CN103977113A - 一种治疗糖尿病足的中药 - Google Patents
一种治疗糖尿病足的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗糖尿病足的中药，由下述重量份配比的原料制备而成：吴茱萸10-20份，艾叶10-20份，楤木10-20份，乌梅10-15份，生川乌10-15份，防风8-12份，红花5-10份、独活10-15份、羌活8-12份、当归尾5-10份、荆芥5-10份。将上述中药原料按比例称取，加生葱4条全株洗净切碎，米酒30份、米醋30份，加足量水煎煮。将药液煎成2000毫升，分两次，每次用1000毫升，药液不重复使用。本发明药剂具有辅助降糖、扩张血管、益气活血、化瘀通脉、解毒、防腐、敛疮生肌等功效。
Description
技术领域
本发明涉及糖尿病足治疗技术领域，具体涉及一种治疗糖尿病足的中药。
背景技术
糖尿病足是指糖尿病患者足部由于神经病变使下肢保护功能减退，大血管和微血管病变使动脉灌注不足致微循环障碍而发生溃疡和坏疽的疾病状态。糖尿病足是糖尿病一种严重的并发症，是糖尿病患者致残，甚至致死的重要原因之一，不但给患者造成痛苦，而且使其增添了巨大的经济负担。近年来，随着糖尿病发病率的提高，糖尿病足作为糖尿病的三大主要并发症之一，其发生率也随之增加。在非外伤截肢的患者中，50％以上为糖尿病足所致。
对于该病的病因，现代医学认为，糖尿病足是一种慢性进行性疾病，可波及大中小微血管，分为血管性和神经性两大类，可伴有感染，主要原因是肢端缺硒、神经病变、感染、代谢紊乱及多种诱因所致；中医认为该病主要为气阴两虚、淤血阻络，气血不能通达四肢所致。多由虚、淤、湿、毒所致，属于中医的“脱疽”、“筋疽”、“脉疽”的范畴，由于消渴病日久、阴血久伤或肝肾阴虚、复感邪毒、血热瘀阻经络肌肤溃烂为“疽”。
目前，对于糖尿病足的治疗均完全采取西医治疗方法，治疗效果有限，又无法根治该慢性进行性疾病。采用对症的中医药治疗可降低患者的血粘度，增加肢体血流量，解除微血管和局部组织的损害，使局部供血得到改善，有利于糖尿病足的康复。目前的一些治疗糖尿病足的药物，不能直达病灶，效果差，而且见效慢。
发明内容
本发明所要解决的技术问题是：提供一种治疗糖尿病足的中药，不但可以提高对糖尿病足的治疗效果，还可以达到根治该病的效果。
为解决上述技术问题，本发明的技术方案是：
一种治疗糖尿病足的中药，由下述重量份配比的原料制备而成：吴茱萸10-20份，艾叶10-20份，楤木10-20份，乌梅10-15份，生川乌10-15份，防风8-12份，红花5-10份、独活10-15份、羌活8-12份、当归尾5-10份、荆芥5-10份。
煎制方法：将上述中药原料按比例称取，加生葱4条全株洗净切碎，米酒30份、米醋30份，加足量水煎煮。将药液煎成2000毫升，分两次，每次用1000毫升，药液不重复使用。
使用方法：1.熏洗：糖尿病足初期(没有出现溃疡的时候使用，用来改善脚部供血不足)测药液温度40℃，浸洗患足及下肢20分钟。水温下降时，可随时加温，使药液保持温度。每天2次。根据病情需要，药汤可浸到踝关节或膝关节以上部位。
2.湿敷：适用于糖尿病足坏疽者(糖尿病足出现足溃疡)用消毒纱布7～8层或干净软布数层蘸药汤，趁热摊敷在患处，注意不要烫伤，另用一块消毒纱布不断地蘸药汤淋渍患处，持续淋渍20分钟。
