CN103816370A - Chinese medicament group for assisting chemotherapy - Google Patents
Chinese medicament group for assisting chemotherapy Download PDFInfo
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- CN103816370A CN103816370A CN201410096696.2A CN201410096696A CN103816370A CN 103816370 A CN103816370 A CN 103816370A CN 201410096696 A CN201410096696 A CN 201410096696A CN 103816370 A CN103816370 A CN 103816370A
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Abstract
The invention discloses a Chinese medicament group for assisting chemotherapy, relating to the field of medication. The Chinese medicament group comprises trichoderma pseudokoningii extracellular polysaccharide, astragalus root, red ginseng, Chinese angelica root, dwarf lilyturf turber, suberect spatholobus stem, sesame, common yam rhizome, lotus plumule, licorice root, lucid ganoderma and spreading hedyotis herb. The Chinese medicament group is prepared according to treatment principles of safety, reliability, healthy energy supporting of the traditional Chinese medicine, blood activation, heat clearing and the like, and can reduce adverse use effects according to regulation of medicament properties among the medicaments, and meanwhile, the Chinese medicament group can solidify the fundamental essence of life to ensure that both qi and yin are invigorated and nourished, and can also inhibit the rapid development of tumors and treat both symptoms and root causes, so that the Chinese medicament group can be taken for a long time.
Description
Technical field
The present invention relates to Drug therapy field, particularly relate to the auxiliary Chinese drug-treated group of using of a kind of chemotherapy.
Background technology
Operation is at present the first-selected treatment means for the treatment of cancer, and general cancer all has postoperative metastasis and relapse rate, except part early stage patient, all need to accept chemotherapy, chemotherapy no doubt can be eliminated the small metastasis in patient body, increase and cure chance, but chemotherapeutics also has damage to normal cell in killing off tumor cells, find Chinese medicine therefore be badly in need of using traditional medical theory, in treatment malignant tumor, also can obviously reduce the chemotherapy adverse effect traditional Chinese medical science and think that insufficiency of the spleen, deficiency of the kidney, healthy energy cannot count as a fault this, damp and hot fire-toxin, the mark that expectorant poison blood stasis is disease, effective treatment of tumor post-operation being carried out to adjuvant therapy of tumors from the angle of traditional Chinese medical science strengthening the body resistance is mainly still hands art so far, chemotherapy, radiotherapy, but, there is 80% patient will pass through chemotherapy, radiotherapy obtains the existence of longer time, but chemotherapy cause as bone marrow transplantation, hypoimmunity, the toxicities such as gastrointestinal reaction, make patient be difficult to adhere to, the General Symptoms that chemotherapeutics causes comprises dizziness, fatigue and weak, lethargy, be off one's feed, insomnia and dreamful sleep, dry mouth and lack of saliva, defecation imbalance etc., as be aided with treatment by Chinese herbs and can increase curative effect, can avoid to a certain extent or alleviate again the toxicity of chemicotherapy, extend patient's life cycle and life quality.
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Summary of the invention
For overcoming the deficiency in prior art, the object of the invention is to provide the auxiliary Chinese drug-treated group of using of a kind of chemotherapy.
For realizing object of the present invention, technical scheme of the present invention is as follows:
A kind of chemotherapy is auxiliary by Chinese drug-treated group, comprises trichoderma pseudokoningii exocellular polysaccharide, the Radix Astragali, Radix Ginseng Rubra, Radix Angelicae Sinensis, Radix Ophiopogonis, Caulis Spatholobi, Semen Sesami, Rhizoma Dioscoreae, Plumula Nelumbinis, Radix Glycyrrhizae, Ganoderma, Herba Hedyotidis Diffusae.
Above-mentioned a kind of chemotherapy is auxiliary by Chinese drug-treated group, wherein, trichoderma pseudokoningii exocellular polysaccharide 0.5-1 part, 30 ~ 50 parts of the Radixs Astragali, 20 ~ 30 parts of Radix Ginseng Rubra, 20 ~ 30 parts of Radix Angelicae Sinensis, 5 ~ 15 parts of Radix Ophiopogonis, 8 ~ 12 parts of Caulis Spatholobis, Semen Sesami 10 ~ 20,5 ~ 10 parts of Rhizoma Dioscoreaes, 5 ~ 10 parts of Plumula Nelumbiniss, 5 ~ 10 parts, Radix Glycyrrhizae, 10 ~ 20 parts of Ganodermas, 8 ~ 12 parts of Herba Hedyotidis Diffusaes.
Above-mentioned a kind of chemotherapy is auxiliary by Chinese drug-treated group, wherein, trichoderma pseudokoningii exocellular polysaccharide 0.5-1 part, 30 ~ 50 parts of the Radixs Astragali, 20 ~ 30 parts of Radix Angelicae Sinensis, 5 ~ 15 parts of Radix Ophiopogonis, 5 ~ 10 parts of Rhizoma Dioscoreaes, 5 ~ 10 parts of Plumula Nelumbiniss, 5 ~ 10 parts, Radix Glycyrrhizae, 10 ~ 20 parts of Ganodermas, 8 ~ 12 parts of Herba Hedyotidis Diffusaes.
