CN104435966A - Compound fermented Chinese medicine for promoting livestock estrus and preparation method of compound fermented Chinese medicine - Google Patents

Compound fermented Chinese medicine for promoting livestock estrus and preparation method of compound fermented Chinese medicine Download PDF

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CN104435966A
CN104435966A CN201410828433.6A CN201410828433A CN104435966A CN 104435966 A CN104435966 A CN 104435966A CN 201410828433 A CN201410828433 A CN 201410828433A CN 104435966 A CN104435966 A CN 104435966A
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parts
chinese medicine
fructus
compound
radix
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郝伟
杨荣恩
唐光武
申法刚
王世山
武全梅
周志领
崔威力
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HENAN BAOSHU BIOTECHNOLOGY Co Ltd
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HENAN BAOSHU BIOTECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/746—Morinda
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract

The invention discloses a compound fermented Chinese medicine for promoting livestock estrus. The compound fermented Chinese medicine is prepared from raw materials including, by weight, 20-60 parts of morinda root, 10-50 parts of fructus cnidii, 10-40 parts of fennel, 2-10 parts of actinolite, 10-40 parts of epimedium, 5-20 parts of angelica, 5-20 parts of wolfberry fruits, 5-25 parts of plantain seeds, 20-60 parts of root-bark of tree peony, 5-20 parts of sophorae, 5-15 parts of sharpleaf galangal fruits, 10-50 parts of frost mulberry leaves and 10-50 parts of motherwort. Traditional Chinese medicine formulae are combined with modern microorganism technology, crushed by ultrasonic waves, added with a fermentation medium and compound bacteria strain culture solution with a certain proportion and then fermented, stabilizers are added into mature solid yeast, and vacuum low-temperature drying is performed to prepare the compound fermented Chinese medicine. By the aid of a Chinese medicine biological agent prepared after microorganism fermentation and metabolism, absorption and utilization of the medicine can be remarkably improved, livestock body immunity functions are improved, a urogenital system is restored, productivity of livestock is improved, and immunosuppressive diseases and the like are effectively prevented and treated.

Description

A kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry and preparation method thereof
Technical field
The invention belongs to herbal medicine technical field, be specifically related to a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry and preparation method thereof.
Background technology
Poultry are in feeding and management process, due to factors such as feeding and management factor, environment, weathers, the physiology causing being caused by nutritional imbalance, some nutrient deficiency and deficiency, pathological factor etc., pathological change, thus cause delay of oestrusing, oestrus not obvious, non-estrus, Repeat breeding etc.
Herbal medicine is resist exopathogenic factor invade the QI and blood caused change by cultivating vigour in body substantially, fundamentally can improve body constitution and promote the growth of rehabilitation and histoorgan.And modern age, doctor trained in Western medicine advocated solution disease for first, alleviated apparent.Positive so-called Western medicine bactericidal antiphlogistic is controlled " mark ", Chinese medicine enhancing body anti pathologic immunity function, is positive controlling " basis ".Chinese medicine is natural green medicine, not easily causes receptor drug resistance and sequela, noresidue, ensures food safety.Improve absorbing of its effective ingredient by the fermentation of microbial ecological agent simultaneously.
Veterinary often uses Chinese powder medicine and oral liquid etc., and compound fermentation Chinese medicine is a kind of novel special dosage form on veterinary drug.Modern herbal medicine theory is pointed out, a herb has nearly more than 300 plants active ingredient, usually can not play its due effect completely, can only do some make up by escalated dose, cause and utilize herbal medicine disease therapy high cost.The physiological characteristics of birds is that intestinal is short and small in addition, and content excreted at 3-4 hour, and make absorption not thorough, trap only has about 30%.
Summary of the invention
The technical problem to be solved in the present invention is that effective ingredient in common Chinese powder medicine of promoting the sexual maturity for poultry and oral liquid is because absorb not thorough, and its due effect can not be played completely, for solving the problem, the invention provides a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry and preparation method thereof.
The object of the invention is to realize in the following manner:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, be made up of the crude drug of following weight portion: Radix Morindae Officinalis 20-60 part, Fructus Cnidii 10-50 part, Fructus Foeniculi 10-40 part, Actinolitum 2-10 part, Herba Epimedii 10-40 part, Radix Angelicae Sinensis 5-20 part, Fructus Lycii 5-20 part, Semen Plantaginis 5-25 part, Cortex Moutan 20-60 part, Radix Sophorae Flavescentis 5-20 part, Fructus Alpiniae Oxyphyllae 5-15 part, Folium Mori 10-50 part, Herba Leonuri 10-50 part.
