CN104041811B - A kind of Taurine improving male's sexual and semen quality - Google Patents

Abstract

The invention relates to the field of health food, and specifically provides a taurine compound preparation for improving male sexual function and semen quality. The active ingredients of the compound preparation are composed of the following raw materials in the weight ratio: 5-60 parts of taurine, 10-40 parts of arginine, 5-30 parts of zinc and 5-30 parts of vitamin C. The compound preparation of the invention has been proved by clinical tests to have no toxic effect on the body and can be used safely. The compound preparation of the invention has the functions of anti-oxidation, anti-fatigue, and improving immunity, especially in improving male sexual function and semen quality.

Description

A taurine compound preparation for improving male sexual function and semen quality

technical field

The invention relates to the field of health food, in particular to a taurine compound preparation for improving male sexual function and semen quality.

Background technique

At present, male reproductive health is a hot issue of concern to the whole society. The United Nations Special Program clearly pointed out: Emphasis on reproductive health and reproductive health care services is an inevitable trend in the progress of civilization in human society. At the "International Conference on Population and Development" held in Cairo in September 1994, representatives of more than 180 countries unanimously recognized the importance of male reproductive health, and decided to include "reproductive health" as "the most important issue in the world" In the "Action Plan" formulated by the General Assembly, the heads of governments of all countries are required to make a commitment to ensure that "everyone has access to reproductive health care services in the 21st century". The World Health Organization (WHO) has also decided to designate the 21st century as the "reproductive health century". my country's Family Planning Commission made a decision in 2000 to set October 28th as "Men's Health Day" to remind the whole society to pay attention to men's health, especially male reproductive health. The focus of male reproductive health research is to prevent reproductive function decline and improve reproductive performance.

Male reproductive function mainly includes the evaluation of sexual function and semen quality. Sexual function refers to the ability of sexual activity, which is the main index to measure the strength of male reproductive function. Sexual activity includes penile erection, penetration, ejaculation, etc., among which penile erection is the basis for normal sexual activity. The process of penile erection shows that under the guidance of sexual stimulation, the small arteries in the cavernous body and the smooth muscle in the wall of the cavernous sinus relax, the blood flow into the cavernous body increases, the pressure in the cavernous body increases, and the venous plexus of the subwhite membrane and the perforating vein are compressed. The outflow of venous blood from the cavernous bodies decreases and erections occur. During this process, it is generally believed that the activation of non-cholinergic and non-adrenergic nerve endings and the increase in the release of nitric oxide (NO) to promote the relaxation of arterioles and cavernous smooth muscle are the main mechanisms leading to penile erection. Androgen is an essential hormone to maintain sexual desire, and can regulate penile erection through both central and peripheral aspects, and can facilitate erection. Semen quality includes indicators such as sperm count, motility rate, motility rate, deformity rate, and acrosome integrity rate. The quality of semen directly affects the reproductive ability of men. Poor semen quality is one of the main factors leading to male infertility today. Male reproductive function is affected by factors such as heredity, environment, diet and age.

At present, although there have been drugs or compound preparations to improve male sexual function and semen quality, these drugs have complicated formulas, poor pertinence, unsatisfactory effects, and the main effect drugs are not prominent enough, and certain side effects will occur after long-term use.

Contents of the invention

In order to solve the problems in the prior art, the object of the present invention is to provide a taurine compound preparation with simple formula, safety and no side effects, which can obviously improve male sexual function and improve semen quality.

In order to achieve the purpose of the present invention, the present invention provides a taurine compound preparation for improving male sexual function and semen quality, which is characterized in that the active ingredients of the compound preparation are composed of the following raw materials in weight ratio: taurine 5～ 60 parts, 10-40 parts of arginine, 5-30 parts of zinc and 5-30 parts of vitamin C.

Preferably, the active ingredients of the compound preparation are composed of the following raw materials in weight ratio: 20-60 parts of taurine, 15-35 parts of arginine, 15-25 parts of zinc and 10-20 parts of vitamin C.

