CN104383188A - 用于防治仔猪水肿病的药物组合物及其制备方法 - Google Patents
用于防治仔猪水肿病的药物组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于防治仔猪水肿病的药物组合物及其制备方法,其中药物组合物包括以下原料药材:栀子、八角莲、蒲公英、千金藤、石蝉草、板蓝根、地丁、芒种花、水葱、过塘蛇、钓鱼竿、水葫芦根、杏仁和地骷髅。本发明的有益效果是:本发明的药物组合物以清热解毒、利水消肿、宣肺利水为主,以健脾化湿、温肾、安神定志为辅,防治仔猪水肿病具有防治效果好、见效快、疗效确切、不产生抗药性、不易复发、副作用少、药物残留量低等优势。
Description
技术领域
本发明涉及兽药领域,尤其涉及一种用于防治仔猪水肿病的药物组合物及其制备方法。
背景技术
猪水肿病又称大肠杆菌毒血症、浮肿病、胃水肿,是小猪一种急性、致死性的疾病,其特征为胃壁和其它某些部位发生水肿。本病主要发生于断乳仔猪,小至数日龄,大至4月龄都有发生。生长快、体况健壮的仔猪最为常见,瘦小仔猪少发生。带菌母猪传播给仔猪,呈地方性流行,常限于某些猪场和某些窝的仔猪。饲料饲养方法改变,饲料单一,气候变化,被污染后的水,环境,用具等均可导致本病的发生机会增加。
主要临床症状有:病猪突然发病,精神沉郁,食欲减少,口流白沫,体温无明显变化,病前1-2天有轻度腹泻,后便秘。心跳疾速,呼吸初快而浅,后来慢而深。喜卧地、肌肉震颤,不时抽搐,四肢动作游泳状,呻吟,站立时拱腰,发抖。前肢如发生麻痹,则站立不稳,后肢麻痹,则不能站立。行走时四肢无力,共济失调,步态摇摆不稳,盲目前进或作圆圈运动。水肿是本病的特殊症状,常见于脸部、眼睑、结膜、齿龈、颈部、腹部的皮下。有的病猪没有水肿的变化。主要表现是突然发病,体温不高,四肢运动障碍,后躯无力,摇摆和共济失调;有的病猪作圆圈运动或盲目乱冲,突然猛身前跃;各种刺激或捕捉时,触之惊叫,叫声嘶哑,倒地,四肢乱动,似游泳状;病猪常见脸部、眼睑水肿,重者延至颜面、颈部,头部变胖。
特征性的病变是胃壁,结肠肠系膜,眼睑和脸部及颌下淋巴结水肿。胃内充满食物,粘膜潮红,有时出血,胃底区粘膜下有厚层的透明水肿,有带血的胶冻样水肿浸润,使粘膜与肌层分离,水肿严重的可达2-3厘米,严重的可波及贲门区和幽门区。大肠系膜、胆囊、喉头、直肠周围也常有水肿,淋巴结水肿、充血、出血、心包和胸腹腔有较多积液,暴露空气则凝成胶冻状。肾包膜水肿,膀胱粘膜轻度出血,出血性肠炎变化常见。
目前治疗仔猪水肿病的药物多为西药如硫酸卡那霉素,虽然具有一定的治疗效果,但是效果不明显,而且不能起到预防的作用,且抗生素类药物存在药物残留等问题。
发明内容
本发明所要解决的技术问题在于提供一种用于防治仔猪水肿病的药物组合物及其制备方法,本发明的药物组合物以清热解毒、利水消肿、宣肺利水为主,以健脾化湿、温肾、安神定志为辅,防治仔猪水肿病具有防治效果好、见效快、疗效确切、不产生抗药性、不易复发、副作用少、药物残留量低等优势。
为了实现上述发明目的,本发明提供了一种用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物包括以下原料药材:栀子、八角莲、蒲公英、千金藤、石蝉草、板蓝根、地丁、芒种花、水葱、过塘蛇、钓鱼竿、水葫芦根、杏仁和地骷髅。
所述药物组合物中各原料药材的重量份数为:栀子20-30重量份、八角莲12-21重量份、蒲公英15-30重量份、千金藤10-19重量份、石蝉草8-15重量份、板蓝根10-20重量份、地丁5-15重量份、芒种花8-17重量份、水葱9-21重量份、过塘蛇8-20重量份、钓鱼竿5-15重量份、水葫芦根10-20重量份、杏仁10-20重量份和地骷髅10-15重量份。
