CN104288377A - Medicine composition for treating cerebral thrombosis - Google Patents
Medicine composition for treating cerebral thrombosis Download PDFInfo
- Publication number
- CN104288377A CN104288377A CN201410595609.8A CN201410595609A CN104288377A CN 104288377 A CN104288377 A CN 104288377A CN 201410595609 A CN201410595609 A CN 201410595609A CN 104288377 A CN104288377 A CN 104288377A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- cerebral thrombosis
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
The invention discloses a medicine composition for treating cerebral thrombosis, and belongs to the technical field of traditional Chinese medicines. The medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-20 parts of astragalus, 5-9 parts of Chinese angelica, 3-10 parts of red paeony root, 3-6 parts of szechuan lovage rhizome, 10-20 parts of cinnamon, 5-10 parts of radix salviae miltiorrhizae, 5-10 parts of rhizoma alismatis, 3-10 parts of cortex phellodendri, 8-15 parts of capillary wormwood herb, 20-25 parts of hawthorn, 3-10 parts of uncaria, 3-5 parts of scorpion, and 2-4 parts of centipede. The medicine composition provided by the invention has the advantages that the medicinal curative effect is obvious, the effect is lasting, both symptoms and root causes can be treated, side effects do not exist, the price is low, and the use is convenient, so that the medicine composition is worthy of popularization.
Description
Technical field
The present invention relates to technical field of Chinese medicine, be specifically related to a kind of pharmaceutical composition for the treatment of cerebral thrombosis.
Background technology
Cerebral thrombosis is the modal type of cerebral infarction.Be that cerebral arteries trunk or cortical branches atherosclerosis cause Aldosterone, luminal stenosis obturation and thrombosis, cause brain regional blood flow to reduce or blood supply interruption, brain tissue ischemia anoxia causes the focal neurological symptom of softening downright bad appearance.Cerebral thrombus patient's premorbid once had limbs numb, the sign such as ineffective, the slurred speech of moving, dizzy, blurred vision.Often in sleep or morbidity morning, suffering limb activity is unable or stiff, speak ambiguous or aphasia, drinks water to send out and chokes.Most patient realizes elimination or slight obstacle.Nervus facialis and hypoglossal paralysis, nystagmus, muscular tension and abdomen hyporeflexia or enhancing, pathologic reflex is positive, and stomach wall and cremasteric reflex weaken or disappear.Along with the raising of people's living standard, higher fatty acid in diet, high-cholesterol diet proportion significantly increases, the metabolism of lipid and cholesterol taken in is higher, " three-hypers " crowd quantity is caused constantly to increase, cardiovascular and cerebrovascular disease sickness rate improves, become impact is national healthy at present No.1 " killer ", cerebral thrombosis is exactly one of modal disease of cerebrovascular disease.
During the treatment of cerebral thrombosis mainly contains, doctor trained in Western medicine two kinds of Therapeutic Method, western medical treatment mainly contains the medicines such as blood vessel dilating agent, depressor and anti-platelet aggregation agent, and these medicine side effect are comparatively large, and life-time service can bring injury in various degree to human organ.Traditional Chinese medical science thrombolytic therapy energy blood circulation promoting and blood stasis dispelling, dredging brain arteries and veins, fundamentally solve the problem of cerebral thrombosis, toxic and side effects is little, not easily recurs after controlling, accept by most patient.Theory of Chinese medical science is of extensive knowledge and profound scholarship, most disease can both find therapy approach from the traditional Chinese medical science, Chinese traditional treatment more has the advantage and experience of taking stopgap measures and consolidating, treatment by Chinese herbs cerebral thrombosis method is easily accepted by the patient, the patented technology now having announced treatment cerebral thrombosis all has certain curative effect to treatment cerebral thrombosis disease, but also there is the problem that curative effect is slow, the course for the treatment of is long, medical circles' strengthening research in needs.
Summary of the invention
The present invention in order to make up the deficiencies in the prior art, provide a kind of effective, short treating period, cure rate are high, the pharmaceutical composition for the treatment of cerebral thrombosis that has no side effect.
