CN104365650A - Synergistic insecticidal composition containing chloropyridine and dinotefuran - Google Patents
Synergistic insecticidal composition containing chloropyridine and dinotefuran Download PDFInfo
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- CN104365650A CN104365650A CN201410580630.0A CN201410580630A CN104365650A CN 104365650 A CN104365650 A CN 104365650A CN 201410580630 A CN201410580630 A CN 201410580630A CN 104365650 A CN104365650 A CN 104365650A
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- pyridine
- mti
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- piperazine worm
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Abstract
The invention provides a synergistic insecticidal composition containing chloropyridine and dinotefuran. The composition contains an active ingredient A and an active ingredient B, wherein the active ingredient A is chloropyridine; the active ingredient B is dinotefuran; the weight ratio of the active ingredient A to the active ingredient B is (1 to 90)-(1 to 90), preferably (1 to 50)-(1 to 50); the total weight percentage of the two active ingredients in the composition is 5-70%. The dosage forms of the composition are one or more of wettable powder, suspending agents, microemulsion, emulsion in water and water dispersible granules. The composition can be used for controlling plant hoppers or aphids harming various crops.
Description
Technical field
The present invention relates to a kind of agricultural insecticidal composite, particularly relate to a kind of Synergistic insecticidal composition containing the pyridine of piperazine worm and MTI-446, can be used for control pest, particularly plant hopper and aphid.
Background technology
The pyridine of piperazine worm is the novel nicotinamide insecticide of efficient, wide spectrum, the low toxicity of Ke Sheng group exploitation, is mainly used in preventing and treating homoptera pest.Current Imidacloprid is one of insecticide variety that consumption is maximum in the world, but because it uses in a large number frequently, cause significant resistance in the world, and the activity that piperazine worm pyridine antagonism inhales juice class pest is significantly higher than Imidacloprid, therefore the pyridine of piperazine worm is one of desirable kind replacing Imidacloprid Contol ofCotton plant hopper and aphid.Piperazine worm pyridine chemical name is: 1-((6-chloropyridine-3-base) methyl)-5-propoxyl group-7-methyl-8-nitro-1,2,3,5,6,7-six hydrogen imidazoles [1,2-a] pyridine.Its molecular structural formula is:
MTI-446, English common name (dinotefuran), chemical name 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine.The chemical constitution of itself and existing nicotinic insecticide is far from each other, and its tetrahydrofuran base instead of former chloro-pyridine base, chloro-thiazole base, not containing halogen.Meanwhile, also different with nicotine at aspect of performance, so people are referred to as " furans nicotine " at present.Its molecular structural formula is:
MTI-446 insecticidal spectrum is wide, has remarkable interior suction osmosis, and namely shows very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, to crop without poisoning, can be used for numerous crops such as paddy rice, fruit tree, vegetables.
At present, agricultural chemicals does the Main Means application of agricultural pests widely as chemical control.But the agricultural chemicals of Long-Time Service single variety, easily impels insect to produce certain resistance, peasant household is often through adopting the consumption mode increasing the weight of agricultural chemicals for this reason, to reach the object eliminated destructive insects.But adopt and just also exist in this way, larger pollution and the problem of residue of pesticide are caused to environment, also indirectly improve the drug cost of peasant household simultaneously.
There is not been reported for the complex composition of the pyridine of current piperazine worm and MTI-446.
Summary of the invention
The object of this invention is to provide a kind of mixed ratio reasonable, control efficiency is good, the synergetic pesticide composition that drug cost is low.
Another object of the present invention is to provide this composition pesticide for preventing and treating the purposes of plant hopper and aphid.
Technical scheme of the present invention is as follows: a kind of synergic agricultural pesticide composition, it is characterized in that, containing active components A and active component B, active components A refers to the pyridine of piperazine worm, and active component B refers to MTI-446, the weight ratio of active component is 1: 90 ~ 1: 90, and preferred weight ratio is 1: 50 ~ 1: 50.Composition pesticide of the present invention can according to method well-known in the art be mixed with in suspending agent, water dispersible granules, wetting powder, microemulsion and aqueous emulsion one or more, in preparation, the gross weight percentage composition of active ingredient is 5% ~ 70%, and all the other are allow in agricultural chemicals to use and acceptable auxiliary element.
