CN104394931A - Method and system for tms dose assessment and seizure detection - Google Patents
Method and system for tms dose assessment and seizure detection Download PDFInfo
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Abstract
A method of and system for monitoring a patient's EEG (electroencephalogram) during TMS (Transcranial Magnetic Stimulation) are disclosed. The system comprises a TMS device to generate, when in an active state, a plurality of magnetic pulses, which can be applied either as a burst, comprising a plurality of pulses grouped together, or as individual pulses, to the patient's head, in accordance with a TMS treatment protocol. An EEG system is provided to measure EEG data resulting from the TMS treatment protocol being applied to the patient. The system further comprises control means in communication with the TMD device and the EEG system, the control means being arranged to activate the EEG system during the time periods when the TMS device is not generating pulses, such that the EEG data measurement is continuously applied or interleaved with the magnetic pulses being generated in accordance with the TMS treatment protocol, so as to monitor treatment efficacy and detect potential seizures.
Description
Technical field
The present invention relates to the method and apparatus detected for TMS dose assessment and sudden illness.
Background technology
Transcranial magnetic stimulation (TMS) is the technology for non-invasively stimulating human brain.Particularly, TMS causes depolarization or hyperpolarization in the neuron of brain.By changing magnetic field fast, TMS utilizes electromagnetic induction to weak current of inducting; This can cause the activity at the specific or conventional position of brain with minimum sense of discomfort, thus permission is studied the function of brain and interconnection.Therefore, TMS utilizes principle of induction to obtain the electric energy crossing over scalp and skull, and without the pain of direct transcutaneous electrostimulation.It relates to and wire coils to be placed on scalp and to allow fast-changing heavy current through this coil.This generates can not be interrupted and relatively painlessly through the magnetic field of head tissue.Correspondingly, this magnetic field generates much faint electric current at brain.In order to enough electric currents of inducting carry out the neuron of depolarization brain, the electric current flowing through excitation coil must start, stop or reverse its direction within hundreds of microsecond.
At present, TMS is used with several different form.In the first form being called pulse TMS, the magnetic energy of individual pulse is sent to patient from coil.In another kind of form and repeatedly TMS (rTMS), train of pulse is transmitted with various frequency mode in a special time period.Frequency sequence has raised the irritability of Cerebral cortex, and uses this pattern to be have superiority in some disease (as depression).But high frequency mode has the potentiality improving sudden illness risk.Be documented in the international common recognition file people such as people, Wassermann in 1996 such as (such as, shown) Rossi in 2009 for the safety restriction of stimulus intensity and frequency.
In order to monitor safety and the effectiveness of TMS application, a kind of known method is during TMS application and afterwards with the state of mode monitored patient intuitively.Obtain this subjective evaluation for security purpose thus, and this assessment is usually based on questionnaire table.But this can not get the online feedback for treatment effectiveness, and this scheme cannot detect sudden illness in time.
The safety of monitoring TMS application and another known method of effectiveness are the electroencephalograms of before the TMS stage and afterwards monitored patient.
Electroencephalogram (EEG) is the record of the specific brain regions wave pattern to patient.EEG system allows to carry out record to brain wave patterns.EEG system generally includes the multiple conductive electrodes be placed on patient's scalp.These electrodes are generally metal and are connected on preamplifier, wherein this preamplifier process by electrode detection to signal and amplifying signal is supplied to EEG machine.EEG machine comprises hardware and software, its to signal make an explanation to provide by electrode detection to the visual display of brainwave activity.This brainwave activity is usually displayed on band monitor or computer monitor.
In practice, the employing of EEG relates to before the TMS stage and measures through induced response afterwards, and subsequently after the TMS stage to spontaneous EEG or non magnetic through bring out EEG response measure.But adopting EEG to measure after TMS treatment stage can the whole treatment stage of significant prolongation.
