CN104491787A - 一种用于表皮杀菌的中药液 - Google Patents
一种用于表皮杀菌的中药液 Download PDFInfo
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- CN104491787A CN104491787A CN201410746344.7A CN201410746344A CN104491787A CN 104491787 A CN104491787 A CN 104491787A CN 201410746344 A CN201410746344 A CN 201410746344A CN 104491787 A CN104491787 A CN 104491787A
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- parts
- folium
- radix
- skin
- leaves
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- Medicines Containing Plant Substances (AREA)
Abstract
一种用于表皮杀菌的中药液，由以下重量份数的组分组成：楝树果8-12份、绿茶8-12份、桑叶8-12份、大蒜叶8-12份、白鲜皮8-12份、艾叶8-12份、荆芥45-55份、地肤子45-55份、赤芍45-55份、白蒺藜45-55份、野葡萄根8-12份、八角8-12份、黄连8-12份、黄柏20-30份、厚朴25-35份、美人蕉花8-12份、芭蕉叶20-30份、荷叶8-12份、白芍花45-55份、丁香叶15-25份、椴木皮8-12份、干姜45-55份、花椒叶8-12份、辣椒叶45-55份、紫苏叶45-55份、牛膝25-35份、槐角20-30份、茼蒿8-12份及山豆根8-12份。本发明组分简单，配置成本低，消毒杀菌效果好，不刺激皮肤，不会使皮肤干涩，使用后会自动干燥，对人体健康无害。
Description
技术领域
本发明涉及杀菌剂技术领域，具体涉及一种用于表皮杀菌的中药液。
背景技术
现有的消毒剂很多，但通常并不能直接用于对人手的消毒和杀菌，而且由于它们一般都带有较强的刺激性，甚至是毒性，因此也难以在不用水漂洗的情况下，对人手进行快速的消毒和杀菌。而在许多情况下，又往往十分需要快速地用消毒剂直接对人手进行消毒，而不再利用水来作进一步的清洗。这一点是现有的消毒剂所难以实现的。
发明内容
本发明所要解决的技术问题在于提供一种使用安全可靠，成本低的用于表皮杀菌的中药液。
本发明所要解决的技术问题采用以下技术方案来实现：
一种用于表皮杀菌的中药液，由以下重量份数的组分组成：楝树果8-12份、绿茶8-12份、桑叶8-12份、大蒜叶8-12份、白鲜皮8-12份、艾叶8-12份、荆芥45-55份、地肤子45-55份、赤芍45-55份、白蒺藜45-55份、野葡萄根8-12份、八角8-12份、黄连8-12份、黄柏20-30份、厚朴25-35份、美人蕉花8-12份、芭蕉叶20-30份、荷叶8-12份、白芍花45-55份、丁香叶15-25份、椴木皮8-12份、干姜45-55份、花椒叶8-12份、辣椒叶45-55份、紫苏叶45-55份、牛膝25-35份、槐角20-30份、茼蒿8-12份及山豆根8-12份。
各组分的较佳重量份数为：楝树果10份、绿茶10份、桑叶10份、大蒜叶10份、白鲜皮10份、艾叶10份、荆芥50份、地肤子50份、赤芍50份、白蒺藜50份、野葡萄根10份、八角10份、黄连10份、黄柏25份、厚朴30份、美人蕉花10份、芭蕉叶25份、荷叶10份、白芍花50份、丁香叶20份、椴木皮10份、干姜50份、花椒叶10份、辣椒叶50份、紫苏叶50份、牛膝30份、槐角25份、 茼蒿10份及山豆根10份。
本发明的另一个目的是提供一种上述中药液的制备方法，步骤如下：
1)按上述重量份称取上述组分；
2)将上述药物粉碎，用70-75％乙醇提取二次，得到提取物浸膏，并干燥；
3)将上述干燥物送入研磨机研磨成细末，过400目筛，得到药末；
4)将上述药末加水稀释，制得药液，药末与水的比例为药末：水＝1.5:300。
本发明的有益效果是：本发明组分简单，配置成本低，消毒杀菌效果好，不刺激皮肤，不会使皮肤干涩，使用后会自动干燥，对人体健康无害，不须再用水冲洗，使用方便。特别适合于快速地对人手进行消毒处理，其功效比单纯以一般肥皂与水洗手更好。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例1
