CN104177836A - Medical silicon rubber formula and preparation method thereof - Google Patents
Medical silicon rubber formula and preparation method thereof Download PDFInfo
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- CN104177836A CN104177836A CN201410348527.3A CN201410348527A CN104177836A CN 104177836 A CN104177836 A CN 104177836A CN 201410348527 A CN201410348527 A CN 201410348527A CN 104177836 A CN104177836 A CN 104177836A
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Abstract
The invention discloses a medical silicon rubber formula and a preparation method thereof, relating to the technical field of medical rubber processing. The medical silicon rubber is prepared from the following raw materials in parts by mass: 80-100 parts of methylvinyl silicone rubber, 10-15 parts of polypropylene, 8-12 parts of sodium carboxymethyl starch, 5-8 parts of gelatin, 4-8 parts of octamethylcyclotetrasilazane, 2-5 parts of dioctyl phthalate, 3-7 parts of lactic acid, 2-5 parts of hydrogen-containing silicon oil, 1-4 parts of accelerator TMTD (tetramethyl thiuram disulfide), 1-2.5 parts of dicumyl peroxide, 3-5 parts of zinc oxide, 1-3 parts of stearic acid, 0.5-1.5 parts of microcrystalline wax, 1-2 parts of silica white and 2-5 parts of antioxidant. The formula has the advantages of novel design, accessible raw materials and simple production technique; and the prepared product has the advantages of higher chemical stability, no irritation, high safety, heat resistance, aging resistance and excellent mechanical properties.
Description
Technical field:
The present invention relates to medical grade rubber processing technique field, be specifically related to a kind of medical grade silicon rubber formula and preparation method thereof.
Background technology:
Along with social development, the rubber item kind that is applied to medicine and hygiene fields is more and more, as various flask for medicinal preparations plugs, piston, injection sealant sealing, flexible pipe, conduit, medical air cushion, antiseptic rubber medical gloves, baby nipple, tube for blood transfusion,latex etc. for asepsis injector.Desirable druggist rubber sundries not only needs to have good physicals, also must guarantee nontoxic and have in unreactiveness, particularly body rubber item should have not pathogenic, do not damage adjacent tissue, do not cause allergy, the feature such as aging resistance is good.
Traditional druggist rubber sundries is under high temperature, condition of high voltage, and its vulcanization system easily produces and pollutes human body, the exudate of medicament, volatile matter, thereby is difficult to the druggist rubber sundries that preparation meets medicine extra best best standard.Existing druggist rubber sundries and preparation method thereof, its complex technical process, the product feature of environmental protection is poor, and safety in utilization is not strong, and work-ing life is lower.
Summary of the invention:
Technical problem to be solved by this invention is to provide that a kind of technique is simple, the medical grade silicon rubber formula of safety and environmental protection, long service life and preparation method thereof.
Technical problem to be solved by this invention adopts following technical scheme to realize:
A medical grade silicon rubber formula, by the raw material of following mass fraction, made:
Methyl vinyl silicone rubber 80-100 part, polypropylene 10-15 part, sodium starch glycolate 8-12 part, gelatin 5-8 part, octamethylcyclotetrasilazane 4-8 part, dioctyl phthalate (DOP) 2-5 part, lactic acid 3-7 part, containing hydrogen silicone oil 2-5 part, Vulcanization accelerator TMTD 1-4 part, dicumyl peroxide 1-2.5 part, zinc oxide 3-5 part, stearic acid 1-3 part, Microcrystalline Wax 0.5-1.5 part, white carbon black 1-2 part, oxidation inhibitor 2-5 part.
Described dioctyl phthalate (DOP) is medical grade.
Described oxidation inhibitor is comprised of antioxidant 1010 and antioxidant 1076, and ratio is between the two 1:1.
A preparation method for medical grade silicon rubber, comprises the following steps:
(1) first methyl vinyl silicone rubber, polypropylene are joined to rubber mixing machine bag roller, then add sodium starch glycolate, gelatin, octamethylcyclotetrasilazane, dioctyl phthalate (DOP), lactic acid, Vulcanization accelerator TMTD, dicumyl peroxide, zinc oxide, thin-pass 5 times, lower, heat-treat;
(2), by the back mixing on rubber mixing machine of the sizing material after thermal treatment, clot, lower obtain rubber unvulcanizate;
(3) in rubber unvulcanizate, add containing hydrogen silicone oil, oxidation inhibitor, stearic acid, Microcrystalline Wax, white carbon black, after fully mixing, blank is stand-by;
(4) with Rubber Extruder, material is extruded, through hot-air vulcanization moulding, curing temperature is 150-160 ℃.
The invention has the beneficial effects as follows: formulating of recipe of the present invention is novel, raw material is easy to get, production technique is simple, and made product has higher chemical stability, nonirritant, safe, heat-resisting, anti-aging, and has good mechanical property.
