CN104523860A - Liver calming and yang suppressing preparation for treating hypertension complicated with fullness in head and preparation method of liver calming and yang suppressing preparation - Google Patents

Liver calming and yang suppressing preparation for treating hypertension complicated with fullness in head and preparation method of liver calming and yang suppressing preparation Download PDF

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CN104523860A
CN104523860A CN201410813188.1A CN201410813188A CN104523860A CN 104523860 A CN104523860 A CN 104523860A CN 201410813188 A CN201410813188 A CN 201410813188A CN 104523860 A CN104523860 A CN 104523860A
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dry
radix
take out
fullness
preparation
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刘保祥
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Abstract

The invention discloses a liver calming and yang suppressing preparation for treating hypertension complicated with fullness in head. The liver calming and yang suppressing preparation is mainly prepared from the following crude drugs in parts by weight: 12-20 parts of radix bupleuri, 9-15 parts of scutellaria baicalensis, 5-10 parts of ligusticum, 6-10 parts of cynanchum paniculatum, 10-15 parts of radix codonopsis, 6-9 parts of tuckahoe, 9-16 parts of medical stone, 7-10 parts of dragon bones, 8-9 parts of oysters, 9-15 parts of tribulus terrestris, 3-6 parts of magnets and 8-12 parts of wine-treated rhubarb. Crude drug materials selected by the liver calming and yang suppressing preparation are traditional Chinese medicine materials so as to have no toxic or side effects; and the liver calming and yang suppressing preparation has the effects of reconciling superficies and interior, constraining yin for suppressing hyperactive yang, calming the liver and relieving depression and the like and is remarkable in curative effect and capable of favorably relieving the pain of a patient.

Description

The suppressing the hyperactive liver and subsiding YANG agent of hypertensive patients feeling of fullness in the head disease and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the suppressing the hyperactive liver and subsiding YANG agent of a kind of hypertensive patients feeling of fullness in the head disease and preparation method.
Background technology
Hypertension is the chronic disease that a kind of arteriotony raises.The rising of blood pressure makes heart promotion blood increase in the burden of Ink vessel transfusing circulation time.Blood pressure has two kinds, systolic pressure and diastolic pressure, measured value when being respectively heartbeat when muscle contraction or diastole.Normal tranquillization blood pressure range is the most high scale of systolic pressure 100 – 140 millimetres of mercury mmHg() and the minimum reading of diastolic pressure 60 – 90 millimetres of mercury mmHg().Be then hypertension when blood pressure continues to be equal to or higher than 140/90 millimetres of mercury mmHg.Hypertension can cause the diseases such as apoplexy, heart disease, hemangioma, renal failure, hypertension be a kind of with arterial pressure rising for feature, can with the systemic disease of the functional or organic change of heart, blood vessel, brain and kidney and other organs, it have essential hypertension and secondary hypertension point.In most patient, hypertensive etiology unknown, is referred to as essential hypertension, and account for that total hypertension more than 95%.Secondary hypertension is then be secondary to other diseases.Modal is caused by kidney and adrenal gland diseases, and endocrine hypertension.In addition, by onset emergency and course advancement, can be divided into and delay into type and radical type, common to delay into type.Accelerated hypertension also claims malignant hypertension, accounts for 1% of hypertension, can change suddenly by delaying into type, also can onset.Malignant hypertension can occur in any age, but is the most common with 30-40 year.Blood pressure obviously raises, and diastolic pressure is many to be had weak at more than 17.3Kpa (130mmHg), the symptom such as thirsty, polyuria.Vision goes down rapidly, and there is retinal hemorrhage on optical fundus and oozes out, and often has bilateral papilloedema.There is albuminuria rapidly, hematuria and renal insufficiency.Also heart failure can occur, hypertensive encephalopathy and hypertensive crisis, course advancement rapidly more dies from uremia.Blood pressure rising is the fuse cord of various diseases, and the onset risk of the diseases such as coronary heart disease, heart failure and kidney disease can be made to increase.Because part hyperpietic there is no obvious clinical symptoms, hypertension is otherwise known as " the invisible killer " of human health.For hypertension, doctor trained in Western medicine adopts depressor treatment, as enalapril, nitrendipine, sodium nitroprusside, clonidine, chlortalidone etc., specifically will carry out medication according to the difference of individual and state of an illness rank, the traditional Chinese medical science has multiple therapy and the complementary therapies such as pillow therapy, massotherapy (head and foot) and tea therapy.