A kind of pharmaceutical composition for the treatment of cerebral thrombosis of the present invention, is prepared from by the Chinese crude drug of following weight portion: Radix Astragali 10-20 part, Radix Angelicae Sinensis 5-9 part, Radix Paeoniae Rubra 3-10 part, Rhizoma Chuanxiong 3-6 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10-20 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Alismatis 5-10 part, Cortex Phellodendri 3-10 part, Herba Artemisiae Scopariae 8-15 part, Fructus Crataegi 20-25 part, Ramulus Uncariae Cum Uncis 3-10 part, Scorpio 3-5 part, Scolopendra 2-4 part.
Preferably, the pharmaceutical composition of above-mentioned treatment cerebral thrombosis, is prepared from by the Chinese crude drug of following weight portion: Radix Astragali 12-18 part, Radix Angelicae Sinensis 5-8 part, Radix Paeoniae Rubra 3-8 part, Rhizoma Chuanxiong 3-5 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 11-16 part, Radix Salviae Miltiorrhizae 6-10 part, Rhizoma Alismatis 7-10 part, Cortex Phellodendri 5-10 part, Herba Artemisiae Scopariae 9-14 part, Fructus Crataegi 22-25 part, Ramulus Uncariae Cum Uncis 3-8 part, Scorpio 3-4 part, Scolopendra 2-4 part.
Further preferably, the pharmaceutical composition of above-mentioned treatment cerebral thrombosis, is prepared from by the Chinese crude drug of following weight portion: Radix Astragali 14-18 part, Radix Angelicae Sinensis 5-7 part, Radix Paeoniae Rubra 3-6 part, Rhizoma Chuanxiong 3-4 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 11-14 part, Radix Salviae Miltiorrhizae 8-10 part, Rhizoma Alismatis 8-10 part, Cortex Phellodendri 5-9 part, Herba Artemisiae Scopariae 9-12 part, Fructus Crataegi 22-23 part, Ramulus Uncariae Cum Uncis 3-7 part, Scorpio 3-4 part, Scolopendra 3-4 part.
In a most preferred embodiment, the pharmaceutical composition of described treatment cerebral thrombosis, is prepared from by the Chinese crude drug of following weight portion: the Radix Astragali 15 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Chuanxiong 3 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Salviae Miltiorrhizae 9 parts, Rhizoma Alismatis 9 parts, Cortex Phellodendri 6 parts, Herba Artemisiae Scopariae 10 parts, Fructus Crataegi 23 parts, Ramulus Uncariae Cum Uncis 6 parts, Scorpio 3 parts, Scolopendra 3 parts.
Further preferably, the pharmaceutical composition of described treatment cerebral thrombosis can be made into oral formulations.
Again further preferably, described oral formulations is oral liquid, granule, tablet or capsule.
Found by clinical application research, the pharmaceutical composition be prepared from by above-mentioned Chinese crude drug obtains satisfied curative effect in treatment cerebral thrombus patient.Therefore, second object of the present invention is to provide a kind of new medical use, i.e. the application of said medicine in preparation treatment cerebral thrombosis medicine.
According to Chinese medicine Historical Data Data About, above-mentioned Chinese crude drug has following pharmacologically active and function cures mainly:
The Radix Astragali, invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.
Radix Angelicae Sinensis, Materia Medica of Decoction: Radix Angelicae Sinensis energy removing blood stasis, body can nourish blood, the promoting the circulation of blood of tail energy.If use entirely, all can enrich blood at ginseng, stilbene; Leading a cow, Radix Et Rhizoma Rhei, all can removing blood stasis, assistant makes fixed point, and user is when know.From osmanthus, attached, the Fructus Evodiae is then hot; Then tremble with fear from Radix Et Rhizoma Rhei, Natrii Sulfas.Only wine Radix Angelicae Sinensis (steamed), controls headache again, with its all headache all belong to wood, therefore with blood medicine master it.
Radix Paeoniae Rubra, clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.The peoniflorin contained in Radix Paeoniae Rubra has the effects such as antithrombus formation, antiplatelet aggregation, blood fat reducing and arteriosclerosis.
Rhizoma Chuanxiong, blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken crux stagnated blood, supports fresh blood, put on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.