Preparation is prepared in a known manner, normally active component is fully mixed with surfactant, solvent or solid carrier or grind, granulation.The auxiliary agent used in composition of the present invention comprises solvent, cosolvent, dispersant, emulsifier, wetting agent, stabilizing agent, antifreezing agent, thickener, defoamer, filler etc. and other is of value to the known substance that active ingredient is stablized in the formulation and drug effect plays, all various compositions that are conventional in pesticidal preparations or permission use, be not particularly limited, concrete composition and consumption are determined by test according to recipe requirements.
Instant component is reasonable, good disinsection effect, drug cost is low, active components A and B have significant synergies, compared with prior art, beneficial effect of the present invention is: 1. compared with single dose, said composition antagonism insect, as plant hopper and aphid have obvious synergistic effect, improve control efficiency; 2. two kinds of active ingredient mixtures, decrease dosage, thus reduce cost and alleviate the pollution to environment; 3. composition is made up of the active ingredient that two kinds of mechanism of action are different, is conducive to the pesticide resistance overcoming and delay insect; 4. possesses quick-acting and long-acting two major features simultaneously.
Embodiment
Below in conjunction with example, the invention will be further described.But the present invention is only limitted to absolutely not these examples.In all formulas, percentage or proportioning are weight percentage or weight ratio.The processing technology of the various preparation of the present composition and equipment are that the public is known.
1, the preparation of aqueous emulsion
By active component dissolution with solvents, add emulsifier for mixing to transparent in oil phase, antifreezing agent will be stablized and mix with water homogeneous as aqueous phase.Under 3000 ~ 6000 revs/min of shear conditions, oil phase is slowly added in aqueous phase and stirs 20 ~ 50 minutes, form the aqueous emulsion of favorable dispersibility.
Example of formulations 1:20% piperazine worm pyridine MTI-446 aqueous emulsion
Piperazine worm pyridine (active component) 5%
MTI-446 (active component) 15%
Trimethylbenzene (solvent) 15%
Sodium alkyl benzene sulfonate (emulsifier) 8%
Glycerine (stablizing antifreezing agent) 5%
Water complements to 100%
2, the preparation of microemulsion
Active component solvent, cosolvent are dissolved, adds emulsifier for mixing to transparent in oil phase, antifreezing agent will be stablized and mix with water homogeneous as aqueous phase.Oil phase is slowly added drop-wise in aqueous phase, stirs the microemulsion that 30 ~ 60 minutes form favorable dispersibility.
Example of formulations 2:30% piperazine worm pyridine dinotefuran micron-emulsion
Piperazine worm pyridine (active component) 10%
MTI-446 (active component) 20%
Acetone (solvent) 15%
DMF (cosolvent) 5%
Phenethyl phenol polyethenoxy ether (emulsifier) 10%
Agriculture breast 500# (emulsifier) 5%
Ethylene glycol (stablizing antifreezing agent) 2%
Water complements to 100%
3, the preparation of suspending agent
Active component, dispersant, wetting agent, thickener and water are mixed in the ratio of formula successively, after sand mill grinding, obtains suspending agent.
Example of formulations 3:24% piperazine worm pyridine MTI-446 suspending agent
Piperazine worm pyridine (active component) 8%
MTI-446 (active component) 16%
Sodium alkyl benzene sulfonate (dispersant) 6%
Alkylphenol polyoxyethylene (wetting agent) 4%
Xanthans (thickener) 0.3%
Water complements to 100%
4, the preparation of wetting powder
The ratio in formula such as active component, dispersant, wetting agent and filler is fully mixed, below ultra-fine pulverizer disintegrating to 20 μm, obtains wetting powder.
Example of formulations 4:18% piperazine worm pyridine MTI-446 wetting powder
Piperazine worm pyridine (active ingredient) 8%
MTI-446 (active ingredient) 10%
Sodium lignin sulfonate (dispersant) 5%
Lauryl sodium sulfate (wetting agent) 2%
Kaolin (filler) complements to 100%.
5, the preparation of water dispersible granules
Active component, dispersant, wetting agent, binding agent, disintegrant and the filler ratio in formula is added in blender successively, mix, particle diameter less than 10 μm Wettable Powder are become through air-flow crushing, material is made in the water mixing extruding adding 5% ~ 15% again, obtains water-dispersible granules after drying screening.
