CN104055708A - Anti-inflammatory cosmetic composition and preparation method thereof - Google Patents
Anti-inflammatory cosmetic composition and preparation method thereof Download PDFInfo
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- CN104055708A CN104055708A CN201410319713.4A CN201410319713A CN104055708A CN 104055708 A CN104055708 A CN 104055708A CN 201410319713 A CN201410319713 A CN 201410319713A CN 104055708 A CN104055708 A CN 104055708A
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 33
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- 238000002360 preparation method Methods 0.000 title claims description 7
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- 239000002253 acid Substances 0.000 claims description 9
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- 238000002156 mixing Methods 0.000 claims description 8
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- 238000000605 extraction Methods 0.000 claims description 6
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- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 2
- 238000009413 insulation Methods 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229940057910 shea butter Drugs 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 229960001295 tocopherol Drugs 0.000 claims description 2
- 229930003799 tocopherol Natural products 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- 125000002640 tocopherol group Chemical group 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 abstract description 7
- 239000000419 plant extract Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 abstract 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 241000544066 Stevia Species 0.000 abstract 2
- 239000011259 mixed solution Substances 0.000 abstract 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 abstract 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
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- 239000004744 fabric Substances 0.000 description 3
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- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 240000007163 Livistona chinensis Species 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an anti-inflammatory cosmetic composition. The anti-inflammatory cosmetic composition comprises, by weight, 1-15 parts of plant extracts, 2.55-7 parts of emulsifying agents, 4-26 parts of emollient, 2.5-20 parts of humectant, 0.1-0.3 part of dipotassium glycyrrhizinate, 0.1-2 parts of silica, 0.03-0.07 part of potassium hydroxide, 0.1-0.2 part of a thickening agent, 0.05-2 parts of antioxidants, 0.201-1.01 parts of preservatives and 40-75 parts of water. The plant extracts are mixed solutions of stevia extracting solutions and palm leaf extracting solutions. The mixed solutions of the stevia extracting solutions and the palm leaf extracting solutions are applied to anti-inflammatory cosmetics, so that the dermatitis is effectively prevented and treated.
Description
Technical field
The present invention relates to cosmetic field, particularly relate to a kind of cosmetic composition with anti-inflammatory properties and preparation method thereof.
Background technology
Cosmetics are to smear, spray or other similar methods, impose on any position of human body surface (skin, fingernail, lip, the ripe film in oral cavity etc.), with the product that reaches clean, eliminates bad smell, skin protection, beauty treatment and modification object.
Along with social progress, the continuous improvement of working environment, increasing people can work under comfortable air conditioner surroundings.Yet, in air-conditioned room, be easy to grow a large amount of antibacterials.Wherein legionella pneumophilia is the pneumonia antibacterial that is active in air-conditioned room, and it has the infection of unknown cause to skin, causes the inflammation of skin, makes skin occur the symptoms such as erythema, pruritus.This will have influence on people's external image, can have influence on what is more people's orthobiosis.
Along with the development of cosmetics industry, natural plants series products due to use safety, action temperature and, the advantage such as successful welcome.Be generally to obtain by corresponding processing the plant extract that contains effective ingredient, and add in cosmetics.
At present, antiinflammatory cosmetics antiphlogistic effects is on the market not obvious, and very easily causes allergic phenomena.Therefore, selecting which kind of plant, and being applied in cosmetics of its safety reached to better antiphlogistic effects, is problem demanding prompt solution.
Summary of the invention
Based on this, the object of the present invention is to provide a kind of antiinflammatory cosmetic composition.
Concrete technical scheme is as follows:
An antiinflammatory cosmetic composition, is characterized in that, by weight, comprises following component:
Wherein, described plant extraction liquid is the mixed liquor of Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution.
In an embodiment, the weight portion of described plant extraction liquid is 5～12 parts therein; The weight part ratio of described Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution is (0.5～10): (0.5～10).
In an embodiment, the weight part ratio of described Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution is (2～10): (2～10) therein.
In an embodiment, described thickening agent is carbomer therein; Described antioxidant is tocopherol.
In an embodiment, described emulsifying agent is that weight part ratio is (1～3): (1～3): (0.5～3) therein: the smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis of (0.05～2), the smooth olive oil acid esters of the smooth cetylate/Pyrusussuriensis of spermol cetylate/Pyrusussuriensis, cetearyl alcohol and stearic mixing.
In an embodiment, described emollient is that weight part ratio is (1～5): (0.5～5): (0.5～5): (1～5): (0.5～5): the mixing of the shea butter of (0.5～2), olive oil, caprylic/capric triglyceride, squalane, ring five polydimethylsiloxane and polydimethylsiloxane therein.
In an embodiment, described wetting agent is that weight part ratio is (1～10): (1～10): (0.1～3): the mixing of the glycerol of (0.01～0.1), butanediol, trehalose and hyaluronate sodium therein.
In an embodiment, described antiseptic is that weight part ratio is (0.2～1): the phenoxyethanol of (0.001～0.01) and the mixing of Methylisothiazolinone therein.
Flos Chrysanthemi extracting solution of the present invention and Folium Trachycarpi extracting solution can be prepared by conventional alcohol extracting method, with this, guarantee to greatest extent the anti-inflammatory efficacy of two kinds of extracting solution, preferred following extracting method: it is in 85% ethanol that dry plant (Flos Chrysanthemi or Folium Trachycarpi) is joined to mass ratio, reflux and flood under extract 4～8h.Subsequently, with filter cloth, extracting solution is filtered, more centrifugalize obtains plant (Flos Chrysanthemi or Folium Trachycarpi) extracting solution.
The preparation method of above-mentioned antiinflammatory cosmetic composition, comprises the steps:
(1) emollient, emulsifying agent and antioxidant are dropped into oil phase pot, be heated to 70～85 ℃, wait all components to melt rear insulation, obtain A phase;
(2) wetting agent, Silicon stone, thickening agent, glycyrrhizic acid dipotassium and water are dropped into emulsifying pot, be heated to 70～85 ℃, be incubated 15～30 minutes, obtain B phase;
(3) by the emulsifying pot of the A phase suction step (2) in step (1), homogenizing 3～15 minutes, stir speed (S.S.) is 2000～4000rpm, and then insulated and stirred is 15～45 minutes, and stir speed (S.S.) is 20～40rpm;
(4) emulsion in step (3) is cooled to 40～45 ℃, adds sodium hydroxide, stir;
(5) add plant extraction liquid and antiseptic, stir, obtain antiinflammatory cosmetic composition.
Flos Chrysanthemi be Compositae this than subgenus herbaceos perennial, have another name called Folium Stevlae Rebaudianae.Oman that Flos Chrysanthemi original producton location joins in South America Paraguay northeast and Brazilian border is visitd in mountain range.All introduce a fine variety on the ground such as existing Beijing, Hebei, Shaanxi, Jiangsu, Fujian, Hunan, Yunnan.Legionella pneumophilia can cause the baffled skin infection under air conditioner surroundings, and Flos Chrysanthemi extract has inhibition to legionella pneumophilia, in antiinflammatory cosmetic composition of the present invention, adds the effect that Flos Chrysanthemi extract has good prevention and cure dermatitis.
Folium Trachycarpi is the leaf of Petiolus Trachycarpi.Petiolus Trachycarpi has another name called Tang palm fibre, Chinese fan palm fibre, spells palm fibre, is the long green arbor of Palmae Trachycarpus, and it originates in Chinese Central-South mountain region, is the most cold-resistant Petiolus Trachycarpi, and except China, many countries introduce a fine variety in the world.Folium Trachycarpi extract also has inhibition to legionella pneumophilia, in antiinflammatory cosmetic composition of the present invention, adds the effect that Folium Trachycarpi extract has good prevention and cure dermatitis.
The glycyrrhizic acid dipotassium adding in antiinflammatory cosmetic composition of the present invention has good antiinflammatory antiallergic effect, can neutralize or lower the noxious substance of cosmetics, prevent anaphylaxis, share and can accelerate skin to their absorption and potentiation with emollient, wetting agent.
The emollient energy moistening skin adding in antiinflammatory cosmetic composition of the present invention, lubricated skin, protection and softening skin, and can improve the time of staying of moisture in skin; The effect of wetting agent is to form thin film at skin surface, and moisture content is sealed in skin to prevent water evaporates, does not hinder skin for the absorption of water in air part, thereby keeps the suitable humidity of skin simultaneously.
The following composition title that the application occurs is the title of INCI (InternationalNomenclaure Cosmetic Ingredient, i.e. international cosmetic raw material name) defined: the smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis, the smooth olive oil acid esters of the smooth cetylate/Pyrusussuriensis of spermol cetylate/Pyrusussuriensis and caprylic/capric triglyceride.
Advantage of the present invention is as follows:
Compared with prior art, antiinflammatory cosmetic composition of the present invention prevention and cure dermatitis effectively.
The specific embodiment
Below in conjunction with specific embodiment, present techniques scheme is described further.
The preparation of Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution:
It is in 85% ethanol that dry Flos Chrysanthemi is joined to mass ratio, reflux and dipping under extract 6h.Subsequently, with filter cloth, extracting solution is filtered, then under rotating speed 3000r/min, centrifugalize 30 minutes, obtains Flos Chrysanthemi extracting solution.
It is in 85% ethanol that dry Folium Trachycarpi is joined to mass ratio, reflux and dipping under extract 6h.Subsequently, with filter cloth, extracting solution is filtered, then under rotating speed 3000r/min, centrifugalize 30 minutes, obtains Folium Trachycarpi extracting solution.
The formula of the antiinflammatory cosmetic composition of embodiment 1-3 and comparative example 1-3 is in Table 1.
Table 1
The formula of the antiinflammatory cosmetic composition of embodiment 4-6 and comparative example 4-6 is in Table 2.
Table 2
The formula of the antiinflammatory cosmetic composition of embodiment 7-9 and comparative example 7-9 is in Table 3.
Table 3
The formula of the antiinflammatory cosmetic composition of embodiment 10-12 and comparative example 10-12 is in Table 4.
Table 4
The cosmetics that above-described embodiment and comparative example make, through continuous the trying out 30 days of 100 personnel of 20～50 years old, the antiphlogistic effects of prepared cosmetics in the various embodiments described above was evaluated in relative analysis respectively.Wherein, described antiphlogistic effects is the improvement situation of erythema, pruritus, erythra, eczema etc., the results are shown in Table 5.
Table 5
The cosmetic composition of above-described embodiment 1-12 and comparative example 1-12 is not all found zest and allergic phenomena in process on probation.
As known from Table 5: in embodiment, each product is obviously high than the improvement degree of each product in matched group to the improvement degree of erythema, pruritus, erythra, eczema etc.; And the weight portion of Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution is larger, improvement degree is higher, at the mixed liquor weight portion of Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution, is 5～12 o'clock, and the cost performance of product is the highest.
The cosmetic composition of above-described embodiment 1-12 and comparative example 1-12 makes by following preparation method:
(1) above-mentioned A phase component is dropped into oil phase pot, be heated to 75 ℃, wait all components to melt rear heat preservation for standby use;
(2) above-mentioned B phase component is dropped into emulsifying pot, be heated to 80 ℃, be incubated 20 minutes;
(3) by step 1) in A phase suction step 2) emulsifying pot in, homogenizing (homogenizing stir speed (S.S.) is 3000rpm) insulated and stirred (stir speed (S.S.) is 30rpm) 25 minutes after 5 minutes;
(4) emulsion in step (3) is cooled to 40 ℃, adds above-mentioned C phase component, stir;
(5) add D phase and E phase component, stir, obtain the cosmetics of anti-inflammatory composition.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (9)
1. an antiinflammatory cosmetic composition, is characterized in that, by weight, comprises following component:
Wherein, described plant extraction liquid is the mixed liquor of Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution.
2. antiinflammatory cosmetic composition according to claim 1, is characterized in that, the weight portion of described plant extraction liquid is 5～12 parts; The weight part ratio of described Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution is (0.5～10): (0.5～10).
3. antiinflammatory cosmetic composition according to claim 2, is characterized in that, the weight part ratio of described Flos Chrysanthemi extracting solution and Folium Trachycarpi extracting solution is (2～10): (2～10).
4. according to antiinflammatory cosmetic composition described in claim 1-3 any one, it is characterized in that, described thickening agent is carbomer; Described antioxidant is tocopherol.
5. according to antiinflammatory cosmetic composition described in claim 1-3 any one, it is characterized in that, described emulsifying agent is that weight part ratio is (1～3): (1～3): (0.5～3): the smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis of (0.05～2), the smooth olive oil acid esters of the smooth cetylate/Pyrusussuriensis of spermol cetylate/Pyrusussuriensis, cetearyl alcohol and stearic mixing.
6. according to antiinflammatory cosmetic composition described in claim 1-3 any one, it is characterized in that, described emollient is that weight part ratio is (1～5): (0.5～5): (0.5～5): (1～5): (0.5～5): the mixing of the shea butter of (0.5～2), olive oil, caprylic/capric triglyceride, squalane, ring five polydimethylsiloxane and polydimethylsiloxane.
7. according to antiinflammatory cosmetic composition described in claim 1-3 any one, it is characterized in that, described wetting agent is that weight part ratio is (1～10): (1～10): (0.1～3): the mixing of the glycerol of (0.01～0.1), butanediol, trehalose and hyaluronate sodium.
8. according to the cosmetics of anti-inflammatory composition described in claim 1-3 any one, it is characterized in that, described antiseptic is that weight part ratio is (0.2～1): the phenoxyethanol of (0.001～0.01) and the mixing of Methylisothiazolinone.
9. a preparation method for antiinflammatory cosmetic composition described in claim 1-9 any one, is characterized in that, comprises the following steps:
(1) emollient, emulsifying agent and antioxidant are dropped into oil phase pot, be heated to 70～85 ℃, wait all components to melt rear insulation, obtain A phase;
(2) wetting agent, Silicon stone, thickening agent, glycyrrhizic acid dipotassium and water are dropped into emulsifying pot, be heated to 70～85 ℃, be incubated 15～30 minutes, obtain B phase;
(3) by the emulsifying pot of the A phase suction step (2) in step (1), homogenizing 3～15 minutes, stir speed (S.S.) is 2000～4000rpm, and then insulated and stirred is 15～45 minutes, and stir speed (S.S.) is 20～40rpm;
(4) emulsion in step (3) is cooled to 40～45 ℃, adds sodium hydroxide, stir;
(5) add plant extraction liquid and antiseptic, stir, obtain antiinflammatory cosmetic composition.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105816395A (en) * | 2016-05-25 | 2016-08-03 | 广州丹奇日用化工厂有限公司 | Oil-control anti-acne cosmetic containing enoki mushroom extract and preparation method of oil-control anti-acne cosmetic |
| CN106726987A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of inhibiting bacteria and diminishing inflammation composition and its application |
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| JPH08325156A (en) * | 1995-06-01 | 1996-12-10 | Ichimaru Pharcos Co Ltd | Skin preparation for external use, drink and food product containing steviol glycoside |
| CN101048201A (en) * | 2004-10-25 | 2007-10-03 | 科蒂·普雷斯蒂奇·兰开斯特集团有限公司 | Moisture-regulating cosmetic |
| CN103040680A (en) * | 2012-12-06 | 2013-04-17 | 郭民召 | Composite of acne curing cream and beauty liquid |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH08325156A (en) * | 1995-06-01 | 1996-12-10 | Ichimaru Pharcos Co Ltd | Skin preparation for external use, drink and food product containing steviol glycoside |
| CN101048201A (en) * | 2004-10-25 | 2007-10-03 | 科蒂·普雷斯蒂奇·兰开斯特集团有限公司 | Moisture-regulating cosmetic |
| CN103040680A (en) * | 2012-12-06 | 2013-04-17 | 郭民召 | Composite of acne curing cream and beauty liquid |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105816395A (en) * | 2016-05-25 | 2016-08-03 | 广州丹奇日用化工厂有限公司 | Oil-control anti-acne cosmetic containing enoki mushroom extract and preparation method of oil-control anti-acne cosmetic |
| CN106726987A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of inhibiting bacteria and diminishing inflammation composition and its application |
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| CN104055708B (en) | 2017-02-15 |
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