所述药物组合物中各原料药材的重量份数可以优选为:栀子23-28重量份、八角莲16-19重量份、蒲公英18-24重量份、千金藤12-17重量份、石蝉草11-14重量份、板蓝根13-18重量份、地丁8-12重量份、芒种花11-16重量份、水葱12-18重量份、过塘蛇13-18重量份、钓鱼竿7-13重量份、水葫芦根12-17重量份、杏仁15-20重量份和地骷髅12-15重量份。
所述药物组合物中各原料药材的重量份数还可以优选为:栀子26重量份、八角莲17重量份、蒲公英21重量份、千金藤15重量份、石蝉草12重量份、板蓝根15重量份、地丁10重量份、芒种花14重量份、水葱15重量份、过塘蛇15重量份、钓鱼竿10重量份、水葫芦根14重量份、杏仁17重量份和地骷髅13重量份。
所述药物组合物还包括茯苓、白术、五指毛桃、乳花、紫河车、丹参、胆南星和太阳针。
所述药物组合物中各原料药材的重量份数还可以优选为:栀子20-30重量份、八角莲12-21重量份、蒲公英15-30重量份、千金藤10-19重量份、石蝉草8-15重量份、板蓝根10-20重量份、地丁5-15重量份、芒种花8-17重量份、水葱9-21重量份、过塘蛇8-20重量份、钓鱼竿5-15重量份、水葫芦根10-20重量份、杏仁10-20重量份、地骷髅10-15重量份、茯苓10-25重量份、白术10-15重量份、五指毛桃10-20重量份、乳花10-20重量份、紫河车10-15重量份、丹参10-22重量份、胆南星10-15重量份和太阳针10-20重量份。
所述药物组合物中各原料药材的重量份数又可以优选为:栀子26重量份、八角莲17重量份、蒲公英21重量份、千金藤15重量份、石蝉草12重量份、板蓝根15重量份、地丁10重量份、芒种花14重量份、水葱15重量份、过塘蛇15重量份、钓鱼竿10重量份、水葫芦根14重量份、杏仁17重量份、地骷髅13重量份、茯苓18重量份、白术12重量份、五指毛桃15重量份、乳花15重量份、紫河车12重量份、丹参16重量份、胆南星13重量份和太阳针15重量份。
为了更好的实现上述发明目的,本发明提供了一种用于防治仔猪水肿病的药物组合物,所述药物组合物的剂型为散剂,其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉;
第三步,在将第二步获得的超微细粉中加入相对于其质量2~4倍的淀粉,混合,获得散剂。
所述药物组合物的剂型为注射剂,其制备方法为:
第一步,将所述原料药材按比例混合,放入超微粉碎机中粉碎成0.1~10μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率至少为95%;
第二步,在第一步获得的混合粉料中加入相对于所述混合粉料的质量3~5倍的醇浓度为85%~95%的乙醇,搅拌溶解获得乙醇溶液,将乙醇溶液在5℃~10℃的条件下静置24~36小时,采用渗漉法以每分钟1~2ml的速度缓缓渗漉,收集渗漉液,浓缩并干燥,并在此放入超微粉碎机中粉碎40~60分钟,获得0.1~10μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率至少为95%;
第三步,取第二步获得的混合粉料10g~20g,加入丙二醇30g~50g,加200ml注射用水,搅拌使其溶解,进一步加注射用水至1000ml,再加入1g~1.5g针用活性炭,充分搅拌30~50分钟;脱炭过滤;用0.22~0.24μm微孔滤膜过滤;冷冻干燥得无菌粉末,分装灌封。
本发明的有益效果是:本发明的药物组合物以清热解毒、利水消肿、宣肺利水为主,以健脾化湿、温肾、安神定志为辅,防治仔猪水肿病具有防治效果好、见效快、疗效确切、不产生抗药性、不易复发、副作用少、药物残留量低等优势。
具体实施方式
