CN104435096A - Abrus cantoniensis hepatitis granules and preparation method thereof - Google Patents
Abrus cantoniensis hepatitis granules and preparation method thereof Download PDFInfo
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- CN104435096A CN104435096A CN201410702358.9A CN201410702358A CN104435096A CN 104435096 A CN104435096 A CN 104435096A CN 201410702358 A CN201410702358 A CN 201410702358A CN 104435096 A CN104435096 A CN 104435096A
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- 239000008187 granular material Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 244000135727 Abrus pulchellus subsp cantoniensis Species 0.000 title abstract description 7
- 235000017112 Abrus pulchellus subsp cantoniensis Nutrition 0.000 title abstract 6
- 208000006454 hepatitis Diseases 0.000 title abstract 5
- 231100000283 hepatitis Toxicity 0.000 title abstract 5
- 239000000843 powder Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920001353 Dextrin Polymers 0.000 claims abstract description 9
- 239000004375 Dextrin Substances 0.000 claims abstract description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 9
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 9
- 235000019425 dextrin Nutrition 0.000 claims abstract description 9
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008101 lactose Substances 0.000 claims abstract description 9
- 206010023126 Jaundice Diseases 0.000 claims abstract description 7
- 208000037319 Hepatitis infectious Diseases 0.000 claims abstract description 6
- 230000001154 acute effect Effects 0.000 claims abstract description 6
- 208000005252 hepatitis A Diseases 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims description 21
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 8
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 8
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 8
- 229940113124 polysorbate 60 Drugs 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 8
- 244000294611 Punica granatum Species 0.000 abstract description 3
- 235000014360 Punica granatum Nutrition 0.000 abstract description 3
- 241000092668 Artemisia capillaris Species 0.000 abstract description 2
- 235000008658 Artemisia capillaris Nutrition 0.000 abstract description 2
- 240000002505 Pogostemon cablin Species 0.000 abstract description 2
- 235000011751 Pogostemon cablin Nutrition 0.000 abstract description 2
- 238000002137 ultrasound extraction Methods 0.000 abstract 2
- 244000219416 Hypericum japonicum Species 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241001249148 Artemisia scoparia Species 0.000 description 2
- 235000003069 Artemisia scoparia Nutrition 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 208000013219 diaphoresis Diseases 0.000 description 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000219991 Lythraceae Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 239000001138 artemisia absinthium Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 229940119177 germanium dioxide Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses abrus cantoniensis hepatitis granules and a preparation method thereof. The abrus cantoniensis hepatitis granules are characterized in that 550 g of pogostemon cablin, 280 g of pomegranate bark, 469 g of abrus cantoniensis, 469 g of artemisia capillaris and 469 g of hypericum japonicum are smashed into coarse powder and placed in a circulatory ultrasonic extraction device, water, germanium powder and tween 60 are added and subjected to ultrasonic extraction, jet spray drying is performed, nano-scale extracted powder is prepared, lactose and dextrin are added, the abrus cantoniensis hepatitis granules are prepared and used for treating jaundice type or jaundice-free type acute infectious hepatitis and has a better treatment effect than abrus cantoniensis hepatitis granules sold in the market, and a good effect is obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Guanule contg. ' Jigucao granule and preparation method thereof.
Background technology
Guanule contg. ' Jigucao granule soothing liver-QI, heat clearing away, dampness removing, Huang of dispelling.For jaundice and non-icteric type acute infectious hepatitis.Commercially available Guanule contg. ' Jigucao granule is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention for overcoming above-mentioned deficiency, Guanule contg. ' Jigucao granule providing a kind of curative effect high and preparation method thereof.
Invention embodiment is as follows:
Get Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 8 ~ 10g germanium powder, 2 ~ 4g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Herba Pogostemonis: China's coastal port one ministerial standard.This product is that labiate extensively stores fragrant Pogostemon cablin(Blanco) dry aerial parts of Benth..Tap when branch and leaf are luxuriant, Exposure to Sunlight is vexed for night, repeatedly to dry.