Publication number CN 103784575 A(application number 201310648980.1) Chinese patent literature disclose one and treat hypertensive Chinese medicine, comprising Flos Chrysanthemi Indici 5-10 part, XIARUCAO 5-10 part, Radix Glycyrrhizae 10-15 part, RADIX SALVIAE MILTIORRHIZAE 5-10 part, Herba Houttuyniae 5-10 part and Flos Lonicerae 2-10 part.Publication number CN 101890133 A(application number 201010223237.8) Chinese patent literature disclose a kind of medicine for lowering high blood pressure, raw material consists of Rhizoma Gastrodiae 8 ~ 12, Ramulus Uncariae Cum Uncis 10 ~ 14, Radix Scutellariae 8 ~ 12, Herba Apocyni veneti 18 ~ 22, the Radix Rehmanniae 8 ~ 12, the Radix Paeoniae Alba 8 ~ 12, Radix Salviae Miltiorrhizae 40 ~ 60, the Cortex Eucommiae 8 ~ 12, Herb Gynostemmae Pentaphylli 35 ~ 45, Folium Nelumbinis 35 ~ 45, Herba Leonuri 8 ~ 12, Radix Notoginseng 8 ~ 12, Fructus Crataegi 10 ~ 14, Semen Cassiae 8 ~ 12, Flos Chrysanthemi 8 ~ 12.Publication number CN 103690797 A(application number 201310721045.3) Chinese patent literature disclose a kind of medicine for lowering high blood pressure, be prepared from by Ramulus Uncariae Cum Uncis 20--30, Concha Haliotidis 20--30, Radix Paeoniae Alba 15--20, Radix Puerariae 15--30, Spica Prunellae 15--30, Radix Scutellariae 9--15, Flos Chrysanthemi 10--15, Rhizoma Chuanxiong 10--15, Herba Taxilli 10--15, Rhizoma Gastrodiae 10--15, Poria 5--10, Rhizoma Atractylodis Macrocephalae 5--10, Pheretima 10-20.
Hypertension is a kind of chronic disease, Long-term taking medicine is needed to treat the rising that could control blood pressure, and long-term taking depressor is except easily causing sclerosis of blood vessels and breaking, and cause cerebral vessels embolism, in etc. disease, and somewhat expensive, easily causes potential safety hazard and heavy financial burden to the treatment of patient, relative to the Therapeutic Method of Western medicine, treatment and the auxiliary treatment of Chinese medicine are more suitable for hyperpietic, have no side effect or side effect very little, be applicable to long-term taking.But the treatment of some Chinese medicine formula is also not obvious, therefore need the formula researching and developing better effects if further.
Summary of the invention
For the deficiencies in the prior art, the hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent the object of this invention is to provide a kind of taking convenience, be easy to carry, easily taking for a long time and preparation method.
Technical scheme of the present invention is:
The agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is prepared from primarily of following bulk drugs, is weight portion: Radix Bupleuri 12-20, Radix Scutellariae 9-15, Rhizoma Ligustici 5-10, Radix Cynanchi Paniculati 6-10, Radix Codonopsis 10-15, Poria 6-9, Maifanitum 9-16, Os Draconis 7-10, Concha Ostreae 8-9, Fructus Tribuli 9-15, Magnetitum 3-6, Radix et Rhizoma Rhei (stir-fried with wine) 8-12.
In preferred scheme, Radix Bupleuri 14-18, Radix Scutellariae 10-14, Rhizoma Ligustici 6-9, Radix Cynanchi Paniculati 7-9, Radix Codonopsis 11-14, Poria 7-8, Maifanitum 11-14, Os Draconis 8-9, Concha Ostreae 8.2-8.8, Fructus Tribuli 11-13, Magnetitum 4-5, Radix et Rhizoma Rhei (stir-fried with wine) 9-11.
