CN104398653A - 一种治疗牙痛的药物及其制备方法 - Google Patents
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Abstract
一种治疗牙痛的药物及其制备方法,它是由荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连、银花、连翘、野菊花、蒲公英按照一定的重量份数配比配伍而成。本发明药物的制剂形态为胶囊剂、片剂或丸剂。本发明药物对治疗清热解毒,消肿止痛,牙痛、口腔溃疡、牙龈肿痛、牙龈出血等具有特殊疗效,而且本发明药物疗效迅速,疗程短。可治疗因体内积火而致的各种牙痛。
Description
技术领域
本发明涉及一种以中草药为原料的中成药及其制剂制备方法,具体的说是一种治疗牙痛的药物及其制备方法。
背景技术
牙疼症也叫牙痛症是一种常见疾病。其表现为:牙龈红肿、遇冷热刺激痛、面颊部肿胀等。牙痛大多由牙龈炎和牙周炎、龋齿(蛀牙)或折裂牙而导致牙髓(牙神经)感染所引起的。都说牙痛不是病,痛起来要人命。相信有过牙痛经历的人肯定对这句话深有感触。受现代生活之害,很多人因忙于工作,生活作息不规律,再加上经常熬夜加班,所以出现口腔问题的不在少数,如口腔溃疡、牙疼、牙龈肿痛、牙龈出血等。中医学认为,牙痛是由于外感风邪、胃火炽盛、肾虚火旺、虫蚀牙齿、肝火旺盛等原因所致。牙龈炎是常见的牙周组织疾病。目前多数使用镇痛剂外加消炎性西药如抗生素来治疗,西药虽然药效快,但副作用比较大,而且仅仅能短暂治愈疼痛,虽然短暂能治标但是达不到治本的效果。
发明内容
本发明从临床医疗用药需求及中医组方辩证原则出发,提供一种治疗牙痛的药物,旨在提供给一种既能够有效治疗或缓解牙痛,有能够消除体内积火的中药组合物。主治外感风邪、胃火炽盛、肾虚火旺、肝火旺盛等上火,以及牙龈炎等引起的牙齿肿痛。它是由以下重量份数配比的原料药制备而成的药剂:荆芥4-8份、防风4-8份、生石膏30-50份、丹皮4-8份、甘草4-8份、生地8-12份、青皮4-8份、升麻4-8份、黄连2-5份。当患者牙疼有脓肿时,加入金银花4-8份、连翘4-8份、野菊花4-8份、蒲公英4-8份。
荆芥6份、防风6份、生石膏40份、丹皮6份、甘草6份、生地10份、青皮6份、升麻6份、黄连3份。当患者牙疼有脓肿时,加入金银花6份、连翘6份、野菊花6份、蒲公英6份。
所述治疗牙痛的药物制剂的形态为:汤剂、胶囊剂、片剂或丸剂。
所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
本发明经过大量临床应用,对治疗肾火、胃火、脾火、肝火、胆火、大肠火、肺火引起的牙齿疼痛有非常好的疗效,对牙齿脓肿、牙龈发炎也有很好的治疗效果。
为了更好的理解本发明,以下进一步阐述本发明药物在药理和临床上的作用效果。
本发明药物原料药药理:
荆芥:味辛,性微温。归肺、肝经。【功效主治】解表散风,透疹,消疮。用于感冒,头痛,麻疹,风疹,疮疡初起。可用于牙宣疳。
防风:味辛、甘,性微温。归膀胱、肺、脾、肝经。【功效主治】祛风解表,胜湿止痛,止痉。用于外感表证,风疹瘙痒,风湿痹痛,破伤风正,脾虚湿盛。
生石膏:(清热泻火药 )辛、甘,微寒。归肺、胃经。清热泻火, 除烦止渴,收敛生肌。【主治】中风寒热,心下逆气惊喘,口干舌焦,不能息,腹中坚痛,除邪鬼,产褥金 疮。除时气头痛身热,三焦大热,皮肤热,肠胃中结气,解肌发汗,止消渴烦逆,腹胀暴气,喘息咽热,亦可做浴汤。治伤寒头疼如裂。和葱煎茶,去头疼。治天行狂热,头风旋,下乳,揩齿益齿。除胃热肺热,散阴邪,缓脾益气。止阳明经头疼,发热恶寒,日哺潮热,大渴引饮,中暑潮热,牙疼。 用于胃火亢盛,头痛,齿痛,牙龈肿痛。