中兽医学认为本病是由于体内水液潴留,泛滥肌肤,引起以头面、眼睑、四肢,甚至全身浮肿等为临床特征的疾病。本病有风邪袭表、疮毒内犯、外感水湿、饮食不节及禀赋不足、久病劳倦,形成本病的机理为肺失通调,脾失转输,肾失开阖,三焦气化不利。本病在《内经》中称为“水”,并根据不同症状分为风水、石水、涌水。《灵枢,水胀》篇对其症状作了详细的描述,如“水始起也,目窠上微肿,如新卧起之状,其颈脉动,时咳,阴股间寒,足胫肿,腹乃大,其水已成矣。以手按其腹,随手而起,如裹水之状,此其候也。”至其发病原因,《素问·水热穴论篇》指出:“故其本在肾,其末在肺。”《素问·至真要大论篇》又指出:“诸湿肿满,皆属于脾。”可见在《内经》时代,对水肿病已有了较明确的认识。《金匮要略》称本病为“水气”,按病因、病证分为风水、皮水、正水、石水、黄汗五类。又根据五脏证候分为心水、肺水、肝水、脾水、肾水。至元代《丹溪心法·水肿》才将水肿分为阴水和阳水两大类,指出:“若遍身肿,烦渴,小便赤涩,大便闭,此属阳水;“若遍身肿,不烦渴,大便溏,小便少,不涩赤,此属阴水”。这一分类方法至今对指导临床辨证仍有重要意义。明代《医学入门·杂病分类·水肿》提出疮痍可以引起水肿,并记载了“脓疮搽药,愈后发肿”的现象,清代《证治汇补·水肿》归纳总结了前贤关于水肿的治法,认为治水肿之大法,“宜调中健脾,脾气实,自能升降运行,则水湿自除,此治其本也。”
根据上述理论,本发明提供了一种用于防治仔猪水肿病的药物组合物,包括以下原料药材:栀子、八角莲、蒲公英、千金藤、石蝉草、板蓝根、地丁、芒种花、水葱、过塘蛇、钓鱼竿、水葫芦根、杏仁和地骷髅;其中,栀子、八角莲、千金藤、蒲公英、芒种花清热解毒、利水消肿,为君药,石蝉草、板蓝根、地丁清热解毒,水葱、过塘蛇、钓鱼竿利水消肿,在此方中同为臣药,水葫芦根、杏仁、地骷髅宣肺利水。此外,水液代谢关系最为密切的脏腑是肺、脾、肾,这三个脏器的功能失调是引起水肿发生的关键所在,因此优选地,本发明的方中还包括茯苓、白术、五指毛桃、乳花、紫河车、丹参、胆南星和太阳针,茯苓、白术、五指毛桃健脾化湿,乳花、紫河车、丹参温肾,胆南星、太阳针安神定志。全方有机结合,相辅相成,共奏清热解毒、利水消肿之效。
其中,上述原料药材的药理如下:
栀子:苦,寒。归心、肺、三焦经。功能主治:果实:泻火除烦,清热利尿,凉血解毒。用于热病心烦,黄疸尿赤,血淋涩痛,血热吐衄,目赤肿痛,火毒疮疡;外治扭挫伤痛。根:泻火解毒,清热利湿,凉血散瘀。用于传染性肝炎,跌打损伤,风火牙痛。
八角莲: 甘、味苦,凉。功能主治:清热解毒,活血化瘀。主治:毒蛇咬伤,跌打损伤;外用治虫蛇咬伤,痈疮疖肿,淋巴结炎,腮腺炎,乳腺癌。
蒲公英:苦、甘,寒。归肝、胃经。功能主治:清热解毒,消肿散结,利尿通淋。用于疔疮肿毒,乳痈,瘰疠,目赤,咽痛,肺痈,肠痈,湿热黄疸,热淋涩痛。
千金藤:苦、辛,寒。功能主治:清热解毒,利尿消肿,祛风止痛。用于咽喉肿痛,牙痛,胃痛,水肿,脚气,尿急尿痛,小便不利,外阴湿疹,风湿关节痛;外用治跌打损伤,毒蛇咬伤,痈肿疮疖。
石蝉草:辛;凉。归肺;脾;肝;肾经。功能主治:清热解毒;化瘀散结;利水消肿。主肺热咳喘;麻疹;疮毒;癌肿;烧烫伤;跌打损伤;肾炎水肿。
板蓝根:苦,寒。归心、胃经。功能主治:清热解毒,凉血利咽。用于温毒发斑,舌绛紫暗,痄腮,喉痹,烂喉丹痧,大头瘟疫,丹毒,痈肿。
地丁:别名:箭头草(《普济方》),羊角子(《乾坤生意秘韫》),独行虎(《纲目》),地丁草(《本草再新》),如意草(《随息居饮食谱》)。来源:为堇菜科植物紫花地丁、犁头草;豆科植物米口袋、小米口袋或龙胆科植物华南龙胆的带根全草。①紫花地丁、犁头草:5~8月间,果实成熟时采取带根全草,去净泥土,晒干。②米口袋及小米口袋:春、秋季采挖带根全草,晒干或鲜用。③华南龙胆:春、夏季,花初开时采取全草,晒干。苦,寒。入心、肝经。功能主治:清热利湿,解毒消肿。治疔疮,痈肿,瘰疬,黄疸,痢疾,腹泻,目赤,喉痹,毒蛇咬伤。
芒种花:微苦,寒。功能主治:清热解毒,凉血止血,杀虫,止痒。全草:上呼吸道感染,肝炎,痢疾,肾炎。果:血崩,鼻衄。叶:外用治皮肤瘙痒,黄水疮。根:驱蛔虫。
水葱:味甘;淡;性平。归膀胱经。功能主治:利水消肿。主水肿胀满;小便不利。