The safety of monitoring TMS application and the another known method of effectiveness are the electroencephalograms of monitored patient during the TMS stage.But, in TMS pulse process, technical problem is existed to the monitoring of patient's electroencephalogram: TMS Campatible EEG system usually can not adapt to TMS and measure, because the high-energy dynamic magnetic field produced by TMS equipment generates less desirable voltage in electroencephalogram lead-in wire, thus the use of traditional E EG hardware is caused to be unsuitable for securely and effectively monitoring TMS treatment.Particularly, it is saturated that the preamplifier used at least current EEG system subjected to caused by the magnetic field that produced by TMS system.Because the electrode for monitoring EEG is in close proximity to TMS coil usually, magnetic field impulse generates the signal that EEG preamplifier can be caused saturated in one or more electrodes of EEG electrode.After saturated by TMS pulse for the typical preamplifier in EEG system, the relatively long time be spent to recover.
A kind of known method monitoring electroencephalogram EEG during TMS comprises amplifier in EEG system, and it uses sampling hold circuit that amplifier is maintained constant level at TMS impulse duration.It is said, this amplifier can recover in 100 microseconds after TMS end-of-pulsing.Although this system seems to allow to monitor electroencephalogram in short period after TMS reception of impulse, also need the gating that adds and synchronous circuit comes for TMS Systematical control EEG amplifier operation.Additional gating and sample circuit are undesirable, because it needs extra circuit and may be comparatively complicated.
Owing to using metal electrode to sense EEG signal, therefore there is the additional complexity when occurring when monitoring the electroencephalogram of patient during TMS.The maelstrom of being inducted in metal electrode by TMS pulse can cause local heating, and this may cause the calcination of patient's scalp.This point exposes security risk.
U.S. 2002/007128A1 also discloses the another method monitoring electroencephalogram during TMS.The prior art document disclosed between a kind of time sequential routine in TMS system and the time sequential routine of EEG system has synchronous system and method.And the invention provides a kind of control and arrange, it can monitor the signal that EEG system provides during the operation of TMS system, and the operation of stopping TMS system when EEG signal is in undesirably state.
Summary of the invention
According to a first aspect of the invention, provide a kind of system being used for the electroencephalogram (EEG) of monitored patient in TMS (transcranial magnetic stimulation) period, this system comprises:
TMS equipment, it produces multiple magnetic field impulse when being in state of activation, wherein according to TMS therapeutic scheme, described magnetic field impulse can as comprising the train of pulse of the multiple pulses combined or putting on the head of patient as independent pulse;
EEG system, it is for measuring according to being applied to the TMS therapeutic scheme of patient and the EEG data that obtains; With
With the control device of TMS equipment and EEG system communication, described control device is set to activate described EEG system in the time period not producing pulse at described TMS equipment, to make to carry out continuously the measurement of EEG data or to interlock with the magnetic field impulse produced according to described TMS therapeutic scheme and carry out the measurement of EEG data, thus therapeutic effect is monitored and detects the sudden illness that may occur.
In an embodiment, described TMS equipment is set to produce signal when it is not in active state and this signal is sent to described control device, and described control device is correspondingly set to the operation that can trigger described EEG system when described TMS equipment inertia.
In an embodiment, described system comprises the storage device for storing measured EEG data.
In an embodiment, before described TMS equipment applies multiple pulse, described TMS equipment sends preparatory signal to described EEG system, and described preparatory signal is used for trigger recording instrument, described EEG data to be recorded in described storage device by described control device.
In an embodiment, described system comprises sudden illness monitoring module, to detect or to predict the sudden illness of patient.
In an embodiment, when described TMS equipment does not produce pulse, the spectral characteristic of the spontaneity vibration brain activity that described sudden illness monitoring module is measured, to be compared by the profile of obtained measurement result and expection or expectation, thus detects or dopes the sudden illness of patient.
In an embodiment, described sudden illness monitoring module and described control device communicate to connect, so as when detection or when doping sudden illness, described control device can stop the operation of described TMS equipment.
In an embodiment, described sudden illness monitoring module is activated be set to the time period that can not produce pulse at described TMS equipment when coordinating with described EEG system during.
In an embodiment, described system comprises dosage monitoring module, can regulate to make operator the dosage regulating the pulse provided by described TMS equipment in follow-up therapeutic scheme.
In the present embodiment, described TMS equipment is set to apply multiple pulse during waiting the period, described in wait the period and be defined as according to the time period of therapeutic scheme between train of pulse.
