CN103860692A - Rapid hemostatic medicament for skin wound - Google Patents

Rapid hemostatic medicament for skin wound Download PDF

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Publication number
CN103860692A
CN103860692A CN201410065040.4A CN201410065040A CN103860692A CN 103860692 A CN103860692 A CN 103860692A CN 201410065040 A CN201410065040 A CN 201410065040A CN 103860692 A CN103860692 A CN 103860692A
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parts
radix
anas domestica
ovum anas
quick
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CN201410065040.4A
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Chinese (zh)
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章国金
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Jiangxi Xiang Run Science And Technology Ltd
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Jiangxi Xiang Run Science And Technology Ltd
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Abstract

The invention discloses a rapid hemostatic medicament for skin wound, which is prepared from the following materials in parts by weight: 50-100 parts of dog oil, 200-400 parts of olive oil, 35-70 parts of common cephalanoplos herb, 50-100 parts of sanguisorba officinalis, 35-70 parts of Japanese dock root, 10-30 parts of notoginseng, 10-15 parts of calcium sulfate, and 100-200 parts of duck egg yolk, or 10-15 parts of borneol. After repeated research, comparison and selection, the rapid hemostatic medicament for skin wound is prepared, and has hemostatic, antibacterial, anti-inflammatory, blood invigorating, discutient, astringent, tissue regeneration promoting, and skin protecting efficacies, can quickly form a layer of protective film on the wound to inhibit the infection, so that the growth of skin cells is promoted, and the wound healing is accelerated.