Be made up of the crude drug of following weight portion: Radix Morindae Officinalis 30-50 part, Fructus Cnidii 20-40 part, Fructus Foeniculi 10-30 part, Actinolitum 2-6 part, Herba Epimedii 15-30 part, Radix Angelicae Sinensis 5-15 part, Fructus Lycii 5-12 part, Semen Plantaginis 10-20 part, Cortex Moutan 30-50 part, Radix Sophorae Flavescentis 5-12 part, Fructus Alpiniae Oxyphyllae 5-12 part, Folium Mori 20-40 part, Herba Leonuri 20-40 part.
Be made up of the crude drug of following weight portion: Radix Morindae Officinalis 40 parts, Fructus Cnidii 30 parts, Fructus Foeniculi 20 parts, Actinolitum 5 parts, Herba Epimedii 20 parts, Radix Angelicae Sinensis 10 parts, Fructus Lycii 10 parts, Semen Plantaginis 15 parts, Cortex Moutan 40 parts, Radix Sophorae Flavescentis 10 parts, Fructus Alpiniae Oxyphyllae 10 parts, Folium Mori 30 parts, Herba Leonuri 30 parts.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 32-42 DEG C of bottom fermentation 15 ~ 20 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
Described composite bacteria liquid is 1-5 part, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10 8cFU/mL to 1.0 × 10 8during CFU/mL only;
B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 1:(0.3 ~ 0.6): (0.4 ~ 0.7): (0.4 ~ 0.7) ratio is mixed to get composite bacteria liquid.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.03 ~ 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.007 ~ 0.010% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 0 ~ 4 DEG C, drying time 12 ~ 15h.
The effect of each raw material of the present invention:
Radix Morindae Officinalis: sweet in the mouth, pungent, slightly warm in nature.Energy kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Cure mainly impotence due to deficiency of the kidney, infertile; Rheumatic arthralgia, soreness of the waist and knees, walks with difficulty.
Fructus Cnidii: bitter in the mouth is flat.Xin Gan is nontoxic.Slightly poisonous.Mildly bitter flavor gas is pungent, warm in nature.Warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis.
Fructus Foeniculi: warm in nature, acrid in the mouth.Return liver,kidney,spleen, stomach warp.Stimulating appetite, cold expelling of regulating the flow of vital energy, has supporing yang road.Cure mainly: cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain; Hernia pain, painful and swollen testis; Stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain.
Actinolitum: sweet, temperature.Gui Jing: enter kidney channel.Function: warming the kidney to invigorate YANG.Cure mainly: part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness, sexual impotence, seminal emission premature ejaculation, cold uterus is infertile, soreness of the waist and knees, the diseases such as metrorrhagia.
Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth is pungent.GUIXIN, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Fructus Lycii: the flat effect with the liver and the kidney tonifying of sweet in the mouth, property, is improved the effect of immunity of organisms, can QI invigorating strong essence, nourishing the liver and kidney, defying age, only quench one's thirst, warm up health, antineoplastic effect.
Semen Plantaginis: sweet, is slightly cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Cortex Moutan: bitter in the mouth is pungent is nontoxic.Enter the heart, liver, kidney channel.Have and purify the blood, the function of promoting blood circulation to remove blood stasis.Cure mainly macule to spit blood, amenorrhea due to stagnation of blood, premenstrual gesture, carbuncle sore tumefacting virus, traumatic blood stasis, the deficiency of YIN sends out gesture, lossless hectic fever due to YIN-deficiency.
Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Fructus Alpiniae Oxyphyllae: pungent, temperature, returns kidney, spleen channel.Warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Cure mainly cold air stomachache, invasion by pathogenic cold is vomited and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine etc.
