CN104435899A - Traditional Chinese medicine preparation for treating rheumatic joint pain and preparation - Google Patents

Traditional Chinese medicine preparation for treating rheumatic joint pain and preparation Download PDF

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CN104435899A
CN104435899A CN201510003549.0A CN201510003549A CN104435899A CN 104435899 A CN104435899 A CN 104435899A CN 201510003549 A CN201510003549 A CN 201510003549A CN 104435899 A CN104435899 A CN 104435899A
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herba
chinese medicine
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刘耿熙
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating rheumatic joint pain. The traditional Chinese medicine preparation for treating rheumatic joint pain mainly comprises, by weight, 10-20 parts of ligusticum wallichii, 12-25 parts of semen coicis, 9-15 parts of cirrhopetalum, 6-10 parts of rhizoma arisaematis (choleric temperament), 10-20 parts of teasel root, 15-25 parts of fructus arctii, 9-16 parts of melastoma dodecandrum, 9-12 parts of laciniate begonia herb, 8-15 parts of conic gymnadenia tuber, 15-20 parts of cassia twig, 8-12 parts of tongking pepper, 6-10 parts of chickweed and 15-20 parts of trichosanthes kirilowii. The traditional Chinese medicine preparation is prepared by traditional Chinese medicine materials and is safe and free of toxic and side effect. The traditional Chinese medicine preparation is studied and prepared according to the morbidity pathology of a patient suffering from the rheumatic joint pain with the traditional Chinese medicine medication principle, and the traditional Chinese medicine preparation has the effects of expelling wind and removing cold, invigorating the pulse-beat, invigorating qi and blood and the like and is stable in curative effect and capable of effectively relieving the pain of the patient.

Description

The Chinese medicine preparation for the treatment of rheumatic arthralgia and preparation
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and preparation for the treatment of rheumatic arthralgia.
Background technology
Arthralgia is the modal symptom of rheumatism, and rheumatic arthralgia is by the general name of the joint caused pain diseases of muscle and joint disease such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, hyperosteogeny, scapulohumeral periarthritis.Rheumatic arthritis belongs to allergic disease, mainly with febris acuta and arthralgia onset, typical performance is slight or moderate heating, migratory polyarthritis, affected joints mostly is knee joint, ankle, shoulder, elbow, the large joint such as wrist, is commonly transferred to another joint by a joint, and pathological changes local presents red, swollen, scorching hot, severe pain, some patients also has several joint to fall ill simultaneously, and atypical patient only has arthralgia and shows without other inflammation, and acute inflammation generally disappears in 2-4 week, do not stay sequela, but normal recurrent exerbation.Rheumatoid arthritis thinks human autoimmune's property disease more, also can be considered a kind of chronic syndrome, shows as the nonspecific inflammation in joint, periphery.Diseased joints and surrounding tissue thereof present Progressive symmetric erythrokeratodermia and destroy, and cause damaged joints generating function obstacle.The sickness rate women of rheumatoid arthritis is higher than male, and women is 2 ~ 3 times of male.Scapulohumeral periarthritis causes shoulder arthralgia and movable function obstacle due to shoulder joint surrounding soft tissue pathological changes.The common disease that scapulohumeral periarthritis is is cardinal symptom with shoulder arthralgia and inconvenient activity.This disease send out the age at about 50 years old well, women's sickness rate, a little more than male, is more common in physical labourer.Hyperosteogeny is cartilage, intervertebral disc owing to forming joint, soft tissue degeneration, the degenerations such as ligament, joint margins forms bony spur, and synovial membrane plumpness waits change, and occurs osteoclasia, cause insecondary hyperosteogeny, causing joint deformity, when being subject to abnormal load, causing arthralgia, a kind of disease of the symptoms such as limitation of activity, point constitutional and Secondary cases two kinds.Rheumatic arthralgia belongs to rheumatism involving