过塘蛇:味苦;微甘;性寒,功能主治:清热;利尿;解毒。主感冒发热;燥热咳嗽;高热烦渴;淋痛;水肿;咽痛;喉肿;口疮;风火牙痛;疮痈疔肿;烫火伤;跌打伤肿;毒蛇;狂犬咬伤。
钓鱼竿:微苦,凉。功能主治:清热解毒,利水消肿,散瘀止痛。用于肺热咳嗽,肝炎,水肿;外用治跌打损伤,毒蛇咬伤,烧烫伤。
水葫芦根:别名:土冬花。来源:药材基源:为菊科植物和尚菜的根及根茎。拉丁植物动物矿物名:Adenocaulon himalaicum Edgew. [A.adhaerescens Maxim.; A.bicolor Hook.var .adhaerescens Maki-no]采收和储藏:夏、秋季采挖,洗净鲜用或晒干。味辛;苦;性平。功能主治:宣肺平喘;利水消肿;散瘀痛。主咳嗽气喘;水肿小便不利;产后瘀滞腹痛;跌打损伤。
杏仁: 苦;温;有毒。归肺;脾;大肠经。功能主治:祛痰止咳;平喘;润肠;下气开痹。主外感咳嗽;喘满;伤燥咳嗽;寒气奔豚;惊痫;胸痹;食滞脘痛;血崩;耳聋;疳肿胀;湿热淋证;疥疮;喉痹;肠燥便秘。
地骷髅: 甘;辛;平。归肺;肾经。功能主治:行气消积,化痰,解渴,利水肖肿。主咳嗽痰多;食积气滞;腹胀痞满;痢疾;消渴;脚气,水肿。
茯苓:甘、淡,平。归心、肺、脾、肾经。功能主治:利水渗湿,健脾宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
白术:苦、甘,温。归脾、胃经。功能主治:健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。土白术健脾,和胃,安胎。用于脾虚食少,泄泻便溏,胎动不安。
五指毛桃:甘,微温。功能主治:健脾化湿,行气化痰,舒筋活络。用于肺结核咳嗽,慢性支气管炎,风湿性关节炎,腰腿疼,脾虚浮肿,病后盗汗,白带。
乳花:别名:石花;来源:药材基源:为钟乳液滴石上散溅如花者。拉丁植物动物矿物名:Stakactite。采收和储藏:石灰岩山洞中采集,除去杂石,洗净。甘;温;无毒。功能主治:温肾;壮骨;助阳。主筋骨痿软;腰脚冷痛;阳痿早泄。
紫河车:甘、咸,温。归心、肺、肾经。功能主治:温肾补精,益气养血。用于虚劳羸瘦,骨蒸盗汗,咳嗽气喘,食少气短,阳痿遗精,不孕少乳。
丹参: 苦,微寒。归心、肝经。功能主治:祛瘀止痛,活血通经,清心除烦。用于月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠;肝脾肿大,心绞痛。
胆南星: 苦、微辛,凉。归肺、肝、脾经。功能主治:清热化痰,息风定惊。用于痰热咳嗽,咯痰黄稠,中风痰迷,癫狂惊痫。
太阳针: 来源:珠藓科平珠藓属植物平珠藓Plagiopus oederi (Gunn.)Limpr.,以全草入药。四季可采,挤出水后阴干。淡,平。功能主治:镇静安惊。用于失眠心慌,癫痫。
以下采用实施例来详细说明本发明的实施方式,借此对本发明如何应用技术手段来解决技术问题,并达成技术效果的实现过程能充分理解并据以实施。
实施例1 散剂
本发明实施例提供了一种用于防治仔猪水肿病的药物组合物,由以下重量份数的原料药材制成:栀子26重量份、八角莲17重量份、蒲公英21重量份、千金藤15重量份、石蝉草12重量份、板蓝根15重量份、地丁10重量份、芒种花14重量份、水葱15重量份、过塘蛇15重量份、钓鱼竿10重量份、水葫芦根14重量份、杏仁17重量份、地骷髅13重量份、茯苓18重量份、白术12重量份、五指毛桃15重量份、乳花15重量份、紫河车12重量份、丹参16重量份、胆南星13重量份和太阳针15重量份;
其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量3倍的醇浓度为90%的乙醇,加热回流2小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量2倍的醇浓度为90%的乙醇,加热回流2小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎2小时,粉碎,过筛,获得300目目的超微细粉;
