CN104248476A - Simple novel anesthesia machine for experiment - Google Patents

Simple novel anesthesia machine for experiment Download PDF

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Publication number
CN104248476A
CN104248476A CN201410534309.9A CN201410534309A CN104248476A CN 104248476 A CN104248476 A CN 104248476A CN 201410534309 A CN201410534309 A CN 201410534309A CN 104248476 A CN104248476 A CN 104248476A
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CN
China
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communicated
centrifuge tube
gas flowmeter
anesthesia
anesthetic
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CN201410534309.9A
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Chinese (zh)
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CN104248476B (en
Inventor
王杰
刘泽源
徐富强
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中国科学院武汉物理与数学研究所
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Abstract

The invention discloses a simple novel anesthesia machine for an experiment. The simple novel anesthesia machine comprises an oxygenation pump, and further comprises a centrifugal tube with a liquid anesthetic, wherein the oxygenation pump is respectively communicated with a first gas flowmeter and a second gas flowmeter; the first gas flowmeter is communicated with the centrifugal tube through a centrifugal tube gas-intake duct; the second gas flowmeter is communicated with a tee joint; the tee joint is communicated with the centrifugal tube through a centrifugal tube discharge duct; the tee joint is further communicated with an anesthesia induction box or a respiration anesthesia box through an anesthesia duct. The simple novel anesthesia machine for the experiment disclosed by the invention has the advantages of being high in structural strength, stable in structure, safe, reliable, easy to control of concentration, cheap, fine and the like.

Description

A kind of simple and easy Novel experimental anesthetic machine

Technical field

The present invention relates to animal experiment device capable field, more specifically relate to a kind of simple and easy Novel experimental anesthetic machine, be applicable to the anesthesia of meiofauna.

Background technology

The operation principle of zoopery anesthetic gas machine is incorporated in anesthesia bottle by mechanical circuit by air-flow, and then impel anesthetis to volatilize, the air-flow carrying anesthetic gases imports to animal nasal cavity, whole body is arrived everywhere finally by the respiratory system of animal and blood circulation, thus directly inhibitory action is carried out to central nervous system, produce the effect of general anesthesia.Anesthetic gas machine belongs to semi open model equipment, can be divided into several part according to its operation principle: air supply system, anesthetis volatilization system, induction of anesthesia and maintenance system, residual gas scavenging system etc.

The anesthetic machine that market is sold is used for field of medicaments, and owing to being applied to human body, design is general more accurate, and complex structure, corresponding cost is higher.Even if also cost is higher to be applied to the anesthetic machine of zooscopy, not easily promote practicality.But along with biological development, the application of animal in biological experiment is more and more extensive, therefore, easy, quick, safe and the anesthetic machine of effective anesthetized animal can also become a problem demanding prompt solution.Existing Medical anesthetic machine and commercial animal anesthetic machine, the cost of its costliness brings unnecessary waste.Some laboratory design anesthetic machine of oneself, but effect is poor, and residual gas is revealed comparatively serious, to the health of experimenter unfavorable.Given this, applicant devises this Simple And Practical type anesthetic machine for laboratory animal, its simplicity of design, efficient, and structure is simplified, easy and simple to handle, effectively can anaesthetize the such as minitype animal experiment such as rat, mice.This anesthetic machine is with low cost, and reliability is high, and concentration is adjustable, easy to carry, can be widely used in biology laboratory.

In addition, consider the health of experimenter, specially with the addition of residual gas when designing and eliminate system, can prevent residual gas from entering laboratory, and then experimenter is effectively protected.

Summary of the invention

The object of the invention is the problems referred to above being to exist for prior art, a kind of simple and easy Novel experimental anesthetic machine is provided, reduces operation easier, reduce the cost of Animal Anesthesia, and have residual gas elimination system.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

A kind of simple and easy Novel experimental anesthetic machine, comprise oxygen increasing pump, also comprise the centrifuge tube being provided with liquid anaesthetic agent, oxygen increasing pump is communicated with the second gas flowmeter with the first gas flowmeter respectively, first gas flowmeter is communicated with centrifuge tube by centrifuge tube air induction conduit, second gas flowmeter is communicated with threeway, and threeway is communicated with centrifuge tube by centrifuge tube outtake tube, and threeway is also communicated with induction of anesthesia box by anesthetic tube.