Folium Mori: sweetness and bitterness is trembled with fear, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
In formula of the present invention, Radix Morindae Officinalis, Fructus Cnidii, Herba Epimedii are monarch drug, and the pungent tepor of Radix Morindae Officinalis sweet in the mouth, returns kidney, Liver Channel, kidney-replenishing, bone and muscle strengthening, expelling wind and removing dampness, the arduous temperature of Fructus Cnidii, warming the kidney to invigorate YANG, dispeiling pathogenic wind and removing dampness, parasite killing, Herba Epimedii Gan Xinwen, return Liver and kidney warp, kidney-replenishing, bone and muscle strengthening, expelling wind and removing dampness, three taste mutual reinforcements between are use, Synergistic; Actinolitum, Radix Angelicae Sinensis, Fructus Lycii, Cortex Moutan are ministerial drug, and the salty temperature of Actinolitum, returns kidney channel, warming the kidney to invigorate YANG, and can carry his medicine and enter kidney, Radix Angelicae Sinensis Gan Xinwen, return liver, the heart, spleen channel, blood-supplementing blood-nourishing, promoting blood flow to regulate menstruation pain relieving, moisturizes laxation; Fructus Lycii is sweet flat, and return liver, kidney channel, liver and kidney tonifying, replenishing vital essence to improve eyesight, Cortex Moutan toil is slightly cold, GUIXIN; Liver; Kidney; Lung meridian, blood circulation promoting and blood stasis dispelling, clearing away heat and cooling blood; Three tastes share, warming the kidney to invigorate YANG liver and kidney tonifying; Fructus Foeniculi, Fructus Alpiniae Oxyphyllae are adjuvant drug, pungent tepor, Fructus Foeniculi warming the spleen warming the kidney, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach; Fructus Alpiniae Oxyphyllae enters the heart, spleen; Kidney channel, the kidney warming controlling nocturnal emission with astringent drugs reducing urination, saliva is taken the photograph in warming the spleen appetizing; Semen Plantaginis is sweet to be slightly cold, and enters kidney, bladder, liver, lung meridian, function relieving stranguria by diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat-phlegm, Radix Sophorae Flavescentis bitter cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel, heat clearing and damp drying, parasite killing, diuresis; Folium Mori sweetness and bitterness is trembled with fear, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight; Herba Leonuri toil is slightly cold, heat clearing and damp drying, dispelling wind and heat pathogens, promoting blood circulation to restore menstrual flow, and diuresis goes to amass, coordinating the actions of various ingredients in a prescription, altogether for making medicine.Therefore, full side demonstrate and can effectively treat non-estrus, effect that is not obvious, Repeat breeding of oestrusing.Invention enhances the function that poultry are promoted the sexual maturity, effectively can treat non-estrus that poultry a variety of causes causes or the disease such as not obvious of oestrusing, alleviate the potential safety hazard that chemical medicine causes, add the safety of medication.
Positive beneficial effect of the present invention:
(1) from traditional Chinese veterinary medicine angle analysis, " exogenous pathogen mutual aid " is numerous disease predisposing factors, and when the five internal organs that namely traditional Chinese medical science is said are in " void ", virus is taken advantage of a weak point, and causes pathogen being excessive but vital QI weak, disease-resistant unable; Many because of the damp and hot fire-transformation of diseases caused by exogenous pathogenic factor, cause inhibited pulmonary QI, abnormal ascending-descending of QI, imbalance of YIN and YANG.Chinese herbal medicine can YIN and YANG balance regulating, treating both the principal and secondary aspects of a disease, make body constitutionally, immunity is thought and acted in one and the same way, equilibrium between yin and yang, thus reach the ideal cultivation state of " ill to send out less, morbidity die less ".The present invention's science of being carried out by various Chinese medicine reasonable compatibility is extracted and is used, play the complementary action of different mechanism of action, thus the effect playing stronger antibacterial, antiviral, raising immunity, promote the sexual maturity, the effectively non-estrus that causes for the treatment of poultry a variety of causes or the disease such as not obvious of oestrusing.
(2) safety of the present invention is high, and through acute oral toxicity test, local excitation test and pyrogenic test, animal subject is in a good state of health, and does not all occur untoward reaction.
(3) the present invention has warming the kidney to invigorate YANG, dispeiling pathogenic wind and removing dampness, blood-supplementing blood-nourishing, promoting blood flow to regulate menstruation analgesic effect, enhances the function that poultry are promoted the sexual maturity, and effectively can treat non-estrus that poultry a variety of causes causes or the disease such as not obvious of oestrusing.
