CN104352665A - 气血两虚型风湿性心脏病补益心脾制剂及制备方法 - Google Patents
气血两虚型风湿性心脏病补益心脾制剂及制备方法 Download PDFInfo
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Abstract
本发明公开了一种气血两虚型风湿性心脏病补益心脾制剂，主要由下列原料药制备而成，均为重量份：黄芪20-40，党参6-18，巴戟天8-16，五叶壁藤5-12，白术10-15，当归9-12，牛毛七10-15，甘草（炙）6-10，独行千里5-12，茯神8-14，远志4-9，白芥子8-12，桂枝6-13，胖血藤6-9，狮子七6-12，紫厚朴3-6。本发明具有补益心脾，益气安神，温通经脉功效，纯天然，制备成本低，安全性高，且疗效好，防复发。
Description
技术领域
本发明涉及中医中药领域，特别是涉及一种治疗气血两虚型风湿性心脏病的补益心脾制剂及其制备方法。
背景技术
风湿性心脏病简称风心病，是指由于风湿热活动，累及心脏瓣膜而造成的心脏瓣膜病变。表现为二尖瓣、三尖瓣、主动脉瓣中有一个或几个瓣膜狭窄和（或）关闭不全。临床上狭窄或关闭不全常同时存在，但常以一种为主。风湿性心脏病是甲组乙型溶血性链球菌感染引起的变态反应的部分表现，属于自身免疫性疾病。心脏部位的病理变化主要发生在心脏瓣膜部位。二尖瓣为最常见受累部位。患病初期常常无明显症状，后期则表现为心悸、气促、呼吸困难、胸痛、头晕、水肿、咳嗽、心瘴、乏力、咳嗽、下肢水肿、咳粉红色泡沫痰等心功能失代偿的表现。本病多发于冬春季节，寒冷、潮湿和拥挤环境下，初发年龄多在5～15岁，复发多在初发后3～5年内。中医学认为风湿性心脏病多属于“怔忡”、“喘证”、“水肿”、“心痹”等范畴。其病机主要是风寒湿邪内侵，久而化热或风湿热邪直犯，内舍于心，乃致心脉痹阻，血脉不畅，血行失度，心失所养，心神为之不安，表现心悸、怔忡，甚而阳气衰微不布，无以温煦气化，而四肢逆冷，面色苍白，颧面暗红，唇舌青紫。水湿不化，内袭肺金，外则泛溢肌肤四肢或下走肠间，见到浮肿，咳嗽气短，胸闷脘腹痞胀，不能平卧等症。中医将此病分为心血瘀阻型、气血两虚型和心肾阳虚型。其中气血两虚型主要表现为心悸气短、头昏乏力、面色无华、睡眠欠佳、舌质淡红、脉细弱。治疗原则为补血养心，益气安神。
公开号CN 104056038 A（申请号201410255486.3）的中国专利文献公开了一种治疗风湿性心脏病的中药配方，配方包括：炙甘草，阿胶，党参，生地，桂枝，麦冬，柴胡，五加皮，丹参。授权公开号CN 103191402 A（申请号201310155159.6）的中国专利文献公开了一种治疗风湿性心脏病的药物及其制备方法，主要是由鸡冠花、黄芪、茶树根、玉竹、梨叶、桃仁、松节和川牛膝按一定重量配比制备而成。公告号CN 102145070 A（申请号201110092312.6）的中国专利文献公开了一种治疗风湿性心脏病的中药，该中药由原料桑叶2-4份、鬼针草2-4份、陈皮1-3份、荆花4-6份和白棘0.5-2份制得。
目前，西医治疗风湿性心脏病，常用药有消心痛、氨酰心安、卡托普利等，这些药价钱昂贵，且副作用较大，中药治疗此病常用药有归脾丸、炙甘草汤、黄连阿胶汤等。但这些药治愈率较低，只能减轻患者的痛苦，不能治愈，疗效难以达到理想的效果，因此，具有较好疗效的中医配方还有待发掘。
发明内容
针对现有技术的缺陷，本发明的目的是提供一种制备简单、便宜安全、易久服的治疗气血两虚型风湿性心脏病的补益心脾制剂及其制备方法。该补益心脾制剂，疗效显著且无毒副作用。
本发明的技术方案是:
