CN104367796A - 一种治疗口腔溃疡的中药组合物 - Google Patents

一种治疗口腔溃疡的中药组合物 Download PDF

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CN104367796A
CN104367796A CN201410710603.0A CN201410710603A CN104367796A CN 104367796 A CN104367796 A CN 104367796A CN 201410710603 A CN201410710603 A CN 201410710603A CN 104367796 A CN104367796 A CN 104367796A
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蒙毅嘉
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Nanjing Julitang Pharmacy Co ltd
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Abstract

本发明公开了一种治疗口腔溃疡的中药组合物，包括以下重量份的组分：青黛3～8份、麦冬2～8份、石椒草1～5份、鱼腥草1～5份、黄芩1～3份、板蓝根1～3份、连翘2～5份、金银花1～4份、丹参2～4份、三七5～8份、穿心莲3～5份、路边青1～3份。本发明的药物具有清热解毒、活血消肿、疏散风热、清肝泻火以及滋阴润肺、补益肝肾、健脾和胃的功效，申请人通过大量的实验研究证实本产品镇痛效果好，局部镇痛刺激性小，而且伤口愈合较快。

Description

一种治疗口腔溃疡的中药组合物
技术领域
本发明属于中药技术领域，具体涉及一种治疗口腔溃疡的中药组合物。
背景技术
口腔溃疡是口腔黏膜疼痛性、复发性、单发或多发性溃疡，是口腔粘膜病中最常见的一种疾病，好发于口腔后部、颊、咽旁、硬腭或软腭交接处，其临床症状以灼痛、溃疡反复发作为主。口腔溃疡病因发杂，可能与病毒感染、细菌感染以及机体的内分泌紊乱、免疫功能失调等因素有关。一般口腔溃疡以局部治疗为主，目前一般使用含青黛、白矾和冰片的口腔溃疡散，用于治疗疱疹性口腔溃疡，疗效确切，但由于其口感、使用及局部刺激性等原因，患者的依从性较差。
发明内容
本发明要解决的技术问题是提供一种镇痛效果好，局部镇痛刺激性小，而且伤口愈合较快的治疗口腔溃疡的中药组合物。
本发明提供的技术方案是一种治疗口腔溃疡的中药组合物，包括以下重量份的组分：青黛3～8份、麦冬2～8份、石椒草1～5份、鱼腥草1～5份、黄芩1～3份、板蓝根1～3份、连翘2～5份、金银花1～4份、丹参2～4份、三七5～8份、穿心莲3～5份、路边青1～3份。
作为优选，还包括以下重量份的组分：冰片1～5份。
作为优选，还包括以下重量份的组分：罗汉果1～5份。
作为优选，所述组分的重量份为：青黛6份、麦冬3份、石椒草2.5份、鱼腥草3份、黄芩2.5份、板蓝根1.2份、连翘3份、金银花3.5份、丹参2.5份、三七7份、穿心莲4份、路边青2份。
进一步优选，所述组分的重量份为：青黛6份、麦冬3份、石椒草2.5份、鱼腥草3份、黄芩2.5份、板蓝根1.2份、连翘3份、金银花3.5份、丹参2.5份、三七7份、穿心莲4份、路边青2份、冰片1.2份。
进一步优选，所述组分的重量份为：青黛6份、麦冬3份、石椒草2.5份、鱼腥草3份、黄芩2.5份、板蓝根1.2份、连翘3份、金银花3.5份、丹参2.5份、三七7份、穿心莲4份、路边青2份、罗汉果3.8份。
本发明的药物具有清热解毒、活血消肿、疏散风热、清肝泻火以及滋阴润肺、补益肝肾、健脾和胃的功效，申请人通过大量的实验研究证实本产品镇痛效果好，局部镇痛刺激性小，而且伤口愈合较快。
具体实施方式
以下具体实施例对本发明作进一步阐述，但不作为对本发明的限定。
实施例1
将青黛3kg、麦冬2kg、石椒草1kg、鱼腥草1kg、黄芩1kg、板蓝根1kg、连翘2kg、金银花1kg、丹参2kg、三七5kg、穿心莲3kg、路边青1kg混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实施例2
将青黛8kg、麦冬8kg、石椒草5kg、鱼腥草5kg、黄芩3kg、板蓝根3kg、连翘5kg、金银花4kg、丹参4kg、三七8kg、穿心莲5kg、路边青3kg混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实施例3
将青黛6kg、麦冬3kg、石椒草2.5kg、鱼腥草3kg、黄芩2.5kg、板蓝根1.2kg、连翘3kg、金银花3.5kg、丹参2.5kg、三七7kg、穿心莲4kg、路边青2kg混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实施例4
将青黛3kg、麦冬8kg、石椒草1kg、鱼腥草5kg、黄芩1kg、板蓝根3kg、连翘2kg、金银花4kg、丹参2kg、三七8kg、穿心莲3kg、路边青3kg、冰片1kg混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实施例5
将青黛6kg、麦冬3kg、石椒草2.5kg、鱼腥草3kg、黄芩2.5kg、板蓝根1.2kg、连翘3kg、金银花3.5kg、丹参2.5kg、三七7kg、穿心莲4kg、路边青2kg、冰片1.2kg。混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实施例6
将青黛6kg、麦冬3kg、石椒草2.5kg、鱼腥草3kg、黄芩2.5kg、板蓝根1.2kg、连翘3kg、金银花3.5kg、丹参2.5kg、三七7kg、穿心莲4kg、路边青2kg、罗汉果3.8kg混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实施例7
将青黛6kg、麦冬3kg、石椒草2.5kg、鱼腥草3kg、黄芩2.5kg、板蓝根1.2kg、连翘3kg、金银花3.5kg、丹参2.5kg、三七7kg、穿心莲4kg、路边青2kg、冰片1.2kg、罗汉果3.8kg混合粉碎后，置于容器中，加入投料量10倍的水煎煮2次，第一次煎煮1h，第二次煎煮45min，合并煎煮液，过滤，将滤液浓缩至60℃相对密度为1.05的浸膏，加入辅料，压制成片，每片0.5g。
实验例
1、临床病例
挑选年龄18～60岁，身体健康的单纯性口腔溃疡患者120人，随机分为4组，每组30人，分别为实验组1～4。实验组1～4分别服用实施例1、3、5、7制得的中药组合物。
2、诊断标准
参照《中医病症诊断疗效标准》：
2.1以口腔黏膜出现单个或数个直径3～5mm的溃疡，灼热疼痛为主要症状；
2.2起病较快，一般7天左右愈合，若此起彼伏，则病程延长，愈后容易复发；
2.3口腔检查：口腔黏膜溃疡较表浅，圆形或椭圆形，数量少则1～2个，多则10余个，表面有淡黄色分泌物附着，溃疡周围黏膜大多充血。
3、治疗方法
本实施例1、3、5、7制得的中药组合物，每日3次，每次1粒，口服，5天为一个疗程，连续服用3个疗程。
4、疗效标准
痊愈—口腔溃疡愈合，局部无不适感；
好转—口疮虽然有时复发，但数量减少，程度减轻；
无效—口疮症状及溃疡无明显变化。
5、治疗结果
组别 痊愈 好转 无效 总有效率(％)
实验组1 12 15 3 90
实验组2 15 13 2 93.3
实验组3 16 12 2 93.3
实验组4 22 7 1 96.7

