CN104474174A - 一种治疗鼻炎的药物及其制备方法 - Google Patents

一种治疗鼻炎的药物及其制备方法 Download PDF

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CN104474174A
CN104474174A CN201410691409.2A CN201410691409A CN104474174A CN 104474174 A CN104474174 A CN 104474174A CN 201410691409 A CN201410691409 A CN 201410691409A CN 104474174 A CN104474174 A CN 104474174A
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李坤
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李坤
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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Abstract

本发明公开了一种治疗鼻炎的药物及其制备方法,其主要是由黄芪、白术、防风、鱼腥草、桑白皮、桃仁、苍耳子、辛夷、桔梗、菟丝子、补骨脂按一定重量配比制备而成,本发明药物具有祛风通窍,泻肺平喘,祛风燥湿的功效,用于治疗鼻炎见效快,疗程短,无毒副作用。

Description

一种治疗鼻炎的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗鼻炎的药物及其制备方法,属中药领域。 技术背景
[0002] 鼻炎指的是鼻腔粘膜和粘膜下组织的炎症。表现为充血或者水肿,患者经常会出 现鼻塞,流清水涕,鼻痒,喉部不适,咳嗽等症状。鼻炎不单只是影响鼻子,同时还会影响咽 喉和眼睛。它还会影响人的睡眠质量、听力以及学习能力。目前,西药治疗鼻炎效果不佳, 且长期服用西药有较多副作用,因此,人们对快速有效治疗鼻炎的中药存在很大的需求。
发明内容
[0003] 本发明人依据中医理论的研究及临床反复的试验和验证,终于找到了有效治疗鼻 炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种能够有效治疗鼻炎的组合药物。
[0005] 本发明的另一个目的就是提供了该组合药物的制备方法。
[0006] 本发明药物是选用黄芪、白术、防风、鱼腥草、桑白皮、桃仁、苍耳子、辛夷、桔梗、菟 丝子、补骨脂、石菖蒲、丹参、白龙、五味子、细辛、甘草、党参、川;、赤巧、蝶脱、陈皮药物进 行组合的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗鼻炎的复发。 其中选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的 功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾 虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用白术是因为其性味苦甘,温,入 脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰 饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用防风是因为其性味辛甘,温,入 膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹, 骨节酸痛,四肢挛急,破伤风。选用鱼腥草是因为其性味辛,寒,入手太阴经,有清热解毒, 利尿消肿的功能,治肺炎,肺脓疡,热痢,疟疾,水肿,淋病,白带,痈肿,痔疮,脱肛,湿疹,秃 疮,疥癣。选用桑白皮是因为其性味甘,寒,入肺、脾经,有泻肺平喘,行水消肿的功能,治肺 热喘咳,吐血,水肿,脚气,小便不利。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有 破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥 便秘。选用苍耳子是因为其性味甘,温,有毒,入肺、肝经,有散风,止痛,祛湿,杀虫的功能, 治风寒头痛,鼻渊,齿痛,风寒湿痹,四脚挛痛,疥癞,瘙痒。选用辛夷是因为其性味辛,温, 入肺、胃经,有祛风,通窍的功能,治头痛,鼻渊,鼻塞不通,齿痛。选用桔梗是因为其性味苦 辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁 痛,痢疾腹痛。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功 能,治腰膝酸痛,遗精,消渴,尿有余浙,目暗。选用补骨脂是因为其性味辛,温,入肾经,有补 肾助阳的功能,治肾虚冷泻,遗尿,滑精,小便频数,阳痿,腰膝冷痛,虚寒喘嗽,外用治白癜 风。选用石菖蒲是因为其性味辛苦,微温,入心、肝、脾经,有开鸾,豁痰,理气,活血,散风, 去湿的功能,治癫癎,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈 疽肿毒,跌打损伤。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排 脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼 痛,惊悸不眠,恶疮肿毒。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿, 止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤 燥痒,疥癣。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的 功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用细辛是因为 其性味辛,温,入肺、肾经,有祛风,散寒,行水,开窃的功能,治风冷头痛,鼻渊,止痛,痰饮咳 逆,风湿痹痛。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸 药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心t季,惊痈,生用治咽喉 肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用党参是因为其性味甘,平,入手、足太 阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱 肛。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治 风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用赤芍是因为 其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛, 肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用蝉蜕是因为其性味甘咸,凉,入 肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小 儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理 气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。
