CN103919991A - Traditional Chinese medicine for preventing and treating hyperglycemia - Google Patents

Abstract

The invention provides a traditional Chinese medicine for preventing and treating hyperglycemia. The traditional Chinese medicine for preventing and treating hyperglycemia comprises the following raw materials in parts by weight: 10-20 parts of lycopodium clavatum, 8-20 parts of plumeria rubra, 3-10 parts of liquorice, 5-10 parts of semen cuscutae, 10-20 parts of poria cocos and 5-10 parts of dwarf lilyturf root. The traditional Chinese medicine has the advantages that the plumeria rubra, the semen cuscutae, the poria cocos, the dwarf lilyturf root and juncus effuses are used for conditioning the balance of the heart, the liver, the spleen, the lung and the kidney of a human body, dispersing blood stasis, eliminating turbidity and quenching thirst, the lycopodium clavatum is used for relaxing the muscles, simulating the blood circulation, reinforcing qi and dredging collaterals, so that the purpose of reducing blood sugar level is achieved, and the traditional Chinese medicine is suitable for patients with hyperglycemia, diabetes and the like.

Description

Prevent and treat the Chinese medicine of hyperglycemia

Technical field

The present invention relates to a kind of Chinese medicine of preventing and treating hyperglycemia, especially a kind of adapted Herba Lycopodii is prevented and treated the Chinese medicine of hyperglycemia, diabetes.

Background technology

Hyperglycemia refer to when on an empty stomach in 8 hours sugar-free and any sugary food intake blood glucose higher than normal range (4.0-6.1mmol/L) or after the meal two hours blood glucoses higher than 7.8mmol/L normal range.

Diabetes are to act on that body causes hypoinsulinism, insulin resistant etc. and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors etc. various virulence factors.Take hyperglycemia clinically as main feature, the performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. " three-many-one-little " symptom, diabetes (blood glucose) cause complication once control bad meeting, the exhaustion pathological changes that causes the positions such as kidney, eye, foot, general medicine is difficult to radical cure, takes merely Western medicine blood sugar lowering or insulin injection and also can only temporarily control, and life-time service can cause occurring a series of complication.Therefore, Western medicine blood sugar lowering has weak point.

Summary of the invention

In order to solve the deficiencies in the prior art, the object of the invention is to provide a kind of Chinese medicine of preventing and treating hyperglycemia.

Technical scheme: a kind of Chinese medicine of preventing and treating hyperglycemia, is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10-20, Flos Plumeriae Acutifoliae 8-20, Radix Glycyrrhizae 3-10, Semen Cuscutae 5-10, Poria 10-20, Radix Ophiopogonis 5-10.

As optimization, a kind of Chinese medicine of preventing and treating hyperglycemia of the present invention, is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10, Flos Plumeriae Acutifoliae 10, Radix Glycyrrhizae 3, Semen Cuscutae 5, Poria 10, Radix Ophiopogonis 5.

As optimization, a kind of Chinese medicine of preventing and treating hyperglycemia of the present invention, is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10-20, Flos Plumeriae Acutifoliae 8-20, Radix Glycyrrhizae 3-10, Semen Cuscutae 5-10, Poria 10-20, Radix Ophiopogonis 5-10, Medulla Junci 3-5, Fructus Mume 3-10.

Herba Lycopodii, toil temperature, expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons and activating QI and blood in the collateral.< < Hunan medicine will > > records Herba Lycopodii: sweet, flat.Nontoxic, enter the heart, kidney two warps, relaxing muscles and tendons to promote blood circulation, invigorating qi and dredging collateral.

Flos Plumeriae Acutifoliae, cool in nature, sweet in the mouth, light; Return large intestine, stomach warp, there is the effect of lung moistening removing toxic substances, clearing heat and expelling damp, laxation.

Radix Glycyrrhizae sweet in the mouth is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Semen Cuscutae acrid-sweet flavor, property is flat, enters liver, kidney two warps.There is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive effect.

Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.

Radix Ophiopogonis, the micro-sugariness of property is bitter, cold, has nourishing YIN and moistening the lung, reinforcing stomach reg fluid, a relieving restlessness that clears away heart-fire, reinforcing YIN-essence benefit essence, settling five organs effect.

Medulla Junci, is slightly cold; Sweet, light; GUIXIN; Lung; Small intestinal; Urinary bladder channel.Effect: relieving stranguria by diuresis; Clearing heart fire.Fructus Mume is sour, puckery, flat, returns liver, spleen, lung, large intestine channel.[function cures mainly] astringes the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract (< < Chinese Pharmacopoeia > >).