第三步,在将第二步获得的超微细粉中加入相对于其质量3倍的淀粉,混合,获得散剂。
实施例2注射剂
本发明实施例提供了一种用于防治仔猪水肿病的药物组合物,由以下重量份数的原料药材制成:栀子26重量份、八角莲17重量份、蒲公英21重量份、千金藤15重量份、石蝉草12重量份、板蓝根15重量份、地丁10重量份、芒种花14重量份、水葱15重量份、过塘蛇15重量份、钓鱼竿10重量份、水葫芦根14重量份、杏仁17重量份和地骷髅13重量份;
其制备方法为:
第一步,将所述原料药材按比例混合,放入超微粉碎机中粉碎成0.1~10μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率至少为95%;
第二步,在第一步获得的混合粉料中加入相对于所述混合粉料的质量4倍的醇浓度为90%的乙醇,搅拌溶解获得乙醇溶液,将乙醇溶液在8℃的条件下静置30小时,采用渗漉法以每分钟2ml的速度缓缓渗漉,收集渗漉液,浓缩并干燥,并在此放入超微粉碎机中粉碎50分钟,获得0.1~10μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率至少为95%;
第三步,取第二步获得的混合粉料15g,加入丙二醇40g,加200ml注射用水,搅拌使其溶解,进一步加注射用水至1000ml,再加入1g针用活性炭,充分搅拌40分钟;脱炭过滤;用0.23μm微孔滤膜过滤;冷冻干燥得无菌粉末,分装灌封。
毒性试验
将栀子26g、八角莲17 g、蒲公英21 g、千金藤15 g、石蝉草12 g、板蓝根15 g、地丁10 g、芒种花14 g、水葱15 g、过塘蛇15 g、钓鱼竿10 g、水葫芦根14 g、杏仁17 g、地骷髅13 g、茯苓18g、白术12g、五指毛桃15g、乳花15g、紫河车12g、丹参16g、胆南星13g和太阳针15g混合,粉碎成200目的粉末,加入1962g的水,浸泡30分钟后,在100℃的温度下煎煮1小时,煎煮液过滤,获得第一过滤液和滤渣,将获得的滤渣加入1300g的水,在100℃的温度下,煎煮50分钟,煎煮液过滤,获得第二过滤液,将第一过滤液和第二过滤液合并,获得煎煮液1。
选用SD大鼠60只,分三组,每组20只,给予不同浓度(18.0、6.0、2.0g生药/kg)的本发明的中药组合物的煎液1,每天灌胃一次,连续90天,末次给药后24小时各组活杀1/2动 物(雌雄各半),其余1/2动物继续观察2周后活杀。试验期间观察动物的外观、一般行为、摄食量、体重变化,给药后90天和停药2周进行血液学(RBC、 HB、网织红细胞、PLT、CT、WBC及分类)和血液生化(AST、ALT、ALP、 Glu、BUN、Crca、TP、T.BIL、ALB、CHOL)、尿液生化、脏器系数、病理 组织学等指标检查。试验结果表明:本发明的中药制剂在高、中、低剂量组动物一般状态良好,外观体征、行为活动、进食量和体重增长均无异常变化;三个剂量组及对照组血液学检查、血液生化学、尿液生化检查均在正常范围,组间无显著差异;各组主要脏器组织病理学检查未见明显异常。上述指标停药2周后也未见改变。本试验用药剂量分别为临床用药剂量的180、60、20倍,根据试验结果本发明的中药制剂在高、中、低三个剂量(18.0、6.0、2.0g生药/kg)连续90天给药对大鼠无明显影响,无明确的毒性靶器官和敏感指标,恢复期观察也未见延迟性毒性反应,提示本发明的中药制剂临床应用的剂量安全性较高。
对比试验
山东青岛市某猪养殖场,2013年底发现500多头断奶仔猪均出现不同程度的水肿,主要以头部水肿为主,还出现运动失调、惊厥、麻痹、后躯无力等症状,发现患病几天后出现死亡仔猪,将死亡仔猪解剖后,发现头部皮下呈灰白色凉粉样水肿,在胃的粘膜层和肌肉层间呈胶冻样水肿,肠粘膜红肿甚至出血。