[0007] 本发明组合的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好疗效 黄芪 20-25克 白术 15-20克 防风 15-20克 鱼腥草 15-20克 桑白皮 15-20克 桃仁 15-20克 苍耳子 10-15克 辛夷 10-15克 桔梗 10-15克 菟丝子 10-15克 补骨脂 10-15克 石菖蒲 10-15克 丹参 10-15克 白芷 5-10克 五味子 5-10克 细辛 5-10克 甘草 5-10克 党参 5-10克 川芎 5-10克 赤芍 5-10克 蝉蜕 3-5克 陈皮 3-5克 优选用量为 黄芪 23克 白术 18克 防风 18克 鱼腥草 18克 桑白皮 18克 桃仁 18克 苍耳子 13克 辛夷 13克 桔梗 13克 菟丝子 13克 补骨脂 13克 石菖蒲 13克 丹参 13克 白芷 7克 五味子 7克 细辛 7克 甘草 7克 党参 7克 川芎 7克 赤芍 7克 蝉蜕 4克 陈皮 4克 本发明药物的制备方法如下 一、备料 1、 黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切 片,晒干; 2、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 3、 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; 4、 鱼腥草:去净杂质,除去残根,洗净切段,晒干; 5、 桑白皮:刷去灰屑,洗净,润透后切丝,晒干; 6、 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干, 簸净; 7、 苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉; 8、 辛夷:拣净枝梗杂质,捣碎用; 9、 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; 10、 菟丝子:过萝去净杂质,洗净,晒干; 11、 补骨脂:簸净杂质,洗净,晒干; 12、 石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干; 13、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 14、 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; 15、 五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干; 16、 细辛:除净杂质,用水喷润,及时切段,晒干; 17、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 18、 党参:洗净泥沙后润透去芦,切片或切段,晒干; 19、 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; 20、 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑; 21、 蝉蜕:拣去杂质,洗净晒干; 22、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰屑。
[0008] 二、制备 1、将所述重量的黄芪、白术、防风、鱼腥草、桑白皮、桃仁、苍耳子、辛夷、桔梗、菟丝子、 补骨脂、石菖蒲、丹参、白芷、五味子、细辛、甘草、党参、川芎、赤芍、蝉蜕、陈皮药物加6倍量 水进行浸泡,浸泡150分钟后,武火煎煮沸腾30分钟,再用文火煎煮30分钟过滤,将第一次 煎煮液倒入容器内。
[0009] 2、将过滤的药渣加水5倍量,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第二次 煎煮液。
[0010] 3、将两次煎煮液混合,再用文火煮10分钟即得煎煮药液,将煎煮液分为4剂服用。
[0011] 本发明选用辛夷为君药,桔梗、川芎为臣药,赤芍为佐药,甘草为使药,将上述药物 与方中诸药组合,使得各药物功效相互协同,制成治疗鼻炎的药物。
[0012] 本发明药物具有祛风通窍,泻肺平喘,祛风燥湿的功效,用于治疗鼻炎,疗程短、见 效快、治愈后不复发、无毒副作用。
[0013]
具体实施方式: 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括了本发明 药物的动物毒性试验报告和临床观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告 取家兔30只,雌雄兼用,体重2. 0 - 2. 5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天2次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物治疗鼻炎的临床观察资料 1、一般资料 收治门诊患者共36例。
[0016] 2、诊断标准 症状 (1)鼻塞:鼻塞特点为间歇性。在白天、天热、劳动或运动时鼻塞减轻,而夜间,静坐或 寒冷时鼻塞加重。鼻塞的另一特点为交替性。如侧卧时,居下侧之鼻腔阻塞,上侧鼻腔通气 良好。由于鼻塞,间或有嗅觉减退、头痛、头昏、说话呈闭塞性鼻音等症状。
[0017] (2)多涕:常为黏液性或黏脓性,偶成脓性。脓性多于季发性感染后出现。
[0018] (3)嗅觉下降:多为两种原因所致,一为鼻黏膜肿胀、鼻塞,气流不能进入嗅觉区 域;二为嗅区黏膜受慢性炎症长期刺激,嗅觉功能减退或消失。
[0019] (4)头痛、头昏:慢性鼻窦炎多表现为头沉重感。
[0020] (5)全身表现:多数人有头痛、食欲不振、易疲倦、记忆力减退及失眠等。
[0021] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续 服用4个疗程。
[0022] 4、疗效评定标准 显效:鼻炎症状消失,疮愈,体质恢复正常; 好转:鼻炎症状明显好转,头痛鼻塞症状减轻,流涕症状得到控制; 无效:达不到好转标准者。
[0023] 5、治疗结果(见下表)
Figure CN104474174AD00071
在上述的治疗中,用本发明药物治疗鼻炎患者36例,结果显效5例,显效率为83. 33%, 好转5例,好转率为13. 89%,无效1例,总有效率为97. 22%。

