainly liver blood loss, anthelmintic.Benefit the intestines and stomach, improving eyesight " cloud " camellia oleosa seed again.

Oleum Camelliae energy uvioresistant, prevents sunburn and reduces wrinkle, very effective to chloasma, sunburn.Oleum Camelliae contains abundant natural Vitamin E, tea polyphenols, Squalene.These all possess effect of beautifying and anti-aging.

Satisfied fatty acid in the food such as the fish that people often uses, meat, egg, milk, reaches and suppresses fat, the function of prevention three-hypers, and unsaturated fatty acid cries again beauty treatment acid, ediblely can make the skin smooth of people for a long time, moisten.

Oleum Sesami:

Chinese medicine is thought: this product nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.Record according in Compendium of Material Medica: " have moisturize, detoxify, pain relieving, detumescence merit." " not Lu " say: " sharp large intestine, afterbirth does not fall.Survivor's lump of rubbing swells, raw alopecia.”

[function cures mainly] for oral administration can intestine moistening, lung moistening; Be used as ointment machin plaster substrate outward; Outer application, as scald, burn, skin ulcer etc., with Oleum Sesami and (mixing) medicine (powdery), applies in affected part, and do not do and do not split, good is fast.Clinically also decoct plaster with Oleum Sesami, have granulation promoting meat, the effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.Containing sesamin in linum, when with siritch parch or bake dish or food, sesamin can decomposite the compound of Semen Sesami acid and some fragrance, and these fragrance matters can volatilize at normal temperatures, its aromatic flavor, elegant, tempting appetite are that other similar vegetable oil all hardly match.But the too high environment of temperature can cause the volatilization of fragrance, therefore, siritch should be placed in cryopreservation.

Fructus Cucumidis sativi:

[nature and flavor] sweet in the mouth; Cool in nature.

[return through] returns lung; Spleen; Stomach warp.

[function cures mainly] heat clearing away; Diuretic; Removing toxic substances.Main calentura is thirsty; Oliguria with reddish urine; Edema oliguria; Burn due to hot liquid or fire; Tinea versicolor; Non-skin ulcer.

detailed description of the invention:

embodiment 1, formula:

Folium Alangii 40mg, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 40mg, Cortex Garciniae 40mg, Folium Flemingiae bracteatae 40mg, Plumbum preparatium 30mg, Gypsum Fibrosum 30mg, Borneolum Syntheticum 30mg, Sanguis Draxonis 30mg, Fructus Luffae 40mg, Fructus Cucumidis sativi 40mg, Sucus Toonae sinensis 20mg, Camellia oil 20mg, Oleum Sesami 20mg, Flos Rosae Chinensis 20mg, Flos Moutan 20mg, Flos Lilii viriduli 20mg, Herba seu Flos Convolvuli arvensis 20mg, Citrus pericarp 20mg, Flos Luffae 20mg;

When the dosage form of compositions is unguentum, preparation method is specially:

(1) Folium Alangii is got by formula proportion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Fructus Luffae, Fructus Cucumidis sativi, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, the each component drug of Flos Luffae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use,

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to that 300-400 order fine powder and the ointment of stand for standby use in preparation method (1) add Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology unguentum of the present invention.

embodiment 2, formula:

Folium Alangii 42mg, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 42mg, Cortex Garciniae 42mg, Folium Flemingiae bracteatae 42mg, Plumbum preparatium 32mg, Gypsum Fibrosum 32mg, Borneolum Syntheticum 32mg, Sanguis Draxonis 32mg, Fructus Luffae 42mg, Fructus Cucumidis sativi 42mg, Sucus Toonae sinensis 22mg, Camellia oil 22mg, Oleum Sesami 22mg, Flos Rosae Chinensis 22mg, Flos Moutan 22mg, Flos Lilii viriduli 22mg, Herba seu Flos Convolvuli arvensis 22mg, Citrus pericarp 22mg, Flos Luffae 22mg;

Preparation method is specially:

When the dosage form of described compositions is unguentum, be specially:

(1) Folium Alangii is got by formula proportion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Fructus Luffae, Fructus Cucumidis sativi, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, the each component drug of Flos Luffae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use,

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to that 300-400 order fine powder and the ointment of stand for standby use in preparation method (1) add Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology unguentum of the present invention.

embodiment 3, formula:

Folium Alangii 45mg, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 45mg, Cortex Garciniae 45mg, Folium Flemingiae bracteatae 45mg, Plumbum preparatium 35mg, Gypsum Fibrosum 35mg, Borneolum Syntheticum 35mg, Sanguis Draxonis 35mg, Fructus Luffae 45mg, Fructus Cucumidis sativi 45mg, Sucus Toonae sinensis 25mg, Camellia oil 25mg, Oleum Sesami 25mg, Flos Rosae Chinensis 25mg, Flos Moutan 25mg, Flos Lilii viriduli 25mg, Herba seu Flos Convolvuli arvensis 25 parts, Citrus pericarp 25mg, Flos Luffae 25mg.

When the dosage form of described compositions is distilled medicinal water agent, preparation method is specially:

(1) get Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Fructus Luffae, Fructus Cucumidis sativi and distilled water by formula proportion to be mixed into according to a certain percentage in distillator, fire boils, steam is utilized to carry out by stronger plant fragrance quintessence oil, make it to form the vapor phase containing quintessence oil, through process for cooling, utilize temp-difference condensing to become liquid condition, thus it is for subsequent use to isolate dew;

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to 300-400 order fine powder and be separated in preparation method (1) that dew for subsequent use adds Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology distilled medicinal water agent of the present invention.

embodiment 4, formula:

Folium Alangii 48mg, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 48mg, Cortex Garciniae 48mg, Folium Flemingiae bracteatae 48mg, Plumbum preparatium 38mg, Gypsum Fibrosum 38mg, Borneolum Syntheticum 38mg, Sanguis Draxonis 38mg, Fructus Luffae 48mg, Fructus Cucumidis sativi 48mg, Sucus Toonae sinensis 28mg, Camellia oil 28mg, Oleum Sesami 28mg, Flos Rosae Chinensis 28mg, Flos Moutan 28mg, Flos Lilii viriduli 28mg, Herba seu Flos Convolvuli arvensis 28mg, Citrus pericarp 28mg, Flos Luffae 28mg;

When the dosage form of compositions is distilled medicinal water agent, preparation method is specially:

(1) get Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Fructus Luffae, Fructus Cucumidis sativi and distilled water by formula proportion to be mixed into according to a certain percentage in distillator, fire boils, steam is utilized to carry out by stronger plant fragrance quintessence oil, make it to form the vapor phase containing quintessence oil, through process for cooling, utilize temp-difference condensing to become liquid condition, thus it is for subsequent use to isolate dew;

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to 300-400 order fine powder and be separated in preparation method (1) that dew for subsequent use adds Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology distilled medicinal water agent of the present invention.

embodiment 5, formula:

Folium Alangii 50mg, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 50mg, Cortex Garciniae 50mg, Folium Flemingiae bracteatae 50mg, Plumbum preparatium 40mg, Gypsum Fibrosum 40mg, Borneolum Syntheticum 40mg, Sanguis Draxonis 40mg, Fructus Luffae 50mg, Fructus Cucumidis sativi 50mg, Sucus Toonae sinensis 30mg, Camellia oil 30mg, Oleum Sesami 30mg, Flos Rosae Chinensis 30mg, Flos Moutan 30mg, Flos Lilii viriduli 30mg, Herba seu Flos Convolvuli arvensis 30mg, Citrus pericarp 30mg, Flos Luffae 30mg;

When the dosage form of compositions is medicine oil liniment, preparation method is specially:

By formula proportion by each Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, the each component drug of Sanguis Draxonis is pulverized respectively, add Fructus Luffae in proportion, Fructus Cucumidis sativi mixes, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, Sucus Toonae sinensis is added after heating micro-boiling 15 minutes, Camellia oil, Oleum Sesami, cooling after continuing to be heated to seethe with excitement, filter, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtain medicine of the present invention oil liniment.

acute toxicity testing data

1, experimental technique

Depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory returns cage to observe 24 hours, often organize Cavia porcellus and be coated with unguentum 0.2,0.4 of the present invention and 0.8ml respectively, medicine oil liniment 0.2,0.4 of the present invention and 0.8ml, distilled medicinal water agent 0.2,0.4 of the present invention and 0.8ml, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.

Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.

long term toxicity test data

1, experimental technique

random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 20 square centimeters of losing hair or feathers.Clean depilatory, observe and often organize Cavia porcellus after 24 hours and be coated with unguentum 0.2,0.4 of the present invention and 0.8ml respectively, medicine oil liniment 0.2,0.4 of the present invention and 0.8ml, distilled medicinal water agent 0.2,0.4 of the present invention and 0.8ml, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.

Prompting, medicine long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.

aggregate toxicity is tested:

Medicine of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

clinical data

patient's physical data

Patient is all from 2010-2014 the department of dermatologry patients in the court, and totally 105 is routine.Wherein man 62 example, female 43 example, all meets the diagnostic criteria of chapped skin disease.At random patient is divided into 2 groups: matched group and treatment group, treatment group 55 example, matched group 50 example, acquisition and recording patient physical data and state of an illness data after being admitted to hospital, adopts APACHE II standards of grading assess patient severity extent.Two groups of patient data and APACHE II mark more equal no significant difference (P > 0. 05).

diagnostic criteria

According to the clinical characters of skin lesion, namely diagnosable, carry out Mycology examination, antibacterial culturing and patch test if desired.

standards of Chinese Medical Syndrome Differentiation

With reference to Education in TCM Higher Institutions textbook " Diagnostics of Chinese Medicine " all genus outer pathogenies, many rules such as employing determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs or differentiation of syndromes according to pathogeneses of QI and blood etc.Therefore dermopathic integral syndrome differentiation, must, according to its whole body syndrome, adopt above-mentioned rule to conclude respectively, and in this, as the Main Basis of rounded analysis.

Meet the diagnostic criteria of above chapped skin disease dermatosis, Standards of Chinese Medical Syndrome Differentiation and signature Informed Consent Form person simultaneously and get rid of following factors for including this research case in.

exclusion standard

(1) malignant tumor; (2) systemic lupus erythematosus (sle); (3) age is less than 10 years old; (4) anemia of pregnant woman or women breast-feeding their children; (5) spiritedness history of disease person; (6) be reluctant participate in test or mismatch therapist.

therapeutic Method

Matched group: with glycerol.Dosage: 200mg, 3 times/day.

Treatment group: smear the external used medicine in the embodiment of the present invention on the basis for the treatment of of control group scheme, dosage: 200mg, 3 times/day, the totally 10 days course for the treatment of.

observation index

Observe the change of the patient skin colour of skin every day, the change of skin at chapped skin position, and the change of other sings and symptomses.

efficacy assessment standard and result

efficacy assessment standard

Recovery from illness: above all observation index full recoveries are normal; Effective: the state of an illness is clearly better; Effective: sb.'s illness took a favorable turn but not obvious; Invalid: the state of an illness has no and takes a turn for the better or increase the weight of, and observation index is without being clearly better or increasing the weight of.

result

Two groups of general curative effects compare, and the results are shown in Table 1.

A table 1 liang group general curative effect compares [example (%)]

Group	n	Cure	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	55	14(25.5)	23(41.8)	12(21.8)	6(10.9)	49(89.1)
Matched group	50	8(16.0)	17(34.0)	15(30.0)	10(20.0)	40(80.0)

As can be seen from Table 1, adopt the overall treatment effect that Drug therapy chapped skin disease of the present invention can be improved, treatment group, compared with matched group, has comparability.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat the active drug compositions of chapped skin, it is characterized in that: the raw material of described compositions comprises: Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis, Fructus Luffae, Fructus Cucumidis sativi, Sucus Toonae sinensis, Camellia oil, Oleum Sesami, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae.

2. the active drug compositions for the treatment of chapped skin according to claim 1, is characterized in that: be made up of the raw material of following weight portion:

Folium Alangii 40-50 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 40-50 part, Cortex Garciniae 40-50 part, Folium Flemingiae bracteatae 40-50 part, Plumbum preparatium 30-40 part, Gypsum Fibrosum 30-40 part, Borneolum Syntheticum 30-40 part, Sanguis Draxonis 30-40 part, Fructus Luffae 40-50 part, Fructus Cucumidis sativi 40-50 part, Sucus Toonae sinensis 20-30 part, Camellia oil 20-30 part, Oleum Sesami 20-30 part, Flos Rosae Chinensis 20-30 part, Flos Moutan 20-30 part, Flos Lilii viriduli 20-30 part, Herba seu Flos Convolvuli arvensis 20-30 part, Citrus pericarp 20-30 part, Flos Luffae 20-30 part.

