CN104474268A - Externally applied ointment for treating diabetic ulcers and preparation method of externally applied ointment - Google Patents

Externally applied ointment for treating diabetic ulcers and preparation method of externally applied ointment Download PDF

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CN104474268A
CN104474268A CN 201410762118 CN201410762118A CN104474268A CN 104474268 A CN104474268 A CN 104474268A CN 201410762118 CN201410762118 CN 201410762118 CN 201410762118 A CN201410762118 A CN 201410762118A CN 104474268 A CN104474268 A CN 104474268A
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CN104474268B (en
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连士英
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连士英
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Abstract

The invention relates to an externally applied ointment for treating diabetic ulcers and a preparation method of the externally applied ointment. The ointment is prepared from the following active pharmaceutical ingredients according to weight ratio: 25g-35g of dark plum fruits, 25g-35g of calcined oyster shells, 15g-25g of safflower, 15g-25g of lightyellow sophora root, 15g-25g of pinellia tuber, 15g-25g of belvedere fruits, 15g-25g of densefruit pittany root-bark, 25g-35g of sinkiang arnebia root, 20g-30g of catechu, 5g-15g of natural indigo, 15g-25g of red dates, 10g-20g of pilose asiabell root, 10g-20g of fragrant solomonseal rhizome, 10g-20g of officinal magnolia bark, 25g-35g of common yam rhizome, 15g-25g of pearl powder, 10g-20g of erigeron breviscapus, 25g-35g of harlequin glorybower leaves, 25g-35g of pomegranate rind, 10g-20g of argy wormwood leaves, 10g-20g of Chinese honeylocust fruits, 10g-20g of Indian buead, 10g-20g of grosvenor momordica fruits, 15g-25g of common selfheal fruit-spike, 15g-25g of hematoxylon, 30g-50g of milkvetch root, 60-150g of beeswax, 100-200mg of vitamin C and 20-40mg of anisodamine. The traditional Chinese medicine preparation provided by the invention has the advantages of scientific formula compatibility, exact efficacy, high safety, controllable quality and low using amount of active pharmaceutical ingredients, and can greatly save production cost and enable industrial production and popularization in consumption crowds to be possible. The ointment can effectively treat the diabetic ulcers and realize few adverse reactions.

Description

一种治疗糖尿病溃疡的外用药膏及制备方法 An external preparation of creams and diabetic ulcers

技术领域 FIELD

[0001] 本发明涉及一种治疗糖尿病溃疡的中药制剂及其制备方法,特别是涉及一种治疗糖尿病溃疡的外用药膏及其制备方法。 [0001] The present invention relates to a method of preparing Chinese medicinal preparation for treating diabetes and ulcers, in particular, relates to topical creams and preparation method of treating a diabetic ulcer.

背景技术 Background technique

[0002] 溃疡是本领域的常见病之一,作为临床医师经常遇到溃疡的治疗。 [0002] ulcer is a common disease in the art, as clinicians often encountered in the treatment of ulcers. 溃疡的定义似乎不言而喻,然而,很多人对创面(wound)和溃疡(Ulcer-)的区别并不十分清楚。 Definition of ulcers seem self-evident, however, a lot of people on the wound (wound) and the difference between ulcer (Ulcer-) is not very clear. 一般认为"深达真皮或皮下组织缺损称为溃疡,其中圆孔形深在形的化脓性溃疡称为脓疮,位置很深的小孔性溃疡称为瘘孔。"Lever氏将溃疡定义为"治愈后遗留疤痕的表皮和真皮的部分缺损。"另一方面,Anderson病理学认为"组织或器官的表面附近发生炎症,强列的炎症刺激引起组织坏死,脱落后成为溃疡。"以上可见皮肤学在组织形态,将上皮和真皮的部分缺损称为溃疡,不一定有炎症症状作为条件。 Generally considered "deep dermis or subcutaneous tissue ulcer defect referred to, wherein the circular-shaped deep abscesses referred shaped in purulent ulcers, deep ulcers hole position referred to the fistula." Lever's ulcer is defined as the "partial defects after healing of the scar dermis and epidermis." On the other hand, Anderson pathology that "near the surface of inflamed tissues or organs, inflammation strongly induced tissue necrosis, ulceration after becoming detached." more visible skin Studies in morphology, partial defect called epithelium and dermal ulcers, inflammatory symptoms are not necessarily as a condition. 病理学上脏器表面先有炎症,坏死组织脱落后形成溃疡。 Pathologically surface prior organ inflammation, ulcers formed necrotic tissue. 即皮肤学中将创面(wound)划为溃疡的范畴,而病理学中则不将其划为溃疡的范畴。 I.e., in the dermatological wounds (Wound) ulcers classified as visible, but not to classify the pathology is visible ulcers.

[0003] 皮肤溃疡是皮肤破损累及真皮或更深层组织所形成的局限性缺损,愈合后遗留瘢痕。 [0003] Skin ulcers are limitations involving the skin damaged dermis or deeper tissue defects formed, scar healing. 至于糖尿病溃疡,本发明人认为它并非是上述意义的疮疡、创面溃疡或者溃疡,它是一种因为患糖尿病而引起的下肢和体表组织发生溃疡体征的特殊溃疡,主要发病在下肢,与因创伤等原因引起的创疡或者发病有着根本的区别,是目前世界上还没有理想治疗药物的疾病。 As diabetic ulcers, the present invention is that it is not the above sense sores, ulcers or ulcer wound, which is one kind of special ulcer caused by diabetes because the lower limbs and body tissue ulceration signs, mainly in the lower extremities incidence, and due to causes such as trauma or wounds and ulcers pathogenesis is fundamentally different, there is no ideal treatment of diseases in the world of drugs.

[0004] 中国专利ZL 93 1 00276 1披露了一种治疗热损伤的药物组合物,该药物组合物由以下组分组成,按照药物组合物总重量计,(A)3-5%的蜂蜡,(B)85-97%的含有黄芩、黄连、黄柏、蚯蚓和罂粟壳的芝麻油的提取物,其中黄芩、黄连、黄柏、蚯蚓和罂粟壳按照其干药重量计分别占芝麻油总重量的2-10%。 [0004] Chinese Patent ZL 93 1 00276 1 discloses a method of treating thermal injuries pharmaceutical composition, the pharmaceutical composition comprises the following constituents according to the total weight of the pharmaceutical composition, (A) 3-5% beeswax, (B) 85-97% containing baicalin, Huanglian, Huangbai, earthworm and poppy capsule extract of sesame oil, wherein the baicalin, Huanglian, Huangbai, earthworm and poppy capsule is in the dry weight of the drug, respectively, of the total weight of sesame oil 2- 10%.