The present invention adopts controlled release and targeting technology, makes medicine directly can arrive target position, and extends effective time, transformed simultaneously by micro-ecology fermentation, enhance the curative effect of Chinese herbal medicine, improve the microecological balance of body; Adopt microbial fermentation technology, the effective ingredient of medicine is converted into and is easy to absorb and fast onset effect, adopt ultrasonic grinding technology simultaneously, effective ingredient is not destroyed, ensure that effective ingredient is sufficient, drug effect increases; Ensure the core technology of product, ensure quality and the curative effect of product; Adopt advanced finger print identification technology, ensure that the quality of selected Chinese crude drug is excellent level.
Advantage of the present invention is specific as follows:
1, drug effect plays rapidly, and side effect is little, and treatment time is short, easy to use.
This Chinese herbal medicine through ultrasonic grinding and cell wall wall breaking technology, then carries out micro-ecology fermentation, and direct spice uses.Prove according to the clinical trial of 100 non-estrus sows, haul oneself willingly into observation post administration, feed intake improves, and within 12 ~ 14 days, starts to oestrus obviously, obtains promising result after breeding.
2, drug absorption is abundant, and the persistent period that plays a role is long, lasting medicine.
Through comparing: normal Chinese herbal medicine stops 2-6 hour at digestive system, and after microbial fermentation technology process, be 8-12 hour in the effective time of birds digestive system, substantially prolongs the time of staying in intestinal, absorption rate significantly increases, and through comparing, common Chinese (40-60 order) can detect a large amount of Chinese medicine prototypes after discharging with feces in intestinal, and Composite fermentation type Chinese medicine prepared by the present invention is after discharging through feces, almost can't check.MIC also obviously differs simultaneously, and Composite fermentation type Chinese medicine prepared by the present invention is higher than common Chinese by 95%.
3, body non-specific immunity strengthens, and body weight obviously increases, and feed conversion rate improves, and premunition strengthens, and protective rate improves.
Chinese medicine prescription combines with Modern microbiological technology and prepares a kind of traditional Chinese biological preparation by the present invention, said preparation is with Morinda officinalis How, Fructus Cnidii, Fructus Foeniculi, Actinolitum, Herba Epimedii, Radix Angelicae Sinensis, Fructus Lycii, Semen Plantaginis, Cortex Moutan, Radix Sophorae Flavescentis, Fructus Alpiniae Oxyphyllae, Folium Mori, Herba Leonuris etc. are raw material, wheat bran is added after ultrasonic grinding, bean cake, ammonium sulfate, magnesium sulfate, manganese sulfate, calcium carbonate and suitable quantity of water composition fermentation medium, add a certain proportion of compound bacteria bacteria culture fluid, ferment, ripe solid fermentation thing adds stabilizing agent, carry out vacuum dehydrating at lower temperature to be prepared from.Traditional Chinese biological preparation prepared after fermentable metabolism, can significantly improve absorbing of medicine, improves poultry body's immunity, repairs genitourinary system, improves the fertility performance of poultry, effectively control immunosuppressive disease etc.
Common Chinese was just excreted by poultry at 3-4 hour, and make absorption thorough, trap only has about 30%, and fermented type Chinese medicine is almost all absorbed in section at this moment.Compound fermentation Chinese medicinal ointment be Chinese herbal medicine through ultrasonic grinding, then add compound bacteria-fermented and form, the efficient composition such as albumen, tannin, starch in not removed Chinese herbal medicine, and these compositions play vital effect in treatment of diseases.Be converted into the composition that body is convenient to absorb simultaneously with microbial action, accelerate health care and treatment speed, improve health-care effect and curative effect, improve the microecological environment of body, improve animal spontaneous recovery and resistance against diseases, improve animal feed rate of returns.As can be seen here, compound fermentation Chinese medicine is greatly be better than other form of Chinese drug on pharmacological effect.
Detailed description of the invention
Following composite bacteria liquid self-control or commercially available, described various increasing bacterial context soup is commercially available, and addition performs according to national standard.
