CN104165864A - Unmarked guided-mode resonance Brewster sensor detection device - Google Patents

Unmarked guided-mode resonance Brewster sensor detection device Download PDF

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CN104165864A
CN104165864A CN 201410447434 CN201410447434A CN104165864A CN 104165864 A CN104165864 A CN 104165864A CN 201410447434 CN201410447434 CN 201410447434 CN 201410447434 A CN201410447434 A CN 201410447434A CN 104165864 A CN104165864 A CN 104165864A
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guided
grating
mode resonance
light source
sensor
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CN 201410447434
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Chinese (zh)
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王振华
蔡强
陈强
俞锡鹏
梁伟
陈诚
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浙江清华长三角研究院
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Abstract

The invention discloses an unmarked guided-mode resonance Brewster sensor detection device. The unmarked guided-mode resonance Brewster sensor detection device comprises an incident light source assembly, a guided-mode resonance grating sensor and a detection optical assembly, wherein the incident light source assembly comprises a laser light source and a beam expander group; the guided-mode resonance grating sensor comprises a grating layer, a waveguide layer and a substrate; the detection optical assembly comprises a CCD linear array and a drive circuit thereof; the beam expander group is installed in front of the laser light source, the waveguide layer is installed above the substrate, the grating layer is installed above the waveguide layer, and the CCD linear array is installed right above the grating layer. The unmarked guided-mode resonance Brewster sensor detection device is high in integration degree and suitable for detecting high-flux samples; the design for entering a guided-mode resonance optical device at a Brewster angle is favorable for actually establishing a biochemical detection device and improving the unmarked optical detection sensitivity.

Description

一种无标记导模共振布儒斯特传感器检测装置 A non-guided mode resonant marker Brewster detecting sensor means

技术领域 FIELD

[0001] 本发明涉及一种光学检测装置,具体是一种无标记导模共振布儒斯特传感器检测 [0001] The present invention relates to an optical detection device, in particular a non-guided mode resonant marker sensor for detecting the Brewster

>JU ρςα装直。 > JU ρςα loaded straight.

背景技术 Background technique

[0002] 无标记光学检测是利用光的相干反射(coherentreflect1n)、衍射(DiffractiveOptics)及表面等离子体共振(SurfacePlasmonResonance, SPR)等现象建立起来的对生物化学反应进行直接测定的新型检测技术。 [0002] The label-free optical coherence reflectometry is detected (coherentreflect1n) using light diffraction (DiffractiveOptics) and surface plasmon resonance (SurfacePlasmonResonance, SPR) phenomenon on the biochemical reactions set up for new direct detection assay. 该技术避免了标记和破坏待检测对象,消除了标记物对检测造成干扰的可能性,尤其适合进行生物分子间的相互作用过程和需要极低浓度的应用检测,在环境和食品安全监测等领域具有广泛的应用前景。 This technique avoids the damage marks to be detected and objects, eliminating the possibility of causing interference to the marker detection, particularly suitable for application detection process of interaction between the biomolecule and require very low concentrations, food safety and environmental monitoring, etc. It has a wide range of applications.

[0003] 基于导模共振效应(Guided_modeResonance,GMR)的光学生物传感器,具有卓越的光学灵敏度和稳定性,此类器件通常包括波导层和光栅层,当一束光以一定角度照射后,只有特定波长的光会被反射,反射光的波长、角度的大小与器件所处环境的有效折射率有关。 [0003] Based on optical biosensor guided mode resonance effect (Guided_modeResonance, GMR) having excellent optical sensitivity and stability, such a device generally comprises a waveguide layer and the grating layer, when irradiated with a light beam at a certain angle, only the specific For light is the effective refractive index of the environment and the size of the reflection device, the wavelength of the reflected light, the angle of the wavelength. 在光栅上涂一层试剂,将盛有样本溶液的容器置于光栅上,如果样本中的物质与试剂层发生反应,有效折射就会改变,从而改变反射光的波长、角度。 Reagent layer is coated on the grating, the container containing a sample solution is placed on the grating, if the sample in the reagent layer reacts with the substance, the effective refractive will change, thereby changing the wavelength of the reflected light angle. 基于GMR效应的无标记光学检测器件,检测灵敏度高,适用于高通量检测,并能实现生物分子相互作用的实时反应动力学检测和定量分析。 Based label-free optical detection device GMR effect, high detection sensitivity, suitable for high-throughput detection, and can achieve real-time reaction kinetics detecting biomolecular interactions and quantitative analysis.