在无菌环境下,分离出死亡仔猪胃部水肿液及胃淋巴结于麦康凯琼脂平板上划线接种,37℃条件下培养24h,挑选红色中等大小光滑菌落,接种于普通肉汤增菌,再划线于麦康凯琼脂平板上,挑取单个菌落,经涂片、染色、镜检,证实为革兰氏阴性杆菌。将纯种菌株接种于普通营养肉汤,置于37℃培养18h,菌液先用比浊法粗略计数,然后倍比稀释,以平板表面涂布法计数菌落总数,然后将菌液稀释备用。
选择健康仔猪60头作为预防实验对象,断奶后随即分成两组,每组20头,分别为实施例组、对照组和空白对照组,实施例组断奶后饲喂混有本发明实施例1散剂的传统饲料,对照组和空白对照组按照传统方式饲喂传统饲料,三天后进行人工感染,将备用的菌液注射实施例组和对照组的健康仔猪,将无菌肉汤注射空白对照组,感染后三个实验组均饲喂传统饲料,观察各实验组发病情况,结果如表1所示。
表1 各实验组发病情况对照表
从表1的数据可知,本发明实施例1的散剂饲喂的仔猪,其发病率明显降低,即本发明的药物组合物具有预防仔猪水肿病的作用,且无毒副作用,效果显著。
选择其中确诊患病的仔猪300头作为治疗实验对象,随机分成三个实验组,每组100头,分别为实施例组1、实施例组2和对照组,各实验组仔猪日龄、体重、病情等均无统计学差异,具有可比性。三个实验组分别采用实施例1的散剂、实施例2的注射剂和传统药物进行治疗;其中,散剂按照3:100的重量份数比混入传统饲料中,按照传统饲喂方式喂养,连续喂养3-7天;实施例2的注射剂每次肌注5ml,每日一次,连续治疗3-7天;对照组采用肌注硫酸卡那霉素注射液,每头30万IU,注射液2ml,每日一次,连用3-4次。治疗结果如表2所示。
表2 各实验组治疗结果对照表
从表2的数据可知,采用本发明实施例1-2的药物组合物对仔猪水肿病治愈率明显高于对照组。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (9)
1.用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物包括以下原料药材:栀子、八角莲、蒲公英、千金藤、石蝉草、板蓝根、地丁、芒种花、水葱、过塘蛇、钓鱼竿、水葫芦根、杏仁和地骷髅。
2.根据权利要求1所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物中各原料药材的重量份数为:栀子20-30重量份、八角莲12-21重量份、蒲公英15-30重量份、千金藤10-19重量份、石蝉草8-15重量份、板蓝根10-20重量份、地丁5-15重量份、芒种花8-17重量份、水葱9-21重量份、过塘蛇8-20重量份、钓鱼竿5-15重量份、水葫芦根10-20重量份、杏仁10-20重量份和地骷髅10-15重量份。
3.根据权利要求1或2所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物中各原料药材的重量份数为:栀子23-28重量份、八角莲16-19重量份、蒲公英18-24重量份、千金藤12-17重量份、石蝉草11-14重量份、板蓝根13-18重量份、地丁8-12重量份、芒种花11-16重量份、水葱12-18重量份、过塘蛇13-18重量份、钓鱼竿7-13重量份、水葫芦根12-17重量份、杏仁15-20重量份和地骷髅12-15重量份。
4.根据权利要求1-3任一项所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物中各原料药材的重量份数为:栀子26重量份、八角莲17重量份、蒲公英21重量份、千金藤15重量份、石蝉草12重量份、板蓝根15重量份、地丁10重量份、芒种花14重量份、水葱15重量份、过塘蛇15重量份、钓鱼竿10重量份、水葫芦根14重量份、杏仁17重量份和地骷髅13重量份。