气血两虚型风湿性心脏病的补益心脾制剂，主要由下列原料药制备而成，均为重量份：黄芪20-40，党参6-18，巴戟天8-16，五叶壁藤5-12，白术10-15，当归9-12，牛毛七10-15，甘草（炙）6-10，独行千里5-12，茯神8-14，远志4-9，白芥子8-12，桂枝6-13，胖血藤6-9，狮子七6-12，紫厚朴3-6。
优选的方案中，黄芪25-35，党参10-14，巴戟天10-14，五叶壁藤7-10，白术11-14，当归10-11，牛毛七11-14，甘草（炙）7-9，独行千里7-10，茯神10-12，远志5-8，白芥子9-11，桂枝8-11，胖血藤7-8，狮子七8-10，紫厚朴4-5。
更加优选的，黄芪30，党参12，巴戟天12，五叶壁藤8.5，白术12.5，当归10.5，牛毛七12.5，甘草（炙）8，独行千里8.5，茯神11，远志6.5，白芥子10，桂枝9.5，胖血藤7.5，狮子七9，紫厚朴4.5。
本发明还提供了将前述补益心脾制剂制成药学上可接受的汤剂、胶囊、粉剂、或丸剂的制备方法。
所述汤剂的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸10-15分钟（优选12分钟），取出，晒干；
（2） 将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）、（3）所制得的药材一起放置非铁质容器内，加水浸渍3-6小时（优选4小时），然后大火煮开，加入茯神和30ml姜汁，转小火煎40-60分钟（优选50分钟），过滤，收集滤液；
（5）将余渣兑水再次煎煮30-50分钟（优选40分钟），过滤，合并两次滤液，减压浓缩至原体积的四分之一，即得中药制剂汤剂。
所述胶囊的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸10-15分钟（优选12分钟），取出，晒干；
（2）将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）和（3）所制得的药材一起放置非铁质容器内，加水浸渍3-6小时（优选4小时），然后武火煮开，加入茯神，转小火煎40-60分钟（优选50分钟），过滤，收集滤液；
（5）将步骤（4）所得滤液减压浓缩成清膏，加入清膏质量0.7倍的蔗糖和等质量的糊精，拌匀，干燥，粉碎，制粒，干燥，整粒，装入胶囊中，即得中药制剂胶囊。
所述的汤剂和胶囊的制备方法，步骤（4）浸渍时水面高出药材3厘米。
所述粉剂的制备方法是：
（1）将党参、巴戟天、白术、当归、炙甘草、茯神、白芥子和桂枝去杂质，洗净烘干，一起粉碎过140-180目（优选160目）筛；
（2）将黄芪、五叶壁藤、牛毛七、独行千里、远志、胖血藤、狮子七和紫厚朴加水浸泡3-6小时（优选4小时），然后大火煮开，转小火煎 40-60分钟（优选50分钟），过滤；
（3）将步骤（2）所得滤液，喷雾干燥，粉碎过160目筛；
（4）将步骤（1）和（3）所制得药粉混合均匀，即得中药制剂粉剂。
所述丸剂的制备方法是：
（1）将党参、巴戟天、白术、当归、炙甘草、茯神、白芥子和桂枝去杂质，洗净烘干，一起粉碎过140-180目（优选160目）筛；
（2）将黄芪、五叶壁藤、牛毛七、独行千里、远志、胖血藤、狮子七和紫厚朴加水浸泡3-6小时（优选4小时），然后大火煮开，转小火煎 40-60分钟（优选50分钟），过滤；
（3）将步骤（2）所得滤液，喷雾干燥，粉碎过160目筛；
（4）将步骤（1）和（3）所制得药粉混合均匀，然后加入蜂蜜，搅拌均匀，用塑制法制得丸剂。
本发明还提供了所述的气血两虚型风湿性心脏病补益心脾制剂在制备治疗气血两虚型风湿性心脏病的药物时的应用。
本发明所用主要中药原料的药理如下：