丹皮:性寒,味苦;凉;微寒。归心;肝;肾;肺经。清热凉血;活血散瘀。温热病热入血分;发斑;吐衄;热泪盈眶病菌后期热伏阴分发热;阴虚骨蒸潮热;血滞经闭;痛经;痈肿疮毒;跌扑伤痛;风湿热痹。现代药效学证实,丹皮具有抗炎、抑菌作用。
抗炎作用:用丹皮酚灌胃,对大鼠因右旋糖酐或醋酸或角叉菜胶引起的足跖浮肿有抑制作用,并能抑制醋酸或5-羟色胺引起的小鼠腹腔或豚鼠皮肤毛细血管通透性增强,抑制小鼠应激性溃疡的发生。实验证明丹皮水煎剂对角叉菜胶性浮肿、佐剂性关节炎及Arthus反应等所致多种炎症反应具有抑制作用,这与其抑制炎症组织的通透性和抑制PGE2的生物合成有关,丹皮不能抑制残存肾上腺的代偿性增生,对肾上腺维生素C的代谢也无明显影响,提示它既无类可的松样的作用,也无类促肾上腺皮质激素样作用,即其抗炎作用不依赖于垂体肾上腺系统。Ⅰ、Ⅱ、Ⅲ型变态反应是由特异性抗体介导的反应,丹皮对抗体的形成并无明显影响,但对之均有抑制作用,可能是通过非特异性抗炎机制发挥作用,而抑制血清补体活性,也就增强其抗炎效应。
抑菌作用:体外实验表明,牡丹皮煎剂对枯草杆菌、大肠杆菌、伤寒杆菌、副伤寒杆菌、变形杆菌、绿脓杆菌、葡萄球菌、溶血性链球菌、肺炎球菌、霍乱弧菌等均有较强的抗菌作用,牡丹叶煎剂对痢疾杆菌、绿脓杆菌和金黄色葡萄球菌有显著抗菌作用,其有效成份为没食子酸。
甘草:味甘平。主五脏六府寒热邪气,坚筋骨,长肌肉,倍力,金创,解毒。西医药理发现,甘草剂有抗炎和抗变态反应的功能,因此在西医临床上主要作为缓和剂。缓解咳嗽,祛痰,治疗咽痛喉炎;甘草或甘草次酸有去氧皮质酮类作用,对慢性肾上腺皮质功能减退症有良好功效;甘草制剂能促进胃部粘液形成和分泌,延长上皮细胞寿命,有抗炎活性,常用于慢性溃疡和十二指肠溃疡的治疗;甘草的黄酮具有消炎、解痉和抗酸作用。
生地:甘,寒。归心,肝,肾经。【功效主治】具有清热凉血功效,用于温热病热入营血,壮热神昏,口干舌绛。
青皮:味苦、辛,性温。归肝、胆、胃经。【功效主治】有疏肝破气,消积化滞的功效。用于胸胁胀痛,疝气疼痛,乳癖,乳痈,食积气滞,脘腹胀痛。
升麻:辛、甘,微寒。归肺、脾、大肠、胃经。【功效主治】发表透疹,清热解毒,升阳举陷。时气疫疠,头痛寒热,喉痛,口疮,斑疹不透;中气下陷,久泻久痢,脱肛,妇女崩、带,子宫下坠;痈肿疮毒。
黄连:味苦,性寒。归心、脾、胃、肝、胆、大肠经。【功效主治】清热燥湿,泻火解毒。湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,心悸不宁,血热吐衄,目赤,牙痛,消渴,痈肿疗疮;外治湿疹,湿疮,耳道流脓。
金银花:金银花自古以来就以它的药用价值广泛而著名。其功效主要是清热解毒,主治温病发热、热毒血痢、痈疽疔毒等。现代研究证明,金银花含有绿原酸、木犀草素苷等药理活性成分,对溶血性链球菌、金黄葡萄球菌等多种致病菌及上呼吸道感染致病病毒等有较强的抑制力,另外还可增强免疫力、抗早孕、护肝、抗肿瘤、消炎、解热、止血(凝血)、抑制肠道吸收胆固醇等。金银花常与蒲公英、紫地丁、野菊花等同用,能增强清热解毒作用,可用以痈疽疔毒,红肿疼痛,如五味消毒饮。
连翘:苦,凉。入心、肝、胆经。【功效主治】清热,解毒,散结,消肿。治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。