Cortex cinnamomi japonici (Ramulus Cinnamomi), warming the spleen and stomach, dispersing wind and cold, promoting blood circulation.Control the cold fullness in the chest of abdomen, vomit dysphagic, rheumatic arthralgia, fall damage the stasis of blood stagnant, dysentery hemorrhoidal hamorrhage.
Radix Salviae Miltiorrhizae, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.Pharmaceutical research is thought, the Radix Salviae Miltiorrhizae in Radix Salviae Miltiorrhizae have anticoagulant, fibrinolysis enhancing and sedation, and abnormal hemorheological property is adjusted, and cerebral circulation is improved, and promotes that collateral circulation is set up, and increases the supply of blood oxygen, is conducive to cerebral tissue reparation." book on Chinese herbal medicine is newly organized ": Radix Salviae Miltiorrhizae, bitter in the mouth, feeble QI is trembled with fear, nontoxic.Enter the heart, spleen two warp.Special regulating menstruation arteries and veins, reason iliacus is ached, and tissue regeneration promoting blood, removes stagnant blood, and fall stillborn fetus, peaceful tire, and removing mass gathers disease heavily fortified point, under hemostasis metrorrhagia and leukorrhagia.The soft energy of foot numbness is good for, and eye red is swollen can disappear.Ward off smart evil spirit stealthy, support just eliminating evil, control borborygmus and also imitate.
Rhizoma Alismatis, diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Cortex Phellodendri, heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Herba Artemisiae Scopariae, has function of gallbladder promoting, promotes bile secretion, increases the effect that in bile, cholic acid and bilirubin are discharged, heart coronary flow can be increased, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.
Fructus Crataegi, promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
Ramulus Uncariae Cum Uncis, heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension." book on Chinese herbal medicine justice ": " Ramulus Uncariae Cum Uncis, namely thinks special for treating children cold and heat from " not recording ", great scape and meaning treatment children's, does not enter remaining side.This is light clear and property is sweet cold for lid gas, close most do not fill in the young the moon of child, body constitution that young YANG transmission is prosperous.The person that can control infantile convulsion, epilepsy disease is the dynamic raw wind of liver all, the disease that gas fire is burnt, and this thing is gently clear and cool, can let out fire and can subduing the wind syndrome.Zhen Quan calls main children's's night crying due to fright in infant, and Chi Zong heat is stopped up, infantile convulsive seizure due to fright erythroderma of newborn; Be on the point of lake meaning to control the large number of people and revolve dizzy, suppressing liver-wind, except heat in the heart, all carries out persistently.Only be on the point of lake and call again its macule, then this Radix Arnebiae (Radix Lithospermi) in Qian Zhongyang falls apart, and side's Ramulus Uncariae Cum Uncis hook, Lacca are divided into end, and heat wine is taken after mixing with liquid.According to the SEC Yangzhi so-called rash, is pocked and Cu, non today when the disease of the so-called hair spot, Uncaria light energy through the hair clean, antipyretic, and accompanied by shikonin cooling blood and activating blood circulation, to flow, and the wine to auxiliary, can also can clear fire, Xun is a safe method way.”
Scorpio, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Scolopendra, nature and flavor: pungent, temperature; Poisonous.Gui Jing: return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Above-mentioned each Chinese crude drug is prepared into the preparation method of compound oral liquid of the present invention, comprise the steps: to take according to quantity and clean up and the Radix Astragali of drying, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Cortex Phellodendri, Herba Artemisiae Scopariae, Fructus Crataegi, Ramulus Uncariae Cum Uncis, Scorpio, Scolopendra, merge, decoct with water twice, collecting decoction, when being evaporated to 70 DEG C, relative density is 1.15-1.20, adding ethanol makes the percent by volume of alcohol content reach 75-85%, stir, leave standstill, filter, during filtrate reduced in volume to 70 DEG C, relative density is 1.10-1.20 and reclaims ethanol to obtain concentrated solution, concentrated solution to be added water and auxiliaries becomes oral liquid.
Above-mentioned each traditional Chinese medicine powder also can be broken into powder by those skilled in the art, obtains granule, tablet or capsule according to routine techniques means.
