CN104523884A - Effective component composition of traditional Chinese medicines for treating habitual abortion and preparation method of composition - Google Patents

Effective component composition of traditional Chinese medicines for treating habitual abortion and preparation method of composition Download PDF

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Publication number
CN104523884A
CN104523884A CN201410816893.7A CN201410816893A CN104523884A CN 104523884 A CN104523884 A CN 104523884A CN 201410816893 A CN201410816893 A CN 201410816893A CN 104523884 A CN104523884 A CN 104523884A
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composition
habitual abortion
chinese medicinal
part composition
preparation
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Pending
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CN201410816893.7A
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Chinese (zh)
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张群
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张群
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Priority to CN201410816893.7A priority Critical patent/CN104523884A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

Abstract

The invention discloses an effective component composition of traditional Chinese medicines for treating habitual abortion and a preparation method of the composition. The effective component composition of the traditional Chinese medicines is prepared from the following raw materials according to certain parts by weight: common sage herb, climbing groundsel herb, mock-strawberry, abrus cantoniensis hance, folium photiniae and pine nodular branch. The effective component composition of traditional Chinese medicines disclosed by the invention can be prepared into a medicine for treating habitual abortion, and the composition has the effects of benefiting qi and nourishing blood, strengthening essence and preventing miscarriage, and enriching yin and nourishing kidney; the composition can be used for significantly treating the habitual abortion, and the composition has the advantages of being free from toxic and side effects and high in safety.

Description

A kind of Chinese medicinal effective-part composition being used for the treatment of habitual abortion and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition being used for the treatment of habitual abortion and preparation method thereof.
Background technology
Habitual abortion, refer to women conceived continuous 2 this or more spontaneous abortion person.Mostly within 4 ~ 10 weeks, occur in gestation, be characterized in that each miscarriage often occurs in same gestation month.Clinical symptoms is with colporrhagia, and few abdomen pendant pain and flank pain are main, are a kind of diseases of the comparatively common refractory again of gynecological.Primary disease is many because of luteal phase defect, hypothyroidism, and the reasons such as congenital uterus or dysplasia of cervix cause.In recent years more find there is substantial connection with chromosomal abnormality.The Therapeutic Method that current shortage is desirable, doctor trained in Western medicine majority uses hormone medicine, but have some to affect unavoidably on fetus.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal effective-part composition for the preparation for the treatment of habitual abortion, this Chinese medicinal effective-part composition can treat habitual abortion fast and effectively, has the advantage that therapeutic effect is remarkable, safety is high, have no side effect.
Another object of the present invention is the preparation method providing above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
In theory of Chinese medical science, the cause of disease of primary disease mostly is ferritic weakness, and deficiency of kidney-QI or yin asthenia generating intrinsic heat cause.In addition also careless with pregnant rear daily life, feelings will is uncomfortable relevant, causes feotus vitality to lose and supports.
The Chinese medicinal effective-part composition for the treatment of habitual abortion of the present invention is made up of the following raw material according to mass fraction meter: Herba Salviae Plebeiae 21, Herba Senecionis Scandentis 21, Herba Duchesneae Indicae 21, Herba Abri 21, Folium Photiniae (Folium Photiniae serrulatae) 8 and Lignum Pini Nodi 8.
The dosage form that the Chinese medicinal effective-part composition that the present invention treats habitual abortion is applicable to processing is oral liquid.
The preparation method of the Chinese medicinal effective-part composition for the treatment of habitual abortion of the present invention comprises the steps:
(1) each Chinese medicinal components is pulverized, add 18 times of water gagings, decoct 3 times, each decoction 1 hour; Merging filtrate after filtration decocting liquid, is evaporated to the cream that relative concentration is 1.2, adds ethanol, make its alcohol content be 70%, hold over night, reclaims ethanol, concentrated;
(2) by the concentrated solution after concentrated conveniently preparation process add applicable adjuvant, processing oral liquid.
Compared with prior art, the present invention has following beneficial effect:
(1) compositions of the present invention there is benefiting QI and nourishing blood, solid in effects of antiabortive, enriching yin and nourishing kidney, through test, can fast treating habitual abortion.
(2) present composition has no side effect.
(3) preparation method of the present composition is simple, and yield is high, effectively maintains the effective ingredient of medicine.
Detailed description of the invention
Explain the present invention further below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
embodiment 1
Get Herba Salviae Plebeiae 21g, Herba Senecionis Scandentis 21g, Herba Duchesneae Indicae 21g, Herba Abri 21g, Folium Photiniae (Folium Photiniae serrulatae) 8g and Lignum Pini Nodi 8g, be crushed to coarse powder, add 18 times of water gagings, decoct 3 times, each decoction 1 hour; Merging filtrate after filtration decocting liquid, is evaporated to the cream that relative concentration is 1.2, adds ethanol, make its alcohol content be 70%, hold over night, reclaim ethanol, obtain concentrated solution 1000ml, get simple syrup, add above-mentioned concentrated solution, and adjust pH to 5 with citric acid, adding distil water is to 5000ml, stir, be distributed into after fine straining in 15ml vial, be packaged to be oral liquid.
This product is brown clear liquid, places in half a year and does not produce muddiness, pH about 5, total solid about 9%.
embodiment 2
Clinical observation patient 1000 example, patient all has obvious habitual abortion clinical symptoms and makes a definite diagnosis through clinicist.
The oral liquid that oral embodiment 1 is obtained, every day 1 time, each 15ml.Administration time is 20 days.
After 20 days, the patient census of embodiment 1 gained oral liquid is used to the results are shown in Table 1.
Criterion of therapeutical effect: effective referring to works as time gestation continuation until childbirth, and ultrasound diagnosis fetal development is normal.Invalid is embryo's stasi, miscarriage.
Table 1
Number of cases Effective Invalid Obvious effective rate (%)
1000 1000 0 100
Known by table 1, the oral liquid that embodiment 1 obtains has specially good effect at treatment habitual abortion.After oral liquid made by Chinese medicine of the present invention, can in 20 days the healing of highly significant or relieving habitual abortion.
embodiment 3
Use the oral liquid administration ICR mice that embodiment 1 is obtained, body weight 30 ~ 35g, mice is conceived female Mus, successive administration 90d.
Through prerun, the lotion toxicity that embodiment 1 obtains is very low, does not measure LD50, therefore carries out maximum dosage-feeding mensuration on the one to mice.Maximum dosage-feeding is 150ml/d, observes none example and be poisoned to death after 90 days, all healthy survival, and female Mus produces all smoothly, proves that the oral liquid that compositions of the present invention is made can not cause toxic and side effects to human body thus.

