CN104119577A - Irradiation degradation-resistant and pH-adjustable chitosan gel and preparation method thereof - Google Patents

Irradiation degradation-resistant and pH-adjustable chitosan gel and preparation method thereof Download PDF

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Publication number
CN104119577A
CN104119577A CN 201310153544 CN201310153544A CN104119577A CN 104119577 A CN104119577 A CN 104119577A CN 201310153544 CN201310153544 CN 201310153544 CN 201310153544 A CN201310153544 A CN 201310153544A CN 104119577 A CN104119577 A CN 104119577A
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chitosan
gel
ph
polyethylene glycol
resistant
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CN 201310153544
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Chinese (zh)
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周辉
方月娥
史天义
史歌
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江苏兴通生物科技有限公司
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Abstract

The invention relates to an irradiation degradation-resistant and pH-adjustable chitosan gel and a preparation method thereof. A gel solution is prepared from chitosan, lactic acid, polyethylene glycol or glycerinum and distilled water. The preparation method of the radiation degradation-resistant and pH-adjustable chitosan gel comprises the following steps: taking 1-8 percents by mass of chitosan, dissolving the chitosan in 2-5 percents by mass of lactic acid solution, adding 20-60 percents by mass of polyethylene glycol or glycerinum for reacting, defoaming after the reaction is ended, sterilizing the chitosan by using cobalt 60 gamma ray and subsequently taking out the chitosan. The gel is relatively high in viscosity. The preparation method of the irradiation degradation-resistant and pH-adjustable chitosan gel has the advantages that the irradiated and fertilized chitosan is relatively high in rotary viscosity; polyethylene glycol or glycerinum is added and used for adjusting the pH value of the chitosan gel. The preparation method is simple and mild in process, safe and environment-friendly, good in effect and widely applicable to production.

Description

技术领域 FIELD

[0001] 本发明涉及一种壳聚糖凝胶及其制备方法,具体说是一种耐辐射降解且可调pH 的壳聚糖凝胶及其制备方法。 [0001] The present invention relates to a method for preparing chitosan gel and, in particular to a radiation resistant and tunable degradation of chitosan gel preparation method and pH. 一种耐辐射降解且可调pH的壳聚糖凝胶及其制备方法 Chitosan gels and preparation method thereof and an adjustable resistance to radiation degradation of pH

背景技术 Background technique

[0002] 壳聚糖是甲壳素经过脱乙酰基后的产物,我们通常把脱乙酰度大于60 %或者能溶于稀酸的脱乙酰基产物统称为壳聚糖。 [0002] Chitosan is the product of chitin after deacetylation, we usually greater than 60% deacetylation degree can be dissolved in acid or deacetylation product was referred to as chitosan. 壳聚糖迄今为止发现的唯一天然碱性多糖,而它的本体甲壳素广泛存在于自然界的昆虫类、甲壳类(如虾,蟹)和软体类动物和某些藻类的骨骼以及某些菌类的细胞壁中,是地球上蕴藏量最丰富的有机物之一,其含量仅次于纤维素。 Trona unique polysaccharides chitosan ever found, and its body Chitin widely found in nature insects and crustaceans (such as shrimp, crab) bone and molluscs and certain algae and some fungi the cell wall is one of Earth's most abundant reserves of organic matter, which is second only to cellulose content. 壳聚糖溶于稀酸中,具有很好的生物相容性、抑菌性、保湿性等性质,广泛用于医药、化工、 食品、纺织、环境保护等领域。 Chitosan was dissolved in dilute acid, with good biocompatibility properties, antibacterial properties, moisture resistance, etc., widely used in pharmaceutical, chemical, food, textile, environmental protection.

[0003] 然而,壳聚糖在经过钴-60灭菌后,其粘度会大幅度降低,有的甚至接近于水的粘度,这是因为经过钴-60照过后,壳聚糖分子中的糖苷键被打断,造成其粘度大幅度下降, 但是其化学性质并未改变,不影响其效果,但是在一些行业产品中受到了大大的限制。 [0003] However, chitosan sterilized after cobalt-60, which is a significant reduction in viscosity, or even close to the viscosity of water, this is because after cobalt-60 as after, chitosan molecules glycosidic key is interrupted, resulting in a significant decline in its viscosity, but did not change its chemical properties, does not affect the results, but has been greatly restricted in some products in the industry.

发明内容 SUMMARY

[0004] 本发明的目的是克服上述背景的不足,而提供的一种经过钴-60灭菌后仍具有较高粘度的壳聚糖凝胶的制备方法,而且此凝胶的pH值也提高了,刺激性也降低了。 [0004] The object of the present invention is to overcome the above deficiencies of the background, and a method of providing a Cobalt-60 sterilized after preparation of the chitosan gel having a still higher viscosity, and this also increases the pH of the gel , the irritation is reduced.

[0005] 为实现上述目的,本发明采用的技术方案是:一种耐辐射降解的壳聚糖凝胶,其质量百分比组成为:1 % -8%的壳聚糖,2% -5 %的乳酸溶液,20% -60 %的聚乙二醇或甘油, 其余为蒸馏水。 [0005] To achieve the above object, the present invention adopts the technical solution is: A radiation resistant degradation of chitosan gel, the percentage of the mass of the composition: 1% -8% of chitosan, 2% to 5% lactic acid solution, 20% -60% of polyethylene glycol or glycerol, the balance being distilled water.

[0006] 优选的,所用壳聚糖为酸溶壳聚糖。 [0006] Preferably, the acid-soluble chitosan with chitosan.