黄芪：基原：为豆科植物蒙古黄芪或膜荚黄芪的干燥根。性味：甘，温。归经：肺经、脾经。功效：补气固表，利尿消肿，托毒排脓，敛疮生肌。主治：用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
党参：基原：为桔梗科多年生草本植物党参、素花党参、川党参及其同属多种植物的根。性味：味甘；性平。归经：归脾经；肺经。功效：健脾补肺、益气生津。主治：脾胃虚弱、食少便溏、四肢乏力、肺虚喘咳、气短自汗、气微两亏诸证。
巴戟天：基原：是茜草科植物巴戟天的干燥根。性味：辛，甘；温。归经：肝经；肾经。功效：补肾助阳、强筋壮骨、祛风除湿。主治：肾虚阳痿；遗精早泄；少腹冷痛；小便不禁；宫冷不孕；风寒湿痹；腰膝酸软；风湿肢气。
五叶壁藤：基原：葡萄科爬山虎属植物绿爬山虎的根、茎或叶。性味：辛，温。功用主治：祛风除湿，散瘀通络，解毒消肿。主治风湿痹病，腰肌劳损，四肢麻木，跌打瘀肿，骨折，毒蛇咬伤。
白术：基原：菊科植物白术，以根茎入药。性味：苦、甘，温。归经：脾经；胃经。功效：健脾益气；燥湿利水；止汗；安胎。主治：脾气虚弱；神疲乏力；食少少腹胀；大便溏薄；水饮内停；小便不利；水肿；痰饮眩晕；温痹酸痛；气虚自汗；胎动不安。
当归：基原：为伞形科植物当归的根。性味：味甘；辛；苦；性温。归经：归肝经；心经；脾经。功效：补血；活血；调经止痛；润燥滑肠。主治：血虚诸证；月经不调；经闭；痛经；癥瘕结聚；崩漏；虚寒腹痛；痿痹；肌肤麻木；肠燥便难；赤痢后重；痈疽疮疡；跌扑损伤。
牛毛七：基原：为曲尾藓科山毛藓属植物山毛藓的植物的根。性味：甘，淡，平。归经：归心、肺经。功效：祛风利湿，清热解毒。主治：感冒发热，风湿痹痛，痢疾，水肿，白带，吐血，痈肿，外伤出血，毒蛇咬伤，急惊风，破伤风，哮喘，胃痛产后风。
炙甘草：甘草：豆科植物甘草、胀果甘草或光果甘草的干燥根和根茎。性味：甘，平。归心、肺、脾、胃经。炙甘草：取甘草片，照蜜炙法(附录ⅡD)炒至黄色至深黄色，不粘手时取出，晾凉。性味：甘，平。归经：归心、肺、脾、胃经。功能与主治：补脾和胃，益气复脉。用于脾胃虚弱，倦怠乏力，心动悸，脉结代。
独行千里：基原：白花菜科山柑属植物独行千里的根。成分：含生物碱、氨基酸、有机酸等。药性：苦、涩，微温，小毒。功用主治：活血散瘀，祛风止痛。主治跌打瘀肿，闭经，风湿痹痛，咽喉肿痛，牙痛，腹痛。
茯神：基原：茯苓菌核中间（白茯苓）抱有松根或细松木心者的部份。多切成薄方块，坚实。性味：甘淡，平。归经：入心、脾经。功效：宁心安神、利水。主治：适用于小便不利、心悸怔忡、失眠健忘等症。
远志：最早记载于《神农本草经》，列为上品，并被视为养命要药，来源于远志科植物远志和卵叶远志的干燥根。性温，味苦、辛，具有安神益智、祛痰、消肿的功能，用于心肾不交引起的失眠多梦、健忘惊悸，神志恍惚，咳痰不爽，疮疡肿毒，乳房肿痛。临床应用生远志、制远志和蜜远志三种饮片规格，但以制远志为主。
白芥子：基原：十字花科植物白芥的种子。性味：辛；温。归经：肺经；肝经；脾经；胃经；心包经。功效：化痰逐饮；散结消肿。主治：咳喘痰多；胸满胁痛；肢体麻木；关节肿痛；湿痰流注；阴疽肿毒。
桂枝：基原：为樟科植物肉桂的嫩枝。性味：辛；甘；性温。归经：膀胱经；心经；肺经。功效：散寒解表；温通经脉；促阳化气。主治：风寒表证；寒湿痹痛；四肢厥冷；经闭痛经；癥瘕结块；胸痹；心悸；痰饮；小便不利。
胖血藤：基原：为蓼科蓼属植物牛皮消蓼的根。药性：酸、辛，凉。归肺、胃经。功用主治：敛肺止咳，行气，化湿。主治肺痨咳嗽，痰中带血，百日咳，胃脘胀闷疼痛，风湿痹痛，阴疮久不收口。
狮子七：基原：为景天科红景天属植物狭叶红景天的根及根茎。成分：全草含酪醇，胡萝卜苷，红景天苷，百脉跟苷。药性：苦、涩，温。归肺、心、肝、大肠经。功用主治：养心安神，化瘀，止血。主治气虚体弱，短气乏力心悸失眠，头昏眩晕，胸闷疼痛，跌打损伤，月经不调，崩漏，吐血，痢疾，腹泻。
