CN103830405A - Suppository for treating haemorrhoids - Google Patents
Suppository for treating haemorrhoids Download PDFInfo
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- CN103830405A CN103830405A CN201410088628.1A CN201410088628A CN103830405A CN 103830405 A CN103830405 A CN 103830405A CN 201410088628 A CN201410088628 A CN 201410088628A CN 103830405 A CN103830405 A CN 103830405A
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- 208000014617 hemorrhoid Diseases 0.000 title claims abstract description 19
- 239000000829 suppository Substances 0.000 title claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- 238000010992 reflux Methods 0.000 claims abstract description 4
- 241000972672 Phellodendron Species 0.000 claims abstract 7
- 239000012141 concentrate Substances 0.000 claims abstract 6
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract 3
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract 3
- 241000246044 Sophora flavescens Species 0.000 claims abstract 3
- 239000000463 material Substances 0.000 claims abstract 3
- 239000011159 matrix material Substances 0.000 claims abstract 3
- 238000000605 extraction Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims description 4
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000012943 hotmelt Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 7
- 230000008961 swelling Effects 0.000 abstract description 7
- 239000012530 fluid Substances 0.000 abstract description 6
- 230000036407 pain Effects 0.000 abstract description 5
- 206010010774 Constipation Diseases 0.000 abstract description 3
- 230000000740 bleeding effect Effects 0.000 abstract description 3
- 238000009835 boiling Methods 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 230000023597 hemostasis Effects 0.000 description 5
- 239000012567 medical material Substances 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229950009789 cetomacrogol 1000 Drugs 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 201000007772 internal hemorrhoid Diseases 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010014025 Ear swelling Diseases 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗痔疮的栓剂，属于治疗痔疮的外用中药；由黄柏、黄芩、五倍子、苦参按以下方法制成：1）将黄柏加入8倍重量的乙醇中，回流提取三次，浓缩滤液得黄柏浓缩液；用剩余三种药材14倍重量的沸水煎煮黄芩10分钟，加入五倍子和苦参煎煮两小时，过滤；然后再加入12倍重量的水煎煮两次，合并三次滤液、浓缩得相对密度为1.10～1.15的流浸膏；流浸膏中加入乙醇，静置18小时，过滤、浓缩得浓缩提取液；将浓缩提取液与黄柏浓缩液合并，真空干燥、粉碎，得药粉；将药粉与基质按4∶6的重量比混匀后注模、冷却即得。本发明对内痔、外痔、混合痔引起的出血、肿胀、疼痛、便秘等均有很好的疗效；是一种治疗痔疮的外用药。The invention discloses a suppository for treating hemorrhoids, which belongs to external Chinese medicine for treating hemorrhoids; it is prepared from Phellodendron Phellodendri, Scutellaria baicalensis, Galla gallinaceus and Sophora flavescens according to the following method: 1) Add Cortex Phellodendron to ethanol with 8 times the weight, reflux extraction three times, and concentrate The filtrate was used to obtain Phellodendron concentrator; decoct Scutellaria baicalensis with 14 times the weight of the remaining three medicinal materials in boiling water for 10 minutes, add gallnuts and flavescens and decoct for two hours, filter; then add 12 times the weight of water to decoct twice, and combine the filtrates three times , concentrated to obtain a fluid extract with a relative density of 1.10 to 1.15; add ethanol to the fluid extract, let it stand for 18 hours, filter and concentrate to obtain a concentrated extract; combine the concentrated extract with the Phellodendron cortex concentrate, vacuum dry, pulverize, and obtain Medicinal powder: mix the medicinal powder and matrix according to the weight ratio of 4:6, inject into the mold, and cool down. The invention has good curative effect on bleeding, swelling, pain and constipation caused by internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and is an external medicine for treating hemorrhoids.
Description
Technical field
The present invention relates to a kind of external application Chinese medicine for the treatment of hemorrhoid, relate in particular to a kind of suppository for the treatment of hemorrhoid.