Embodiment:
For technique means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
Medical grade silicon rubber formula of the present invention is made by the raw material of following mass fraction:
80 parts of methyl vinyl silicone rubbers, 10 parts of polypropylene, 8 parts of sodium starch glycolatees, 5 parts, gelatin, 4 parts of octamethylcyclotetrasilazanes, 2 parts of dioctyl phthalate (DOP)s, 3 parts of lactic acid, 2 parts of containing hydrogen silicone oils, 1 part of Vulcanization accelerator TMTD, 1 part of dicumyl peroxide, 3 parts, zinc oxide, 1 part of stearic acid, 0.5 part of Microcrystalline Wax, 1 part of white carbon black, 2 parts, oxidation inhibitor.
Embodiment 2
Medical grade silicon rubber formula of the present invention is made by the raw material of following mass fraction:
90 parts of methyl vinyl silicone rubbers, 12 parts of polypropylene, 10 parts of sodium starch glycolatees, 7 parts, gelatin, 6 parts of octamethylcyclotetrasilazanes, 3 parts of dioctyl phthalate (DOP)s, 5 parts of lactic acid, 3 parts of containing hydrogen silicone oils, 2 parts of Vulcanization accelerator TMTDs, 2 parts of dicumyl peroxides, 4 parts, zinc oxide, 2 parts of stearic acid, 1 part of Microcrystalline Wax, 1.5 parts of white carbon blacks, 3 parts, oxidation inhibitor.
Embodiment 3
Medical grade silicon rubber formula of the present invention is made by the raw material of following mass fraction:
100 parts of methyl vinyl silicone rubbers, 15 parts of polypropylene, 12 parts of sodium starch glycolatees, 8 parts, gelatin, 8 parts of octamethylcyclotetrasilazanes, 5 parts of dioctyl phthalate (DOP)s, 7 parts of lactic acid, 5 parts of containing hydrogen silicone oils, 4 parts of Vulcanization accelerator TMTDs, 2.5 parts of dicumyl peroxides, 5 parts, zinc oxide, 3 parts of stearic acid, 1.5 parts of Microcrystalline Waxes, 2 parts of white carbon blacks, 5 parts, oxidation inhibitor.
Dioctyl phthalate (DOP) in embodiment 1-3 is medical grade; Oxidation inhibitor is comprised of antioxidant 1010 and antioxidant 1076, and ratio is between the two 1:1.
Formula described in embodiment 1-3 carries out the preparation of medical grade silicon rubber according to the following step:
(1) first methyl vinyl silicone rubber, polypropylene are joined to rubber mixing machine bag roller, then add sodium starch glycolate, gelatin, octamethylcyclotetrasilazane, dioctyl phthalate (DOP), lactic acid, Vulcanization accelerator TMTD, dicumyl peroxide, zinc oxide, thin-pass 5 times, lower, heat-treat;
(2), by the back mixing on rubber mixing machine of the sizing material after thermal treatment, clot, lower obtain rubber unvulcanizate;
(3) in rubber unvulcanizate, add containing hydrogen silicone oil, oxidation inhibitor, stearic acid, Microcrystalline Wax, white carbon black, after fully mixing, blank is stand-by;
(4) with Rubber Extruder, material is extruded, through hot-air vulcanization moulding, curing temperature is 150-160 ℃.
The silicon rubber of according to China's GB being prepared by embodiment 1-3 carries out mechanical property and biological property index determining, and result is as shown in table 1,2;
The mechanical performance index of medical grade silicon rubber prepared by table 1 the present invention
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Shore a hardness/degree | 60 | 65 | 71 |
| Tensile strength/MPa | 7.9 | 8.8 | 9.2 |
| Tear strength/kN.m -1 | 33 | 39 | 45 |
| Compression set/% | 2.3 | 3.1 | 3.6 |
| Hot air aging coefficient | 0.73 | 0.88 | 0.85 |
The biological property index of medical grade silicon rubber prepared by table 2 the present invention
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Cell toxicity test | Qualified | Qualified | Qualified |
| Acute toxicity test | Qualified | Qualified | Qualified |
| Intracutaneous irritant test | Qualified | Qualified | Qualified |
| Short-term muscle Implant experiment | Qualified | Qualified | Qualified |
By table 1,2, can be found out, medical grade silicon rubber prepared by the present invention not only has good mechanical property, stability, thermotolerance, resistance to deterioration, also has nontoxic, nonirritant, to the safe feature of organism.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and specification sheets, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (4)
1. a medical grade silicon rubber formula, it is characterized in that, by the raw material of following mass fraction, made: methyl vinyl silicone rubber 80-100 part, polypropylene 10-15 part, sodium starch glycolate 8-12 part, gelatin 5-8 part, octamethylcyclotetrasilazane 4-8 part, dioctyl phthalate (DOP) 2-5 part, lactic acid 3-7 part, containing hydrogen silicone oil 2-5 part, Vulcanization accelerator TMTD 1-4 part, dicumyl peroxide 1-2.5 part, zinc oxide 3-5 part, stearic acid 1-3 part, Microcrystalline Wax 0.5-1.5 part, white carbon black 1-2 part, oxidation inhibitor 2-5 part.