5.根据权利要求1-4任一项所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物还包括茯苓、白术、五指毛桃、乳花、紫河车、丹参、胆南星和太阳针。
6.根据权利要求1-5任一项所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物中各原料药材的重量份数为:栀子20-30重量份、八角莲12-21重量份、蒲公英15-30重量份、千金藤10-19重量份、石蝉草8-15重量份、板蓝根10-20重量份、地丁5-15重量份、芒种花8-17重量份、水葱9-21重量份、过塘蛇8-20重量份、钓鱼竿5-15重量份、水葫芦根10-20重量份、杏仁10-20重量份、地骷髅10-15重量份、茯苓10-25重量份、白术10-15重量份、五指毛桃10-20重量份、乳花10-20重量份、紫河车10-15重量份、丹参10-22重量份、胆南星10-15重量份和太阳针10-20重量份。
7.根据权利要求1-6任一项所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物中各原料药材的重量份数为:栀子26重量份、八角莲17重量份、蒲公英21重量份、千金藤15重量份、石蝉草12重量份、板蓝根15重量份、地丁10重量份、芒种花14重量份、水葱15重量份、过塘蛇15重量份、钓鱼竿10重量份、水葫芦根14重量份、杏仁17重量份、地骷髅13重量份、茯苓18重量份、白术12重量份、五指毛桃15重量份、乳花15重量份、紫河车12重量份、丹参16重量份、胆南星13重量份和太阳针15重量份。
8.根据权利要求1-7任一项所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物的剂型为散剂,其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉;
第三步,在将第二步获得的超微细粉中加入相对于其质量2~4倍的淀粉,混合,获得散剂。
9.根据权利要求1-7任一项所述的用于防治仔猪水肿病的药物组合物,其特征在于,所述药物组合物的剂型为注射剂,其制备方法为:
第一步,将所述原料药材按比例混合,放入超微粉碎机中粉碎成0.1~10μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率至少为95%;
第二步,在第一步获得的混合粉料中加入相对于所述混合粉料的质量3~5倍的醇浓度为85%~95%的乙醇,搅拌溶解获得乙醇溶液,将乙醇溶液在5℃~10℃的条件下静置24~36小时,采用渗漉法以每分钟1~2ml的速度缓缓渗漉,收集渗漉液,浓缩并干燥,并在此放入超微粉碎机中粉碎40~60分钟,获得0.1~10μm体积平均粒径的微米级颗粒和粒径小于0.1μm体积平均粒径的纳米级颗粒组成的混合粉料,所述混合粉料的得粉率至少为95%;
第三步,取第二步获得的混合粉料10g~20g,加入丙二醇30g~50g,加200ml注射用水,搅拌使其溶解,进一步加注射用水至1000ml,再加入1g~1.5g针用活性炭,充分搅拌30~50分钟;脱炭过滤;用0.22~0.24μm微孔滤膜过滤;冷冻干燥得无菌粉末,分装灌封。
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104873944A (zh) * | 2015-06-11 | 2015-09-02 | 山东新希望六和集团有限公司 | 一种用于治疗牛前胃弛缓的药物组合物及其制备方法 |
CN105267688A (zh) * | 2015-12-04 | 2016-01-27 | 山东新希望六和集团有限公司 | 用于治疗猪水肿的药物及其制备方法 |
CN105412730A (zh) * | 2015-12-04 | 2016-03-23 | 山东新希望六和集团有限公司 | 用于治疗仔猪水肿病的药物及其制备方法 |