Background technology
As everyone knows, hemorrhoid are a kind of commonly encountered diseases, frequently-occurring disease, and the age is in the majority with 20～40 years old person, can increase the weight of gradually with the increase at age; Therefore there is saying of " ten people's nine hemorrhoid ".At present, although the external application Chinese medicine for the treatment of hemorrhoid is a lot, curative effect is had nothing in common with each other, and ubiquity flavour of a drug are more, complicated process of preparation, high in cost of production defect.
Summary of the invention
For the above-mentioned defect existing in prior art, the suppository that the present invention aims to provide that a kind of flavour of a drug are few, good effect, low price, medication are treated hemorrhoid easily.
To achieve these goals, technical scheme of the present invention is made up of the medical material of following weight portion: Cortex Phellodendri 18～21, Radix Scutellariae 8～10, Galla Chinensis 10～12, Radix Sophorae Flavescentis 1～3, and its preparation method is as follows:
1) ethanol that is 70% by 8 times of weight concentrations adds in the Cortex Phellodendri of chopping, reflux, extract, three times, each two hours; Merging filtrate, concentration and recovery ethanol, obtain Cortex Phellodendri concentrated solution;
2) decoct Radix Scutellariae 10 minutes with the boiling water of 14 times of weight of three kinds of medical materials of residue, add Galla Chinensis and Radix Sophorae Flavescentis to decoct two hours, filter; And then the decocting that adds 12 times of weight boils twice, each two hours, merge three times filtrate, be concentrated into room temperature lower density and be 1.10～1.15 fluid extract;
3) to adding ethanol in described fluid extract, guaranteeing that ethanol content reaches 60%, leave standstill 18 hours, filter, concentration and recovery ethanol, obtain concentrated extracting solution;
4) above-mentioned concentrated extracting solution and described Cortex Phellodendri concentrated solution are merged, vacuum drying, pulverizing, obtain medicated powder;
5) above-mentioned medicated powder and substrate are mixed to rear injection molding, cooling by the weight ratio of 4:6; The cetomacrogol 1000 that described substrate is 38% by percentage by weight, 59% Macrogol 4000,3% polyethylene glycol 6000 melt compounding form.
In technique scheme, Cortex Phellodendri hardship, cold; There are heat clearing and damp drying, pathogenic fire purging to remove effect of steaming, detoxification sore treatment; For damp-heat dysentery, sore swollen toxin, eczema pruritus, it is monarch drug.Radix Scutellariae hardship, cold; There is effect of heat clearing and damp drying, eliminating fire and detoxication, hemostasis; For hygropyrexia, damp and hot feeling of fullness, heat in blood is told nosebleed, carbuncle sore tumefacting virus, is ministerial drug.Gallic acid, puckery, cold; There is effect of the pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating hemostasis, astringent therapy sore; Be used for having blood in stool hemorrhoidal bleeding, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten are adjuvant drug.Radix Sophorae Flavescentis hardship, cold; There is effect of heat clearing and damp drying, parasite killing, diuresis; For hematodiarrhoea have blood in stool, swelling of the vulva pudendal pruritus, eczema eczema, skin pruritus, scabies leprosy, for making medicine.
Sour, puckery, bitter, the cold and use in full side, complements each other, and brings out the best in each other, and hemorrhage, swelling that internal hemorrhoid, external hemorrhoid, mixed hemorrhoid are caused, pain, constipation etc. all have good curative effect.
Compared with the prior art, acid of the present invention, puckery, bitter, cold all medicines use, complement each other, and brings out the best in each other; There is reducing swelling and alleviating pain, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis effect.Flavour of a drug of the present invention are few, preparation simple, cost is low, medication is convenient, and hemorrhage, swelling that internal hemorrhoid, external hemorrhoid, mixed hemorrhoid are caused, pain, constipation etc. all have good curative effect.
