CN104146181A - Heat-stress resistance regulator for dogs - Google Patents
Heat-stress resistance regulator for dogs Download PDFInfo
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- CN104146181A CN104146181A CN201410410830.1A CN201410410830A CN104146181A CN 104146181 A CN104146181 A CN 104146181A CN 201410410830 A CN201410410830 A CN 201410410830A CN 104146181 A CN104146181 A CN 104146181A
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Abstract
The invention belongs to the technical field of production of animal feed additives, and concretely relates to a heat-stress resistance regulator for dogs. The heat-stress resistance regulator for dogs comprises the following ingredients: glutamine 18%, taurine 18%, beta glucan 18%, VC 23%, VE 9%, organic chromium 1%, organic selenium 1%, and organic zinc 11%. The heat-stress resistance regulator for dogs contains various nutrients and bioactive substances, and can fully regulate the body's physiological function. The regulator has features of such as reliable resources of the ingredients, quality assurance, processing convenience, stable composition, no residue, non-toxic and no drug resistance. The test results show that the regulator can make the dog's physiological and biochemical indicators tend to be stable in the thermal environment, maintain normal immune function, regulate endocrine, and reduce the damage on cell due to heat stress.
Description
One, technical field
The invention belongs to animal feed additive production technical field, be specifically related to a kind of dog anti-heat stress conditioning agent.
Two, background technology
Stress be body to external world or the nonspecific reaction that produces of inner various stimulations, can cause the even generation of disease of tissue damage.Various abnormal environments all can have a strong impact on animal health condition and production performance as high temperature, noise, overtired, long-distance transport, psychological stress etc.
In recent years, police dog in criminal investigation, keep a lookout of public security, drug law enforcement, safety check, search the aspect such as quick-fried, anti-riot and more and more given play to important effect, the unique effect of technique of patrol dog in public security work is also day by day obvious.Police dog is dispensed into many categories within police force as police equipment, in police service actual combat, has obtained extensive utilization.Add that large-scale security activity increases increasingly, it is especially outstanding that the importance of police dog seems.And can often contact hot environment in the use procedure of police dog, heat stress has a strong impact on sense of smell, behavior performance and the health status of police dog.Especially the Yangtze river basin and areas to the south's summer fever thereof are stress phenomenon fairly obvious, have had a strong impact on the normal performance of police dog ability to work.
Three, summary of the invention
The problem that the present invention need to solve is to provide a kind of feed addictive of resisting dog heat stress, makes dog in hot environment, reduce stress reaction, maintains the normal physiological function of dog.
Technical scheme of the present invention:
Dog anti-heat stress conditioning agent of the present invention is comprised of following component:
Glutamine 18%, taurine 18%, beta glucan 18%, VC23%, VE9%, Organic Chromium 1%, Organic Selenium 1%, organic zinc 11%.Evenly mix in mass ratio, compacting in flakes, is dog anti-heat stress conditioning agent after packing.
(1) glutamine
Glutamine (Gln) is the abundantest a kind of nonessential amino acid of content in body, is bringing into play in vivo important physiological function.Skeletal muscle is the major organs that body synthesizes and discharge Gln, and Gln is the carrier that muscle discharges non-toxic ammonia, and the metabolism of Gln is also the main detoxification pathways of brain.The concentration of the interior Gln of normal bone myocyte is 30 times of PC.Gln has important and unique physiological function to each Organ and tissue cell, the research of mankind's clinical medicine show Gln have regulate acid-base balance, anti-stress, anti-infective, antifatigue, anti-oxidant, antitumor, strengthen the functions such as immunocompetence.
Glutamine has important and unique physiological function to each Organ and tissue cell: after the de-phthalein amino of (1) glutamine hydrolysis, generate glutamic acid, remaining alpha-amido plays an important role in the generation of other various a-amino acids by turning amino approach; (2) glutamine is the synthetic important as precursors of biomolecule such as purine, pyrimidine, amino acid, protein, nucleic acid; (3) glutamine plays a very important role the adjusting of acid-base balance; (4) glutamine is the important substrate of hepatic glycogen heteroplasia; (5) glutamine is main carriers and the dead end product that liver catches ammonia, has the function of removing toxic substances; (6) glutamine is Fast Growth and noble cells, as the important fuel of vascular endothelial cell, lymphocyte, intestinal epithelial cell, tumour cell; (7) glutamine is some glutamine dependent cells, as the important energy supply material of intestinal epithelial cell, is also that some relies on the synthetic impaired rear most important alternative route of ATP approach of glucose; (8) glutamine is the important regulatory factor of protein metabolism, as promoted the synthetic of the large biological molecules such as intracellular protein, reduces the decomposition of protein in skeletal muscle.