一种用于表皮杀菌的中药液，由以下重量份数的组分组成：楝树果10份、绿茶10份、桑叶10份、大蒜叶10份、白鲜皮10份、艾叶10份、荆芥50份、地肤子50份、赤芍50份、白蒺藜50份、野葡萄根10份、八角10份、黄连10份、黄柏25份、厚朴30份、美人蕉花10份、芭蕉叶25份、荷叶10份、白芍花50份、丁香叶20份、椴木皮10份、干姜50份、花椒叶10份、辣椒叶50份、紫苏叶50份、牛膝30份、槐角25份、茼蒿10份及山豆根10份。
制备步骤如下：
1)按上述重量份称取上述组分；
2)将上述药物粉碎，用70-75％乙醇提取二次，得到提取物浸膏，并干燥；
3)将上述干燥物送入研磨机研磨成细末，过400目筛，得到药末；
4)将上述药末加水稀释，制得药液，药末与水的比例为药末：水＝1.5:300。
实施例2
一种用于表皮杀菌的中药液，由以下重量份数的组分组成：楝树果12份、绿茶8份、桑叶12份、大蒜叶8份、白鲜皮12份、艾叶8份、荆芥55份、地肤子 45份、赤芍55份、白蒺藜45份、野葡萄根12份、八角8份、黄连12份、黄柏20份、厚朴35份、美人蕉花8份、芭蕉叶30份、荷叶8份、白芍花55份、丁香叶15份、椴木皮12份、干姜45份、花椒叶12份、辣椒叶45份、紫苏叶55份、牛膝25份、槐角30份、茼蒿8份及山豆根12份。
制备步骤如下：
1)按上述重量份称取上述组分；
2)将上述药物粉碎，用70-75％乙醇提取二次，得到提取物浸膏，并干燥；
3)将上述干燥物送入研磨机研磨成细末，过400目筛，得到药末；
4)将上述药末加水稀释，制得药液，药末与水的比例为药末：水＝1.5:300。
实施例3
一种用于表皮杀菌的中药液，由以下重量份数的组分组成：楝树果8份、绿茶12份、桑叶8份、大蒜叶12份、白鲜皮8份、艾叶12份、荆芥45份、地肤子55份、赤芍45份、白蒺藜55份、野葡萄根8份、八角12份、黄连8份、黄柏30份、厚朴25份、美人蕉花12份、芭蕉叶20份、荷叶12份、白芍花45份、丁香叶25份、椴木皮8份、干姜55份、花椒叶8份、辣椒叶55份、紫苏叶45份、牛膝35份、槐角20份、茼蒿12份及山豆根8份。
制备步骤如下：
1)按上述重量份称取上述组分；
2)将上述药物粉碎，用70-75％乙醇提取二次，得到提取物浸膏，并干燥；
3)将上述干燥物送入研磨机研磨成细末，过400目筛，得到药末；
4)将上述药末加水稀释，制得药液，药末与水的比例为药末：水＝1.5:300。
下面结合试验进一步说明本发明的效果：
1.实验目的
检验本发明中药消毒剂对金黄色葡萄球菌、大肠杆菌或、酵母菌、白色念珠菌的杀菌效果。
2.仪器与试药
2.1仪器
RE—52A型旋转蒸发仪，由上海亚荣仪器设备有限公司生产；HH-2K4型二列四孔智能水浴锅，由巩义市予华仪器有限责任公司生产；SW-CJ-F型单人双 面净化工作台，由苏州净化设备有限公司生产；8HP-080型细菌生化培养箱，由上海精宏实验设备有限公司生产；YXQ-LS-50S11型高压灭菌锅，由上海博迅实业有限公司医疗设备厂生产；FAl004型分析天平，由上海上天精密仪器有限公司生产；DC-T0实验型提取浓缩机，由上海达程实验设备有限公司生产。
2.2试药
中药消毒剂：实施例1-3；
2.3实验菌株
细菌：金黄色葡萄球菌(ATCC 6538)，大肠杆菌(8099或ATCC 25922)；酵母菌：白色念珠菌(ATCC 10231)，均由广东省微生物研究所提供。
3.实验方法
3.1杀菌性能测试方法
3.2.1染菌样片制备
取菌株第3代一14代的营养琼脂培养基斜面新鲜培养物(18h一24h)，用5mL、0.03mpl/L、pH值7.2-7.4磷酸盐缓冲液(PBS)洗下菌苔，后用上述PBS稀释至所需浓度，取100u1滴于样片(2.0cm×3.0cm)上，使回收菌数达1×104cfu/片-9×104cfu/片。
3.2.2菌液制备
取菌株第3代一14代的营养琼脂培养基斜面新鲜培养物(18h-24h)，用5ml、0.03mol/L，pH值7.2-7.4PBS洗下菌苔，使菌悬浮均匀后用上述PBS稀释至所需浓度。
3.2.3中和剂鉴定实验
试验用中药消毒剂，试验菌为金黄色葡萄球菌(ATCC6538)，中和剂为0.5％wt甘氨酸、0.5％wt吐温—80和0.1％wt卵磷脂的混合溶液，中和作用时间为1min，中药消毒剂和中和剂中和后得到中和产物溶液。试验时，用1％蛋白胨的磷酸盐缓冲液稀释试验菌成所需浓度菌悬液。取菌悬液滴染于脱脂白干纹布(1.0cm×l.0cm)上，制成菌片。先将中药消毒剂、中和剂、中和产物溶液和0.03mol/L、pH值7.2-7.4PBS，在19-21℃水浴中，保温5-10min。试验设8组分别为中药消毒剂+(菌片)、(中药消毒剂+菌片)+中和剂、中和剂+菌片、(中和产物溶液)+菌片、PBS+菌片(正常菌对照)、未加菌PBS对照、未加菌的中和 剂对照、未接种菌的培养基对照。试验结果，当第6、7、8组不长菌；第3、4、5组组间菌相差不超过10％；第1组不长菌或长菌量远低于第2组；第2组长菌量超过50cfu/片时，为所选中和剂及其浓度适宜。试验重复3次。
