CN104055600A - Repairing system provided with anchoring device and used for preventing valve regurgitation - Google Patents

Repairing system provided with anchoring device and used for preventing valve regurgitation Download PDF

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CN104055600A
CN104055600A CN 201410316922 CN201410316922A CN104055600A CN 104055600 A CN104055600 A CN 104055600A CN 201410316922 CN201410316922 CN 201410316922 CN 201410316922 A CN201410316922 A CN 201410316922A CN 104055600 A CN104055600 A CN 104055600A
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member
anchor
means
anchoring
distal end
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CN 201410316922
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Chinese (zh)
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CN104055600B (en )
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李佳楠
吕世文
徐志云
李毅斌
陈志�
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宁波健世生物科技有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457Chordae tendineae prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2463Implants forming part of the valve leaflets

Abstract

The invention relates to a repairing system provided with an anchoring device and used for preventing valve regurgitation. The system comprises a prosthesis preventing valve regurgitation and an anchoring part releasing device, wherein the prosthesis preventing valve regurgitation comprises a fixing unit, a connecting part and a close-assisting part, the fixing unit comprises a fixing part and an anchoring part, the connecting part is flexible, and the fixing part is fixed through the anchoring part, an anti-disengagement end is arranged at the near end of the anchoring part; the anchoring part releasing device comprises a delivery pipe and a push rod and is detachably connected with the fixing unit, the far end of the anchoring part releasing device is in a preset shape to enable the far end of the delivery pipe to be bent integrally or partially, a rigid section is arranged at the farthest end of the delivery pipe, the anchoring part is pre-arranged in the far end of the delivery pipe, the push rod is placed in the delivery pipe and located at the near end of the anchoring part, the anchoring part can be made to move towards the far end of the delivery pipe by pushing the push rod, and the far end of the anchoring part can recover to the preset shape after being pushed out of the delivery pipe.

Description

技术领域: FIELD:

[0001] 本发明属于医疗器械领域,具体涉及一种带锚定装置的用于阻止瓣膜反流的修复系统。 [0001] The present invention belongs to the field of medical devices, particularly to an anchoring device with valve repair system for preventing regurgitation. 一种带锚定装置的用于阻止瓣膜反流的修复系统 A tape anchoring means for preventing regurgitation valve repair system

背景技术: Background technique:

[0002] 二尖瓣位于左房室口,由瓣环、瓣叶、腱索、乳头肌、交界连接五部分组成,其在解剖学上的准确名称为二尖瓣装置(mitral apparatus)或者二尖瓣复合体(mitral complex)〇 [0002] The mitral valve is located in the left atrioventricular opening, the annulus, valve leaflets, chordae tendineae, papillary muscles, connecting the junction of five parts, which anatomically accurate name mitral apparatus (mitral apparatus) or di cusps complex (mitral complex) square

[0003] 三尖瓣位于右房室口,具有三片近似三角形的帆状瓣膜,瓣膜底附着于房室口的纤维环上,在功能上可视纤维环、瓣膜、腱索和乳头肌,为三尖瓣复合体(tricuspid valvar complex)〇 [0003] tricuspid valve in the right atrioventricular opening, having three approximately triangular sail valve, the valve is attached to the bottom of the atrioventricular orifice annulus, annulus on the visual function, the valve, chordae tendineae and papillary muscles, tricuspid complex (tricuspid valvar complex) square

[0004] 二尖瓣反流(mitral regurgitation)可以分为以下三种:功能性、退行性和混合性。 [0004] Mitral regurgitation (mitral regurgitation) can be divided into the following three: functional, degenerative and mixed. 最常见的是退行性与功能性二尖瓣反流。 The most common is functional and degenerative mitral regurgitation. 功能性一般为继发于左室壁运动功能受损、左室扩张、乳头肌功能异常,一般见于心力衰竭患者中。 Functional usually secondary to left ventricular wall motion dysfunction, left ventricular dilatation, papillary muscle dysfunction, usually found in patients with heart failure. 此部份患者也包括继发于冠心病的缺血性二尖瓣反流及非缺血性心肌病有关的二尖瓣反流。 This part also includes secondary to coronary artery disease in patients with ischemic mitral regurgitation and mitral related to non-ischemic cardiomyopathy reflux. 退行性二尖瓣反流疾病一般被认为是瓣膜结构发生病理性变化,或瓣膜下结构病理性改变,包括腱索的异常延展或是断裂。 Degenerative mitral regurgitation disease is generally considered to be pathological changes in structure of the valve, or a subvalvular pathological changes, comprising a tendon abnormality ductile or brittle. 二尖瓣关闭不全的详细病因可分为:1.冠状动脉粥样硬化性心脏病(冠心病):心肌梗塞后以及慢性心肌缺血累及乳头肌及其邻近室壁心肌,引起乳头肌纤维化伴功能障碍;2.先天性畸形:二尖瓣裂缺,最常见于心内膜垫缺损或纠正型心脏转位、心内膜弹力纤维增生症、 降落伞型二尖瓣畸形;3.二尖瓣环钙化:为特发性退行性病变,多见于老年女性患者。 The detailed etiology of mitral regurgitation can be divided into: 1 coronary heart disease (CHD): after infarction and chronic myocardial ischemia involving the papillary muscles and adjacent ventricular wall, causing papillary muscle fibrosis with dysfunction; 2 congenital malformations: cleft mitral valve, most commonly in the endocardial cushion defect or corrective heart translocation, endocardial elastic fibers hyperplasia, parachute mitral deformity; 3 mitral valve. annular calcification: idiopathic degenerative disease, more common in older women. 此夕卜,高血压病,马凡综合征,慢性肾功能衰竭和继发性甲状腺功能亢进的患者,亦易发生二尖瓣环钙化;4.左心室扩大:任何病因引起的明显左心室扩大,均可使二尖瓣环扩张,和乳头肌侧移,影响瓣叶的闭合,从而导致二尖瓣关闭不全;5.二尖瓣脱垂综合征;6.其他少见病因:结缔组织病如系统性红斑狼疮,类风湿性关节炎等;肥厚梗阻型心肌病;强直硬化性脊椎炎。 Bu this evening, hypertension, Marfan syndrome, patients with chronic renal failure and secondary hyperthyroidism, is also prone to mitral annular calcification; 4 left ventricular enlargement: significant expansion of the left ventricle due to any cause , can make the mitral annulus dilatation, papillary muscle and lateral impact of the leaflets closed, leading to mitral regurgitation; 5 syndrome, mitral valve prolapse; 6 other rare causes: connective tissue diseases such systemic lupus erythematosus, rheumatoid arthritis; hypertrophic obstructive cardiomyopathy; sclerosing tonic spondylitis. 对于二尖瓣关闭不全,在美国和西方发达国家,粘液性退行性病变引起的占主要地位,约45 %〜65 %,而风湿性病变仍是许多发展中国家二尖瓣病变的主要原因,约占80 %。 For mitral regurgitation, developed in the United States and the West, dominated mucinous degeneration caused about 45% ~ 65%, while the disease remains the leading cause of rheumatic mitral valve disease in many developing countries, accounting for about 80%.

[0005] 三尖瓣反流一般为肺动脉高压,右室扩大,三尖瓣环扩张引起,出现三尖瓣反流后,乏力、腹水、水肿、肝区疼痛、消化不良、纳差等右心衰症状加重。 [0005] Usually tricuspid regurgitation pulmonary hypertension, right ventricular dilatation, tricuspid annulus caused by dilation, after the emergence of tricuspid regurgitation, fatigue, ascites, edema, liver pain, dyspepsia, anorexia and other right heart failure symptoms. 三尖瓣关闭不全主要分为功能性三尖瓣关闭不全和器质性三尖瓣关闭不全。 Tricuspid regurgitation is divided into functional tricuspid regurgitation and organic tricuspid regurgitation. 由风湿热引起的瓣膜的器质性关闭不全为数很少,多数为功能性关闭不全,其最常见的病因是由肺动脉高压造成右心室扩张,三尖瓣环扩大,导致三尖瓣相对关闭不全而瓣膜本身结构正常。 Rheumatic fever caused by organic valvular regurgitation very few, most of regurgitation is functional, the most common cause of pulmonary hypertension caused by right ventricular dilatation, expansion of the tricuspid annulus, resulting in tricuspid regurgitation relative The valve itself is a normal structure.

[0006] 二尖瓣反流和三尖瓣反流的传统治疗手段包括适用于轻度至重度反流的药物治疗,和有相对应手术指征的外科手术方法。 Traditional treatment [0006] mitral regurgitation, tricuspid regurgitation and includes drug treatment for mild to severe reflux, and surgical methods have corresponding indications for surgery. 其中,外科手术方法还包括二尖瓣、三尖瓣置换和二尖瓣、三尖瓣修补。 Wherein the method further comprises surgical mitral and tricuspid valve replacement mitral valve, tricuspid valve repair. 单纯的二尖瓣反流,需要二尖瓣置换的病人只有30%,余下的只需要二尖瓣修补。 Pure mitral regurgitation, mitral valve replacement patients need only 30%, the remainder of only mitral valve repair. 在外科手术方法中,典型的开胸、开心手术侵入性过大,需要建立体外循环, 具有较高的并发症发生率和感染风险。 In the surgical approach, typical thoracotomy, invasive heart surgery is too large, the need for cardiopulmonary bypass, with high morbidity and risk of infection. 而为了降低手术风险,经导管介入的置换和修补手术方法得以发展。 In order to reduce the risk of surgery, transcatheter intervention of replacement and repair surgery method to develop.

[0007] 根据文献【Enriquez-Sarano M,Schaff HV,Orszulak TA,et al. Valve repair improves the outcome of surgery formitral regurgitation :a multivariate analysis [J] · Circulation,1995,91 (4) : 1022-1088】报导可见置换术具有较高的总手术病死率和较低的生存率。 [0007] According to the literature [Enriquez-Sarano M, Schaff HV, Orszulak TA, et al Valve repair improves the outcome of surgery formitral regurgitation:. A multivariate analysis [J] · Circulation, 1995,91 (4): 1022-1088] visible reported total replacement surgery have a higher mortality and lower survival rates.

[0008] 表1.二尖瓣成形术与二尖瓣置换术术后病死率及并发症的比较(多中心) [0008] Table 1. Comparison mitral valvuloplasty with MVR postoperative complications and mortality (polycentric)

[0009] [0009]

[0010] 而经导管治疗瓣膜反流,目前亟待解决的问题有如下几点:尽可能在保证阻反流效果的前提下,减少植入物的植入量;阻反流的器械必须被准确定位并牢固固定在需要治疗的部位;阻反流的器械需要最小程度的影响剩余具有正常功能的瓣叶的运动;阻反流的器械需要适应瓣环的生理结构的差异性,下面列举了目前现有技术中,不同的阻反流器械和锚定技术的技术要点。 [0010] treatment and the transcatheter valve regurgitation, present problems to be solved are the following: to ensure as far as possible under the premise blocking effect regurgitation, reduce the amount of implantation of the implant; blocking regurgitation instrument must be accurately positioned and fixedly secured site in need of treatment; instrument blocking regurgitation requires minimal impact residual motion leaflet with normal function; instrument blocking regurgitation need to accommodate differences in the physical structure of the annulus, below lists the current in the prior art, various techniques of blocking devices and reflux anchoring techniques.

[0011] 专利W02006037073A2描述了一种使用二尖瓣夹(mitral clip)进行二尖瓣修补的治疗方法,将二尖瓣膜的中心或者角落区域缝合在一起,但此技术无法应用于以下两类患者:收缩期瓣叶间接缝间隙> l〇mm,无法准确同步两个瓣叶活动;另一种是瓣环下的结构有严重增厚与钙化,因腱索、瓣叶、瓣环压力的提高,有腱索断裂的风险。 [0011] Patent W02006037073A2 describes a mitral clip (mitral clip) for treatment of mitral valve repair, mitral valve will be sewn together or the central corner regions, but this technique can not be applied to the following types of patients : clearance of joints systolic leaflet> l〇mm not accurately synchronize two leaflets activity; the other is a configuration in severe thickening of the annulus calcification, because tendons, leaflets, annulus pressure increase there is a risk of tendon rupture.

[0012] 专利US20130023985描述了一种用于治疗瓣膜关闭不全和其他瓣膜疾病的植入物、植入系统和方法,所述的植入物包括一个辅助瓣叶接合体,所述瓣叶接合体上部贴合自体瓣环部分的长度为25-35mm,等于第一和第二联合交界处之间的距离,所述瓣叶接合体上部到下部长度50-60mm,并且在所述瓣叶接合体上可选择的设置有锚定装置,在其权利要求中,还限制了所述接合体的某一部分为圆锥形,在另一个权利要求中,除了限定所述上部贴合自体瓣环部分长度为25-35mm,还限定了所述瓣叶接合部分与瓣环垂直方向的高度为35-45mm,限定了心室未接合部分在与瓣环垂直方向上的高度为25-35mm,限定了接合部分弧度半径在35-45mm以内。 [0012] Patent No. US20130023985 describes an implant for the treatment of valvular insufficiency and valvular diseases other implant systems and methods, the implant comprises a secondary flap assembly, the leaflet assembly bonded to the upper annulus portion of the length of 25-35 mm from the body, equal to the distance between the first and second joint at the junction of the upper body flap connected to the lower length of 50-60mm, and the leaflet assembly Alternatively the anchoring means is provided, in its claim, further limiting the access of a portion of the body is conical, in other claims, except as defined bonded to the upper annulus portion autologous length 25-35 mm, further defines a height of the leaflet portion of the annulus is perpendicular to the direction of engagement 35-45mm defining the height of the ventricular portion of the annulus in the vertical direction of 25-35 mm is not engaged, the engagement portion defining a curvature within a radius of 35-45mm. 该种系统对于上部贴合自体瓣环部分的长度限制,只适用于二尖瓣前瓣或者后瓣脱垂的整体修复,以及部分三尖瓣的整体瓣叶的脱垂修复,并且表明所述接合体下部长度至少覆盖了大部分瓣叶,所述结合部分具有特定的弧度要求。 This kind of system is attached to the upper length limit native annulus from the engagement portion, only applicable to anterior mitral valve prolapse or entirely after the repair, and the entire leaflet prolapse repair the tricuspid valve portion, and indicates that the a lower assembly length to cover at least most of the leaflets, the binding moiety having specific requirements arc. 该种技术无法适应瓣膜小部分脱垂或者较小瓣膜例如主动脉瓣的修复,在修复关闭不全的位置时, 同时牺牲了其余正常工作的瓣膜。 This kind of technology can not adapt to a small portion of the valve prolapse or less valvular aortic valve repair for example, in the repair of regurgitation position, at the expense of the rest of the normal operation of the valve.

[0013] 而在专利CN103338726A中,描述了一种用于治疗患者心脏瓣膜的接合不良的方法,所述方法包括在植入物处于第一构型时将所述植入物引入心脏中,将所述植入物在心脏内从所述第一构型展开成第二构型,处于所述第二构型的所述植入物具有第一和第二相反的接合表面的接合辅助体,以及支持所述展开的植入物使得所述接合辅助体沿所述接合区从所述心脏瓣膜的所述轴线偏移,在其权利要求中,所述方法还包括:在靠近所述第一联合(所述第一联合为在所述心脏瓣膜具有的第一和第二瓣叶的第一连接处)的第一目标位置处选择性地配置第一锚定件,在靠近所述第二联合(所述第二联合为在所述心脏瓣膜具有的第一和第二瓣叶的第二连接处)的第二目标位置处选择性地配置第二锚定件,将接合辅助体引入心脏中,在另一个权利要求中,描述了所述植 [0013] In the patent CN103338726A, joining failure is described a method for treating a patient's heart valve, said method comprising the implant is in the first configuration, the implant is introduced into the heart, the the implant is deployed within the heart from the first configuration to the second configuration, in said second configuration said implant having opposite first and second auxiliary body engagement surface, and supporting the deployed implant such that the engagement member engages in the auxiliary region of the heart valve from the offset axis, in its claims, the method further comprising: in the first near joint (the first joint is a first and a first connector at a second leaflet of the heart valve having a) at a first target position is selectively disposed a first anchor member proximate the second at a second target position (the second joint of the second connection heart valve having a first and a second flap) is arranged to selectively combined second anchor member, will engage the auxiliary body introduced into the heart , the other claims, the implant is described 入物包括接合辅助体、第一锚定件和第二锚定件,所述接合辅助体具有轴线以及第一和第二相反的主接合表面,各接合表面在所述接合辅助体的第一横向边缘与第二横向边缘之间横向延伸,所述第一锚定件可选择性的配置在靠近所述第一联合的心脏的第一目标位置处,使得所述第一横向边缘朝向所述第一联合定向,其后还限定了所述第二锚定件的锚定位置在靠近所述第二联合处。 Engaging the auxiliary body comprises a first anchoring member and second anchoring member engaging said auxiliary body having a first axis and a surface opposite to the first and second primary engaging surface, each of said engaging member engaging the auxiliary extending transversely between the lateral edges and second lateral edges, the first anchoring member is selectively disposed at a position close to the first target of a first joint of the heart, such that the first lateral edge towards the a first joint orientation, followed by further defines a second anchor position of the anchor adjacent to the joint at the second. 在另一个权利要求中,还特别限定了所述植入物的轴线需沿所述瓣膜轴线延伸,并且所述接合辅助体的第一和第二侧边需沿所述心脏瓣膜的接合区的曲线延伸,其中被支持的植入物的所述接合辅助体充分横向适形,所述植入物与心脏之间的接合使得所述边缘之间的所述接合辅助体朝向所述心脏瓣膜的接合区所限定的曲线横向弯曲。 In the other claims, further defines the particular needs of the implant axis thereof along an axis extending in the valve, and the engagement region first and second sides of the auxiliary body in need of a heart valve curve extends, wherein the implant is supported auxiliary body engaging transverse sufficiently conformal, engagement between the implant and the heart was such that the engagement between the auxiliary body towards the edge of the heart valve lands defined lateral bending curve. 上述权利要求,限定了所述锚定位置需为靠近所述第一以及第二联合处,还限定了整个所述接合辅助体需与所述心脏瓣膜充分横向适形。 The preceding claims, defining the anchoring position must be a close joint at the first and second further defines the entire body of the auxiliary engagement with the heart valve for an adequate lateral conformable. 此种技术,无法适应部分的瓣膜脱垂症,在发挥阻反流效果的同时,具有两个缺点,第一,覆盖了未脱垂的正常瓣膜,在长期的运动过程中,容易造成粘连,牺牲了部分正常瓣膜的正常功能运作;第二,在靠近自体瓣环处的自体瓣叶部分,在开闭过程中,运动幅度比靠近瓣尖处的瓣叶部分的运动幅度小,容易与被充分横向适形并与其相贴的所述心脏瓣膜辅助体发生粘连,此处不同于所述的上部接合辅助体即瓣环处,在所述的瓣环处, 在长期的植入过程中,植入物应该与所述的自体瓣环生长在一起,增加被固定的效果,而所述的靠近自体瓣环处的自体瓣叶部分,一旦造成粘连,会影响瓣叶的运动效果,容易造成二次反流,导致阻反流治疗失败;第三,由于各人自体瓣环的尺寸各异,导致本技术中产品规格较多。 This technique can not adapt to the valve prolapse portions, while play reflux blocking effect, has two disadvantages, first, the cover is not properly valve prolapse, long-term movement, likely to cause blocking, sacrifice the normal function of the operating part of the normal valve; a second, near from the leaf portion native valve body the valve annulus, the opening and closing process, the amplitude of motion is smaller than the amplitude of motion near the leaflet portion of the valve at the tip easily and are sufficiently conformable and transverse thereto affixed to the heart valve auxiliary body adhesions, here is different from said upper engaging i.e. the auxiliary body at the annulus, the annulus, the long-term implantation, the implant should the native valve ring grow together, increasing the anchor effect, and the portion of the leaflet from the body member from the annulus at the close, once cause adhesions, leaflet will affect the exercise effect, likely to cause secondary reflux, leading to treatment failure resistance reflux; third, since everyone from different annulus sizes body, leading to higher product specifications this art.

[0014] 专利US20130325110A1描述了一种不停跳输送助瓣叶关闭假体的治疗二尖瓣和三尖瓣反流的方法,所述的方法包括利用柔性轨道,将心室固定件从心房穿过自体瓣膜送入右心室进行锚定,利用导管输送并调整所述假体在三尖瓣环的位置,直至使反流减小,将所述导管与所述柔性轨道相对固定,并固定在下腔静脉上。 [0014] Patent No. US20130325110A1 describes a beating method of treating a conveyor co leaflet mitral and tricuspid regurgitation prosthesis closure, said process comprising using a flexible track, the ventricle from the atrium through the fixing member native valve into the right ventricle anchoring by adjusting the position of the catheter delivery and prosthesis tricuspid annulus until reflux is reduced so that, the flexible conduit and the relatively fixed rail, and fixed to the lower chamber vein. 该种输送方法虽可以调节所述假体的位置以适应不同的反流位置,有一定的病变适应性,但是所述的在下腔静脉的固定位置远离瓣环位置,容易导致固定不牢固,假体在固定完毕后位移。 Although this type of delivery method may adjust the position of the prosthesis to accommodate different positions of reflux, a certain adaptation of the lesion, but the fixed position of the inferior vena cava in a position away from the annulus, easily lead is not firmly fixed, false after the completion of the fixed displacement.

[0015] 专利US2005107811A1和US2008058868A1描述了一种锚定系统及其输送方法,采用形状记忆合金制成的锚针,该锚针具有双脚,双脚向同一方向转弯交叉,形成一个闭合环,该锚针配有展开构件和输送构件,且这两部件可互相转换,在手术过程中,将锚针从输送构件中释放,使得形状记忆合金自膨胀进入展开构件,从而使得锚针双脚能沿着锚针曲线方向扎入组织,进行组织固定。 [0015] Patent US2005107811A1 and US2008058868A1 describes an anchoring system and a transfer method using the anchor pin made of a shape memory alloy, which has a needle anchoring feet, legs intersecting turn in the same direction, form a closed loop, the anchor deployment needle member and with a conveying member, and the two components may be interchangeable, the anchor pin is released from the conveying member during the procedure, so that the shape memory alloy member into the deployed self-expanding, such that the anchor legs can move along the needle the direction of the anchor bar graph needle into the tissue, a tissue fixation. 该种锚定系统及其输送方法,仅仅采用了形状记忆合金本身的力扎入组织,对于例如部分带有心内膜等韧性组织的扎入部位,存在着扎入力不够,容易在扎入过程中滑脱,扎入后固定不稳,容易脱落等问题。 This kind of anchoring system and a transfer method, using only the force of the shape memory alloy bar into the tissue itself, for example, part of the bar portion of toughness with endocardial tissue, there is not enough into the tie, the tie-in process is easy slippage, rolling into the unstable fixed, easy to fall off and so on.

[0016] 目前临床结果表明,并未有一款理想的治疗瓣膜反流的产品。 [0016] Current clinical results show that the product does not have an ideal treatment of valvular regurgitation. 主要原因在于二尖瓣瓣环、三尖瓣瓣环等具有特殊的生理结构,且在瓣环下方有复杂的生理环境,造成产品准确定位和固定非常困难。 Mainly due to the mitral annulus, tricuspid ring having special physiological structure and complex physiological environment below the annulus, resulting in accurate positioning and fixing the product is very difficult. 另外,瓣膜脱垂病变的程度与位置不同,例如部分病人为后瓣脱垂导致的关闭不全,部分病人为联合瓣病变导致的关闭不全等,以上所述技术在治疗病变位置关闭不全的同时,还干涉到了剩余正常二尖瓣的生理结构,病变适应性不足,且以上所述的锚定技术,并不能够达到简易操作和牢固固定的标准,综上所述,尽管以上所描述的技术在瓣膜修复上分别都有一定的效果,但是,在治疗瓣膜关闭不全的手术领域,亟需一种同时具备位置可调、定位准确、锚定时与器械配合良好、操作简便、且能够应对各种不同程度与位置病变的技术。 Further, different levels of the position valve prolapse disease, for example, some patients after failure caused by closing valve prolapse, for the joint part of the patient valve disease due to regurgitation, etc., while the techniques described above insufficiency in the closed position of the lesions treated, also it interferes with the normal physiology of the mitral valve remaining insufficient adaptability lesions, and the above-described anchoring technique, is not able to achieve simple operation and securely fixed standard, summary, although the techniques described above in the respective valve repair have some effect, but, in the field of surgical treatment of valvular insufficiency, along with a need for an adjustable position, positioning accuracy, good mating anchored to the instrument, easy to operate, and can cope with various the extent and location of the lesion technology.

发明内容: SUMMARY:

[0017] 本发明的目的是克服现有技术的限制,针对瓣膜部分脱垂,提出一种带锚定装置的用于阻止瓣膜反流的修复系统,本发明可实现位置可调、定位准确和牢固锚定,能够根据各种不同程度与位置的病变,调节假体位置,再进行定位和锚定,同时不易与患者瓣环附近的组织粘连。 [0017] The object of the present invention to overcome the limitations of the prior art, for the part of the valve prolapse, to provide a belt anchoring device for preventing regurgitation valve repair system, the present invention can realize an adjustable position, positioning accuracy, and rigidly anchored, it can be different according to the lesion degree position, adjusting the position of the prosthesis, and then positioning and anchoring, and at the same time easy adhesion annulus tissue near the patient.

[0018] 本发明的目的是通过以下技术方案实现的: [0018] The object of the present invention is achieved by the following technical solution:

[0019] -种带锚定装置的用于阻止瓣膜反流的修复系统,包括阻止瓣膜反流的假体和锚定件释放装置,所述阻止瓣膜反流的假体包括固定单元、连接件和助闭件,所述固定单元包括固定件和锚定件,所述连接件的远端部分与所述固定件的近端部分相连,所述连接件的近端部分与所述助闭件的远端部分相连,所述连接件为柔性,使得所述连接件以及与之相连的所述助闭件能够随着瓣叶的运动而运动,所述固定件通过所述锚定件被固定在患者心房壁上或者瓣环上,所述助闭件在自由状态时位于患者自体瓣叶之间,所述锚定件的远端部分具有预设的形状,所述锚定件的近端设置有防脱端;所述锚定件释放装置包括输送管和推杆,所述锚定件释放装置与所述固定单元可拆卸连接,所述锚定件释放装置的远端部分具有预设的形状,使得所述输送管的远端部分能 [0019] - species with anchoring means for preventing regurgitation valve repair system, comprising a prosthetic valve to prevent regurgitation of the release means and the anchoring member, said fixing means prevents the prosthetic valve regurgitation comprising a connecting member and co-closing member, the fixing unit comprises a fixing member and an anchoring member connected to the proximal portion of the distal end portion of the fixing member of the connector, a proximal end portion of the connecting member and the closing member co is connected to the distal end portion, said flexible connecting member, such that said connecting member and said closing member co-connected thereto with the movement of the flap can be moved, by the fixing member is fixed to the anchor member atrial wall in a patient or the annulus, the closure member co-located in the patient from the proximal end of the body between the valve leaflets, the distal end portion of said anchor member having a predetermined shape in a free state, the anchoring member is provided with a retaining end; said anchor release means comprises a delivery tube and a pusher, said anchor member and said release means fixing unit detachably connected to a distal end portion of a given anchor member having a predetermined release means shape, such that the delivery tube distal end portion can be 整体弯曲或部分弯曲,以便于在所述锚定件被移动之前所述输送管的最远端紧抵所述固定单元或者紧抵自体组织,在所述输送管的最远端设置有刚性段,所述锚定件以伸展状态被预先装入所述输送管的远端部分内, 所述推杆被放置在所述输送管内,所述锚定件位于所述推杆的远端,推动所述推杆能够使所述锚定件向所述输送管的远端移动,所述锚定件被推出所述输送管后,所述锚定件的远端部分能够恢复其预设的形状,所述锚定件将所述阻止瓣膜反流的假体固定在所述自体组织与所述锚定件的所述防脱端之间。 Partially curved or curved as a whole, so as to abut against the distal-most before the anchoring member is moved to said delivery tube tightly against the fixed unit or autologous tissue, the delivery tube is provided with a rigid distal most segment the anchoring member is pre-loaded in a stretched state within the distal end portion of the delivery tube, the plunger is disposed within the delivery tube, the distal end of the anchor member fixed in said push rod, push the push rod capable of moving the anchor member distally of the delivery tube, the anchor member is pushed after the predetermined delivery tube, the distal end portion of said anchor member to resume its preset shape the anchor prevents the prosthetic valve regurgitation is fixed between the self and the tissue anchor retaining said end.

[0020] 本发明的目的还可以通过以下的技术方案来进一步实现: [0020] The object of the present invention may be further achieved by the following technical solution:

[0021 ] 优选的,所述输送管能够弯曲的部分为弯曲段,所述输送管的最远端到所述输送管的所述弯曲段的最近端之间的长度大于或等于以患者自体瓣膜组织环的最小半径(所述自体瓣膜组织环的半径被定义为在瓣环截面方向,从瓣环到瓣环截面中心的距离)做的圆的周长的1/6。 [0021] Preferably, the delivery tube can be bent portion is a curved segment, the farthest end of the length of the duct between the curved section of the nearest end of the duct is greater than or equal to the patient's native valve the minimum radius of the ring of tissue (the tissue from native valve annulus radius is defined as the cross-sectional direction in the annulus, the valve ring from the center of the cross section to the distance ring lobes) 1/6 of the circumference of a circle made.

[0022] 优选的,所述固定件展开的宽度小于瓣膜组织环周长的2/3。 [0022] Preferably, the fixing member is smaller than the width of the expanded circumference of the annulus tissue 2/3.

[0023] 优选的,所述的助闭件的最大宽度小于单个所述自体瓣叶展开的最大宽度。 [0023] Preferably, the maximum width of the closing member co smaller than the maximum width of a single leaflet of the self-deployed.

[0024] 优选的,所述助闭件为单片、多片、筒状、袋状、柱状或球囊,或者所述助闭件为单片与多片的组合,或者所述助闭件为单片与筒状的组合,或者所述助闭件为单片与袋状的组合,或者所述助闭件为单片与柱状的组合,或者所述助闭件为单片与球囊的组合。 [0024] Preferably, the co-closing member as a single piece, multi-piece, tubular, bag-like, cylindrical or balloon, or the co-closing member as a single piece with a combination of multiple pieces, or the co-closing member cylindrical monolithic combination, or a combination of said closing member as a single piece with the aid of a bag-like, or a combination of the co-closing member is a single piece of columnar, or the closing member as a single piece with the help balloon The combination.

[0025] 更优选的,所述助闭件为网格结构,或者所述助闭片为高分子材料片或动物源性材料片,当所述助闭片为高分子材料片或动物源性材料片时,在所述助闭片上设置有孔。 [0025] More preferably, the co-closing member is a grid structure, or the closing sheet is a co-polymer sheet material or sheet materials of animal origin, when the closing sheet is a co-polymer material sheet or animal origin sheet material, provided with a hole in the sheet closing aid.

[0026] 优选的,所述助闭件的近端设置有展开装置,所述展开装置由金属丝或高分子线制成。 [0026] Preferably, the proximal end of the co-closing member is provided with a deployment means, the deployment means is made of a metal wire or a polymer wire.

[0027] 优选的,所述助闭件上连接有调整结构,所述调整结构为金属丝或高分子线,所述金属丝或所述高分子线的一端连接在所述助闭件上,所述金属丝或所述高分子线的另一端连接在心室或者心尖上,通过调整所述金属丝或所述高分子线的两端之间的距离,来调整所述助闭件的阻反流的效果。 [0027] Preferably, the co-closing structure is connected to the adjustment member, the adjustment structure is a metal wire or a polymer wire, one end of the wire or wires of the polymer is connected to the closure member co, the other end of the wire or cable is connected to the polymer or ventricular apex, by adjusting the distance between the ends of the wire or wires of the polymer, to adjust the anti-blocking member closing aid the effect of flow.

[0028] 优选的,所述锚定件与所述固定件连接,所述锚定件释放装置与所述固定单元的可拆卸连接通过所述锚定件与所述锚定件释放装置的可拆卸连接来实现。 [0028] Preferably, the anchor member is connected to the stationary member, the anchor member is detachably fixed to the fixing unit release means connected to the anchor member through the anchor release means may detachable connection is achieved.

[0029] 更优选的,所述锚定件与所述固定件为一体结构。 [0029] More preferably, the anchor member and the fixed member is a unitary structure.

[0030] 优选的,在所述助闭件和所述固定件之间具有供血液流过的通道。 [0030] Preferably, between said promoter and said closing member having a fixing member for passage of blood flows.

[0031] 优选的,所述连接件为片状、条状或丝状,或者所述连接件为上述结构的组合。 [0031] Preferably, the connecting member is a sheet, strip or wire, or the connecting member is a combination of the above structure.

[0032] 更优选的,所述连接件上设置有孔,所述孔为血液流过的通道。 [0032] More preferably, the connecting member is provided with a hole, the passage holes flowing blood.

[0033] 更优选的,所述连接件被部分覆膜,所述连接件没有被覆膜的部分为血液流过的通道。 [0033] More preferably, the connection member is partially covered, the channel portion of the blood flowing through the member is not connected to the film.

[0034] 更优选的,当所述连接件为单根的条状或者丝状时,所述连接件的两侧为血液流过的通道。 [0034] More preferably, when the connecting member is a single filament or strip, on both sides of said connecting member is blood flow through the passageway.

[0035] 优选的,所述固定件为柔韧性的高分子片或高分子网布,或者所述固定件具有骨架结构,所述骨架结构为形状记忆材料编织制成或者一体切割而成,所述骨架结构被部分或者被全部覆膜。 [0035] Preferably, the fixing member is a flexible sheet of polymer or polymer network fabric, or the fixing member having a skeleton structure, the skeleton structure is made of a shape memory material or knitted integrally cut from the said skeleton structure is completely or partially covered.

[0036] 优选的,所述输送管的所述刚性段的长度大于或等于所述锚定件的全长的十分之一。 [0036] Preferably, the length of the rigid section of the duct is greater than or equal to one tenth of the total length of the anchor. 更优选的,所述输送管的所述刚性段的长度大于或等于所述锚定件的全长的二分之一。 More preferably, the length of the rigid section of the duct is greater than or equal to one-half of the total length of the anchor.

[0037] 优选的,所述输送管的远端部分被预定形,使得所述推杆的远端部分能够随着所述输送管的被预定形的远端部分弯曲,或者所述推杆的远端部分被预定形,所述输送管的所述远端部分随所述推杆被预定形的形状弯曲,或者所述输送管和所述推杆的远端部分均被预定形,使得所述输送管的远端部分与所述推杆的远端部分一起弯曲。 [0037] Preferably, the distal end portion of the delivery tube is pre-shaped such that the distal end portion of the plunger can be bent with a predetermined shape of the delivery tube distal end portion, or said push rod the distal end portion is a predetermined shape of the distal end portion of the delivery tube with the push rod is bent a predetermined shape, or the delivery tube and the distal end portion of the push rod are pre-shaped such that the said distal end portion of the delivery tube is bent together with the distal portion of the pusher.

[0038] 更优选的,所述推杆由形状记忆合金丝、形状记忆合金管、高分子材料棒或高分子材料管中的一种或多种制成,所述推杆的远端部分被预定形,所述输送管的远端部分随所述推杆被预定形的形状弯曲。 [0038] More preferably, the pusher wire made of a shape memory alloy, a shape memory alloy pipe, rod polymer material or a polymer material made of one or more tubes, the distal end portion of the pusher the predetermined shape of the distal portion of the delivery tube with the push rod is bent in a predetermined shape.

[0039] 优选的,所述锚定件的所述防脱端由所述锚定件的近端进一步延伸绕制形成。 [0039] Preferably, the said anchor member proximal end by said retaining member extends further anchoring system is formed around.

[0040] 优选的,所述推杆与所述锚定件的所述防脱端可拆卸连接。 [0040] Preferably, the push rod is detachably connected to the anchor member of the retaining end.

[0041] 优选的,所述带锚定装置的用于阻止瓣膜反流的修复系统还包括支撑装置和支撑装置操作件,所述支撑装置操作件与所述支撑装置的近端固定连接,所述支撑装置的远端部分能够弯曲,使得所述支撑装置被释放后,所述支撑装置的所述远端部分抵住自体组织。 [0041] Preferably, the belt anchor means for preventing regurgitation valve repair system further comprises a support means and a support member operation of the device, the proximal end of the support member operating means is fixedly connected to the support means, the said distal end portion of the support means can be bent, such that the distal end portion of the rear of the support means is released, the support means against the autologous tissue.

[0042] 优选的,所述带锚定装置的用于阻止瓣膜反流的修复系统还包括支撑装置和输送系统,所述输送系统包括引导头、外鞘管、鞘芯和操作件,所述鞘芯被设置在外鞘管内,所述鞘芯的远端与所述引导头固定连接,所述鞘芯的近端与所述操作件固定连接,所述心脏瓣膜假体、所述锚定件释放装置和所述支撑装置均被设置在所述外鞘管与所述鞘芯之间,所述支撑装置的近端与所述输送系统的所述操作件固定连接,或者所述支撑装置的远端与所述输送系统的所述引导头固定连接,或者所述支撑装置的近端与所述输送系统的所述操作件固定连接并且所述支撑装置的远端与所述输送系统的所述引导头固定连接,当所述锚定件释放装置被释放时,所述支撑装置给予所述锚定件释放装置支撑力。 [0042] Preferably, the belt anchor means for preventing regurgitation valve repair system further comprises a support means and a delivery system, the delivery system includes a guide head, the outer sheath, the core and the sheath operating member, said sheath-core is disposed within the outer sheath, the distal end of the sheath to the core is fixedly connected with the guide head, the proximal end of the sheath and the core of the operating member is fixedly connected to the heart valve prosthesis, the anchoring member releasing said operating member means and said support means are provided in the outer sheath between the core and the sheath, the proximal end of the support means and fixedly connected to the delivery system, or said support means said operating member is fixedly connected to the distal end of the delivery system with a fixed guide head is connected, or the proximal end of the delivery system and the support means and the distal end of the delivery system of the support means said guide head is fixedly connected to the anchor member when the release means is released, the supporting means anchoring device supporting force administering to said fixed member is released.

[0043] 同现有技术相比,本发明的优点在于: [0043] Compared with the prior art, advantages of the present invention:

[0044] 1、区别于整体瓣膜置换技术,本发明保留了自体瓣叶和瓣叶运动功能,通过助闭件防止脱垂瓣叶翻转,从而达到阻止瓣膜反流的目的,其具有植入物少,血液动力学好等优点。 [0044] 1, distinguished from the whole valve replacement techniques, the present invention retains autologous leaflets and leaflet motor function, preventing the closing member by co-leaflet prolapse inverted, so as to achieve the purpose of preventing valvular regurgitation, with the implant less, is good hemodynamic advantages.

[0045] 2、本发明所述助闭件的最大宽度小于单个所述自体瓣叶展开的最大宽度,所述的自体瓣叶既包括前后瓣瓣叶,又包括联合瓣瓣叶,适用范围比现有技术更广,不仅可以避免助闭件过宽对其他相邻瓣叶关闭功能的影响,而且可以进行周向调整使助闭件放置在最合适的脱垂部位,不仅植入物较少,并发症低,而且适应于不同的患者的瓣环尺寸,适应证得以扩展,厂商可以减少产品规格。 [0045] 2, the present invention is the co-closing member is smaller than the maximum width of the maximum width of a single expanded autologous leaflet, the leaflet autologous prosthetic both before and after the leaves, the leaves in turn comprises a prosthetic joint, the scope of application than broader prior art, not only help to avoid too wide impact of the closure member closing the other adjacent function leaflets, and can be adjusted so that the circumferential member is placed in close co optimal prolapse site, not only the implant was less , low complications, and to adapt to different patient annulus size, be expanded indications, manufacturers can reduce product specifications.

[0046] 3、本发明的推杆被用于控制锚定件的运动,当进行推送时,其推力结合所述阻止瓣膜反流的假体支撑力、所述输送管或者优选实施例中所述支撑装置的作用力,所述输送管的远端部分的刚性段的管壁对所述锚定件的限制力中的一种或多种,使所述锚定件在被预设的不同形状下,能够成功被推送入韧性心内膜和心内组织,弥补了现有技术中锚定件自体扎入力不充分,无法成功扎入心内膜和组织的技术缺陷,解决了锚定件在扎入过程中定位不易,容易滑脱,扎入后固定不稳,容易在血液冲刷下滑出等问题,本发明的技术充分实现了准确定位和牢固锚定的功能。 [0046] 3, the push rod of the present invention is used for controlling the motion of the anchor, when pushed, in conjunction with the thrust force to prevent the valve prosthesis support regurgitation, or the delivery tube of the preferred embodiment the rigid wall segment distal portion of the biasing force of said support means, said delivery tube to limit the force of the anchor of one or more of the anchor member is preset different shape, can successfully be pushed into the toughness and endocardial heart tissue, to make up for the prior art anchor bar into the autologous force insufficient to successfully pierce the technical defects and endocardial tissue, to solve the anchor in the rolling process is not easy to locate, easy to slip, after rolling into the unstable fixed easily falling out of the blood and other erosion problems, techniques of the present invention to achieve a sufficiently accurate and secure positioning of the anchoring function.

[0047] 4、本发明所述锚定件释放装置的远端部分具有预设的形状,使得所述输送管的远端部分能够整体弯曲或部分弯曲,保证当所述锚定件向所述输送管的远端移动时,所述输送管的远端能与韧性扎针部位相抵垂直,并且所述输送管的最远端为刚性段,使得所述输送管的远端可以紧抵自体组织,保证锚定件扎入的角度,并限定扎入路径,使所述锚定件在被预设的不同形状下,能够成功被推入韧性柔软的组织。 [0047] 4, the distal end portion of the anchor of the present invention means a given release member having a predetermined shape, such that the distal end portion of the delivery tube can be integrally bent or curved portion to ensure that when the anchor member to the when moving the distal end of the delivery tube, the distal end of the delivery tube can be brought into vertical and toughness acupuncture treatment site, the delivery tube and the most distal rigid section, so that the distal end of the delivery tube may be against autologous tissue, to ensure that the anchor bar into an angle, and defining a path into the bar, the anchor member at the predetermined different shapes, can be successfully pushed into the soft tissue of toughness.

[0048] 5、本发明中所述连接件为柔性,使得所述连接件以及与之相连的所述助闭件能够随着瓣叶的运动而运动,而不会影响自体瓣叶的运动功能。 [0048] 5, the present invention is a flexible connecting member, such that said connecting member and said closing member co-connected thereto with the movement of the flap can be moved without affecting the motor function of autologous flap .

[0049] 6、本发明中在所述助闭件和所述固定件之间具有供血液流过的通道,能够避免器械与患者瓣环附近的组织因长期接触而发生粘连。 [0049] 6, the present invention having a channel for blood to flow through between the promoter and the closing member fixing member can be avoided with the instrument near the patient tissue annulus due to the long contact adhesions.

[0050] 7、本发明中所述固定件采用非闭环的结构(所述固定件展开的宽度小于瓣膜组织环周长的2/3),减少了对心房壁的支撑力,避免了对心房以及相邻瓣膜运动功能的影响。 [0050] 7, the fixing member of the present invention, non-closed loop (the fixing member is smaller than the width of the expanded circumference of the annulus tissue 2/3), to reduce the support force of the atrial wall, to avoid atrial and the influence of the adjacent valve motor function.

[0051] 8、本发明的优选方案,还设置了调整装置,在影像辅助下,可以通过控制调整装置来调整阻止瓣叶反流的效果,直至效果最佳时将其固定于心尖和心室壁上。 [0051] 8, a preferred embodiment of the present invention, there is provided the adjusting means, at the auxiliary image, may be adjusted by controlling the adjusting means to prevent the effect of reflux flap, until the best effect when it is fixed to the ventricular wall and apical on.

附图说明 BRIEF DESCRIPTION

[0052] 图la-ld为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统的原理不意图,其中图lc为图lb的局部放大7]^意图;图Id为图lc在自体辦叶开放允许血流通过时的示意图。 [0052] FIGS. La-ld A tape of the present principles means for preventing regurgitation valve repair system is not intended to anchor according to the invention, in which FIG. 7 is a partial enlarged lc of FIG. Lb] ^ intended; Id FIG. lc is a schematic diagram in autologous do leaves open to allow blood to pass through.

[0053] 图2a_2p为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统的一个实施例的结构示意图,其中图2a-2b为所述阻止瓣膜反流假体的结构示意图;图2c-2h为本发明所述锚定件的优选实施例的结构示意图;图2i_2k为本发明所述锚定件释放装置的优选实施例的结构示意图;图21-2p为本发明所述输送管的优选实施例的结构示意图。 A structural diagram of an embodiment [0053] A present invention according to FIG 2a_2p with anchoring means for preventing regurgitation valve repair system, wherein FIGS. 2a-2b to prevent the prosthesis valvular regurgitation schematic structural diagram; FIG. 2c-2h of the anchor of the present preferred embodiment of a schematic structural diagram of the invention; FIG 2i_2k release the anchor means preferably schematic structural diagram of the embodiment of the present invention; the present invention, FIG 21-2p schematic structural diagram of a preferred embodiment of the delivery tube.

[0054] 图3a_3i为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统的操作过程示意图。 [0054] one of the anchoring device of the present invention with FIG 3a_3i present during operation of the valve for preventing reverse flow of the repair system FIG.

[0055] 图4a_4m为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统的另一个实施例的结构示意图和操作过程示意图,其中图4a为所述阻止瓣膜反流假体的结构示意图;图4b为所述锚定件释放装置的结构示意图;图4c_4h为所述修复系统的操作过程示意图;图4i-4j为所述支撑装置的另一个优选实施例的不同角度的结构示意图;图4k-4m 分别为所述支撑装置的三个优选实施例的结构示意图。 And another structural diagram of the operation [0055] FIG 4a_4m the present invention with an anchoring means for preventing regurgitation valve repair system schematic of the embodiment, wherein FIG. 4a is a stop valve regurgitation 4b is a schematic structural diagram of the anchoring member of the release means;; a schematic view of the prosthesis of FIG 4c_4h is a schematic view of the operation of the system repair; FIG. 4i-4j said support means at different angles to another preferred embodiment of the structural diagram; three schematic structural diagram of FIG. 4k-4m preferred are embodiments of the support means.

[0056] 图5a_5g为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统在被用于不同部位病症时的示意图,所述固定件展开后可沿患者瓣环的周向调整位置,其中图5a_5d为所述系统被用于治疗二尖瓣病症时的示意图;图5e_5g为所述系统被用于治疗三尖瓣病症时的示意图。 [0056] FIG schematic 5a_5g A tape anchored when used in different parts of a disorder means preventing valve repair system for the regurgitation of the present invention, the rear fixing ring member may be expanded along the patient valve adjusting the position of the circumferential direction, wherein FIG 5a_5d schematic view of the condition of the mitral valve therapy system is used; FIG 5e_5g schematic view of the treatment of a disorder of the tricuspid system is used.

[0057] 图6a_6g为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统的再一个实施例的结构示意图和操作过程示意图,其中图6b为图6a的局部放大结构示意图;图6g为图6f的局部放大结构示意图。 [0057] FIG 6a_6g A tape anchoring structure diagram and a schematic view of another example of the operation of the means for preventing regurgitation valve repair system according to one embodiment of the present invention, wherein FIG. 6b is a partially enlarged structure of FIG 6a a schematic diagram; FIG. 6g is a partial enlarged schematic view of the structure of FIG. 6f.

[0058] 图7a_7d为本发明所述的锚定件的优选实施例的结构示意图。 Schematic structural diagram of anchor [0058] FIG 7a_7d member of the present invention, a preferred embodiment is given.

[0059] 图8a_8e为本发明所述的阻止瓣膜反流的假体的优选实施例的结构示意图。 [0059] FIG 8a_8e schematic structural diagram of a preferred embodiment of the prosthetic valve to prevent regurgitation of the present invention.

具体实施方式: Detailed ways:

[0060] 为使本发明的目的、技术方案及优点更加清楚明白,以下参照附图并举实施例,对本发明进一步详细说明。 [0060] To make the objectives, technical solutions and advantages of the present invention will become more apparent, with reference to the accompanying drawings and the following embodiments, the present invention is further described in detail.

[0061] 本发明针对所述阻止瓣膜反流的假体,所述的远端是指远离心尖的一端,所述的近端是指接近心尖的一端。 [0061] The present invention is directed to a prosthetic valve to prevent regurgitation, a distal end remote from the apex means, the proximal end refers to the end closer to the apex. 本发明针对所述锚定件释放装置,所述的近端是指靠近所述锚定件释放装置操作件或者操作者的一端,所述的远端是指远离所述释放装置操作件或者操作者的一端。 The present invention is directed to the anchor member releasing means, said proximal end of said anchoring means near one end of the operating member or the release means of the operator member, the distal end of said release means is remote from the operating means or an operation member One end of persons.

[0062] 具体实施例一: [0062] a particular embodiment:

[0063] 如图la所示,一种带锚定装置的用于阻止瓣膜反流的修复系统,包括阻止瓣膜反流的假体1、四套锚定件释放装置2和输送系统3,用于治疗二尖瓣后瓣部分脱垂。 [0063] As shown in FIG La, A tape anchoring means for preventing regurgitation valve repair system, comprising a prosthetic valve to prevent regurgitation 1, four sets of device 2 and the delivery system to release the anchor member 3, with after the treatment of mitral valve prolapse section.

[0064] 如图2a_2b所示,所述阻止瓣膜反流的假体1包括固定单元11、连接件12和助闭件13。 [0064] FIG 2a_2b shown, the prosthetic valve to prevent regurgitation 1 comprises a fixing unit 11, the connecting member 12 and the closure member 13 co. 所述固定单元11包括固定件111和两个锚定件112,所述固定件111通过所述锚定件112被固定在患者自体组织4上,在本实施例中,仅在相邻两套锚定件释放装置2中装载有锚定件112,没有装载锚定件112的释放装置2被用做支撑装置,其远端部分在被释放后紧抵患者自体组织,给予整套所述释放装置2支撑力,从而能够在推送锚定件112后期给予其足够的反作用力,便于锚定件112扎入患者韧性组织。 The fixing unit 11 includes a fixing member 111 and two anchors 112, the fixing member 111 through the anchor member 112 is fixed to the patient's own tissue 4, in the present embodiment, only two adjacent anchor release device 2 loaded with anchor 112, the anchor is not loaded release means 112 is used as a support means 2, the distal end portion thereof immediately after being released against autologous tissue, administering the entire release device 2 supporting force, thereby pushing the anchor post 112 which is sufficient to give the reaction force, the anchor member 112 to facilitate patient toughness pierce the tissue. 所述固定件111的展开的宽度等于瓣膜组织环周长的1/3,所述固定件111具有由形状记忆镍钛合金丝编织并热定形制成的骨架结构,其上被覆有高分子膜,且在所述固定件111的两端缝制有紧密编织网状涤纶膜; 如图2c所示,所述锚定件112由直径0. 25mm的形状记忆镍钛合金丝制成,所述锚定件112 的最远端1121为尖锐状,所述锚定件112的远端部分1122被预热定形成弧形,所述锚定件的近端设置有防脱端1123,所述防脱端1123被预热定形为直径1. 1_的圆形,所述锚定件112上固定连接有定位线1124,所述的固定方式为采用金属套管夹接,如图2a-2b所示,所述定位线1124的另一端,被固定在所述固定件111上,当所述锚定件112被预先装入所述锚定件释放装置2的远端部分内时,所述锚定件112的伸展状态如图2d所示;在一个优选实施例中,如图2e-2f所示,所述锚定件112的防脱端1123由所 Expand a width of the fixing member 111 is equal to 1/3 of the circumference of the valve tissue annulus, the fixing member 111 having a shape memory nitinol wire woven and heat set skeleton structure formed thereon a polymer film coated with and both ends of the fixing member 111 are sewn tightly woven mesh of polyester film; shown in Figure 2c, the anchor member 112 is made of a diameter of 0. 25mm shape memory nitinol wire, said anchor 112 like a sharp distal-most end 1121, a distal end 112 of the anchor member 1122 is pre-set portion forms an arc, the proximal end of the anchor member is provided with a fixed retaining end 1123, the anti- off end 1123 is shaped to preheat the diameter of the circular 1. 1_, the anchor member 112 fixedly connected to a bit line 1124 is fixed, said sleeve is a metal clip connection, as in FIG. 2a-2b shown, the positioning of the other end of the wire 1124 is fixed to the fixing member 111, when the distal end portion of the anchor member 112 is pre-loaded into the anchoring member release device 2, the anchor as shown in an extended state set 112 in FIG 2D; embodiment, as illustrated in FIG 2e-2f in a preferred embodiment, the anchor end of the retaining member 112 by 1123 given by 远端部分1122进一步延伸预热定形而成,所述定位线1124被绕接在所述防脱端1123上;在另一个优选实施例中, 如图2g-2h所示,所述锚定件112的防脱端1123由形状记忆合金丝被预定形成双环制成。 The distal end portion 1122 extends further from amorphous preheating, the positioning wire 1124 is wound into contact with the said retaining end 1123; in another preferred embodiment, as shown in Fig 2g-2h, the anchor member 1,123,112 retaining end of a shape memory alloy wire is made of a predetermined form a bicyclic ring. 如图2a-2b所示,所述连接件12为片状,由高分子膜制成,为柔性,所述连接件12的远端部分与所述固定件111的近端部分相连,所述连接件12的近端部分与所述助闭件13的远端部分相连,在所述连接件12上设置有孔,所述孔为血液流过的通道121。 As shown in FIG. 2a-2b, the connecting member 12 is a sheet made of a polymer film, a flexible, distal end portion of the connecting member 12 is connected with a proximal end portion of the fixing member 111, the a proximal portion connecting member 12 is connected to the distal end portion of the closing member 13 of the co-channel 121 in the connecting member 12 is provided with a hole, the holes flowing blood. 在一个优选实施例中,所述助闭件13为单片和多片的组合,所述助闭件13的最远端由所述连接件12的单片高分子膜延伸而来,在所述助闭件13的中部分为两片,所述助闭件13的近端部分设置有展开装置131,所述展开装置131为形状记忆镍钛丝制成,被预热定形,所述展开装置131被固定在所述助闭件13内,横跨所述助闭件13的近端部分,防止所述助闭件13起皱或者被压缩;所述助闭件13上连接有调整结构132,所述调整结构132由高分子金属丝或高分子线制成,所述调整结构132的一端连接在所述助闭件13的近端上,所述调整结构132的另一端连接在心室或者心尖上,通过调整所述调整结构132两端之间的距离,可以调整所述助闭件13的阻反流的效果,如图lc-ld所示,所述助闭件13在自由状态时部分位于患者自体瓣叶7之间。 In a preferred embodiment, the promoter and closing member 13 is a monolithic combination of a plurality of sheets, the closing member 13 co-extending from the distal-most end of the polymer film 12 from a single piece of the connector, in the said closing member co-portion 13 is two, the co-closing member has a proximal portion 13 provided deployment device 131, the deployment device 131 is made of a shape memory nitinol wire, shaped by preheating the deployment device 131 is fixed to the closure member 13 co across the proximal portion 13 co-closing member 13 to prevent wrinkling or compressed the co-closing member; said co closing member 13 is connected to the restructuring 132, the adjustment structure 132 is made of a polymer or polymer wire line, one end of the adjustment structure 132 is connected to the proximal end of said co-closing member 13, the other end of the adjustment structure 132 is connected to the ventricular Alternatively the apex, by adjusting a distance between both ends of the adjustment structure 132 can be adjusted to help the reflux barrier effect of closing member 13, as shown in FIG. lc-ld, the co-closing member 13 in the free state when the body portion is located between the flap 7 from the patient. 在本实施例中,所述锚定件112与所述固定件111通过定位线1124相互连接,所述锚定件释放装置2与所述固定单元11的可拆卸连接通过所述锚定件112与所述锚定件释放装置2的可拆卸连接来实现。 In the present embodiment, the anchor member 112 and the fixed member are connected by 1,111,124 each bit line, the anchoring member 2 is connected to release means removably to the fixing unit 11 through the anchor member 112 and the anchor release means 2 is connected detachably to achieve.

[0065] 如图2i所示,所述四套锚定件释放装置2包括四套输送管21和四套推杆22,在一个优选实施例中,如图2j-2k所示,所述锚定件释放装置2包括三套输送管21和三套推杆22 (未示出)。 [0065] As shown in FIG. 2i, the four sets of anchor release means 2 comprises four sets of four sets of delivery tube 21 and the push rod 22, in a preferred embodiment, as shown in FIG 2j-2k, the anchor release means fixed member 2 includes a delivery tube 21 and three sets of three push rod 22 (not shown). 如图2i所示,所述输送系统3由公知技术制成,包括Tip头(引导头)31,鞘芯35,外鞘管32和操作件33、34,所述鞘芯35的远端与所述引导头31固定连接,所述鞘芯35的近端与所述操作件固定连接,所述输送管21和所述推杆22的近端部分211和221 (未示出),被分别固定连接在所述操作件33和34上,通过操作所述操作件33和34能够分别移动所述输送管21和所述推杆22。 As shown in FIG. 2i, the delivery system 3 is made of known techniques, including Tip head (guide head) 31, the sheath core 35, the outer sheath 32 and the operation member 33, the distal end of the sheath 35 and the core the guide head 31 is fixedly connected to the proximal end of the sheath of the core of the operating member 35 is fixedly connected to the delivery tube 21 and the proximal portion 22 of the pusher 211 and 221 (not shown), respectively fixedly connected to the operating member 33 and 34, by operating the operation member 33 and 34 respectively, the movable delivery tube 21 and the push rod 22. 如图21-2p所示,所述输送管21的远端部分212能够整体弯曲或者部分弯曲,所述输送管21能够弯曲的部分为弯曲段2121,在所述输送管21 的最远端设置有刚性段2122,所述刚性段2122的长度等于所述锚定件的全长,所述弯曲段2121为具有切缝的不锈钢管段,或者所述弯曲段2121为金属丝增强的高分子抗折管,所述输送管21的内径为1. 0mm。 FIG 21-2p, the distal end 21 of the delivery tube 212 can be integrally bent portion or curved portion, the duct portion 21 can be bent to a curved segment 2121 is provided at the most distal end of the delivery tube 21 rigid section 2122, the length of the rigid section 2122 is set equal to the entire length of the anchor member, said curved segment 2121 is a stainless steel pipe slit or a curved segment 2121 is wire reinforced polymer flexural tube, the inner diameter of the delivery tube 21 to 1. 0mm. 所述输送管的最远端到所述输送管21的弯曲段2121的最近端的长度等于以患者自体瓣膜组织环的最小半径r为半径做的圆的周长的1/3,所述的最小半径定义为在瓣环的截面方向,从瓣环到瓣环截面中心的最短距离。 The furthest end of the delivery tube 21 and delivery tube proximal-most curved section of length equal to 2121 autologous valve tissue annulus made minimum radius r is the radius of the circumference of a circle of 1/3 the minimum in cross-sectional direction is defined as a radius of the annulus, the annulus from the annulus to the center of the cross section of the shortest distance. 如图3a所示,所述锚定件释放装置2中的所述推杆22由形状记忆合金丝制成,所述推杆22的远端部分具有被预热定形的形状和角度,当所述锚定件释放装置2被释放时,所述推杆22可以恢复成以所述自体瓣膜组织环的最小半径r为半径做的圆的1/4个圆弧形状,如图3d所示,使得所述输送管21的远端部分212能够随着所述推杆22的被预热定形的远端部分整体弯曲或者部分弯曲,以便于在所述锚定件112被移动之前所述输送管21的最远端紧抵所述固定单元11或者紧抵自体组织4。 The As illustrated, the anchoring member 3a release means 22 in the push rod 2 is made of a shape memory alloy wire, said pusher having a distal end portion 22 of the preheated amorphous shape and angle, when the when the release means of said anchor member 2 is released, the pushrod 22 may be restored to the shape of a quarter circle arc to the minimum radius r of the native valve tissue annulus radius is done, as shown in FIG. 3d, such that the distal end of the delivery tube 21 with the plunger portion 212 can be pre-shaped curved distal portion 22 integrally or partially curved, so that prior to the anchor member 112 is moved to the delivery pipe the most distal end 21 of the fixing means 11 tightly abuts tightly against autologous tissue or 4. 如图3a所示,所述推杆22和所述锚定件112均被放置在所述输送管21内,所述锚定件112位于所述推杆22的远端。 As shown in FIG 3a, the push rod 22 and the anchor member 112 are disposed within the duct 21, the anchor member 22 at the distal end 112 of the push rod.

[0066] 一种带锚定装置的用于阻止瓣膜反流的修复系统的操作步骤如下:如图3a所示, 阻止瓣膜反流的假体1、四套锚定件释放装置2被径向压握在所述外鞘管32中,其中如图2d所示,两套锚定件112被分别预先装入相邻两套所述输送管21的远端的所述刚性段2122内,呈伸展状态,所述防脱端1123因弹性被限制在所述输送管21中。 [0066] A tape for preventing the anchoring device system valve repair procedure reflux follows: 3a, the prosthetic valve to prevent regurgitation 1, four sets of anchor release means is radially 2 crimping the outer sheath 32, shown in Figure 2d wherein the two sets of anchor member 112 are respectively pre-loaded into the distal end of the rigid section of the delivery tube 21 adjacent to the two inner 2122, was extended state, said retaining end 1123 is limited due to the elastic tube 21 of the delivery. 四套所述推杆22被分别预先放置在所述四套输送管21中,所述阻止瓣膜反流的假体1、锚定件释放装置2由所述输送系统3经心尖入路,从心室6被送入心房5,如图la所示。 The four sets of push rod 22 are respectively disposed in the four sets of pre-delivery tube 21, the stop 2 by a prosthetic valve regurgitation 1, anchor release means the delivery system 3 transapical approach, from 5 ventricular atrial 6 is fed, as shown in FIG. la. 如图3b-3c所示, 通过操作输送系统3后撤外鞘管32,释放所述阻止瓣膜反流的假体1和锚定件释放装置2, 所述输送管21随着所述推杆22弯曲,恢复成所述推杆22被预定形的形状,即所述锚定件释放装置2的远端部分恢复成预设的形状。 , By operating the delivery system 3 to retreat the outer sheath 32, as shown in FIG 3b-3c the release valve regurgitation preventing prosthesis 1 and the anchor release means 2, the duct 21 as the pusher 22 is bent, is restored to the predetermined shape of the push rod 22, i.e., the distal end portion of the device 2 of the anchor member into a predetermined shape recovery release. 如图3d所示,在此过程中,由于所述固定件111 的展开的宽度等于瓣膜组织环周长的1/3,所以可以通过旋转所述输送系统3,来调整所述固定件111的位置,直至到达阻反流效果最好的部位。 Shown in Figure 3d, in this process, since the width of the fixing member 111 to expand the circumference of the ring is equal to 1/3 of the valve tissue, it is possible by rotating the delivery system 3, to adjust the fixing member 111 position, until it reaches the site of the best anti-blocking flow effect. 由于所述定位线1124的限制定位作用,所述固定件111被夹在所述输送管21的远端与所述自体组织4之间,如图3d-3f所示, 此时,所述锚定件112的扎入路径被限定,完成定位操作。 Positioning action due to the limitation of the bit lines 1124, the fixing member 111 is sandwiched between the distal end of the delivery tube 21 with the autologous tissue between the 4, as shown in FIG. 3d-3f, at this time, the anchor tie into the path setter 112 is defined, the positioning operation is completed. 如图3g所示,推动所述推杆22 使所述锚定件112向所述输送管21的远端移动,所述锚定件112被释放,所述锚定件最远端1121刺破所述固定件111两端的涤纶膜,穿过所述固定件111,刺入自体组织4,所述锚定件的远端部分1122恢复所述被预设的形状。 As shown in FIG 3g, pushing the push rod 22 so that the anchor member 112 moves toward the distal end of the delivery tube 21, the anchor member 112 is released, distal-most end of the anchor member 1121 pierce polyester film 111 at both ends of said fixing member, through said fixing member 111, 4 autologous tissue penetrating distal end portion of the anchor member 1122 is preset shape recovery. 如图3h所示,进一步后撤所述外鞘管32, 释放所述助闭件13和调整结构132的远端。 As shown in FIG 3h, further retreat of the outer sheath 32, distal end 13 to release the closing aid and adjustment structure 132 of the member. 如图3i所示,后撤所述输送管21,释放所述锚定件112的防脱端1123,此时,所述锚定件的防脱端1123恢复其预先定形的形状,所述阻止瓣膜反流的假体1位于自体组织4与所述锚定件的防脱端1123之间,被牢固固定。 FIG. 3i, withdraw the delivery tube 21, preventing the release of the anchor 112 off the end of 1123, at this time, the anchor end retaining member 1123 to resume its pre-set shape, said blocking valvular regurgitation prosthesis 1 4 autologous tissue positioned with the anchor member between the retaining end of 1123, is firmly fixed. 将所述外鞘管32前推至距离外鞘管32与所述Tip头31的接合处l-3mm处,后撤所述输送系统3,从心尖退出,此时所述调整结构132的近端随着所述输送系统3被撤出心脏,再从所述输送系统3中被拉出,最终,如图lb所示,在影像的辅助下,调整其固定心尖端的松紧,来调整所述组织瓣膜反流的假体的阻反流效果。 32 to push the front of the outer sheath 32 and the outer distance of said engaging head 31 Tip of the sheath l-3mm, withdraw the delivery system 3, exits from the apex, when the adjustment of the structure 132 near with the end of the delivery system is withdrawn heart 3, 3 and then be pulled out of the delivery system, and finally, as shown in FIG lb, with the aid of the image, adjusting the tip of the fixed core cord which adjusts the said tissue valve prosthesis regurgitation reflux barrier effect. 如图lb-ld所示,所述助闭件13与所述自体瓣叶7 -起运动,起到阻反流的效果。 As shown in FIG lb-ld, the closing member 13 with the aid of autologous leaflet 7-- from movement, blocking effects play reflux.

[0067] 具体实施例二: [0067] DETAILED Example II:

[0068] 如图4a_4c所示,一种带锚定装置的用于阻止瓣膜反流的修复系统,包括阻止瓣膜反流的假体1、两套锚定件释放装置2、输送系统3和两套支撑装置8,用于治疗二尖瓣前瓣部分脱垂。 [0068] As shown in FIG 4a_4c, A tape anchoring device for preventing regurgitation valve repair system, comprising a prosthetic valve to prevent regurgitation 1, two anchor release means 2, 3 and two delivery systems sets of support means 8, for the treatment of anterior mitral valve prolapse portion.

[0069] 如图4a所示,所述阻止瓣膜反流的假体1包括固定单元11、连接件12和助闭件13。 [0069] Figure 4a, the prosthetic valve to prevent regurgitation 1 comprises a fixing unit 11, the connecting member 12 and the closure member 13 co. 所述固定单元11包括固定件和两个锚定件112,在本实施例中,所述固定件和所述锚定件112为一体结构,所述固定件通过所述锚定件112被固定在患者自体组织上,所述固定单元11展开后,两个所述锚定件112之间的宽度等于瓣膜组织环周长的1/4 ;所述连接件12 为条状,由双股形状记忆合金镍钛丝绕制并且预热定形而成,所述连接件12的两侧为血液通过的通道121,所述连接件12的一端被固定连接在所述锚定件112上,所述连接件12的另一端被固定连接在所述助闭件13上;所述助闭件13为单片状,由高分子膜制成,所述助闭件13的近端设置有展开装置131,所述展开装置131由显影丝围绕在所述助闭件13的外周边界上制成,便于所述助闭件13的展开;如图4d所示,所述锚定件112由直径0. 3mm 的形状记忆镍钛合金丝制成,所述锚定件112的最远端1121为尖锐状,所述锚定件112的远 The fixing unit includes a fixing member 11 and two anchors 112, in the present embodiment, the fixing member and the anchor member 112 as an integral structure, the fixing member 112 through the anchor member is fixed after the patient's own tissue, the fixing unit 11 is expanded, the width between the two anchoring members 112 is equal to 1/4 of the circumference of the valve annulus tissue; said connecting member is a strip 12, a double-stranded form nickel-titanium memory alloy wire wound from amorphous and preheated, the connecting member 12 on both sides of the channel 121 through the blood, an end of the connecting member 12 is fixedly connected to the anchor member 112, the the other end of the connecting member 12 is connected fixed to the closing member 13 promoter; the promoter is a single sheet-like closing member 13 is made of a polymer film, the proximal end of the co-closing member 13 is provided with a deployment of the device 131 , the deployment device 131 is made of a developing around the peripheral boundary wire in the co-closing member 13, to facilitate the co-closing member 13 is expanded; As shown, the anchor member 112 having a diameter of 0 4d. 3mm made of a shape memory nitinol wire, said anchor member distal-most end of a sharp shape 1121112, the distal anchor member 112 is fixed 部分1122被预热定形成弧形,所述锚定件112的近端设置有防脱端1123,所述防脱端1123由设置有内螺纹结构的不锈钢管制成,所述防脱端1123与所述锚定件112的近端通过焊接连接。 Part 1122 is shaped to preheated curved, the proximal end of the anchor member 112 is provided with fixed retaining ends 1123, 1123 of the retaining end provided with an internal thread structure of the stainless steel tubing, with the retaining end 1123 said anchor member proximal end 112 is connected by welding. 如图4b-4c所示,所述锚定件释放装置2包括两套输送管21和两套推杆22 (未示出),所述输送系统3由公知技术制成,包括Tip头(引导头)31,外鞘管32和操作件33、 34 (未示出),鞘芯35,所述鞘芯35的远端与所述引导头31固定连接,所述鞘芯35的近端与所述操作件固定连接,所述输送管21和所述推杆22的近端被分别固定连接在所述操作件33和34上,通过操作所述操作件33和34能够分别移动所述输送管21和所述推杆22。 As shown in FIG. 4b-4c, the anchoring member 2 comprises a release device delivery tube 21 and two sets of push rod 22 (not shown), the delivery system 3 is made of known techniques, including Tip head (guide head) 31, 33, 34 (not shown), the sheath core 35, the distal end of the sheath to the core 35 with guide head 31 is fixedly connected to the proximal end of the outer sheath of the core 35 and the sheath operating member 32 and said operating member is fixedly connected to the proximal end of the delivery tube 21 and the pusher 22 are respectively fixedly connected to said operating member 33 and 34, can be moved by operating the operation member 33 and the conveyor 34 are the push rod 21 and tube 22. 如图4d所示,所述输送管21的远端部分212由金属螺旋增强高分子管制成,能够整体弯曲, 所述输送管21的近端部分为不锈钢管,所述远端部分212被热熔套接在所述输送管21的近端部分上,在所述输送管21的最远端设置有长度等于所述锚定件全长的一半的刚性段, 由不锈钢管制成,所述输送管的最远端到所述输送管的弯曲段212的最近端的长度等于以患者自体瓣膜组织环的最小半径r为半径做的圆的周长的1/2,所述的最小半径定义为在瓣环的截面方向,从瓣环到瓣环截面中心的最短距离。 Shown in Figure 4d, the distal end portion 21 of the delivery tube 212 by a metal spiral reinforced polymer tubing can be curved as a whole, the proximal end of delivery tube 21 is a stainless steel tube portion, the distal portion 212 is thermally melt sleeved on the proximal portion of the delivery tube 21 is provided at the distal-most end of the delivery tube 21 has a length equal to half the entire length of the rigid section of a given member of the anchor, made of stainless steel to control the delivery the furthest end of the duct pipe section nearest the bent end 212 of a length equal to the minimum radius r autologous tissue valve ring made of 1/2 radius, the minimum radius of the circle defining the circumference of the cross-sectional direction of the annulus, the annulus from the annulus to the center of the cross section of the shortest distance. 所述推杆22由双层螺旋编织丝制成,可以传递扭矩,内衬有形状记忆合金镍钛丝,其远端部分222被预热定形成具有一定的角度,当所述锚定件释放装置2被释放时,所述推杆22可以恢复成以所述自体瓣膜组织环的最大半径R为半径做的圆的1/4个圆弧形状,所述推杆的最远端223上设置有带有与所述防脱端1123的内螺纹相匹配的外螺纹结构的钢套,所述推杆22被放置在所述输送管21 内,所述锚定件112的防脱端1123位于所述推杆22的远端,与所述推杆22的最远端223通过螺纹连接,所述锚定件释放装置2与所述固定单元11的可拆卸连接通过所述锚定件112 与所述锚定件释放装置2的推杆22的可拆卸连接来实现,所述推杆22的远端部分222恢复成预设的形状,使得所述输送管21的所述弯曲段212随之弯曲。 The push rod 22 is made of a double spiral woven wire can transmit torque lined with nickel-titanium shape memory alloy wire, its distal end portion 222 is formed to have a certain pre-set angle, the release member when the anchor when the device 2 is released, the push rod 22 to be restored to the maximum radius R from the body of the valve tissue annulus made circle radius 1/4 arc shape, the push rod 223 is provided on the distal-most there externally threaded steel sleeve retaining structure and the internally threaded end 1123 of the match, the push rod 22 is disposed in the duct 21, the anchoring member 112 is located in the retaining end 1123 the distal end of the push rod 22, 2 detachably connected to the fixing unit 11 by the push rod 223 by screwing the distal-most, the anchor member 22 of the release means 112 and the anchor member releasing the anchor member is detachably connected to the pusher means 22 2 is achieved, the distal end portion of the push rod 22 is restored to a predetermined shape 222, such that the delivery tube 21 along the curved sections 212 bending. 如图4b所示,所述带锚定装置的用于阻止瓣膜反流的修复系统还包括两套支撑装置8,所述支撑装置8的近端与所述输送系统3的操作件固定连接,所述支撑装置8由直径0. 8_的形状记忆合金镍钛丝制成,远端部分具有与所述推杆22相同的预热定形形状,能够弯曲,使得所述支撑装置8被释放后,远端部分抵住自体组织4,由于自体组织4自身的弹性,在所述支撑装置8的远端部分紧抵自体组织4时,自体组织4给予所述远端部分相反的作用力F,由于所述支撑装置8 与所述输送管21直接接触或间接接触,例如所述支撑装置8与所述输送管21呈圆周均分分布,所述支撑装置8则相应地将所述反作用力F传递给其对侧的输送管21或者将所述反作用力F的分力传递给与其直接接触或者间接接触的输送管21,所述支撑装置8提供的支撑力F能够保证与其直接接触或间接接触的输送管21能 4b, with the anchoring means for preventing regurgitation valve repair system further comprises two supporting means 8, the support means 8 and the proximal end of the delivery system of the operating member 3 is fixedly connected, the diameter of the support device 8 is made of a shape memory alloy of nickel-titanium wire 0.5 8_, after the distal end portion having a pre-set shape of the same push rod 22 can be bent so that the supporting device 8 is released , the distal end portion 4 against autologous tissue, autologous tissue due its elasticity 4, the distal end portion of the support means 8 tightly against self tissue 4, autologous tissue administering to said distal end portion 4 opposite to the force F., Since the support means 8 and the duct means 21 direct or indirect contact, for example, the support means 8 and the duct 21 circumferentially divided equally distributed, the support 8 correspondingly to the reaction force F passed to the delivery tube 21 opposite thereto, or the reaction force F is transmitted to the component in direct contact or indirect contact with the delivery tube 21, the support means 8 provides support to ensure that the force F can be in direct or indirect contact the delivery tube 21 can 继续抵住所述自体组织4,限定扎针路线,保证所述锚定件112能刺入自体组织4。 Continuing against the autologous tissue 4, defining the route acupuncture treatment, to ensure that the anchor member 112 can pierce the body tissue from 4.

[0070] 在另一个优选的实施方式中,如图4i-4j所示,所述的一种带锚定装置的用于阻止瓣膜反流的修复系统,包括阻止瓣膜反流的假体1、两套锚定件释放装置2、输送系统3和两套支撑装置8,所述两套支撑装置8相邻,与所述两套锚定件释放装置2呈圆周均分分布, 所述输送系统3包括引导头31、外鞘管(未示出)、鞘芯35和操作件(未示出),所述鞘芯35被设置在外鞘管内,所述鞘芯35的远端与所述引导头31固定连接,所述鞘芯35的近端与所述操作件固定连接,在释放前,所述心脏瓣膜假体1、所述锚定件释放装置2和所述支撑装置8均被设置在所述外鞘管与所述鞘芯35之间,所述支撑装置8由不锈钢管制成,所述支撑装置8的近端81与所述输送系统3的所述操作件固定连接,所述支撑装置8的远端部分82设置有切缝,使得所述支撑装置8的远端部分82能够弯曲,在所述支 [0070] In another preferred embodiment, shown in FIG. 4i-4j, the one with the anchoring means for preventing regurgitation valve repair system, including valvular regurgitation preventing prosthesis 1, two anchor release means 2, 3 and two delivery systems support means 8, the two adjacent support means 8, the device 2 sets of circumferentially anchor average release profile, the delivery system 3 comprises a guide head 31, the outer sheath (not shown), the core 35 and the sheath operating member (not shown), the sheath core 35 is disposed within the outer sheath, the distal end of the sheath of the core 35 and the guide head 31 is fixedly connected to the proximal end of the core sheath operating member 35 is fixedly connected with, before being released, the heart valve prosthesis, the anchoring member 2 and the release means 8 are provided support means between the outer sheath and the sheath of the core 35, the support 8 is regulated by means of stainless steel into the proximal end 81 of the conveying means 8 of the support system fixedly connected to the operating member 3, the the distal end portion 82 is provided with a supporting device 8 of the slit, such that the distal end of the support means 8 can be bent portion 82, the branch 撑装置8的远端部分82上还活动连接有刚性的支撑杆822,所述支撑杆822的远端与所述引导头31活动连接。 Supporting means further activity on the distal end portion 8 is connected to a rigid support bar 82 822, the distal end of the support bar 822 and the guide head 31 active connections. 在一个优选的实施例中,如图4j所示,以所述支撑装置8的远端部分82和所述支撑杆822的连接处为分界线,所述远端部分82在位于所述分界线远端的部分821和位于所述分界线的近端的部分823上设置的切缝的位置相反,以便形成"S"形的弯曲。 In a preferred embodiment, shown in FIG. 4j, to the support means 82 and the distal end portion 8 of the support rod 822 is connected at the boundary, the distal portion 82 is located at the boundary line slit portion 823 provided at a position of the distal end portion 821 and a proximal end located opposite the boundary line to form a "S" shaped bend. 所述推杆22的远端部分被预热定形成具有一定的角度,所述推杆22可以回复成以所述自体瓣膜组织环的最大半径R为半径做的圆的1/4个圆弧形状,所述推杆22的最远端在被推送过程中,始终位于所述分界线的近端的部分823内,当所述锚定件释放装置2和所述支撑装置8 被释放后,所述支撑装置8的所述远端部分82在所述引导头31和所述支撑杆822的作用下弯曲,首先是位于所述分界线的近端的部分823随着所述推杆预设的形状弯曲,当位于所述分界线的远端的部分821与自体组织接触后,由于其上设置有切缝,位于所述分界线的远端的部分821逐渐弯曲,然后紧紧抵住自体组织。 The pusher distal end portion 22 is formed to have a certain pre-set angle to the push rod 22 can respond to the maximum radius R from the body of the valve tissue annulus as radius of the circle arcs 1/4 shape, the push rod is pushed in the distal-most course, always located within the proximal end 22 of the boundary portion 823, when the anchor release means 2 and the support means 8 after being released, the distal end portion of the support means 8 of the guide head 82 and the support rod 31 is bent under the action 822, first portion 823 is located on the proximal end of the push rod with a predetermined boundary line the curved shape, when the boundary portion 821 positioned in contact with the distal end of autologous tissue, since it is provided with a slit, located in the boundary of the distal end portion 821 is bent gradually, and then firmly against autologous organization. 由于自体组织自身的弹性,在所述支撑装置8的所述远端部分82紧抵自体组织时,自体组织给予所述远端部分82相反的作用力F,由于所述支撑装置8与所述输送管21间接接触,例如所述支撑装置8与所述输送管21呈圆周均分分布,所述支撑装置8则相应地将所述反作用力F传递给其对侧的输送管,所述支撑装置8提供的支撑力能够保证与其间接接触的输送管21能够继续抵住所述自体组织,限定扎针路线,保证所述锚定件112能刺入自体组织。 Since autologous tissue own elasticity, the distal end of the apparatus 8 in the supporting portion 82 is tightened against autologous tissue, autologous tissue administering to the distal end portion 82 opposite to the force F., Since the support means 8 and the delivery tube 21 indirect contact, for example, the support means 8 and the duct 21 circumferentially divided equally distributed, the support means 8 correspondingly to the reaction force F is transmitted to the delivery tube opposite thereto, said support support means 8 provides force to ensure indirect contact with the delivery tube 21 to continue against the autologous tissue, defining the route acupuncture treatment, to ensure that the anchor member 112 can be self-penetrating tissue. 在一个更优选的实施例中,在所述输送管21的远端部分上也活动连接有刚性的支撑杆822,所述支撑杆822的远端与所述引导头31活动连接,以便更好地控制所述输送管21的远端部分的弯曲角度。 In a more preferred embodiment, in the distal portion of the delivery tube 21 is also movably connected with a rigid support rods 822, the support rod distal end 822 of the guide head 31 is movably connected, in order to better controlling the bending angle of the distal portion of the delivery tube 21. 在另一个优选实施例中,如图4k所示,所述支撑装置8数量为一套,所述输送管21数量为一套时,所述支撑装置8与所述输送管21呈对称分布。 In another preferred embodiment, shown in FIG. 4k, the support means 8 is set quantity, the quantity of a delivery tube 21, the support means 8 and the substantially symmetrically delivery tube 21. 或者在另一个优选实施例中,如图41所示,所述支撑装置8的近端与所述输送系统的所述操作件固定连接并且所述支撑装置8的远端与所述输送系统的所述引导头31活动连接,在所述输送管21的远端部分上活动连接有刚性的支撑杆822,所述支撑杆822的远端与所述引导头31活动连接。 Or, in another preferred embodiment, shown in Figure 41, the operating member is fixedly connected to the proximal end of the delivery means 8 and the system 8 of the support means and the distal end of the delivery system and the support the articulated guide head 31, the delivery tube in the distal end portion 21 activity on a rigid support bar 822 is connected, the distal end of the support bar 822 is connected to the guide head 31 activity. 或者在另一个优选实施例中,如图4m所示,所述支撑装置8的近端与所述输送系统的所述操作件固定连接,所述支撑装置8的远端部分能够弯曲,并且其最远端游离,在所述输送管21的远端部分上活动连接有刚性的支撑杆822,所述支撑杆822的远端与所述引导头31活动连接。 Or, in another preferred embodiment, shown in FIG. 4m, said operating means 8 and the proximal end of the delivery system is fixedly connected to the support, the distal end portion of the supporting device 8 is capable of bending, and which the most distal free, active in the delivery tube 21 is connected to the distal portion of the rigid support rods 822, the support bar 822 is connected to the distal end of the guide head 31 activity. 在另一个优选的实施例中,所述锚定件112和所述锚定件释放装置2的数量不是一一对应的,所述锚定件释放装置2的套数大于所述锚定件112的数量,没有放置所述锚定件112的锚定件释放装置2可以作为所述的支撑装置8使用。 In another preferred embodiment, the anchor member 112 and the anchor releasing device number 2 is not one to one, the number of sets anchor release means fixed member 2 is larger than the anchor 112 number, no placement of the anchor member of the anchor member 112 of the release device 2 may be used as a supporting means 8 used.

[0071] 一种带锚定装置的用于阻止瓣膜反流的修复系统的操作步骤如下:如图4c所示, 阻止瓣膜反流的假体1、两套锚定件释放装置2和两套支撑装置8被径向压握在所述外鞘管32中,其中所述两套锚定件112被分别预先装入两套相邻的所述输送管21的远端部分内, 所述锚定件112的远端部分1122位于所述输送管21的所述刚性段内,呈伸展状态,所述防脱端1123与所述推杆的最远端223螺纹连接。 Procedure [0071] A tape anchoring means for preventing regurgitation valve repair system is as follows: as shown, valvular regurgitation preventing prosthesis 1, two anchor release means 2 and two in FIG. 4c supporting means 8 is radially crimped on the outer sheath 32, wherein two sets of said anchor member 112 is pre-loaded into each of the two adjacent inner portion 21 of the delivery tube distal end, the anchor the distal end portion 1122 of the fixed member 112 of the delivery tube positioned within said rigid section 21, is tensioned, retaining the terminal 1123 is connected to the distal-most end 223 of the threaded push rod. 两套所述推杆22被分别预先放置在两套所述输送管21中,所述阻止瓣膜反流的假体1、锚定件释放装置2由所述输送系统3经心尖入路,通过操作输送系统3后撤外鞘管32,释放所述阻止瓣膜反流的假体1、锚定件释放装置2和支撑装置8,如图4d所示,所述输送管21随着所述推杆22弯曲,恢复成所述推杆22被预定形的形状,所述支撑装置8的远端部分恢复成与所述推杆22被预定形状相同的形状, 同样的,在此过程中,由于所述固定单元11展开后,所述锚定件112之间的宽度等于瓣膜组织环周长的1/4,所以可以通过旋转所述输送系统3,来调整所述锚定件112 (即固定件)的位置,直至到达阻反流效果最好的部位。 The two sets of push rod 22 are respectively disposed in the two pre-delivery tube 21, the prosthetic valve to prevent regurgitation 1, 2 is released by the anchor means the delivery system 3 transapical approach, through operating the delivery system 3 to retreat the outer sheath 32, releasing the prosthetic valve to prevent regurgitation 1, 2 anchor release means 8 and support means, shown in Figure 4d, the duct 21 with the push bent lever 22, the push rod 22 is restored to a predetermined shape, the distal end portion of the support means 8 to be restored to the same shape as the predetermined shape of the push rod 22, the same, in this process, since the the fixing unit 11 after deployment, the anchor member 112 is equal to the width between the circumference of the tissue annulus 1/4, it can be 3, the anchor member is adjusted by rotation of the delivery system 112 (i.e., fixed member) position until it reaches the site of the best anti-blocking flow effect. 如图4e-4f所示,推动所述推杆22使所述锚定件112向所述输送管21的远端移动,所述锚定件112被释放,所述锚定件112的最远端1121 刺入自体组织4,所述锚定件112的远端部分1122恢复所述被预定形的弧形形状。 As shown in FIG. 4e-4f, pushing the push rod 22 so that the anchor member 112 is moved to the distal end of the delivery tube 21, the anchor member 112 is released, the anchor member 112 of a given farthest 1121 autologous tissue piercing end 4, the anchor member distal portion 112 of the arc shape 1122 to be restored to a predetermined shape. 如图4g 所示,操作所述输送系统3的操作件,使所述推杆22扭转,从而使所述防脱端1123和所述推杆22的最远端223的可拆卸连接被拆除,释放所述防脱端1123。 As shown in FIG. 4g, operating the delivery system of the operating member 3, the push rod 22 to reverse, thereby releasably retaining the distal-most end 223 of the push rod 1123 and connector 22 is removed, releasing the retaining end 1123. 如图4h所示,操作所述输送系统3的操作件,使所述输送管21后撤,所述锚定件112将所述阻止瓣膜反流的假体1固定在患者自体组织4上,所述助闭件13与所述自体瓣叶7 -起运动,起到阻反流的效果。 As shown in, FIG. 4h operation of the delivery system of the operating member 3, the delivery tube 21 to retreat, the anchor member 112 prevents the prosthetic valve regurgitation fixed tissue from a patient body 4, the closure member 13 with the aid of autologous leaflet 7-- from movement, play blocking effect reflux.

[0072] 具体实施例三: [0072] DETAILED Example III:

[0073] 如图5a_5g所示,所述阻止瓣膜反流的假体1包括固定单元11、连接件12和助闭件13,所述固定单元11包括固定件111和锚定件112,区别于现有技术中完整环状结构产品,所述固定单元11展开后可沿患者瓣环的周向调整位置,如联合瓣位置(图5a)、前瓣叶位置(图5b)或者后瓣叶位置(图5c),直至在手术操作者根据所述助闭件13与自身瓣叶7贴合情况判断好最合适的阻反流的位置后,再进行锚定定位,释放所述锚定件112,实现所述假体1与自体组织4之间的固定,真正实现了在准确治疗病变的同时,保留了剩余心脏瓣膜的正常生理功能,减少了对正常运作的心脏瓣膜的干涉,实现位置可调、定位准确、牢固锚定和病变适应性,而且能够防止因压迫联合瓣导致新的瓣周漏。 [0073] As shown in FIG 5a_5g, the prosthetic valve to prevent regurgitation 1 comprises a fixing unit 11, the connecting member 12 and the closure member 13 co, the fixing unit 11 includes a fixing member 111 and the anchor member 112, is different from complete a cyclic structure in the prior art product, after the fixing unit 11 may be ring expanded circumferentially along the patient valve to adjust the position, such as the United flap position (FIG. 5A), the front flap position (FIG. 5b) or the rear flap position (Figure 5C), until the operator determines the most appropriate good blocking position under reflux 13 itself leaflet 7 where the co-bonded closure member, then positioning the anchor, the anchor member 112 is released , to achieve a prosthesis fixing between 1 and 4 from the tissue, while truly accurate treatment of lesions, retains the remaining normal physiological function of the heart valve, to reduce interference with the normal functioning of the heart valve, the position can be achieved adjusting, positioning accuracy, adaptability and diseased rigidly anchored, and the joint can be prevented due to compression results in a new flap paravalvular leakage. 当患者出现多处不同位置的瓣叶脱垂时,传统的完整环状产品由于空间所限,若采用较大面积的助闭件则会压迫自身正常的瓣叶关闭,若采用较小面积的助闭件则无法取得良好疗效,且完整环状结构产品会压迫相邻器官,如主动脉瓣,影响其正常功能。 When patients with multiple different positions leaflet prolapse, traditional full annular product Due to space constraints, the use of a larger area of ​​the closing member co-compression itself will normally closed valve leaflets, the use of a smaller area help closing member can not achieve good results, and complete a ring structure of the product will be oppressed adjacent organs, such as the aortic valve, affecting its normal function. 而本发明所述固定件111展开的宽度较小,允许医生在不同病灶位置植入多枚器械,如图5d所示,增强阻止瓣膜反流的作用。 And said fixing member 111 of the present invention to expand the width of the smaller pieces of equipment allows a physician to implant multiple lesions at different positions, as shown in FIG. 5D, enhance the role of the valve to prevent regurgitation. 当所述阻止瓣膜反流的假体1被应用于治疗三尖瓣关闭不全时,同样的,所述固定单元11展开后,可沿患者瓣环周向调整位置,如图5e-5g所示。 When the valvular regurgitation preventing the prosthesis 1 is used to treat tricuspid regurgitation, the same, the fixing unit 11 to expand, can be adjusted to a position along the circumference of the annulus patient, 5e-5g shown in FIG. .

[0074] 具体实施例四: [0074] DETAILED DESCRIPTION Example 4:

[0075] 如图6a_6g所示,为本发明所述的一种带锚定装置的用于阻止瓣膜反流的修复系统,包括阻止瓣膜反流的假体1、锚定件释放装置2和输送系统3,从心尖入路,用于治疗二尖瓣关闭不全。 [0075] As shown in FIG 6a_6g, A tape anchoring device for preventing regurgitation valve repair system according to the present invention comprises a prosthetic valve to prevent regurgitation 1, the anchoring member 2 and the transporting release means 3 system, from the apical approach for the treatment of mitral regurgitation.

[0076] 如图6a所示,与具体实施例二的不同之处在于,所述假体固定件111与所述锚定件112在被输送到病变部位的过程中是分离的,所述锚定件释放装置2与所述固定单元11 的可拆卸连接通过所述固定件111与所述锚定件释放装置2的可拆卸连接来实现。 [0076] As shown in FIG 6a, the specific embodiment differs from the two embodiments is that the prosthesis fixing member 111 and the anchor member 112 is delivered to the lesion site during separate the anchor release means detachably fixed member 2 and the fixing unit 11 is achieved by connecting the fixing member 111 is removably connected to the anchor member release device 2. 如图6a所示,所述锚定件112由直径0. 4mm的形状记忆镍钛合金丝制成,所述锚定件112的最远端1121为尖锐状,所述锚定件112的远端部分1122被预热定形成弧形,所述锚定件112 的近端被设置有防脱端1123,所述防脱端1123由设置有内螺纹结构的不锈钢管制成,所述防脱端1123与所述锚定件112的近端被焊接连接。 6a, the anchor member 112 is made of a shape memory nitinol wire diameter of 0. 4mm, the distal-most end of the anchor member 112 to 1121 given a sharp shape, the distal anchor member 112 is fixed preheated end portion 1122 is shaped to arc, given the proximal anchor 112 is provided with a retaining ends 1123, 1123 of the retaining end provided with an internal thread structure of the stainless steel tubing, said retaining end 1123 and the proximal end of the anchor member 112 is welded connection. 如图6a-6b所示,所述输送管21由不锈钢管制成,包括两层管211和212,其中内层管211被放置于外层管212中,所述外层管212的远端部分固定连接有连接线23,所述连接线23的另一端穿过所述防止瓣膜反流的假体1后绕回,被夹在所述内层管211和外层管212的远端部分之间,所述连接线23由直径0. 1mm的形状记忆合金镍钛丝制成。 As shown in FIG. 6a-6b, the duct 21 into a stainless steel control, comprising two tubes 211 and 212, wherein the inner tube 211 is disposed in the outer tube 212, the distal end portion of the outer tube 212 line 23 is connected is fixed, the other end of the connecting line 23 passes through the rear prevents a wrap-around prosthetic valve regurgitation, is sandwiched between the distal end portion of the inner tube 211 and outer tube 212 of between the diameter of the line 23 is made of a shape memory alloy of nickel-titanium wire 0. 1mm. 所述内层管211和外层管212的远端被变径缩口,所述内层管211和外层管212的远端部分能够由于所述锚定件释放装置2的远端部分具有的预设的形状而实现整体弯曲,所述内层管211和外层管212能够弯曲的部分为弯曲段,在所述弯曲段上具有切缝,在所述输送管21的最远端设置有刚性的无切缝段,所述刚性段的长度大于所述锚定件112全长的三分之一,所述输送管21的近端固定连接有输送管操作件(未示出),所述内层管211和外层管212被分别固定连接在所述输送管操作件上,或者所述输送管21的近端被固定连接在所述输送系统3的所述操作件上。 The distal end of the inner tube 211 and outer tube 212 is adjustable constriction, the distal end portion of the inner tube 211 and outer tube 212 of the distal end portion of the device 2 can be due to the release of said anchor member having the predetermined curved shape is achieved overall, the inner tube 211 and outer tube 212 can be bent portion curved section, having a slit on the curved section, the distal-most end of the delivery tube 21 is provided rigid non-slit section, the rigid section is greater than the length of the anchor member 112 one-third the entire length of the delivery tube 21 is fixed to the proximal end of the delivery tube connected to the operating member (not shown), the inner pipe 211 and outer pipe 212 are respectively fixedly connected to the conveying pipe operating member, or proximal end of the delivery tube 21 is fixedly connected to said operating member 3 of the delivery system. 所述输送管21的最远端到所述输送管21的弯曲段212的最近端的长度等于以患者自体瓣膜组织环的最大半径R为半径做的圆的周长的1/3,所述的最大半径定义为在瓣环的截面方向,从瓣环到瓣环截面中心的最长距离。 The delivery tube 21 farthest end to the nearest end of the length of the delivery tube 21 is bent section 212 is equal to the maximum radius R of the valve tissue autologous ring as radius of 1/3 of the circumference of a circle, said maximum radius is defined as the cross-sectional direction of the annulus, the annulus to the annulus from the center of the section of the longest distance. 如图6b所示,所述外层管212的远端部分上具有孔,用来固定所述连接线23。 6b, the outer layer having a tube aperture on the distal end portion 212, for fixing the connecting line 23. 如图6a所示,所述锚定件112和所述推杆22被预先放置于所述输送管21的所述内层管211中,所述锚定件121的所述防脱端1123位于所述推杆22远端。 6a, the anchor member 112 and the push rod 22 is previously placed in the inner tube 211 of the delivery tube 21, the anchor member 121 of the retaining ends 1123 located the distal end of push rod 22. 如图6g所示,所述推杆22的远端设置有具有外螺纹的金属头223,与所述锚定件112的防脱端1123可拆卸连接,所述推杆22由双层螺旋编织丝制成,可以传递扭矩,内衬有形状记忆合金镍钛丝,远端部分被预热定形成具有一定的角度来实现所述锚定件释放装置2的远端部分具有预设的形状。 The distal end shown in FIG. 6g, the push rod 22 is provided with an anti-metal head having an external thread 223, 112 with the anchor member 1123 is detachably connected to an end of the release, the push rod 22 by a double helical braid made of wire, the torque can be transmitted, lined with nickel-titanium shape memory alloy wire, the distal end portion is pre-shaped to a distal end portion having a predetermined angle to achieve the anchoring member 2 having a release means a predetermined shape. 当所述锚定件释放装置被释放时,所述推杆22可以恢复成以所述自体瓣膜组织环的最大半径R为半径做的圆的1/4个圆弧形状。 When the anchor release means is released, the push rod 22 to be restored to the native valve tissue annulus of a maximum radius R is the radius of a circle made 1/4 circular arc shape.

[0077] 如图6c所示,推动所述推杆22,使得所述锚定件112被推出所述内层管211的远端,此时所述锚定件112的最远端1121穿过所述假体固定件111,刺入自体组织4,所述锚定件112的远端部分恢复其预设的形状。 [0077] As shown in FIG 6C, pushing the push rod 22, so that the anchor member 112 is pushed out of the distal end of the inner tube 211, in which case the anchor member 112 through the distal-most end 1121 the prosthesis fixing member 111, autologous tissue piercing 4, the distal end portion of the anchor member 112 fixed to restore its preset shape. 如图6d所示,通过控制所述输送管操作件(未示出),后撤所述内层管211,释放所述输送管21与所述阻止瓣膜反流的假体1的可拆卸连接23。 , The operation of the delivery tube by a control member (not shown), the inner tube 211 to retreat, releasing the prosthesis delivery tube 21 is removably blocking the valvular regurgitation 6d 1 are connected as twenty three. 如图6e所示,通过控制所述输送管操作件(未示出),后撤所述外层管212,使所述连接线23的一端被抽离直至与所述固定件111分离。 As shown in FIG 6E, by controlling operation of the delivery tube (not shown), the outer tube 212 to retreat, the connecting cord 23 is pulled up to separate the fixing member 111. 如图6f-6g所示,通过操作所述输送系统4的操作件,使所述推杆22扭转,从而使所述防脱端1123和所述推杆远端的金属头223 的可拆卸连接被拆除,释放所述防脱端1123,使所述阻止瓣膜反流的假体1牢固紧扣在二尖瓣的瓣环上,继续撤回所述释放装置2和输送系统3,完成植入过程。 As shown in FIG. 6f-6g, the delivery system by operating the operation member 4, the push rod 22 to reverse, thereby removably retaining said end 1123 and distal end of the push rod 223 is connected to the metal head were removed, releasing the retaining end 1123, the prosthetic valve to prevent regurgitation 1 securely fastening the mitral valve ring, continuing to withdraw the releasing means 2 and the delivery system 3, to complete the implantation process .

[0078] 具体实施例五: [0078] DETAILED Example Five:

[0079] 优选的,所述锚定件112可以有多种预设的形状,如图7a,所述锚定件112的远端部分被预定形为弧线与直线的组合形,还带有一个倒刺,增加所述锚定件112的锚定效果; 如图7b所示,所述锚定件的最远端1121的形状被设计成带有防脱台阶;如图7c所示,所述锚定件112的远端部分1122被预定形为弧形,还带有两个倒刺,所述防脱端1123由所述锚定件112的远端部分1122进一步延伸而来;如图7d所示,所述锚定件112的最远端1121 为尖锐状,所述锚定件112的远端部分1122被预定形为螺旋形,所述防脱端1123为内部含有不锈钢螺纹的不锈钢管,在另外的优选实施例中,所述锚定件112可以由弹性合金制成, 被预先切割成远端部分为弧形(未示出)。 [0079] Preferably, the anchor member 112 can have a variety of preset shapes, as shown in FIG 7a, the distal portion of the anchor member 112 is formed to a predetermined combination of the linear arc-shaped, also with a barb, increased anchor effect of the anchor member 112; FIG. 7b, the shape of the distal-most end of the anchor member 1121 is designed with retaining step; FIG. 7c, the said anchor member distal portion 112 of a predetermined shape is an arc 1122, with two further barb 1123 from the end of the retaining portion 112 of the distal anchor member 1122 extends further from the fixed; FIG. 7d, the anchor member 112 of the distal-most end 1121 of a sharp shape, the distal end 112 of the anchor member 1122 is part of a predetermined shape in a spiral shape, said retaining end 1123 containing an internal threaded stainless steel tube, in a further preferred embodiment, the anchoring member 112 may be made of an elastic alloy distal section is pre-cut in an arc (not shown).

[0080] 具体实施例六: [0080] DETAILED Example VI:

[0081] 图8a-图8e示出了所述阻止瓣膜反流的假体1的多种实施方式。 [0081] FIG FIGS 8a- 8e illustrates various embodiments of the blocking prosthetic valve regurgitation 1. 如图8a所示, 所述阻止瓣膜反流的假体1,包括固定单元11、连接件12和助闭件13,所述固定单元11包括固定件111和至少两个锚定件112,所述固定件111具有骨架结构并且被部分覆膜,所述固定件111通过所述锚定件112被固定在患者心房壁上或者瓣环上。 As shown in FIG 8a, valvular regurgitation preventing the prosthesis 1, comprising a fixing unit 11, the connecting member 12 and the closure member 13 co, the fixing unit 11 includes a fixing member 111 and at least two anchors 112, the said fixing member 111 has a skeleton structure and is partially covered, the fixing member 111 fixed member 112 is fixed to the atrial wall of a patient or through the anchor annulus. 所述连接件12的远端部分与所述固定件111的近端部分相连,所述连接件12的近端部分与所述助闭件13的远端部分相连,所述连接件12为柔性,所述连接件12的远端延伸出多根线绕接在所述固定件111的近端部分上,所述助闭件13的远端延伸出多根线绕接在所述连接件12的近端部分上,优选的,所述线从所述助闭件13 -直延伸至所述固定件111上。 The connecting member 12 is connected to the distal portion of the proximal end portion of the fixing member 111, the connecting member 12 is connected to the proximal portion of the distal end portion 13 co-closing member, the connector member 12 is a flexible the connecting member 12 extends out the distal end of a plurality of wound contact with the proximal portion of the fixing member 111, the distal end of the co-closing member 13 extending in a plurality of wound contact member 12 connected to the the proximal portion, preferably, the wire 13 from the closing aid - direct extending to the fixing member 111. 在所述助闭件13和所述固定件111之间具有供血液流过的通道121,优选的,所述助闭件13为柱状,其横截面为椭圆形,使得所述助闭件13能够最大化地贴合患者自身瓣叶。 Having a supply of blood to flow through passage 121, preferably between the promoter and the closing member 13 of the fixing member 111, the closure member 13 co-columnar shape whose cross section is oval, such that the closure member 13 co to maximize fit the patient's own leaflets. 如图8b所示,所述固定件111为高分子片,所述锚定件112通过线1124与所述固定件111连接,所述连接件12为条状,由多股高分子线绕制而成,所述连接件12的两侧为血液流过的通道,所述助闭件13为单片状,所述固定件111通过所述连接件12与所述助闭件13连接。 8b, the fixing member 111 is a polymer sheet, the anchor 111 is connected via line 112 to the fixing member 1124, the connecting member 12 is strip-shaped, multi-strand wire wound polymer made, on both sides of the channel member 12 is connected to the blood flow through the aid of a single sheet-like closing member 13, the fixing member 111 of the connecting member 12 is connected to the closing member 13 by aid. 如图8c所示,所述锚定件112与所述固定件111为一体结构,所述连接件12为两根丝,所述连接件12的远端连接在所述锚定件112上,所述连接件12的近端连接在所述助闭件13上,所述助闭件13为单片与筒状的组合。 Shown in Figure 8c, the anchor member 112 and the fixing member 111 as an integral structure, the two wires of the connection member 12, the distal end of the connecting member 12 is connected to the anchor member 112, the proximal end of the connecting member 12 is connected to the closure member 13 co, closing member 13 to the co cylindrical monolithic combination. 如图8d所示,所述固定件111上被部分覆膜,便于所述锚定件112的固定,所述助闭件13上设置有调整结构132,所述调整结构132为金属丝或高分子线,所述金属丝或高分子线的一端连接在所述助闭件13上,所述金属丝或高分子线的另一端连接在心室或者心尖上,这样设计的好处在于医生可以在术中调整所述金属丝或高分子线,使瓣膜反流达到最小值时再将所述金属丝或高分子线的另一端固定在心室或者心尖上,在所述助闭件13的近端还设置有展开装置131,所述展开装置131为由金属记忆材料丝绕制而成的波浪形结构或锯齿形结构,便于所述助闭件13展开。 Shown, the fixing member is coated portion 111, facilitates the anchoring of the fixing member 112, the co-closing member 132 is provided with adjustment structures 13, the adjustment structure 132 is a metal wire or high in FIG. 8d molecular wire, the wire or cable is connected to one end of the polymer of the benefits of co-closing member 13, the other end of the wire or cable is connected to the polymer or ventricular apex, so that the physician can design technique adjust the wire or a polymer wire, so that when the valve reaches a minimum and then reflux the further wire or a polymer wire end is fixed on the apex or ventricle, the proximal end of the further closure member 13 co is provided with a deployment device 131, the deployment device 131 by the wavy or zigzag-shaped configuration memory material structural metal wire winding made to facilitate the co-closing member 13 is expanded. 如图8e所示,所述固定件111具有骨架结构,所述骨架结构为网格状支架,所述骨架结构被覆膜,所述锚定件112与所述膜连接,所述助闭件13为单片与球囊的组合,所述球囊表面为疏孔材料,里面含有吸水膨胀材料,其在血液中膨胀后能与患者瓣叶贴合,用于治疗反流面积较大的患者。 As shown in FIG. 8e, the fixing member 111 has a skeleton structure, the skeleton structure is a grid-shaped bracket, the skeletal structure is coated, the anchor member 112 is connected with the membrane, the closure member co 13 is a monolithic combination of the balloon, the balloon surface is a hydrophobic porous material, which contains water-swellable material, after expansion, which can be bonded in blood with a patient leaflet, for treating patients with reflux larger area .

[〇〇82] 最后应当说明的是,以上所述仅为本发明的较佳的实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。 [〇〇82] Finally, it should be noted that the above-described preferred embodiment of the present invention only but are not intended to limit the present invention, any modifications within the spirit and principle of the present invention, equivalent replacements and modifications shall fall within the protection scope of the present invention.

Claims (15)

1. 一种带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于,包括阻止瓣膜反流的假体和锚定件释放装置,所述阻止瓣膜反流的假体包括固定单元、连接件和助闭件,所述固定单元包括固定件和锚定件,所述连接件的远端部分与所述固定件的近端部分相连,所述连接件的近端部分与所述助闭件的远端部分相连,所述连接件为柔性,使得所述连接件以及与之相连的所述助闭件能够随着瓣叶的运动而运动,所述固定件通过所述锚定件被固定在患者心房壁上或者瓣环上,所述助闭件在自由状态时位于患者自体瓣叶之间,所述锚定件的远端部分具有预设的形状,所述锚定件的近端设置有防脱端;所述锚定件释放装置包括输送管和推杆,所述锚定件释放装置与所述固定单元可拆卸连接,所述锚定件释放装置的远端部分具有预设的形状,使得所述输送管的 An anchoring device with a system for preventing regurgitation valve repair, wherein a prosthetic valve including preventing regurgitation and the anchor release means, said fixing means prevents the prosthetic valve regurgitation comprising connecting members and co-closing member, the fixing unit comprises a fixing member and an anchoring member connected to the proximal portion of the distal end portion of the fixing member connecting member, said connecting member and said proximal portion the distal end portion of aid closing member is connected to said flexible connecting member, such that said connecting member and said closing member co-connected thereto with the movement of the flap can be moved, the fixing member by the anchor member is fixed to the atrial wall of the patient or the annulus, the closure member co-located in the free state of the patient from the leaflet between the body, the distal end portion of said anchor member having a predetermined shape, the anchoring member the proximal end is provided with a retaining; the anchor release means comprises a delivery tube and a pusher, said anchor member and said release means fixing unit detachably connected to a distal end portion of a given anchor member release device having a predetermined shape such that the delivery tube 端部分能够整体弯曲或部分弯曲,以便于在所述锚定件被移动之前所述输送管的最远端紧抵所述固定单元或者紧抵自体组织, 在所述输送管的最远端设置有刚性段,所述锚定件以伸展状态被预先装入所述输送管的远端部分内,所述推杆被放置在所述输送管内,所述锚定件位于所述推杆的远端,推动所述推杆能够使所述锚定件向所述输送管的远端移动,所述锚定件被推出所述输送管后,所述锚定件的远端部分能够恢复其预设的形状,所述锚定件将所述阻止瓣膜反流的假体固定在所述自体组织与所述锚定件的所述防脱端之间。 The bent end portion can be entirely or partially curved, so as to abut against the distal-most before the anchoring member is moved to said delivery tube tightly against the fixed unit or autologous tissue, distal-most end of the delivery tube disposed rigid section of the anchor member in a stretched state is previously loaded within the distal end portion of the delivery tube, the plunger is disposed within the delivery tube, the anchor member is located distal of the push rod end, the push rod capable of pushing the anchor member moves distally of the delivery tube, the anchor member is pushed after the predetermined delivery tube, the distal end portion of the anchor can recover its pre- setting a shape of said anchor member to prevent the prosthetic valve regurgitation autologous tissue is fixed to the end of said retaining member between said anchor.
2. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述输送管能够弯曲的部分为弯曲段,所述输送管的最远端到所述输送管的所述弯曲段的最近端之间的长度大于或等于以患者自体瓣膜组织环的最小半径做的圆的周长的六分之〇 The belt anchoring device of claim 1 for preventing valvular regurgitation repair system, characterized in that the duct portions can be bent to a curved segment, the furthest end of the delivery tube as claimed in claim sixty per circumference of a circle of length between the nearest end of the curved section of said delivery tube is greater than or equal to the minimum radius of the valve tissue autologous rings do
3. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述固定件展开的宽度小于瓣膜组织环周长的三分之二。 3. The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, wherein said fixing member is smaller than the width of the expanded two-thirds of the circumference of the valve tissue annulus.
4. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述的助闭件的最大宽度小于单个所述自体瓣叶展开的最大宽度。 4. The belt according to claim 1 for preventing anchoring means regurgitation valve repair system, wherein said closing member co-maximum width smaller than the maximum width of a single leaflet of the self-deployed.
5. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述助闭件为单片、多片、筒状、袋状、柱状或球囊,或者所述助闭件为单片与多片的组合, 或者所述助闭件为单片与筒状的组合,或者所述助闭件为单片与袋状的组合,或者所述助闭件为单片与柱状的组合,或者所述助闭件为单片与球囊的组合。 The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, wherein said co-closing member as a single piece, multi-piece, tubular, bag-like, columnar or balloon or the co-closing member as a single piece with a combination of multiple pieces, or a combination of the co-closing member is a single piece with a cylindrical, or the co-closing member as a single piece with the bag-like composition, or the co- the closing member is a monolithic combination of a columnar, or the co-closing member as a single piece with the balloon combination.
6. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述助闭件的近端设置有展开装置,所述展开装置由金属丝或高分子线制成。 The belt anchor according to claim 1 for preventing valvular regurgitation repair system of a given apparatus, wherein the proximal end of the closure member co-deployment device is provided with the deployment means by a wire or high molecular lines are made.
7. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述助闭件上连接有调整结构,所述调整结构为金属丝或高分子线,所述金属丝或所述高分子线的一端连接在所述助闭件上,所述金属丝或所述高分子线的另一端连接在心室或者心尖上,通过调整所述金属丝或所述高分子线的两端之间的距离,来调整所述助闭件的阻反流的效果。 According to claim 1 with an anchoring means for preventing regurgitation valve repair system of claim, wherein said closure member is connected to co-adjust the structure, the adjustment structure is a metal wire or a polymer wire , the wire or wires connected to one end of the polymer in the co-closing member, the other end of the wire or the wire is connected to the polymer or ventricular apex, the wire or by adjusting the polymer distance between the ends of said line, to adjust the effect of co-reflux barrier closing member.
8. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述锚定件与所述固定件连接,所述锚定件释放装置与所述固定单元的可拆卸连接通过所述锚定件与所述锚定件释放装置的可拆卸连接来实现。 8. The belt according to claim 1 anchor setting means for preventing regurgitation valve repair system, wherein said anchor member is connected to the stationary member, said anchor member and said release means detachable fixing unit is connected to the anchor member with the anchor member is detachably connected to release means to achieve.
9. 根据权利要求8所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述锚定件与所述固定件为一体结构。 9. The tape of claim 8, wherein the anchoring means for preventing regurgitation valve repair system, wherein said anchor member and said fixing member is a unitary structure.
10. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 在所述助闭件和所述固定件之间具有供血液流过的通道。 10. The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, characterized by having a passage for blood to flow through between the promoter and the closing member holder.
11. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述输送管的所述刚性段的长度大于或等于所述锚定件的全长的十分之一。 With an anchoring device according to claim 1 for preventing regurgitation valve repair system, characterized in that the length of the rigid section of the duct is greater than or equal to the entire length of anchor one-tenth.
12. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述输送管的远端部分被预定形,使得所述推杆的远端部分能够随着所述输送管的被预定形的远端部分弯曲,或者所述推杆的远端部分被预定形,所述输送管的所述远端部分随所述推杆被预定形的形状弯曲,或者所述输送管和所述推杆的远端部分均被预定形,使得所述输送管的远端部分与所述推杆的远端部分一起弯曲。 12. The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, wherein a distal portion of the delivery tube is pre-shaped such that the distal end portion of the plunger can be as the conveyor is bent a predetermined portion of the tube-shaped distal end, or distal end portion of the push rod a predetermined shape, the distal end portion of the delivery tube with the push rod is bent a predetermined shape or the distal portion of the delivery tube and the push rod are pre-shaped such that the distal portion of the delivery tube with the curved distal portion of the pusher.
13. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述推杆与所述锚定件的所述防脱端可拆卸连接。 13. The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, characterized in that the pusher member with the anchor end retaining said detachable connection.
14. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述带锚定装置的用于阻止瓣膜反流的修复系统还包括支撑装置和支撑装置操作件,所述支撑装置操作件与所述支撑装置的近端固定连接,所述支撑装置的远端部分能够弯曲,使得所述支撑装置被释放后,所述支撑装置的所述远端部分抵住自体组织。 14. The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, characterized in that said belt anchor means for preventing regurgitation valve repair system further comprises a support means and a support after the operating member means, said proximal end of said support means and operating member is fixedly connected to the supporting means, the distal end portion of the support means capable of bending, so that the support means is released, the distal end of said support means part of the body tissue against the self.
15. 根据权利要求1所述的带锚定装置的用于阻止瓣膜反流的修复系统,其特征在于, 所述带锚定装置的用于阻止瓣膜反流的修复系统还包括支撑装置和输送系统,所述输送系统包括引导头、外鞘管、鞘芯和操作件,所述鞘芯被设置在外鞘管内,所述鞘芯的远端与所述引导头固定连接,所述鞘芯的近端与所述操作件固定连接,所述心脏瓣膜假体、所述锚定件释放装置和所述支撑装置均被设置在所述外鞘管与所述鞘芯之间,所述支撑装置的近端与所述输送系统的所述操作件固定连接,或者所述支撑装置的远端与所述输送系统的所述引导头固定连接,或者所述支撑装置的近端与所述输送系统的所述操作件固定连接并且所述支撑装置的远端与所述输送系统的所述引导头固定连接,当所述锚定件释放装置被释放时,所述支撑装置给予所述锚定件释放装置支撑 15. The tape of claim 1, wherein the anchoring means for preventing regurgitation valve repair system, characterized in that said belt anchor means for preventing regurgitation valve repair system further comprises a support and transport means system, the delivery system includes a guide head, the outer sheath, the core and the sheath operating member, the sheath of the core tube is disposed within the outer sheath, the distal end of the sheath core is fixedly connected with the guide head, the sheath core a proximal end fixedly connected with the operating member, the heart valve prosthesis, the anchoring member supporting means and said release means are disposed between the outer sheath and the sheath core, said support means the proximal end of the delivery system of the operating member is fixedly connected to the support means or the distal end of the delivery system of the guide head is fixedly connected to the proximal end of the support means or with the delivery system the operating member is fixedly connected to said support means and the distal end of the delivery system and the fixed guide head is connected to the anchoring member when the release means is released, the support means administering to said anchor member release means supporting .
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016004798A1 (en) * 2014-07-07 2016-01-14 宁波健世生物科技有限公司 Prosthesis for preventing valve regurgitation
WO2016004799A1 (en) * 2014-07-07 2016-01-14 宁波健世生物科技有限公司 Cardiac valve implantation instrument with anchoring device
CN107205822A (en) * 2015-02-12 2017-09-26 美敦力公司 Integrated valve assembly and method of delivering and deploying an integrated valve assembly

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033398A1 (en) * 2001-07-31 2005-02-10 Jacques Seguin Assembly for setting a valve prosthesis in a corporeal duct
US20080058868A1 (en) * 2003-12-19 2008-03-06 John To Devices and methods for anchoring tissue
CN102133119A (en) * 2004-02-25 2011-07-27 阿普特斯内系统公司 Systems and methods for attaching a prosthesis within a body lumen or hollow organ
US20130023985A1 (en) * 2011-01-28 2013-01-24 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
CN103079498A (en) * 2010-05-05 2013-05-01 内奥瓦斯克公司 Transcatheter mitral valve prosthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033398A1 (en) * 2001-07-31 2005-02-10 Jacques Seguin Assembly for setting a valve prosthesis in a corporeal duct
US20080058868A1 (en) * 2003-12-19 2008-03-06 John To Devices and methods for anchoring tissue
CN102133119A (en) * 2004-02-25 2011-07-27 阿普特斯内系统公司 Systems and methods for attaching a prosthesis within a body lumen or hollow organ
CN103079498A (en) * 2010-05-05 2013-05-01 内奥瓦斯克公司 Transcatheter mitral valve prosthesis
US20130023985A1 (en) * 2011-01-28 2013-01-24 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016004798A1 (en) * 2014-07-07 2016-01-14 宁波健世生物科技有限公司 Prosthesis for preventing valve regurgitation
WO2016004799A1 (en) * 2014-07-07 2016-01-14 宁波健世生物科技有限公司 Cardiac valve implantation instrument with anchoring device
CN107205822A (en) * 2015-02-12 2017-09-26 美敦力公司 Integrated valve assembly and method of delivering and deploying an integrated valve assembly

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