Description

Skin trauma quick-acting haemostatic powder medicine
Technical field
The present invention relates to a kind of pharmaceutical composition, relate in particular to a kind of skin trauma quick-acting haemostatic powder medicine.
Background technology
The medicine of state's internal therapy skin trauma hemostasis at present has: Western medicine, Chinese medicine, dressing spray, injection several types, adopt through domestic various places hospital and skin trauma research institution, clinical data shows that curative effect is general, existing skin trauma medicine, can only be effective in cure to slight skin trauma hemostasis, but not obvious to the hemostasis of degree of depth skin trauma and large area skin wound hemostasis curative effect, and the course for the treatment of is long, easily infect even threat to life property safety.
Summary of the invention
Object of the present invention is exactly the defect that overcomes prior art and relevant medicine, and a kind of have quick-acting haemostatic powder, antiinflammatory, pain relieving, antibacterial, the skin trauma haemostatic medicament of invigorating blood circulation, subside a swelling, restraining granulation promoting, skin protection are provided.
Skin trauma quick-acting haemostatic powder medicine of the present invention is made by weight ratio by following material: dog oil 50-100 part, olive oil 200-400 part, Herba Cirsii 35-70 part, Radix Sanguisorbae 50-100 part, Radix Rumicis Japonici 35-70 part, Radix Notoginseng 10-30 part, calcium sulfate 10-15 part, Ovum Anas domestica yolk 100-200 part.
In skin trauma quick-acting haemostatic powder medicine of the present invention, also can allocate Borneolum Syntheticum 10-15 part into.
The present invention also provides the preparation method of skin trauma quick-acting haemostatic powder medicine, step is as follows: the Ovum Anas domestica egg yolk blending is poured in electronic pot, turn on the power switch, repeatedly fry with scoop, in the time that crack is sent in the bottom of a pan, Herba Cirsii, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Notoginseng, calcium sulfate and/or Borneolum Syntheticum are added in electronic pot, repeatedly fry with scoop, when crack is sent again in the bottom of a pan, dog oil, olive oil are together poured into electronic pot, stir with scoop, in the time that oil temperature rises to 160-180 ℃, close electronic pot switch, after oil temperature cold filtration, pour container into and deposit in.
The method that the present invention gets Ovum Anas domestica egg yolk is: Ovum Anas domestica water is cleaned up, put into pressure cooker, till adding the domestic water water yield that Ovum Anas domestica is covered, cover tightly pressure cooker, turn on the power switch or start electronic energy source switch, when hot air temperature rises to 100-105 ℃, continue after 5-10 minute, by powered-down or electronic energy source switch, after pressure cooker hot air temperature is cooling, pressure cooker cover is opened, mix cold water, Ovum Anas domestica in cooling pan, then cuts Ovum Anas domestica, take out egg yolk, with pulper, egg yolk is blended thereafter.
The method for making of dog oil of the present invention: the oils and fats of Canis familiaris L., put into electronic pot heating and slowly refine, get supernatant till one-tenth liquid.
In preparation method of the present invention, Herba Cirsii, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Notoginseng, Borneolum Syntheticum are used respectively grinder, pulverize, after then filtering with standard 80-100 mesh sieve, add in electronic pot.
Skin trauma quick-acting haemostatic powder medicine of the present invention through repeatedly studying, compare, selected formulated; have that hemostasis, antiinflammatory, pain relieving are antibacterial, the convergence granulation promoting of invigorating blood circulation, subside a swelling; effect of skin protection; can form layer protecting film at wound surface rapidly; suppress to infect; promote Skin Cell growth thereby play, accelerate the effect of wound healing.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in detail.
Embodiment 1:
Ovum Anas domestica water is cleaned up, put into pressure cooker, till adding the domestic water water yield that Ovum Anas domestica is covered, cover tightly pressure cooker, turn on the power switch or start electronic energy source switch, when hot air temperature rises to 100-105 ℃, continue after 5-10 minute, by powered-down or electronic energy source switch, after pressure cooker hot air temperature is cooling, pressure cooker cover is opened, mix cold water, Ovum Anas domestica in cooling pan, then cuts Ovum Anas domestica, take out egg yolk, egg yolk is blended for subsequent use with pulper thereafter.
The oils and fats of Canis familiaris L., put into electronic pot heating and slowly refine, till one-tenth liquid, get supernatant.Take and get dog oil 50kg, olive oil 150 kg, Herba Cirsii 70 kg, Radix Sanguisorbae 50 kg, Radix Rumicis Japonici 40 kg, Radix Notoginseng 10 kg, calcium sulfate 15 kg, Ovum Anas domestica yolk 120kg, Borneolum Syntheticum 14 kg; Herba Cirsii, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Notoginseng, Borneolum Syntheticum are used respectively to grinder, pulverize, then filter with standard 80-100 mesh sieve; The Ovum Anas domestica egg yolk blending is poured in electronic pot, turned on the power switch, repeatedly fry with scoop, in the time that crack is sent in the bottom of a pan, Herba Cirsii after above-mentioned filtration, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Notoginseng, calcium sulfate, Borneolum Syntheticum are added in electronic pot, repeatedly fry with scoop, when crack is sent again in the bottom of a pan, dog oil, olive oil are together poured into electronic pot, with scoop stirring, in the time that oil temperature rises to 160-180 ℃, close electronic pot switch, after oil temperature cold filtration, pour container into and deposit in.
Embodiment 2:
Take dog oil 60kg, olive oil 300 kg, Herba Cirsii 35 kg, Radix Sanguisorbae 100 kg, Radix Rumicis Japonici 70kg, Radix Notoginseng 20kg, calcium sulfate 13kg, Ovum Anas domestica yolk 180kg, Borneolum Syntheticum 11 kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