Example of formulations 5:33% piperazine worm pyridine MTI-446 water dispersible granules
Piperazine worm pyridine (active component) 13%
MTI-446 (active component) 20%
Sodium lignin sulfonate (dispersant) 3%
Rope uncle SOPA (dispersant) 3%
Sldium lauryl sulfate (wetting agent) 2%
Sodium silicate (binding agent) 1.5%
Calcium chloride (disintegrant) 5%
Precipitated calcium carbonate (filler) complements to 100%
Biologicall test and test of pesticide effectiveness example:
1, the pyridine of piperazine worm and the composite Toxicity Determination to brown planthopper of MTI-446
The former medicine that the former medicine of test medicine piperazine worm pyridine adopts Kesheng Group Co., Ltd., Jiangsu Prov. to produce, the former medicine that the former medicine of MTI-446 adopts Yin Jie Chemical Co., Ltd. of Jingzhou City to produce.After former medicinal organic solvent acetone is mixed with mother liquor with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T 1154.11-2008 " by test method, the twen-80 aqueous solution with 0.1% configures 5 series mass concentration by the method for geometric ratio.Brown Planthopper 3 nymph in age that examination worm is indoor feeding, physiological status is consistent.Choose the rice seedlings in tillering stage that the stalwartness of laboratory cultures is consistent, grub out, clean, be cut into 10cm long band root rice stem, dry in the air in shady and cool place anhydrous to surface, rice stem is flooded 30s in the medicament configured, taking-up is dried, and encases root moisturizing with absorbent cotton, outsourcing preservative film, be placed in test tube, the strain of every test tube 3.Often process 4 repetitions, and establish the process not containing medicament not do blank.To try worm with pest sucking device to move in test tube, 15, every test tube, mouth of pipe gauze covers.Examination worm after process is placed in temperature (25 ± 1) DEG C, relative moisture 60% ~ 80%, and periodicity of illumination is raise under L: D=(16: 8) h and observe.
Carry out the toxicity test of mixture according to mixed ratio by single dose toxicity test method.Be independent variable X with the logarithm value of drug concentration (mg/L), with the probability value of corrected mortality for dependent variable Y, set up virulence regression equation formula respectively, adopt DPS software to calculate the LC of single dose and each proportioning mixture
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
Co-toxicity coefficient CTC computing formula is as follows: (with the pyridine of piperazine worm for standard agent, its toxicity index is 100):
The LC of toxicity index (the TI)=piperazine worm pyridine of MTI-446
50the LC of ∕ MTI-446
50× 100
The LC of actual measurement toxicity index (the ATI)=piperazine worm pyridine of M
50the LC of ∕ M
50× 100
TI × P piperazine worm pyridine+MTI-446 TI × P MTI-446 of theoretical toxicity index (the TTI)=piperazine worm pyridine of M
TTI × 100 of the ATI ∕ M of co-toxicity coefficient (the CTC)=M of M
In formula: M is the mixture of the pyridine of piperazine worm and MTI-446 different ratio
The pyridine of P piperazine worm is the ratio of piperazine worm pyridine shared by mixture
P MTI-446 is the ratio of MTI-446 shared by mixture
Joint toxicity measuring result to Brown Planthopper: in table 1
the composite joint toxicity measuring to Brown Planthopper of table 1, the pyridine of piperazine worm and MTI-446
As seen from Table 1, piperazine worm pyridine and MTI-446 is composite has very high synergistic effect to Brown Planthopper.When the pyridine of piperazine worm and MTI-446 proportioning are 5: 1, co-toxicity coefficient reaches more than 120.
2, the pyridine of piperazine worm and the various proportioning of MTI-446 are to the field efficiency test of Brown Planthopper.
Trial crops is paddy rice, and controlling object is Brown Planthopper.By embodiment 1,2,3,4,5 totally 5 kinds of medicaments carry out after respectively water evenly being diluted spraying process, if medicament contrast and blank clear water contrast.Group arrangement in random district between process, often kind of process repeats for three times.1 day, 3 days and 7 days investigation number of pest after medicine respectively, calculate lethality and control efficiency, result of the test is as shown in table 2.
after table 2 different disposal medicine, 1d, 3d and 7d are to the field test results of Brown Planthopper
Note: in table, data are repeat mean value 3 times.