Embodiment 1:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, be made up of the crude drug of following weight portion: Radix Morindae Officinalis 20-60 part, Fructus Cnidii 10-50 part, Fructus Foeniculi 10-40 part, Actinolitum 2-10 part, Herba Epimedii 10-40 part, Radix Angelicae Sinensis 5-20 part, Fructus Lycii 5-20 part, Semen Plantaginis 5-25 part, Cortex Moutan 20-60 part, Radix Sophorae Flavescentis 5-20 part, Fructus Alpiniae Oxyphyllae 5-15 part, Folium Mori 10-50 part, Herba Leonuri 10-50 part.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 32-42 DEG C of bottom fermentation 15 ~ 20 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
Described composite bacteria liquid is 1-5 part, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10 8cFU/mL to 1.0 × 10 8during CFU/mL only;
B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 1:(0.3 ~ 0.6): (0.4 ~ 0.7): (0.4 ~ 0.7) ratio is mixed to get composite bacteria liquid.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.03 ~ 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.007 ~ 0.010% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 0 ~ 4 DEG C, drying time 12 ~ 15h.
The usage of medicine and consumption: in feedstuff gross mass 0.5 ~ 1% ratio make an addition in feedstuff and throw something and feed.
Embodiment 2:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 200g, Fructus Cnidii 100g, Fructus Foeniculi 100g, Actinolitum 20g, Herba Epimedii 100g part, Radix Angelicae Sinensis 50g, Fructus Lycii 50g, Semen Plantaginis 50g, Cortex Moutan 200g, Radix Sophorae Flavescentis 50g, Fructus Alpiniae Oxyphyllae 50g, Folium Mori 100g, Herba Leonuri 100g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 32 DEG C of bottom fermentations 15 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20%, bean cake 3%, ammonium sulfate 1%, magnesium sulfate 0.5%, calcium carbonate 1% and water 20%.
Described composite bacteria liquid is 10g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10 8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.3:0.4:0.4 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.03% of step (3) tunning gross mass, and the addition of propyl gallate is 0.007% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 0 DEG C, drying time 12h.
Embodiment 3:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 250g, Fructus Cnidii 150g, Fructus Foeniculi 140g, Actinolitum 30g, Herba Epimedii 140g part, Radix Angelicae Sinensis 70g, Fructus Lycii 70g, Semen Plantaginis 80g, Cortex Moutan 250g, Radix Sophorae Flavescentis 70g, Fructus Alpiniae Oxyphyllae 60g, Folium Mori 150g, Herba Leonuri 150g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 35 DEG C of bottom fermentations 16 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 22%, bean cake 3.2%, ammonium sulfate 1.2%, magnesium sulfate 0.6%, calcium carbonate 1.2% and water 22%.
Described composite bacteria liquid is 20g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.6 × 10 8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.4:0.5:0.5 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.04% of step (3) tunning gross mass, and the addition of propyl gallate is 0.008% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 1 DEG C, drying time 13h.
Embodiment 4:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 300g, Fructus Cnidii 200g, Fructus Foeniculi 180g, Actinolitum 40g, Herba Epimedii 180g part, Radix Angelicae Sinensis 90g, Fructus Lycii 90g, Semen Plantaginis 110g, Cortex Moutan 300g, Radix Sophorae Flavescentis 90g, Fructus Alpiniae Oxyphyllae 70g, Folium Mori 200g, Herba Leonuri 200g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 38 DEG C of bottom fermentations 18 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 24%, bean cake 3.4%, ammonium sulfate 1.4%, magnesium sulfate 0.7%, calcium carbonate 1.4% and water 24%.
Described composite bacteria liquid is 30g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.8 × 10 8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.5:0.6:0.6 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.05% of step (3) tunning gross mass, and the addition of propyl gallate is 0.009% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 2 DEG C, drying time 14h.
Embodiment 5:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 350g, Fructus Cnidii 250g, Fructus Foeniculi 220g, Actinolitum 50g, Herba Epimedii 220g part, Radix Angelicae Sinensis 110g, Fructus Lycii 110g, Semen Plantaginis 130g, Cortex Moutan 350g, Radix Sophorae Flavescentis 110g, Fructus Alpiniae Oxyphyllae 80g, Folium Mori 250g, Herba Leonuri 250g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 42 DEG C of bottom fermentations 20 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 26%, bean cake 3.6%, ammonium sulfate 1.6%, magnesium sulfate 0.8%, calcium carbonate 1.6% and water 26%.
Described composite bacteria liquid is 40g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.9 × 10 8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.6:0.7:0.7 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.010% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 4 DEG C, drying time 15h.