the bone disease at traditional Chinese medical science category, pathogeny divide inside and outside two because of, endogenous cause of ill mainly contains innate deficiency, defends QI-insufficiency, or overworks, healthy energy damage, namely autoimmune function decline.Exopathogenic factor mainly contains the exopathogen such as wind, cold, wet, heat and invades human skin, meridians and bone network joint, fights in QI and blood, must not declare logical, multiple abscess joint, thus causes local qi depression to blood stasis and cause pain, and notably appearance activity is restricted, joint deformity.Western medicine adopts anti-inflammatory analgesic and immune suppressant drug for the treatment of rheumatic arthralgia more, and differential diagnosis in tcm treats, and adopts the therapeutic scheme of expelling wind and removing dampness, dredging collateral cold expelling more.Publication number CN 102309560 A(application number 201010213311.8) Chinese patent literature disclose a kind of Chinese medicine decoction for the treatment of rheumatic arthritis, mainly make for raw material to cross the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Asari, Rhizoma Chuanxiong, Ramulus Cinnamomi, Radix Clematidis, Herba speranskiae tuberculatae.Publication number CN 101982195 A(application number 201010522519.8) Chinese patent literature disclose a kind of medicine for the treatment of rheumatoid arthritis pain and preparation method thereof, raw material has ailanthus altissima (mill.) swingle branch, Ramulus Salicis Babylonicae, Ramulus Mori, Ramulus ulmi pumilae, Ramulus Persicae, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Radix Scrophulariae, the Radix Rehmanniae, Cortex Cinnamomi, Radix Et Rhizoma Rhei, Semen Momordicae, Olibanum, Myrrha, Resina Ferulae, Radix Glycyrrhizae, Rhizoma Curcumae Longae, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Radix Achyranthis Bidentatae, Cortex Acanthopancis, Radix Sanguisorbae, Oletum Trogopterori, Rhizoma Curcumae, Herba Asari, the Rhizoma Pinelliae, Fructus Xanthii, Radix Notoginseng, Herba Lycopodii, the Radix Astragali, Radix Saposhnikoviae, Plumbum preparatium.Publication number CN 102885961 A(application number 201110213012.9) Chinese patent literature disclose a kind of medicine and preparation method thereof for the treatment of rheumatic arthritis, rheumatoid arthritis, it is formed by Pharmaceutical formulations such as Formica fusca, Zaocys, Radix Aconiti Preparata, the Radix Rehmanniae, Tripterygium hypoglaucum, Radix Clematidis, Radix Cynanchi Paniculati, Caulis Spatholobi, Herba Epimedii, the Rhizoma Anemarrhenae, Cornu Cervi, Scorpio, Scolopendra Pheretima, Radix Notoginseng, the Radix Astragali, Fructus Chaenomelis, Herba Taxilli, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Rhizoma Chuanxiongs.
In a word, Chinese medicine has a lot of prescription in treatment rheumatic arthralgia, but these prescriptions lack clinical verification, and some compatibility unreasonable, therefore all needs to be further improved about the traditional Chinese medical science formula of rheumatic arthralgia and curative effect thereof and improves.
Summary of the invention
For the defect of prior art, the object of this invention is to provide a kind of Chinese medicine preparation and the preparation that can be made into the treatment rheumatic arthralgia that multi-pharmaceutics, preparation simply, easily take for a long time.
Technical scheme of the present invention is:
The Chinese medicine preparation for the treatment of rheumatic arthralgia, is prepared from primarily of following bulk drugs, is weight portion: Rhizoma Chuanxiong 10-20, Semen Coicis 12-25, Herba Cirrohopetali Andersonii 9-15, Rhizoma Arisaematis (bile system) 6-10, Radix Dipsaci 10-20, Fructus Arctii 15-25, Herba Melastomatis Dodecandri 9-16, Herba Begoniae Laciniatae 9-12, Rhizoma Gymnadeniae 8-15, Ramulus Cinnamomi 15-20, Herba Piperris Tonkinensis 8-12, Herba stellariae mediae 6-10, Fructus Trichosanthis 15-20.
In preferred scheme, Rhizoma Chuanxiong 12-18, Semen Coicis 16-21, Herba Cirrohopetali Andersonii 11-13, Rhizoma Arisaematis (bile system) 7-9, Radix Dipsaci 12-18, Fructus Arctii 17-23, Herba Melastomatis Dodecandri 10-15, Herba Begoniae Laciniatae 10-11, Rhizoma Gymnadeniae 10-13, Ramulus Cinnamomi 16-19, Herba Piperris Tonkinensis 9-11, Herba stellariae mediae 7-9, Fructus Trichosanthis 17-18.