As can be seen from the result of the test of table 2, after medicine, the preventive effect of the 1st day, 3 days, 7 days each example of formulations 1,2,3,4,5 pairs of Brown Planthoppers is all apparently higher than the preventive effect of 10% piperazine worm pyridine suspending agent, 20% MTI-446 solvable pulvis two single dose, shows that two kinds of composite reagent synergy are obvious.
3, the pyridine of piperazine worm and the various proportioning of MTI-446 are to the field efficiency test of wheat aphid.
Test controlling object wheat aphid.By embodiment 1,2,3,4,5 totally five kinds of medicaments carry out after respectively water evenly being diluted spraying process, if medicament contrast and blank clear water contrast.Group arrangement in random district between process, often kind of process repeats for three times.1 day, 3 days and 7 days investigation number of pest after medicine respectively, calculate lethality and control efficiency, result of the test is as shown in table 3.
after table 3, different disposal medicine, 1d, 3d and 7d are to the field test results of wheat aphid
Note: in table, data are repeat mean value 3 times.
As can be seen from the result of the test of table 3, after medicine, the preventive effect of the 1st day, 3 days, 7 days each example of formulations 1,2,3,4,5 pairs of wheat aphids is all apparently higher than the preventive effect of 10% piperazine worm pyridine suspending agent, 20% MTI-446 solvable pulvis two single dose, shows that two kinds of composite reagent synergy are obvious.
In sum, the present invention contains the Pesticidal combination of the pyridine of piperazine worm and MTI-446, good control efficiency is had to rice fulgorid, aphid, complex preparation not only increases preventive effect, and expands insecticidal spectrum, widens the scope of application, reduce costs, the double effect controlled of one medicine is played to multiple insect pest, alleviates manpower and materials, improve productivity effect.So the invention of this complex preparation is of great significance social tool with popularization.
Claims (4)
1. a synergic agricultural pesticide composition, it is characterized in that containing active components A and B, active components A refers to the pyridine of piperazine worm, and active component B refers to MTI-446, the weight ratio of active components A and B is 1: 90 ~ 1: 90, two kinds of active components gross weight percentage composition is in the composition 5% ~ 70%.
2. Pesticidal combination according to claim 1, is characterized in that: the preferred weight ratio of active components A and B is 1: 50 ~ 1: 50.
3. the Pesticidal combination according to any one of claim 1 and 2, is characterized in that: the formulation of described composition pesticide is the one in suspending agent, water dispersible granules, wetting powder, microemulsion and aqueous emulsion.
4. the purposes of the Pesticidal combination described in any one of claim 1 and 2 in control plant hopper and aphid.
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| CN201410580630.0A CN104365650A (en) | 2014-10-27 | 2014-10-27 | Synergistic insecticidal composition containing chloropyridine and dinotefuran |
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| CN201410580630.0A CN104365650A (en) | 2014-10-27 | 2014-10-27 | Synergistic insecticidal composition containing chloropyridine and dinotefuran |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856033A (en) * | 2010-06-29 | 2010-10-13 | 江苏克胜集团股份有限公司 | Novel nicotine pesticide combination containing 1-[(6-Chloropyridin-3-yl)methyl]-7- methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo [1,2-Alpha] pyridine |
| CN103636659A (en) * | 2013-11-21 | 2014-03-19 | 张晓强 | Pesticide composition containing 1-(6-chloro-3-methylpyridyl)-8-nitro-7-methyl-1,2,3,4,5,6,7-hexahydroimidazo[1,2-a]pyridine and dinotefuran |
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2014
- 2014-10-27 CN CN201410580630.0A patent/CN104365650A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856033A (en) * | 2010-06-29 | 2010-10-13 | 江苏克胜集团股份有限公司 | Novel nicotine pesticide combination containing 1-[(6-Chloropyridin-3-yl)methyl]-7- methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo [1,2-Alpha] pyridine |
| CN103636659A (en) * | 2013-11-21 | 2014-03-19 | 张晓强 | Pesticide composition containing 1-(6-chloro-3-methylpyridyl)-8-nitro-7-methyl-1,2,3,4,5,6,7-hexahydroimidazo[1,2-a]pyridine and dinotefuran |
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Application publication date: 20150225 |