CN103919964B - One kind has promoting blood circulation, antalgic, the Chinese veterinary medicinal composition of lactagogue function and its production and use - Google Patents

One kind has promoting blood circulation, antalgic, the Chinese veterinary medicinal composition of lactagogue function and its production and use Download PDF

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Publication number
CN103919964B
CN103919964B CN201410160727.6A CN201410160727A CN103919964B CN 103919964 B CN103919964 B CN 103919964B CN 201410160727 A CN201410160727 A CN 201410160727A CN 103919964 B CN103919964 B CN 103919964B
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chinese
parts
powder
bacterium powder
medicinal composition
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CN103919964A (en
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丁晓刚
王万平
杨森
房春林
李犹平
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SHANGHAI SIMENON BIOTECH Co Ltd
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SHANGHAI SIMENON BIOTECH Co Ltd
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Abstract

The invention provides one kind to have promoting blood circulation, antalgic, and the Chinese veterinary medicinal composition of lactagogue function, it is prepared by the bulk drug of following weight proportioning:2,000 3000 parts of acalypha copperleaf, 2,000 3000 parts of rhizoma atractylodis, 2,000 3000 parts of rhizoma alismatis, 500 2000 parts of Chinese yam, 500 2000 parts of the root of herbaceous peony, 1.5 4.5 parts of rhizopus chinensis bacterium powder, 1.5 4.5 parts of Chinese head mold bacterium powder.Present invention also offers the preparation method of the Chinese veterinary medicinal composition and purposes.Herbal medicine of the present invention not only has the scattered basic function of former female young peace, also with promoting blood circulation, antalgic, lactagogue function;Its palatability is also very significantly improved simultaneously.

Description

One kind have promoting blood circulation, antalgic, the Chinese veterinary medicinal composition of lactagogue function and its Preparation method and purposes
Technical field
The present invention relates to one kind to have promoting blood circulation, antalgic, the Chinese veterinary medicinal composition of lactagogue function.
Background technology
Female young peace, which dissipates, is《Veterinary drug national standard collects》Second herbal medicine prescription included, by acalypha copperleaf, rhizoma atractylodis, pool Rush down, Chinese yam, the root of herbaceous peony traditional Chinese medicine of the five flavours composition, have strengthening the spleen and replenishing qi, dampness-eliminating and dysentery-stopping function.By preventing piglet Huang to sow medication Dysentery, dysentery characterized by white mucous stool.Rhizoma atractylodis are drying damp and strengthening spleen in side, expelling wind and clearing away cold, are monarch drug in a prescription;Acalypha copperleaf is clearing heat and detoxicating, dampness removing, astringing to arrest bleeding, rhizoma alismatis profit Water excreting dampness, it is altogether ministerial drug;Chinese yam tonifying spleen, root of herbaceous peony blood-nourishing hold back cloudy, emergency and in, be altogether adjutant.All medicines share, invigorating the spleen benefit is played altogether The work(of gas, dampness-eliminating and dysentery-stopping.Modern pharmacology and toxicologic study show that rhizoma atractylodis have antibacterial, digestion promoting function in side;Rhizoma alismatis have liver protection and Diuresis;Chinese yam has aid digestion, convergence and enhancing immunization;The root of herbaceous peony has antibacterial, spasmolysis and liver protection and detoxication.Face During bed application, in order to promote the sow after production to exclude lochia, prevent postpartum infection, stimulate the secretion of milk, generally require spice and feed it He treats at medicine in itself to sow, if now along with the female young peaces of 50g dissipate, with respect to feed intake of sow postpartum Speech, the dose admixed is too big, changes the palatability of feed, sow food refusal, can be allowed even with flavourings such as addition white sugar Sow is eaten, and that also greatly adds cost;Meanwhile it the medicine of different purposes be used in mixed way may also cause between medicine Interfering makes drug effect change, and adds the uncertainty of curative effect.In order to overcome problem above, it is necessary to which female young peace is dissipated Function is extended and improves its palatability.