CN106267178A (zh) * | 2016-09-30 | 2017-01-04 | 安徽华澳生物技术有限公司 | 一种治疗猪支原体肺炎的血清制备方法 |
CN106578397A (zh) * | 2017-02-09 | 2017-04-26 | 安徽菲扬农业科技有限公司 | 一种预防母猪水肿的饲料添加剂 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102293871A (zh) * | 2011-08-22 | 2011-12-28 | 格特生物制药(天津)有限公司 | 一种治疗仔猪水肿病的中药组合物 |
CN102784306A (zh) * | 2012-08-31 | 2012-11-21 | 山东新希望六和集团有限公司 | 用于治疗仔猪水肿病的中药组合物、饲料和其制备方法 |
CN103405521A (zh) * | 2013-08-01 | 2013-11-27 | 格特生物制药(天津)有限公司 | 一种治疗猪水肿病的中药口服液及其制备方法 |
-
2014
- 2014-11-27 CN CN201410694210.5A patent/CN104383188A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102293871A (zh) * | 2011-08-22 | 2011-12-28 | 格特生物制药(天津)有限公司 | 一种治疗仔猪水肿病的中药组合物 |
CN102784306A (zh) * | 2012-08-31 | 2012-11-21 | 山东新希望六和集团有限公司 | 用于治疗仔猪水肿病的中药组合物、饲料和其制备方法 |
CN103405521A (zh) * | 2013-08-01 | 2013-11-27 | 格特生物制药(天津)有限公司 | 一种治疗猪水肿病的中药口服液及其制备方法 |
Non-Patent Citations (5)
Title |
---|
战志华等: "水肿用药配伍规律及祖方探源", 《中国中医基础医学杂志》 * |
李美珍等: "水肿病组方用药规律探析", 《湖南中医药导报》 * |
汪毅: "《中国天然药物彩色图集 第一卷》", 30 November 2010, 贵州科技出版社 * |
蔡向红: "《本草纲目方药精选》", 31 May 2014, 陕西科学技术出版社 * |
陈念祖: "《中医养生诊疗三字经》", 31 January 2003, 上海古籍出版社 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104873944A (zh) * | 2015-06-11 | 2015-09-02 | 山东新希望六和集团有限公司 | 一种用于治疗牛前胃弛缓的药物组合物及其制备方法 |
CN105267688A (zh) * | 2015-12-04 | 2016-01-27 | 山东新希望六和集团有限公司 | 用于治疗猪水肿的药物及其制备方法 |
CN105412730A (zh) * | 2015-12-04 | 2016-03-23 | 山东新希望六和集团有限公司 | 用于治疗仔猪水肿病的药物及其制备方法 |
CN106267178A (zh) * | 2016-09-30 | 2017-01-04 | 安徽华澳生物技术有限公司 | 一种治疗猪支原体肺炎的血清制备方法 |
CN106578397A (zh) * | 2017-02-09 | 2017-04-26 | 安徽菲扬农业科技有限公司 | 一种预防母猪水肿的饲料添加剂 |
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