2. a kind of medical grade silicon rubber formula according to claim 1, is characterized in that: described dioctyl phthalate (DOP) is medical grade.
3. a kind of medical grade silicon rubber formula according to claim 1, is characterized in that: described oxidation inhibitor is comprised of antioxidant 1010 and antioxidant 1076, and ratio is between the two 1:1.
4. a preparation method for medical grade silicon rubber, is characterized in that, comprises the following steps:
(1) first methyl vinyl silicone rubber, polypropylene are joined to rubber mixing machine bag roller, then add sodium starch glycolate, gelatin, octamethylcyclotetrasilazane, dioctyl phthalate (DOP), lactic acid, Vulcanization accelerator TMTD, dicumyl peroxide, zinc oxide, thin-pass 5 times, lower, heat-treat;
(2), by the back mixing on rubber mixing machine of the sizing material after thermal treatment, clot, lower obtain rubber unvulcanizate;
(3) in rubber unvulcanizate, add containing hydrogen silicone oil, oxidation inhibitor, stearic acid, Microcrystalline Wax, white carbon black, after fully mixing, blank is stand-by;
(4) with Rubber Extruder, material is extruded, through hot-air vulcanization moulding, curing temperature is 150-160 ℃.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410348527.3A CN104177836A (en) | 2014-07-21 | 2014-07-21 | Medical silicon rubber formula and preparation method thereof |
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| CN201410348527.3A CN104177836A (en) | 2014-07-21 | 2014-07-21 | Medical silicon rubber formula and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104962080A (en) * | 2015-06-30 | 2015-10-07 | 苏州乔纳森新材料科技有限公司 | Medical silicone rubber and preparation method thereof |
| CN105295385A (en) * | 2015-10-21 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Non-toxic environment-friendly medical silicone rubber and preparation method thereof |
| CN105295384A (en) * | 2015-10-21 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Medical silicone rubber and preparation method thereof |
| CN105315676A (en) * | 2015-10-21 | 2016-02-10 | 安徽中马橡塑制品有限公司 | Medical silicone rubber and polyvinyl acetate latex co-polymerized rubber plug and preparation method thereof |
| CN105440697A (en) * | 2015-12-11 | 2016-03-30 | 广东实联医疗器械有限公司 | Annular elastic ring for medical loop ligation device |
| CN105860534A (en) * | 2016-06-17 | 2016-08-17 | 叶伟然 | Novel medical silicon rubber material |
| CN105968815A (en) * | 2016-07-04 | 2016-09-28 | 苏州云舒新材料科技有限公司 | Medical modified silicon rubber material |
| US11352584B2 (en) | 2017-02-22 | 2022-06-07 | Infineum International Limited | Lubricating oil compositions containing pre-ceramic polymers |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408948A (en) * | 2013-08-09 | 2013-11-27 | 浙江合盛硅业有限公司 | Rubber composition and application thereof |
-
2014
- 2014-07-21 CN CN201410348527.3A patent/CN104177836A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408948A (en) * | 2013-08-09 | 2013-11-27 | 浙江合盛硅业有限公司 | Rubber composition and application thereof |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104962080A (en) * | 2015-06-30 | 2015-10-07 | 苏州乔纳森新材料科技有限公司 | Medical silicone rubber and preparation method thereof |
| CN105295385A (en) * | 2015-10-21 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Non-toxic environment-friendly medical silicone rubber and preparation method thereof |
| CN105295384A (en) * | 2015-10-21 | 2016-02-03 | 安徽中马橡塑制品有限公司 | Medical silicone rubber and preparation method thereof |
| CN105315676A (en) * | 2015-10-21 | 2016-02-10 | 安徽中马橡塑制品有限公司 | Medical silicone rubber and polyvinyl acetate latex co-polymerized rubber plug and preparation method thereof |
| CN105440697A (en) * | 2015-12-11 | 2016-03-30 | 广东实联医疗器械有限公司 | Annular elastic ring for medical loop ligation device |
| CN105440697B (en) * | 2015-12-11 | 2018-04-17 | 广东实联医疗器械有限公司 | A kind of medical looping and binding device annular resilient collar |
| CN105860534A (en) * | 2016-06-17 | 2016-08-17 | 叶伟然 | Novel medical silicon rubber material |
| CN105968815A (en) * | 2016-07-04 | 2016-09-28 | 苏州云舒新材料科技有限公司 | Medical modified silicon rubber material |
| US11352584B2 (en) | 2017-02-22 | 2022-06-07 | Infineum International Limited | Lubricating oil compositions containing pre-ceramic polymers |
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