CN104436142B - 一种治疗猪流行性腹泻的中药组合物 - Google Patents
一种治疗猪流行性腹泻的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种治疗猪流行性腹泻的中药组合物由以重量份配比的原料制成:干姜5~15份,茯苓5~15份,陈皮5~15份,藿香3~7份,艾叶3~7份。该中药组合物具有组方简单、药材来源广泛、成本低的优势,便于制药企业进行药品生产、质量控制和推广应用。经过临床试验证明,本发明产品治疗猪流行性腹泻的总有效率为91.30%,总治愈率为86.78%。在猪场发生猪流行性腹泻疫情时,使用本发明的产品,可以迅速减少母猪、公猪、仔猪、育肥猪群中的发病和流行,从而缩短疫情流行时间,减少猪场损失。
Description
技术领域
本发明涉及兽药技术领域,具体涉及一种治疗猪流行性腹泻的中药组合物。
背景技术
自2010年以来,每年冬季在我国发生的猪流行性腹泻给养猪业造成了巨大的损失。发生疫情的猪场,哺乳仔猪死亡率多在50%以上,个别猪场达到100%;同时疫情在保育、育肥、种猪群中也有广泛流行,猪场生产、经营受到严重扰乱。调查表明,引起猪场冬季腹泻的主要病原体为猪流行性腹泻病毒(Porcine Epidemic Diarrhea Virus, PEDV);同时有的病例也检测到猪传染性胃肠炎、猪轮状病毒、猪大肠杆菌等多种病原。
各种年龄的猪都能感染发病。日龄越小,发病、死亡越严重。哺乳仔猪、保育猪、肥育猪的发病率很高,尤以哺乳仔猪受害最为严重;母猪发病率变动很大,约为15%~90%。病猪是主要传染源。PEDV存在于肠绒毛上皮细胞和肠系膜淋巴结,随粪便排出后,污染环境、饲料、饮水、交通工具及用具等而传染。主要感染途径是消化道。如果一个猪场陆续有仔猪出生或断奶,PEDV会不断感染失去母源抗体的断奶仔猪,使本病呈地方流行性。在这种繁殖场内,猪流行性腹泻可造成5~8周龄保育仔猪的顽固性腹泻。
PEDV经口和鼻感染后,进入小肠,在小肠和结肠绒毛上皮细胞浆中进行复制。由于病毒增殖造成细胞器的损伤,继而出现细胞形态、结构及功能障碍。肠绒毛萎缩,吸收表面积减少,营养物质和水分吸收障碍,这是引起腹泻的主要原因。严重腹泻引起脱水、电解质平衡紊乱,是导致病猪死亡的主要原因。
自然感染PEDV的潜伏期为5~8天。主要的临床症状为水样腹泻,或者在腹泻之间有呕吐。呕吐多发生于吃食或吃奶后。症状的轻重随年龄的大小而有差异,年龄越小,症状越重。一周龄内仔猪发生腹泻后3~4天,呈现严重脱水而死亡,死亡率约50%,最高可达100%。保育、育肥、种猪的病猪体温正常或偏低,精神沉郁,食欲减退或废绝;腹泻持续约7天,逐渐恢复正常。少数猪恢复后生长发育不良。有的种猪症状较轻,仅表现呕吐,排出稀软粪便,3~4天可自愈。哺乳母猪可见腹泻、腹痛,伏卧不愿哺乳仔猪,3~5天后乳汁很少或者无乳,仔猪即使不再腹泻也因为母猪无乳而饿死。
具有特征性的病理变化主要见于仔猪的小肠。小肠肠管扩张,内容物稀薄,呈黄色、泡沫状,肠壁弛缓,缺乏弹性,变薄有透明感,肠黏膜绒毛严重萎缩。部分病例胃底黏膜潮红充血,并有粘液覆盖,胃内容物呈鲜黄色并混有大量乳白色凝乳块。组织学变化,见空肠段上皮细胞的空泡形成、上皮细胞核浓缩、胞浆嗜酸性变化和表皮脱落,肠绒毛显著萎缩。绒毛长度与肠腺隐窝深度的比值由正常的7︰1降到3︰1。上皮细胞脱落最早发生于腹泻后2小时。
猪流行性腹泻应用抗生素治疗无效。由于PEDV基因变异,目前的野毒流行株与疫苗毒株(CV777)的主要抗原分子结构存在差异,以及PEDV对细胞的适应性较低、分离培养困难,目前市场上没有较好的疫苗能够预防本病。