[0005] 糖尿病溃疡的发病机理非常复杂,目前还没有统一的明确认识,总结起来包括三个相互作用的过程:血管病变、神经病变和免疫病变。 [0005] The pathogenesis of diabetic ulcers are very complicated, there is no clear unified understanding, summed up includes three interacting processes: vascular disease, neuropathy, and immune disorders. (1)血管病变:血管病变分为两大类, 一大类是大血管内膜的病变、一大类是微血管病变,由于血管病变导致下肢和体表软组织缺血导致溃疡。 (1) vascular disease: vascular disease are divided into two categories, one category is large intimal lesions, one major microvascular disease, due to vascular lesions caused by lower limb ischemia and superficial soft tissue ulceration. (2)神经病变:神经病变参与了糖尿病足部病变的早期发病机制,也是糖尿病足部溃疡最重要的危险因素。 (2) Neuropathy: Neuropathy involved in the pathogenesis of early diabetic foot lesions, diabetic foot ulcers is the most important risk factor. 在此过程中,所有的神经功能都受到了损害,但通常是最长、最细的神经纤维首先受损,包括支配足部肌肉的运动神经。 In this process, all are subject to neurological damage, but usually the longest, finest nerve fibers are first damaged, including the innervation of the foot muscles. 蚓状肌功能的丧失导致足部畸形,使跖趾关节下、足趾背部或趾尖等部位压力或摩擦增加,容易发生溃疡。 Loss of function results lumbrical foot deformity, so that the metatarsophalangeal joint, and so increase the toe or toe portion of the back pressure or friction, prone to ulceration. 植物神经功能受损也在神经病变的早期出现,导致动静脉血管短路,组织灌注率降低。 Impaired autonomic neuropathy are early, leading to arteriovenous short circuit, reduce the rate of tissue perfusion. 出现脱发、皮脂腺和汗腺功能丧失,导致皮肤干燥、鳞屑和容易皲裂。 Hair loss, loss of function of sebaceous and sweat glands, causing dry skin, scaly and cracked easily. (3)免疫病变:免疫病变在糖尿病患者感染的发生中所起作用仍存在争议。 (3) immune disorders: immune disorders play a role in the occurrence of infection in patients with diabetes remains controversial. 大多数研究者相信血糖控制不满意使患者易于感染。 Most researchers believe glycemic control are not satisfied so that patients prone to infection. 但是糖尿病患者的体液免疫似乎是正常的,循环中免疫球蛋白水平正常或偏高,B淋巴细胞数目正常。 However, diabetic patients humoral immunity seem to be normal, normal levels of circulating immunoglobulins or high, the number of normal B lymphocytes. 在小鼠模型中,未发现抗体反应或补体结合的缺陷。 In the mouse model, the defect antibody reaction or complement binding was observed.

[0006] 糖尿病足的主要症状表现为糖尿病人因下肢的血管病变、神经病变及感染等因素导致下肢的疼痛、麻木、足部的溃疡及肢端坏疽,临床上统称为糖尿病足(俗称烂脚)其表现为: 1.患者皮肤瘙痒,干而无汗,肢端凉、浮肿或干枯,皮肤颜色暗及色素斑,毳毛脱落。 [0006] The main symptoms of diabetic foot for people with diabetes because of the performance factors of vascular disease, neuropathy and infection of the lower extremities resulting in lower extremity pain, numbness, foot ulcers and gangrene, collectively known as diabetic foot clinic (commonly known as bad feet ) which is as follows: 1. patient itchy skin, dry without sweating, cold extremities, swelling or dry, dark skin color and pigmentation, vellus hair loss.

[0007] 2.肢端刺痛、灼痛、麻木、感觉迟钝或丧失,脚踩棉絮感。 [0007] 2. extremities tingling, burning, numbness, or loss of sensation, foot cotton feel. 鸭步行走,间歇性跛行, 休息痛。 Duck walk away, intermittent claudication, rest pain.

[0008] 3.肢端营养不良,肌肉萎缩张力差,关节韧带易损伤。 [0008] 3. extremities malnutrition, muscle atrophy tension difference, easy to damage the ligaments.

[0009] 4.常见跖骨头下陷,跖趾关节弯曲形成弓形足、槌状趾.鸡爪趾、夏科关节。 [0009] 4. The common metatarsal head undercut arcuate metatarsophalangeal joint bent foot, hammer toe. Chicken toe, Charcot joint. 骨质破坏可发生病理性骨折等。 Destruction of bone pathologic fractures may occur.

[0010] 5.足背动脉搏动减弱或消失。 [0010] The dorsal artery pulse weakened or disappeared. 深浅反射迟钝或消失。 Depth reflex slow or disappear.

[0011] 6.肢端皮肤干裂或水疱、血疱、糜烂、溃疡、坏疽或坏死。 [0011] 6. The acral blisters or dry skin, blood blister, erosion, ulcer, gangrene or necrosis.

[0012] 通常,糖尿病患者可伴有多种皮肤损害,长期代谢紊乱,微血管和周围神经发生病变,是导致皮肤溃疡的基础。 [0012] In general, patients with diabetes may be associated with a variety of skin damage, long-term metabolic disorder, capillaries and peripheral nerve lesions, it is the basis for cause skin ulcers. 因为长期血管病变使血管尤其是下肢血管硬化、狭窄,影响血供,导致皮肤营养障碍;微血管病变可使神经内膜血供下降,自主神经病变加重,神经病变还可使皮肤痛觉、压觉阈值上升,足底压力承受部位改变;因此,以足部尤其是趾感染居多, 在这种情况下,患者皮肤如出现损伤,则修复能力差,容易继发感染、溃疡、坏疽。 Because long-term vascular lesions of the lower extremities, especially the blood vessels hardening of the arteries, narrowing, affecting the blood supply, resulting in skin dystrophy; microvascular disease can Endoneurium blood supply decreased, autonomic neuropathy aggravated, neuropathy can also cause skin pain, pressure sensation threshold rise, the pressure foot receiving portion changes; thus, in particular the toe to foot infections mostly, in this case, the patient's skin such damage occurs, the repair ability, easy to secondary infections, ulcers, gangrene. 大部分患者发病时有明显诱因,以外伤多见,足癣、甲癣和长期使用抗生素的糖尿病患者足部还容易发生真菌感染;老年糖尿病患者由于病程长,活动少,末梢循环差,更容易发生皮肤溃疡,老年患者因血糖升高使机体免疫力下降,溃疡形成后感染的概率很高,严重者导致蜂窝组织炎、骨髓炎和败血症等使截肢率大大增加。 Most patients have a significant incentive to onset, common to trauma, patients foot tinea pedis, onychomycosis, and long-term use of antibiotics is also prone to diabetes, fungal infections; elderly patients due to fewer longer duration of activity, poor peripheral circulation, easier skin ulcers, elevated blood sugar in elderly patients due to the decreased immunity, high probability of infection after ulcer formation, leading to severe cellulitis, osteomyelitis and septicemia the amputation rate is greatly increased. 通常糖尿病皮肤溃疡应采取内科综合治疗,包括控制血糖,抗感染,改善微循环及创面局部处理。 Diabetic skin ulcers usually should take comprehensive medical treatment, including blood glucose control, anti-infection, improve microcirculation and local wound treatment. 例如:使用头孢类抗生素、林可霉素、青霉素、克拉霉素、阿昔洛韦、阿莫西林双氯西林钠胶襄、复方磺胺甲恶唑等进行抗感染治疗;夕卜用"百多邦"等等。 For example: the use of anti-infective therapy cephalosporins, lincomycin, penicillin, clarithromycin, acyclovir, dicloxacillin sodium Jiaoxiang amoxicillin, sulfamethoxazole and the like; Bu Xi with "more than one hundred state "and so on. 但是糖尿病溃疡,一旦发生,临床上难以有理想治愈创面的有效方法,目前仍然时有采取截肢的外科方法。 However, diabetic ulcers, in the event it is difficult to have an effective way to heal the wounds of the ideal clinical, there are surgical methods while still taking amputation. 临床上十分需要一种非手术疗法治疗糖尿病溃疡的方法,也非常需要新的医疗技术或者药物。 It is clinically indicated a non-surgical method of therapy for diabetic ulcers, but also a great need for new medical technologies or drugs.

[0013] 因此,仍然需要进一步研究治疗糖尿病溃疡的药物组合物,以获得更好的治疗效果。 [0013] Thus, there remains a need for further study of the treatment of diabetic ulcer pharmaceutical composition, to achieve better therapeutic effect.

发明内容 SUMMARY

[0014] 本发明的目的是提供一种治疗糖尿病溃疡的外用药膏及制备方法,该治疗糖尿病溃疡的外用药膏安全、稳定,能有效地治疗糖尿病溃疡,并且不良反应少。 [0014] The object of the present invention is to provide a method of preparing topical creams and diabetic ulcers, the treatment of diabetic ulcers topical creams safe, stable, effective in treating diabetic ulcers, and adverse reactions.

[0015] 本发明的目的是通过以下的技术方案来实现的: 一种治疗糖尿病溃疡的外用药膏,其特征是,按以下原料药的组成按重量比制成膏剂: 乌梅25g-35g、煅牡蛎25g-35g、红花15g-25g、苦参15g-25g、半夏15g-25g、地肤子15g-25g、白藓皮15g-25g、紫草25g-35g、儿茶20g-30g、青黛5g-15g、红麥15g-25g、党参10g-20g、玉竹10g-20g、厚朴10g-20g、山药25g-35g、珍珠粉15g-25g、灯盏花10g-20g、 臭梧桐叶25g-35g、石槽皮25g-35g、艾叶10g-20g、阜角10g-20g、获茶10g-20g、罗汉果10g-20g、夏枯草15g-25g、苏术15g-25g、黄苗30g-50 g、蜂錯60-150 g、维生素C 100_200mg、山直菪喊20_40mg。 [0015] The object of the present invention is achieved by the following technical solution: a method of treating diabetic ulcers topical creams, wherein the weight ratio of the prepared paste according to the composition of drug: ebony 25g-35g, calcined oyster 25g-35g, safflower 15g-25g, Sophora 15g-25g, Pinellia 15g-25g, Kochia scoparia 15g-25g, dictamni 15g-25g, Radix 25g-35g, catechu 20g-30g, indigo 5g -15g, red wheat 15g-25g, Codonopsis 10g-20g, Polygonatum 10g-20g, Magnolia 10g-20g, Chinese yam 25g-35g, pearl powder 15g-25g, Dengzhanhua 10g-20g, smelly Indus leaves 25g-35g, shicao skin 25g-35g, leaves 10g-20g, Fu angle 10g-20g, is eligible for tea 10g-20g, Mangosteen 10g-20g, Prunella 15g-25g, Su surgery 15g-25g, seedlings yellow 30g-50 g, bee wrong 60-150 g, vitamin C 100_200mg, mountain straight henbane call 20_40mg.

[0016] 如所述的一种治疗糖尿病溃疡的外用药膏,其特征是,原料药的组成按重量比为: 乌梅25g、煅牡蛎35g、红花15g、苦参25g、半夏15g、地肤子15g、白藓皮25g、紫草25g、 儿茶20g、青黛15g、红枣15g、党参20g、玉竹20g、厚朴10g、山药35g、珍珠粉25g、灯盏花2〇g、臭梧桐叶35g、石槽皮25g、艾叶20g、阜角10g、获考:20g、罗汉果15g、夏枯草25g、苏术18g、黄苗30g、蜂錯80g、维生素C 120mg、山莨菪碱20mg。 [0016] The topical ointment for treating diabetes ulcers as described, characterized in that the composition of the feed by weight ratio of drug: ebony 25g, calcined oyster 35g, safflower 15g, Sophora 25g, Pinellia 15g, kochia sub-15g, white moss skin 25g, Radix 25g, catechu 20g, indigo 15g, jujube 15g, Codonopsis 20g, Polygonatum 20g, Magnolia 10g, Chinese yam 35g, pearl powder 25g, Dengzhanhua 2〇g, smelly Indus leaves 35g , the stone of the skin 25g, leaves 20g, Fu corner 10g, eligible test: 20g, Mangosteen 15g, Prunella 25g, Su surgery 18g, yellow seedlings 30g, bee wrong 80g, vitamin C 120mg, anisodamine 20mg.

[0017] 如所述的一种治疗糖尿病溃疡的外用药膏,其特征是,原料药的组成按重量比为: 乌梅30g、煅牡蛎30g、红花20g、苦参20g、半夏20g、地肤子20g、白藓皮20g、紫草30g、 儿茶25克、青黛10克、红枣20g、党参15g、玉竹12g、厚朴15g、山药30g、珍珠粉20g、灯盏花15g、臭梧桐叶30g、石槽皮30g、艾叶15g、阜角15g、获考:15g、罗汉果15g、夏枯草20g、苏术20g、黄苗40g、蜂錯100克、维生素C 150mg、山莨菪碱20mg。 [0017] The topical ointment for treating diabetes ulcers as described, characterized in that the composition of the feed by weight ratio of drug: ebony 30g, calcined oyster 30g, safflower 20g, Sophora flavescens 20g, Pinellia 20g, kochia sub-20g, white moss skin 20g, Radix 30g, catechu 25 grams, 10 grams of indigo, red dates 20g, Codonopsis 15g, Polygonatum 12g, Magnolia 15g, Chinese yam 30g, pearl powder 20g, Dengzhanhua 15g, smelly Indus leaves 30g , the stone of the skin 30g, leaves 15g, Fu corner 15g, eligible test: 15g, Mangosteen 15g, Prunella 20g, Su surgery 20g, yellow seedlings 40g, bee wrong 100g vitamin C 150mg, anisodamine 20mg.

[0018] 如所述的一种治疗糖尿病溃疡的外用药膏的制备方法,其特征是,包含如下步骤: (1) 称取乌梅、煅牡蛎、红花、苦参、半夏、地肤子、白藓皮、紫草、儿茶、青黛、红枣、党参、 玉竹、厚朴、山药、珍珠粉、灯盏花、臭梧桐叶、石榴皮、艾叶、皂角、茯苓、罗汉果、夏枯草、苏术、黄芪,粉碎,过筛,置于水中浸泡2-4日; (2) 用旺火熬至沸腾后改为文火,熬至煎煮液体积为150-350mL,冷却,除去药渣; (3) 向煎煮液中加入蜂蜡,搅拌均匀至膏状,高压蒸气灭菌,冷却; (4) 加入研磨成粉末状的维生素C和山莨菪碱,搅拌均匀,即得。 [0018] The method for preparing the topical creams of treating a diabetic ulcer, characterized in that, comprising the steps of: (1) Weigh ebony, calcined oyster, safflower, Sophora, Pinellia, Kochia scoparia, white moss skin, Radix, catechu, indigo, red dates, Codonopsis, odoratum, Magnolia, yams, pearl powder, Dengzhanhua, smelly Indus leaves, peel, leaves, herb, Poria, Mangosteen, Prunella, Su surgery, tragacanth, pulverized, sieved, is placed in water soaked 2-4; (2) after boiling to stir boil to a slow boil decoction volume of 150-350mL, cooling, removing the dregs; ( 3) was added to the decoction beeswax, stir until a paste, autoclaving, cooling; (4) milled into a powder form was added vitamin C and anisodamine uniformly stirred, to obtain.