Be more preferably, Radix Bupleuri 16, Radix Scutellariae 12, Rhizoma Ligustici 7.5, Radix Cynanchi Paniculati 8, Radix Codonopsis 12.5, Poria 7.5, Maifanitum 12.5, Os Draconis 8.5, Concha Ostreae 8.5, Fructus Tribuli 14, Magnetitum 4.5, Radix et Rhizoma Rhei (stir-fried with wine) 10.
The preparation method of described hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent decoction is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) be placed in non iron container by made for step (3) penetrating bag, add water and do not have sack 3cm, big fire boils 40 minutes, then adds other medical materials and step (1) (2) made medical material, adds water and do not have medical material 3cm, turns little fire and decocts, filter, collect filtrate after boiling;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, be evaporated to 1/3rd of original volume, obtain decoction.
The preparation method of described hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent decoction, step (4) turn after boiling a little fire decoct 30-40 minute (preferred, turn a little fire and decoct 33-37 minute; Be more preferably, turn little fire and decoct 35 minutes).
The preparation method of described pill is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, and remove the Concha Ostreae of impurity pulverization together with Os Draconis;
(4) get meal wheat stone decontamination, add the water of its quality 6 times, after boiling 25 minutes, filter, heating is concentrated, spraying dry;
(5) by other medical material decontaminations, clean, dry, made medical material pulverized 160 mesh sieves together with dry thing with step (1) (2) (3) (4), obtained medicated powder, added refined honey water, pill block, pill bar, gradation, round, and dry, whole ball, obtains pill.
The preparation method of described hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent pill, the concentration of step (5) refined honey water is that 20%-30%(is preferred, and the concentration of refined honey water is 23%-27%; Be more preferably, the concentration of refined honey water is 25%).
The preparation method of described capsule is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) made for step (3) penetrating bag is placed in non iron container, add water and do not have sack 3cm, big fire boils 40 minutes, then other medical materials and step (1) (2) made medical material is added, add water and do not have medical material 3cm, after boiling, a turn little fire is decocted and (preferably, is turned a little fire and decoct 33-37 minute for 30-40 minute; Be more preferably, turn little fire and decoct 35 minutes), filter, collect filtrate;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, concentrating under reduced pressure, spraying dry, pulverize and sieve, add pharmaceutical excipients, and mixing is granulated, dry, incapsulates, obtains capsule.
The preparation method of described hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent capsules agent, step (5) was pulverized 60-100 mesh sieve and (preferably, was pulverized 70-90 mesh sieve; Be more preferably, pulverized 80 mesh sieves).
The preparation method of described tablet is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, and remove the Concha Ostreae of impurity pulverization together with Os Draconis;
(4) get meal wheat stone decontamination, add the water of its quality 6 times, after boiling 25 minutes, filter, heating is concentrated, spraying dry;
(5) by other medical material decontaminations, clean, dry, made medical material pulverized 120 mesh sieves together with dry thing with step (1) (2) (3) (4), obtain medicated powder, add gelatinized corn starch and make soft material, granulate, dry, granulate, add the carboxymethyl starch sodium tabletting of tablet weight 2%, sterilizing, obtains tablet.
The preparation method of described hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent tablet, it is 60-80 DEG C (preferred, drying temperature used is 70 DEG C) that step (5) dries temperature used.
Hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent scientific formula provided by the invention, can be prepared into multiple dosage form, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected former spice is Chinese medicine material, without any side effects;
2, this prescription meets Chinese medicine principle and hyperpietic's body and mind feature completely, has reconciling superficies and interior, yin fluid astringing YANG hyperactivity suppressing, suppressing the hyperactive liver melancholy-relieving effect;
3, medicine source is easy to get, and medical material is with low cost, can alleviate patient economy burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Bupleuri: base is former: be the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor: bitter, are slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Radix Scutellariae: base is former: be the dry root of labiate Radix Scutellariae.Nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Rhizoma Ligustici: base is former: be dry rhizome and the root of Umbelliferae Ligustrum plant Rhizoma Ligustici or Rhizoma Ligustici.Nature and flavor: pungent, temperature.Gui Jing: function cures mainly: dispel the wind, cold expelling, dehumidifying, pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain.