In an embodiment, multiple pulse is the independent pulse produced with random interval, and described control device is set to described EEG system of stopping using between the transmission period of these pulses, and immediately activates described EEG system to monitor and to measure reaction.
In an embodiment, apply multiple independent pulse during waiting the period before, described TMS equipment sends preparatory signal via described control device to described EEG system, can activate its protection circuit to make described EEG system.
In an embodiment, described control device is set to automatically regulate the pulse profile produced by described TMS equipment, and/or is recommended in the pulse profile through regulating will produced by described TMS equipment in the successive treatment stage.
In an embodiment, described TMS equipment comprises: generation current and corresponding generate magnetic field providing the capacitor of magnetic field impulse, the high voltage charge circuit that transmits the coil of magnetic field impulse or probe, described capacitor is charged.
In an embodiment, described TMS equipment is set to generate and sends signal to described control device, to show described in time period of not charging to described capacitor at described TMS equipment, when TMS equipment is not in active state.
In an embodiment, described system comprises the navigation system of assisting described TMS equipment location.
In an embodiment, described turnkey draws together patient's consersion unit (being usually embedded in EEG system), thus brings out the stimulation of vision, sensation, audition or other types for follow-up measurement when TMS equipment does not produce pulse.
In an embodiment; described EEG system comprises amplifier and is designed to adapt to the protection circuit of high voltage and the big current be associated with TMS equipment; wherein said control device is set to the forward direction EEG system transfers preparatory signal at TMS magnetic field impulse, to activate described protection circuit.
According to a second aspect of the invention, provide a kind of method at TMS (transcranial magnetic stimulation) period monitored patient electroencephalogram (EEG), described method comprises:
Produce multiple magnetic field impulse, wherein according to TMS therapeutic scheme, described magnetic field impulse is as including the train of pulse of the multiple pulses combined or putting on the head of patient as independent pulse;
Measure the EEG data obtained according to the described TMS therapeutic scheme being applied to patient, wherein in the time period not having magnetic field impulse to produce, described EEG data is measured, with make to measure the step of EEG data be carry out continuously or carry out with the magnetic field impulse produced according to TMS therapeutic scheme is staggered, thus therapeutic effect is monitored and detects potential sudden illness.
In an embodiment, described method comprises: produce a signal when not having magnetic field impulse to produce, and this signal correspondingly can trigger the measurement to EEG data.
In an embodiment, described method comprises the EEG data measured by storage.
In an embodiment, before generation magnetic field impulse, described method comprises generation preparatory signal, and this signal is used for corresponding triggering to the storage of EEG data.
In an embodiment, described method comprises:
When not having magnetic field impulse to produce, measure the spectral characteristic of spontaneous vibration brain activity; And
The profile of obtained measurement and expection or expectation is compared, thus detects or dope the sudden illness of patient.
In an embodiment, described method comprises: when detecting or dope sudden illness, stops producing magnetic field impulse.
In one embodiment, described method comprises:
According to described therapeutic scheme, in the time period produced not having magnetic field impulse, apply multiple independent pulse with random interval; And
Measure the EEG data obtained, thus make operator can adjust the dosage of TMS pulse in follow-up therapeutic scheme.
In the present embodiment, described method comprises:
In the measurement applying with random interval to stop using to EEG data in the process of multiple independent pulse; And
Immediately measure EEG data, to monitor and to measure reaction.
In the present embodiment, described method comprises: automatically regulate the pulse profile through regulating that the profile of described pulse and/or recommendation will produce in follow-up treatment stage.
In an embodiment, described method comprises: according to the therapeutic scheme measured for follow-up EEG data, brings out the stimulation of vision, sensation, audition or other types when not having magnetic field impulse to produce.
Accompanying drawing explanation
With reference to accompanying drawing, the mode below by means of only example makes description to the present invention, wherein:
Fig. 1 shows the high level schematic diagram for the system at TMS (transcranial magnetic stimulation) period monitored patient EEG (electroencephalogram) according to the embodiment of the present invention;
Fig. 2 shows the TMS scheme of the sudden illness for detecting patient according to an aspect of the present invention and the time representation intention of adjacent EEG scheme;
Fig. 3 shows the time representation intention of the TMS scheme for dosage monitoring according to a further aspect in the invention and adjacent EEG scheme;
Fig. 4 shows random TMS pulse in the middle of employing according to another aspect of the invention and is intended to the time representation of the TMS scheme and adjacent EEG scheme of carrying out dosage monitoring; With
Fig. 5 shows and illustrates according to another embodiment of the present invention at the high level flow chart of TMS (transcranial magnetic stimulation) period to the method that patient EEG (electroencephalogram) monitors.
