CN104459172B - A kind of automatization's sample of bone marrow processing means and automated analysis, diagosis method - Google Patents

A kind of automatization's sample of bone marrow processing means and automated analysis, diagosis method Download PDF

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CN104459172B
CN104459172B CN201410697900.6A CN201410697900A CN104459172B CN 104459172 B CN104459172 B CN 104459172B CN 201410697900 A CN201410697900 A CN 201410697900A CN 104459172 B CN104459172 B CN 104459172B
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sample
computer
bone marrow
automatic
holding wire
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CN201410697900.6A
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CN104459172A (en
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孙小蓉
庞宝川
郑飞
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武汉兰丁医学高科技有限公司
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Abstract

The present invention relates to a kind of automatization's sample of bone marrow processing means and automated analysis, diagosis method, automatic staining technology, sample quality Automatic Measurement Technique, encryption technology, microtechnique and image processing techniques are combined by it, it is possible to achieve dye, scan, diagosis Omnibearing automatic.In automatization's diagosis method, first the full scan sample of low power lens and splicing are carried out, obtain low power lens bulk sample panorama sketch originally, then input feature of interest parameter set, finally carry out scanning and the splicing of high power lens area-of-interest, obtain high power lens area-of-interest panorama atlas, process with tradition sample of bone marrow and compare with diagosis method, solve doctor and cannot check the problem of whole sample of bone marrow quality on the whole, improve speed and the accuracy rate of doctor's diagosis.Low power lens panorama sketch and high power lens panorama atlas that the present invention obtains can be as the objective basis of clinical diagnosis and experimental datas, and the development for myelopathy diagnostics provides necessary support, and social benefit is huge.

Description

A kind of automatization's sample of bone marrow processing means and automated analysis, diagosis method

Technical field

The present invention relates to a kind of automatization's sample of bone marrow processing means and automated analysis, diagosis method, belong to biological Medical treatment detection analytical tool and method and technology field, particularly to human marrow sample processing means and automated analysis, read Sheet method.

Background technology

Blood cell morphology inspection is the big event of the diagnosis of hematopathy basis and routine hematology inspection, is most basic Simple and practical inspection method.Blood cell morphology inspection mainly includes that bone marrow and peripheral blood cells form check two parts.Blood The height of morphocytology quality inspection is the most hemopathic prevention of numerous disease, diagnosis, Differential Diagnosis and Index for diagnosis Key.But in clinical practice diagnoses, often lack unified standard test method and test condition, and due to experiment Room reviewer's quality is different, and testing result often exists subjectivity, one-sidedness, lacks objective diagnosis data etc., for facing Bed diagnosis and treatment work is negatively affected.Especially Morphology of Bone Marrow is complicated, and diagnostic personnel is carried by the diagosis for medullary cell Go out more strict requirements.

The dyeing work of traditional sample of bone marrow, Sample job demand staff are artificially carried out, at dyeing course In, need doctor oneself the estimation time, after sample completes dyeing, in addition it is also necessary to staff carries out sample according to subjective standard Quality testing, causes inefficiency, and accuracy rate is the highest.According to the standard operation requirement of clinical diagnosis, inspection doctor is thin to bone marrow The diagnosis of born of the same parents has generally required the morphological analysis of more than 500 nucleated cell, it is therefore desirable to inspection doctor is the most artificial Operation, is easily caused diagnosis efficiency low, and waste of manpower resource.It addition, traditional sample of bone marrow diagosis needs manually completely Carrying out, first doctor to select area-of-interest under low power lens, and then mobile platform carries out high power lens scanning to this region, as Really area-of-interest is too much, and doctor will repeatedly carry out the switching of high low power lens, so significantly impacts efficiency, and through too much Sub-region selects, and area-of-interest cannot be concentrated and analyze by doctor on the whole, so can reduce accuracy rate of diagnosis.Granted publication The patent of number CN 1296699C disclose a kind of micro-multispectral bone marrow and peripheral blood cells automatic analyzer and analyze bone marrow and The method of peripheral blood cells, but this spectrum analysis process image process is the most complicated, the longest, be not suitable for clinical practice, and should Automatic analyzer only achieves scanning, image analysis processing automatization, at the detection of unrealized sample dyeing, sample quality, image The Omnibearing automatic of the sub-scannings such as reason.It addition, patent CN 101407759A " cellanalyzer and the method for analysis " and special Profit CN 103604737A " a kind of automatization's blood cell recognition device and method of work " is all around the automatization of scan sample and enters Row, and all use artificially colored, manual quality's inspection, the blood cell sample roadmap that thoroughly breakthrough is traditional yet, therefore, Clinical Laboratory doctor's urgent needs can have automatic staining, automatically detect sample quality, automatically analyzes, reads medullary cell shape The full-automatic device that state is integrated, adjuvant clinical doctor completes the diagnosis of medullary cell sample, and reservation objectively diagnoses data.