本发明药剂具有辅助降糖、扩张血管、益气活血、化瘀通脉、解毒、防腐、敛疮生肌等功效。药剂中的各原料的药理为：
吴茱萸，辛、苦，热；有小毒。归肝、脾、胃、肾经。散寒止痛，降逆止呕，助阳止泻。用于厥阴头痛，寒疝腹痛，寒湿脚气，痛经，经行腹痛，脘腹胀痛，呕吐吞酸，五更泄泻，外治口疮；高血压。
艾叶，辛、苦，温；无毒。归肝、脾、肾经。散寒止痛，温经止血。用于少腹冷痛，经寒不调，宫冷不孕，吐血，衄血，崩漏经多，妊娠下血；外治皮肤瘙痒，脱皮。
楤木，甘、微苦，平。祛风除湿，利尿消肿，活血止痛。用于肝炎，淋巴结肿大，肾炎水肿，糖尿病，白带，胃痛，风湿关节痛，腰腿痛，跌打损伤。
乌梅，酸、涩，平。归肝、脾、肺、大肠经。敛肺，涩肠，生津，安蛔。用于肺虚久咳；虚热烦渴；久疟；久泻；痢疾；便血；尿血；血崩；蛔厥腹痛；呕吐；钩虫病。
川乌，辛、苦，热；有大毒。归心、肝、肾、脾经。祛风除湿，温经止痛。用于风寒湿痹、关节疼痛、心腹冷痛、寒疝作痛。用于治疗风寒湿痹、关节疼痛等病症。一般炮制后内服。生川乌酊外用能刺激皮肤，继而产生麻木感，故外用作某些神经痛及风湿的镇痛剂。
防风，性味：味辛；甘；性微温。归经：膀胱经；肺经；脾经；肝经。功效：祛风解表、胜湿止痛、解痉、止痒。主治：外感风寒；头痛身痛；风湿痹痛；骨节酸痛；腹痛泄泻；肠风下血；破伤风；风疹瘙痒；疮疡初起。
红花，性味：辛，温。归经：入心、肝经。活血通经，去瘀止痛。治经闭，症瘕，难产，死胎，产后恶露不行、瘀血作痛，痈肿，跌扑损伤。
独活，辛、苦，微温。归肝、肾、膀胱经。祛风胜湿；散寒止痛。用于风寒湿痹；腰膝疼痛；少阴伏风头痛，头痛齿痛。
羌活，味辛；苦；性温。散表寒；祛风湿；利关节；止痛。主外感风寒；头痛无汗；风水浮肿；疮疡肿毒。用于阳痿遗精，遗尿尿频，腰膝冷痛，肾虚作喘，五更泄泻；外用治白癜风，斑秃。解表散寒，祛风胜湿，止痛。
当归尾：活血祛瘀。应用：经闭不通及瘀血积滞肿痛的病症。
荆芥，味辛；微苦；性微温。入肺、肝经。功效主治祛风；解表；透疹；止血。主感冒发热；头痛；目痒；咳嗽；咽喉肿痛；麻疹；痈肿；疮疥；衄血；吐血；便血；崩漏；产后血晕。用于感冒，头痛，麻疹，风疹，疮疡初起。炒炭治便血，崩漏，产后血晕。解表散风，透疹，消疮，止血。用于感冒，麻疹透发不畅，便血、崩漏、鼻衄。
大葱，味辛，性微温，具有发表通阳、解毒调味的作用。主要用于风寒感冒、阴寒腹痛、恶寒发热、头痛鼻塞、乳汁不通，二便不利等。
米酒：能够帮助血液循环,促进新陈代谢,具有补血养颜,舒筋活络,强身健体和延年益寿的功效。对畏寒，血淤，缺奶，风湿性关节炎，腰酸背痛及手足麻木、神经衰弱等症有补益和疗效。
米醋：引药入肝，增强活血止痛作用；降低毒性，缓和药性；矫臭矫味；疏松药物，利于煎煮；增加药物有效成分的溶出；杀菌防腐。
本发明药剂具有辅助降糖、扩张血管、益气活血、化瘀通脉、解毒、防腐、敛疮生肌等功效，与胰岛素、抗生素等西药配合使用治疗有效率达92％以上。服药期间禁辛辣、酒等刺激性食物，保持精神舒畅。
本发明对糖尿病足的临床治疗效果详述如下：
1、病例选择
所选患者均符合糖尿病、糖尿病足(DF)诊断标准及wagner分级标准，两组患者均确诊为2型糖尿病、1-3级糖尿病足患者，随机分为观察组50例和对照组50例。两组患者的性别、年龄、病程、血糖比较，经统计学t检验，无显著性差异，具有可比性(见表一)。
表一：两组患者的一般情况
2、治疗方法