[0019] 本发明治疗糖尿病溃疡的外用药膏具有以下优点: 1、 本发明的中药制剂组方配伍科学,疗效确切,安全性高,质量可控; 2、 本发明的原料药用量低,大大节省了生产成本,为工业化生产和消费人群的普及提供了可能; 3、 本发明的软膏剂可有效治疗糖尿病溃疡,并且不良反应少。 [0019] Treatment of diabetic ulcers topical creams of the present invention has the following advantages: 1. Chinese medicine prescription scientific compatibility of the present invention, effective, controllable safe, quality; 2, a pharmaceutically acceptable amount of low raw material of the present invention greatly saving production costs, it provides the possibility of universal industrial production and consumer groups; 3, ointments of the present invention may be effective in treating diabetic ulcers, and adverse reactions.

具体实施方式 Detailed ways

[0020] 本发明一种治疗糖尿病溃疡的外用药膏,按以下原料药的组成按重量比制成膏剂: 乌梅25g-35g、煅牡蛎25g-35g、红花15g-25g、苦参15g-25g、半夏15g-25g、地肤子15g-25g、白藓皮15g-25g、紫草25g-35g、儿茶20g-30g、青黛5g-15g、红麥15g-25g、党参10g-20g、玉竹10g-20g、厚朴10g-20g、山药25g-35g、珍珠粉15g-25g、灯盏花10g-20g、 臭梧桐叶25g-35g、石槽皮25g-35g、艾叶10g-20g、阜角10g-20g、获茶10g-20g、罗汉果10g-20g、夏枯草15g-25g、苏术15g-25g、黄苗30g-50 g、蜂錯60-150 g、维生素C 100_200mg、山直菪喊20_40mg。 [0020] The present invention is a method of treating diabetic ulcers topical creams, according to the following composition by weight ratio of drug paste made: ebony 25g-35g, calcined oyster 25g-35g, safflower 15g-25g, Sophora 15g-25g, Pinellia 15g-25g, Kochia scoparia 15g-25g, dictamni 15g-25g, Radix 25g-35g, catechu 20g-30g, indigo 5g-15g, red wheat 15g-25g, Codonopsis 10g-20g, Polygonatum 10g-20g, Magnolia 10g-20g, Chinese yam 25g-35g, pearl powder 15g-25g, Dengzhanhua 10g-20g, smelly Indus leaves 25g-35g, the stone of skin 25g-35g, leaves 10g-20g, Fu angle 10g- 20g, won tea 10g-20g, Mangosteen 10g-20g, Prunella 15g-25g, Su surgery 15g-25g, Huang Miao 30g-50 g, bee wrong 60-150 g, vitamin C 100_200mg, mountain straight henbane call 20_40mg.

[0021]本发明治疗糖尿病溃疡的外用药膏的制备方法,包含下列步骤: (1)称取乌梅、煅牡蛎、红花、苦参、半夏、地肤子、白藓皮、紫草、儿茶、青黛、红枣、党参、 玉竹、厚朴、山药、珍珠粉、灯盏花、臭梧桐叶、石榴皮、艾叶、皂角、茯苓、罗汉果、夏枯草、苏术、黄芪,粉碎,过筛,置于水中浸泡2-4日; (2) 用旺火熬至沸腾后改为文火,熬至煎煮液体积为150-350mL,冷却,除去药渣; (3) 向煎煮液中加入蜂蜡,搅拌均匀至膏状,高压蒸气灭菌,冷却; (4) 加入研磨成粉末状的维生素C和山莨菪碱,搅拌均匀,即得。 [0021] A method for the treatment of diabetic ulcers topical creams of the present invention, comprising the following steps: (1) Weigh ebony, calcined oyster, safflower, Sophora, Pinellia, Kochia scoparia, dictamni, comfrey, children tea, indigo, red dates, Codonopsis, odoratum, Magnolia, yams, pearl powder, Dengzhanhua, smelly Indus leaves, peel, leaves, herb, Poria, Mangosteen, Prunella, Su surgery, astragalus, crushing, screening , placed in water for 2-4 days; (2) boiling stir boil to a slow boil decoction volume of 150-350mL, cooling, removing the dregs; (3) was added to the decoction beeswax, stir until a paste, autoclaving, cooling; (4) milled into a powder form was added vitamin C and anisodamine, stir to obtain.

[0022] 在上述的原料药还可以通过本领域的常规方法制成软膏剂。 [0022] In the ointment drug may also be made by conventional methods in the art.