Detailed description of the invention
First referring to figs. 1 through 4, illustrated therein is for the system 10 at TMS (transcranial magnetic stimulation) period monitored patient EEG (electroencephalogram).System 10 comprises the TMS equipment 12 producing multiple magnetic field impulse in ambulatory situations.According to TMS therapeutic scheme, pulse can as including the train of pulse (as shown in the arrow 14 of Fig. 2 to 4) of the multiple pulses combined or being applied on the head 18 of patient as independent pulse (as shown in the arrow 16 in Fig. 4).
In Fig. 2 to 4, according to set safety regulation, activity stimulates (arrow corresponding in Fig. 2 to 4) to combine with the long pause (as shown in arrow 20) between period by TMS therapeutic scheme usually.As scheme know and illustrate, these persistent period of pausing exceed the active persistent period stimulated usually.As will be explained in more detail below like that, the period of waiting defined by pausing can be used to guide the diagnostic data of TMS therapeutic scheme by real-time reading for measuring.The typical treatment regimen being used for the treatment of depression of rTMS is adopted to be made up of the train of pulse (arrow 14 in Fig. 2 to 4) of 40 pulses of transmitting with 10Hz, wherein this train of pulse heel was along with 26 seconds waited the period (arrow 20 in Fig. 2 to 4), so repeatedly until transmitted 3000 pulses.
System 10 also comprises the EEG system 22 of the spontaneous EEG data be associated for the TMS therapeutic scheme measured be applied to patient.As by further describing, the object of EEG system 22 is the brain activities in order to monitored patient, thus extracts diagnostic message during therapeutic scheme.
System 10 also comprises the control device 24 communicated with EEG system 22 with TMS equipment 12.Control device 24 comprises controller 26, thus activates EEG system 22 in the time period (as shown in Fig. 2 to 4 Zhong Kuai district 28) that TMS equipment 12 does not produce pulse.Therefore, EEG data is measured and is carried out continuously or treat to interlock with TMS carrying out, so that monitor treatment effect and detect potential sudden illness.
In an embodiment, TMS equipment 12 is set to produce signal when it is not in active state (that is, corresponding to " non-stimulated " event during therapeutic scheme, the arrow 20 namely in Fig. 2 to 4), and this signal is sent to control device 24.Control device 24 is correspondingly set to the operation triggering EEG system 22 when TMS equipment 12 inertia.
System 10 can comprise storage device 30, to store measured EEG data.In an embodiment, before TMS equipment 12 applies multiple pulse, TMS equipment 12 sends preparatory signal to EEG system 22, and wherein this preparatory signal is used for trigger recording instrument 32 EEG data to be recorded in storage device 30 by control device 24.
In an embodiment, system 10 comprises sudden illness monitoring module 34 (it can be embedded in EEG system 22), to detect or to predict the sudden illness of patient.When TMS equipment 12 does not produce pulse, sudden illness monitoring module 34 can measure the spectral characteristic of spontaneous vibration brain activity, comprises frequency, train of pulse suppresses and pll oscillation, thus compared by the profile of obtained measurement result and expection or expectation.In other words, measured spectral characteristic and individual electroencephalogram attribute (that is, the typical pre-disease activity of patient) mate by this module 34, thus determine the impact of operation on patient of TMS equipment 12.
Sudden illness monitoring module 34 communicates with control device 24, thus when detecting or dope sudden illness, control device 24 can stop the operation of TMS equipment 12.In this application, the POP attribute of EEG system 22 to measured EEG signal quantizes and is recorded in storage device 30, then, the data of this quantification and benchmark electroencephalogram is compared.Under normal circumstances, if pre-disease activity detected, then notify that operator is to determine whether to stop treatment.If detect that sudden illness is movable, then notification operator stops treatment.
