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An implantable bioartificial renal device

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Publication number
CN103977465B
CN103977465B CN 201410039297 CN201410039297A CN103977465B CN 103977465 B CN103977465 B CN 103977465B CN 201410039297 CN201410039297 CN 201410039297 CN 201410039297 A CN201410039297 A CN 201410039297A CN 103977465 B CN103977465 B CN 103977465B
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CN 201410039297
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CN103977465A (en )
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徐高四
黄天伦
叶婷
严文君
刘惠欣
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南昌大学第二附属医院
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Abstract

一种植入式生物人工肾装置,它涉及医疗用品技术领域。 An implantable bioartificial kidney device, which involves medical supplies technology. 植入式生物人工肾本体(1)的内部设置有纳米级聚乙烯乙二醇硅颗粒膜(3),纳米级聚乙烯乙二醇硅颗粒膜(3)的外侧设置有肾小管上皮细胞层(2),植入式生物人工肾本体(1)的一端与动脉端(4)连通,植入式生物人工肾本体(1)的另一端与静脉端(5)连接,且尿液流出通道(6)的一端与植入式生物人工肾本体(1)相连接。 Implantable bioartificial kidney inside the body (1) is provided with a nanoscale silicon particles polyethylene glycol film (3), outside of nanoscale silicon particles polyethylene glycol film (3) is provided with a layer of renal tubular epithelial cells (2), implantable bioartificial kidney body (1) and the end of the arterial end (4) communicating implantable bioartificial kidney body (1) and the other end of the venous (5) is connected, and urine outflow channel end (6) is connected to the implantable bioartificial kidney body (1). 它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 Simple structure, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, broaden the range of activity of the patient.

Description

一种植入式生物人工肾装置 An implantable bioartificial renal device

技术领域 FIELD

[0001] 本发明涉及医疗用品技术领域,具体涉及一种植入式生物人工肾装置及其应用。 [0001] The present invention relates to a technical field of medical supplies, particularly relates to a bioartificial kidney An implantable device and its application.

背景技术 Background technique

[0002] 随着社会发展和人民生活习惯的改变,高血压和糖尿病的发生率逐年增高。 [0002] With the changes in the social development and people's living habits, the incidence of hypertension and diabetes increased year by year. 因而,这两种疾病最重要的共同并发症一一慢性肾功能衰竭的发病率也显著上升。 Thus, the two diseases most important common complication eleven incidence of chronic renal failure was also significantly increased. 慢性肾功能衰竭患者最终都要进入到尿毒症期(以下简称尿毒症)。 Chronic renal failure patients eventually will enter into uremia (hereinafter referred to as uremia). 目前世界上对尿毒症的治疗主要有以下三种方式:肾移植、血液透析和腹膜透析。 The world mainly in the following three ways to treat uremia: kidney transplantation, hemodialysis and peritoneal dialysis. 由于全球范围内肾源的缺乏,导致目前不到1%的尿毒症患者能够接受肾移植手术。 Because of the lack of worldwide kidneys, leading to the current less than 1% of uremic patients to receive a kidney transplant.

[0003] 血液透析和腹膜透析虽然能解决尿毒症患者的存活问题,但都由于其自身存在的问题而限制了其临床应用。 [0003] Although hemodialysis and peritoneal dialysis can solve the problem of survival in patients with uremia, but all because of their own problems and limits its clinical application. 比如,血液透析患者目前需要在医院内才能完成治疗,限制了患者的活动范围和上班的问题。 For example, hemodialysis patients currently need to complete treatment in the hospital, limiting the scope of activities and issues of patient work. 另外,腹膜透析治疗虽然能在患者居家进行,但患者出行时需要携带大量的腹膜透析液,很不方便。 In addition, although the peritoneal dialysis treatment can be performed in patients at home, but need to carry large amounts of fluid during peritoneal dialysis patients travel, very convenient.

发明内容 SUMMARY

[0004] 本发明的目的是提供一种植入式生物人工肾装置,它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 [0004] The object of the present invention is to provide an implantable bioartificial renal device, has a simple structure, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, broaden the range of activity of the patient.

[0005] 为了解决背景技术所存在的问题,本发明采用以下技术方案:它包含植入式生物人工肾本体1、肾小管上皮细胞层2、纳米级聚乙烯乙二醇硅颗粒膜3、动脉端4、静脉端5和尿液流出通道6,植入式生物人工肾本体1的内部设置有纳米级聚乙烯乙二醇硅颗粒膜3,纳米级聚乙烯乙二醇硅颗粒膜3的外侧设置有肾小管上皮细胞层2,植入式生物人工肾本体1的一端与动脉端4连通,植入式生物人工肾本体1的另一端与静脉端5连接,且尿液流出通道6 —端与植入式生物人工肾本体1相连接。 [0005] In order to solve the problems of the background art, the present invention employs the following technical solution: that implantable bioartificial kidney comprising a main body 1, two tubular epithelial cell layer, the silicon nano-particle film 3 of polyethylene glycol, arterial end 4, 5 and urine venous outflow passage 6, implantable bioartificial kidney inside the body 1 is provided with a nanoscale silicon particles polyethylene glycol film 3, the silicon nano-particles polyethylene glycol outer film 3 is provided with a tubular epithelial cell layer 2, one end of the implantable bioartificial kidney artery of the body 1 of the communication terminal 4, a body implantable bioartificial kidney and the other end connected to one end 5 of the vein, and urine outflow passage 6 - end 1 is connected to a body implantable bioartificial kidney.