Embodiment 6:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 400g, Fructus Cnidii 300g, Fructus Foeniculi 260g, Actinolitum 60g, Herba Epimedii 260g part, Radix Angelicae Sinensis 130g, Fructus Lycii 130g, Semen Plantaginis 150g, Cortex Moutan 400g, Radix Sophorae Flavescentis 130g, Fructus Alpiniae Oxyphyllae 90g, Folium Mori 300g, Herba Leonuri 300g.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 28%, bean cake 3.8%, ammonium sulfate 1.8%, magnesium sulfate 0.9%, calcium carbonate 1.8% and water 28%.
Described composite bacteria liquid is 50g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 1.0 × 10 8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.5:0.5:0.5 ratio.
The other the same as in Example 1.
Embodiment 7:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 450g, Fructus Cnidii 350g, Fructus Foeniculi 300g, Actinolitum 70g, Herba Epimedii 300g part, Radix Angelicae Sinensis 150g, Fructus Lycii 150g, Semen Plantaginis 180g, Cortex Moutan 450g, Radix Sophorae Flavescentis 150g, Fructus Alpiniae Oxyphyllae 100g, Folium Mori 350g, Herba Leonuri 350g.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 30%, bean cake 4%, ammonium sulfate 2%, magnesium sulfate 1%, calcium carbonate 2% and water 30%.
The other the same as in Example 1.
Embodiment 8:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 500g, Fructus Cnidii 400g, Fructus Foeniculi 340g, Actinolitum 80g, Herba Epimedii 340g part, Radix Angelicae Sinensis 170g, Fructus Lycii 170g, Semen Plantaginis 200g, Cortex Moutan 500g, Radix Sophorae Flavescentis 170g, Fructus Alpiniae Oxyphyllae 120g, Folium Mori 400g, Herba Leonuri 400g.
The other the same as in Example 1.
Embodiment 9:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 550g, Fructus Cnidii 450g, Fructus Foeniculi 370g, Actinolitum 90g, Herba Epimedii 370g part, Radix Angelicae Sinensis 190g, Fructus Lycii 190g, Semen Plantaginis 220g, Cortex Moutan 550g, Radix Sophorae Flavescentis 190g, Fructus Alpiniae Oxyphyllae 140g, Folium Mori 450g, Herba Leonuri 450g.
The other the same as in Example 1.
Embodiment 10:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 600g, Fructus Cnidii 500g, Fructus Foeniculi 400g, Actinolitum 100g, Herba Epimedii 400g part, Radix Angelicae Sinensis 200g, Fructus Lycii 200g, Semen Plantaginis 250g, Cortex Moutan 600g, Radix Sophorae Flavescentis 200g, Fructus Alpiniae Oxyphyllae 150g, Folium Mori 500g, Herba Leonuri 500g.
The other the same as in Example 1.
Embodiment 11:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 300g, Fructus Cnidii 200g, Fructus Foeniculi 100g, Actinolitum 20g, Herba Epimedii 150g, Radix Angelicae Sinensis 50g, Fructus Lycii 50g, Semen Plantaginis 100g, Cortex Moutan 300g, Radix Sophorae Flavescentis 50g, Fructus Alpiniae Oxyphyllae 50g, Folium Mori 200g, Herba Leonuri 200g.
The other the same as in Example 1.
Embodiment 12:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 500g, Fructus Cnidii 400g, Fructus Foeniculi 300g, Actinolitum 60g, Herba Epimedii 300g, Radix Angelicae Sinensis 150g, Fructus Lycii 120g, Semen Plantaginis 200g, Cortex Moutan 500g, Radix Sophorae Flavescentis 120g, Fructus Alpiniae Oxyphyllae 120g, Folium Mori 400g, Herba Leonuri 400g.
The other the same as in Example 1.
Embodiment 13:
For the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Radix Morindae Officinalis 400g, Fructus Cnidii 300g, Fructus Foeniculi 200g, Actinolitum 50g, Herba Epimedii 200g, Radix Angelicae Sinensis 100g, Fructus Lycii 100g, Semen Plantaginis 150g, Cortex Moutan 400g, Radix Sophorae Flavescentis 100g, Fructus Alpiniae Oxyphyllae 100g, Folium Mori 300g, Herba Leonuri 300g.
The other the same as in Example 1.