In an embodiment, be set to be activated in the time period not producing pulse at TMS equipment 12 with the sudden illness monitoring module 34 of EEG system 22 cooperating, this time period corresponds to the block 20 in Fig. 2 to 4.
In another application, EEG system 10 comprises for amplifying with the moving phase biopotential that associates of brain neuroblastoma unit thus realizing amplifier 36, the protection circuit 38 being designed to adapt to high voltage and the big current be associated with TMS equipment that unipolarity and bipolarity EEG measure and be connected and the control unit 40 of the parts of control EEG system 22.Control device 24 can be set to transmit preparatory signal in the forward direction EEG system 22 producing TMS magnetic field impulse, to activate protection circuit 38, and thus prevent amplifier saturation.
In an embodiment, TMS equipment 12 comprises: generation current the corresponding magnetic field that generates are to provide the capacitor 42 of magnetic field impulse; Transmit coil or the probe 44 of magnetic field impulse; To the high voltage charge circuit 46 that capacitor 42 charges; And control unit 48.With a few second, capacitor 42 is charged, then, the energy stored as single or multiple pulse release in coil 44.
In an embodiment, TMS equipment 12 is set to generate and send signal to control device 24, thus shows in the time period of not charging to capacitor 42 at TMS equipment 12, when TMS equipment is not in active state.This makes EEG system 22 to operate in does not have usually in the environment of so-called " pseudo-illusion ".
Therefore, in use, in the embodiment of as shown in Figures 2 to 4, system 10 starts treatment sequence, such as, be the continued stimulus of 10Hz/4 second and interval between the train of pulse with 26 seconds.In stimulating course, as mentioned above, EEG system 22 is closed to prevent amplifier saturation.After stimulation, send the operation of " non-stimulated " signal to activate EEG system 22 in response to TMS equipment 12 to EEG system 22, this is corresponding to the beginning waiting the period.If TMS capacitor 42 needs charging, then TMS equipment 12 sends preparatory signal to EEG system 22, to prevent from carrying out record in charging process.
Concrete reference diagram 1,2 and 4, in another application, system 10 comprises the dosage monitoring module 50 be usually embedded in EEG system 22, can regulate the pulsed dosage provided by TMS system 12 to make operator in follow-up therapeutic scheme.This dosage monitoring ability can respectively to have come with reference to the one in two kinds of modes of Fig. 3 and Fig. 4.
First, with reference to figure 3, TMS can be applied by traditional approach and treat sequence, the continued stimulus of namely above-mentioned 10Hz/4 second and have be defined as 26 seconds that wait the period train of pulse between interval, wherein typical treatment comprises 75 such sequences.In this application, the dosage monitoring module 50 of EEG system 22 is set to be convenient to rational signal to noise ratio to obtain average electroencephalogram segmentation (EEG epoch), and can perform quantitative monitoring (such as wave spectrum, dependency and connectedness).
Referring to Fig. 4, above-mentioned TMS can be applied and treat sequence, be i.e. the continued stimulus of 10Hz/4 second interval between the train of pulse with 26 seconds.In addition, in this application, be set to during waiting the period 20 can with random interval to apply multiple (as 3-7) pulse 16 separately for TMS equipment 12.As mentioned above, waiting the period 20 was defined as according to the time period of therapeutic scheme between train of pulse 14.
Control device 24 is set to EEG system 22 (as shown in the rectangular block 52 in Fig. 2 to 4) of stopping using between the transmission period of these pulses, and immediately EEG system 22 is activated (as shown in block 28), to monitor and to measure reaction.
As mentioned above, preparatory signal is sent via control device 24 to EEG system 22, with the protection circuit 38 making EEG system 22 can activate it prior to applying multiple independent pulse 16, TMS equipment 12 during waiting the period 20.
In use, after each treatment sequence, characteristic through evoked discharges is quantized, to extract the tolerance to local irritability (as amplitude, time delay, surface characteristic etc.) and overall situation connectedness (as interhemicerebral conduction time, Amplitude Ratio etc.).At the end for the treatment of stage, obtained data are stored in storage device 30, for relatively or trend analysis object.According to the information recorded in treatment stage, operator can adjust dosages when needed.