Be more preferably, Rhizoma Chuanxiong 15, Semen Coicis 18.5, Herba Cirrohopetali Andersonii 12, Rhizoma Arisaematis (bile system) 8, Radix Dipsaci 15, Fructus Arctii 20, Herba Melastomatis Dodecandri 12.5, Herba Begoniae Laciniatae 10.5, Rhizoma Gymnadeniae 11.5, Ramulus Cinnamomi 17.5, Herba Piperris Tonkinensis 10, Herba stellariae mediae 8, Fructus Trichosanthis 17.5.
The preparation method of described decoction is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak and (preferably, soak 40-50 minute in 30-60 minute; Be more preferably, soak 45 minutes), heating is boiled, and turns little fire and decocts, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, and add step (3) gained clear paste, stirring and evenly mixing, heating is concentrated into 1/2nd of original volume, obtains decoction.
The preparation method of the Chinese medicine preparation decoction of described treatment rheumatic arthralgia, step (4) turn little fire decocts 30-50 minute, and (preferred, 35-45 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 40 minutes).
The preparation method of described powder is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merges twice filtrate, concentrating under reduced pressure, spraying dry;
(4) will remain other medical material decontaminations, cleaning, drying, made medical material pulverizes and sieves together with dry thing with step (1) (2) (3), obtains powder.
The preparation method of the Chinese medicine preparation powder of described treatment rheumatic arthralgia, step (4) was pulverized 100-140 mesh sieve and (preferably, was pulverized 110-130 mesh sieve; Be more preferably, pulverized 120 mesh sieves).
The preparation method of described pill is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merges twice filtrate, concentrating under reduced pressure, spraying dry;
(4) will remain other medical material decontaminations, cleaning, drying, made medical material pulverizes and sieves together with dry thing with step (1) (2) (3), and gained medicated powder and pharmaceutical excipients mix, pill block, ball bar, gradation, round, dry, obtains pill.
The preparation method of the Chinese medicine preparation pill of described treatment rheumatic arthralgia, heavy 0.2-0.4 gram of the made pill every of step (4) (preferred, pill every is heavy 0.3 gram).
The preparation method of described capsule is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak and (preferably, soak 40-50 minute in 30-60 minute; Be more preferably, soak 45 minutes), heating is boiled, and turns little fire and decocts, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, heating is concentrated into clear paste, and mixes with step (3) gained clear paste, adds adjuvant and makes soft material, and cross 12 mesh sieves and granulate, dry, granulate, incapsulates, and obtains capsule.
The preparation method of the Traditional Chinese medicine preparation capsule agent of described treatment rheumatic arthralgia, heavy 0.3-0.5 gram of the every capsules of step (5) (preferred, every capsules weighs 0.4 gram).
The Chinese medicine preparation for the treatment of rheumatic arthralgia provided by the invention is according to Chinese medicine principle scientific formula, and the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, invention formulation is made up of Chinese medicine material, and safety is without any side effects;
2, this prescription develops in conjunction with traditional Chinese medical science principle of medication according to the morbidity pathology of rheumatic arthralgia patient, has the effects such as expelling wind and cold, promoting the flow of QI-blood by warming the meridian, benefiting vital QI and blood;
3, selected materials is cheap and easy to get, stable curative effect, effectively can alleviate patient pain.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Chuanxiong: base is former: be the dry rhizome of samphire Rhizoma Chuanxiong.Nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Semen Coicis: base is former: be the dry mature kernal of grass Semen Coicis.Nature and flavor: sweet, light, cool.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, and row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Herba Cirrohopetali Andersonii: base is former: be the herb of the orchid family volume lobe epidendrum comb cap volume lobe orchid.Composition: herb is containing bibenzyl composition: the blue bibenzyl of volume lobe is surely peaceful, large aspidistra phenol, and the blue bibenzyl of volume lobe is fixed, and the blue bibenzyl of volume lobe is peaceful, batatasins; Also containing luxuriant and rich with fragrance constituents: volume lobe Lan Feiding, volume lobe Lan Feiling.The property of medicine: warm in nature, sweet in the mouth, nontoxic ".Function cures mainly: cure mainly rheumatic arthralgia, traumatic injury, and cough is spitted blood, food stagnation, asthenia.Rhizoma Arisaematis: base is former: be the dry tuber of aroid Rhizoma Arisaematis, Arisaema heterophyllum B1., arisaema amurense Maxim.Bile Rhizoma Arisaematis (processed): get Rhizoma Arisaematis fine powder, adds clean Fel Bovis seu Bubali (or pig, sheep) and mixes thoroughly, and steam 60 minutes to thoroughly, taking-up cools, and makes fritter, dry.Nature and flavor: bitter, cool, low toxicity.Gui Jing: return lung, liver, spleen channel.Function cures mainly: removing heat-phlegm, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, acute infantile convulsion, epilepsy, tetanus.