[0023] 本发明治疗糖尿病溃疡的外用药膏的原料药中: 乌梅:味酸、性涩,平。 [0023] The drug of the present invention the treatment of diabetic ulcers in topical creams: ebony: Pickle, astringent, flat. 归肝、脾、肺、大肠经。 The liver, spleen, lung, large intestine. 主治涩肠,生津。 Indications intestinal astringent, Sheng Jin. 用于久泻;痢疾;便血; 尿血的功能。 For Diarrhea; diarrhea; stool; hematuria function. 乌梅里的苹果酸把适量的水分导引到大肠,形成粪便而排出体外;煅牡蛎:收敛固涩,制酸止痛,重镇安神,软坚散结;红花:有活血化瘀,散湿去肿的功效;苦参:主治清热燥湿,利尿。 Jaume appropriate amount of malic acid in the water guided into the large intestine, formed feces excreted; calcined oyster: convergence Guse, acid pain, nerves city, Endometriosis; safflower: blood circulation there, wet bulk to the swelling effectiveness; Sophora: Indications heat and dampness, diuretic. 用于热痢,便血;半夏:有燥湿化痰,降逆止呕,生用消疖肿作用;地肤子:有清热利湿,祛风止痒功效;白藓皮:有清热燥湿,祛风解毒之功效;紫草:能凉血,活血,清热,解毒。 For heat diarrhea, blood in the stool; Pinellia: YES phlegm dampness Jiangni vomiting, swelling effect with raw consumption boils; Fructus: YES heat and dampness, chills and itching effect; dictamni: with heat and dry efficacy of wet, chills detoxification; Lithospermum: cooling blood, blood, detoxification. 治淋浊,热结便秘;儿茶:《纲目》:〃治斑疹、痘毒,活血凉血,利大肠。 Governance pouring muddy, hot junction constipation; catechu: "outline": 〃 rule rash, pox poison, blood cooling, Lee colon. 〃《吉林中草药》:〃治便秘,尿血〃;青黛:有清热、生津、化痰、止血、敛疮、生肌、定痛等功能;红枣:味甘性温、归脾胃经,有补中益气、养血安神、缓和药性的功能;党参:性平,味甘,具有补中益气、健脾益肺之功效,还可以增强人体免疫力,提高超氧化物歧化酶的活性,具有调节胃肠运动、抗溃疡、抑制胃酸分泌、降低胃蛋白酶活性的作用。 〃 "Jilin Chinese herbal medicine": 〃 constipation, blood in the urine 〃; Qingdai: there is heat, fluid, phlegm, bleeding, sores, tissue regeneration, and pain and other functions; jujube: Sweet and warm, spleen and stomach, with deficiency of , nourishing the nerves, ease of medicinal function; dangshen: nature, sweet, with a deficiency of spleen Yifei effect, can enhance the immune system, increase the activity of superoxide dismutase, with adjustable gastric gut motility, anti-ulcer, inhibition of gastric acid secretion, reducing the activity of pepsin. 现代研究,党参有增强免疫力、扩张血管、降压、改善微循环、增强造血功能等作用;玉竹:主治养阴,润燥,除烦,止渴;厚朴: 味辛、性温,具有行气化湿、温中止痛的功效。 Modern research, there Codonopsis enhance immunity, dilation of blood vessels, blood pressure, improve microcirculation, enhance hematopoietic function and so on; odoratum: Indications Yin, moistening, Chufan, thirst; Magnolia: spicy, warm, having rows gasification of wet, warm the analgesic effect. 对葡萄球菌、链球菌、赤痢杆菌、巴氏杆菌、霍乱弧菌有较强的抗菌作用,对食积气滞、腹胀便秘等疾病有治疗作用;山药:有滋养强壮, 助消化,敛虚汗,止泻之功效,主治脾虚腹泻、消化不良的慢性肠炎;珍珠粉:有安神定惊、 解毒生肌等功效,现代研究还表明珍珠粉在提高人体免疫力、补充钙质等方面都具有独特的作用;灯盏花:性寒、微苦、甘温辛,具有微寒解毒、祛风除湿、活血化瘀、通经活络、消炎止痛的功效。 There staphylococcus, streptococcus, dysentery bacillus, Pasteurella, Vibrio cholerae strong antibacterial effect, stagnation of food product gas, bloating and constipation treatment of diseases; yam: nourish strong, digestion, convergence sweating, stop the effectiveness of diarrhea, attending spleen diarrhea, dyspepsia, chronic colitis; pearl powder: a tranquilizer the frightened, detoxification myogenic and other effects, modern research also showed that pearl powder to improve human immunity, supplement calcium and other aspects have a unique role ; erigeron: cold, bitter, sweet warm octene, having a slightly cold detoxification Qufengchushi, blood circulation, through the meridians, anti-inflammatory analgesic effect. 可扩张微血管改善血管痉挛和微循环,同时可抑制红细胞,血小板聚集,降解纤维蛋白原,有效降低血粘度,减弱凝血,溶解微血栓,具有明显抗凝;臭梧桐叶:可祛风除湿、平肝降压、解毒杀虫。 Can improve expansion of capillaries and microcirculation vasospasm, while suppressing RBC, platelet aggregation, fibrinogen degradation, reduce blood viscosity, reduced blood clotting, dissolved microthrombi obvious anticoagulant; smell parasol trees: Qufengchushi be flat liver blood pressure, insecticide detoxification. 功能主治痢疾、痈疽疮毒;石榴皮:入大肠、肺,肾经。 Indications dysentery, ulcer sore; pomegranate rind: the colon, lung, kidney. 主治涩肠, 止血,驱虫。 Indications astringent intestinal bleeding, de-worming. 治久泻,久痢,便血,脱肛等;艾叶:味辛、苦,性温,有小毒,具有温经止血,散寒止痛,降湿杀虫的功效;皂角:辛、咸,温。 Cure Chronic Diarrhea, Jiu Li, blood in the stool, rectal prolapse and so on; leaves: spicy, bitter, warm, a small drug, with the temperature by bleeding, cold pain, lower humidity insecticidal efficacy; saponins: spicy, salty, warm. 毒可消积化食开胃,并含有瓜尔豆胶;皂荚刺(皂针)内含黄酮甙、酚类,氨基酸;茯苓:味甘、淡、性平,入药具有利水渗湿、益脾和胃、宁心安神之功用。 Toxicity may be appetizing food consumer product, and contains guar gum; acacia puncture (needle soap) containing glycosides, phenols, acids; Poria: sweet, light, flat, medicine having diuresis Shenshi, spleen and stomach, Anshen the function. 现代医学研究:茯苓能增强机体免疫功能;罗汉果:味甘性凉,归肺、大肠经、有润肺止咳、生津止渴的功效、有润肠通便的功效;夏枯草:性辛、苦,寒。 Modern medical research: Poria can enhance immune function; Mangosteen: sweet and cool, the lung, large intestine, lungs and cough, thirst effect, have laxative effect; Prunella: sexual acrid, bitter cold . 归肝、胆经。 The liver and gall bladder. 功效: 清热泻火,明目,散结消肿;苏木:味甘、咸,性辛凉。 Efficacy: heat purging fire, eyesight, Sanjie swelling; hematoxylin: sweet, salty, Xin Liang. 归心;肝;胃;脾经。 The heart; liver; stomach; spleen. 能活血祛瘀,消肿定痛;黄芪:有增强机体免疫功能和较广泛的抗菌作用;蜂蜡:是工蜂腹部下面四对腊腺分泌的物质。 Can stasis, swelling and pain; Astragalus: YES enhance immune function and broader antibacterial activity; Beeswax: abdominal following four pairs of worker bees wax glands secrete a substance. 其主要成分有:酸类、游离脂肪酸、游离脂肪醇和碳水化合物。 The main ingredients are: acids, free fatty acids, free fatty alcohols and carbohydrates. 此外,还有类胡萝卜素、维生素A、芳香物质等。 In addition, carotenoids, vitamin A, aromatic substances and the like. 收涩,敛疮,生肌,止痛。 Astringent, sore, myogenic pain. 外用于溃疡不敛,臁疮糜烂,创伤,烧、 烫伤;维生素C :维生素C为抗体及胶原形成,组织修补(包括某些氧化还原作用),苯丙氨酸、酪氨酸、叶酸的代谢,铁、碳水化合物的利用,脂肪、蛋白质的合成,维持免疫功能,羟化与羟色胺,保持血管的完整;山莨菪碱:抗胆碱能神经药,具有松弛平滑肌,解除血管痉挛, 改善微循环的作用,并有镇痛作用。 Not for grabbing the outer ulcer, ecthyma erosion, trauma, burn, burn; Vitamin C: Vitamin C and collagen is formed as an antibody, tissue repair (including some redox), the metabolism of phenylalanine, tyrosine, folate , iron, use of carbohydrate, fat, protein synthesis, maintenance of immune function, hydroxylation and serotonin, maintaining vessel integrity; anisodamine: anti-cholinergic drugs having smooth muscle relaxation, relieve spasm, microcirculation the role and analgesic effect.

[0024] 糖尿病溃疡的发病涉及到下肢血管、神经和感染等多种因素,糖尿病患者常合并血管病变,尤其是肢端微血管病变,致局部组织灌注不足,引起组织缺血坏死;血糖长期增高,机体代谢紊乱,使神经组织营养障碍,故出现神经病变;加之糖尿病患者本身身体虚弱,抵抗力低下,因而易出现感染。 [0024] The pathogenesis of diabetic ulcers involves a variety of factors lower limb blood vessels, nerves and infection, often associated with vascular disease in patients with diabetes, especially microvascular disease extremities, causing local tissue hypoperfusion, causing tissue necrosis; long-term blood glucose increased, the body's metabolism, nutritional disorders nerve tissue, it appears neuropathy; in addition to diabetes itself is weak, low resistance, and thus prone to infection. 糖尿病溃疡部位细菌培养结果表明,I度溃疡物多为G+ 球菌感染,II度、III度溃疡主要是G-杆菌。 Diabetic ulcer bacterial culture results indicate, the degree of ulcers was mostly the I G + bacterial infections, of II degree ulcers mostly III G- bacilli. 所以治疗要点:一是改善局部血液循环和营养,二是抗感染。 So treatment points: First, to improve local blood circulation and nutrition, and second, anti-infective. 经临床验证,本发明药膏治疗糖尿病下肢溃疡效果显著,主要基于该药具有以下机制: 抗感染能力强。 Clinically proven ointment diabetic leg ulcers remarkable effect of the present invention, the drug has mainly based on the following mechanisms: strong resistance to infection. 药膏中的黄芪、厚朴具有较强的抗感染能力,且能阻菌、抑菌、排菌、促进细菌变异、破坏细菌的生存条件、使细菌失去侵蚀活组织的能力及降低毒性。 Ointments astragalus, Magnolia has a strong resistance to infection, and can bacteria resistance, antibacterial, row of bacteria, promote bacterial mutation, destroy the living conditions of the bacteria, the bacteria lose their ability to attack living tissue and reduce toxicity. 有研究证明,其抗感染原理可能与以下几点有关:其可使创面保持生理性湿润环境,从而维持组织细胞的正常生命条件,增加了其自身的抗感染能力;药膏的流动性不利于细菌在组织中寄宿、 生长、繁殖;能使细菌变异,降低致病菌的毒性和侵蚀力。 Studies have shown that its anti-infection a few principles may be related to the following: it can keep the wound moist physiological environment, in order to maintain normal life conditions of tissue cells, increasing their own resistance to infection; liquidity is not conducive to bacterial ointment in host tissue, the growth and reproduction; mutant bacteria can reduce the toxicity of pathogenic bacteria and erosion forces. 根据的抗感染能力强这一特性,周身配合使用敏感抗生素可有效控制感染。 Strong resistance to infection based on this characteristic, the whole body with the use of sensitive antibiotics can effectively control the infection.