3.2.4杀菌试验
采用载体浸泡定量杀菌的试验方法。将试验菌24h斜面培养物用上述PBS洗下，制成菌悬液(要求的浓度为：用100u1滴于对照样片上，回收菌数为1×104cfu/片-9×104cfu/片)。取被试样片(2.0cm×3.0cm)和对照样片(与试样同质材料，同等大小，但不含抗菌材料，且经灭菌处理)各4片，分成4组置于4个灭菌平皿内。取上述菌悬液，分别在每个被试样片和对照样片上滴加100u1，均匀涂布，开始计时，作用20min，用无菌镊分别将样片投入含5ml相应中和剂的试管内，充分混匀，作适当稀释，然后取其中2个-3个稀释度，分别吸取0.5ml，置于两个平皿，用凉至40℃-45℃的营养琼脂培养基(细菌)或沙氏琼脂培养基(酵母菌)15ml作倾注，转动平皿，使其充分均匀，琼脂凝固后翻转平板，35℃±2℃培养48h(细菌)或72h(酵母菌)，作活菌菌落计数。试验重复3次，按下式计算杀菌率：
式中：X为杀菌率，％；NC为对照样品平均菌落数，cfu/片；NS为被试样品平均菌落数，cfu/片。
评价标准：杀菌率≥90％，产品有杀菌作用。
4.实验结果
4.1中和鉴定试验
试验结果表明，用含0.5％wt甘氨酸、0.5％wt吐温-80和0.1％wt卵磷脂的混合溶液+0.03mol/L、pH值7.2-7.4PBS溶液可中和残留消毒剂，且中和剂及中和产物溶液对所试微生物生长无影响，表明该中和剂适用于该复方中草药消毒剂杀菌试验。
表1中和剂鉴定试验
4.2中药消毒剂作用不同时间对细菌的杀灭效果
4.2.1对大肠埃希菌的杀菌效果
实验结果显示，中药消毒剂在常温条件下，试验重复3次，作用1min对大肠杆菌杀灭率为99.65％，作用5min后，杀灭率达99.9％以上。
表2对大肠埃希菌的杀菌效果
5.小结
本实验中药液，通过对大肠埃希菌、金黄色葡萄球菌、白色念珠菌等不同菌种的杀菌作用，评价小试及中试不同批次的中药消毒剂产品效果。实验结果表明，不同生产批次的中药消毒剂均具有杀菌作用，其中小试实验结果显示，0.25g/ml中药消毒剂对大肠埃希菌、金黄色葡萄球菌和白色念珠菌作用20min，杀灭率均达96％以上。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行 业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (3)
1.一种用于表皮杀菌的中药液，其特征在于，由以下重量份数的组分组成：楝树果8-12份、绿茶8-12份、桑叶8-12份、大蒜叶8-12份、白鲜皮8-12份、艾叶8-12份、荆芥45-55份、地肤子45-55份、赤芍45-55份、白蒺藜45-55份、野葡萄根8-12份、八角8-12份、黄连8-12份、黄柏20-30份、厚朴25-35份、美人蕉花8-12份、芭蕉叶20-30份、荷叶8-12份、白芍花45-55份、丁香叶15-25份、椴木皮8-12份、干姜45-55份、花椒叶8-12份、辣椒叶45-55份、紫苏叶45-55份、牛膝25-35份、槐角20-30份、茼蒿8-12份及山豆根8-12份。
2.根据权利要求1所述一种用于表皮杀菌的中药液，其特征在于，由以下重量份数的组分组成：楝树果10份、绿茶10份、桑叶10份、大蒜叶10份、白鲜皮10份、艾叶10份、荆芥50份、地肤子50份、赤芍50份、白蒺藜50份、野葡萄根10份、八角10份、黄连10份、黄柏25份、厚朴30份、美人蕉花10份、芭蕉叶25份、荷叶10份、白芍花50份、丁香叶20份、椴木皮10份、干姜50份、花椒叶10份、辣椒叶50份、紫苏叶50份、牛膝30份、槐角25份、茼蒿10份及山豆根10份。
3.一种权利要求1或2所述中药液的方法，其特征在于，包括如下步骤：
1)按上述重量份称取上述组分；
2)将上述药物粉碎，用70-75％乙醇提取二次，得到提取物浸膏，并干燥；
3)将上述干燥物送入研磨机研磨成细末，过400目筛，得到药末；
4)将上述药末加水稀释，制得药液，药末与水的比例为药末：水＝1.5:300。
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