CN103917096A - 外周阿片样物质拮抗剂化合物的制备方法及所述化合物的中间体 - Google Patents

外周阿片样物质拮抗剂化合物的制备方法及所述化合物的中间体 Download PDF

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Publication number
CN103917096A
CN103917096A CN201280045401.8A CN201280045401A CN103917096A CN 103917096 A CN103917096 A CN 103917096A CN 201280045401 A CN201280045401 A CN 201280045401A CN 103917096 A CN103917096 A CN 103917096A
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CN
China
Prior art keywords
compound
formula
alkyl
independently
compounds
Prior art date
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Pending
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CN201280045401.8A
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English (en)
Chinese (zh)
Inventor
R.E.多尔
B.勒波尔唐奈克
P.马丁
C.S.莫斯纳
F.H.斯皮德勒
D.J.斯皮尔沃格尔
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Adolor Corp
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Adolor Corp
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Publication of CN103917096A publication Critical patent/CN103917096A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280045401.8A 2011-07-18 2012-07-17 外周阿片样物质拮抗剂化合物的制备方法及所述化合物的中间体 Pending CN103917096A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508817P 2011-07-18 2011-07-18
US61/508,817 2011-07-18
PCT/US2012/047082 WO2013012871A1 (en) 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Publications (1)

Publication Number Publication Date
CN103917096A true CN103917096A (zh) 2014-07-09

Family

ID=47558430

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280045401.8A Pending CN103917096A (zh) 2011-07-18 2012-07-17 外周阿片样物质拮抗剂化合物的制备方法及所述化合物的中间体

Country Status (9)

Country Link
US (1) US20150045556A1 (https=)
EP (1) EP2734041A4 (https=)
CN (1) CN103917096A (https=)
AU (1) AU2012284127A1 (https=)
CA (1) CA2842183A1 (https=)
HK (1) HK1199794A1 (https=)
IL (1) IL230506A0 (https=)
IN (1) IN2014DN00137A (https=)
WO (1) WO2013012871A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103804431A (zh) * 2014-02-25 2014-05-21 中国人民解放军第四军医大学 一种手性二茂铁双膦配体及其制备方法
EP3421455B1 (en) * 2017-06-29 2019-03-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib
JP7121794B2 (ja) 2017-08-02 2022-08-18 バーテックス ファーマシューティカルズ インコーポレイテッド ピロリジン化合物を調製するためのプロセス
EP3720849A2 (en) 2017-12-08 2020-10-14 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536858A (en) * 1994-02-12 1996-07-16 Hoffmann-La Roche Inc. Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions
US6057456A (en) * 1997-10-16 2000-05-02 Yale University Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds
US6310213B1 (en) * 1999-06-08 2001-10-30 Hoffmann-La Roche Inc. Ethanesulfonyl-piperidine derivatives
US6531481B2 (en) * 1998-03-10 2003-03-11 Research Triangle Institute Opiate compounds, methods of making and methods of use
US20040039205A1 (en) * 2002-08-08 2004-02-26 Bertrand Le Bourdonnec Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US20100160682A1 (en) * 2008-12-18 2010-06-24 Kieran Durkin Process for synthesis of amino-methyl tetralin derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1321792C (en) * 1987-04-16 1993-08-31 Eli Lilly And Company Piperidine opioid antagonists
US5553858A (en) * 1995-06-28 1996-09-10 Mckoon; Carl T. Golf putter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536858A (en) * 1994-02-12 1996-07-16 Hoffmann-La Roche Inc. Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions
US6057456A (en) * 1997-10-16 2000-05-02 Yale University Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds
US6531481B2 (en) * 1998-03-10 2003-03-11 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6310213B1 (en) * 1999-06-08 2001-10-30 Hoffmann-La Roche Inc. Ethanesulfonyl-piperidine derivatives
US20040039205A1 (en) * 2002-08-08 2004-02-26 Bertrand Le Bourdonnec Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US20100160682A1 (en) * 2008-12-18 2010-06-24 Kieran Durkin Process for synthesis of amino-methyl tetralin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOHN A. WERNER等: "Synthesis of trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonists: Application of the Cis-Thermal Elimination of Carbonates to Alkaloid Synthesis", 《J. ORG. CHEM.》, vol. 61, no. 2, 26 January 1996 (1996-01-26) *

Also Published As

Publication number Publication date
HK1199794A1 (en) 2015-07-24
IN2014DN00137A (https=) 2015-05-22
WO2013012871A1 (en) 2013-01-24
CA2842183A1 (en) 2013-01-24
US20150045556A1 (en) 2015-02-12
IL230506A0 (en) 2014-03-31
AU2012284127A1 (en) 2013-05-02
EP2734041A1 (en) 2014-05-28
EP2734041A4 (en) 2015-03-25

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