The content of the invention
The technical scheme is that provide a kind of with promoting blood circulation, antalgic, the herbal medicine group of lactagogue function Compound.Another technical scheme of the present invention there is provided the preparation method and purposes of the Chinese veterinary medicinal composition.
The invention provides one kind to have promoting blood circulation, antalgic, and the Chinese veterinary medicinal composition of lactagogue function, it is under The bulk drug for stating weight proportion is prepared:
Acalypha copperleaf 2000-3000 parts, rhizoma atractylodis 2000-3000 parts, rhizoma alismatis 2000-3000 parts, Chinese yam 500-2000 parts, the root of herbaceous peony 500-2000 parts, rhizopus chinensis bacterium powder 1.5-4.5 parts, Chinese head mold bacterium powder 1.5-4.5 parts.
It is further preferred that it is prepared by the bulk drug of following weight proportioning:
2000 parts of acalypha copperleaf, 3000 parts of rhizoma atractylodis, 3000 parts of rhizoma alismatis, 1500 parts of Chinese yam, root of herbaceous peony 500-2000 parts, rhizopus chinensis 3 parts of bacterium powder, 3 parts of Chinese head mold bacterium powder;
Or
2500 parts of acalypha copperleaf, 2500 parts of rhizoma atractylodis, 2500 parts of rhizoma alismatis, 1500 parts of Chinese yam, 1000 parts of the root of herbaceous peony, rhizopus chinensis bacterium powder 3 Part, 3 parts of Chinese head mold bacterium powder;
Or
3000 parts of acalypha copperleaf, 2000 parts of rhizoma atractylodis, 2000 parts of rhizoma alismatis, 1500 parts of Chinese yam, 1500 parts of the root of herbaceous peony, rhizopus chinensis bacterium powder 3 Part, 3 parts of Chinese head mold bacterium powder;
Wherein, the preparation technology of described rhizopus chinensis bacterium powder and Chinese head mold bacterium powder comprises the following steps:
A, ground rice culture medium is prepared:
Take long-grained nonglutinous rice to crush, cross 60 mesh sieves, add water, stir, after crossing 20 mesh sieves, be sub-packed in 500ml triangular flasks, every bottle 80g, sealed with tampon, and wrapped up with oilpaper, 0.1MPa high pressure sterilizations 30 minutes;
B, aseptically, by invisible spectro rhizopus chinensis inclined-plane opportunistic pathogen, wherein culture presevation number 40512, purchased from China Research for Industrial Microbial Germ preservation administrative center and middle rhizopus chinensis inclined-plane opportunistic pathogen, culture presevation number 41410, purchased from the micro- life of Chinese industrial Thing culture presevation administrative center, takes out together with culture medium, smashs to pieces, is inoculated into triangular flask ground rice culture medium respectively and stirs equal Even, every plant of inclined-plane opportunistic pathogen is inoculated with 3~4 triangular flask ground rice culture mediums;
C, triangular flask is sealed with ventilated membrane, in 28 DEG C~32 DEG C, cultivate 48~72 hours, produce rhizopus chinensis bacterium powder with Chinese head mold bacterium powder.
Chinese veterinary medicinal composition of the present invention is by adding rhizopus chinensis in acalypha copperleaf, rhizoma atractylodis, rhizoma alismatis, Chinese yam, root of herbaceous peony material powder Bacterium powder after fermentation, adds the oral system that pharmaceutically conventional auxiliary material or complementary composition are prepared with Chinese head mold bacterium powder Agent.
Wherein, described oral formulations are powder.
Present invention also offers a kind of method for preparing described Chinese veterinary medicinal composition, it comprises the following steps:
A, the raw material of each weight proportion is weighed;
B, Chinese yam is taken, adds water, is cooked, rubs broken, iron amaranth vegetable powder, rhizopus chinensis bacterium powder and Chinese head mold bacterium powder is admixed, mixes thoroughly, it is close Close, 28 DEG C~35 DEG C fermentation 3~7 days after be well mixed with rhizoma alismatis powder, herbaceous peony powder, rhizoma atractylodis powder, dry, produce.
Present invention also offers the Chinese veterinary medicinal composition to prepare with promoting blood circulation, antalgic, the beast of lactagogue function Purposes in medicine.