Claims (4)

1. treat a Chinese medicinal effective-part composition for habitual abortion, it is characterized in that being made up of the following raw material according to mass fraction meter: Herba Salviae Plebeiae 21, Herba Senecionis Scandentis 21, Herba Duchesneae Indicae 21, Herba Abri 21, Folium Photiniae (Folium Photiniae serrulatae) 8 and Lignum Pini Nodi 8.
2. the Chinese medicinal effective-part composition for the treatment of habitual abortion according to claim 1, is characterized in that described Chinese medicinal effective-part composition makes oral liquid.
3. treat the preparation method of the Chinese medicinal effective-part composition of habitual abortion described in claim 1 or 2, it is characterized in that comprising the steps:
(1) each Chinese medicinal components is pulverized, add 18 times of water gagings, decoct 3 times, each decoction 1 hour; Merging filtrate after filtration decocting liquid, is evaporated to the cream that relative concentration is 1.2, adds ethanol, make its alcohol content be 70%, hold over night, reclaims ethanol, concentrated;
(2) by the concentrated solution after concentrated conveniently preparation process add applicable adjuvant, processing oral liquid.
4. the application of Chinese medicinal effective-part composition described in claim 1 or 2, is characterized in that the medicine of described Chinese medicinal effective-part composition for the preparation for the treatment of habitual abortion.
CN201410816893.7A 2014-12-25 2014-12-25 Effective component composition of traditional Chinese medicines for treating habitual abortion and preparation method of composition Pending CN104523884A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410816893.7A CN104523884A (en) 2014-12-25 2014-12-25 Effective component composition of traditional Chinese medicines for treating habitual abortion and preparation method of composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410816893.7A CN104523884A (en) 2014-12-25 2014-12-25 Effective component composition of traditional Chinese medicines for treating habitual abortion and preparation method of composition

Publications (1)

Publication Number Publication Date
CN104523884A true CN104523884A (en) 2015-04-22

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ID=52839640

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Application Number Title Priority Date Filing Date
CN201410816893.7A Pending CN104523884A (en) 2014-12-25 2014-12-25 Effective component composition of traditional Chinese medicines for treating habitual abortion and preparation method of composition

Country Status (1)

Country Link
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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
徐淑敏: "中医药治疗习惯性流产的临床经验", 《中医临床研究》 *
胡红: "固肾清热法治疗胎动不安 80 例", 《中国中医药科技》 *

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Application publication date: 20150422