Radix Cynanchi Paniculati: base is former: be the dry root and rhizome of asclepiadaceae Cynanchum plant Radix Cynanchi Paniculati.Nature and flavor: pungent, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: removing dampness of dispeling the wind, antalgesic-antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.
Radix Codonopsis: base is former: be Campanulaceae Radix Codonopsis, the plain dry root spending Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) or radix codonpsis tangshen.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Poria: base is former: be the dry sclerotia of On Polyporaceae Poria.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Maifanitum: base is former: be Acid-intermediate igneous rock rocks beschtauite.Composition: Maifanitum main component has silicon dioxide, aluminium oxide, ferrum oxide, ferrous oxide, magnesium oxide, calcium oxide, sodium oxide, potassium oxide, titanium dioxide, phosphorus pentoxide, manganese oxide, carbon dioxide, and the trace element such as fluorine, sulfur, strontium, barium, copper, zinc.The property of medicine: " detailed outline ": " sweet, temperature, nontoxic." function cures mainly: removing toxic substances and promoting granulation, damp eliminating spleen invigorating.Cure mainly carbuncle carbuncle on the back, acne, eczema, beriberi, miliaria, finger is chapped, chloasma, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.Generally make health product.Compatibility and incompatibility of drugs: superfine end need be ground during external application, otherwise easily cause pain.
Os Draconis (Os Draconis): base is former: for mammal in ancient times resembles the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex, bovine, deer class etc.Nature and flavor: puckery, sweet are flat.Gui Jing: GUIXIN, liver, kidney, large intestine channel.Function cures mainly: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Concha Ostreae (Concha Ostreae): base is former: be the shell of Ostreidae animal Crassostrea rivularis, long Concha Ostreae or Dalian Bay Concha Ostreae etc.Nature and flavor: salty wet, cool.Gui Jing: enter liver, kidney channel.Function cures mainly: yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, and arresting seminal emission reduces phlegm, softening the hard mass.Control infantile convulsion, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.
Fructus Tribuli (Fructus Atriplicis Sibiricae): base is former: be the fruit of zygophyllaceae plant Fructus Tribuli and Tribulus cistoides L.Nature and flavor: pungent, bitter are flat.Gui Jing: return liver, lung meridian.Function cures mainly: suppressing the hyperactive liver resolving depression, dispels the wind, improving eyesight.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.
Magnetitum: base is former: be the Ore of oxide-based mineral magnetic iron ore.Nature and flavor: salty, cold.Gui Jing: return liver, the heart, kidney channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.For having a dizzy spell, blurring of vision, Hiccough and deaf, palpitation with fear insomnia, asthma of suffering from a deficiency of the kidney.
Radix et Rhizoma Rhei (stir-fried with wine): Radix Et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Radix et Rhizoma Rhei (stir-fried with wine): get rhubarb tablets yellow wine and evenly spray, micro-stewing, put the micro-stir-fry of the interior slow fire of pot, taking-up is dried.Nature and flavor: bitter, cold.Gui Jing: return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.
embodiment 1the agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is prepared from primarily of following bulk drugs: Radix Bupleuri 12g, Radix Scutellariae 9g, Rhizoma Ligustici 5g, Radix Cynanchi Paniculati 6g, Radix Codonopsis 10g, Poria 6g, Maifanitum 9g, Os Draconis 7g, Concha Ostreae 8g, Fructus Tribuli 9g, Magnetitum 3g, Radix et Rhizoma Rhei (stir-fried with wine) 8g.