Claims (3)

1. 一种治疗鼻炎的药物,其特征求在于:它是由下列重量范围内的原料药制成: 黄芪20-25克白术15-20克防风15-20克 鱼腥草15-20克 桑白皮15-20克 桃仁15-20克 苍耳子10-15克 辛夷10-15克 桔梗10-15克 菟丝子10-15克补骨脂10-15克石菖蒲10-15克 丹参10-15克白芷5-10克五味子5-10克 细辛5-10克甘草5-10克党参5-10克 川芎5-10克赤芍5-10克蝉蜕3-5克 陈皮3-5克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 黄芪23克白术18克防风18克 鱼腥草18克桑白皮18克桃仁18克 苍耳子13克辛夷13克桔梗13克 菟丝子13克补骨脂13克石菖蒲13克 丹参13克 白芷7克 五味子7克 细辛7克 甘草7克 党参7克 川芎7克 赤芍7克 蝉蜕4克 陈皮4克。
3. 根据权利要求1或2所述药物的制备方法,其特征在于:它包括下列步骤: (一)备料 (1) 黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切 片,晒干; (2) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (3) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (4) 鱼腥草:去净杂质,除去残根,洗净切段,晒干; (5) 桑白皮:刷去灰屑,洗净,润透后切丝,晒干; (6) 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒 干,簸净; (7) 苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉; (8) 辛夷:拣净枝梗杂质,捣碎用; (9) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (10) 菟丝子:过萝去净杂质,洗净,晒干; (11) 补骨脂:簸净杂质,洗净,晒干; (12) 石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干; (13) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (14) 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; (15) 五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干; (16) 细辛:除净杂质,用水喷润,及时切段,晒干; (17) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; (18) 党参:洗净泥沙后润透去芦,切片或切段,晒干; (19) 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; (20) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑; (21) 蝉蜕:拣去杂质,洗净晒干; (22) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰屑; (二)制备 (1) 将所述重量的黄芪、白术、防风、鱼腥草、桑白皮、桃仁、苍耳子、辛夷、桔梗、菟丝子、 补骨脂、石菖蒲、丹参、白芷、五味子、细辛、甘草、党参、川芎、赤芍、蝉蜕、陈皮药物加6倍量 水进行浸泡,浸泡150分钟后,武火煎煮沸腾30分钟,再用文火煎煮30分钟过滤,将第一次 煎煮液倒入容器内; (2) 将过滤的药渣加水5倍量,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第二次煎 煮液; (3) 将两次煎煮液混合,再用文火煮10分钟即得煎煮药液。
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