Summary of the invention

In order to overcome the defect of prior art, solving above-mentioned technical problem, the present invention provides a kind of automatization sample of bone marrow Processing means and automated analysis, diagosis method, it by automatic staining technology, sample quality Automatic Measurement Technique, encryption technology, Microtechnique and image processing techniques combine, it is possible to achieve dye, scan, diagosis automatization.Process with tradition sample of bone marrow Comparing with diagosis method, efficiency and accuracy rate are greatly improved, low power lens panorama sketch that the present invention obtains and high power lens panorama atlas Can be as the objective basis of clinical diagnosis and experimental data, the development for myelopathy diagnostics provides necessary support, society Benefit.

The present invention relates to a kind of automatization sample of bone marrow processing means, it is achieved in that it includes that automatic staining fills Put (2), sample quality detection device (4), microscope (5) and computer (10);It is characterized in that:

A, having a timekeeping system (1), its core component is timer (11), and it is arranged on automatic staining device (2), And by the communication interface of holding wire connection computer (10), for the calculating to sample of bone marrow dyeing time, and pass through in real time Holding wire transmission dyeing time data are to computer (10);

B, having a warning system (3), its core component is alarm (12) and high-definition camera (13), alarm (12) On red light and green light are installed, warning system (3) is arranged on sample quality detection device (4), and connects meter by holding wire The communication interface of calculation machine (10);

C, having an encryption system (6), its core component is barcode scanner (7), and it is arranged on microscope (5), and By holding wire connect computer (10) communication interface and automatic carrier (9) in automatic carrier control system (14);

D, having an object lens converting system (8), it is arranged on microscope (5), and computer (10) is by changing object lens The control of system (8), it is achieved high power objective and the switching of low power objective.

Preferably, the frequency of timer (11) is 1000HZ.

Preferably, the scanning height of bar code scan instrument (9) is 4cm, and sweep limits is 5cm*5cm.

Preferably, the rotational angle of object lens converting system (8) is 360 degree.

It addition, present invention also offers the analysis method of a kind of automatization sample of bone marrow processing means, comprise the following steps:

(1) during sample of bone marrow is placed on automatic staining device (2) by operator, and the software system on computer (10) is opened System;

(2) computer (10) control automatic staining device (2) starts to dye sample;

(3) automatic staining device (2) passes through the holding wire real-time Transmission dyeing time data of timekeeping system (1) to computer (10), automatic staining device (2) is controlled by computer (10) by time data: computer (10) is according to the time of dyeing Parameter, it is judged that whether automatic staining device (2) reaches standard-required to the dyeing time of sample of bone marrow, and is transmitted by holding wire Order data, to timekeeping system (1), controls restarting and stopping of timekeeping system (1), and timekeeping system (1) obtains computer (10) After restarting and ceasing and desisting order, control automatic staining device (2) and start and stop;

(4), after having dyeed, sample is placed in sample quality detection device (4) by operator, and computer (10) passes through Holding wire controls sample testing apparatus and starts to detect sample, and sample testing apparatus (4) passes through holding wire real-time Transmission sample image To computer (10);

(5) warning system (3) is configured by computer (10) by sample image data: when sample quality detecting system (4), when detecting sample of bone marrow, the high-definition camera (13) in warning system (3) captures the image information of sample, and By warning system (3) transmission image information to computer (10), after image information analyzed by computer (10), it is calculated image Grey scale difference data, and make comparisons with standard-required, if reaching requirement, computer (10) transmits "Yes" by holding wire Order is to warning system (3), after warning system (3) receives "Yes" order, controls the green light flicker on alarm (12);Instead It, when sample image do not reach require time, computer (10), is reported to the police to warning system (3) by holding wire transmission "No" order After system (3) receives "No" order, control the blinking red lamp on alarm (12), thus realize the automatic inspection of sample quality Survey;

(6) after sample quality detection is qualified, sample is placed on automatic carrier (9) by operator, and encryption system (6) leads to Cross holding wire and the bar code information on sample is transferred to computer (10);