Compared with prior art, tool of the present invention has the following advantages and progress significantly: (1) good effect.Found by a large amount of clinical practices, the medicine that the present invention relates to can not only block the formation of thrombosis, and persistent, and treating both the principal and secondary aspects of a disease has no side effect, efficacy consolidation.Further, lot of experiments research display, most cerebral thrombus patient takes medicine of the present invention and namely occurs obvious curative effects 1 course for the treatment of.(2) safety is high.Because medicine of the present invention is prepared from by adopting Chinese medicine material, toxicity is low, and patient medication is safer.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for the present invention is described, instead of limitation of the present invention, under concept thereof of the present invention, all belong to the scope of protection of present invention to the simple modifications of preparation method of the present invention.
Embodiment 1 prepares treatment cerebral thrombosis medicine oral liquid
Crude drug prescription: the Radix Astragali 10 parts, Radix Angelicae Sinensis 5 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Chuanxiong 3 parts, 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Salviae Miltiorrhizae 5 parts, Rhizoma Alismatis 5 parts, Cortex Phellodendri 3 parts, Herba Artemisiae Scopariae 8 parts, Fructus Crataegi 20 parts, Ramulus Uncariae Cum Uncis 3 parts, Scorpio 3 parts, Scolopendra 2 parts.
Preparation method: the medical material taking above-mentioned recipe quantity merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adds 95% (v/v) ethanol and makes alcohol content reach 75% (v/v), stir, hold over night, filter, under 0.08MPa, 65 DEG C of conditions, concentrating under reduced pressure becomes filtrate is 1.15g/mL to relative density when 65 DEG C, adds water and sucrose is mixed with oral liquid.
Embodiment 2 prepares the medicine oral liquid for the treatment of cerebral thrombosis
Crude drug prescription: the Radix Astragali 20 parts, Radix Angelicae Sinensis 9 parts, Radix Paeoniae Rubra 10 parts, Rhizoma Chuanxiong 6 parts, 20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Salviae Miltiorrhizae 10 parts, Rhizoma Alismatis 10 parts, Cortex Phellodendri 10 parts, Herba Artemisiae Scopariae 15 parts, Fructus Crataegi 25 parts, Ramulus Uncariae Cum Uncis 10 parts, Scorpio 5 parts, Scolopendra 4 parts.
Preparation method: the medical material taking above-mentioned recipe quantity merges, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adds 95% (v/v) ethanol and makes alcohol content reach 85% (v/v), stir, hold over night, filter, under 0.08MPa, 65 DEG C of conditions, concentrating under reduced pressure becomes filtrate is 1.15g/mL to relative density when 65 DEG C, adds water and sucrose is mixed with oral liquid.
Embodiment 3 medicine of the present invention is to the effectiveness study of cerebral thrombus patient
Chinese medicine oral liquid sample preparation: take Radix Astragali 15g, Radix Angelicae Sinensis 6g, Radix Paeoniae Rubra 5g, Rhizoma Chuanxiong 3g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12g, Radix Salviae Miltiorrhizae 9g, Rhizoma Alismatis 9g, Cortex Phellodendri 6g, Herba Artemisiae Scopariae 10g, Fructus Crataegi 23g, Ramulus Uncariae Cum Uncis 6g, Scorpio 3g, Scolopendra 3g, the medical material of above-mentioned recipe quantity is merged, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, when being evaporated to 70 DEG C at 70 DEG C, relative density is 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, hold over night, filter, filtrate is at 0.08MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.15g/mL to relative density when 65 DEG C, .
(1) physical data
The present inventor carried out clinical observation treatment to 150 routine out-patients so far in 2009, minimal ages 43, max age 78 years old.
(2) Therapeutic Method: the above-mentioned obtained oral liquid of potion every day, morning and evening service once, 6 days courses for the treatment of.
(3) efficacy assessment standard
Cure: symptom and sign disappears completely;
Effective: symptom and sign comparatively before alleviates;
Invalid: symptom and sign is front without improving with treatment.
(4) therapeutic effect:
Clinical cure 123 example, effective 27 examples, invalid 0 example, total effective rate 100%.