野菊花:性温;辛、苦;归肺、肝经。【功效主治】清热解毒;疏风平肝;消肿。对金黄色葡萄球菌、白喉杆菌、链球菌、绿脓杆菌、蒺疾杆菌、流感病毒,均有抑制作用。
蒲公英:性味:苦甘,寒。归经:入肝、胃经。功能主治:清热解毒,利尿散结。治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。
本发明药物各原料药,君臣佐使配伍用药,能够清热解毒,消炎消肿,清热泻火,止血止痛,对治疗肾火、胃火、脾火、肝火、胆火、大肠火、肺火等上火引起的牙齿疼痛,有非常好的疗效,对牙齿脓肿、牙龈发炎也有很好的治疗效果。
临床研究情况:
张某某,男,31岁,诉右上领后牙自发性疼痛3天,冷热刺激时加重,诊见右面部肿胀,张口约一指,伴头痛,口臭。患牙周围牙龈充血,水肿,触痛明显。给予服用本发明的药物,早晚各一次,服用1剂后即有缓解,连服3天后炎症消失,康复如常。
李某某,男,45岁,诉左上牙痛,诊见牙龈红肿,舌苔黄厚,测量体温38.5℃。问诊诉口苦、便秘,牙根钻心疼痛,触之不得。给予服用本发明的药物,早晚各一次,服用2天后即消肿止痛,康复如常。
赵某某,女,21岁,诉近两日自发性牙痛,白天减轻,夜间加重,疼痛难忍,自服阿莫西林后有所缓解,但不能痊愈。诊见面部肿胀,左下牙牙龈红肿,口臭,小便赤黄,大便干结。给予服用本发明的药物,早晚各一次,服用2天后疼痛消失,康复如常。
杜某某,男,36岁,诉右侧牙痛一月余,加重两天,火烧火燎,颌肿咽痛,坐卧不安。诊见牙龈肿胀出血,溃烂溢脓,口气热臭,苔黄脉洪。患者平时喜食辛辣之食物,常熬夜,生活作息不规律。给予服用本发明的药物,早晚各一次,服用2天后症状缓解,继续服用5天后康复如常。
经过临床实验统计,对用本发明药物治疗牙痛病人206例进行实验,统计结果显示,本发明药物治疗牙痛成效显著,疗效率达100.00%,治愈率在90.78%。试验方法如下:
一、 选择病例:2012-2013年前来就诊的牙痛患者;
二、 诊断标准:牙痛、牙龈肿痛;
三、 治疗方案:连续服用本药物2个疗程,4天为一个疗程;
四、 疗效评价标准:牙痛症状消失、牙痛症状缓解为有疗效,牙痛症状消失为治愈;
五、 统计结果:见下表,
患者人数 | 牙痛症状消失 | 牙痛症状缓解 | 疗效率 | 治愈率 |
206人 | 187 | 19 | 100.00% | 90.78% |
统计结果显示,本发明药物收效甚佳,疗效率达100.00%,治愈率在90.78%以上。本药物对缓解或治疗牙痛有较好的效果。
具体实施方式
实施例1:一种既能够有效治疗或缓解牙痛,有能够消除体内积火的中药组合物。它是由以下重量份数配比的原料药制备而成的药剂:荆芥4-8份、防风4-8份、生石膏30-50份、丹皮4-8份、甘草4-8份、生地8-12份、青皮4-8份、升麻4-8份、黄连2-5份。
其汤药熬制方法如下:
泡:熬中药之前必须要充分的泡,就是要把中药放到砂锅中,倒上水浸泡两小时以上,让药材吸入充分的水分。具体而言,取方中药物荆芥4-8份、防风4-8份、生石膏30-50份、丹皮4-8份、甘草4-8份、生地8-12份、青皮4-8份、升麻4-8份、黄连2-5份均匀参在一起形成组合药材,将组合药材混合均匀后放到砂锅中,倒上水浸泡两小时以上,让组合药材吸入充分的水分。
熬:把浸泡两小时以上组合药材的砂锅放在煤气上,(记住熬中药好不能用电磁炉。否则药性会丧失殆尽!)打开火,等开锅后,把火调小。保持开锅就行。边熬上述组合药材,边时不时的搅拌,熬到大约25分钟后,关掉火。等药慢慢变凉后把砂锅下来。把药水慢慢倒入碗中。如果熬制到少半碗就成功了,太多太少都不好。然后,把带有组合药材的砂锅再倒入一碗水,放到煤气罩上熬制第二料。