[0004] 在现有的研究中,多数采用宽带连续光源,通过附着样品分子间的变化,转变为共振峰的移动,通过检测共振峰波长的变化量,获得样品信息。 [0004] In the prior study, the majority of a continuous broadband light source, by attaching molecules change between samples, into moving formant by detecting the amount of change in resonance peak wavelength to obtain sample information. 而实际使用中,由于待测生物样品对共振波长的移动量非常小,通常在纳米量级,使得传感器的检测灵敏度达不到所需要求。 In actual use, since the amount of movement of the biological sample to be tested resonance wavelength is very small, typically in the order of nanometers, so that the detection sensitivity of the sensor does not reach the necessary requirements.

发明内容 SUMMARY

[0005] 本发明的目的在于提供一种集成度高、适用于高通量样品检测的无标记导模共振布儒斯特传感器检测装置,以解决上述背景技术中提出的问题。 [0005] The object of the present invention is to provide a high integration, high throughput sample suitable for detection of guided-mode resonance label free sensor Brewster detection means to solve the problems raised in the background art.

[0006] 为实现上述目的,本发明提供如下技术方案: [0006] To achieve the above object, the present invention provides the following technical solutions:

一种无标记导模共振布儒斯特传感器检测装置,包括入射光源组件、导模共振光栅传感器和检测光学组件,入射光源组件包括激光器光源和扩束镜组;导模共振光栅传感器包括光栅层、波导层和基底;检测光学组件包括CXD线阵及其驱动电路;所述扩束镜组安装在激光器光源的前方,所述波导层安装在基底的上方,所述光栅层安装在波导层上方,所述CXD线阵安装在光栅层的正上方。 A non-guided mode resonant marker Brewster sensor testing apparatus, comprising an incident light source assembly, and a guided-mode resonance grating sensor detecting optical components, the incident light source assembly includes a laser light source and a beam expander lens assembly; guided-mode resonance grating sensor comprises a grating layer the waveguide layer and the substrate; optical detecting assembly includes a linear array and a drive circuit CXD; a beam expander lens assembly mounted in front of the laser light source, the waveguide layer is mounted above the substrate, the grating layer over the waveguide layer is mounted , the CXD linear array is mounted directly above the grating layer.

[0007] 作为本发明进一步的技术方案:所述光栅层上的光栅为亚波长光栅。 [0007] As a further aspect of the present invention: the grating on the grating layer is a sub-wavelength grating.

[0008] 所述无标记导模共振布儒斯特传感器检测装置的使用方法,包括如下步骤:1)打开入射光源组件、导模共振光栅传感器和检测光学组件的开关;2)激光器光源产生入射光线,经过扩束镜组倾斜入射到导模共振光栅传感器的光栅层上,再经过波导层和基底后产生导模共振;3)将待检测物质与导模共振光栅传感器紧密结合,CCD线阵检测激光信号共振角度变化量,得到测试结果。 [0008] The label-free guided mode resonant Brewster method using a sensor detecting apparatus, comprising the steps of: 1) Open the incident light source assembly, and a guided-mode resonance grating sensor detecting optical switch assembly; 2) generating an incident laser light light, through the beam expander lens assembly obliquely incident on the guided-mode resonance grating sensor grating layer, and then through the waveguide layer and the substrate is generated guided-mode resonance; 3) the substance to be detected and guided-mode resonance grating sensor closely, the CCD linear angle variation detecting laser resonator signal to obtain the test results.