More preferably, the active ingredients of the compound preparation consist of the following raw materials in weight ratio: 50 parts of taurine, 25 parts of arginine, 20 parts of zinc and 15 parts of vitamin C.

The effects of the above active ingredients are as follows:

Taurine is one of the most abundant free amino acids in the gonads and germ cells of the body, and plays an important role in the reproductive function of the body. Taurine is a sperm motility agonist. Adding taurine to semen can increase the survival time of sperm in vitro and maintain the normal movement of sperm; adding taurine to semen diluent can increase the survival rate of sperm in frozen semen and increase sperm motility. Testicular tissue can biosynthesize taurine. Supplementing the body with taurine can promote the secretion of testosterone and significantly improve the quality of semen; it can also increase the content of NO in the body and significantly enhance the sexual function of aged male rats.

Arginine is the main component of sperm protein, which can promote the production and metabolism of sperm, and can be used as an energy source for sperm movement. Arginine is the precursor of NO biosynthesis in the body, and NO not only participates in the regulation of testicular microcirculation and the secretion of testosterone, but also promotes and regulates spermatogenesis and motility.

Zinc is an essential trace element for the human body, and its content is relatively high in the male prostate, testis and semen. It participates in the development of gonads, sperm production, maturation, capacitation and acrosome reaction in the form of enzymes. Zinc can affect the function of the hypothalamus-pituitary-testis axis, promote the secretion of testosterone, and then affect the development of gonads and sperm production. Zinc can protect sperm by anti-lipid peroxidation, and regulate sperm motility by regulating sperm phospholipid metabolism.

Vitamin C, also known as ascorbic acid, is a good antioxidant and participates in many important metabolisms in the human body. Vitamin C levels in the semen of infertile men were significantly lower. Supplementing vitamin C in food can improve the viability and motility of sperm in men over 25 years old, increase the number of mature sperm, and reduce the rate of sperm deformity.

Further, the dosage forms of the aforementioned compound preparations are tablets, capsules, granules and granules.

As a preference, the dosage forms of the aforementioned compound preparations are tablets and capsules. The specific preparation method of the compound preparation is as follows: 1. Weigh the raw materials according to the ratio, mix them, and set aside; 2. Pack them into capsules; or mix them with common auxiliary materials for tablets (starch, plant cellulose, etc.), and press them into tablets.

Wherein, the mass percentage of the active ingredients in the compound preparation is not less than 80%.

The invention also provides the application of the compound preparation in improving male sexual function.

The invention also provides the application of the compound preparation in improving the quality of semen.

The beneficial effects of the present invention are:

The taurine compound preparation for improving male sexual function and semen quality described in the present invention has a simple formula, has no toxic effect on the body as proved by clinical tests, and can be used safely. The compound preparation of the invention has the functions of anti-oxidation, anti-fatigue, and improving immunity, especially in improving male sexual function and semen quality.

detailed description

The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

Example 1

Mix 500mg of taurine, 250mg of arginine, 200mg of zinc and 150mg of vitamin C, pack into capsules, 1g of each powder.

Example 2

Mix 200mg of taurine, 350mg of arginine, 150mg of zinc and 200mg of vitamin C, put into capsules, 1g of each medicine powder.

Example 3

Mix 600mg of taurine, 150mg of arginine, 250mg of zinc, and 100mg of vitamin C, and pack into capsules, 1g of each medicine powder.

Example 4

Mix 50mg of taurine, 400mg of arginine, 300mg of zinc and 300mg of vitamin C, put into capsules, 1g of each powder.

Example 5

Mix 600mg of taurine, 100mg of arginine, 50mg of zinc and 50mg of vitamin C, put into capsules, 1g of each powder.

In order to verify the effect of the taurine compound preparation for improving male sexual function and semen quality provided by the present invention, the present inventor has carried out clinical curative effect verification to the medicament that above-mentioned embodiment 1,2,3,4 and 5 make, The experimental methods and results are as follows.