In recent decades, oneself has had a lot of research the metabolic function of glutamine, and same glutamine is the study hotspot of glutamine in clinical application always.Supplement Gln to maintaining immunologic function, promote protein synthetic, acceleration body recovery etc. has important effect.
(2) taurine
Taurine (Taurine) claim again Tau, separates the earliest in cow-bezoar, is a kind of non-protein amino acid of sulfur-bearing, do not participate in the biosynthesis of albumen in body.In animal body, taurine extensively distributes, although taurine does not participate in protein, does not synthesize, and to maintaining organism physiology function, plays an important role.
1, immunoregulation effect
In neutrophil leucocyte and lymphocyte, a large amount of taurine of content, can promote lymphopoiesis.The effect of taurine on cell proliferation is by Cell protection film, regulates osmotic pressure, prevents that cell from bursting sex change, and then reduces the quantity of cell death.Research shows, taurine can significantly reduce the endothelial cell toxin of the recombination leukocyte mesonium-2 activation being mediated by NK, and does not reduce recombination leukocyte mesonium-2 GVT; Meanwhile, suppress the endothelial cell dissolving of lymphokin activated killer cells mediation.Taurine can also promote the forward of interleukin 1 to regulate, thereby increases the generation of interferon.
2, antioxidation
Ox Foundation acid can keep the dynamic equilibrium of oxidative and anti-oxidative in body, stops too much free radical to attack the biomembrane of body, improves body superoxide dismutase and glutathione peroxidase activity, strengthens the oxidation resistance of body.
(3) beta glucan
Beta glucan is extensively present in many bacteriums, fungi, mushroom swallow, marine alga and higher plant, can improve the immunocompetence of cell, can strengthen the immunologic function of body.
Beta glucan can continue to produce to stimulate activating macrophage, neutrophil leucocyte and monocyte etc. to prevent and engulfs the invasion of harmful substance and guide immunocyte to move to foreign matter place, improves the phagocytic activity of macrophage.And can promote cytokine secretion.
(4) vitamin C
Vitamin C participates in multiple metabolic process in animal body, having the synthesis that maintains normal blood lipid metabolism, cardiac function, central functions, hematopoiesis function and promote multiple hormone in body, is requisite nutriment in animal survival, growth, development and fecundity process.Vitamin C can guarantee the stably excreting of glucocorticoid, for heat radiation provides enough energy, also can participate in cell immune response directly; increase human body immune function; improve anti-stress ability, the reduction of the polyphenoils activity that alleviation stress cause, protection biomembrane is avoided infringement.The reports such as Sun Qiying add respiratory rate and body temperature that VC7 can reduce milk cow in heat stress phase dairy cow diet.
1, promote the formation of collagen and the metabolism of steroids
The formation of collagen comprises gently to be changed proline and forms a stable extracellular matrix, by lysine through change and glycosylation and fibroreticulate formation etc.And ascorbic effect is to activate, proline is gently changed enzyme and lysine is gently changed enzyme; promote proline and lysine to the conversion through proline and light lysine; the enzyme that protection participation gently turns use into is not oxidized by iron ion and sulfenyl, and then promotes the formation of collagen in histocyte interstitial.On the other hand, vitamin C can participate in the light glycosylation reaction of steroids, as short, says that cholesterol is converted into bile acid, cortin and sex hormone etc.
2, participate in redox reaction and other metabolic responses in body
Oxidized-reduction that vitamin C is easy to plays an important role in the electron transfer process of cell.At folic acid, change in tetrahydrofolic acid process, tyrosine metabolic process and cortex hormone of aadrenaline building-up process and all need ascorbic participation.In addition, vitamin C also participates in the synthetic of the interior carnitine of body and dopamine, and promotes the absorption of enteron aisle iron and the activation of vitamin D.When therefore, body Nei Weiniu element C lacks, will cause metabolic disorder.
3, antioxidant function
Vitamin C can reduce lipid peroxidation and serum cholesterol, participates in liver detoxification, with nitrate reaction, thereby suppresses the pre-anti-cancer of generation of sub-acid amide.
4, immunologic function in reinforcement
Vitamin C can stimulate leukocytic activate the phagocytic capacity, improves the function of reticuloendothelial system, the formation of enhancing antibody.
5, the favourable dry integrality that maintains cell membrane
The easy oxidized generation fat peroxide of unrighted acid in body (UFA), can make various membranolysises.Reductive glutathione can make fat peroxide be reduced into hydroxy compounds, and self is transformed into oxidized form of glutathione, thereby eliminates the destruction of fat peroxide cell membrane.Vitamin C has stronger reproducibility (non-oxidizability), under the effect of glutathione reductase, can make oxidized form of glutathione be reduced to reductive glutathione, thereby maintain the integrality of cell membrane.