所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
实施例2:一种既能够有效治疗或缓解牙痛,有能够消除体内积火的中药组合物。它是由以下重量份数配比的原料药制备而成的药剂:荆芥4-8份、防风4-8份、生石膏30-50份、丹皮4-8份、甘草4-8份、生地8-12份、青皮4-8份、升麻4-8份、黄连2-5份。当患者牙疼有脓肿时,加入金银花4-8份、连翘4-8份、野菊花4-8份、蒲公英4-8份。
其汤药熬制方法如下:
泡:熬中药之前必须要充分的泡,就是要把中药放到砂锅中,倒上水浸泡两小时以上,让药材吸入充分的水分。具体而言,取方中药物荆芥4-8份、防风4-8份、生石膏30-50份、丹皮4-8份、甘草4-8份、生地8-12份、青皮4-8份、升麻4-8份、黄连2-5份、金银花4-8份、连翘4-8份、野菊花4-8份、蒲公英4-8份均匀参在一起形成组合药材,将组合药材混合均匀后放到砂锅中,倒上水浸泡两小时以上,让组合药材吸入充分的水分。
熬:把浸泡两小时以上组合药材的砂锅放在煤气上,(记住熬中药好不能用电磁炉。否则药性会丧失殆尽!)打开火,等开锅后,把火调小。保持开锅就行。边熬上述组合药材,边时不时的搅拌,熬到大约25分钟后,关掉火。等药慢慢变凉后把砂锅下来。把药水慢慢倒入碗中。如果熬制到少半碗就成功了,太多太少都不好。然后,把带有组合药材的砂锅再倒入一碗水,放到煤气罩上熬制第二料。
所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连、麦冬、知母、黄柏、金银花、连翘、野菊花、蒲公英粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
实施例3:一种既能够有效治疗或缓解牙痛,有能够消除体内积火的中药组合物。它是由以下重量份数配比的原料药制备而成的药剂:荆芥6份、防风6份、生石膏40份、丹皮6份、甘草6份、生地10份、青皮6份、升麻6份、黄连3份。
其汤药熬制方法如下:
泡:熬中药之前必须要充分的泡,就是要把中药放到砂锅中,倒上水浸泡两小时以上,让药材吸入充分的水分。具体而言,取方中药物荆芥6份、防风6份、生石膏40份、丹皮6份、甘草6份、生地10份、青皮6份、升麻6份、黄连3份均匀参在一起形成组合药材,将组合药材混合均匀后放到砂锅中,倒上水浸泡两小时以上,让组合药材吸入充分的水分。
熬:把浸泡两小时以上组合药材的砂锅放在煤气上,(记住熬中药好不能用电磁炉。否则药性会丧失殆尽!)打开火,等开锅后,把火调小。保持开锅就行。边熬上述组合药材,边时不时的搅拌,熬到大约25分钟后,关掉火。等药慢慢变凉后把砂锅下来。把药水慢慢倒入碗中。如果熬制到少半碗就成功了,太多太少都不好。然后,把带有组合药材的砂锅再倒入一碗水,放到煤气罩上熬制第二料。
所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
实施例4:一种既能够有效治疗或缓解牙痛,有能够消除体内积火的中药组合物。它是由以下重量份数配比的原料药制备而成的药剂:荆芥6份、防风6份、生石膏40份、丹皮6份、甘草6份、生地10份、青皮6份、升麻6份、黄连3份。当患者牙疼有脓肿时,加入金银花6份、连翘6份、野菊花6份、蒲公英6份。
其汤药熬制方法如下:
泡:熬中药之前必须要充分的泡,就是要把中药放到砂锅中,倒上水浸泡两小时以上,让药材吸入充分的水分。具体而言,取方中药物荆芥6份、防风6份、生石膏40份、丹皮6份、甘草6份、生地10份、青皮6份、升麻6份、黄连3份、金银花6份、连翘6份、野菊花6份、蒲公英6份均匀参在一起形成组合药材,将组合药材混合均匀后放到砂锅中,倒上水浸泡两小时以上,让组合药材吸入充分的水分。
熬:把浸泡两小时以上组合药材的砂锅放在煤气上,(记住熬中药好不能用电磁炉。否则药性会丧失殆尽!)打开火,等开锅后,把火调小。保持开锅就行。边熬上述组合药材,边时不时的搅拌,熬到大约25分钟后,关掉火。等药慢慢变凉后把砂锅下来。把药水慢慢倒入碗中。如果熬制到少半碗就成功了,太多太少都不好。然后,把带有组合药材的砂锅再倒入一碗水,放到煤气罩上熬制第二料。
所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连、金银花、连翘、野菊花、蒲公英粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
实施例5:实施例1-4中,所述的治疗牙痛的药物制剂形态为胶囊剂、片剂或丸剂时,步骤(2)中所述的混合物,加水煎煮的次数最佳为2次,第一次为60-80分钟,第二次为40-60分钟。
实施例6:本发明药物还可以为口服液、颗粒剂等。
Claims (9)
1.一种治疗牙痛的药物,其特征在于它是由以下重量份数配比的原料药制备而成的药剂:荆芥4-8份、防风4-8份、生石膏30-50份、丹皮4-8份、甘草4-8份、生地8-12份、青皮4-8份、升麻4-8份、黄连2-5份。
2.根据权利要求1所述的治疗牙痛的药物,其特征在于它还包括以下重量份数配比的原料药:金银花4-8份、连翘4-8份、野菊花4-8份、蒲公英4-8份。
3.根据权利要求1所述的治疗牙痛的药物,其特征在于它是由以下重量份数配比的原料药制备而成的药剂:荆芥6份、防风6份、生石膏40份、丹皮6份、甘草6份、生地10份、青皮6份、升麻6份、黄连3份。
4.根据权利要求3所述的治疗牙痛的药物,其特征在于它还包括以下重量份数配比的原料药:金银花6份、连翘6份、野菊花6份、蒲公英6份。
5.根据权利要求1或3所述的治疗牙痛的药物,其特征在于其制剂的形态为汤剂、胶囊剂、片剂或丸剂。
6.根据权利要求2或4所述的治疗牙痛的药物,其特征在于其制剂的形态为胶囊剂、片剂或丸剂。
7.根据权利要求5所述的治疗牙痛的药物,其特征在于所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
8.根据权利要求6所述的治疗牙痛的药物,其特征在于所述胶囊、丸剂、片剂制备方法步骤如下:
(1)取方中荆芥、防风、生石膏、丹皮、甘草、生地、青皮、升麻、黄连、金银花、连翘、野菊花、蒲公英粉碎筛析;
(2)将步骤(1)中筛制的混合物加水煎煮2-3次,合并煎液、过滤,将虑液浓缩成70-80度时,胶囊、丸剂相对密度为1.0-1.6的稠膏,片剂相对密度为1.0-1.4的稠膏;
(3)制作胶囊、丸剂时:
将稠膏分离纯化、干燥,制成干颗粒;将干颗粒混合均匀,填充胶囊内即制成胶囊;将干颗粒喷加炼蜜、混合均匀,制成小丸即制成丸剂;
制作片剂时:
将2-4份淀粉与步骤(2)中的稠膏混合均匀,制成颗粒、干燥,制成干颗粒,将干颗粒压制成片剂,包糖衣,即制成片剂。
9.根据权利要求7或8所述的治疗肾炎水肿的药物的制备方法,其特征在于步骤(2)中所述的混合物,加水煎煮的次数为2次,第一次为60-80分钟,第二次为40-60分钟。
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