1. Test method

1.1 Treatment of erectile dysfunction trials

Select 120 cases of patients with clinically diagnosed erectile dysfunction (ED) to carry out the test, and randomly divide them into 6 groups, 20 cases in each group, wherein the first group is the control group, which is given starch capsule preparation; the second, third, fourth, fifth, and sixth Group is test group 1,2,3,4,5, gives embodiment 1,2,3,4,5 capsule preparation respectively, every day divides 2 times (morning and evening each 1 time) and takes capsule preparation, each time 3 capsules , taking it continuously for 2 months, and inquiring about its therapeutic effect. The therapeutic effect is divided into three levels: ① significant curative effect (the penis can be erected normally before intercourse, and can have sex, and the feeling lasts longer than before the disease), ②The treatment is effective (the penis can be erected normally before intercourse, and can have sexual life, but the feeling is not firm), ③ineffective (the penis can be erected normally or the erection time is very short before intercourse, and normal sexual life is still not possible).

1.2 Treatment of low quality semen test

Select 120 patients with clinically confirmed low semen quality (not caused by varicocele and congenital diseases, sperm count less than 20 million/ml, sperm motility <30%. Sperm motility grade A <10% or grade A+B Grade <25%) patients were tested, randomly divided into 6 groups, 20 examples in each group, wherein the first group was the control group, given starch capsule preparation; the second, third, fourth, fifth and sixth groups were the experimental groups 1, 2, 3, 4, 5, give respectively the capsule preparation of embodiment 1, 2, 3, 4, 5, and each person takes the capsule preparation in 2 times (morning and evening respectively) every day, 3 capsules each time, taking continuously for 4 months After that, the semen is collected and the quality of the semen is checked. The treatment effect is divided into three levels: significant treatment (sperm count > 40 million/ml, sperm motility rate > 50%. Sperm motility grade A > 20% or grade A + B > 40%), effective treatment (sperm count, sperm motility Motility rate, sperm motility at least one index is higher than before treatment), treatment is ineffective (no improvement or decline in semen quality).

2. Test results

2.1 Treatment effect of erectile dysfunction

Taurine compound preparation is shown in Table 1 to the therapeutic effect of erectile dysfunction, as can be seen from Table 1, the taurine accordant preparation provided by the present invention has good effect for the treatment of ED, and with the best effect of Example 1, the effective rate reaches 90%. %.

The effect of table 1 taurine compound preparation on treating erectile dysfunction (unit: people, n=20)

group Significant effect effective treatment Ineffective treatment control group 0 2 18 Test group 1 12 6 2 Test group 2 7 9 4 Test group 3 8 8 4 Test group 4 6 6 8 Test group 5 5 8 7

2.2 Treatment effect of low semen quality

The taurine compound preparation is shown in Table 2 to the low therapeutic effect of semen quality, as can be seen from Table 2, the taurine conforming preparation provided by the present invention has good effect for the treatment of low semen quality, and the effect is the best with embodiment 1, effective rate up to 90%.

Table 2 The effect of taurine compound preparation on treating low semen quality (unit: person, n=20)

group Significant effect effective treatment Ineffective treatment control group 1 3 16 Test group 1 13 5 2 Test group 2 9 7 3 Test group 3 7 10 3 Test group 4 5 8 7 Test group 5 6 7 7

Although the present invention has been described in detail with general descriptions and specific embodiments above, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, the modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the protection scope of the present invention.

Claims (4)

1. a taurine compound preparation improving male sexual function and semen quality, is characterized in that, the active ingredient of described compound preparation is made up of the raw material of following weight ratio: 50 parts of taurine, 25 parts of arginine, 20 parts of zinc and 15 parts of vitamin C. 2. The compound preparation according to claim 1, characterized in that, the dosage form of the compound preparation is tablet, capsule, granule and electuary. 3. compound preparation according to claim 2, is characterized in that, the dosage form of described compound preparation is tablet and capsule. 4. The compound preparation according to claim 2, characterized in that, the mass percentage of the active ingredients in the compound preparation is not less than 80%.