In an embodiment, control device 24 is set to automatically to regulate the profile of the pulse produced by TMS equipment 12 and/or recommend the profile of the pulse produced by TMS equipment 12 in follow-up treatment stage.
In an embodiment, system 10 comprises the navigation system of the accurate location (such as the location of coil or probe 44) of assisting TMS equipment.
In an embodiment, system 10 comprises the patient's consersion unit 54 be usually embedded in EEG system 22, to bring out the stimulation of vision, sensation, audition or other types.For follow-up measurement, apply this stimulation when TMS equipment 12 does not produce pulse.Again, be usually stored in storage device 30 for the patient's reaction result bringing out stimulation.
Finally, with reference to figure 5, now the method 80 of the EEG of monitored patient during TMS is described.The method comprises the step of the multiple magnetic field impulse of generation as shown in block 82, and this magnetic field impulse can as comprising the train of pulse of the multiple pulses combined or being applied on patients head as independent pulse.This can come according to TMS therapeutic scheme.
As shown in block 84, method 80 also comprises from the step being applied to the EEG data that obtains in the TMS therapeutic scheme of patient and measuring.In the time period produced not having magnetic field impulse, EEG data being measured, the step measuring EEG data being carried out continuously or carries out with the magnetic field impulse produced according to TMS therapeutic scheme is staggered, thus therapeutic effect monitored and detects potential sudden illness.
Therefore, the invention provides a kind of configuration of measuring without illusion realized during formulating the TMS therapeutic scheme among stimulus modelity spontaneous electroencephalogram and the reaction of bringing out property.Embedded or intertexture formula EEG measurement in TMS therapeutic process achieves personalization and the optimization for the treatment of sequence.
It should be understood that disclosed embodiment of this invention is not limited to ad hoc structure disclosed herein, treatment step or material, and the equivalent of these features that those of ordinary skill in the related art understand should be extended to substitute.It is to be further understood that term is only for describing the object of specific embodiment as used herein, and and do not mean that restriction.
Special characteristic, structure or characteristic that " embodiment " mentioned in description or " embodiment " mean to describe in conjunction with the embodiments comprise at least one embodiment of the present invention.Therefore, description various places throughout occur phrase " embodiment " or " embodiment " might not all refer to same embodiment.
Conveniently, multiple project, construction unit, component units and/or material can appear in common list as used herein.But each element that these lists should be interpreted as in this list is identified as member unique separately respectively.Therefore, when not having reverse side to illustrate, in this list, neither one member only can appear in common list the actual equivalent of other member any being just interpreted as same list based on them.In addition, can also come together with reference to various embodiment of the present invention and example together with for the alternative of each element at this.Should be understood that, these embodiments, example and substitute and be not interpreted as equivalent each other, and be considered to representative autonomous separately of the present invention.
In addition, described feature, structure or characteristic can be attached in one or more embodiment in any other suitable manner.In the following description, provide some concrete details, such as length, width, shape etc., to provide the complete understanding to embodiments of the invention.But those skilled in the relevant art will understand, the present invention just can realize without the need to above-mentioned one or more concrete details, or also can adopt the realizations such as other method, assembly, material.In other example, known structure, material or operation are not shown specifically or describe in order to avoid fuzzy various aspects of the present invention.
Although above-mentioned example is for illustration of the principle of the present invention in one or more application, but for a person skilled in the art, when not deviating from principle of the present invention and thought, obviously can in form, the details of usage and enforcement does various amendment and need not creative work be paid.Therefore, the present invention is limited by appending claims.
Claims (24)
1. a method of the electroencephalogram EEG of monitored object during the transcranial magnetic stimulation TMS stage, said method comprising the steps of:
-after the boost pulse from TMS coil, send non-stimulated signal to EEG equipment;
-based on described non-stimulated signal by described EEG device activation;
-measure spontaneous EEG signal from object;
-described spontaneous EEG signal is compared with predetermined EEG template;
Pre-morbidity in-detection comparative result and/or sudden illness activity.
2. method according to claim 1, further comprising the steps of:
-before any boost pulse from TMS coil, measure the spontaneous EEG signal from object;
-based on stimulating measured EEG signal in advance, generate the predetermined EEG template for object; And
-wherein, the comparison of the EEG signal that the described predetermined EEG template of generation records after being used for boost pulse.