Clinical trial
About 30, Jiyuan, Henan pig farm sow non-estrus, compound fermentation Chinese medicine composition prepared by Application Example 13 carries out 0.5% feedstuff and adds use 15 days, and stepmother's pig feed intake of taking medicine significantly improves, rutting in 12 ~ 14 days.After breeding, 30 sows are all conceived, normal labor, and piglet is healthy and strong, lower 263 piglets of common property.And feed with the plain edition Chinese medicine of we, use 14 days, stepmother's pig feed intake of taking medicine significantly improves, rutting in 28 ~ 35 days.After breeding, 26 sows are all conceived, normal labor, and piglet is healthy and strong, lower 212 piglets of common property.
Above-described is only the preferred embodiment of the present invention, it should be pointed out that for a person skilled in the art, and not departing under general idea prerequisite of the present invention, can also make some changes and improvements, these also should be considered as protection scope of the present invention.

Claims (8)

1. for the compound fermentation type Chinese medicine that poultry are promoted the sexual maturity, it is characterized in that: be made up of the crude drug of following weight portion: Radix Morindae Officinalis 20-60 part, Fructus Cnidii 10-50 part, Fructus Foeniculi 10-40 part, Actinolitum 2-10 part, Herba Epimedii 10-40 part, Radix Angelicae Sinensis 5-20 part, Fructus Lycii 5-20 part, Semen Plantaginis 5-25 part, Cortex Moutan 20-60 part, Radix Sophorae Flavescentis 5-20 part, Fructus Alpiniae Oxyphyllae 5-15 part, Folium Mori 10-50 part, Herba Leonuri 10-50 part.
2. a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 1, is characterized in that: be made up of the crude drug of following weight portion: Radix Morindae Officinalis 30-50 part, Fructus Cnidii 20-40 part, Fructus Foeniculi 10-30 part, Actinolitum 2-6 part, Herba Epimedii 15-30 part, Radix Angelicae Sinensis 5-15 part, Fructus Lycii 5-12 part, Semen Plantaginis 10-20 part, Cortex Moutan 30-50 part, Radix Sophorae Flavescentis 5-12 part, Fructus Alpiniae Oxyphyllae 5-12 part, Folium Mori 20-40 part, Herba Leonuri 20-40 part.
3. a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 1, is characterized in that: be made up of the crude drug of following weight portion: Radix Morindae Officinalis 40 parts, Fructus Cnidii 30 parts, Fructus Foeniculi 20 parts, Actinolitum 5 parts, Herba Epimedii 20 parts, Radix Angelicae Sinensis 10 parts, Fructus Lycii 10 parts, Semen Plantaginis 15 parts, Cortex Moutan 40 parts, Radix Sophorae Flavescentis 10 parts, Fructus Alpiniae Oxyphyllae 10 parts, Folium Mori 30 parts, Herba Leonuri 30 parts.
4. the preparation method of a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 1, is characterized in that: concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 32-42 DEG C of bottom fermentation 15 ~ 20 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
5. the preparation method of a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 4, it is characterized in that: described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
6. the preparation method of a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 4, it is characterized in that: described composite bacteria liquid is 1-5 part, the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10 8cFU/mL to 1.0 × 10 8during CFU/mL only;
B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 1:(0.3 ~ 0.6): (0.4 ~ 0.7): (0.4 ~ 0.7) ratio is mixed to get composite bacteria liquid.
7. the preparation method of a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 4, it is characterized in that: described stabilizing agent is made up of sodium benzoate and propyl gallate, the addition of sodium benzoate is 0.03 ~ 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.007 ~ 0.010% of step (3) tunning gross mass.
8. the preparation method of a kind of compound fermentation type Chinese medicine of promoting the sexual maturity for poultry according to claim 4, is characterized in that: described vacuum dehydrating at lower temperature temperature is 0 ~ 4 DEG C, drying time 12 ~ 15h.
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CN106879859A (en) * 2016-12-30 2017-06-23 河南金尔康生物科技有限公司 A kind of beneficial mother promotes the sexual maturity and increases scattered feed addictive of egg and preparation method thereof, application
CN107373023A (en) * 2017-09-15 2017-11-24 河南科技大学 A kind of young quail fermented type Chinese herbal feed additive and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106879859A (en) * 2016-12-30 2017-06-23 河南金尔康生物科技有限公司 A kind of beneficial mother promotes the sexual maturity and increases scattered feed addictive of egg and preparation method thereof, application
CN107373023A (en) * 2017-09-15 2017-11-24 河南科技大学 A kind of young quail fermented type Chinese herbal feed additive and preparation method thereof

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