在发病的猪场,较多采用发病仔猪的粪便和小肠内容物作为接种材料对分娩前2周的怀孕母猪进行人工感染,期望母猪感染后获得抗体,进而对仔猪形成保护力。此种方法受到接种材料来源的限制,接种材料中的病毒含量不可控、预防效果不稳定,并存在扩散病原、增加病原体在猪场流行的风险。尤其是在猪场蓝耳病流行比较严重的背景下,此种方法的安全性、有效性都是大打折扣。因此,寻求有效、安全的中药制剂进行预防与治疗本病,具有巨大的经济效益和社会效益。
现公开的有关治疗猪流行性腹泻的中药组合物其中药味数多,个别药材稀缺,成本高昂,疗效一般,不利于制药企业进行药品生产、质量控制和推广应用。
发明内容
鉴于上述不足之处,本发明的目的在于提供一种中药味数少,疗效佳,药材来源广泛,成本低廉,更加有利于制药企业进行药品生产、质量控制和推广应用的治疗猪流行性腹泻的中药组合物。
为了达到上述目的,本发明采用了以下技术方案:
一种治疗猪流行性腹泻的中药组合物,由以重量份配比的原料制成:干姜5~15份,茯苓5~15份,陈皮5~15份,藿香3~7份,艾叶3~7份。
进一步的,该中药组合物由以重量份配比的原料制成:干姜10份,茯苓10份,陈皮10份,藿香5份,艾叶5份。
所述的中药组合物可以制备成临床上动物可接受的口服制剂。
所述的中药组合物可以制备成临床上动物可接受的散剂、口服液剂、酊剂、浸膏、流浸膏剂。
一种治疗猪流行性腹泻的中药组合物的制备方法,包括以下步骤:
1)按照配方量称取各药物原料;
2)将步骤1)称取的各药物原料粉碎,过80~200目筛,混合均匀,分装,即得散剂。
又或,一种治疗猪流行性腹泻的中药组合物的制备方法,包括以下步骤:
1)按照配方量称取干姜、陈皮、藿香、艾叶,粉碎,过24目筛,加入12倍量的水浸泡1h,水蒸气蒸馏法提取挥发油8 h,收集蒸馏液,备用;蒸馏后的水溶液滤过,得滤液备用;
2)按照配方量称取茯苓,加入10倍量的水,浸泡1 h,煎煮1.5 h,滤过,收集煎煮液;滤渣中再加入8倍量的水,煎煮1 h,滤过,合并煎煮液;
3)把蒸馏后的滤液和步骤2)所得煎煮液混合,减压浓缩至生药量与药液量之比为1.2∶1,收集浓缩液;
4)浓缩液中加入浓度为95%的乙醇得混合液,并且使95%乙醇在混合液中质量含量为65%~70%,然后冷藏静置48 h,滤过,滤液回收乙醇至无醇味,然后加入步骤1)所得蒸馏液,与药学上可接受的载体制备成口服液剂,且口服液剂中含生药量为1g/ ml。
又或,一种治疗猪流行性腹泻的中药组合物的制备方法,包括以下步骤:
1)按照配方量称取干姜、陈皮、茯苓、藿香、艾叶,加入12倍量的水,浸泡1 h,水蒸气蒸馏法提取挥发油8 h,收集蒸馏液,备用;蒸馏后的水溶液滤过,得滤液备用;
2)把滤液减压浓缩至生药量与药液量之比为1∶1,收集浓缩液;
3)浓缩液中加入浓度为95%的乙醇得混合液,并且使95%乙醇在混合液中质量含量为65%~70%,然后冷藏静置48 h,滤过,滤液回收乙醇至无醇味,然后加入步骤1)所得蒸馏液,与药学上可接受的载体制备成口服液剂,且口服液剂中含生药量为1g/ ml。
本发明的中药组合物的在治疗猪流行性腹泻中的应用。1~7日龄仔猪口服1 ml口服液剂,8~20日龄仔猪口服2 ml口服液剂,一日2次,连用2~3 d。20日龄以上的保育仔猪、育肥猪、母猪、公猪每kg饲料中添加散剂10 g,连续2~3 d;或者每kg饮水中添加口服液剂1ml,连续2~3 d。
本发明根据中兽医学理论以及中兽医学对猪流行性腹泻的辨证:猪外感寒邪、过饮寒凉及久卧湿地,致寒邪直中脏腑,寒湿困脾,进而脾失健运,不能运化水谷和水湿,表现食欲不振和水样腹泻;寒为阴邪,易伤阳气,湿阻经脉,寒湿二邪共致气血运行不畅,经脉不通,阳气不宣,故而体温不高甚至形寒肢冷、腹痛;寒邪伤胃,致胃失和降、胃气上逆,则多发呕吐。母病及子,母体既受寒湿,致子体脾阳更虚,因而见仔猪出生不久即有发病,病情比母猪严重;又借助如“脾主运化”、“诸湿肿满,皆属于脾”、“冬季多寒病”、“寒邪直中脏腑,最常损伤胃脾”、“胃气上逆,则见呕吐”、“湿郁气机,易损脾阳”、“脾喜燥恶湿,易受湿困”等病因病理观点。同时在对猪流行性腹泻病证特点(冬季发病较多,仔猪比母猪的病情严重,体温不高、食欲不振、腹痛、水样腹泻和呕吐。)和中药药理研究的基础上,通过中药防治猪流行性腹泻的原则:温中散寒、温经通脉、祛湿、止泻止呕,筛选出由五味中药制成的治疗猪流行性腹泻的中药组合物:
于姜,具有温中逐寒,回阳通脉,燥湿消痰的功效。
茯苓,具有渗湿利水,健脾宁心的功效。
陈皮,具有理气健脾、燥湿化痰的功效。
藿香,具有芳香化湿、和中止呕、宣散表邪、行气化滞的功效。
艾叶,具有温经止血,散寒止痛的功效。
上述五味中药中,干姜温中散寒、止泻止呕为主药;茯苓健脾利湿、引湿从小便出,陈皮健脾理气、止呕,共为辅药;藿香化湿和胃、引寒从表解,艾叶温经散寒止痛,共为佐使药。诸药配合,则具有温中散寒、温经止痛、祛湿、止泻止呕的功效。根据现代医学对中药药理的研究,该组合物具有抗细菌、抗病毒、抗炎症、修复消化道黏膜损伤、止泻止呕吐等作用,从而能够治疗猪流行性腹泻。
该中药组合物具有组方简单、药材来源广泛、成本低的优势,便于制药企业进行药品生产、质量控制和推广应用。经过临床试验证明,本发明产品治疗猪流行性腹泻的总有效率为91.30%,总治愈率为86.78%。在猪场发生猪流行性腹泻疫情时,使用本发明的产品,可以迅速减少母猪、公猪、仔猪、育肥猪群中的发病和流行,从而缩短疫情流行时间,减少猪场损失。
具体实施方式
通过下列实施例将更具体说明本发明的实施方式,但是应理解所述实施例仅是范例性的,不对本发明的范围构成任何限制。本领域技术人员应该理解的是,在不偏离本发明的精神和范围下可以对本发明技术方案的细节和形式进行修改或替换,但这些修改或替换均落入本发明的保护范围。
实施例1
一种治疗猪流行性腹泻的中药组合物散剂,取干姜50 g,茯苓50 g,陈皮50 g,藿香30 g,艾叶30 g,粉碎,过100目筛,混合均匀,即得。本产品在每kg猪饲料中的添加量为8~12 g。
实施例2
一种治疗猪流行性腹泻的中药组合物散剂,取干姜150 g,茯苓150 g,陈皮150 g,藿香70 g,艾叶70 g,粉碎,过100目筛,混匀,即得。本产品在每kg猪饲料中的添加量为8~12g。
实施例3
一种治疗猪流行性腹泻的中药组合物散剂,取干姜150 g,茯苓150 g,陈皮150 g,藿香30 g,艾叶30 g,粉碎,过100目筛,混匀,即得。本产品在每kg猪饲料中的添加量为8~12g。
实施例4
一种治疗猪流行性腹泻的中药组合物散剂,取干姜100 g,茯苓100 g,陈皮100 g,藿香50 g,艾叶50 g,粉碎,过100目筛,混合均匀,即得。本产品在每kg猪饲料中的添加量为8~12 g。
实施例5
一种治疗猪流行性腹泻的中药组合物散剂,取干姜100 g,茯苓100 g,陈皮100 g,藿香50 g,艾叶50 g,粉碎,过100目筛,混合均匀,即得。本产品在每kg猪饲料中的添加量为10 g。
实施例6
一种治疗猪流行性腹泻的中药组合物口服液剂,制备步骤如下:
1)取干姜100 g,陈皮100 g,藿香50 g,艾叶50 g,粉碎过24目筛,加入12倍量的水浸泡1 h,水蒸气蒸馏法提取挥发油8 h,收集蒸馏液,备用;蒸馏后的水溶液滤过,得滤液备用;
2)取茯苓100 g,加入10倍量的水,浸泡1 h,煎煮1.5 h,滤过,收集煎煮液;滤渣中再加入8倍量的水,煎煮1 h,滤过,合并煎煮液;
3)把蒸馏后的滤液和步骤2)所得煎煮液混合,减压浓缩至生药量与药液量之比为1.2∶1,收集浓缩液;
4)浓缩液中加入95%乙醇,得混合液,并且使95%乙醇在混合液中质量含量为70%,然后冷藏静置48 h,滤过,滤液回收乙醇至无醇味,然后加入步骤1)所得蒸馏液,与药学上可接受的载体制备成口服液剂,最终制得口服液剂400ml,口服液剂中含生药量为1g/ ml。
实施例7
一种治疗猪流行性腹泻的中药组合物口服液剂,制备步骤如下:
1)取干姜100 g,陈皮100 g,茯苓100 g,藿香50 g,艾叶50 g,加水4 800 g,浸泡1h,水蒸气蒸馏法提取挥发油8 h,收集蒸馏液,备用;蒸馏后的水溶液滤过,得滤液备用;
2)把滤液减压浓缩至400ml,收集浓缩液;
3)浓缩液中加入浓度为95%的乙醇得混合液,并且使95%乙醇在混合液中质量含量为65%,然后冷藏静置48 h,滤过,滤液回收乙醇至无醇味,然后加入步骤1)所得蒸馏液,与药学上可接受的载体制备成口服液剂,且口服液剂中含生药量为1g/ ml。
治疗试验例
试验动物:来自四川省广安市、双流县等地猪场的腹泻病例,临床和病理解剖诊断符合猪流行性腹泻的病证特征,排除猪瘟、猪伪狂犬病。
方法:母猪、保育猪病例,每kg饲料中添加实施例4的散剂产品10 g,连续3日;1~7日龄哺乳仔猪口服实施例6的口服液剂1 ml/头,8~20日龄哺乳仔猪口服实施例6的口服液剂2 ml/头,每日2次,连续3日。
疗效判定:用药2~3日粪便成形,色泽正常为治愈;腹泻症状明显减轻者为有效;未减轻或加重者为无效。
试验结果见下表
。
从上表可以看出,本发明产品治疗猪流行性腹泻的总有效率为91.30%,总治愈率为86.78%。
同样的,对实施例1、2、3、5所得的散剂也做了相应的功效评价试验,试验结果与实施例4散剂的功效评价试验结果无明显差别;对实施例7所得口服液剂也做了相应的功效评价试验,试验结果与实施例6口服液剂的功效评价试验结果无明显差别;故在此不作敷述。
Claims (4)
1.一种治疗猪流行性腹泻的中药组合物的制备方法,其特征在于,该制备方法包括以下步骤:
1)按重量份配比计,取干姜5~15份,茯苓5~15份,陈皮5~15份,藿香3~7份,艾叶3~7份,备用;
2)将步骤1)称取的各药物原料粉碎,过80~200目筛,混合均匀,分装,即得散剂。
2.一种治疗猪流行性腹泻的中药组合物的制备方法,其特征在于,该制备方法包括以下步骤:
1)按重量份配比计,称取干姜5~15份、陈皮5~15份、藿香3~7份、艾叶3~7份,粉碎,过24目筛,加入12倍量的水浸泡1 h,水蒸气蒸馏法提取挥发油8 h,收集蒸馏液,备用;蒸馏后的水溶液滤过,得滤液备用;
2)按重量份配比计,称取茯苓5~15份,加入10倍量的水,浸泡1 h,煎煮1.5 h,滤过,收集煎煮液;滤渣中再加入8倍量的水,煎煮1 h,滤过,合并煎煮液;
3)把蒸馏后的滤液和步骤2)所得煎煮液混合,减压浓缩至生药量与药液量之比为1.2∶1,收集浓缩液;
4)浓缩液中加入浓度为95%的乙醇得混合液,并且使95%乙醇在混合液中质量含量为65%~70%,然后冷藏静置48 h,滤过,滤液回收乙醇至无醇味,然后加入步骤1)所得蒸馏液,与药学上可接受的载体制备成口服液剂,且口服液剂中含生药量为1g/ ml。
3.一种治疗猪流行性腹泻的中药组合物的制备方法,其特征在于,该制备方法包括以下步骤:
1)按重量份配比计,称取干姜5~15份,陈皮5~15份,茯苓5~15份,藿香3~7份,艾叶3~7份,加入12倍量的水,浸泡1 h,水蒸气蒸馏法提取挥发油8 h,收集蒸馏液,备用;蒸馏后的水溶液滤过,得滤液备用;
2)把滤液减压浓缩至生药量与药液量之比为1∶1,收集浓缩液;
3)浓缩液中加入浓度为95%的乙醇得混合液,并且使95%乙醇在混合液中质量含量为65%~70%,然后冷藏静置48 h,滤过,滤液回收乙醇至无醇味,然后加入步骤1)所得蒸馏液,与药学上可接受的载体制备成口服液剂,且口服液剂中含生药量为1g/ ml。
4.一种如权利要求1-3任意一项所述治疗猪流行性腹泻的中药组合物的制备方法,其特征在于,按重量份配比计,所述干姜10份,茯苓10份,陈皮10份,藿香5份,艾叶5份。
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