The traditional Chinese medical science thinks, diabetes are mainly that the five internal organs are weak due to the plain body deficiency of YIN, multiple because of eating and drinking without temperance, surfeit delicious food, and disorder of emotion, labor is wanted excessively, and causes deficiency of kidney-YIN, lung dryness of the stomach heat; Pathogenesis emphasis is that the deficiency of YIN is scorching, and take the deficiency of YIN as this, and scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and the bright liquid in consumption Tianjin makes blood viscous, the not smooth stasis of blood that forms of blood; Deficiency of YIN affecting YANG, yang deficiency cold coagulation, also can cause sun in blood stasis.

Advantage of the present invention: 1, Herba Lycopodii Xin Wenyi impairment of YIN blood of the present invention, therefore adapted Flos Plumeriae Acutifoliae, Radix Glycyrrhizae are in harmonious proportion, make its institute partially, its taste is glycol, fresh and sweet, has channels sootheing and network vessel quickening, function of promoting blood circulation to disperse blood clots.

2, Semen Cuscutae the kidney invigorating and essence nourishing, Poria promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, Radix Ophiopogonis nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, Medulla Junci clearing heart fire, Fructus Mume are quenched one's thirst and are brought down a fever, and more contribute to blood circulation promoting and blood stasis dispelling blood sugar lowering.

3, the present invention is by the balance of Flos Plumeriae Acutifoliae, Semen Cuscutae, Poria, Radix Ophiopogonis, Medulla Junci conditioning human body-centered liver spleen lung kidney the five internal organs, blood stasis dispelling is pure and impure quenches one's thirst, use again Herba Lycopodii relaxing muscles and tendons to promote blood circulation, thereby invigorating qi and dredging collateral reaches hypoglycemic object, be applicable to the patients such as hyperglycemia, diabetes.

4, the present invention has significant hypoglycemic activity to epinephrine hyperglycemia mice and alloxan hyperglycemia mice.Each 20 of male and female mices are selected in experiment; Adopt respectively epinephrine and alloxan to set up hyperglycemia mouse model, then give Chinese medicine powder of the present invention, glibenclamide, phenformin is treated and survey blood sugar level.In the hyperglycemia mice of bringing out at epinephrine, the present invention can make fasting serum glucose [(16. 58 ± 3. 92) mmol/L] be reduced to (7. 56 ± 2. 63) mmol/L, effect and glibenclamide comparison, no significant difference (P>0.05); In the hyperglycemia mice of model induced by alloxan, the present invention is reduced to fasting serum glucose [(15. 56 ± 1. 83) mmol/L] (7. 55 ± 1.65) mmol/L, blood sugar reducing function is significantly better than phenformin (P<0 05), and causes hypoglycemic side effect without glibenclamide.Conclusion: the present invention can significantly reduce the blood sugar level (P <0. 001) of 2 kinds of modeling animals, and makes blood glucose be down to normal level.

5, the present invention shows through more than the 60 routine sugared dung patients' that make a definite diagnosis clinical observation on the therapeutic effect, and the present invention has remarkable reduction glycosuria patient's blood sugar level, makes blood sugar recovery normal.

the specific embodiment

Embodiment 1: a kind of Chinese medicine of preventing and treating hyperglycemia, is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10-20, Flos Plumeriae Acutifoliae 8-20, Radix Glycyrrhizae 3-10, Semen Cuscutae 5-10, Poria 10-20, Radix Ophiopogonis 5-10.

Instructions of taking: above medical material routinely preparation process is made Chinese medicine powder or capsule, every natural gift are taken for three times, each 4-8 gram.

Embodiment 2: a kind of Chinese medicine of preventing and treating hyperglycemia, is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10, Flos Plumeriae Acutifoliae 10, Radix Glycyrrhizae 3, Semen Cuscutae 5, Poria 10, Radix Ophiopogonis 5.

Instructions of taking is with embodiment 1.

Embodiment 3: a kind of Chinese medicine of preventing and treating hyperglycemia, is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10-20, Flos Plumeriae Acutifoliae 8-20, Radix Glycyrrhizae 3-10, Semen Cuscutae 5-10, Poria 10-20, Radix Ophiopogonis 5-10, Medulla Junci 3-5, Fructus Mume 3-10.

Instructions of taking is with embodiment 1.

Clinical observation result of the present invention:

1.1 physical data: select the People's Hospital, city outpatient service type 2 diabetes mellitus patient 60 examples, be divided at random two groups.Treatment group 30 examples, male 16 examples, female's 14 examples, 30～70 years old age, average (50 ± 1.5) year, the course of disease 6 months～15 years, average (8.0 ± 1.2) year; Matched group 30 examples, male 18 examples, female's 12 examples, 29～70 years old age.Two groups of physical data comparing difference not statistically significants (P>0.05), have comparability.