Radix Dipsaci: base is former: be the dry root of Dipsacaceae plant Radix Dipsaci.Nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Fructus Arctii: base is former: be the dry mature fruit of feverfew Fructus Arctii.Nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Herba Melastomatis Dodecandri: base is former: be Genus Melastoma L. of Melastomataceae Herba Melastomatis Dodecandri herb.Nature and flavor: sweet, puckery are flat.Gui Jing: " east, Fujian book on Chinese herbal medicine ": " enter liver,kidney,spleen, lung four warp." function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, tonifying blood and arresting bleeding.For preventing the lonely inflammation of epidemic cerebrospinal, enteritis, dysentery, lung abscess, pelvic inflammatory disease, metrorrhagia, anemia, leucorrhea, lumbago and skelalgia, rheumatic ostalgia, traumatic hemorrhage, venom.
Herba Begoniae Laciniatae: base is former: be the Herb of Begoniaceae plant Begonia pedatifida.Nature and flavor: " Luchuan book on Chinese herbal medicine ": " sweet, cold." function cures mainly: cure cold cough, rheumatic ostalgia, lumbago, dyspepsia, treating swelling and pain by traumatic injury, furuncle.
Rhizoma Gymnadeniae: base is former: be the tuber of orchid Rhizoma Gymnadeniae and gymnadenia crassinervis Finet.Nature and flavor: sweet are flat.Gui Jing: " Chinese herbal medicine is commonly used in Sichuan ": " enter lung, spleen, stomach warp." function cures mainly: benefiting vital QI and blood, promoting the production of body fluid to quench thirst.Control cough and asthma due to lung deficiency, asthenia is become thin, neurasthenia, and chronic diarrhea is lost blood, leukorrhagia, and breast is few, chronic hepatitis.
Ramulus Cinnamomi: base is former: be the dry twig of canella Cortex Cinnamomi.Nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Function cures mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Herba Piperris Tonkinensis: base is former: be the Herb of Piperaceae Piper plant optical axis ramie leaf Betel.Composition: aerial parts contains: sitosterol, 4-alkene-6-hydroxyl-3-stigmastane ketone, ergosterol peroxide, alkaloid: piperine, Piperyline, Guinea piperamide A, B etc.The property of medicine: Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent, temperature." function cures mainly: expelling wind and cold, promoting blood flow to regulate menstruation, reducing swelling and alleviating pain.Cure mainly anemofrigid cold, rheumatic arthralgia, coldness and pain in the epigastrium, toothache, menoxenia, dysmenorrhea, treating swelling and pain by traumatic injury, snake bite and insect sting.
Herba stellariae mediae: base is former: the herb of Caryophyllaceae Stellaria plant Herba stellariae mediae.Nature and flavor: sweet, sour, cool.Function cures mainly: invigorate blood circulation, blood stasis removing, and stimulating milk secretion expedites the emergence of.The stagnant stomachache of the stasis of blood after managing property, milk is few, and summer-heat is vomitted, acute appendicitis, gonorrhea, malignant boil toxic swelling, traumatic injury.
Fructus Trichosanthis (drawing together building): base is former: be the fruit of cucurbitaceous plant Fructus Trichosanthis.Nature and flavor: sweetness and bitterness, cold.Gui Jing: enter lung, stomach, large intestine channel.Function cures mainly: lung moistening, reduces phlegm, eliminating stagnation, laxation.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.
embodiment 1the Chinese medicine preparation for the treatment of rheumatic arthralgia, is prepared from primarily of following bulk drugs: Rhizoma Chuanxiong 10g, Semen Coicis 12g, Herba Cirrohopetali Andersonii 9g, Rhizoma Arisaematis (bile system) 6g, Radix Dipsaci 10g, Fructus Arctii 15g, Herba Melastomatis Dodecandri 9g, Herba Begoniae Laciniatae 9g, Rhizoma Gymnadeniae 8g, Ramulus Cinnamomi 15g, Herba Piperris Tonkinensis 8g, Herba stellariae mediae 6g, Fructus Trichosanthis 15g.