Herbal medicine of the present invention not only has the scattered basic function of former female young peace, also with promoting blood circulation, antalgic, lactagogue Function;Its palatability is also very significantly improved simultaneously.
Embodiment
Chinese veterinary medicinal composition of the present invention, hereinafter referred to as " saccharification mother and sons' peace dissipates ".
Embodiment 1 is scattered with fresh yam fermentation saccharification preparation saccharification mother and sons' peace
First, the preparation of rhizopus chinensis bacterium powder and Chinese head mold bacterium powder
Take long-grained nonglutinous rice 500g to crush, cross 60 mesh sieves, add 125~130ml of water, stir, after crossing 20 mesh sieves, be sub-packed in In 500ml triangular flasks, every bottle of about 80g, sealed with tampon, and wrapped up with oilpaper, 0.1MPa high pressure sterilizations 30 minutes.In sterile bar Under part, by invisible spectro rhizopus chinensis inclined-plane opportunistic pathogen(Culture presevation number 40512, purchased from Chinese industrial Microbiological Culture Collection management Center)With middle rhizopus chinensis inclined-plane opportunistic pathogen(Culture presevation number 41410, purchased from Chinese industrial Microbiological Culture Collection administrative center)Even Take out, smash to pieces together with culture medium, be inoculated into triangular flask ground rice culture medium respectively and stir(Every plant of inclined-plane opportunistic pathogen inoculation 3 ~4 triangular flask ground rice culture mediums), triangular flask is sealed with ventilated membrane, in 28 DEG C~32 DEG C, cultivated 48~72 hours.See Examine, ground rice molding in triangular flask, surface is covered with white hypha, and without the miscellaneous bacteria of the spots such as yellow, produces.
2nd, remove skin fresh yam 5kg (equivalent to Chinese yam medicine materical crude slice 1kg), cut into slices, cook, dry in the air cool to human body temperature, rub it is broken, Admix iron amaranth vegetable powder(It is saturating with sterilizing water-soaked after hot air sterilization)2kg, rhizopus chinensis bacterium powder and Chinese each 3g of head mold bacterium powder, it is closed, 28 DEG C~35 DEG C fermentation 3~7 days after be well mixed with rhizoma alismatis powder 2kg, herbaceous peony powder 1kg, rhizoma atractylodis powder 2kg, dry, produce.
Embodiment 2 prepares saccharification mother and sons' peace with the fermentation saccharification of Chinese yam medicine materical crude slice and dissipated
Chinese yam medicine materical crude slice 1kg is taken, adds water saturates, cooks, is dried in the air cool to human body temperature, rubs broken, admixes iron amaranth vegetable powder(Hot air sterilization It is saturating with sterilizing water-soaked afterwards)2kg, rhizopus chinensis bacterium powder and Chinese each 3g of head mold bacterium powder, it is closed, after 28 DEG C~35 DEG C ferment 3~7 It is well mixed with rhizoma alismatis powder 2kg, herbaceous peony powder 1kg, rhizoma atractylodis powder 2kg, dries, produce.
Embodiment 3 is saccharified, and mother is young to pacify scattered recipe determination
What Chinese medicine did not passed secret is dosage.An important factor for species, dosage and the combination of medicinal material are prescriptions, they are straight Connect the effect of being related to the prescription.For the present invention " the female young peace of saccharification dissipates ", because of indivedual fermented saccharification processing of medicine therein Afterwards, pharmic function is changed, and therefore, dosage can also change.The present invention is with piglet Huang, the dysentery characterized by white mucous stool incidence of disease (Morbidity of Early colibacillosis and Delayed colibacillosis in Piglets, MCP), the inflammation incidence of disease of sow postpartum three(Morbidity of Three Inflammation in Postpartum Sows, MTI), the average daily milk yield of sow(Average Daily Yielding of Sows, ADY)With feeding situation(Feed Situation, FS)For index, investigate female young peace and dissipate yellow to piglet, dysentery characterized by white mucous stool preventing and treating function, and the prescription after fermentation saccharification The inflammation preventing and treating function of sow postpartum three, lactagogue function and the palatability newly increased, formula is screened.