(7) encryption system (6) is controlled by computer (10) by bar code information: start to scan it at sample of bone marrow Before, after computer (10) transmits commands to encryption system (6) by holding wire, encryption system (6) is by holding wire transmission order Lock automatic carrier (9) to automatic carrier control system (14), and control the bar code in barcode scanner (7) scanned samples Information, is transferred to computer (10) by holding wire, and computer (10) is analyzed after obtaining bar code information, obtains in information Encryption data, and compare with normal data, if conformance with standard data demand, computer (10) is by holding wire transmission life Making to encryption system (6), encryption system (6) transmits commands to automatic carrier control system (14) by holding wire, unlocks certainly Dynamic object stage (9);

(8) encryption is by rear, starts scanned samples, i.e. diagosis: comprise the following steps:

A microscope (5) scans above-mentioned sample of bone marrow under low power lens, and scanning M row, N row, obtain continuous print M continuously Row, N row cyclogram, form atlas A;

B utilizes image split-joint method, and above-mentioned atlas A is combined as panorama sketch I;

C determines that area-of-interest (ROI) selects set of eigenvectors V;

D, according to selecting set of eigenvectors V to process panorama sketch I, finds area-of-interest collection S{s1, s2 ... .Sn};

E utilizes the computer (10) control to object lens converting system (8), and microscopical low power objective is switched to high power Object lens, then under high power lens, scanning area-of-interest collection Si(i belongs to [1, n] successively), for each area-of-interest, Scanning Mi row, Ni arrange (i belongs to [1, n]) continuously, and composition visual field atlas Bi(i belongs to [1, n]), finally obtain cyclogram set B B1 ... .Bn};

F, to each visual field atlas Bi, utilizes image split-joint method, is combined as panorama sketch Ki, finally obtain panorama atlas Close K{K1. ... .Kn}.

The region of described low power lens scanned samples is bulk sample one's respective area, and it is selected region with traditional doctor and compare, has More fully data support.

Described area-of-interest characteristic parameter collection, is obtained by Study first training, and dimensional extent is variable, with traditional master Sight characteristic parameter is compared, and this feature parameter set possesses stability, repeatability and accuracy.

Described low power lens panorama sketch is foundation and the training area-of-interest characteristic parameter collection that doctor carries out pathological diagnosis Data source.

Described high power lens panorama atlas is the data source extracting medullary cell image.

Compared with prior art, a kind of automatization sample of bone marrow processing means that the present invention relates to and analysis, diagosis side Method, has the following advantages and significantly improves:

1, the automatic staining device using timekeeping system to control, can break through traditional artificially colored method, time-saving and efficiency;

2, use the sample quality detection device that warning system controls, solve the subjective criterion of hand inspection sample quality Uncertain problem, introduces objective criterion, improves accuracy rate;

3, in diagosis method, the full scan sample of low power lens and splicing, then input feature of interest parameter set are first carried out, Finally carry out scanning and the splicing of high power lens area-of-interest, obtain high power lens area-of-interest panorama atlas, solve doctor The problem that cannot check whole sample of bone marrow quality on the whole, improves speed and the accuracy rate of doctor's diagosis.

4, have employed encryption system, data analysis is safe and reliable.

Accompanying drawing explanation

Fig. 1 is the schematic diagram of whole automatization sample of bone marrow processing means, wherein, 1-timekeeping system, and 2-automatic staining fills Putting, 3-warning system, 4-sample quality detection device, 5-microscope, 6-encryption system, 7-barcode scanner, 8-object lens are changed System, 9-automatic carrier, 10-computer, 11-timer, 12-alarm, 13-high-definition camera, 14-automatic carrier control System processed.

Fig. 2 is the workflow diagram of present invention microscope scanning diagosis.

Fig. 3 is a width typical bone marrow image.

Fig. 4 be image mosaic be the schematic diagram of panorama sketch.

Detailed description of the invention

The present invention is described in detail in conjunction with the embodiments.It should be understood that following example are only to embodiment party of the present invention The illustration of formula, rather than the scope of the present invention is limited.

Embodiment 1:

Below in conjunction with the accompanying drawings technical scheme is described further as follows:

Fig. 1 is an embodiment of a kind of automatization of present invention sample of bone marrow processing means.

It includes automatic staining device (2), sample quality detection device (4), microscope (5) and computer (10);Also have: A, having a timekeeping system (1), its core component is timer (11), and it is arranged on automatic staining device (2), and by letter Number line connects the communication interface of computer (10), for the calculating to sample of bone marrow dyeing time, and is passed by holding wire in real time Defeated dyeing time data are to computer (10);B, having a warning system (3), its core component is alarm (12) and high definition is taken the photograph As head (13), alarm (12) being provided with red light and green light, warning system (3) is arranged on sample quality detection device (4), And the communication interface of computer (10) is connected by holding wire;C, having an encryption system (6), its core component is bar code scan Device (7), it is arranged on microscope (5), and is connected communication interface and the automatic carrier control of computer (10) by holding wire System processed (14);D, having an object lens converting system (8), it is arranged on microscope (5), and computer (10) is by turning object lens Change the control of system (8), it is achieved high power objective and the switching of low power objective.