Embodiment 3:
Take dog oil 60kg, olive oil 300 kg, Herba Cirsii 40kg, Radix Sanguisorbae 90 kg, Radix Rumicis Japonici 35kg, Radix Notoginseng 30kg, calcium sulfate 10kg, Ovum Anas domestica yolk 100kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
Embodiment 4:
Take dog oil 70kg, olive oil 400 kg, Herba Cirsii 50 kg, Radix Sanguisorbae 60kg, Radix Rumicis Japonici 40kg, Radix Notoginseng 25kg, calcium sulfate 12kg, Ovum Anas domestica yolk 200kg, Borneolum Syntheticum 12kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
Embodiment 5:
Take dog oil 80kg, olive oil 180 kg, Herba Cirsii 60kg, Radix Sanguisorbae 70 kg, Radix Rumicis Japonici 50kg, Radix Notoginseng 15kg, calcium sulfate 14kg, Ovum Anas domestica yolk 110kg, Borneolum Syntheticum 15kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
Embodiment 6:
Take dog oil 90kg, olive oil 250 kg, Herba Cirsii 55 kg, Radix Sanguisorbae 80 kg, Radix Rumicis Japonici 60kg, Radix Notoginseng 30kg, calcium sulfate 15kg, Ovum Anas domestica yolk 150kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
Embodiment 7:
Take dog oil 55kg, olive oil 350 kg, Herba Cirsii 60kg, Radix Sanguisorbae 65kg, Radix Rumicis Japonici 45kg, Radix Notoginseng 28kg, calcium sulfate 10kg, Ovum Anas domestica yolk 160kg, Borneolum Syntheticum 10kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
Embodiment 8:
Take dog oil 85kg, olive oil 150 kg, Herba Cirsii 65 kg, Radix Sanguisorbae 75kg, Radix Rumicis Japonici 55kg, Radix Notoginseng 18kg, calcium sulfate 13kg, Ovum Anas domestica yolk 130kg; Make haemostatic medicament of the present invention by method described in embodiment 1.
(1) clinical observation:
1, clinical data: 126 routine bleeding patients, limb trauma 72 examples, breast abdomen back 32 examples, head and neck face 22 examples.Wherein dampen or scratch 50 examples, epidermis laceration 20 examples, incision 32 examples, repeatability epistaxis 12 examples of unknown cause, traumatic epistaxis 8 examples, stab 4 examples.Wherein male's 72 examples, women's 54 examples; 3~18 years old age, 30 examples, 19~60 years old 78 example, 60 years old above 18 example.Above-mentioned case is divided into test group 70 example and matched group 56 examples at random, and wherein two groups of patients are at sex, age, the equal no difference of science of statistics of hemorrhage type.
2, medication:
Test group: traumatic hemorrhage patient uses and spreads on hemorrhage place immersed with the sterile gauze of medicinal liquid of the present invention after suitable debridement, disinfection, through suitable external pressurization or wrapping pressurization, capable other relevant processing again after blood stops.First nasal bleeding person should remove remaining hematocele and the sludged blood of nasal cavity, with the sterilized cotton ball compressing petechia that is soaked with medicinal liquid of the present invention.The consumption of concrete medicine takes the circumstances into consideration to use according to patient's wound size.
Matched group: traumatic hemorrhage patient uses YUNNAN BAIYAO powder to be spread on hemorrhage place after suitable debridement, disinfection, then the pressurization of external use sterile gauze or wrapping pressurization, capable other relevant processing again after blood stops.First nasal bleeding person also should remove remaining hematocele and the sludged blood of nasal cavity, gets suitable position YUNNAN BAIYAO powder is spread on to petechia, with the capable suitable compressing of sterilized cotton ball.
3, curative effect judgement: start the clock immediately after medicine contact with bleeding wounds, press and remove after dressing nothing bleeder again after 2 minutes to press 2 minutes, 5 minutes or 10 minutes as curative effect judging point, to unclamp, be considered as stopping blooding.Wherein hemostasis is 2 minutes immediately, and hemostasis is well 5 minutes, and stopping blooding invalid is 10 minutes.
4, statistical procedures: the effect of two groups for the treatment of cases is carried out X 2 test, and P < 0.05 is for there being statistical significance.
5, correlated results experimental result: two groups of overall hemostatic healing efficacy no difference of science of statistics of patient; But two groups of obvious differences of haemostatic effect immediately, the successful of test group is better than matched group (P < 0.05).
Two groups of curative effect comparisons
Hemostasis (example) hemostasis immediately good (example) stop blooding invalid (example)
Test group (70 example) 48 ▲ 19 3
Matched group (56 example) 28 23 5
Two groups of overall hemostatic healing efficacies of patient (hemostasis+hemostasis is good immediately) no difference of science of statistics, χ 2=1.13, P > 0.05; But compared with matched group, haemostatic effect test group is obviously better than matched group, χ immediately 2=4.48, ▲ P < 0.05.
(2) model case
Beam so-and-so, female, 48 years old, profession.Main suit's vegetable knife when working in kitchen before 20 minutes scratches left hand arm accidentally, popular more than, suddenly sends to hospital medical.Check that left forearm skin has one to reach the breach of 3 centimetres, still haemophilia, is diagnosed as left forearm incision.Give immediately to use and spread on hemorrhage place immersed with the sterile gauze of the peaceful liquid of this quick-acting haemostatic powder after normal saline and ethanol clean, through suitable external pressurization.Observe after two minutes, remove and in 2 minutes, have no obvious blood after dressing and ooze out.Continue to wrap up, within the 3rd day, be almost recovered, without wound infection.
This clinical experiment confirmation is compared with matched group, use skin wound treatment liquid, treatment skin trauma has fairly obvious clinical efficacy, especially hemostasis, antiinflammatory, antibacterial, receive sword, granulation promoting, skin protection and promote the speed of depth wound healing and epithelial cell growth mechanism special in aobvious.