Induction of anesthesia box as above is transparent sealing plastic lunch box.

A kind of simple and easy Novel experimental anesthetic machine, also comprises the breathing be communicated with anesthetic tube and anaesthetizes box, breathes on anesthesia box and offers pneumostome.

A kind of simple and easy Novel experimental anesthetic machine, also comprises vacuum pump, and vacuum pump is anaesthetized box with breathing and is communicated with.

Centrifuge tube air induction conduit as above extends to below the liquid level of liquid anaesthetic agent, and described centrifuge tube outtake tube extends to the ullage of liquid anaesthetic agent.

The present invention compared with prior art, has the following advantages:

1, small-sized anesthetic machine simplicity of design, easy to operate and be easy to carry about with one.In development process, cast out heavy high-pressure nitrogen bottle and high-pressure oxygen cylinder etc., only used small-sized oxygen increasing pump can realize air-flow supply.Any experimenter gets final product proper operation after simple study.This equipment dependability is high, can promote the use of.

2, anesthetis concentration easily regulates, and the concentration of anesthetic gases mixes generation according to a certain percentage by anesthetic gases and air.Therefore, the air-flow monitoring of this small-sized anesthetic machine is completed by two gas flowmeters (the first gas flowmeter and the second gas flowmeter) cooperation control, and then anesthetis concentration in effective adjustments of gas, thus effectively controls toy depth of anesthesia.This anesthetic machine controls gas flow by mass air flow sensor, simply efficiently, saves medicine.This anesthetic machine both can carry out rapid induction anesthesia (<1min) to animal, also can maintain low anesthetis concentration and make animal long-time (>2h) keep narcotism.

3, vacuum pump can be utilized by tail gas guide to outdoor, avoid it to spill in laboratory, and then reach the object of Protection personnel.

4, selected equipment cost is low, and total price, far below business machine on market, should be generalized in biotic experiment.In addition, all systems are all inner at a cuboid acrylic board case, are easy to carry and use; Adjusting knob is installed on outer wall, is beneficial to adjustment.

The present invention has These characteristics, has realized the object that cost is low, structure is simple, operation is easy, efficiency is high, is carry out zooperal ideal equipment.

Accompanying drawing explanation

Fig. 1 is the structural representation of the first embodiment of the present invention.

Fig. 2 is the structural representation of the second embodiment of the present invention.

In figure: 1-anesthetic machine shell; 2-oxygen increasing pump; 3-first gas flowmeter; 4-second gas flowmeter; 5-anesthetis; 6-centrifuge tube (50ml centrifuge tube can be selected); 7-centrifuge tube air inlet; 8-centrifuge tube gas outlet; 9-threeway; 10-induction of anesthesia box; 11-breathes anesthesia box; 12-vacuum pump; 13-is dull and stereotyped.

Detailed description of the invention

Below in conjunction with accompanying drawing, technical scheme of the present invention is described in further detail.

Embodiment 1

As shown in Figure 1 and 2,

One, air-flow supply:

Air-flow supply of the present invention all comes from oxygen increasing pump 2.Oxygen increasing pump 2 has two outlets, and one of them outlet imports the first gas flowmeter 3(250mL/min by conduit), regulate flow velocity, can produce the air draught of certain flow rate, this air-flow imports centrifuge tube 6 through centrifuge tube air induction conduit, can produce anesthetic gases; Another outlet then by tubes connection to the second gas flowmeter 4(1L/min), regulate flow velocity, the air draught of certain flow rate can be produced, mix with the anesthetic gases finally produced by centrifuge tube gas outlet 8, and then can anesthesia gas concentration be diluted.This place uses the gas flowmeter of two kinds of flow velocitys, and wherein the first gas flowmeter 3 can be finely tuned gas flow rate comparatively easily, thus is convenient to the generation concentration effectively controlling anesthetic gases; The introducing of the second gas flowmeter 4, then after provide enough oxygen for toy, plays the effect reducing anesthesia gas concentration fast.Anesthetic machine shell 1 can select cuboid acrylic board case, oxygen increasing pump 2, first gas flowmeter 3, second gas flowmeter 4, centrifuge tube 6, centrifuge tube air inlet 7 are all arranged in anesthetic machine shell 1, the adjusting knob of the first gas flowmeter 3 and the second gas flowmeter 4 is arranged on anesthetic machine shell 1, and the mouth of pipe of centrifuge tube 6 stretches out anesthetic machine shell 1.

Two, induction of anesthesia:

Induction of anesthesia box 10 can select common transparent sealing plastic lunch box, not only can observe the narcotism of animal easily, and is very easy to obtain.Induction of anesthesia box 10 is not only cheaply a lot of than commercialization induction box, and easily finds the succedaneum of various volume size, thus is applicable to the animal of different building shape.In use procedure, open an osculum in side and top.

Liquid anaesthetic agent (such as isoflurane, halothane) is poured into 50ml centrifuge tube from top, lid sealing gas of screwing on.For the ease of adding liquid anaesthetic agent at any time, do not affect formation and the release of anesthetic gases, centrifuge tube 6 has to pass through simple reformation simultaneously, namely establishes two and catheter outer diameter aperture of the same size newly in centrifuge tube 6 side, one of them is centrifuge tube air inlet, and another one is centrifuge tube gas outlet.Wherein, centrifuge tube air inlet is directly connected to the gas outlet of the first gas flowmeter 3 by centrifuge tube air induction conduit.For the ease of producing the anesthetic gases of high concentration, the outlet of the centrifuge tube air induction conduit in centrifuge tube 6 must extend to the bottom of centrifuge tube 6 or directly contact bottom centrifuge tube; And the air flow inlet place of the centrifuge tube outtake tube of centrifuge tube outlet must on the liquid level of liquid anaesthetic agent.Meanwhile, the junction of centrifuge tube air induction conduit, centrifuge tube outtake tube and centrifuge tube needs to seal with glass cement.The anesthetic gases produced is by admixed together by threeway 9 for the air of deriving with the second gas flowmeter 4, and mist directly imports induction of anesthesia box by anesthetic tube.

Open oxygen increasing pump 2, regulate the uninterrupted of the first gas flowmeter 3 and the second gas flowmeter 4, thus control narcotic concentration.In animal induction anaesthesia process, need the anesthetic gases using high concentration, flow velocity by the first gas flowmeter 3 tunes up, produce the initial anesthetic gas of higher concentration, the flow velocity of the second gas flowmeter 4 is reduced as far as possible simultaneously, and then produce the air of a small amount of dilution anesthetic gases, thus produce high concentration anesthetic gases.Reduce the concentration of anesthetic gases if necessary, then need reverse operating, namely reduce the flow velocity of the first gas flowmeter 3, improve the flow velocity of the second gas flowmeter 4.

Export through centrifuge tube gas outlet 8 after anesthetis volatilization, and the T-shaped interface point of threeway is transported to by conduit, mix with the air inputted by the second gas flowmeter 4, then arrive induction of anesthesia box induced anesthesia (anesthesia duration of test rat and mouse is all less than 1min) is carried out to toy.

Three, anesthesia maintenance

After Animal Anesthesia, transfer on dull and stereotyped 13, breathing anesthesia box is communicated with anesthetic tube, animal mouth and nose are placed in the breathing anesthesia mouth place of breathing anesthesia box, maintain narcotism;

Regulate the ratio of the first gas flowmeter 3 and the second gas flowmeter 4, reduce anesthetis concentration, thus long-term efficient maintenance Animal Anesthesia state (the continuous narcosis time of test rat and mouse can be greater than 2h);

For Protective strategy personnel, residual gas is discharged outside laboratory through pipeline by vacuum pump 12 sucking-off.