3. method according to claim 1 and 2, wherein, described predetermined EEG template comprises known pre-disease activity.
4. the method according to any one of claim 1-3, further comprising the steps of:
-before the described TMS coil of activation, send stimulus signal to described EEG equipment; And
-based on described stimulus signal stop using described EEG equipment.
5. the method according to any one of claim 1-4, further comprising the steps of:
-after the capacitor of TMS equipment or Capacitor banks that are connected to described TMS coil complete charging after boost pulse, send non-stimulated signal.
6. the method according to any one of claim 1-4, further comprising the steps of:
-after sending non-stimulated signal to described EEG equipment, send to described EEG equipment and show that the one or more capacitors be connected in the TMS equipment of TMS coil are charging or completing the additional signal of charging after boost pulse; And
-at least based on described non-stimulated signal and additional signal, activate described EEG equipment.
7. the method according to any one of claim 1-6, further comprising the steps of:
-notify the user of described TMS coil: occur and/or do not occur pre-disease activity after testing.
8. the method according to any one of claim 1-7, further comprising the steps of:
If-define pre-morbidity and/or sudden illness activity, then send stop signal to the TMS coil apparatus being connected to described TMS coil, and
-stop the TMS from described TMS coil to stimulate based on described stop signal.
9. according to the method in claim 1-8 described in any one of `, further comprising the steps of:
-before TMS boost pulse, send stimulus signal to described EEG equipment, and
-in EEG equipment, activate compensation mechanism, to prevent EEG saturated.
10. method according to claim 9, wherein, described compensation mechanism is gating operation.
11. 1 kinds of methods monitored the transcranial magnetic stimulation TMS dosage accumulated in subject, said method comprising the steps of:
-wait in the period after the predetermined sequence through TMS boost pulse, send preparatory signal to EEG equipment;
-based on described preparatory signal, start recording through bringing out EEG reaction and being averaging object;
-before follow-up predetermined TMS stimulating pulsatile series, send stop signal to described EEG equipment;
-based on described stop signal, stop to object through bring out EEG reaction record and be averaging;
-based on described wait the period during record and equalization through evoked discharges, determine local excitation and/or the overall situation connective;
-store the described local excitation through determining that waits the period for described and/or the overall situation connective,
-wait the local excitation through determining that the period stores and/or the connective local excitation with waiting the period for last of the overall situation and/or overall connectedness compare for described;
-based on described comparison, if determine to make adjustment, then for TMS stimulate subsequent sequence and to TMS stimulate predetermined sequence regulate.
12. methods according to claim 11, wherein, based on described preparatory signal, described EEG opens compensation mechanism, to prevent EEG saturated.
13. methods according to claim 12, wherein, described compensation mechanism is gating operation.
14. methods according to any one of claim 11-13, wherein, the described local excitation through determining comprises local amplitude, time delay, surface characteristic or their combination.
15. methods according to any one of claim 11-14, wherein, the described overall situation connectedness through determining comprise amplitude between overall ON time, electrode, delay relatively or its combination.
16. methods according to any one of claim 11-15, further comprising the steps of:
-multiple wait the period after, determine to measure local irritability and/or the connective extraction of the overall situation; And
-measure based on determined local excitation and/or the connective extraction of the overall situation, the subsequent sequence stimulated for TMS or subsequent sequence group and adjustment is made to the predetermined sequence that TMS stimulates.
17. methods according to claim 16, wherein, the extraction measurement of determined local excitation comprise amplitude, time delay, signal power, based on the area of curve characteristic or their combination.
18. methods according to claim 16 or 17, wherein, determined overall connectedness comprises interhemicerebral ON time and/or Amplitude Ratio.
19. methods according to any one of claim 11-18, wherein, the adjustment done by the subsequent sequence that TMS is stimulated comprise regulate boost pulse intensity, the persistent period, frequency and/or number or their combination.
20. methods according to any one of claim 11-19, be also included in each wait the period during to be stimulated the step of object at least one times by TMS coil.
21. methods according to claim 20, be also included in each wait the period during be less than 20 times object stimulated, be preferably less than 10 times, but be more preferably between 3-7 time.