[0006] 本发明的应用方法为:它的动脉端4与肾动脉相连,尿毒症患者的血液经过本植入式生物人工肾本体1的“清洗”后经静脉端5与肾静脉相连的导管回流体内,装置内的血液在体内血压力作用下经过纳米级聚乙烯乙二醇硅颗粒膜3的滤过,形成“原尿”,纳米级聚乙烯乙二醇硅颗粒膜3类似于人类肾小球滤过膜,对于分子量大于4.2万道尔顿的分子起到很好的阻挡作用。 [0006] Application of the method according to the present invention are: its arterial end 4 is connected to the renal arteries, the blood of uremic patients through implantable bioartificial kidney according to "cleanse" the venous catheter 5 after renal vein and connected to body 1 reflux body, the blood in the device at the blood pressure in vivo after filtration nanoscale silicon particles polyethylene glycol film 3, forming the "original urine", nanoscale silicon particles polyethylene glycol film 3 similar to human kidney pellets filtration membrane, the molecular weight greater than 42,000 daltons play a good barrier effect. 与尿毒症患者体内血液成分相比,“原尿”内基本没有大分子成分比如免疫球蛋白等,尿毒症毒素也被滤过到“原尿”中,但其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等与血液相类似。 Compared with the blood of uremic patients components, the "original urine" substantially free of other macromolecular components such as immunoglobulins, uremic toxins to be filtered through the "original urine" but within the amino acid, glucose, a small molecule protein, electrolytes and other blood components, and HC03 similar. “原尿”内的成分经过装置内的肾小管上皮细胞结构2重吸收,其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等又被重新吸收入血,回流至体内。 Component in the "original urine" via tubular epithelial cells within the device structure reabsorption 2, in which the amino acid, glucose, small proteins, HC03 electrolyte components and the like has been re-absorbed into the bloodstream, is returned to the body. “原尿”中的剩余代谢产物、酸性成分等则随尿液流出通道6流至膀胱而排出体夕卜。 The remaining metabolites "original urine" in the acidic components and the like with the flow of urine flow passage 6 and is discharged to the bladder body Bu Xi. 人类肾小管上皮细胞有再生功能,可不断“补充”,而凋亡的肾小管上皮细胞本身和代谢产物则随本装置滤过后产生的“尿液”通过尿液流出通道6排出体外。 Human renal tubular epithelial cells regeneration can continue "complementary", and apoptosis of renal tubular epithelial cells with itself and metabolites are present after the filtration apparatus resulting "urine" excreted in the urine outflow passage 6.

[0007] 本发明具有以下有益效果:它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 [0007] The present invention has the following advantages: simple structure, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, broaden the range of activity of the patient.

[0008] 附图说明: [0008] BRIEF DESCRIPTION OF DRAWINGS:

[0009] 图1为本发明的结构示意图。 [0009] FIG. 1 is a schematic structural diagram of the present invention.

[0010] 具体实施方式: [0010] DETAILED DESCRIPTION:

[0011] 参照图1,本具体实施方式采取以下技术方案:它包含植入式生物人工肾本体1、肾小管上皮细胞层2、纳米级聚乙烯乙二醇硅颗粒膜3、动脉端4、静脉端5和尿液流出通道6,植入式生物人工肾本体1的内部设置有纳米级聚乙烯乙二醇硅颗粒膜3,纳米级聚乙烯乙二醇硅颗粒膜3的外侧设置有肾小管上皮细胞层2,植入式生物人工肾本体1的一端与动脉端4连通,植入式生物人工肾本体1的另一端与静脉端5连接,且尿液流出通道6 —端与植入式生物人工肾本体1相连接。 [0011] Referring to FIG. 1, the specific embodiment according to the present embodiment take the following aspect: that implantable bioartificial kidney comprising a main body 1, two tubular epithelial cell layer, the silicon nano-particle film 3 of polyethylene glycol, arterial end 4, 5 and urine venous outflow passage 6, implantable bioartificial kidney inside the body 1 is provided with a polyethylene glycol nanoscale silicon particles 3 film, polyethylene glycol nanoscale silicon particles 3 are provided outside the membrane renal tubule epithelial cell layer 2, one end of the implantable bioartificial kidney artery of the body 1 of the communication terminal 4, a body implantable bioartificial kidney and the other end connected to one end 5 of the vein, and urine outflow passage 6 - end of the implant biological artificial kidney is connected to the main body 1.