Using method: suppository of the present invention is filled in anus, a twice-daily, each; During medication, avoid greasy, maror.
Below to adopt medicine of the present invention to SD mice is eased pain, antiinflammatory, hemostasis pharmacodynamic experiment obtain three groups of data." under medical material Cortex Phellodendri item of Chinese Pharmacopoeia 2005 version, stipulate, Cortex Phellodendri medical material consumption is 3～12g, show that according to Cortex Phellodendri shared ratio and pharmacopeia Cortex Phellodendri medical material maximum dosage-feeding in prescription dosage is 7.8 g/ days.Experiment adopts gastric infusion, and 40 of the mices of 18～22g are divided into four groups at random, and 10 every group, male and female half and half.The blank group of each experiment is filled with normal saline, is that 0.026g/10g, middle dosage group are that 0.013g/10g, positive controls are 0.00078g/10g through the high dose group dosage of each experiment that converts.
1, analgesic activity is tested (writhing method): successive administration 5 days, last administration is every mouse peritoneal injection acetic acid 0.2ml after 1 hour, observes the writhing number of times (abdominal part indent, stretching, extension hind leg, afterbody are raised) occurring in 15min.Writhing data are in table 1.
Above-mentioned experimental data adopts the analysis of SPSS software statistics, assembly t check for calculating chart.Can find out from above-mentioned data, compared with matched group: * P < 0.05, * * P < 0.01.
2, antiinflammatory action experiment (ear swelling method): successive administration 5 days, after last administration, after 1 hour, dimethylbenzene is applied to mouse right ear two sides with 0.02ml/ dosage only, left ear is not coated with as blank; After 1 hour, de-cervical vertebra is put to death, and cuts the left and right ear of mice, lays two auricles with card punch along two ear same area, weighs respectively; Relative weight using two ears is poor as swelling level index calculating mice ear degree [that is: (auris dextra weight-left ear weight)/left ear weight × 100%].Swelling data are in table 2.
Can find out from above-mentioned data, compared with matched group: * * P < 0.01.
3, anastalsis experiment (docking method): successive administration 5 days, after last administration, cut off at the 1 hour point 0.5cm of the tail tail by each Mus place, after blood flows out voluntarily, starts timing, sucked blood 1 time every 15 seconds with filter paper, until blood stops naturally, be calculated as the bleeding time.Bleeding stopping period is in table 3.
Can find out from above-mentioned data, compared with matched group: * * P < 0.01
Can find out from the result of above-mentioned three experiments, administration group and blank group have significant difference, illustrate that the present invention has the effect of good analgesia, antiinflammatory, hemostasis.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described:
Embodiment 1
1) get 18 grams of choppings of Cortex Phellodendri, add the ethanol that 144 grams of concentration are 70%, reflux, extract, three times, each two hours; Merging filtrate, concentration and recovery ethanol, obtain Cortex Phellodendri concentrated solution;
2) 10 grams of Radix Scutellariaes are added in the boiling water of 322 grams and decoct 10 minutes, add 3 grams of 10 grams of Galla Chinensiss, Radix Sophorae Flavescentis to decoct two hours, filter; And then add 276 grams of decoctings to boil twice, each two hours, and merge three times filtrate, be concentrated into room temperature lower density and be 1.10～1.15 fluid extract;
3) to adding ethanol in described fluid extract, guaranteeing that ethanol content reaches 60%, leave standstill 18 hours, filter, concentration and recovery ethanol, obtain concentrated extracting solution;
4) above-mentioned concentrated extracting solution and described Cortex Phellodendri concentrated solution are merged, vacuum drying, pulverizing, obtain medicated powder;
5) above-mentioned medicated powder and substrate are mixed to rear injection molding, cooling by the weight ratio of 4:6, guarantee that every weight reaches 1.3 grams; Described substrate is melted and mixes through 70～80 ℃ of hot bath heating by 38%, 59%, 3% mass percent by cetomacrogol 1000, Macrogol 4000, polyethylene glycol 6000.