厚朴：基原：为木兰科植物厚朴和庐山厚朴的树皮、根皮和枝皮。 性味：苦、辛，温。归经：归脾、胃、肺、大肠经。功效：行气消积；燥湿除满；降逆平喘。主治：食积气滞；腹胀便秘；湿阻中焦，脘痞吐泻；痰壅气逆；胸满喘咳。
本发明提供的补益心脾制剂依据中医对气血两虚型风湿性心脏病治疗原则，经过长期研究得到，各种剂型的制备简单，所得产品服用方便。此外，本发明的优良效果还表现在：
1、本组方所选材料皆为传统中药材料，纯天然，安全性高；
2、本组方成本低，能够极大的减轻患者经济负担；
3、本组方具有补益心脾，益气安神，温通经脉功效。
附图说明
图1为服用实施例5所得气血两虚型风湿性心脏病补益心脾制剂汤剂心悸气促改善情况；
图2为服用实施例5所得气血两虚型风湿性心脏病补益心脾制剂汤头晕乏力改善情况。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不限于此。
实施例1 气血两虚型风湿性心脏病补益心脾制剂，主要由下列原料药制备而成：黄芪20g，党参6g，巴戟天8g，五叶壁藤5g，白术10g，当归9g，牛毛七10g，甘草（炙）6g，独行千里5g，茯神8g，远志4g，白芥子8g，桂枝6g，胖血藤6g，狮子七6g，紫厚朴3g。
上述气血两虚型风湿性心脏病补益心脾制剂汤剂的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸12分钟，取出，晒干；
（2）将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）、（3）所制得的药材一起放置非铁质容器内，加水,水面高出药材3厘米,浸渍4小时，然后大火煮开，加入茯神和30ml姜汁，转小火煎50分钟，过滤，收集滤液；
（5）将余渣兑水再次煎煮40分钟，过滤，合并两次滤液，减压浓缩至原体积的四分之一，即得中药制剂汤剂。
本发明汤剂的服用方法:汤剂为20天一个疗程，每天服用两次（温热），每次50m1-80m1。
实施例2 气血两虚型风湿性心脏病补益心脾制剂，主要由下列原料药制备而成：黄芪40g，党参18g，巴戟天16g，五叶壁藤12g，白术15g，当归12g，牛毛七15g，甘草（炙）10g，独行千里12g，茯神14g，远志9g，白芥子12g，桂枝13g，胖血藤9g，狮子七12g，紫厚朴6g。
气血两虚型风湿性心脏病补益心脾制剂胶囊的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸12分钟，取出，晒干；
（2）将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）和（3）所制得的药材一起放置非铁质容器内，加水，水面高出药材3厘米，浸渍4小时，然后武火煮开，加入茯神，转小火煎50分钟，过滤，收集滤液；
（5）将步骤（4）所得滤液减压浓缩成清膏，加入清膏质量0.7倍的蔗糖和等质量的糊精，拌匀，干燥，粉碎，制粒，干燥，整粒，装入胶囊中，即得中药制剂胶囊。
典型病例：xxx，女，46岁。主诉：患有风湿性心脏病数年，心悸气短，头晕目眩。就诊时发热，体温38.5℃，不能平卧，呼吸困难，身肿，汗出，脉细弱，两肺底湿性罗音，心尖部可听到3级双期杂音，心律不齐，下肢凹陷性水肿。确诊为风湿性心脏病属气血两虚型。
服用本实施例所得气血两虚型风湿性心脏病补益心脾制剂胶囊，每次3-5颗，每天2次，温开水冲服，20天一个疗程。服用一个疗程后心悸气短等不适症状开始改善，服用3个疗程后，各种不适症状均消除，1年后随访，未见复发。