[0025] 糖尿病下肢溃疡坏疽者机体代谢紊乱、血糖升高、组织修复能力下降,故创面甚难愈合。 [0025] lower extremity diabetic ulcers gangrene metabolism disorders, elevated blood sugar, decrease tissue repair, it is exceedingly difficult to wound healing. 同时,创面感染及坏死组织也使机体血糖进一步升高。 At the same time, wound infection and necrotic tissue also further increase the body's blood sugar. 在控制饮食、口服降糖药、应用胰岛素的同时,应用清除坏死组织、对抗感染、阻止血糖的进一步升高。 While controlling diet, oral hypoglycemic agents, insulin, and application removal of necrotic tissue and fight the infection, prevent a further increase in blood sugar. 本发明的原料药中,红花、党参、紫草、蜂蜡、山莨菪碱等药物能改善局部微循环,增加局部血流量,创造有利于组织生长的环境促进创面愈合,可起到协同及累加作用,促进溃疡坏疽愈合。 The drug of the present invention, safflower, Codonopsis, comfrey, beeswax, anisodamine other drugs can improve microcirculation, increase local blood flow, creating an environment conducive to the growth promoting tissue wound healing, can play a synergistic and additive role in promoting the healing of ulcers gangrene. 研究表明, 本发明的外用药膏可有效阻止创面水分蒸发的能力接近于正常皮肤,并可在减少水分蒸发的同时为创面提供近似生理性的湿润环境。 Studies have shown that topical creams of the present invention can effectively prevent the evaporation capacity of the wound is close to normal skin, while reducing the water evaporation and provided approximate physiological moist environment for the wound.

[0026] 实施例1 处方:乌梅25g、煅牡蛎35g、红花15g、苦参25g、半夏15g、地肤子15g、白藓皮25g、紫草25g、儿茶20g、青黛15g、红麥15g、党参20g、玉竹20g、厚朴10g、山药35g、珍珠粉25g、灯盖花20g、臭梧桐叶35g、石槽皮25g、艾叶20g、阜角10g、获考:20g、罗汉果15g、夏枯草25g、 苏术18g、黄苗30g、蜂錯80g、维生素C 120mg、山莨菪碱20mg。 [0026] Formulation Example 1: ebony 25g, calcined oyster 35g, safflower 15g, Sophora 25g, Pinellia 15g, Kochia scoparia 15g, dictamni 25g, Lithospermum 25g, catechu 20g, indigo 15g, red wheat 15g, Codonopsis 20g, Polygonatum 20g, Magnolia 10g, Chinese yam 35g, pearl powder 25g, lamp cover flower 20g, smelly Indus leaves 35g, the stone of skin 25g, leaves 20g, Fu angle 10g, won the test: 20g, Mangosteen 15g, Prunella 25g, Su surgery 18g, Huang Miao 30g, bee wrong 80g, vitamin C 120mg, anisodamine 20mg.

[0027] 制备方法:⑴称取乌梅、煅牡蛎、红花、苦参、半夏、地肤子、白藓皮、紫草、儿茶、 青黛、红枣、党参、玉竹、厚朴、山药、珍珠粉、灯盏花、臭梧桐叶、石榴皮、艾叶、皂角、茯苓、罗汉果、夏枯草、苏术、黄芪,粉碎,过筛,置于水中浸泡2日;丨2)用旺火熬至沸腾后改为文火, 熬至煎煮液体积为150mL,冷却,除去药渣;⑶向煎煮液中加入蜂蜡,搅拌均匀,至膏状,高压蒸气灭菌,冷却;W加入研磨成粉末状的维生素C和山莨菪碱,搅拌均匀,即得。 [0027] Preparation: ⑴ weighed ebony, calcined oyster, safflower, Sophora, Pinellia, Kochia scoparia, dictamni, comfrey, catechu, indigo, jujube, Codonopsis, Polygonatum, Magnolia, yams , pearl powder, Dengzhanhua, smelly Indus leaves, peel, leaves, herb, Poria, Mangosteen, Prunella, Su surgery, astragalus, crushing, screening, placed on the 2nd soaked in water; Shu 2) boil stir to boiling to a slow boil decoction volume of 150 mL, cooled, remove the dregs; ⑶ beeswax was added to the boiling mixture, and uniformly stirred to a paste, autoclaving, cooled; W is ground to a powder was added shaped anisodamine vitamin C and stirred evenly to obtain.

[0028] 实施例2 处方:乌梅30g、煅牡蛎30g、红花20g、苦参20g、半夏20g、地肤子20g、白藓皮20g、紫草30g、儿茶25克、青黛10克、红枣20g、党参15g、玉竹12g、厚朴15g、山药30g、珍珠粉20g、灯盖花15g、臭梧桐叶30g、石槽皮30g、艾叶15g、阜角15g、获考:15g、罗汉果15g、夏枯草20g、苏术20g、黄苗40g、蜂錯100克、维生素C 150mg、山莨菪碱30mg。 [0028] Example 2 Prescription: ebony 30g, calcined oyster 30g, safflower 20g, Sophora flavescens 20g, Pinellia 20g, Kochia scoparia 20g, dictamni 20g, Lithospermum 30g, catechu 25 grams, 10 grams of indigo, jujube 20g, Codonopsis 15g, Polygonatum 12g, Magnolia 15g, Chinese yam 30g, pearl powder 20g, lamp cover flower 15g, smelly Indus leaves 30g, the stone of skin 30g, leaves 15g, Fu angle 15g, won the test: 15g, 15g Mangosteen , Prunella 20g, Su surgery 20g, yellow seedlings 40g, bee wrong 100g vitamin C 150mg, anisodamine 30mg.