The preparation method of the Chinese medicine preparation decoction of above-mentioned treatment rheumatic arthralgia is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, flood 14 hours at 50 DEG C, filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak 45 minutes, heating is boiled, and turns little fire and decocts 40 minutes, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, and add step (3) gained clear paste, stirring and evenly mixing, heating is concentrated into 1/2nd of original volume, obtains decoction.
The instructions of taking of decoction of the present invention: decoction is 15 days courses for the treatment of, takes every day twice (warm), each 50m1-70m1.
embodiment 2the Chinese medicine preparation for the treatment of rheumatic arthralgia, is prepared from primarily of following bulk drugs: Rhizoma Chuanxiong 20g, Semen Coicis 25g, Herba Cirrohopetali Andersonii 15g, Rhizoma Arisaematis (bile system) 10g, Radix Dipsaci 20g, Fructus Arctii 25g, Herba Melastomatis Dodecandri 16g, Herba Begoniae Laciniatae 12g, Rhizoma Gymnadeniae 15g, Ramulus Cinnamomi 20g, Herba Piperris Tonkinensis 12g, Herba stellariae mediae 10g, Fructus Trichosanthis 20g.
The preparation method of the Chinese medicine preparation powder for the treatment of rheumatic arthralgia is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, flood 14 hours at 50 DEG C, filter, lixiviate twice, merges twice filtrate, concentrating under reduced pressure, spraying dry;
(4) will remain other medical material decontaminations, cleaning, drying, made medical material pulverized 120 mesh sieves together with dry thing with step (1) (2) (3), obtained powder.
Model case: xxx, female, 36 years old.Main suit: when being confined in childbirth owing to bearing child, accidentally catch a cold, causes the large Minor articulus multiple pain of whole body 6 years, whenever suffering from cold, aggravation, takes analgesic, energy respite pain, but Relapse rate, suffers from cold recently, whole body many places size arthralgia, swelling, limitation of activity, numb limbs and tense tendons, myasthenia of limbs, then medical, during inspection, red tongue, white and thin fur, stringy pulse, is diagnosed as rheumatoid arthritis.
Take the Chinese medicine preparation powder of the present embodiment gained treatment rheumatic arthralgia, each one bag, every day 2 times, warm boiled water, 15 days courses for the treatment of.After taking two courses for the treatment of, arthralgia, swelling alleviate to some extent, and movable function slightly recovers, and after taking four courses for the treatment of, only have large joint mild pain, other malaise symptoms all disappear, a course for the treatment of of consolidate curative effect, and follow up a case by regular visits in two years, patient is not recurred.
embodiment 3the Chinese medicine preparation for the treatment of rheumatic arthralgia, is prepared from primarily of following bulk drugs: Rhizoma Chuanxiong 12g, Semen Coicis 16g, Herba Cirrohopetali Andersonii 11g, Rhizoma Arisaematis (bile system) 7g, Radix Dipsaci 12g, Fructus Arctii 17g, Herba Melastomatis Dodecandri 10g, Herba Begoniae Laciniatae 10g, Rhizoma Gymnadeniae 10g, Ramulus Cinnamomi 16g, Herba Piperris Tonkinensis 9g, Herba stellariae mediae 7g, Fructus Trichosanthis 17g.
The preparation method of the Chinese medicine preparation pill for the treatment of rheumatic arthralgia is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, flood 14 hours at 50 DEG C, filter, lixiviate twice, merges twice filtrate, concentrating under reduced pressure, spraying dry;
(4) other medical material decontaminations will be remained, cleaning, drying, made medical material pulverizes and sieves together with dry thing with step (1) (2) (3), and gained medicated powder and pharmaceutical excipients mix, pill block, ball bar, gradation, round, dry, obtain pill (every is heavy 0.3 gram).
Model case: xxx, female, 56 years old.Throw from stair because of carelessness the year before, left shoulder is dampened, after in pharmacy, bought plaster, remission, but over nearly two months, feel left shoulder pain, can not press, limitation of activity, left hand can not go up act, after revolve, abduction 60 °, night, pain increased the weight of, and sometimes even affected sleep, and there is swelling local, medical check, body of the tongue is slightly dark, white and thin fur, stringy pulse, the display of X sheet is without exception, is finally diagnosed as scapulohumeral periarthritis.