(5) model case:
Zhang, female, 48 years old, take action between 2009-2010 dumb, occasionally have dizzy, examined as cerebral thrombosis to hospital, hospitalize 2 months, sb.'s illness took a favorable turn, goes home to take good care of with leaving hospital, and starts to take Chinese medicine of the present invention subsequently after recurrence, after 1 course for the treatment of, symptom obviously alleviates, continue to take transference cure after 2 courses for the treatment of, continue to strengthen drug withdrawal after 1 course for the treatment of of treatment, do not recur so far.
Lee, 71 years old, there is face paralysis in 2010, through going to a doctor as cerebral thrombosis, immediately taking Chinese medicine of the present invention, transference cure after 3 courses for the treatment of in man, continues to take drug withdrawal after 2 courses for the treatment of, do not recur so far.
Found by a large amount of clinical practices, the medicine that the present invention relates to can not only be removed thrombosis and block the formation of thrombosis, and persistent, and treating both the principal and secondary aspects of a disease, has no side effect, efficacy consolidation.Further, lot of experiments research display, most cerebral thrombus patient takes medicine of the present invention and namely occurs obvious curative effects 1 course for the treatment of, stops the state of an illness to worsen further, continues to take cure rate higher.
Claims (7)
1. treat a pharmaceutical composition for cerebral thrombosis, it is characterized in that being prepared from by the Chinese crude drug of following weight portion: Radix Astragali 10-20 part, Radix Angelicae Sinensis 5-9 part, Radix Paeoniae Rubra 3-10 part, Rhizoma Chuanxiong 3-6 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10-20 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Alismatis 5-10 part, Cortex Phellodendri 3-10 part, Herba Artemisiae Scopariae 8-15 part, Fructus Crataegi 20-25 part, Ramulus Uncariae Cum Uncis 3-10 part, Scorpio 3-5 part, Scolopendra 2-4 part.
2. the pharmaceutical composition for the treatment of cerebral thrombosis as claimed in claim 1, is characterized in that being prepared from by the Chinese crude drug of following weight portion: Radix Astragali 12-18 part, Radix Angelicae Sinensis 5-8 part, Radix Paeoniae Rubra 3-8 part, Rhizoma Chuanxiong 3-5 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 11-16 part, Radix Salviae Miltiorrhizae 6-10 part, Rhizoma Alismatis 7-10 part, Cortex Phellodendri 5-10 part, Herba Artemisiae Scopariae 9-14 part, Fructus Crataegi 22-25 part, Ramulus Uncariae Cum Uncis 3-8 part, Scorpio 3-4 part, Scolopendra 2-4 part.
3. the pharmaceutical composition for the treatment of cerebral thrombosis as claimed in claim 2, is characterized in that being prepared from by the Chinese crude drug of following weight portion: Radix Astragali 14-18 part, Radix Angelicae Sinensis 5-7 part, Radix Paeoniae Rubra 3-6 part, Rhizoma Chuanxiong 3-4 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 11-14 part, Radix Salviae Miltiorrhizae 8-10 part, Rhizoma Alismatis 8-10 part, Cortex Phellodendri 5-9 part, Herba Artemisiae Scopariae 9-12 part, Fructus Crataegi 22-23 part, Ramulus Uncariae Cum Uncis 3-7 part, Scorpio 3-4 part, Scolopendra 3-4 part.
4. the pharmaceutical composition for the treatment of cerebral thrombosis as claimed in claim 3, is characterized in that being prepared from by the Chinese crude drug of following weight portion: the Radix Astragali 15 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Chuanxiong 3 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Salviae Miltiorrhizae 9 parts, Rhizoma Alismatis 9 parts, Cortex Phellodendri 6 parts, Herba Artemisiae Scopariae 10 parts, Fructus Crataegi 23 parts, Ramulus Uncariae Cum Uncis 6 parts, Scorpio 3 parts, Scolopendra 3 parts.
5. the pharmaceutical composition of the treatment cerebral thrombosis as described in as arbitrary in claim 1-4, is characterized in that: the pharmaceutical composition of described treatment cerebral thrombosis can be made into oral formulations.