[0029] 制备方法:[H称取乌梅、煅牡蛎、红花、苦参、半夏、地肤子、白藓皮、紫草、儿茶、青黛、红枣、党参、玉竹、厚朴、山药、珍珠粉、灯盏花、臭梧桐叶、石榴皮、艾叶、皂角、茯苓、罗汉果、夏枯草、苏术、黄芪,粉碎,过筛,置于水中浸泡3日;[2)用旺火熬至沸腾后改为文火,熬至煎煮液体积为200mL,冷却,除去药渣;[3)向煎煮液中加入蜂蜡,搅拌均匀,至膏状,高压蒸气灭菌,冷却;[4]加入研磨成粉末状的维生素C和山莨菪碱,搅拌均匀,即得。 [0029] Preparation: [H ebony weighed, calcined oyster, safflower, Sophora, Pinellia, Kochia scoparia, dictamni, comfrey, catechu, indigo, jujube, Codonopsis, Polygonatum, Magnolia, yam, pearl powder, erigeron, smelly Indus leaves, peel, leaves, saponins, Poria, Mangosteen, Prunella, Su surgery, tragacanth, pulverized, sieved, is placed in water for 3 days; [2) stir after boiling boil to a slow boil boiling liquid volume of 200 mL, cooled, remove the dregs; [3) beeswax was added to the boiling mixture, uniformly stirring, to a paste, autoclaving, cooling; [4 ] was added to the milled powdery anisodamine vitamin C and stirred uniformly, ie.

[0030] 试验例(1)试验对象: 2010年6月-2014年5月,我院共收住院糖尿病下肢溃疡患者共128例,其中男性93 例、女性35例;年龄49岁-82岁,平均年龄57. 2岁;糖尿病病程3个月-18年,平均病程7. 4年;糖尿病下肢溃疡病程26天-2. 8年,平均病程6. 7个月。 [0030] Test Example (1) Subjects: June 2010 --2014 May, the hospital received a total of hospitalized patients with diabetic foot ulcers were 128 cases, including 35 males and 93 cases female; aged 49 -82 years old, average age 57.2 years; duration of diabetes 3 month - 18 years, average duration of 7.4 years; diabetic foot ulcers 26 days duration -28 years, average duration of 6.7 months. 合并瘫患者23例,病史等一般资料见表1。 General information combined in 23 patients with paralysis, history, etc. shown in Table 1.

[0031] 表1试验对象的各项糖尿病指标情况 [0031] Table 1 Index of diabetic subjects case

Figure CN104474268AD00081

溃疡分度:根据Armstrong糖尿病溃疡诊断标准,将溃疡分为3度。 Ulcer indexing: The diagnostic criteria Armstrong diabetic ulcer, ulcer will be divided into three degrees. I度:溃疡仅限于皮肤层;II度:溃疡透过皮肤,深入肌肉层;III度:溃疡波及骨和关节。 I degree: ulcers limited to the skin layers; degree II: through the skin ulcers, deep muscle layer; degree III: ulcers spread to bones and joints. 本组患者经积极治疗原发病、使用敏感抗生素、传统清创及局部换药治疗后,无明显好转。 This group of patients after active treatment of the primary disease, the use of sensitive antibiotics, debridement and local traditional dressing treatment, no significant improvement.

[0032] 全部患者共有263处溃疡,面积最小者约I. 0厘米X 1. 5厘米,面积最大者约为9.0厘米X 11.0厘米。 [0032] All patients with ulcers total of 263, the smallest area of ​​about I. 0 cm X 1. 5 cm by about 9.0 cm largest X 11.0 cm. 其中,溃疡部位及所占比例见表2。 Wherein the ulcer and the proportion shown in Table 2.

[0033] 表2试验对象的糖尿病溃疡情况 Diabetic ulcers where [0033] Table 2 Test object

Figure CN104474268AD00082

对其中98例溃疡面进行细菌培养,结果为阳性的76例,分离出79株细菌,培养菌株见表3。 Wherein 98 cases of ulcers bacterial culture results were positive in 76, 79 isolated from bacteria, culturing the strain in Table 3.

[0034] 表3试验对象溃疡面细菌培养情况 [0034] Table 3 Test subject bacterial culture case of ulcers

Figure CN104474268AD00083

(2)治疗方法: 用碘伏液为患者彻底清洗溃疡面及周围皮肤,清除变性坏死组织、结痂及分泌物,然后用0. 9%氯化钠溶液冲洗创面,再用无菌纱布拭干后涂抹本发明实施例1制备的软膏剂,视创面大小和部位不同采用暴露、半暴露或包扎疗法。 (2) Treatment method: iodophor solution is thoroughly washed with patients ulcers and surrounding skin, tissue necrosis clear, crusted secretions and then wash the wound with 0.9% sodium chloride solution, then sterile gauze swab the present invention is applied dry ointment prepared in Example 1, depending on size and location of the wound using different exposure, half exposure or bandaged. 每日换药1次〜2次,每次换药时清除液化坏死组织及杂物。 1 ~ 2 times daily dressing, clearing liquefaction of necrotic tissue and debris at each dressing change.

[0035] (3)观察指标创面收缩率[=创面长(臟)*创面宽(mm) /原长(mm) *原宽(mm) ] *100%、创面愈合时间(d)、创基色泽、创面渗液或分泌物、过敏及不良反应。 [0035] (3) the rate of wound contraction OUTCOME MEASURES [wound length = (dirty) * Year wide (mm) / original length (mm) * original width (mm)] * 100%, the healing time (d), creating color group, secretions or wound exudate, allergy and adverse reactions.

[0036] 参照国家有关标准设计: _痊愈:创面完全愈合,创面上皮化,创面收缩率为100% ; -显效:创面缩小75%_100%,创面收缩率75%_100% ; -有效:创面缩小50%-75%,创面收缩率50%-75% ; -微效:创面缩小25%-50%,创面收缩率25%-50% ; -无效:创面缩小不足25%,创面收缩率>25%。 [0036] Referring to design national standards: _ cure: complete healing of the wound, the wound epithelialization, wound contraction rate was 100%; - effective: 75% _100% wound reduction, wound contraction of 75% _100%; - Effective: Wound reduction 50% to 75%, wound contraction of 50% -75%; - minor: 25% -50% reduction of wound, wound contraction of 25% -50%; - invalid: less than 25% reduction of wound, wound shrinkage> 25 %.

[0037] 溃疡面渗液评估: _很少量:溃疡面湿润,但无法测出渗液量,或没有渗液; -少量:溃疡面渗液少,沾湿敷料25%以下; -中量:渗出液沾湿敷料25%-75% ; -大量:渗出液沾湿敷料75%-100%。 [0037] Evaluation ulcer exudate: _ a small amount: moist ulcers, but can not measure the amount of exudate, or no exudate; - a small amount: less exudate ulcers, wet dressing 25% or less; - the amount of : exudate 25% -75% wet dressing; - Bulk: wet dressing exudate 75-100%.

[0038]观察六周,每周记录一次。 [0038] observed six weeks recorded once a week.

[0039] (4)试验结果: 通过观察创面收缩率、创基色泽、创面渗液或分泌物、过敏及不良反应等指标,具体试验结果见表4-6。 [0039] (4) Test results: The rate of wound contraction, creating color-yl, secretions or wound exudate, and adverse allergic reactions and other indicators, specific test results in Table 4-6.

Figure CN104474268AD00091

Figure CN104474268AD00101

试验结果表明,创面I期愈合103例,治愈率为83. 59%,其疗程最短的14天、最长的42天。 The results showed that wound healing I 103 cases, the cure rate was 83.59%, which is the shortest course of 14 days, the longest 42 days. 其中,有12例经14天-21天换药后,创面无坏死组织及分泌物,肉芽较新鲜(占);8 例因肌腱及骨外露面积较大行皮瓣转移修复创面(占9. 37%) ;5例行截趾手术(占8. 6%)。 Wherein 12 cases over 14 to 21 days after the dressing, the wound no necrotic tissue and secretions, granulation fresher (accounting); but 8 of larger tendon and bone exposed wound repair line flap (9 accounted for. 37%); 5 Apodizers routine surgery (accounting for 8.6%). 128例患者均无皮肤红肿、瘙痒等过敏反应。 128 patients had no skin irritation, itching and other allergic reactions. 上述试验数据表明,本发明的软膏剂可有效治疗糖尿病溃疡,并且不良反应少。 Above test data show that the ointment of the present invention may be effective in treating diabetic ulcers, and adverse reactions.