Take the Chinese medicine preparation pill of the present embodiment gained treatment rheumatic arthralgia, adopt twice daily, each 4-6, with warm water delivery service, 15 days courses for the treatment of.After taking a course for the treatment of, pain and swelling are slightly alleviated, and after taking two courses for the treatment of, movable function obviously recovers, and can go up and lift abduction 140 °, and after taking four courses for the treatment of, patient's shoulder arthralgia disappears, and freely, recovery from illness, so far there are no recurs in activity.
embodiment 4the Chinese medicine preparation for the treatment of rheumatic arthralgia, is prepared from primarily of following bulk drugs: Rhizoma Chuanxiong 18g, Semen Coicis 21g, Herba Cirrohopetali Andersonii 13g, Rhizoma Arisaematis (bile system) 9g, Radix Dipsaci 18g, Fructus Arctii 23g, Herba Melastomatis Dodecandri 15g, Herba Begoniae Laciniatae 11g, Rhizoma Gymnadeniae 13g, Ramulus Cinnamomi 19g, Herba Piperris Tonkinensis 11g, Herba stellariae mediae 9g, Fructus Trichosanthis 18g.
The preparation method of the Traditional Chinese medicine preparation capsule agent for the treatment of rheumatic arthralgia is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, flood 14 hours at 50 DEG C, filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak 45 minutes, heating is boiled, and turns little fire and decocts, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, heating is concentrated into clear paste, and mix with step (3) gained clear paste, add adjuvant and make soft material, cross 12 mesh sieves and granulate, dry, granulate, incapsulates, and every capsules weighs 0.4 gram, obtains capsule.
Model case: xxx, man, 60 years old, before 4 years after fatigue, occur that biped toe swells and ache, do not pay attention to, occur after half a year two ankle and knee joint stiff, swell and ache, blood examination rheumatoid factor positive, is diagnosed as rheumatoid arthritis, give antibiotic medicine (concrete name unknown) treatment, therapeutic effect is not obvious, rear drug withdrawal, then occurs both hands, biped joint deformity, red tongue tongue is white, deep-thready pulse.
Take the Traditional Chinese medicine preparation capsule agent of the present embodiment gained treatment rheumatic arthralgia after being introduced, adopt twice daily, each 5, with warm water delivery service, 15 days courses for the treatment of.After taking two courses for the treatment of, swell and ache and obviously alleviate, joint motion amplitude increases, and after taking four courses for the treatment of, patient swells and ache basic disappearance, tired or when suffering from cold, have pain, movable normal, sb.'s illness took a favorable turn, trend stability.
embodiment 5the Chinese medicine preparation for the treatment of rheumatic arthralgia, is prepared from primarily of following bulk drugs: Rhizoma Chuanxiong 15g, Semen Coicis 18.5g, Herba Cirrohopetali Andersonii 12g, Rhizoma Arisaematis (bile system) 8g, Radix Dipsaci 15g, Fructus Arctii 20g, Herba Melastomatis Dodecandri 12.5g, Herba Begoniae Laciniatae 10.5g, Rhizoma Gymnadeniae 11.5g, Ramulus Cinnamomi 17.5g, Herba Piperris Tonkinensis 10g, Herba stellariae mediae 8g, Fructus Trichosanthis 17.5g.
The preparation method of the Chinese medicine preparation decoction for the treatment of rheumatic arthralgia is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, flood 14 hours at 50 DEG C, filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak 45 minutes, heating is boiled, and turns little fire and decocts 40 minutes, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, and add step (3) gained clear paste, stirring and evenly mixing, heating is concentrated into 1/2nd of original volume, obtains decoction.
test example 1the clinical practice of the Chinese medicine preparation decoction (embodiment 5) of gained treatment rheumatic arthralgia of the present invention:
379 routine patients are screened, women 218 example, male 161 example from hospital's Orthopaedics Clinic case history, oldest 66 years old, minimal ages 41 years old, 56.4 years old mean age, course of disease 1-5, wherein rheumatic and patient with rheumatoid arthritis 203 example, scapulohumeral periarthritis patient 176 example.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, take every day twice (warm), each 50m1-70m1(adjusts to some extent depending on concrete condition), 15 days courses for the treatment of, matched group takes other medicine (Aspirin Enteric-coated Tablets, hold up him conventional medication such as sheet, diclofenac sodium enteric-coated tablets).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change, after five courses for the treatment of, and statistics treatment situation.