Claims (6)

1. a skin trauma quick-acting haemostatic powder medicine, is characterized in that: made by weight ratio by following material: dog oil 50-100 part, olive oil 200-400 part, Herba Cirsii 35-70 part, Radix Sanguisorbae 50-100 part, Radix Rumicis Japonici 35-70 part, Radix Notoginseng 10-30 part, calcium sulfate 10-15 part, Ovum Anas domestica yolk 100-200 part.
2. skin trauma quick-acting haemostatic powder medicine according to claim 1, is characterized in that: be furnished with Borneolum Syntheticum 15-40 part.
3. the preparation method of skin trauma quick-acting haemostatic powder medicine according to claim 1 and 2, it is characterized in that: step is as follows: the Ovum Anas domestica egg yolk blending is poured in electronic pot, turn on the power switch, repeatedly fry with scoop, in the time that crack is sent in the bottom of a pan, Herba Cirsii, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Notoginseng, calcium sulfate and/or Borneolum Syntheticum add in electronic pot, repeatedly fry with scoop, when crack is sent again in the bottom of a pan, dog oil, olive oil is together poured electronic pot into, stir with scoop, in the time that oil temperature rises to 160-180 ℃, close electronic pot switch, after oil temperature cold filtration, pouring container into deposits in.
4. the preparation method of skin trauma quick-acting haemostatic powder medicine according to claim 1 and 2, it is characterized in that: the method for getting Ovum Anas domestica egg yolk is: Ovum Anas domestica water is cleaned up, put into pressure cooker, till adding the domestic water water yield that Ovum Anas domestica is covered, cover tightly pressure cooker, turn on the power switch or start electronic energy source switch, when hot air temperature rises to 100-105 ℃, continue after 5-10 minute, by powered-down or electronic energy source switch, after pressure cooker hot air temperature is cooling, pressure cooker cover is opened, mix cold water, Ovum Anas domestica in cooling pan, then Ovum Anas domestica is cut, take out egg yolk, thereafter with pulper, egg yolk is blended.
5. the preparation method of skin trauma quick-acting haemostatic powder medicine according to claim 1 and 2, is characterized in that: the method for making of dog oil: the oils and fats of Canis familiaris L., put into electronic pot heating and slowly refine, till one-tenth liquid, get supernatant.
6. the preparation method of skin trauma quick-acting haemostatic powder medicine according to claim 1 and 2, it is characterized in that: Herba Cirsii, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Notoginseng, Borneolum Syntheticum are used respectively grinder, pulverize, after then filtering with standard 80-100 mesh sieve, add in electronic pot.
CN201410065040.4A 2014-02-26 2014-02-26 Rapid hemostatic medicament for skin wound Pending CN103860692A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105434695A (en) * 2015-12-07 2016-03-30 黑龙江省智诚医药科技有限公司 A kind of compound Zhixuening dispersible tablet and preparation method thereof

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CN103349791A (en) * 2013-07-29 2013-10-16 广西信业生物技术有限公司 Novel microporous medical hemostatic material and preparation method thereof
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JP2013231025A (en) * 2012-04-02 2013-11-14 Gifu Univ Hemostasis promoter including fucoidan
CN103349791A (en) * 2013-07-29 2013-10-16 广西信业生物技术有限公司 Novel microporous medical hemostatic material and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105434695A (en) * 2015-12-07 2016-03-30 黑龙江省智诚医药科技有限公司 A kind of compound Zhixuening dispersible tablet and preparation method thereof

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Application publication date: 20140618