[0012] 本具体实施方式的应用方法为:它的动脉端4与肾动脉相连,尿毒症患者的血液经过本植入式生物人工肾本体1的“清洗”后经静脉端5与肾静脉相连的导管回流体内,装置内的血液在体内血压力作用下经过纳米级聚乙烯乙二醇硅颗粒膜3的滤过,形成“原尿”,纳米级聚乙烯乙二醇硅颗粒膜3类似于人类肾小球滤过膜,对于分子量大于4.2万道尔顿的分子起到很好的阻挡作用,与尿毒症患者体内血液成分相比,“原尿”内基本没有大分子成分比如免疫球蛋白等,尿毒症毒素也被滤过到“原尿”中,但其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等与血液相类似。 Application Method [0012] This particular embodiment is: its arterial end 4 is connected to the renal arteries, the blood of uremic patients through implantable bioartificial kidney according to "cleanse" the body 1 is connected via the renal vein and venous 5 reflux catheter body, the blood in the device at the blood pressure in vivo after filtration nanoscale silicon particles polyethylene glycol film 3, forming the "original urine", polyethylene glycol nanoscale silicon particles is similar to film 3 human glomerular filtration membrane, the molecular weight greater than 42,000 daltons play a good barrier effect, compared with the blood component in uremic patients, the "original urine" substantially free of macromolecular components such as immunoglobulins etc., uremic toxins is also filtered through the "original urine" but within its amino acid, glucose, small proteins, electrolytes and other blood components, and HC03 similar. “原尿”内的成分经过装置内的肾小管上皮细胞结构2重吸收,其内的氨基酸、葡萄糖、小分子蛋白、电解质成分和HC03等又被重新吸收入血,回流至体内。 Component in the "original urine" via tubular epithelial cells within the device structure reabsorption 2, in which the amino acid, glucose, small proteins, HC03 electrolyte components and the like has been re-absorbed into the bloodstream, is returned to the body. “原尿”中的剩余代谢产物、酸性成分等则随尿液流出通道6流至膀胱而排出体外。 The remaining metabolites "original urine" in the acidic components and the like with the passage 6 flows to the flow of urine excreted bladder. 人类肾小管上皮细胞有再生功能,可不断“补充”,而凋亡的肾小管上皮细胞本身和代谢产物则随本装置滤过后产生的“尿液”通过尿液流出通道6排出体外。 Human renal tubular epithelial cells regeneration can continue "complementary", and apoptosis of renal tubular epithelial cells with itself and metabolites are present after the filtration apparatus resulting "urine" excreted in the urine outflow passage 6.

[0013] 本具体实施方式具有以下有益效果:它结构简单,体积小,可植入到患者体内,方便了透析患者的治疗,扩宽了患者的活动范围。 [0013] DETAILED embodiment of the present embodiment has the following advantages: simple structure, small size, can be implanted in a patient, to facilitate the treatment of dialysis patients, broaden the range of activity of the patient.

Claims (1)

1.一种植入式生物人工肾装置,其特征在于它包含植入式生物人工肾本体(1)、肾小管上皮细胞层(2)、纳米级聚乙烯乙二醇硅颗粒膜(3)、动脉端(4)、静脉端(5)和尿液流出通道(6),植入式生物人工肾本体(1)的内部设置有纳米级聚乙烯乙二醇硅颗粒膜(3),纳米级聚乙烯乙二醇硅颗粒膜(3)的外侧设置有肾小管上皮细胞层(2),植入式生物人工肾本体(1)的一端与动脉端(4)连通,植入式生物人工肾本体(1)的另一端与静脉端(5)连接,且尿液流出通道¢)的一端与植入式生物人工肾本体(1)相连接。 1. An implantable bioartificial renal device, characterized in that it comprises an implantable bioartificial kidney body (1), renal tubular epithelial cell layer (2), the polyethylene glycol nanoscale silicon particles film (3), arterial end (4), venous (5) and urine outflow channel (6), an internal implantable bioartificial kidney body (1) is provided with a nanoscale silicon particles polyethylene glycol film (3), nanoscale polyethylene glycol outer film of silicon particles (3) is provided with a tubular epithelial cell layer (2), (4) communicating implantable bioartificial kidney body (1) and the end of the arterial end, the implantable bioartificial kidney the other end of the vein end of the body (1), (5), and the flow of urine passage ¢) one end implantable bioartificial kidney body (1) is connected.
CN 201410039297 2014-01-27 2014-01-27 An implantable bioartificial renal device CN103977465B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878564A (en) * 1972-04-14 1975-04-22 Shang J Yao Blood and tissue detoxification method
CN1469760A (en) * 2000-10-20 2004-01-21 约翰・M・莱温 Prosthesis for internal peritoneal dialysis
CN101505811A (en) * 2006-08-24 2009-08-12 弗雷泽纽斯医疗保健控股有限公司 Device for removing fluid from blood in a patient

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902336A (en) * 1996-10-15 1999-05-11 Mirimedical, Inc. Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878564A (en) * 1972-04-14 1975-04-22 Shang J Yao Blood and tissue detoxification method
CN1469760A (en) * 2000-10-20 2004-01-21 约翰・M・莱温 Prosthesis for internal peritoneal dialysis
CN101505811A (en) * 2006-08-24 2009-08-12 弗雷泽纽斯医疗保健控股有限公司 Device for removing fluid from blood in a patient

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