The preparation method of above-mentioned hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent decoction is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) be placed in non iron container by made for step (3) penetrating bag, add water and do not have sack 3cm, big fire boils 40 minutes, then add other medical materials and step (1) (2) made medical material, add water and do not have medical material 3cm, turn little fire after boiling and decoct 35 minutes, filter, collect filtrate;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, be evaporated to 1/3rd of original volume, obtain decoction.
embodiment 2the agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is prepared from primarily of following bulk drugs: Radix Bupleuri 20g, Radix Scutellariae 15g, Rhizoma Ligustici 10g, Radix Cynanchi Paniculati 10g, Radix Codonopsis 15g, Poria 9g, Maifanitum 16g, Os Draconis 10g, Concha Ostreae 9g, Fructus Tribuli 15g, Magnetitum 6g, Radix et Rhizoma Rhei (stir-fried with wine) 12g.
The preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent pill is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, and remove the Concha Ostreae of impurity pulverization together with Os Draconis;
(4) get meal wheat stone decontamination, add the water of its quality 6 times, after boiling 25 minutes, filter, heating is concentrated, spraying dry;
(5) by other medical material decontaminations, clean, dry, made medical material pulverized 160 mesh sieves together with dry thing with step (1) (2) (3) (4), obtained medicated powder, add refined honey water (concentration of refined honey water is 25%), pill block, pill bar, gradation, round, dry, whole ball, obtains pill.
Model case: xxx, female, 47 years old.Main suit: suffer from hypertension existing 2 years, took Captopril tablets and FUSAIMI PIAN, unstable condition before, blood pressure, often because raising when anything crops up, reaches as high as 181/104 millimetres of mercury, nearest three months, often feeling of fullness in the head, headache, dizzy, cardiopalmus and insomnia is felt, the dark red few tongue of tongue.
Take the present embodiment gained hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent pill after being introduced, each 4-6, every day 2 times, warm boiled water, 15 days courses for the treatment of.After taking a course for the treatment of, patient's feeling of fullness in the head, headache syndromes are obviously alleviated, blood pressure also declines to some extent, and after continuing to take two courses for the treatment of, patient is without malaise symptoms, blood pressure is down to 138/83 millimetres of mercury, and keeping stable, after consolidate curative effect takes a course for the treatment of, patient is almost recovered, follow up a case by regular visits in two years, patient is not recurred.
embodiment 3the agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is prepared from primarily of following bulk drugs: Radix Bupleuri 14g, Radix Scutellariae 10g, Rhizoma Ligustici 6g, Radix Cynanchi Paniculati 7g, Radix Codonopsis 11g, Poria 7g, Maifanitum 11g, Os Draconis 8g, Concha Ostreae 8.2g, Fructus Tribuli 11g, Magnetitum 4g, Radix et Rhizoma Rhei (stir-fried with wine) 9g.
The preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent capsules agent is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) be placed in non iron container by made for step (3) penetrating bag, add water and do not have sack 3cm, big fire boils 40 minutes, then add other medical materials and step (1) (2) made medical material, add water and do not have medical material 3cm, turn little fire after boiling and decoct 35 minutes, filter, collect filtrate;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, concentrating under reduced pressure, spraying dry, pulverized 80 mesh sieves, and added pharmaceutical excipients, and mixing is granulated, dry, incapsulates, obtains capsule.
Model case: xxx, female, 61 years old.Medical history: suffer from hypertension 5 years, attempted multiple Drug therapy, but effect is all not obvious, nearly three months, because disagreeing with daughter-in-law, emotion is irritated, occurs feeling of fullness in the head, recurrent dizziness, insomnia, build becomes fat, and red tongue, white and thin fur, blood pressure rises to 187/112 millimetres of mercury.
Introduce through good friend, learn the present invention, have the phychology of having a try in arms, taken the agent of the present embodiment gained hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent capsules, adopt twice daily, each 4-6, with warm boiled water, 15 days courses for the treatment of.After taking a course for the treatment of, symptom takes a turn for the better to some extent, and feeling of fullness in the head dizziness alleviates, and continues again to have taken one month, patient is not that symptom disappears substantially, and blood pressure maintains 155/91 millimetres of mercury, continues again to have taken one month, and patients' blood stablizes, condition is good, follows up a case by regular visits to, do not have recurrence after 1 year.
embodiment 4the agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is prepared from primarily of following bulk drugs: Radix Bupleuri 18g, Radix Scutellariae 14g, Rhizoma Ligustici 9g, Radix Cynanchi Paniculati 9g, Radix Codonopsis 14g, Poria 8g, Maifanitum 14g, Os Draconis 9g, Concha Ostreae 8.8g, Fructus Tribuli 13g, Magnetitum 5g, Radix et Rhizoma Rhei (stir-fried with wine) 11g.
The preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent tablet is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, and remove the Concha Ostreae of impurity pulverization together with Os Draconis;
(4) get meal wheat stone decontamination, add the water of its quality 6 times, after boiling 25 minutes, filter, heating is concentrated, spraying dry;
(5) by other medical material decontaminations, clean, dry, made medical material pulverized 120 mesh sieves together with dry thing with step (1) (2) (3) (4), obtain medicated powder, add gelatinized corn starch and make soft material, granulate, dry at 70 DEG C, granulate, add the carboxymethyl starch sodium tabletting of tablet weight 2%, sterilizing, obtains tablet.
Model case: xxx, man, 51 years old.Main suit: often treat with courtesy outside, likes eating meat and drinks, and recently over the past half year, often feels feeling of fullness in the head, headache, dim eyesight and dizzy, left side gums has a small amount of congestion point, dysphoria with feverish sensation in the chest palms and soles, rear medical check, record blood pressure 178/110 millimetres of mercury.
Take the present embodiment gained hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent tablet, adopt twice daily, each 4-5 sheet, with warm boiled water, 15 days courses for the treatment of.After taking a course for the treatment of, patient's feeling of fullness in the head obviously alleviates, headache relief, after continuing to take one month, malaise symptoms loses substantially, congestion point also disappears, and patient feels that body and mind is light, and blood pressure is 135/86 millimetres of mercury, for consolidate curative effect has been taken again one month, patients' blood keeps stable, and after drug withdrawal, the state of an illness does not recur.
embodiment 5the agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is prepared from primarily of following bulk drugs: Radix Bupleuri 16g, Radix Scutellariae 12g, Rhizoma Ligustici 7.5g, Radix Cynanchi Paniculati 8g, Radix Codonopsis 12.5g, Poria 7.5g, Maifanitum 12.5g, Os Draconis 8.5g, Concha Ostreae 8.5g, Fructus Tribuli 14g, Magnetitum 4.5g, Radix et Rhizoma Rhei (stir-fried with wine) 10g.
The preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent decoction is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) be placed in non iron container by made for step (3) penetrating bag, add water and do not have sack 3cm, big fire boils 40 minutes, then add other medical materials and step (1) (2) made medical material, add water and do not have medical material 3cm, turn little fire after boiling and decoct 35 minutes, filter, collect filtrate;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, be evaporated to 1/3rd of original volume, obtain decoction.
test example 1the clinical practice of embodiment 5 gained hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent decoction:
369 routine patients are screened, wherein women 185 example, male 184 example, oldest 63 years old, minimal ages 42 years old, 56.3 years old mean age, the course of disease 6 months-2 years, average course of disease 1 year 3 months in Vasculocardiology Deparment out-patient department of hospital.Experimenter all belongs to essential hypertension 1,2 grades and is primary symptom with feeling of fullness in the head; When not taking antihypertensive drugs, systolic pressure (SBP) >=140mmHg and/or diastolic pressure (DBP) >=90mmHg; Or have clear and definite hypertension history, take medicine and normotensive; Merge Treating Stable Angina Pectoris of Coronary Artery Disease, diabetes, cerebrovascular disease person, stable disease.Diagnostic criteria: formulate with reference to " new Chinese medicine guideline of clinical investigations " i.e. CM syndrome differentiation criterion.(1) cardinal symptom: feeling of fullness in the head, dizzy, headache (tenderness, localized pain), knee joint is soft, the soreness of waist, venation blood stasis (as purple dark in lip, gums, onyx, the red thread of skin, abdominal part blue veins exposes), ecchymosis; (2) minor symptom: cardiopalmus, insomnia, forgetful, tinnitus, dysphoria with feverish sensation in the chest palms and soles, squamous and dry skin, numb limbs and tense tendons; (3) the dark red few tongue of tongue or have ecchymosis, stringy and thready pulse and counting, or hesitant pulse, pulsus deletus.