Claims (4)

1. 一种治疗糖尿病溃疡的外用药膏,其特征是,按以下原料药的组成按重量比制成膏剂: 乌梅25g-35g、煅牡蛎25g-35g、红花15g-25g、苦参15g-25g、半夏15g-25g、地肤子15g-25g、白藓皮15g-25g、紫草25g-35g、儿茶20g-30g、青黛5g-15g、红麥15g-25g、党参10g-20g、玉竹10g-20g、厚朴10g-20g、山药25g-35g、珍珠粉15g-25g、灯盏花10g-20g、 臭梧桐叶25g-35g、石槽皮25g-35g、艾叶10g-20g、阜角10g-20g、获茶10g-20g、罗汉果10g-20g、夏枯草15g-25g、苏术15g-25g、黄苗30g-50 g、蜂錯60-150 g、维生素C 100_200mg、山直菪喊20_40mg。 A topical ointment treating diabetic ulcers, wherein the weight ratio of the prepared paste according to the composition of drug: ebony 25g-35g, calcined oyster 25g-35g, safflower 15g-25g, 15g-25g matrine , Pinellia 15g-25g, Kochia scoparia 15g-25g, dictamni 15g-25g, Radix 25g-35g, catechu 20g-30g, indigo 5g-15g, red wheat 15g-25g, Codonopsis 10g-20g, jade bamboo 10g-20g, Magnolia 10g-20g, Chinese yam 25g-35g, pearl powder 15g-25g, Dengzhanhua 10g-20g, smelly Indus leaves 25g-35g, the stone of skin 25g-35g, leaves 10g-20g, 10g Fu angle -20g, won tea 10g-20g, Mangosteen 10g-20g, Prunella 15g-25g, Su surgery 15g-25g, Huang Miao 30g-50 g, bee wrong 60-150 g, vitamin C 100_200mg, mountain straight henbane call 20_40mg.
2. 如权利要求1所述的一种治疗糖尿病溃疡的外用药膏,其特征是,原料药的组成按重量比为: 乌梅25g、煅牡蛎35g、红花15g、苦参25g、半夏15g、地肤子15g、白藓皮25g、紫草25g、 儿茶20g、青黛15g、红枣15g、党参20g、玉竹20g、厚朴10g、山药35g、珍珠粉25g、灯盏花2〇g、臭梧桐叶35g、石槽皮25g、艾叶20g、阜角10g、获考:20g、罗汉果15g、夏枯草25g、苏术18g、黄苗30g、蜂錯80g、维生素C 120mg、山莨菪碱20mg。 2. A method of treating diabetic ulcers topical ointment according to claim 1, characterized in that the composition of the feed by weight ratio of drug: ebony 25g, calcined oyster 35g, safflower 15g, Sophora 25g, Pinellia 15g, Kochia scoparia 15g, white moss skin 25g, Radix 25g, catechu 20g, indigo 15g, jujube 15g, Codonopsis 20g, Polygonatum 20g, Magnolia 10g, Chinese yam 35g, pearl powder 25g, Dengzhanhua 2〇g, smelly Indus leaves 35g, the stone of skin 25g, leaves 20g, Fu angle 10g, won the test: 20g, Mangosteen 15g, Prunella 25g, Su surgery 18g, Huang Miao 30g, bee wrong 80g, vitamin C 120mg, anisodamine 20mg.
3. 如权利要求1所述的一种治疗糖尿病溃疡的外用药膏,其特征是,原料药的组成按重量比为: 乌梅30g、煅牡蛎30g、红花20g、苦参20g、半夏20g、地肤子20g、白藓皮20g、紫草30g、 儿茶25克、青黛10克、红枣20g、党参15g、玉竹12g、厚朴15g、山药30g、珍珠粉20g、灯盏花15g、臭梧桐叶30g、石槽皮30g、艾叶15g、阜角15g、获考:15g、罗汉果15g、夏枯草20g、苏术20g、黄苗40g、蜂錯100克、维生素C 150mg、山莨菪碱20mg。 3. A method of treating diabetic ulcers topical ointment according to claim 1, characterized in that the composition of the feed by weight ratio of drug: ebony 30g, calcined oyster 30g, safflower 20g, Sophora flavescens 20g, Pinellia 20g, Kochia scoparia 20g, dictamni 20g, Lithospermum 30g, catechu 25 grams, 10 grams of indigo, jujube 20g, Codonopsis 15g, Polygonatum 12g, Magnolia 15g, Chinese yam 30g, pearl powder 20g, erigeron 15g, smelly Indus leaves 30g, the stone of skin 30g, leaves 15g, Fu angle 15g, won the test: 15g, Mangosteen 15g, Prunella 20g, Su surgery 20g, Huang Miao 40g, bee wrong 100 grams of vitamin C 150mg, anisodamine 20mg.
4. 如权利要求1、2或3所述的一种治疗糖尿病溃疡的外用药膏的制备方法,其特征是, 包含如下步骤: (1) 称取乌梅、煅牡蛎、红花、苦参、半夏、地肤子、白藓皮、紫草、儿茶、青黛、红枣、党参、 玉竹、厚朴、山药、珍珠粉、灯盏花、臭梧桐叶、石榴皮、艾叶、皂角、茯苓、罗汉果、夏枯草、苏术、黄芪,粉碎,过筛,置于水中浸泡2-4日; (2) 用旺火熬至沸腾后改为文火,熬至煎煮液体积为150-350mL,冷却,除去药渣; (3) 向煎煮液中加入蜂蜡,搅拌均匀至膏状,高压蒸气灭菌,冷却; (4) 加入研磨成粉末状的维生素C和山莨菪碱,搅拌均匀,即得。 4. The preparation method of treating a diabetic ulcer, or topical ointment according to claim 2 or 3, characterized in that, comprising the steps of: (1) Weigh ebony, calcined oyster, safflower, Sophora, half summer, belvedere fruit, white moss skin, Radix, catechu, indigo, red dates, Codonopsis, odoratum, Magnolia, yams, pearl powder, Dengzhanhua, smelly Indus leaves, peel, leaves, herb, Poria, Mangosteen, Prunella, Su surgery, tragacanth, pulverized, sieved, soaked in water placed 2-4; (2) after boiling to stir boil to a slow boil decoction volume of 150-350mL, cooled to remove the dregs; (3) was added to the decoction beeswax, stir until a paste, autoclaving, cooling; (4) milled into a powder form was added vitamin C and anisodamine uniformly stirred, to obtain .
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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN102233085A (en) * 2010-10-01 2011-11-09 刘叙光 External application drug for treating skin diseases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102233085A (en) * 2010-10-01 2011-11-09 刘叙光 External application drug for treating skin diseases

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* Cited by examiner, † Cited by third party
Title
袁琳等: "胰岛素联合用药治疗糖尿病足的研究进展", 《护理研究》 *
马静: "中医药治疗糖尿病足临床研究近况", 《河北中医》 *

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