[0007] 优选的,所用聚乙二醇可以为聚乙二醇200、聚乙二醇400等。 [0007] Preferably, the polyethylene glycol may be polyethylene glycol 200, polyethylene glycol 400 and the like.

[0008] -种耐辐射降解且可调pH的壳聚糖凝胶的制备方法,其步骤如下:(1)将1% -8 %的壳聚糖溶于2 % -5 %的乳酸中,形成凝胶体系;(2)向凝胶体系中加入20% -60 %的聚乙二醇或甘油。 [0008] - radiation resistant species and tunable degradation of chitosan gel preparation pH, the following steps: (1) 1% chitosan was dissolved in 8% 2% -5% lactic acid, gel system is formed; (2) 20% -60% of polyethylene glycol or glycerol to the gel system.

[0009] 优选的,步骤(2)中加入20% -60%的聚乙二醇或甘油后,再经过辐照灭菌。 [0009] Preferably, after step (2) was added 20% -60% of polyethylene glycol or glycerin, and then after irradiation sterilization.

[0010] 本发明中采用聚乙二醇或甘油,可以在一定程度上促进壳聚糖溶解在酸中,使得生产工艺更为简单,可操作性强。 [0010] employed in the present invention, polyethylene glycol or glycerol, may facilitate the chitosan was dissolved in an acid to a certain extent, so that the production process more simple, easy to operate.

具体实施方式 Detailed ways

[0011] 下面将对本发明实施例中的技术方案进行清晰、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。 [0011] Hereinafter, the present invention, the technical solutions in embodiments be clearly and completely described, obviously, the described embodiments are merely part of embodiments of the present invention rather than all embodiments. 给予本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。 Administering to an embodiment of the present invention, those of ordinary skill in the art to make all other embodiments without creative effort shall fall within the scope of the present invention.

[0012]实例1 : [0012] Example 1:

Claims (6)

  1. 1. 一种耐辐射降解且可调pH的壳聚糖凝胶,其质量百分比组成为:1%-8%的壳聚糖, 2% -5 %的乳酸溶液,20 % -60 %的聚乙二醇或甘油,其余为蒸馏水。 An adjustable resistance to radiation degradation of chitosan and pH of the gel, which in combination by weight: 1% -8% of chitosan, 2-5% lactic acid solution, 20% -60% of a poly ethylene glycol or glycerol, the balance being distilled water.
  2. 2. 根据权利要求1所述的一种耐辐射降解且可调pH的壳聚糖凝胶,其特征在于:所述的壳聚糖为酸溶壳聚糖。 A resistance according to claim 1 and tunable radiation degradation of chitosan gel pH, wherein: the acid-soluble chitosan is chitosan.
  3. 3. 根据权利要求1所述的一种耐辐射降解且可调pH的壳聚糖凝胶,其特征在于:所述聚乙二醇为聚乙二醇200、聚乙二醇400或聚乙二醇600等系列。 3. According to one of the resistance to radiation degradation of claim 1 and the pH adjusted chitosan gels, characterized in that: said polyethylene glycol is polyethylene glycol 200, polyethylene glycol 400 or polyethylene glycol 600 series.
  4. 4. 一种耐辐射降解且可调pH的壳聚糖凝胶的制备方法,其步骤如下:(1)将1% -8% 的壳聚糖溶于2% -5%的乳酸中,形成凝胶体系;(2)向凝胶体系中加入20% -60%的聚乙二醇或甘油。 An adjustable resistance to radiation degradation, and the pH of preparation of the chitosan gel, the following steps: (1) 1% chitosan was dissolved in 8% 2% -5% lactic acid is formed gel system; (2) 20% -60% of polyethylene glycol or glycerol to the gel system.
  5. 5. 根据权利要求4所述的一种耐辐射降解且可调pH的壳聚糖凝胶的制备方法,其特征在于:步骤(2)中加入20% -60%的聚乙二醇或甘油后,再经过辐照灭菌。 5. According to one resistant to claim 4 and tunable radiation degradation of chitosan gel preparation pH, characterized in that: the step (2) was added 20% -60% of polyethylene glycol or glycerol after, and then after irradiation sterilization.
  6. 6. 根据权利要求5所述的一种耐辐射降解且可调pH的壳聚糖凝胶的制备方法,其特征在于:所述的辐照灭菌为钴-60灭菌。 6. According to one resistant to claim 5 and tunable radiation degradation of chitosan gel preparation pH, characterized in that: said radiation sterilization is a Cobalt-60 sterilized.
CN 201310153544 2013-04-28 2013-04-28 Irradiation degradation-resistant and pH-adjustable chitosan gel and preparation method thereof CN104119577A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572906A (en) * 1983-11-21 1986-02-25 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Chitosan based wound dressing materials
CN1954817A (en) * 2005-10-28 2007-05-02 中国科学院过程工程研究所 Preparation method of injection type pH and glucose sensitive hydrogel
CN101148520A (en) * 2007-10-19 2008-03-26 浙江大学 Temperature sensitive chitosan hydrogel
CN103040728A (en) * 2013-02-03 2013-04-17 福州乾正药业有限公司 Chitosan gel for women as well as preparation method and medical application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572906A (en) * 1983-11-21 1986-02-25 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Chitosan based wound dressing materials
CN1954817A (en) * 2005-10-28 2007-05-02 中国科学院过程工程研究所 Preparation method of injection type pH and glucose sensitive hydrogel
CN101148520A (en) * 2007-10-19 2008-03-26 浙江大学 Temperature sensitive chitosan hydrogel
CN103040728A (en) * 2013-02-03 2013-04-17 福州乾正药业有限公司 Chitosan gel for women as well as preparation method and medical application thereof

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