Claims (6)

1.一种治疗口腔溃疡的中药组合物，其特征在于：包括以下重量份的组分：青黛3～8份、麦冬2～8份、石椒草1～5份、鱼腥草1～5份、黄芩1～3份、板蓝根1～3份、连翘2～5份、金银花1～4份、丹参2～4份、三七5～8份、穿心莲3～5份、路边青1～3份。
2.根据权利要求1所述的治疗口腔溃疡的中药组合物，其特征在于：还包括以下重量份的组分：冰片1～5份。
3.根据权利要求1或2所述的治疗口腔溃疡的中药组合物，其特征在于：还包括以下重量份的组分：罗汉果1～5份。
4.根据权利要求1所述的治疗口腔溃疡的中药组合物，其特征在于：所述组分的重量份为：青黛6份、麦冬3份、石椒草2.5份、鱼腥草3份、黄芩2.5份、板蓝根1.2份、连翘3份、金银花3.5份、丹参2.5份、三七7份、穿心莲4份、路边青2份。
5.根据权利要求2所述的治疗口腔溃疡的中药组合物，其特征在于：冰片为1.2重量份。
6.根据权利要求3所述的治疗口腔溃疡的中药组合物，其特征在于：罗汉果为3.8重量份。
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CN105233006A (zh) * 2015-08-03 2016-01-13 程玉凤 一种外用中药膏及其制备方法
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CN108420936A (zh) * 2017-04-19 2018-08-21 陈甲芳 一种治疗口腔溃疡的中药散剂
CN107158218A (zh) * 2017-06-07 2017-09-15 湖南云从科技有限公司 一种治疗口腔溃疡的喷剂药方及其制备方法
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