Fig. 2,3,4 are by automatization of the present invention sample of bone marrow processing means analysis, the method for diagosis sample of bone marrow Embodiment:

First during sample of bone marrow is placed on automatic staining device (2) by operator, and the software system on computer (10) is opened System, then computer (10) control automatic staining device (2) starts to dye sample, and automatic staining device (2) is by meter Time system (1) holding wire real-time Transmission dyeing time data to computer (10), computer (10) by time data to from Dynamic dyeing apparatus (2) is controlled: computer (10) is according to the time parameter of dyeing, it is judged that automatic staining device (2) is to bone marrow Whether the dyeing time of sample reaches standard-required, and by holding wire command data to timekeeping system (1), controls timing The restarting and stop of system (1), after timekeeping system (1) obtains the restarting and cease and desist order of computer (10), controls automatic staining Device (2) starts and stops;After having dyeed, sample is placed in sample quality detection device (4) by operator, computer (10) controlling sample testing apparatus by holding wire and start to detect sample, sample testing apparatus (4) passes through holding wire real-time Transmission Sample image is to computer (10);Warning system (3) is configured by computer (10) by sample image data: when sample matter When sample of bone marrow is detected by amount detection systems (4), the high-definition camera (13) in warning system (3) captures the figure of sample As information, and by warning system (3) transmission image information to computer (10), after image information analyzed by computer (10), meter Calculating the grey scale difference data obtaining image, and make comparisons with standard-required, if reaching requirement, computer (10) passes through signal Line transmission "Yes" order is to warning system (3), and after warning system (3) receives "Yes" order, control on alarm (12) is green Lamp flashes;Otherwise, when sample image do not reach require time, computer (10) by holding wire transmission "No" order to warning system (3), after warning system (3) receives "No" order, control the blinking red lamp on alarm (12), thus realize sample quality Automatically detection;After sample quality detection is qualified, sample is placed on automatic carrier (9) by operator, and encryption system (6) passes through Bar code information on sample is transferred to computer (10) by holding wire;Then computer (10) passes through bar code information to encryption system (6) it is controlled: before sample of bone marrow starts scanning, computer (10) transmits commands to encryption system (6) by holding wire After, encryption system (6) transmits commands to automatic carrier control system (14) by holding wire and locks automatic carrier (15), and Control the bar code information in barcode scanner (7) scanned samples, and be transferred to computer (10), computer (10) by holding wire It is analyzed after obtaining bar code information, obtains the encryption data in information, and compare with normal data, if conformance with standard Data demand, computer (10) transmits commands to encryption system (6) by holding wire, and encryption system (6) is transmitted by holding wire Order to automatic carrier control system (14), unlock automatic carrier (9);Finally encrypt by rear, start scanned samples, i.e. Diagosis.

Fig. 2 is the workflow diagram of present invention microscope scanning diagosis, comprises the following steps: first exist with microscope (5) Scanning above-mentioned sample of bone marrow under low power lens, scanning M row, N row, obtain continuous print M row, N row cyclogram, form atlas A continuously;Again Utilize image split-joint method, above-mentioned atlas A is combined as panorama sketch I;It is then determined that area-of-interest (ROI) select feature to Quantity set V, according to selecting set of eigenvectors V to process panorama sketch I, finds area-of-interest collection S{s1, and s2 ... .Sn}, followed by meter The calculation machine (10) control to object lens converting system (8), is switched to existing high power objective by microscopical low power objective, then in high power Under mirror, scanning area-of-interest collection Si(i belongs to [1, n] successively), for each area-of-interest, scanning Mi row, Ni continuously Row (i belongs to [1, n]), composition visual field atlas Bi(i belongs to [1, n]), obtain cyclogram set B{B1 ... .Bn}, then to often One visual field atlas Bi, utilizes image split-joint method, is combined as panorama sketch Ki, finally obtains panorama sketch set K{K1. ... .Kn}.

Fig. 3 is a width typical bone marrow field-of-view image.

Fig. 4 is the process instance of image mosaic.Image 1 ~ 4 is the bone marrow image of adjacent fields, 5 be image 1 ~ 4 splicing and The image become.