[0009] 与现有技术相比,本发明的有益效果是: [0009] Compared with the prior art, the beneficial effects of the present invention are:

本发明集成度高,非常适用于高通量样品检测,此类以布儒斯特角倾斜入射导模共振光学器件的设计,对于实际搭建生化检测装置、提高无标记光学检测灵敏度是非常有利的。 The present invention is highly integrated, very suitable for high throughput sample testing, such Brewster angle obliquely incident guided mode resonant optical device design, build actual biochemical detection means, to improve the optical label-free detection sensitivity is very advantageous for the .

附图说明 BRIEF DESCRIPTION

[0010] 图1为本发明结构示意图。 [0010] Fig 1 a schematic view of the structure of the present invention.

[0011] 图2为本发明共振角度位置与各待检测样品折射率关系图。 [0011] FIG. 2 of the present invention, the resonance angular position of each test sample refractive index to be the relationship of FIG.

[0012] 图3为本发明中入射媒质折射率nc从I增加到1.77时共振角度位置变化曲线。 [0012] The present invention FIG 3 is incident upon the medium from 1.77 refractive index nc resonance angular position curve I increases.

[0013] 图中:1_激光器光源;2-扩束镜组;3_C⑶线阵;5_光栅层;6_波导层;7_基底。 [0013] FIG: 1_ laser light source; 2- beam expander lens assembly; 3_C⑶ linear array; 5_ grating layer; 6_ waveguide layer; 7_ substrate.

具体实施方式 detailed description

[0014] 下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。 [0014] below in conjunction with the present invention in the accompanying drawings, technical solutions of embodiments of the present invention are clearly and completely described, obviously, the described embodiments are merely part of embodiments of the present invention, but not all embodiments example. 基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。 Based on the embodiments of the present invention, all other embodiments of ordinary skill in the art without any creative effort shall fall within the scope of the present invention.

[0015] 请参阅图1,本发明实施例中,对于双层膜光栅结构,由光栅层和均值膜层组成,光栅位于最外层,均值膜层作为波导层,参数为:nc=l,基底折射率ns=l.52,光栅占空比f=0.5,光栅层材料高折射率nh=2, nl=l.52, dg=175nm, A =266.2nm, nl=l.98, dl=180nm, A射波长为632.8nm。 [0015] Referring to FIG. 1, an embodiment of the present invention, for the double membrane structure of the grating, and the grating layer film composed of the mean grating the outermost layer, the mean film as a waveguide layer, the parameters are: nc = l, the refractive index of the substrate ns = l.52, grating duty ratio f = 0.5, the high refractive index grating layer material nh = 2, nl = l.52, dg = 175nm, A = 266.2nm, nl = l.98, dl = 180nm, A emission wavelength of 632.8nm.

[0016] 实施例1 [0016] Example 1

I)打开入射光源组件、导模共振光栅传感器和检测光学组件的开关;2)激光器光源I产生入射光线,经过扩束镜组2倾斜入射到导模共振光栅传感器的光栅层5上,再经过波导层6和基底7后产生导模共振;3)将折射率为I的空气与导模共振光栅传感器紧密结合,CCD线阵3检测激光信号共振角度位置为44.68°。 I) Open the incident light source assembly, guided-mode resonance grating sensor and the detection switch optical components; 2) laser light source I to produce the incident light, through the beam expander lens assembly 2 obliquely incident on the guided-mode resonance grating sensor grating layer 5, and then through waveguide layer 6 and the substrate 7 to generate the guided mode resonance; 3) with a refractive index of air I guided-mode resonance grating sensor closely, CCD linear array 3 detects the angular position of the resonant laser signal 44.68 °.