Patient is divided into two groups at random, experimental group 215 example and matched group 154 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes embodiment 5 products obtained therefrom, take every day twice (warm), each 50m1-100m1(adjusts to some extent depending on concrete condition), 20 days courses for the treatment of, matched group takes other medicine (conventional medication such as Telmisartan Tablets, felodipine sustained-release tablets, FUFANG LUOBUMA PIAN).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom variation and untoward reaction situation.
Curative effect situation criterion: effective: clinical symptoms is eliminated substantially or cardinal symptom is eliminated, and diastolic pressure declines and reaches normal range; Effective: clinical symptoms obviously alleviates, diastolic pressure declines to some extent, but does not reach normal range; Invalid: clinical symptoms is improved not obvious or increased the weight of.
Result of the test: after the medication treatment of three courses for the treatment of, in experimental group, effective has 78 examples (36.3%), and disease effectively has 131 examples (60.9%), experimental group total effective rate 97.2%; The effective number of cases of matched group is 33 examples (21.4%), and effective number of cases is 81(52.6%), the total effective rate of matched group is 74.0%, and known embodiment 5 gained decoction has remarkable therapeutic effect relative to matched group institute with medicament to hypertensive patients feeling of fullness in the head disease.Take period, only have 2 examples to occur slight symptom of diarrhea in experimental group patient, and matched group has 5 examples to occur symptoms of emesis.
Take period two groups of patient's feeling of fullness in the head symptom variation as shown in table 1.
Table 1 patient feeling of fullness in the head symptom variation situation
The present invention have selected the Radix Bupleuri of reconciling superficies and interior, soothing the liver yang invigorating; The Radix Scutellariae of heat clearing and damp drying, eliminating fire and detoxication; The Rhizoma Ligustici of expelling wind and cold; Dispel the wind the Radix Cynanchi Paniculati of removing dampness, antalgesic-antipruritic; The Radix Codonopsis of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; The Poria of promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; The Os Draconis of tranquillizing and allaying excitement, hemostasis astringing intestine to stop diarrhea; The Concha Ostreae of yin fluid astringing YANG hyperactivity suppressing, resolving phlegm and softening hard masses; The Fructus Tribuli of suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight; The Magnetitum of tranquillizing and allaying excitement, suppressing the hyperactive liver and subsiding YANG; The Radix et Rhizoma Rhei (stir-fried with wine) of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, multi-medicament is collaborative plays drug effect, has good mitigation for malaise symptoms such as the feeling of fullness in the heads that hypertension causes, by improving symptom and regulating body function, thus controls the rising of blood pressure further.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. the agent of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG, is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Radix Bupleuri 12-20, Radix Scutellariae 9-15, Rhizoma Ligustici 5-10, Radix Cynanchi Paniculati 6-10, Radix Codonopsis 10-15, Poria 6-9, Maifanitum 9-16, Os Draconis 7-10, Concha Ostreae 8-9, Fructus Tribuli 9-15, Magnetitum 3-6, Radix et Rhizoma Rhei (stir-fried with wine) 8-12.
2. hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent as claimed in claim 1, is characterized in that, Radix Bupleuri 14-18, Radix Scutellariae 10-14, Rhizoma Ligustici 6-9, Radix Cynanchi Paniculati 7-9, Radix Codonopsis 11-14, Poria 7-8, Maifanitum 11-14, Os Draconis 8-9, Concha Ostreae 8.2-8.8, Fructus Tribuli 11-13, Magnetitum 4-5, Radix et Rhizoma Rhei (stir-fried with wine) 9-11 are (preferred, Radix Bupleuri 16, Radix Scutellariae 12, Rhizoma Ligustici 7.5, Radix Cynanchi Paniculati 8, Radix Codonopsis 12.5, Poria 7.5, Maifanitum 12.5, Os Draconis 8.5, Concha Ostreae 8.5, Fructus Tribuli 14, Magnetitum 4.5, Radix et Rhizoma Rhei (stir-fried with wine) 10).