Claims (6)

1. the automatic partition analysis method of automatization's sample of bone marrow processing means, it is characterised in that: the method includes following step Rapid:
(1) during sample of bone marrow is placed on automatic staining device (2) by operator, and the software system on computer (10) is opened;
(2) computer (10) control automatic staining device (2) starts to dye sample;
(3) automatic staining device (2) passes through the holding wire real-time Transmission dyeing time data of timekeeping system (1) to computer (10), automatic staining device (2) is controlled by computer (10) by time data: computer (10) is according to the time of dyeing Parameter, it is judged that whether automatic staining device (2) reaches standard-required to the dyeing time of sample of bone marrow, and is transmitted by holding wire Order data, to timekeeping system (1), controls restarting and stopping of timekeeping system (1), and timekeeping system (1) obtains computer (10) After restarting and ceasing and desisting order, control automatic staining device (2) and start and stop;
(4), after having dyeed, sample is placed in sample quality detection device (4) by operator, and computer (10) passes through signal Line traffic control sample testing apparatus starts to detect sample, and sample testing apparatus (4) gives meter by holding wire real-time Transmission sample image Calculation machine (10);
(5) warning system (3) is configured by computer (10) by sample image data: when sample quality detecting system (4) When detecting sample of bone marrow, the high-definition camera (13) in warning system (3) captures the image information of sample, and passes through Warning system (3) transmission image information, to computer (10), after image information analyzed by computer (10), is calculated the ash of image Degree standard deviation data, and make comparisons with standard-required, if reaching requirement, computer (10) transmits "Yes" order by holding wire To warning system (3), after warning system (3) receives "Yes" order, control the green light flicker on alarm (12);Otherwise, when Sample image does not reaches when requiring, computer (10) transmits "No" order to warning system (3), warning system by holding wire (3), after receiving "No" order, control the blinking red lamp on alarm (12), thus realize the automatic detection of sample quality;
(6) after sample quality detection is qualified, sample is placed on automatic carrier (9) by operator, and encryption system (6) is by letter Bar code information on sample is transferred to computer (10) by number line;
(7) encryption system (6) is controlled by computer (10) by bar code information: before sample of bone marrow starts scanning, meter After calculation machine (10) transmits commands to encryption system (6) by holding wire, encryption system (6) is transmitted commands to by holding wire automatically Object stage control system (14) locks automatic carrier (9), and controls the bar code information in barcode scanner (7) scanned samples, Being transferred to computer (10) by holding wire, computer (10) is analyzed after obtaining bar code information, obtains the encryption in information Data, and compare with normal data, if conformance with standard data demand, computer (10) is transmitted commands to by holding wire Encryption system (6), encryption system (6) transmits commands to automatic carrier control system (14) by holding wire, unlocks from dynamic load Thing platform (9);
(8) encryption is by rear, starts scanned samples, i.e. diagosis.
Automatic partition analysis method the most according to claim 1, it is characterised in that: the diagosis in described step (8) include with Lower step:
A microscope (5) scans above-mentioned sample of bone marrow under low power lens, continuously scanning M row, N row, obtains continuous print M row, N row Cyclogram, forms atlas A;
B utilizes image split-joint method, and above-mentioned atlas A is combined as low power lens panorama sketch I;
C determines area-of-interest (ROI) set of eigenvectors V;
D processes panorama sketch I according to set of eigenvectors V, finds area-of-interest collection S{s1, s2 ..., Sn};
E utilizes the computer (10) control to object lens converting system (8), and microscopical low power objective is switched to high power objective, Then, under high power lens, scanning area-of-interest collection Si (i belongs to [1, n]), for each area-of-interest, sweeps continuously successively Retouch Mi row, Ni arranges (i belongs to [1, n]), composition visual field atlas Bi (i belongs to [1, n]), finally obtains cyclogram set B{B1 ..., Bn};
F, to each visual field atlas Bi, utilizes image split-joint method, is combined as panorama sketch Ki, finally obtains panorama sketch set K {K1,…,Kn}。
Automatic partition analysis method the most according to claim 2, it is characterised in that the region of described low power lens scanned samples For bulk sample one's respective area.
Automatic partition analysis method the most according to claim 2, it is characterised in that described area-of-interest characteristic parameter Collection, is obtained by Study first training, and dimensional extent is variable.
Automatic partition analysis method the most according to claim 2, it is characterised in that low power lens panorama sketch is that doctor carries out pathology The foundation of diagnosis and the data source of training area-of-interest characteristic parameter collection.
Automatic partition analysis method the most according to claim 2, it is characterised in that high power lens panorama atlas is that extraction bone marrow is thin The data source of born of the same parents' image.
CN201410697900.6A 2014-11-28 2014-11-28 A kind of automatization's sample of bone marrow processing means and automated analysis, diagosis method CN104459172B (en)

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