A组采用前列地尔10微克+0.9％生理盐水+血塞通0.5克静滴，并配以本发明中药药剂，每天一剂对患处进行药浴或湿敷。
B组采用前列地尔10微克+0.9％生理盐水+血塞通0.5克静滴。
3、实验结果对比
参照卫生部制定的《中药新药治疗急性疮疡临床研究指导原则》疗效标准。
临床治愈：临床症状消失，创面完全愈合；
显效：临床症状明显好转，创面2/3以上愈合；
有效：临床症状好转，创面1/2以上愈合；
无效：达不到有效标准者。
观察、记录两组患者足部溃疡面情况，临床结果如表二所示。
表二：两组患者临床疗效对比
4、实验结论
A组在常规治疗基础上选用本发明的药物进行药浴或湿敷，临床总有效率达94.0％，高于对照组的总有效率80.0％，疗效差异显著，说明本发明的药物可以有效治疗糖尿病足患者，疗效显著。
5、典型病例
(1)孙某，男，49岁，血糖高8年，间断服用口服降糖药、胰岛素，右足水疤、内有清水、破溃后感染，流脓性分泌物，局部疼痛，测血糖9mmol/L，餐后血糖15mmol/L，服用常规药物治疗,并用本发明药物进行湿敷，10天后，血糖正常，足部创面愈合。
(2)刘某，女，65岁，糖尿病史10年，治疗不系统，多自行购药，血糖未能达标多在10mmol/L以上，以往有高血压病6年，周足部处外伤摩擦后左足趾破溃，色黑流脓水，恶臭，化验血糖14.5mmol，糖化红蛋白11％,心电图显示部分ST-T改变，左下肢血管多普勒：动脉内斑块形成，服用常规药物治疗,并用本发明药物进行湿敷，一个疗程后，血糖正常，溃烂面明显减少，两个疗程后，血糖正常，创面愈合。
(3)王某，男，糖尿病足早期患者，感觉双脚皮肤瘙痒、怕冷、皮肤发白、肢端刺痛、麻木、感觉迟钝或丧失。走路时突然下肢疼痛难行，以后休息时也疼痛甚至彻夜难眠。用本发明药物足浴，3天后明显奏效，10天后，症状消失。
具体实施方式
实施例1.一种治疗糖尿病足的中药，由下述重量份配比的原料制备而成：吴茱萸10克，艾叶10克，楤木10克，乌梅10克，生川乌10克，防风8克，红花5克、独活10克、羌活8克、当归尾5克、荆芥5克。
煎制方法：将上述中药按重量比例称取，生葱4条全株洗净切碎，米酒30克、米醋30克，加足量水煎煮。将药液煎成2000毫升，分两次，每次用1000毫升，药液不重复使用。
使用方法：1.熏洗：糖尿病足初期(没有出现溃疡的时候使用，用来改善脚部供血不足)测药液温度40℃，浸洗患足及下肢20分钟。水温下降时，可随时加温，使药液保持温度。每天2次。根据病情需要，药汤可浸到踝关节或膝关节以上部位。
2.湿敷：适用于糖尿病足坏疽者(糖尿病足出现足溃疡)用消毒纱布7～8层或干净软布数层蘸药汤，趁热摊敷在患处，注意不要烫伤，另用一块消毒纱布不断地蘸药汤淋渍患处，持续淋渍20分钟。
实施例2.一种治疗糖尿病足的中药，由下述重量份配比的原料制备而成：吴茱萸20克，艾叶20克，楤木20克，乌梅15克，生川乌15克，防风12克，红花10克、独活15克、羌活12克、当归尾10克、荆芥10克。
制备和使用方法同实施例1。
实施例3.一种治疗糖尿病足的中药，由下述重量份配比的原料制备而成：吴茱萸15克，艾叶15克，楤木15克，乌梅12克，生川乌12克，防风10克，红花8克、独活12克、羌活10克、当归尾8克、荆芥8克。
制备和使用方法同实施例1。