(5) organic zinc
Zinc has physiological action widely in animal body.In recent years, manyly studies confirm that organic zinc can promote growth of animal, breeding and health status.In daily ration, add certain organic zinc, can improve immunity of organisms and reproductive performance, effectively reduce disease incident, improve animal health.
The invention has the beneficial effects as follows
What the present invention developed stress conditioning agent main component be glutamine, taurine, electrolytes and minerals etc.; these compositions can maintain organism physiology function; there are immunological regulation or the effect such as anti-oxidant, can resist the body injury that stress cause to a certain extent.Make dog in hot environment, reduce stress reaction, maintain the normal physiological function of dog.Anti-dog heat stress conditioning agent contains multiple nutritional components and bioactivator, comprehensively conditioning engine body physiological function.Its raw material sources are reliable, have quality assurance, easy to process, stable components, noresidue, nontoxicity, without features such as the resistances to the action of a drug.According to test, this conditioning agent can make dog physiological and biochemical index in thermal environment tend towards stability, and maintains normal immunologic function, regulates endocrine, reduces the damage of heat stress to cell.
Four, the specific embodiment
1, the preparation of dog anti-heat stress conditioning agent:
By above-mentioned each component ratio, mix film-making, packing.Press 440mg/ day continuous oral
2. the application example of dog anti-heat stress conditioning agent:
Body condition is good, body weight is close, the adult Labrador Retriever at 12-18 monthly age to choose 24, be divided at random 3 groups, every group 8, be respectively control group (not feeding conditioning agent), test I group (adding 1 conditioning agent every day), test II group (adding 5 conditioning agents every day), conditioning agent is 0.5g/ grain.The test dog full price of feeding coordinate to be grown up twice of dog feed every day.After tested dog whole stress during in moderate heat stress environment.Test dog 10:00 in the 0th day, 7 days, 14 days, 21 days, the 28 day morning surveys rectal temperature, respiratory rate; Gather non-anticoagulation separation of serum, for the detection of blood parameters, immune indexes, endocrine indexes Antioxidant Indexes and heat stress proteins.
(1). conditioning agent is on continuing the impact of heat stress dog rectal temperature, respiratory rate
Rectal temperature determination test I group the 21st day and the 28th day, significantly than control group low 2% and 2.7%, are respectively 39.99 ℃ and 40.18 ℃; Test II group rectal temperature the 28th day is lower by 0.9% than control group, is 40.94 ℃.Take after conditioning agent, test I group respiratory rate the 7th, 14,21,28 days respectively than contrast organize low by 4.41%, 6.26%, 32.92%, 21.60%, be 48.75 times/min, 47.81 times/min, 51.75 times/min, 58.12 times/min.Visible, add rectal temperature and respiratory rate that conditioning agent can significantly reduce Dog Under Hot And Humid Environment, can improve the behavior of police dog.Test I group effect is the most obvious.
(2). conditioning agent is on continuing the impact of heat stress dog blood parameters
Glutamic-pyruvic transaminase (ALT) the 7th day test I group, II organize extremely significantly than control group low 30.88% and 29.01%, are respectively 49.17U/L and 50.50U/L; Control group is down to 49.50U/L on the 28th day; And test I, II group all remains on 57.00U/L and below 63.14U/L, the 28th day is 43.71U/L and 56.00U/L.
Creatine kinase (CK) all raises on the 7th day, and test I, II group, obviously than control group low 21.40% and 25.49%, is respectively 372.17U/L and 352.80U/L.
7 days test I, II groups of glucose (GLU) density control, significantly than control group low 40.95% and 48.22%, are respectively 3.49mmol/L and 3.06mmol/L; The 28th day, test I group was significantly low by 14.83% than control group, is 6.32mmol/L.
Visible test group obviously suppresses the rising of ALT, CK, GLU under hot and humid environment, and test I group tends towards stability, and variation tendency is better than testing II group.
(3). conditioning agent is on continuing the impact of heat stress dog immune indexes
Interleukin 2 (IL-2) concentration, test I group is respectively 407.01ng/L, 497.64ng/L than control group high 30.66% and 53.16% in the 7th, 14 days; Test II group, than control group high 37.59% and 26.98%, is respectively 428.61ng/L, 412.59ng/L.Illustrate that adding conditioning agent can improve the immunity function that continues heat stress dog to a certain extent, is conducive to improve the tolerance of dog in hot environment.