(One)The preparation of different formulations product
Take and defined supplementary material under item is respectively formulated in table 1, preparing female young pacify of saccharification according to the method for embodiment 2 dissipates.
The preferred scheme of the female young peace powder formula of the present invention saccharification of table 1
Prescription number Acalypha copperleaf Rhizoma atractylodis Rhizoma alismatis Chinese yam The root of herbaceous peony
1 2.0 3.0 2.0 2.0 1.0
2 2.0 3.0 3.0 1.5 0.5
3 2.5 2.5 2.5 1.5 1.0
4 2.5 2.5 2.5 0.5 2.0
5 3.0 2.0 2.0 1.5 1.5
6 3.0 2.0 3.0 0.5 1.5
7 1.9 2.5 3.1 2.1 0.4
8 3.1 1.9 2.5 0.4 2.1
9 2.5 3.1 1.9 2.1 0.4
(Two)The quality evaluation of different formulations product
The preventing and treating functional evaluation of piglet yellow-white dysentery:The female young peace of the saccharification prepared by table 1 is taken to dissipate, it is female to feed farrowing by spice Pig, every sow once feed 50g, 2 times a day, from the same day of farrowing, even served 3.Observe and record piglet Huang, the morbidity of dysentery characterized by white mucous stool Rate(MCP).
The inflammation of sow postpartum three prevents and treats functional evaluation:Take the female young peace of the saccharification prepared by table 1 to dissipate, fed and farrowed by spice Sow, every sow once feed 50g, 2 times a day, from the same day of farrowing, even served 3.Observe and record the inflammation of sow postpartum three The incidence of disease(MTI).
Lactagogue functional evaluation:Take the female young peace of the saccharification prepared by table 1 to dissipate, farrowing sow, every sow are fed by spice 50g is once fed, 2 times a day, from the same day of farrowing, even served 3.And whole nest piglet original body mass and 7 age in days body weight are weighed, calculate Average daily gain;Sow is calculated according to the relation of average daily milk yield=whole nest piglet average daily gain × 4 of sow averagely to produce daily Breast amount(ADY).
Palatability evaluation:Take the female young peace of the saccharification prepared by table 1 to dissipate, farrowing sow is fed by spice, mixed per 1kg feeds Enter 50g medicines.Observe sow feeding situation(FS), disposably quickly feeding is chosen as " excellent " completely;Just eat up and be chosen as through repeatedly feeding " good ";Do not eat up still and be chosen as " poor " to second of feeding time.
The female young peace of the present invention saccharification of table 2 dissipates quality evaluation result
Carrying out comprehensive analysis to 4 indexs listed by table 2 can obtain:Formula 1~6 is qualified, wherein again with formula 2,3,5 for most It is excellent.
Beneficial effects of the present invention are illustrated below by way of test example.
Test example 1 is saccharified, and mother is young to pacify scattered clinical effectiveness investigation
Material:Female young peace dissipates(Shanghai Ximonong Bio-Tech Co., Ltd., press《Veterinary drug national standard collects》Regulation life Production);The female young peace of saccharification dissipates(It is prepared by embodiment 2).
Experimental animal:Farrow sow 30 on Xiuqian City of Jiangsu Province pig farm.
Method:Farrowing sow is divided into control group, test group and negative control group at random under identical rearing conditions, every group 10;Control group is dissipated with the female young peace of mark rule to be fed by each 50g/ heads spice, 2 times a day, is used in conjunction 3 days;Test group embodiment 2 The female young peace of the saccharification of preparation dissipates to be fed by each 50g/ heads spice, 2 times a day, is used in conjunction 3 days;Negative control group presses daily raising side Formula is raised, and is not administered.The feeding situation of sow is observed while medication(FS), and evaluated by above-mentioned evaluation method;Observation Record piglet Huang, the incidence of disease of dysentery characterized by white mucous stool(MCP);Observe and record the inflammation incidence of disease of sow postpartum three(MTI);At the beginning of weighing whole nest piglet Initial body weight and 7 age in days body weight, calculate the average daily milk yield of sow(ADY).It the results are shown in Table 3.