3. the active drug compositions for the treatment of chapped skin according to claim 1 and 2, is characterized in that: be made up of the raw material of following weight portion:

Folium Alangii 42-48 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 42-48 part, Cortex Garciniae 42-48 part, Folium Flemingiae bracteatae 42-48 part, Plumbum preparatium 32-38 part, Gypsum Fibrosum 32-38 part, Borneolum Syntheticum 32-38 part, Sanguis Draxonis 32-38 part, Fructus Luffae 42-48 part, Fructus Cucumidis sativi 42-48 part, Sucus Toonae sinensis 22-28 part, Camellia oil 22-28 part, Oleum Sesami 22-28 part, Flos Rosae Chinensis 22-28 part, Flos Moutan 22-28 part, Flos Lilii viriduli 22-28 part, Herba seu Flos Convolvuli arvensis 22-28 part, Citrus pericarp 22-28 part, Flos Luffae 22-28 part.

4. the active drug compositions of the treatment chapped skin according to claims 1 to 3 any one, is characterized in that: be made up of the raw material of following weight portion:

Folium Alangii 45 parts, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 45 parts, Cortex Garciniae 45 parts, Folium Flemingiae bracteatae 45 parts, Plumbum preparatium 35 parts, 35 parts, Gypsum Fibrosum, Borneolum Syntheticum 35 parts, Sanguis Draxonis 35 parts, 45 parts, Fructus Luffae, Fructus Cucumidis sativi 45 parts, Sucus Toonae sinensis 25 parts, Camellia oil 25 parts, 25 parts, Oleum Sesami, Flos Rosae Chinensis 25 parts, Flos Moutan 25 parts, Flos Lilii viriduli 25 parts, Herba seu Flos Convolvuli arvensis 25 parts, Citrus pericarp 25 parts, Flos Luffae 25 parts.

5. the active drug compositions of the treatment chapped skin according to Claims 1-4 any one, is characterized in that: the dosage form of described compositions is unguentum, distilled medicinal water agent, medicine oil liniment.

6. the preparation method of the active drug compositions of the treatment chapped skin according to claim 1 to 5 any one, is characterized in that: when the dosage form of described compositions is unguentum, be specially:

(1) Folium Alangii is got by formula proportion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Fructus Luffae, Fructus Cucumidis sativi, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, the each component drug of Flos Luffae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use,

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to that 300-400 order fine powder and the ointment of stand for standby use in preparation method (1) add Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology unguentum of the present invention.

7. the preparation method of the active drug compositions of the treatment chapped skin according to claim 1 to 5 any one, is characterized in that: when the dosage form of described compositions is distilled medicinal water agent, be specially:

(1) get Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Fructus Luffae, Fructus Cucumidis sativi and distilled water by formula proportion to be mixed into according to a certain percentage in distillator, fire boils, steam is utilized to carry out by stronger plant fragrance quintessence oil, make it to form the vapor phase containing quintessence oil, through process for cooling, utilize temp-difference condensing to become liquid condition, thus it is for subsequent use to isolate dew;

(2) get Plumbum preparatium by formula proportion, Gypsum Fibrosum, Borneolum Syntheticum, Sanguis Draxonis be ground to 300-400 order fine powder and be separated in preparation method (1) that dew for subsequent use adds Sucus Toonae sinensis, Camellia oil, Oleum Sesami stir after mixing, then through cold preservation, pressing, sterilization packaging technology distilled medicinal water agent of the present invention.

8. the preparation method of the active drug compositions of the treatment chapped skin according to claim 1 to 5 any one, is characterized in that: when the dosage form of described compositions is medicine oil liniment, be specially:

By formula proportion by each Folium Alangii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Cortex Garciniae, Folium Flemingiae bracteatae, Flos Rosae Chinensis, Flos Moutan, Flos Lilii viriduli, Herba seu Flos Convolvuli arvensis, Citrus pericarp, Flos Luffae, Plumbum preparatium, Gypsum Fibrosum, Borneolum Syntheticum, the each component drug of Sanguis Draxonis is pulverized respectively, add Fructus Luffae in proportion, Fructus Cucumidis sativi mixes, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, Sucus Toonae sinensis is added after heating micro-boiling 15 minutes, Camellia oil, Oleum Sesami, cooling after continuing to be heated to seethe with excitement, filter, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtain medicine of the present invention oil liniment.