[0017] 实施例2 [0017] Example 2

O打开入射光源组件、导模共振光栅传感器和检测光学组件的开关;2)激光器光源I产生入射光线,经过扩束镜组2倾斜入射到导模共振光栅传感器的光栅层5上,再经过波导层6和基底7后产生导模共振;3)将折射率为1.333的水与导模共振光栅传感器紧密结合,CCD线阵3检测激光信号共振角度位置为30.22°。 O Open incident light source assembly, guided-mode resonance grating sensor and the detected optical components switch; 2) laser light source I to produce the incident light, through the beam expander lens assembly 2 obliquely incident on the guided-mode resonance grating sensor grating layer 5, and then through the waveguide after generating layer 6 and the substrate 7 guided-mode resonance; 3) to a refractive index of 1.333 and water guided-mode resonance grating sensor closely, CCD linear array 3 detects the angular position of the resonant laser signal 30.22 °.

[0018] 实施例3 [0018] Example 3

O打开入射光源组件、导模共振光栅传感器和检测光学组件的开关;2)激光器光源I产生入射光线,经过扩束镜组2倾斜入射到导模共振光栅传感器的光栅层5上,再经过波导层6和基底7后产生导模共振;3)将折射率为L 377的异丙醇与导模共振光栅传感器紧密结合,CXD线阵3检测激光信号共振角度位置为28.63°。 O Open incident light source assembly, guided-mode resonance grating sensor and the detected optical components switch; 2) laser light source I to produce the incident light, through the beam expander lens assembly 2 obliquely incident on the guided-mode resonance grating sensor grating layer 5, and then through the waveguide after generating layer 6 and the substrate 7 guided-mode resonance; 3) L 377 isopropanol refractive index guided-mode resonance grating sensors with closely, CXD linear array 3 detects the angular position of the resonant laser signal 28.63 °.

[0019] 实施例4 [0019] Example 4

O打开入射光源组件、导模共振光栅传感器和检测光学组件的开关;2)激光器光源I产生入射光线,经过扩束镜组2倾斜入射到导模共振光栅传感器的光栅层5上,再经过波导层6和基底7后产生导模共振;3)将折射率为L 479的二甲基亚砜与导模共振光栅传感器紧密结合,CXD线阵3检测激光信号共振角度位置为24.96°。 O Open incident light source assembly, guided-mode resonance grating sensor and the detected optical components switch; 2) laser light source I to produce the incident light, through the beam expander lens assembly 2 obliquely incident on the guided-mode resonance grating sensor grating layer 5, and then through the waveguide after generating layer 6 and the substrate 7 guided-mode resonance; 3) to a refractive index of dimethylsulfoxide L 479 and the guide mode resonance grating sensor closely, CXD linear array 3 detects the angular position of the resonant laser signal 24.96 °.

[0020] 请参阅图2〜3,由以上实施例所得数据可知:随着入射媒质折射率的增加,共振角度位置明显变化且逐渐减小,由44.68°减小为24.96°,当入射媒质折射率nc从I增加到1.77时,共振角度位置变化曲线,随着入射媒质折射率增加,共振角度也是逐渐减小,在实施例中入射媒质计算范围内,折射率每改变0.1,共振角度位置平均变化3.6°。 [0020] Referring to FIG. 2 or 3, data obtained from the above Example demonstrates embodiment: With the increase of the refractive index of an incident medium, and a significant change in the angular position of the resonance decreases, reduced from 44.68 ° to 24.96 °, when incident media refractive from 1.77 I nc rate increases, the angular position of the resonance curve, the refractive index increases as the incident medium, the resonance angle is gradually reduced, in the embodiment, the calculation range of the incident medium, the refractive index change per 0.1, average resonant angular position change 3.6 °.

[0021] 本发明集成度高,非常适用于高通量样品检测,此类以布儒斯特角倾斜入射导模共振光学器件的设计,对于实际搭建生化检测装置、提高无标记光学检测灵敏度是非常有利的。 [0021] The present invention is highly integrated, very suitable for high throughput sample testing, such Brewster angle obliquely incident guided mode resonant optics design, build actual biochemical detection means, to improve the detection sensitivity of the optical label-free very favorable.