6. the pharmaceutical composition for the treatment of cerebral thrombosis as claimed in claim 5, is characterized in that: described oral formulations is oral liquid, granule, tablet or capsule.
7. the application of the arbitrary described pharmaceutical composition of claim 1-4 in preparation treatment cerebral thrombosis medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410595609.8A CN104288377A (en) | 2014-10-30 | 2014-10-30 | Medicine composition for treating cerebral thrombosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410595609.8A CN104288377A (en) | 2014-10-30 | 2014-10-30 | Medicine composition for treating cerebral thrombosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104288377A true CN104288377A (en) | 2015-01-21 |
Family
ID=52308488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410595609.8A Withdrawn CN104288377A (en) | 2014-10-30 | 2014-10-30 | Medicine composition for treating cerebral thrombosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104288377A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721583A (en) * | 2015-04-06 | 2015-06-24 | 四川双鑫生物科技有限公司 | Oral medicine for treating toxic encephalitis sequela and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120735A (en) * | 2011-11-18 | 2013-05-29 | 谭建 | Medicinal composition for treating cerebral apoplexy hemiplegia |
-
2014
- 2014-10-30 CN CN201410595609.8A patent/CN104288377A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120735A (en) * | 2011-11-18 | 2013-05-29 | 谭建 | Medicinal composition for treating cerebral apoplexy hemiplegia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721583A (en) * | 2015-04-06 | 2015-06-24 | 四川双鑫生物科技有限公司 | Oral medicine for treating toxic encephalitis sequela and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104958484A (en) | traditional Chinese medicine unguent for promoting blood circulation to remove meridian obstruction and preparing method of traditional Chinese medicine unguent | |
| CN106138544A (en) | A kind of ointment treating pain and preparation method thereof using method | |
| CN103479896B (en) | Medicament for treating cerebral thrombosis and preparation method of medicament | |
| CN103007062B (en) | Chinese medicinal preparation for treating cerebral thrombosis | |
| CN104826036A (en) | Composite traditional Chinese medicine composition for treating hyperplasia of mammary glands and method for manufacturing composite traditional Chinese medicine composition | |
| CN105362711A (en) | Plaster for treating pain of bone injury and preparation method thereof | |
| CN103736069A (en) | Plaster for treating rheumatism and preparation method thereof | |
| CN103550539B (en) | Chinese medicinal composition for treating hypertension | |
| CN103393943B (en) | Traditional Chinese medicine composition for treating sequela of cerebral infarction | |
| CN105031013A (en) | Medicine for treating lumbar vertebrae bone hyperplasia and preparation method thereof | |
| CN102949571B (en) | Medicine for treating chronic osteomyelitis | |
| CN104771678A (en) | Drug for treating thrombophlebitis and preparation method thereof | |
| CN104225275A (en) | Traditional Chinese medicine composition for treating cerebral thrombosis and preparation method of composition | |
| CN104288377A (en) | Medicine composition for treating cerebral thrombosis | |
| CN103610772B (en) | The Chinese medicine for the treatment of cerebral thrombosis | |
| CN104338052A (en) | Formula of traditional Chinese medicine for treating cerebral thrombosis | |
| CN104800610A (en) | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof | |
| CN104398774A (en) | Traditional Chinese drug for treating diabetic peripheral neuropathy | |
| CN104306741A (en) | A traditional Chinese medicine formula for treating cerebral hemorrhage | |
| CN103784879A (en) | Compound traditional Chinese medicinal preparation for treating ischemic cerebrovascular diseases | |
| CN103432328B (en) | Traditional Chinese medicine formula for treating femoral head necrosis by traditional Chinese medicine fuming moxibustion therapy | |
| CN107496765A (en) | It is a kind of effectively to treat Chinese medicine composition of acute pancreatitis and preparation method thereof | |
| CN105688075A (en) | Novel oral preparation for treating stomachache and preparation method thereof | |
| CN105343582A (en) | Medicine for treating tetanus and preparation method thereof | |
| CN105362944A (en) | Traditional Chinese medicine ointment for treating orthopedics sprain and contusion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ding Ximing Inventor after: Lu Liqin Inventor before: Cui Yinfang |
|
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20150121 |