Curative effect situation criterion: rheumatic, rheumatoid arthritis: cure: affected joints is red, swollen, scorching hot, severe pain etc. disappears completely, function of joint is improved or is recovered normal, and erythrocyte sedimentation rate, rheumatoid factor recover normal; Effective: affected joints malaise symptoms alleviates, occasionally have outbreak, function of joint is improved, and erythrocyte sedimentation rate, rheumatoid factor titre decline; Invalid: pain and swelling symptom is without any improvement.
Scapulohumeral periarthritis: cure: shoulder pain disappears, and shoulder joint function recovers wholly or in part; Effective: shoulder pain alleviates, shoulder joint function improves; Invalid: pain is without improvement.
Table 1 liang component patient treatment outcome
Result after two groups of patient consumes's treatments is as shown in table 1, and experimental group total effective rate is 97.6%, and matched group total effective rate is 86.4%, and therapeutic effect is starkly lower than experimental group.More several conventional medicine of the therapeutic effect of visible products obtained therefrom of the present invention to rheumatic arthralgia is good.
Rhizoma Chuanxiong blood-activating and qi-promoting in formula of the present invention, wind-expelling pain-stopping effect; Semen Coicis clearing away heat and discharging pus, spleen invigorating eliminating dampness by diuresis; Dispeling the wind of Rhizoma Arisaematis convulsion, mass dissipating and swelling eliminating; Radix Dipsaci the kidney invigorating liver, bone and muscle strengthening; Fructus Arctii dispelling wind and heat pathogens, lung qi dispersing rash; Herba Melastomatis Dodecandri heat-clearing and toxic substances removing, expelling wind and removing dampness; Rhizoma Gymnadeniae benefiting vital QI and blood, promoting the production of body fluid to quench thirst; Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian; Herba Piperris Tonkinensis expelling wind and cold, reducing swelling and alleviating pain; Herba stellariae mediae blood circulation and promoting silt, all medicines share effects such as playing expelling wind and cold, promoting the flow of QI-blood by warming the meridian, benefiting vital QI and blood altogether, have significant curative effect for rheumatic arthralgia.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat the Chinese medicine preparation of rheumatic arthralgia, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Rhizoma Chuanxiong 10-20, Semen Coicis 12-25, Herba Cirrohopetali Andersonii 9-15, Rhizoma Arisaematis (bile system) 6-10, Radix Dipsaci 10-20, Fructus Arctii 15-25, Herba Melastomatis Dodecandri 9-16, Herba Begoniae Laciniatae 9-12, Rhizoma Gymnadeniae 8-15, Ramulus Cinnamomi 15-20, Herba Piperris Tonkinensis 8-12, Herba stellariae mediae 6-10, Fructus Trichosanthis 15-20.
2. the Chinese medicine preparation for the treatment of rheumatic arthralgia as claimed in claim 1, it is characterized in that, Rhizoma Chuanxiong 12-18, Semen Coicis 16-21, Herba Cirrohopetali Andersonii 11-13, Rhizoma Arisaematis (bile system) 7-9, Radix Dipsaci 12-18, Fructus Arctii 17-23, Herba Melastomatis Dodecandri 10-15, Herba Begoniae Laciniatae 10-11, Rhizoma Gymnadeniae 10-13, Ramulus Cinnamomi 16-19, Herba Piperris Tonkinensis 9-11, Herba stellariae mediae 7-9, Fructus Trichosanthis 17-18 is (preferred, Rhizoma Chuanxiong 15, Semen Coicis 18.5, Herba Cirrohopetali Andersonii 12, Rhizoma Arisaematis (bile system) 8, Radix Dipsaci 15, Fructus Arctii 20, Herba Melastomatis Dodecandri 12.5, Herba Begoniae Laciniatae 10.5, Rhizoma Gymnadeniae 11.5, Ramulus Cinnamomi 17.5, Herba Piperris Tonkinensis 10, Herba stellariae mediae 8, Fructus Trichosanthis 17.5).
3. the Chinese medicine preparation of the treatment rheumatic arthralgia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak and (preferably, soak 40-50 minute in 30-60 minute; Be more preferably, soak 45 minutes), heating is boiled, and turns little fire and decocts, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, and add step (3) gained clear paste, stirring and evenly mixing, heating is concentrated into 1/2nd of original volume, obtains decoction.