实施例3 气血两虚型风湿性心脏病补益心脾制剂，主要由下列原料药制备而成：黄芪25g，党参10g，巴戟天10g，五叶壁藤7g，白术11g，当归10g，牛毛七11g，甘草（炙）7g，独行千里7g，茯神10g，远志5g，白芥子9g，桂枝8g，胖血藤7g，狮子七8g，紫厚朴4g。
气血两虚型风湿性心脏病补益心脾制剂粉剂的制备方法是：
（1）将党参、巴戟天、白术、当归、炙甘草、茯神、白芥子和桂枝去杂质，洗净烘干，一起粉碎过160目筛；
（2）将黄芪、五叶壁藤、牛毛七、独行千里、远志、胖血藤、狮子七和紫厚朴加水浸泡4小时，然后大火煮开，转小火煎 50分钟，过滤；
（3）将步骤（2）所得滤液，喷雾干燥，粉碎过160目筛；
（4）将步骤（1）和（3）所制得药粉混合均匀，即得中药制剂粉剂。
典型病例：xxx，男，53岁。近几日出现心慌气短，头晕乏力、浮肿、食欲不振、睡眠欠佳等症状，就诊时脉细弱，经检查诊断为气血两虚型风湿性心脏病，后服用速尿、双克等西药效果不明显，症状未得到改善。
后经打听，得知本发明配方，服用本实施例所得气血两虚型风湿性心脏病补益心脾制剂粉剂，采用每天两次，每次1-2袋，用温开水冲服，20天一个疗程。服用两个疗程后，心慌气短、乏力、浮肿等症状明显改善，继续服用两个疗程后，无不适症状，可以从事一些体力劳动和锻炼运动。
实施例4 气血两虚型风湿性心脏病补益心脾制剂，主要由下列原料药制备而成：黄芪35g，党参14g，巴戟天14g，五叶壁藤10g，白术14g，当归11g，牛毛七14g，甘草（炙）9g，独行千里10g，茯神12g，远志8g，白芥子11g，桂枝11g，胖血藤8g，狮子七10g，紫厚朴5g。
气血两虚型风湿性心脏病补益心脾制剂丸剂的制备方法是：
（1）将党参、巴戟天、白术、当归、炙甘草、茯神、白芥子和桂枝去杂质，洗净烘干，一起粉碎过160目筛；
（2）将黄芪、五叶壁藤、牛毛七、独行千里、远志、胖血藤、狮子七和紫厚朴加水浸泡4小时，然后大火煮开，转小火煎50分钟，过滤；
（3）将步骤（2）所得滤液，喷雾干燥，粉碎过160目筛；
（4）将步骤（1）和（3）所制得药粉混合均匀，然后加入蜂蜜，搅拌均匀，用塑制法制得丸剂。
典型病例：xxx，男，61岁。主诉：有风湿病史，近一个月来，身体出现浮肿，食欲不振，头晕目眩，乏力，气喘。就诊时，气促，胸痛，舌质淡红，心瘴明显，确诊为气血两虚型风湿性心脏病。
服用本实施例所得气血两虚型风湿性心脏病补益心脾制剂丸剂，采用每天两次，每次4粒，用温开水冲服，20天一个疗程。服用一个疗程后，气喘、浮肿、乏力等不适症状改善，继续服用两个疗程，所有症状完全消除，半年后随访，未复发。
实施例5 气血两虚型风湿性心脏病补益心脾制剂，主要由下列原料药制备而成：黄芪30g，党参12g，巴戟天12g，五叶壁藤8.5g，白术12.5g，当归10.5g，牛毛七12.5g，甘草（炙）8g，独行千里8.5g，茯神11g，远志6.5g，白芥子10g，桂枝9.5g，胖血藤7.5g，狮子七9g，紫厚朴4.5g。
气血两虚型风湿性心脏病补益心脾制剂汤剂的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸12分钟，取出，晒干；
（2） 将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）、（3）所制得的药材一起放置非铁质容器内，加水，水面高出药材3厘米，浸渍4小时，然后大火煮开，加入茯神和30ml姜汁，转小火煎50分钟，过滤，收集滤液；
（5）将余渣兑水再次煎煮40分钟，过滤，合并两次滤液，减压浓缩至原体积的四分之一，即得中药制剂汤剂。