Embodiment 2
Each step is with embodiment 1, and wherein the Cortex Phellodendri in step 1) is that 21 grams, ethanol are 168 grams; Step 2) in Radix Scutellariae be that 8 grams, Galla Chinensis are 12 grams, Radix Sophorae Flavescentis 1, decocting for the first time water consumption is 294 grams, decocts for the second time and for the third time water consumption and is 252 grams.
Embodiment 3
Each step is with embodiment 1, and wherein the Cortex Phellodendri in step 1) is that 20 grams, ethanol are 160 grams; Step 2) in Radix Scutellariae be that 9 grams, Galla Chinensis are 11 grams, Radix Sophorae Flavescentis 2, decocting for the first time water consumption is 308 grams, decocts for the second time and for the third time water consumption and is 264 grams.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410088628.1A CN103830405A (en) | 2014-03-12 | 2014-03-12 | Suppository for treating haemorrhoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410088628.1A CN103830405A (en) | 2014-03-12 | 2014-03-12 | Suppository for treating haemorrhoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103830405A true CN103830405A (en) | 2014-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410088628.1A Pending CN103830405A (en) | 2014-03-12 | 2014-03-12 | Suppository for treating haemorrhoids |
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| Country | Link |
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| CN (1) | CN103830405A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997907A (en) * | 2015-09-08 | 2015-10-28 | 顾桂芹 | Medicine for curing haemorrhoids |
| CN105233180A (en) * | 2015-11-16 | 2016-01-13 | 庄小侃 | Drug for treating internal hemorrhoid due to damp-heat pouring downward syndrome |
| CN113797253A (en) * | 2021-10-26 | 2021-12-17 | 四川肛肠医院有限公司 | Shuanghuangchangning liquid |
| CN114767784A (en) * | 2022-03-18 | 2022-07-22 | 嘉兴市中医医院 | Preparation method of medicine for treating hemorrhoids |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045104A (en) * | 2007-04-24 | 2007-10-03 | 张秀丽 | External use suppository for treating hemorrhoids |
| CN101455771A (en) * | 2008-12-25 | 2009-06-17 | 赵建良 | External traditional Chinese medicine ointment for treating hemorrhoid |
-
2014
- 2014-03-12 CN CN201410088628.1A patent/CN103830405A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045104A (en) * | 2007-04-24 | 2007-10-03 | 张秀丽 | External use suppository for treating hemorrhoids |
| CN101455771A (en) * | 2008-12-25 | 2009-06-17 | 赵建良 | External traditional Chinese medicine ointment for treating hemorrhoid |
Non-Patent Citations (2)
| Title |
|---|
| 张媛等: "近十年来国内肛肠病中药栓剂研究概况", 《辽宁中医药大学学报》, vol. 16, no. 2, 28 February 2014 (2014-02-28), pages 169 - 172 * |
| 王明轩: "三黄熏洗汤治疗炎性痔106 例疗效观察", 《湖南中医杂志》, vol. 20, no. 4, 31 July 2004 (2004-07-31), pages 32 - 33 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997907A (en) * | 2015-09-08 | 2015-10-28 | 顾桂芹 | Medicine for curing haemorrhoids |
| CN104997907B (en) * | 2015-09-08 | 2018-06-08 | 顾桂芹 | A kind of drug for being used to treat hemorrhoid |
| CN105233180A (en) * | 2015-11-16 | 2016-01-13 | 庄小侃 | Drug for treating internal hemorrhoid due to damp-heat pouring downward syndrome |
| CN113797253A (en) * | 2021-10-26 | 2021-12-17 | 四川肛肠医院有限公司 | Shuanghuangchangning liquid |
| CN114767784A (en) * | 2022-03-18 | 2022-07-22 | 嘉兴市中医医院 | Preparation method of medicine for treating hemorrhoids |
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Application publication date: 20140604 |