[0022] 对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。 In the case [0022] to those skilled in the art, that the invention is not limited to the details of the above-described exemplary embodiment, but without departing from the spirit or essential characteristics of the present invention, the present invention can be realized in other specific forms. 因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。 Therefore, no matter from what point of view, the embodiments should be considered exemplary, and not limiting, the scope of the invention being indicated by the appended claims rather than by the foregoing description, the appended claims are therefore intended to All changes which come within the meaning and range of equivalents thereof are within the present invention include. 不应将权利要求中的任何附图标记视为限制所涉及的权利要求。 In the claims should not be considered as any reference numerals as claimed in claim limitations involved.

[0023] 此外,应当理解,虽然本说明书按照实施方式加以描述,但并非每个实施方式仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。 [0023] Further, it should be understood that while the present specification be described in terms of embodiments, but not every embodiment contains only a separate aspect, this narrative description only for the sake of clarity, those skilled in the specification should as a whole, the technical solutions in the respective embodiments may be suitably combined to form other embodiments of the present art can be appreciated in the art.

Claims (3)

  1. 1.一种无标记导模共振布儒斯特传感器检测装置,其特征在于,包括入射光源组件、导模共振光栅传感器和检测光学组件,入射光源组件包括激光器光源(I)和扩束镜组;导模共振光栅传感器包括光栅层、波导层(6)和基底(7);检测光学组件包括CXD线阵(3)及其驱动电路;所述扩束镜组(2 )安装在激光器光源(I)的前方,所述波导层(6 )安装在基底(7 )的上方,所述光栅层(5)安装在波导层(6)上方,所述CCD线阵(3)安装在光栅层(5)的正上方。 1. A non-guided mode resonant marker Brewster sensor testing apparatus, characterized by comprising an incident light source assembly, and a guided-mode resonance grating sensor detecting optical components, the incident light source assembly includes a laser light source (I) and a beam expander lens assembly ; guided-mode resonance grating sensor comprising a grating layer, a waveguide layer (6) and the substrate (7); CXD detecting optical assembly includes a linear array (3) and a drive circuit; the extender lens group (2) is mounted in the laser light source ( forward I) of the waveguide layer (6) is mounted above the substrate (7), said grating layer (5) is mounted above the waveguide layer (6), said CCD line (3) mounted on the grating layer ( 5) just above.
  2. 2.根据权利要求1所述的一种无标记导模共振布儒斯特传感器检测装置,其特征在于,所述光栅层(5)上的光栅为亚波长光栅。 According to one of the claims 1 without marking guided mode resonant sensor detecting apparatus Brewster, wherein said grating (5) is a grating layer sub-wavelength grating.
  3. 3.一种采用如权利要求1-2之一所述的无标记导模共振布儒斯特传感器检测装置的使用方法,其特征在于,包括如下步骤:1)打开入射光源组件、导模共振光栅传感器和检测光学组件的开关;2)激光器光源(I)产生入射光线,经过扩束镜组(2)倾斜入射到导模共振光栅传感器的光栅层(5 )上,再经过波导层(6 )和基底(7 )后产生导模共振;3 )将待检测物质与导模共振光栅传感器紧密结合,CCD线阵(3)检测激光信号共振角度变化量,得到测试结果。 A non-use of the labeled one of claims 1-2 guided mode resonant Brewster method using a sensor detecting apparatus, characterized by comprising the following steps: 1) Open the incident light source assembly, the guide mode resonance grating sensor and a detection optical components switch; 2) laser light source (I) to generate incident light, through the beam expander lens group (2) obliquely incident on the guided-mode resonance grating sensor grating layer (5), then through the waveguide layer (6 post) and the substrate (7) to produce resonant guided mode; 3) the substance to be detected and guided-mode resonance grating sensor closely, the CCD linear array (3) the angle variation detection signal laser resonator, test results obtained.
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CN104634453A (en) * 2015-02-03 2015-05-20 上海理工大学 Method for detecting linear polarization incident light polarization angle
CN105651730A (en) * 2016-03-14 2016-06-08 上海理工大学 Organic gas detection device based on guided-mode resonance principle

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