1.2 case selections: with reference to World Health Organization's (WHO) diabetes diagnosis in 1999 and typing standard [1]: diabetic symptom+random time plasma glucose levels >=11.1mmol/L(200mg/dl).The patient's random packet that meets above-mentioned standard is carried out to observational study, and the patient that part takes traditional Chinese medicine stops former Chinese medicine and includes observation in after 2 weeks, and the patient's to be directly brought into not taking traditional Chinese medicine is observed.Two groups of patients all give diabetes Primary Care, comprise diet control, exercise therapy and orally-taken blood sugar reducing Western medicine, and blood sugar lowering Western medicine adopts metformin, according to blood glucose situation, carries out drug usage and dose adjustment.

1.3 Therapeutic Method: treatment group is taken Chinese medicine powder of the present invention taking on the basis of metformin.Basic side is comprised of the composition of raw materials of following weight portion: Herba Lycopodii 10, Flos Plumeriae Acutifoliae 10, Radix Glycyrrhizae 3, Semen Cuscutae 5, Poria 10, Radix Ophiopogonis 5; Every natural gift are taken for three times, each 4 grams.Matched group routine is taken metformin.Two groups are consistent in diet control, exercise therapy, and be 2 months two groups of courses for the treatment of.

1.4 observation index: measure respectively fasting glucose (FPG), post-prandial glycemia (2hBG), glycolated hemoglobin (HbA1c), fasting insulin (FINS), blood fat (TC, TG, HDL-C, LDL-C) before and after treatment, blood glucose determination of glucose oxidase, insulin is measured with putting the method for exempting from, blood fat is measured with automatic clinical chemistry analyzer, HOMA-IR employing Haffner etc. [3,4] in Homa model, calculate the formula of IR, be HOMA-IR=FPG * FINS/22.5 (FPG unit is mmol/L, and FINS unit is mU/L).

1.5 statistical methods: adopt SPSS 14.0 statistical analysis softwares to carry out statistical procedures.Measurement data adopts t check, enumeration data chi-square criterion.

2 results: before and after two groups of treatments, the variation of FPG, 2hBG, HbAIc, FINS and HOMA-IR refers to table 1.By in table 1, we can see, treat front two groups of patient FPG, 2hBG, HbAlc, FINS, the horizontal comparing difference not statistically significant of HOMA-IR (P>0.05); After treating, two groups of FPG, 2hBG, HbAlc, FINS, HOMA-IR levels have statistical significance (P<0.05 or P<0.01) with the front comparing differences for the treatment of, before treatment group patient's These parameters and treatment, relatively have significant difference (P<0.01).Prompting treatment group and matched group all can reduce diabetes blood glucose, but it is more obvious with treatment group, to improve blood glucose.

The variation of FPG, 2hBG, HbAlc, FINS and HOMA-IR before and after table 1 liang group patient treatment

Note: indices is compared with before treatment: * P<0.05, * * P<0.01; The rear two groups of FINS for the treatment of and HOMA-IR compare ^P<0.05, ^^P<0.01.

Before and after two groups of patient treatments, the variation of TC, TG, HDL-C, LDL-C is in Table 2.From table 2, we can see the front two groups of patients' for the treatment of the horizontal comparing difference not statistically significant of TC, TG, HDL-C, LDL-C (P>0.05); After treatment, TC, TG, HDL-C, the LDL-C level of two groups have significant change, wherein TC, TG, LDL-C level have statistical significance (P<0.05) with the front comparing difference for the treatment of, and relatively have significant difference (P<0.01) before treatment group HDL-C level and treatment.Illustrate that treatment group and matched group all can improve the blood lipid level of diabetics, and more remarkable with treatment group effect.

The variation of TC, TG, HDL-C, the horizontal content of LDL-C before and after table 2 liang group patient treatment

Note: indices is compared with before treatment: * P<0.05, * * P<0.01; After treatment, two groups of indices are compared ^P<0.05, ^^P<0.01.

Claims (3)

1. prevent and treat a Chinese medicine for hyperglycemia, it is characterized in that being formed by the composition of raw materials of following weight portion: Herba Lycopodii 10-20, Flos Plumeriae Acutifoliae 8-20, Radix Glycyrrhizae 3-10, Semen Cuscutae 5-10, Poria 10-20, Radix Ophiopogonis 5-10.

2. the Chinese medicine of preventing and treating hyperglycemia according to claim 1, is characterized in that: Herba Lycopodii 10, Flos Plumeriae Acutifoliae 10, Radix Glycyrrhizae 3, Semen Cuscutae 5, Poria 10, Radix Ophiopogonis 5.

3. prevent and treat a Chinese medicine for hyperglycemia, it is characterized in that being formed by the composition of raw materials of following weight portion: Herba Lycopodii 10-20, Flos Plumeriae Acutifoliae 8-20, Radix Glycyrrhizae 3-10, Semen Cuscutae 5-10, Poria 10-20, Radix Ophiopogonis 5-10, Medulla Junci 3-5, Fructus Mume 3-10.

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