试验例1 实施例5所得气血两虚型风湿性心脏病补益心脾制剂汤剂的临床应用：2012年1月-2013年12月，在6所医院筛选出468例确诊为气血两虚型风湿性心脏病的患者，其中女性216例，男性252例，年龄最大的66岁，最小年龄20岁，平均年龄43.6岁。将患者随机分为两组，实验组和对照组，实验组服用实施例5所得产品，每天服用两次（温热），每次50m1-80m1（视具体情况有所调整），20天一个疗程。对照组服用其它药品（荣心丸、消心痛、美他嗪等常规药品）。
诊断标准:活动后心悸、气促，甚至出现呼吸困难、端坐呼吸、夜间不能平卧；轻微活动或劳累后就出现咳嗽、咳痰带血丝，很容易受凉感冒，胸痛；食欲不振，消化不好，常出现肚子胀，下肢浮肿、腹胀、腹水，肝、脾肿大等；两颧及口唇呈紫红色。
疗效情况判定标准:显效:风湿性心脏病全部症状消除或主要症状消除，体质恢复正常，理化检测指标基本正常，观察半年无复发者；有效：风湿性心脏病主要症状明显好转，主要理化检测指标有所改善，体质逐步恢复；无效：不适症状无变化，主要理化检测指标与治疗前无变化。分组情况及两组治疗结果如表1所示。
表1两组分组情况及服药两个月后患者治疗结果
由表1可以看出，服药两个月后，服用实施例5所得产品的实验组患者，患者症状得到消除的有202例，占70.1%，患者症状得到明显好转的有75例，占26.1%，无效有11例，占3.8%，实验组的总有效率96.2%；服用其他常规药的对照组，效果明显不如对照组，总有效率为81.1%。
服用期间心悸气促改善情况和头晕乏力改善情况如附图1和附图2所示。
从图1 和图2中可以明显的看出，服用实施例5所得产品的实验组患者，心悸气促和头晕乏力不适症状随治疗时间的增加，得到改善的比例在不断增加，且较对照组的改善比例高。说明实施例5所得产品治疗效果较对照组药品好。
本发明组方中，党参、白术健脾补肺、益气生津；当归补血活血，调经止痛；巴戟天、五叶壁藤祛风除湿、解毒消肿；炙甘草补脾和胃、益气复脉；独行千里活血散瘀，祛风止痛；加之茯神、远志和狮子七宁心安神，胖血藤行气化湿；紫厚朴行气消积、燥湿除满。将这些药物组合使得各药物功效发生协同作用，不仅能有效的治疗气血两虚型风湿性心脏病，还能够预防其复发。
应当指出的是，具体实施方式只是本发明比较有代表性的例子，显然本发明的技术方案不限于上述实施例，还可以有很多变形。本领域的普通技术人员，以本发明所明确公开的或根据文件的书面描述毫无异议的得到的，均应认为是本专利所要保护的范围。
Claims (10)
1.气血两虚型风湿性心脏病补益心脾制剂，其特征在于，主要由下列原料药制备而成，均为重量份：黄芪20-40，党参6-18，巴戟天8-16，五叶壁藤5-12，白术10-15，当归9-12，牛毛七10-15，甘草（炙）6-10，独行千里5-12，茯神8-14，远志4-9，白芥子8-12，桂枝6-13，胖血藤6-9，狮子七6-12，紫厚朴3-6。
2.如权利要求1所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，黄芪25-35，党参10-14，巴戟天10-14，五叶壁藤7-10，白术11-14，当归10-11，牛毛七11-14，甘草（炙）7-9，独行千里7-10，茯神10-12，远志5-8，白芥子9-11，桂枝8-11，胖血藤7-8，狮子七8-10，紫厚朴4-5。
3.如权利要求1所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，黄芪30，党参12，巴戟天12，五叶壁藤8.5，白术12.5，当归10.5，牛毛七12.5，甘草（炙）8，独行千里8.5，茯神11，远志6.5，白芥子10，桂枝9.5，胖血藤7.5，狮子七9，紫厚朴4.5。
4.如权利要求1-3任一所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，将其制成药学上可接受的汤剂、胶囊、粉剂或丸剂。
5.如权利要求4所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，所述汤剂的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸10-15分钟（优选12分钟），取出，晒干；
（2）将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）、（3）所制得的药材一起放置非铁质容器内，加水浸渍3-6小时（优选4小时），然后大火煮开，加入茯神和30ml姜汁，转小火煎40-60分钟（优选50分钟），过滤，收集滤液；
（5）将余渣兑水再次煎煮30-50分钟（优选40分钟），过滤，合并两次滤液，减压浓缩至原体积的四分之一，即得中药制剂汤剂。
6.如权利要求4所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，所述胶囊的制备方法是：
（1）将巴戟天、五叶壁藤、当归、白芥子和胖血藤洗净去杂质，用酒浸润，然后置于锅中蒸10-15分钟（优选12分钟），取出，晒干；
（2）将黄芪、党参、白术和狮子七去杂质，切薄片，置于炒锅中，中火炒至表面老黄色为止，取出，晾凉；
（3）将紫厚朴用水浸泡，润透后捞出，刮去粗皮，洗净，切丝，晾干；
（4）将牛毛七、炙甘草、独行千里、远志、桂枝和步骤（1）、（2）和（3）所制得的药材一起放置非铁质容器内，加水浸渍3-6小时（优选4小时），然后武火煮开，加入茯神，转小火煎40-60分钟（优选50分钟），过滤，收集滤液；
（5）将步骤（4）所得滤液减压浓缩成清膏，加入清膏质量0.7倍的蔗糖和等质量的糊精，拌匀，干燥，粉碎，制粒，干燥，整粒，装入胶囊中，即得中药制剂胶囊。
7.如权利要求5和6所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，步骤（4）浸渍时水面高出药材3厘米。
8.如权利要求4所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，所述粉剂的制备方法是：
（1）将党参、巴戟天、白术、当归、炙甘草、茯神、白芥子和桂枝去杂质，洗净烘干，一起粉碎过140-180目（优选160目）筛；
（2）将黄芪、五叶壁藤、牛毛七、独行千里、远志、胖血藤、狮子七和紫厚朴加水浸泡3-6小时（优选4小时），然后大火煮开，转小火煎 40-60分钟（优选50分钟），过滤；
（3）将步骤（2）所得滤液，喷雾干燥，粉碎过160目筛；
（4）将步骤（1）和（3）所制得药粉混合均匀，即得中药制剂粉剂。
9.如权利要求4所述的气血两虚型风湿性心脏病补益心脾制剂，其特征在于，所述丸剂的制备方法是：
（1）将党参、巴戟天、白术、当归、炙甘草、茯神、白芥子和桂枝去杂质，洗净烘干，一起粉碎过140-180目（优选160目）筛；
（2）将黄芪、五叶壁藤、牛毛七、独行千里、远志、胖血藤、狮子七和紫厚朴加水浸泡3-6小时（优选4小时），然后大火煮开，转小火煎 40-60分钟（优选50分钟），过滤；
（3）将步骤（2）所得滤液，喷雾干燥，粉碎过160目筛；
（4）将步骤（1）和（3）所制得药粉混合均匀，然后加入蜂蜜，搅拌均匀，用塑制法制得丸剂。
10.如权利要求1-3任一所述的气血两虚型风湿性心脏病补益心脾制剂在制备治疗气血两虚型风湿性心脏病的药物时的应用。
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