4. the preparation method of the Chinese medicine preparation decoction for the treatment of rheumatic arthralgia as claimed in claim 3, is characterized in that, step (4) turn little fire decocts 30-50 minute, and (preferred, 35-45 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 40 minutes).
5. the Chinese medicine preparation of the treatment rheumatic arthralgia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merges twice filtrate, concentrating under reduced pressure, spraying dry;
(4) will remain other medical material decontaminations, cleaning, drying, made medical material pulverizes and sieves together with dry thing with step (1) (2) (3), obtains powder.
6. the preparation method of the Chinese medicine preparation powder for the treatment of rheumatic arthralgia as claimed in claim 5, it is characterized in that, step (4) was pulverized 100-140 mesh sieve and (preferably, was pulverized 110-130 mesh sieve; Be more preferably, pulverized 120 mesh sieves).
7. the Chinese medicine preparation of the treatment rheumatic arthralgia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merges twice filtrate, concentrating under reduced pressure, spraying dry;
(4) will remain other medical material decontaminations, cleaning, drying, made medical material pulverizes and sieves together with dry thing with step (1) (2) (3), and gained medicated powder and pharmaceutical excipients mix, pill block, ball bar, gradation, round, dry, obtains pill.
8. the preparation method of the Chinese medicine preparation pill for the treatment of rheumatic arthralgia as claimed in claim 7, is characterized in that, heavy 0.2-0.4 gram of the made pill every of step (4) (preferred, pill every is heavy 0.3 gram).
9. the preparation method of the Chinese medicine preparation pill of the treatment rheumatic arthralgia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Fructus Arctii decontamination, be placed in parch container, rice wine sprinkling is evenly, slightly vexed, with slow fire heating, fries and heaves to micro-, have cracker, and when having fragrance to overflow, taking-up is dried in the air cool;
(2) will pick clean Semen Coicis, and clean, be placed in food steamer, steam to slightly soft, flatten, then stir to parching with saline, taking-up is dried in the air cool;
(3) by Herba Cirrohopetali Andersonii, Herba Begoniae Laciniatae, Rhizoma Gymnadeniae and Ramulus Cinnamomi decontamination, pulverize, with the dehydrated alcohol of medical material weight 6 times, at 50 DEG C, flood 10-18 hour (preferably, dipping 12-16 hour; Be more preferably, flood 14 hours), filter, lixiviate twice, merge twice filtrate, concentrating under reduced pressure becomes clear paste;
(4) other residue medical materials and step (1) (2) made medical material are placed in non iron container, add water and do not have medical material 3cm, soak and (preferably, soak 40-50 minute in 30-60 minute; Be more preferably, soak 45 minutes), heating is boiled, and turns little fire and decocts, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 40 minutes, filter, merge twice filtrate, heating is concentrated into clear paste, and mixes with step (3) gained clear paste, adds adjuvant and makes soft material, and cross 12 mesh sieves and granulate, dry, granulate, incapsulates, and obtains capsule.
10. the preparation method of the Traditional Chinese medicine preparation capsule agent for the treatment of rheumatic arthralgia as claimed in claim 9, is characterized in that, heavy 0.3-0.5 gram of the every capsules of step (5) (preferred, every capsules weighs 0.4 gram).
CN201510003549.0A 2015-01-06 2015-01-06 Traditional Chinese medicine preparation for treating rheumatic joint pain and preparation Pending CN104435899A (en)

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Citations (4)

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CN101972453A (en) * 2010-10-29 2011-02-16 韩世昌 Chinese medicinal liquor for treating rheumatic and rheumatoid arthritis and preparation method thereof
CN102441123A (en) * 2010-10-09 2012-05-09 田荣春 Medicine for treating rheumarthritis
KR20140115747A (en) * 2013-03-22 2014-10-01 김석말 pill manufacture method using palm tree fruit

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CN101020012A (en) * 2007-03-16 2007-08-22 宗宪山 Recipe of externally applied Chinese medicine liquid prepn for treating rheumatic and rheumatoid pain
CN102441123A (en) * 2010-10-09 2012-05-09 田荣春 Medicine for treating rheumarthritis
CN101972453A (en) * 2010-10-29 2011-02-16 韩世昌 Chinese medicinal liquor for treating rheumatic and rheumatoid arthritis and preparation method thereof
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