3. the hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) be placed in non iron container by made for step (3) penetrating bag, add water and do not have sack 3cm, big fire boils 40 minutes, then adds other medical materials and step (1) (2) made medical material, adds water and do not have medical material 3cm, turns little fire and decocts, filter, collect filtrate after boiling;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, be evaporated to 1/3rd of original volume, obtain decoction.
4. the preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent decoction as claimed in claim 3, is characterized in that, step (4) turn after boiling a little fire decoct 30-40 minute (preferred, turn a little fire and decoct 33-37 minute; Be more preferably, turn little fire and decoct 35 minutes).
5. the hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry;
(4) get meal wheat stone decontamination, add the water of its quality 6 times, after boiling 25 minutes, filter, heating is concentrated, spraying dry;
(5) by other medical material decontaminations, clean, dry, made medical material pulverized 160 mesh sieves together with dry thing with step (1) (2) (3) (4), obtained medicated powder, added refined honey water, pill block, pill bar, gradation, round, and dry, whole ball, obtains pill.
6. the preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent pill as claimed in claim 5, is characterized in that, the concentration of step (5) refined honey water is that 20%-30%(is preferred, and the concentration of refined honey water is 23%-27%; Be more preferably, the concentration of refined honey water is 25%).
7. the hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, pulverization, with the Concha Ostreae of pulverizing and Os Draconis, load in penetrating bag together;
(4) made for step (3) penetrating bag is placed in non iron container, add water and do not have sack 3cm, big fire boils 40 minutes, then other medical materials and step (1) (2) made medical material is added, add water and do not have medical material 3cm, after boiling, a turn little fire is decocted and (preferably, is turned a little fire and decoct 33-37 minute for 30-40 minute; Be more preferably, turn little fire and decoct 35 minutes), filter, collect filtrate;
(5) medicinal residues add water, and again decoct 30 minutes, filter, merge twice filtrate, concentrating under reduced pressure, spraying dry, pulverize and sieve, add pharmaceutical excipients, and mixing is granulated, dry, incapsulates, obtains capsule.
8. the preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent capsules agent as claimed in claim 7, is characterized in that, step (5) was pulverized 60-100 mesh sieve and (preferably, pulverized 70-90 mesh sieve; Be more preferably, pulverized 80 mesh sieves).
9. the hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) remove Fructus Tribuli, mix thoroughly with yellow wine, vexed, be placed in pot, Steam by water bath 10 minutes, take out, dry;
(2) Radix Cynanchi Paniculati and Rhizoma Ligustici are cleaned, mix thoroughly with vinegar, run through, be cut into segment, be placed in the interior slow fire of pot and heat fried dry, take out, cool;
(3) get the Magnetitum of outwash, smash, put in crucible, forge in smokeless stove fire and be popular in, take out, pour in vinegar basin shortcake of quenching immediately into, smash to pieces, then forge and quench once, take out, dry, and remove the Concha Ostreae of impurity pulverization together with Os Draconis;
(4) get meal wheat stone decontamination, add the water of its quality 6 times, after boiling 25 minutes, filter, heating is concentrated, spraying dry;
(5) by other medical material decontaminations, clean, dry, made medical material pulverized 120 mesh sieves together with dry thing with step (1) (2) (3) (4), obtain medicated powder, add gelatinized corn starch and make soft material, granulate, dry, granulate, add the carboxymethyl starch sodium tabletting of tablet weight 2%, sterilizing, obtains tablet.
10. the preparation method of hypertensive patients feeling of fullness in the head disease suppressing the hyperactive liver and subsiding YANG agent tablet as claimed in claim 9, is characterized in that, it is 60-80 DEG C (preferred, drying temperature used is 70 DEG C) that step (5) dries temperature used.
CN201410813188.1A 2014-12-24 2014-12-24 Liver calming and yang suppressing preparation for treating hypertension complicated with fullness in head and preparation method of liver calming and yang suppressing preparation Pending CN104523860A (en)

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