CN1042795C - 抗氧剂羟基咔唑化合物保护神经的用途及用其治疗的方法 - Google Patents

抗氧剂羟基咔唑化合物保护神经的用途及用其治疗的方法 Download PDF

Info

Publication number
CN1042795C
CN1042795C CN93120406A CN93120406A CN1042795C CN 1042795 C CN1042795 C CN 1042795C CN 93120406 A CN93120406 A CN 93120406A CN 93120406 A CN93120406 A CN 93120406A CN 1042795 C CN1042795 C CN 1042795C
Authority
CN
China
Prior art keywords
formula
carbon atoms
alkyl group
low alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93120406A
Other languages
English (en)
Chinese (zh)
Other versions
CN1098908A (zh
Inventor
F·C·巴龙尼
G·富尔斯坦
岳天立
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1098908A publication Critical patent/CN1098908A/zh
Application granted granted Critical
Publication of CN1042795C publication Critical patent/CN1042795C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN93120406A 1992-12-01 1993-12-01 抗氧剂羟基咔唑化合物保护神经的用途及用其治疗的方法 Expired - Fee Related CN1042795C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98392092A 1992-12-01 1992-12-01
US983,920 1992-12-01

Publications (2)

Publication Number Publication Date
CN1098908A CN1098908A (zh) 1995-02-22
CN1042795C true CN1042795C (zh) 1999-04-07

Family

ID=25530181

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93120406A Expired - Fee Related CN1042795C (zh) 1992-12-01 1993-12-01 抗氧剂羟基咔唑化合物保护神经的用途及用其治疗的方法

Country Status (8)

Country Link
EP (1) EP0671914A1 (enrdf_load_stackoverflow)
JP (1) JPH08503711A (enrdf_load_stackoverflow)
KR (1) KR950703950A (enrdf_load_stackoverflow)
CN (1) CN1042795C (enrdf_load_stackoverflow)
AU (1) AU673882B2 (enrdf_load_stackoverflow)
CA (1) CA2150695A1 (enrdf_load_stackoverflow)
WO (1) WO1994012178A1 (enrdf_load_stackoverflow)
ZA (1) ZA938897B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1310904C (zh) * 2001-04-23 2007-04-18 霍夫曼-拉罗奇有限公司 三环烷基异羟肟酸酯,它们的制备和它们作为细胞增殖抑制剂的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040680A1 (en) * 1996-04-29 1997-11-06 Smithkline Beecham Corporation Antioxidant compound
EP0910374A1 (de) * 1996-07-13 1999-04-28 Roche Diagnostics GmbH Topisch einsetzbare pharmazeutische formulierungen enthaltend als wirkstoff ein carbazolyl-(4)-oxy-propanolamin-derivat
US6369106B1 (en) * 1996-12-26 2002-04-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
JPH10251147A (ja) * 1997-03-06 1998-09-22 Akira Matsumori 炎症性疾患の予防・治療剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STROKE,1992,23(11) 1992.11.1 Lysko,paul G.et al."Neroprotetive effects of caredilol,a new antihyper-tew *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1310904C (zh) * 2001-04-23 2007-04-18 霍夫曼-拉罗奇有限公司 三环烷基异羟肟酸酯,它们的制备和它们作为细胞增殖抑制剂的应用

Also Published As

Publication number Publication date
CN1098908A (zh) 1995-02-22
JPH08503711A (ja) 1996-04-23
AU673882B2 (en) 1996-11-28
CA2150695A1 (en) 1994-06-09
KR950703950A (ko) 1995-11-17
ZA938897B (en) 1994-08-01
WO1994012178A1 (en) 1994-06-09
AU5732394A (en) 1994-06-22
EP0671914A4 (enrdf_load_stackoverflow) 1995-10-25
EP0671914A1 (en) 1995-09-20

Similar Documents

Publication Publication Date Title
CN1043509C (zh) 抗氧剂羟基咔唑化合物的制药用途
AU2009201065B2 (en) Use of ranolazine for the preparation of a medicament for the treatment of arrhythmias
JP3313714B2 (ja) 抗虚血薬剤
HUE034007T2 (en) Treatment of atrial fibrillation
EP1006793B1 (en) Anti-arrhythmic composition and methods of treatment
CN1042795C (zh) 抗氧剂羟基咔唑化合物保护神经的用途及用其治疗的方法
US20020019432A1 (en) Antioxidant neuroprotective use of, and method of treatment using, hydroxycarbazole compounds
EP1727545B1 (en) Use of n-piperidine derivatives for the treatment of neurodegenerative pathologies
GB2189703A (en) Vinpocetine
JP2893903B2 (ja) 虚血―再灌流障害予防、治療剤
US3904758A (en) Method of increasing wakefulness
EP0907318A1 (en) Antioxidant compound
KR20210046115A (ko) 니아신 유도체 및 이를 함유하는 약학 조성물
JP2003267871A (ja) 放射線障害予防剤
JPS61200917A (ja) ベタキソロールとニフエジピンとを含有する医薬組成物
HK1120390B (en) Use of ranolazine for the preparation of a medicament for the treatment of early afterdepolarisations (eads)

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee