CN104189200A - Cream for treating eczema, and preparation method thereof - Google Patents
Cream for treating eczema, and preparation method thereof Download PDFInfo
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- CN104189200A CN104189200A CN201410501172.7A CN201410501172A CN104189200A CN 104189200 A CN104189200 A CN 104189200A CN 201410501172 A CN201410501172 A CN 201410501172A CN 104189200 A CN104189200 A CN 104189200A
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Abstract
The invention provides a cream for treating eczema, and a preparation method thereof. The cream comprises the following components in parts by mass: 5-15 parts of root-bark of tree peony, 5-15 parts of amur corktree bark, 5-15 parts of lithospermum, 3-12 parts of patycodon grandiflorum, 3-12 parts of red paeony roots, 30-50 parts of glycerinum and 500-1000 parts of an oil-in-water type cream matrix. The cream for treating the eczema provided by the invention has the efficacies of clearing away heat and detoxifying, eliminating dampness and relieving itching, and can be used for effectively treating acute or chronic eczema, neurodermatitis, contact dermatitis, allergic dermatitis and folliculitis after being smeared at affected parts; the cream can be suitable for infants and sensitive skin crowds, has no any side effect, has an obvious curative effect, has no sequela and is convenient and safe to use.
Description
Technical field
The present invention relates to a kind of medicinal cream, be specifically related to a kind of emulsifiable paste for the treatment of eczema and preparation method thereof, belong to biological medicine technology field.
Background technology
Eczema is the inflammatory skin disease of a kind of common epidermis being caused by multiple internal and external factor and high dermis.There is the features such as symmetry, exudative, itching skin disease, pleomorphism and recurrent.Clinical manifestation is that skin lesion is pleomorphism, and taking erythema, pimple, papulovesicle as main, erythra central authorities obviously, scatter gradually towards periphery, indefinite border, and diffusivity, has the tendency of oozing out.
Infantile eczema is called tire leprosy, infantile eczema, erythroderma of newborn, abnormal red skin of infant etc., a multitude of names on traditional Chinese medical science ancient literature.In " doctor ancestor takes mirror surgery heart method gist ", describe comparatively definitely: an impetigo glabella that starts, in tire, heat in blood wind-engaging twines, the wet excessive water of the dry white scales of itching, thermoae blush class erysipelas.Add: the raw baby of this card crown, or raw tip of the brow, have another name called infantile eczema.The white scales of having itched, shape is as tinea scabies, by heat in blood in tire.The wind-engaging of taking to the greenwood is touching, and this is dry abnormal pigmentary deposit on the skin.Have misuse to scald, skin plays foxtail millet, and pruritus is immoderate. yellow fluid contamination, prolong and all over, wet clonic convulsion.Infantile eczema is one of Pediatrics Department commonly encountered diseases frequently-occurring disease.With local erythema, pimple, vesicle, have that juice oozes out, rotten to the corn, pruritus and repeatedly outbreak be its main feature.The origin cause of formation of primary disease is many by the pungent scorching thing of wet nurse's surfeit, by the transmission of breast milk, causes baby to be stranded by damp and hot, transformation failure of spleen.More double baby is the body of young sun, deficiency of primordial QI, damp and hot heresy is attacked in space between skin and muscles, the inside and outside damp and hot knot of fighting mutually, primary disease.If hold concurrently mutually with ailment said due to cold or exposure damp and hot, benefaction number becomes, and pruritus is obvious, rises one after another; If damp and hot fire-transformation, rising body fluid, shows as again the flowing water that festers, and affected part skin and flesh is scarlet.
At present, if the drug main for the treatment of acute eczema is selected appropriate dosage forms and medicine according to skin lesion situation, as tacrolimus ointment, pimecrolimus ointment etc., there is the deficiencies such as not obvious, the easy recurrence of curative effect, toxic and side effects are large.But eczema ointment on the market seldom can be used for baby, or the curative effect again that baby can be suitable for is bad, causes the disease time long, also can cause baby's inappetence, the problem such as do not have enough sleep.
Summary of the invention
Can not be suitable for the problem such as baby or weak curative effect for solving eczema ointment of the prior art, the invention provides a kind of emulsifiable paste for the treatment of eczema and preparation method thereof.
The present invention realizes by following technical proposal: a kind of emulsifiable paste for the treatment of eczema, is made up of the component of following mass parts:
5～15 parts of Cortex Moutans,
5～15 parts of Cortex Phellodendris,
5～15 parts of Radix Arnebiae (Radix Lithospermi)s,
3～12 parts of Radix Platycodoniss,
3～12 parts of Radix Paeoniae Rubra,
30～50 parts of glycerol,
500～1000 parts of oil-in-water type emulsifiable paste matrixes.
Wherein, Cortex Moutan: have another name called Cortex Moutan, nature and flavor: cold, hardship, cool, be slightly cold; Return: the heart, liver, kidney, lung meridian; Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.Cortex Phellodendri: nature and flavor: bitter, cold; Gui Jing: kidney, bladder, large intestine channel; Effect: heat-clearing and toxic substances removing; Heat clearing and damp drying.Radix Arnebiae (Radix Lithospermi): nature and flavor: cold, sweet, salty; Gui Jing: the heart, Liver Channel; Effect: removing heat from blood, invigorate blood circulation, removing toxic substances rash.Radix Platycodonis: nature and flavor: bitter, pungent, slightly warm in nature; Gui Jing: lung meridian; Effect
:lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Radix Paeoniae Rubra: nature and flavor: hardship, is slightly cold; Gui Jing: Liver Channel; Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.Each composition of the present invention is national corporation of medical herbs commercially available prod.
The invention provides the pharmacological action of medicine: Cortex Moutan has effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, for sending out speckle, carbuncle sore tumefacting virus.Cortex Phellodendri tool heat-clearing and toxic substances removing; The effect of heat clearing and damp drying, for skin sore; Skin eczema.Radix Arnebiae (Radix Lithospermi) has removing heat from blood, invigorates blood circulation, and the effect of removing toxic substances rash,, measles without adequate eruption black for macule purple, skin infection, eczema, burn.Radix Platycodonis has lung qi dispersing, eliminates the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, the effect such as foster the spirit of nobility, for antiinflammatory, calmness, analgesia and antipyretic.Radix Paeoniae Rubra has effect of clearing away heat and cooling blood, eliminating stasis to stop pain, for carbuncle sore tumefacting virus.Each composition of the present invention is national corporation of medical herbs commercially available prod.
The emulsifiable paste for the treatment of eczema provided by the invention, makes through the following step:
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
5～15 parts of Cortex Moutans,
5～15 parts of Cortex Phellodendris,
5～15 parts of Radix Arnebiae (Radix Lithospermi)s,
3～12 parts of Radix Platycodoniss,
3～12 parts of Radix Paeoniae Rubra,
30～50 parts of glycerol,
500～1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
The present invention possesses following advantages and effect: the emulsifiable paste for the treatment of eczema provided by the invention has heat-clearing and toxic substances removing, and effect of dampness removing to stop itchin can effectively be treated acute and chronic eczema, neurodermatitis, contact dermatitis, allergic dermatitis, folliculitis by affected part of exterior coating.And the present invention can be applicable to infant and sensitivity skin quality crowd, without any side effects, evident in efficacy, no sequel is easy to use, safety.
Detailed description of the invention
Below by embodiment, the present invention will be further described.
Embodiment 1
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
10 parts of Cortex Moutans,
5 parts of Cortex Phellodendris,
5 parts of Radix Arnebiae (Radix Lithospermi)s,
6 parts of Radix Platycodoniss,
6 parts of Radix Paeoniae Rubra,
50 parts of glycerol,
1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 2
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
15 parts of Cortex Moutans,
8 parts of Cortex Phellodendris,
10 parts of Radix Arnebiae (Radix Lithospermi)s,
12 parts of Radix Platycodoniss,
3 parts of Radix Paeoniae Rubra,
30 parts of glycerol,
800 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 3
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
5 parts of Cortex Moutans,
15 parts of Cortex Phellodendris,
12 parts of Radix Arnebiae (Radix Lithospermi)s,
3 parts of Radix Platycodoniss,
12 parts of Radix Paeoniae Rubra,
40 parts of glycerol,
500 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 4
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
12 parts of Cortex Moutans,
12 parts of Cortex Phellodendris,
15 parts of Radix Arnebiae (Radix Lithospermi)s,
9 parts of Radix Platycodoniss,
6 parts of Radix Paeoniae Rubra,
50 parts of glycerol,
1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 5
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
11 parts of Cortex Moutans,
9 parts of Cortex Phellodendris,
13 parts of Radix Arnebiae (Radix Lithospermi)s,
10 parts of Radix Platycodoniss,
11 parts of Radix Paeoniae Rubra,
40 parts of glycerol,
1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 6
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
7 parts of Cortex Moutans,
6 parts of Cortex Phellodendris,
14 parts of Radix Arnebiae (Radix Lithospermi)s,
5 parts of Radix Platycodoniss,
5 parts of Radix Paeoniae Rubra,
30 parts of glycerol,
500 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
The emulsifiable paste of described embodiment gained treatment eczema is lividus emulsifiable paste.Differentiate through following method:
(1) get the about 10g of this product, add ethanol 30mL, supersound process 30 minutes, lets cool, and puts in ice bath approximately 30 minutes, filter, and filtrate evaporate to dryness, residue lets cool, and uses 1mL dissolve with ethanol, as need testing solution.Separately get Shikonin reference substance, add ethanol and make the solution of every 1mL containing 1mg.Test according to thin layer chromatography (annex VI B of Chinese Pharmacopoeia), draw the each 10 μ L of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, taking the solution of toluene-ethyl acetate-formic acid (15:1:0.1) as developing solvent, launch, take out, dry, in test sample chromatograph, with reference substance chromatograph relevant position on the speckle of aobvious same color.
(2) get the about 10g of this product, add dehydrated alcohol 30mL, in water-bath, heating makes to dissolve, and lets cool, and puts in ice bath approximately 30 minutes, filters, and gets filtrate and is concentrated into 5mL, adds 2g active carbon fully to stir, and filters, and gets filtrate as need testing solution.Separately get paeonol reference substance, add acetone and make the solution of every 1ml containing 1mg, product solution in contrast.Test according to thin layer chromatography (two annex V B of Chinese Pharmacopoeia), draw the each 10 μ L of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, taking the solution of cyclohexane extraction-ethyl acetate-glacial acetic acid (4:1:0.1) as developing solvent, launch, take out, dry, spray is with 2% vanillin ethanol solution of sulfuric acid (1 → 10) solution, and 105 DEG C to be heated to speckle colour developing clear, in test sample chromatograph, then with reference substance chromatograph relevant position on the speckle of aobvious same color.
The emulsifiable paste of gained treatment eczema meets the relevant every regulation (annex I R of Chinese Pharmacopoeia version in 2010) under ointment item.
Get the emulsifiable paste of above-described embodiment gained treatment eczema, for following clinical treatment:
One, treatment target
Two lower limb pimples, companion itches, and is diagnosed as 20 examples (age: 16～40 years old) of eczema; Waist and belly erythema, pimple, is diagnosed as 20 examples (age: 16～50 years old) of urticaria; Face red spot, pimple, the whole body is dispersed in erythema, is diagnosed as 30 examples (age: 1 monthly age～8 year old) of eczema; Neck side, napex, forehead pruritus, be lichenization, is diagnosed as 20 examples (age: 18～30 years old) of neurodermatitis; Acneform eruptions, desquamation erythema, be diagnosed as 10 examples (age: 13～20 years old) of contact dermatitis; Skin pruritus, little red pimple, erythema that a little is scattered, allergic constitution, is diagnosed as 30 examples (age: 10～40 years old) of allergic dermatitis; Red pimple, its center hairiness is sent out and is run through, and is diagnosed as 10 examples (age: 20～30 years old) of folliculitis.
Above-mentioned all kinds of cases are divided equally at random for treatment group and each 70 examples of matched group.
Two, usage
Treatment group is coated with the emulsifiable paste of above-described embodiment gained treatment eczema outside affected part, and one for several times, is even coated with 5 and observes.
In matched group, adult and old man are coated with commercial Piyanping ointment outside affected part, and the Rhizoma Atractylodis of infant use equal portions and Cortex Phellodendri are dried levigation and join vegetable oil and be coated with outside affected part, and one for several times, is even coated with 5 and observes.
Three, result
The emulsifiable paste clinical therapeutic efficacy for the treatment of eczema provided by the invention: obvious effective rate reaches 100%, reaches 96% to two lower limb pimples, the companion's person of itching eczema cure rate, and 85% above patient's first day erythema weakens, and within the 3rd day, fully recovers; Waist and belly erythema, pimple person's urticaria cure rate reach 92%, and 75% above patient's first day erythema weakens, and within second day, fully recover; Face red spot, pimple, the whole body are dispersed in erythema person's eczema cure rate and reach 99%, and 80% above patient's first day erythema disappear, and within second day, fully recover, and have 15% patient to smear and fully recover for one day; Neurodermatitis person cure rate reaches 86%; Contact dermatitis person's cure rate reaches 93%; Allergic dermatitis person's cure rate reaches 98%; Folliculitis person's cure rate reaches 83%.
And matched group is 68% to two lower limb pimples, the companion person of itching eczema effective percentage; Waist and belly erythema, pimple person's urticaria effective percentage are 79%; It is 70% that face red spot, pimple, the whole body are dispersed in erythema person's eczema effective percentage; Neurodermatitis person effective percentage is 81%; Contact dermatitis person's effective percentage is 77%; Allergic dermatitis person's effective percentage is 65%; Folliculitis effective percentage is 20%.
Four, conclusion
The compound preparation that the emulsifiable paste for the treatment of eczema provided by the invention is made up of Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra etc., has significant curative effect to acute and chronic eczema, neurodermatitis, contact dermatitis, allergic dermatitis, folliculitis, and its effect is better than matched group.
The advantage such as effective in cure good, the application safety of the emulsifiable paste of this treatment eczema, toxic and side effects are little, prepared constant product quality, easy to use, be more suitable in clinical application, and can be applicable to infant and sensitivity skin quality crowd, without any side effects, evident in efficacy, no sequel, safety.
Claims (2)
1. treat an emulsifiable paste for eczema, it is characterized in that being formed by the component of following mass parts:
5～15 parts of Cortex Moutans,
5～15 parts of Cortex Phellodendris,
5～15 parts of Radix Arnebiae (Radix Lithospermi)s,
3～12 parts of Radix Platycodoniss,
3～12 parts of Radix Paeoniae Rubra,
30～50 parts of glycerol,
500～1000 parts of oil-in-water type emulsifiable paste matrixes.
2. treat a preparation method for the emulsifiable paste of eczema, it is characterized in that through following each step:
(1) dry after Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
5～15 parts of Cortex Moutans,
5～15 parts of Cortex Phellodendris,
5～15 parts of Radix Arnebiae (Radix Lithospermi)s,
3～12 parts of Radix Platycodoniss,
3～12 parts of Radix Paeoniae Rubra,
30～50 parts of glycerol,
500～1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of above-mentioned Cortex Moutan, Cortex Phellodendri, Radix Arnebiae (Radix Lithospermi), Radix Platycodonis, Radix Paeoniae Rubra, add glycerol to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343340A (en) * | 2015-11-26 | 2016-02-24 | 姜义祥 | Eczema treatment emulsion and preparation method thereof |
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| CN101991686A (en) * | 2009-08-13 | 2011-03-30 | 蔡保君 | Oral Chinese medicine formula for treating eczema |
| CN102178874A (en) * | 2010-12-14 | 2011-09-14 | 史志辉 | Preparation method of Chinese medicinal tablet for treating skin diseases |
| CN103830639A (en) * | 2014-02-28 | 2014-06-04 | 牛良信 | Medicament for treating eczema and preparation method thereof |
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- 2014-09-26 CN CN201410501172.7A patent/CN104189200B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101991686A (en) * | 2009-08-13 | 2011-03-30 | 蔡保君 | Oral Chinese medicine formula for treating eczema |
| CN102178874A (en) * | 2010-12-14 | 2011-09-14 | 史志辉 | Preparation method of Chinese medicinal tablet for treating skin diseases |
| CN103830639A (en) * | 2014-02-28 | 2014-06-04 | 牛良信 | Medicament for treating eczema and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343340A (en) * | 2015-11-26 | 2016-02-24 | 姜义祥 | Eczema treatment emulsion and preparation method thereof |
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