During use, if anesthetis total amount is too low, then closes oxygen increasing pump 2, turning on centrifuge tube 6, add anesthetis, screw a lid on, again opening the power supply for controlling oxygen increasing pump 2 and vacuum pump 12.Convenient and easy, and do not affect whole system.Close anesthetic machine by powered-down.

Specific embodiment described herein is only to the explanation for example of the present invention's spirit.Those skilled in the art can make various amendment or supplement or adopt similar mode to substitute to described specific embodiment, but can't depart from spirit of the present invention or surmount the scope that appended claims defines.

Claims (5)

1. a simple and easy Novel experimental anesthetic machine, comprise oxygen increasing pump (2), it is characterized in that, also comprise the centrifuge tube (6) being provided with liquid anaesthetic agent, oxygen increasing pump (2) is communicated with the second gas flowmeter (4) with the first gas flowmeter (3) respectively, first gas flowmeter (3) is communicated with centrifuge tube (6) by centrifuge tube air induction conduit, second gas flowmeter (4) is communicated with threeway (9), threeway (9) is communicated with centrifuge tube (6) by centrifuge tube outtake tube, and threeway is also communicated with induction of anesthesia box (10) by anesthetic tube.
2. the simple and easy Novel experimental anesthetic machine of one according to claim 1, is characterized in that, described induction of anesthesia box (10) is transparent sealing plastic lunch box.
3. the simple and easy Novel experimental anesthetic machine of one according to claim 1, is characterized in that, also comprises the breathing be communicated with anesthetic tube and anaesthetizes box (11), breathes in anesthesia box (11) and offers pneumostome.
4. the simple and easy Novel experimental anesthetic machine of one according to claim 2, is characterized in that, also comprises vacuum pump (12), and vacuum pump (12) is anaesthetized box (11) with breathing and is communicated with.
5. the simple and easy Novel experimental anesthetic machine of one according to claim 1, is characterized in that, described centrifuge tube air induction conduit extends to below the liquid level of liquid anaesthetic agent, and described centrifuge tube outtake tube extends to the ullage of liquid anaesthetic agent.
CN201410534309.9A 2014-10-10 2014-10-10 A kind of simple and easy Novel experimental anesthetic machine CN104248476B (en)

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CN104248476B CN104248476B (en) 2016-06-22

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060048779A1 (en) * 2004-08-18 2006-03-09 Rounbehler David R Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
CN201171730Y (en) * 2008-03-11 2008-12-31 上海睿智化学研究有限公司 Gas anesthesia device
JP2009011505A (en) * 2007-07-03 2009-01-22 Sumika Technoservice Kk Simple inhalation anesthesia device and multistage type simple inhalation anesthesia apparatus equipped with the same
CN101953720A (en) * 2010-11-01 2011-01-26 同济大学 Small-sized insect anesthesia apparatus
CN102138834A (en) * 2011-03-01 2011-08-03 西安交通大学医学院第一附属医院 Anesthesia device for animal experiment
CN102743238A (en) * 2012-07-02 2012-10-24 温州医学院附属第二医院 Method for managing experimental animal respiration
CN203506929U (en) * 2013-10-16 2014-04-02 中国人民解放军第二军医大学 Simple respirator of naked mole rat

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060048779A1 (en) * 2004-08-18 2006-03-09 Rounbehler David R Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
JP2009011505A (en) * 2007-07-03 2009-01-22 Sumika Technoservice Kk Simple inhalation anesthesia device and multistage type simple inhalation anesthesia apparatus equipped with the same
CN201171730Y (en) * 2008-03-11 2008-12-31 上海睿智化学研究有限公司 Gas anesthesia device
CN101953720A (en) * 2010-11-01 2011-01-26 同济大学 Small-sized insect anesthesia apparatus
CN102138834A (en) * 2011-03-01 2011-08-03 西安交通大学医学院第一附属医院 Anesthesia device for animal experiment
CN102743238A (en) * 2012-07-02 2012-10-24 温州医学院附属第二医院 Method for managing experimental animal respiration
CN203506929U (en) * 2013-10-16 2014-04-02 中国人民解放军第二军医大学 Simple respirator of naked mole rat

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