实施例4.一种治疗糖尿病足的中药，由下述重量份配比的原料制备而成：吴茱萸18克，艾叶16克，楤木12克，乌梅13克，生川乌13克，防风9克，红花6克、独活11克、羌活9克、当归尾6克、荆芥7克。
制备和使用方法同实施例1。
Claims (4)
1.一种治疗糖尿病足的中药，其特征是，由下述重量份配比的原料制备而成：吴茱萸10-20份，艾叶10-20份，楤木10-20份，乌梅10-15份，生川乌10-15份，防风8-12份，红花5-10份、独活10-15份、羌活8-12份、当归尾5-10份、荆芥5-10份。
2.如权利要求1所述的一种治疗糖尿病足的中药，其特征是，由下述重量份配比的原料制备而成：吴茱萸15份，艾叶15份，楤木15份，乌梅12份，生川乌12份，防风10份，红花8份、独活12份、羌活10份、当归尾8份、荆芥8份。
3.如权利要求1所述的一种治疗糖尿病足的中药，其特征是，由下述重量份配比的原料制备而成：吴茱萸18份，艾叶16份，楤木12份，乌梅13份，生川乌13份，防风9份，红花6份、独活11份、羌活9份、当归尾6份、荆芥7份。
4.一种权利要求1所述的治疗糖尿病足的中药的制备方法，其特征是，包括以下步骤：将权利要求1所述中药原料按比例称取，加生葱4条全株洗净切碎，米酒30份、米醋30份，加足量水煎煮即可。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105288308A (zh) * | 2015-12-01 | 2016-02-03 | 卢广民 | 一种治疗糖尿病足的中药制剂及其制备方法 |
| CN106215014A (zh) * | 2016-08-30 | 2016-12-14 | 贵州百灵企业集团制药股份有限公司 | 一种用于治疗糖尿病足的外用中药复方制剂及其制备方法 |
| CN114272295A (zh) * | 2020-09-27 | 2022-04-05 | 鲁南制药集团股份有限公司 | 一种治疗糖尿病肢端坏疽的中药组合物 |
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| 王建春等: "渴疽洗方足浴治疗糖尿病足筋疽型60例疗效观察", 《广州中医药大学学报》, vol. 26, no. 4, 31 July 2009 (2009-07-31), pages 343 - 346 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288308A (zh) * | 2015-12-01 | 2016-02-03 | 卢广民 | 一种治疗糖尿病足的中药制剂及其制备方法 |
| CN106215014A (zh) * | 2016-08-30 | 2016-12-14 | 贵州百灵企业集团制药股份有限公司 | 一种用于治疗糖尿病足的外用中药复方制剂及其制备方法 |
| CN114272295A (zh) * | 2020-09-27 | 2022-04-05 | 鲁南制药集团股份有限公司 | 一种治疗糖尿病肢端坏疽的中药组合物 |
| CN114272295B (zh) * | 2020-09-27 | 2023-11-24 | 鲁南制药集团股份有限公司 | 一种治疗糖尿病肢端坏疽的中药组合物 |
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