Table 3 is saccharified, and female young peace is scattered to investigate result
As can be seen from the above test results, the female young scattered clinical effectiveness of peace of saccharification of the invention is superior to female young pacify of mark rule and dissipated.

Claims (6)

1. a kind of have raising sow grazing rate, the average daily milk yield of increase sow, reduce the inflammation incidence of disease of sow postpartum three Chinese veterinary medicinal composition, it is characterised in that:It is prepared by the bulk drug of following weight proportioning:
2000 parts of acalypha copperleaf, 2000 parts of rhizoma atractylodis, 2000 parts of rhizoma alismatis, 1000 parts of Chinese yam, 1000 parts of the root of herbaceous peony, 3 parts of rhizopus chinensis bacterium powder, in 3 parts of rhizopus chinensis bacterium powder.
2. Chinese veterinary medicinal composition according to claim 1, it is characterised in that:Described rhizopus chinensis bacterium powder and Chinese rhizopus The preparation technology of powder comprises the following steps:
A, ground rice culture medium is prepared:
Take long-grained nonglutinous rice to crush, cross 60 mesh sieves, add water, stir, after crossing 20 mesh sieves, be sub-packed in 500ml triangular flasks, every bottle of 80g, Sealed with tampon, and wrapped up with oilpaper, 0.1MPa high pressure sterilizations 30 minutes;
B, aseptically, by invisible spectro rhizopus chinensis inclined-plane opportunistic pathogen, wherein culture presevation number 40512, purchased from Chinese industrial Microbiological Culture Collection administrative center and middle rhizopus chinensis inclined-plane opportunistic pathogen, culture presevation number 41410, purchased from Chinese industrial microbial bacteria Kind preservation administrative center, takes out together with culture medium, smashs to pieces, be inoculated into triangular flask ground rice culture medium respectively and stir, Every plant of inclined-plane opportunistic pathogen is inoculated with 3~4 triangular flask ground rice culture mediums;
C, triangular flask is sealed with ventilated membrane, in 28 DEG C~32 DEG C, cultivates 48~72 hours, produce rhizopus chinensis bacterium powder and China Head mold bacterium powder.
3. Chinese veterinary medicinal composition according to claim 1, it is characterised in that:It is by acalypha copperleaf, rhizoma atractylodis, rhizoma alismatis, Chinese yam, Rhizopus chinensis bacterium powder is added in root of herbaceous peony material powder with Chinese head mold bacterium powder after fermentation, the auxiliary material or auxiliary that addition is pharmaceutically commonly used The oral formulations that helping property composition is prepared.
4. Chinese veterinary medicinal composition according to claim 3, it is characterised in that:Described oral formulations are powder.
5. a kind of method for preparing the Chinese veterinary medicinal composition described in claim 1-4 any one, it comprises the following steps:
A, the raw material of each weight proportion is weighed;
B, Chinese yam is taken, adds water, is cooked, rubs broken, iron amaranth vegetable powder, rhizopus chinensis bacterium powder and Chinese head mold bacterium powder is admixed, mixes thoroughly, it is closed, 28 DEG C~35 DEG C fermentation 3~7 days after be well mixed with rhizoma alismatis powder, herbaceous peony powder, rhizoma atractylodis powder, dry, produce.
6. the Chinese veterinary medicinal composition described in claim 1-4 any one is being prepared with raising sow grazing rate, increase sow Average daily milk yield, reduce purposes in the veterinary drug of the inflammation incidence of disease of sow postpartum three.
CN201410160727.6A 2014-04-21 2014-04-21 One kind has promoting blood circulation, antalgic, the Chinese veterinary medicinal composition of lactagogue function and its production and use Expired - Fee Related CN103919964B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103229896A (en) * 2013-03-29 2013-08-07 蚌埠大成食品有限公司 Mutton sheep forage and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103229896A (en) * 2013-03-29 2013-08-07 蚌埠大成食品有限公司 Mutton sheep forage and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
母子安散;无;《http://www.1866.tv/jxwankang/pro/357569/》;20140401 *

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