22. 1 kinds of temporary or non-transitory computer-readable medium, have one group of computer-readable instruction for performing the method according to any one of claim 1-21 stored thereon.
23. 1 kinds of systems, comprising:
-transcranial magnetic stimulation TMS coil apparatus;
-electroencephalogram EEG equipment, it has at least one compensation mechanism for preventing EEG saturated in the stimulating course from TMS coil apparatus;
-TMS equipment, it has the processor carrying out electronic communication with non-transitory computer-readable medium, and capacitor, wherein said TMS equipment connection to described TMS coil and with described EEG devices communicating.
24. methods according to claim 23, wherein, described non-transitory computer-readable medium has one group of computer-readable instruction for performing the method according to any one of claim 1-21 stored thereon.
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| FI20135436 | 2013-04-26 | ||
| FI20135436A FI125325B (en) | 2013-04-26 | 2013-04-26 | Method and system for evaluating TMS dose and detecting seizure |
| PCT/FI2014/050198 WO2014140432A1 (en) | 2013-03-15 | 2014-03-17 | Method and system for tms dose assessment and seizure detection |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109864750A (en) * | 2019-01-31 | 2019-06-11 | 华南理工大学 | Based on the state of mind assessment and regulating system and its working method stimulated through cranium |
| CN112218681A (en) * | 2018-05-01 | 2021-01-12 | 布雷恩斯维公司 | Apparatus and method for real-time closed-loop brain stimulation |
| CN114610112A (en) * | 2022-01-25 | 2022-06-10 | 湖南华医电磁医学研究院有限公司 | Magnetic shock therapeutic instrument |
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| DE102015114483A1 (en) | 2015-08-31 | 2017-03-02 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Coil arrangement and system for transcranial magnetic stimulation |
| US12042293B2 (en) | 2016-09-27 | 2024-07-23 | Mor Research Applications Ltd. | EEG microstates analysis |
| US11198018B2 (en) | 2016-09-27 | 2021-12-14 | Mor Research Applications Ltd. | EEG microstates for controlling neurological treatment |
| WO2018078619A1 (en) * | 2016-10-25 | 2018-05-03 | Brainsway Ltd | Apparatus and methods for predicting therapy outcome |
| FI20165933L (en) * | 2016-12-07 | 2018-06-08 | Mega Elektroniikka Oy | Interface unit and method for controlling stimulation system |
| WO2021222124A1 (en) * | 2020-04-27 | 2021-11-04 | Cadence Neuroscience, Inc. | Therapy systems with quantified biomarker targeting, including for epilepsy treatment, and associated systems and methods |
| CN113545792B (en) * | 2021-07-20 | 2024-06-18 | 深圳市人民医院 | Detection method of nerve biomarker based on TMS-EEG |
| KR20230127894A (en) | 2022-02-25 | 2023-09-01 | 재단법인 아산사회복지재단 | Method and device for creating noninvasive dynamic tractography precision neuroimaging |
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- 2014-03-17 KR KR1020147034610A patent/KR20150023364A/en not_active Application Discontinuation
- 2014-03-17 JP JP2015519269A patent/JP2015521517A/en not_active Ceased
- 2014-03-17 RU RU2014147238A patent/RU2014147238A/en not_active Application Discontinuation
- 2014-03-17 EP EP14716617.7A patent/EP2968966A1/en not_active Withdrawn
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| US20020007128A1 (en) * | 1998-04-27 | 2002-01-17 | Ives John R. | Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation |
| US20070142874A1 (en) * | 2005-01-21 | 2007-06-21 | John Michael S | Multiple-symptom medical treatment with roving-based neurostimulation. |
| WO2008070001A2 (en) * | 2006-12-01 | 2008-06-12 | Beth Israel Deaconess Medical Center, Inc. | Transcranial magnetic stimulation (tms) methods and apparatus |
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Also Published As
| Publication number | Publication date |
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| JP2015521517A (en) | 2015-07-30 |
| RU2014147238A (en) | 2016-06-10 |
| KR20150023364A (en) | 2015-03-05 |
| EP2968966A1 (en) | 2016-01-20 |
| WO2014140432A1 (en) | 2014-09-18 |
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