(4). conditioning agent is on continuing the impact of heat stress dog endocrine indexes
Cortisol (COR) density control 7,14,21,28 days, test I group respectively lower by 27.36% than control group, 32.61%, 44.74%, 48.63%, be 28.83pg/ml, 27.51pg/ml, 23.62pg/ml, 21.54pg/ml; Test II group respectively lower by 2.77% than control group, 1.81%, 21.83%, 24.47%, be 38.59pg/ml, 40.08pg/ml, 33.41pg/ml, 31.67pg/ml.Explanation is taken after conditioning agent when heat stress, and the secretion that can suppress COR increases, and maintains COR concentration, maintains the stable of basal metabolic rate; Test I group effect is better than testing II group.
(5). conditioning agent is on continuing the impact of heat stress dog heat stress proteins
Test I group HSP70 the 7th, 14,21 days respectively than contrast organize high by 4.06%, 11.14%, 2.83%, be 252.36ng/L, 272.05ng/L, 249.01ng/L; Test II group HSP70 the 7th, 14,21,28 days respectively than contrast organize high by 33.43%, 29.73%, 8.71%, 1.04%, be 323.60ng/L, 317.54ng/L, 263.23ng/L, 249.83ng/L.Explanation, at lasting heat stress state, is added conditioning agent and can be promoted HSP70 synthetic, thereby alleviate body tissue damage, improves the ability of opposing heat stress.
In sum, the apparent indexs such as comprehensive dog body temperature, breathing, and endocrine, immunity, biochemical indicator etc., finds that 2 test group all have the effect of alleviating lasting heat stress.And test I group adds 1 conditioning agent group, be generally speaking more better than other groups.The conditioning agent of proof doses can be alleviated dog heat stress preferably.
Anti-dog heat stress conditioning agent be regulate body acid-base balance, maintain cell membrane integrality, promote the formation of collagen and the metabolism of steroids, participate in redox reaction in body and other metabolic responses and reach anti-infective, antifatigue, anti-oxidant, anti-ly stress, strengthen the effects such as immunocompetence.
Claims (1)
1. a dog anti-heat stress conditioning agent; it is characterized in that being formed by following component: glutamine 18%, taurine 18%, beta glucan 18%; VC23%; VE9%, Organic Chromium 1%, Organic Selenium 1%; organic zinc 11%; evenly mix in mass ratio, compacting in flakes, is dog anti-heat stress conditioning agent after packing.
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| CN201410410830.1A CN104146181A (en) | 2014-08-19 | 2014-08-19 | Heat-stress resistance regulator for dogs |
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| CN201410410830.1A CN104146181A (en) | 2014-08-19 | 2014-08-19 | Heat-stress resistance regulator for dogs |
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Citations (5)
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| CN1184407A (en) * | 1995-04-20 | 1998-06-10 | 卡尔特有限公司 | Stress regulator for animals |
| US20080213395A1 (en) * | 2004-10-14 | 2008-09-04 | Adventures Plus Pty Ltd | Method for the Treatment of Gastrointestinal and Other Disorders with an Admixture of Vitamins |
| CN102450397A (en) * | 2010-11-01 | 2012-05-16 | 天津瑞普生物技术股份有限公司 | Diarrhea controlling and deodorizing composition for dogs |
| CN102696908A (en) * | 2012-05-18 | 2012-10-03 | 中国农业科学院兰州畜牧与兽药研究所 | Chinese medicinal food with function of enhancing immunity |
| CN103349184A (en) * | 2006-04-04 | 2013-10-16 | 希尔氏宠物营养品公司 | Compositions and methods for enhancing the antioxidant status of animals |
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2014
- 2014-08-19 CN CN201410410830.1A patent/CN104146181A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184407A (en) * | 1995-04-20 | 1998-06-10 | 卡尔特有限公司 | Stress regulator for animals |
| US20080213395A1 (en) * | 2004-10-14 | 2008-09-04 | Adventures Plus Pty Ltd | Method for the Treatment of Gastrointestinal and Other Disorders with an Admixture of Vitamins |
| CN103349184A (en) * | 2006-04-04 | 2013-10-16 | 希尔氏宠物营养品公司 | Compositions and methods for enhancing the antioxidant status of animals |
| CN102450397A (en) * | 2010-11-01 | 2012-05-16 | 天津瑞普生物技术股份有限公司 | Diarrhea controlling and deodorizing composition for dogs |
| CN102696908A (en) * | 2012-05-18 | 2012-10-03 | 中国农业科学院兰州畜牧与兽药研究所 | Chinese medicinal food with function of enhancing immunity |
Non-Patent Citations (3)
| Title |
|---|
| 周伟伟等: "牛磺酸对可卡犬淋巴细胞转化率的影响研究", 《中国畜牧兽医》 * |
| 王道坤: "预防热应激的八类添加剂", 《中国畜牧业》 * |
| 薛世祥等: "谷氨酰胺联合维生素C对热应激致大鼠肠源性内毒素血症的预防作用", 《第三军医大学学报》 * |
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Application publication date: 20141119 |
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