CN104474167A - Jiuerxin capsules and preparation method thereof - Google Patents
Jiuerxin capsules and preparation method thereof Download PDFInfo
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- CN104474167A CN104474167A CN201410703484.6A CN201410703484A CN104474167A CN 104474167 A CN104474167 A CN 104474167A CN 201410703484 A CN201410703484 A CN 201410703484A CN 104474167 A CN104474167 A CN 104474167A
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- jiuerxin
- capsules
- carbon dioxide
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- extracting solution
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- 239000002775 capsule Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 28
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 16
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 14
- 239000001569 carbon dioxide Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 241000180649 Panax notoginseng Species 0.000 claims description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 206010002383 Angina Pectoris Diseases 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000029078 coronary artery disease Diseases 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 239000002994 raw material Substances 0.000 abstract description 3
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 230000010354 integration Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000093833 Aristolochia contorta Species 0.000 description 1
- 241000046617 Aristolochia debilis Species 0.000 description 1
- 241000758795 Aristolochiaceae Species 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241001632410 Eleutherococcus senticosus Species 0.000 description 1
- 241000244355 Ligusticum Species 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Jiuerxin capsules and a preparation method thereof. The Jiuerxin capsules are characterized by being prepared by taking 57g of herba aristolochiae, 134g of pseudo-ginseng, 335g of ligusticum wallichii, 67g of rhizoma alismatis and 300g of acanthopanax, extracting the raw materials by a supercritical carbon dioxide extraction method, drying the extract under a reduced pressure, crushing the extract into a dry nano-paste by a high-energy nano-impact mill, and adding functional auxiliary materials. The disintegration time of the Jiuerxin capsules is remarkably shortened, the curative effect is remarkably superior to that of commercially available Jiuerxin capsules, and active effects are obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Jiuerxin capsules and preparation method thereof.
Background technology
Jiuerxin capsules blood circulation and channel invigorating, blood stasis dispersing and fresh blood promoting.For coronary heart disease, angina pectoris.Commercially available Jiuerxin capsules is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Jiuerxin capsules that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30 ~ 40Mpa, extraction temperature 30 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 50 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 40 ~ 50L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained Jiuerxin capsules 1000.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Herba Aristolochiae: China's coastal port one ministerial standard.This product is the dry aerial parts of aristolochiaceae plant Fructus Aristolochiae Aristolochia debilis Sieb.etZucc. or Aristolochia contorta Aristolachia contorta Bge..Autumn taps, and removing impurity, dries.
Radix Notoginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of panax araliaceae plant Punax notoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanriong Hort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Rhizoma Alismatis: China's coastal port one ministerial standard.This product is Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis(Sam.) dry tuber of Juzep..Excavate when winter, stem and leaf started withered, cleaning, drying, removing fibrous root and rough bark.
Radix Et Caulis Acanthopanacis Senticosi: China's coastal port one ministerial standard.This product is Araliaceae Radix Et Caulis Acanthopanacis Senticosi Acanthopanax senticosus(Ru-pr. et Maxim.) the dry root and rhizome of Harms or stem.Spring, Qiu Erji gather, cleaning, drying.
Calcium sulfate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above Jiuerxin capsules all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 10Mpa, separator temperature 50 DEG C, disengaging time 2 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, incapsulates, obtained Jiuerxin capsules 1000.
Specific embodiments of the invention 2
Get Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 20Mpa, separator temperature 60 DEG C, disengaging time 4 hours, carbon dioxide flow 50L per hour, obtains extracting solution; Get extracting solution 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, incapsulates, obtained Jiuerxin capsules 1000.
Specific embodiments of the invention 3
Get Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 35Mpa, extraction temperature 35 DEG C, separator pressure 15Mpa, separator temperature 55 DEG C, disengaging time 3 hours, carbon dioxide flow 45L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained Jiuerxin capsules 1000.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Jiuerxin capsules.Actual effect of the present invention is investigated below with the Jiuerxin capsules that embodiment 3 is obtained:
(1) embodiment 3 Jiuerxin capsules and contrast disintegration of commercially available Jiuerxin capsules
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 Jiuerxin capsules and commercially available Jiuerxin capsules contrast table disintegration
The above results shows, Jiuerxin capsules prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available Jiuerxin capsules.
(2) embodiment 3 Jiuerxin capsules and commercially available Jiuerxin capsules treat angina pectoris Disease Clinical observation of curative effect
1 case scenario
Statistics outpatient service and inpatient, observe angina pectoris disease case 110 example, 60 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 Jiuerxin capsules, and matched group takes commercially available Jiuerxin capsules.
2 efficacy assessment standards
According to new Chinese medicine treatment angina pectoris guideline of clinical investigations tcm syndrome curative effect determinate standard:
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Increase the weight of: tcm clinical practice symptom, sign all have and increase the weight of, syndrome integral reduces < 0.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 Jiuerxin capsules and commercially available Jiuerxin capsules clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, Jiuerxin capsules prepared by the present invention is when treating angina pectoris disease, evident in efficacy higher than commercially available Jiuerxin capsules, p < 0.05.
Claims (3)
1. treat a coronary heart disease, the Chinese medicine of angina pectoris disease, is characterized in that getting Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 30 ~ 40Mpa, extraction temperature 30 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 50 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 40 ~ 50L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained Jiuerxin capsules.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30 ~ 40Mpa, extraction temperature 30 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 50 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 40 ~ 50L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained Jiuerxin capsules.
3. the preparation method of Chinese medicine according to claim 1, gets Herba Aristolochiae 57g, Radix Notoginseng 134g, Rhizoma Chuanxiong 335g, Rhizoma Alismatis 67g, Radix Et Caulis Acanthopanacis Senticosi 300g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 35Mpa, extraction temperature 35 DEG C, separator pressure 15Mpa, separator temperature 55 DEG C, disengaging time 3 hours, carbon dioxide flow 45L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add calcium sulfate 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained Jiuerxin capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410703484.6A CN104474167A (en) | 2014-11-30 | 2014-11-30 | Jiuerxin capsules and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410703484.6A CN104474167A (en) | 2014-11-30 | 2014-11-30 | Jiuerxin capsules and preparation method thereof |
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| Publication Number | Publication Date |
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| CN104474167A true CN104474167A (en) | 2015-04-01 |
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| CN201410703484.6A Pending CN104474167A (en) | 2014-11-30 | 2014-11-30 | Jiuerxin capsules and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600234A (en) * | 2012-04-13 | 2012-07-25 | 孙长海 | Swertia mileensis dispersible tablet and preparation method thereof |
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- 2014-11-30 CN CN201410703484.6A patent/CN104474167A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600234A (en) * | 2012-04-13 | 2012-07-25 | 孙长海 | Swertia mileensis dispersible tablet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵国华等: "《最新中成药手册》", 30 September 1998, 中原农民出版社 * |
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