Pericarpium Granati: China's coastal port one ministerial standard.This product is the dry peel of Punicaceae plant Punica granatum L. Punica granatum L..Autumn collects peel after fruit maturation, dries.
Herba Abri: China's coastal port one ministerial standard.This product is the dry Herb of leguminous plant abrus cantoniensis Hance Abrus cantoniensis Hance.The whole year all can excavate, removing silt, dry.
Herba Artemisiae Scopariae: China's coastal port one ministerial standard.This product is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst.et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Gather during seedling height 6-10cm in spring or autumn, alabastrum grew up to time tap, removing impurity and old stem, dries.The habit of gathering spring claims " capillary wormwood ", the title " Herba Artemisiae Scopariae " tapped autumn.This product is On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.Excavate more than the 7-9 month, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria block ".
Herba Hyperici Japonici: Chinese Pharmacopoeia version one ministerial standard in 1977.
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
Lactose: Chinese Pharmacopoeia version two ministerial standard in 2010;
Dextrin: Chinese Pharmacopoeia version two ministerial standard in 2010;
Pulvis Talci: Chinese Pharmacopoeia version one ministerial standard in 2010;
Raw material used by above Guanule contg. ' Jigucao granule all can be bought from pharmaceuticals and obtain, and is not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
Raw material used by above Guanule contg. ' Jigucao granule all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 8g germanium powder, 2g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
Specific embodiments of the invention 2
Get Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 10g germanium powder, 4g polysorbate60, select supersonic frequency 60KHz, pressure 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04 Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
Specific embodiments of the invention 3
Get Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 9g germanium powder, 3g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Guanule contg. ' Jigucao granule.Actual effect of the present invention is investigated below with the Guanule contg. ' Jigucao granule that embodiment 3 is obtained:
(1) embodiment 3 Guanule contg. ' Jigucao granule and commercially available Guanule contg. ' Jigucao granule therapy jaundice and non-icteric type acute infectious hepatitis Disease Clinical observation of curative effect
1 case scenario
Statistics outpatient service and inpatient, observe jaundice and non-icteric type acute infectious hepatitis case 106 example, 32 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 Guanule contg. ' Jigucao granule, and matched group takes traditional Guanule contg. ' Jigucao granule.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 1 embodiment 3 Guanule contg. ' Jigucao granule and the contrast of commercially available Guanule contg. ' Jigucao granule clinical efficacy
Above-mentioned clinical observation on the therapeutic effect result shows, Guanule contg. ' Jigucao granule prepared by the present invention is when treating jaundice and non-icteric type acute infectious hepatitis, evident in efficacy higher than commercially available Guanule contg. ' Jigucao granule, p < 0.05.
Claims (3)
1. treat a Chinese medicine for jaundice and non-icteric type acute infectious hepatitis, it is characterized in that getting Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 8 ~ 10g germanium powder, 2 ~ 4g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 8 ~ 10g germanium powder, 2 ~ 4g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Pogostemonis 550g, Pericarpium Granati 280g, Herba Abri 469g, Herba Artemisiae Scopariae 469g, Herba Hyperici Japonici 469g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 22370g water, 9g germanium powder, 3g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 600g, DEXTRIN 0g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 30g, mixing, obtained Guanule contg. ' Jigucao granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410702358.9A CN104435096A (en) | 2014-11-29 | 2014-11-29 | Abrus cantoniensis hepatitis granules and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410702358.9A CN104435096A (en) | 2014-11-29 | 2014-11-29 | Abrus cantoniensis hepatitis granules and preparation method thereof |
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| CN104435096A true CN104435096A (en) | 2015-03-25 |
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| CN201410702358.9A Withdrawn CN104435096A (en) | 2014-11-29 | 2014-11-29 | Abrus cantoniensis hepatitis granules and preparation method thereof |
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