Chemotherapy is auxiliary by the preparation process in Chinese drug-treated group, comprises the following steps:
(1) preparation method of cultivation trichoderma pseudokoningii exocellular polysaccharide:
A, trichoderma pseudokiningii is inoculated in after the activation of PDA culture medium, in flat board access fluid medium, at 28 ℃, under 120 rpm/min oscillating conditions, cultivate 10 days, with four layers of filtered through gauze fermentation liquid, remove after mycelia and spore, centrifugal, collect supernatant, be placed in Rotary Evaporators, 60 ℃ are evaporated to 1/3 of original volume, concentrated solution is entered to 95% ethanol hold over night of 3 ~ 4 times of volumes, 12000 rpm/min are centrifugal, collecting precipitation, precipitation is dissolved in to distilled water, centrifuging and taking supernatant, and D301-R type resin column decolouring excessively, collect eluent, then use Sevag method deproteinization, repeatedly until without protein, supernatant distillation is removed to organic solvent, after lyophilization, obtain crude extracellular polysaccharide sample,
B, crude polysaccharides is dissolved in to PH is in 8.2 Tris-HCl buffer, centrifugal, get DEAE Sepharose Fast Flow ion exchange column on supernatant, with carrying out gradient elution containing the Tris-HCl buffer of NaCl, automatically fraction collector is collected, and adopts phenolsulfuric acid method to merge and collects single peak district eluent, concentrating under reduced pressure postlyophilization, then further use Sephadex G-75 purification, obtain extracellular polysaccharide sterling;
(2) get Radix Ginseng Rubra, Radix Ophiopogonis, the Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, with twice of reflux, extract, in 30 ~ 40% ethanol, each 70 ~ 80 minutes, obtain ethanol extract for subsequent use, medicinal residues are decocted with water to 30min, concentrated filtrate, to the clear paste that relative density is 1.03 ~ 1.18, merge with ethanol extract, rotary evaporation reclaims ethanol, drying under reduced pressure, is crushed to fine powder for subsequent use;
(3) Semen Sesami, Rhizoma Dioscoreae, Plumula Nelumbinis, Ganoderma are ground to form to fine powder in mortar, mix with gained fine powder in step (2), carry out wet granulation, by the agent of granulator granulation, in incapsulating.
Above-mentioned a kind of chemotherapy is auxiliary by Chinese drug-treated group, and wherein, described in step (1) A, the component of PDA culture medium is Rhizoma Solani tuber osi 100g, glucose 20g, agar 20g, water 1000ml.
The auxiliary preparation process by Chinese drug-treated group of above-mentioned a kind of chemotherapy, wherein, described in step (1) A, in Sevag method, adopting solvent is that the volume ratio of chloroform and n-butyl alcohol is 4:1.
The auxiliary preparation process by Chinese drug-treated group of above-mentioned a kind of chemotherapy, wherein, while carrying out gradient elution in step (1) B, NaCl concentration range is 0-0.5 M.
Beneficial effect of the present invention: in formula, trichoderma pseudokoningii exocellular polysaccharide is that the trichoderma pseudokiningii that can obtain from corn straw carries out cell culture and then extracts, apoptosis that can inducing tumor cell, thus be used for the treatment of tumor;
Its patent medicine bitter in the mouth, light of Herba Hedyotidis Diffusae, cold in nature, main effect is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness, wherein contains the material that has Quercetin etc. can kill cancerous cell, has anticancer function;
Ganoderma nature and flavor are sweet flat, for the meridian dredging, tonifying for the deficiency, control asthenia, cough, asthma, insomnia and dyspepsia;
Radix Ginseng Rubra and Radix Ophiopogonis be compatibility use clinically, and the medicinal ingredient of SHENMAI ZHUSHEYE is on the market exactly these two kinds of materials, for the adjuvant drug of tumor;
Radix Astragali nature and flavor are sweet, and tepor is returned lung, spleen, liver, kidney channel.Be used for the treatment of spontaneous sweating due to deficiency of QI, syndrome of deficiency of spleen qi, weak asthenia, have loose bowels, sinking of QI of middle-JIAO, internal organs prolapsus, the indigestion and loss of appetite all diseases of lack of appetite, because the spleen being in charge of dampness, insufficiency of the spleen can not transporation of body fluid in lung, so dampness blocking in middle-JIAO, characteristic of dampness being descending, so the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is subject to wet and loose stool, insufficiency of the spleenly be difficult to help the strong fortune of stomach, so lack of appetite is indigestion and loss of appetite, difficult think of diet, it is lunar that this medicine enters brothers, so abundant lung-QI can regulating fluid apssage, loose essence is to flesh table, excessive splenoqi can the cloudy essence of transporting be gone up defeated in lung, the situation of the deficiency of both QI and blood to oncotherapy regulates, with Ganoderma, the materials such as Radix Ginseng Rubra can enhancing human body immunity power,
Plumula Nelumbinis nature and flavor hardship, cold, clear away heart-fire, reduce phlegm and internal heat, hemostasis, arresting seminal emission, control vexed dreaminess, thirsty, spit blood, seminal emission, conjunctival congestion and swelling pain, goes heart-fire, emotion when adjustment for the treatment of, also all contains the composition that regulates and suppress tumor in Radix Angelicae Sinensis, Caulis Spatholobi and Semen Sesami, carry out compatibility use between these Chinese medicines, regulate each other nature and flavor
The neurotoxicity that Caulis Spatholobi causes while being used for the treatment of the drug use of plant bases is as vincristine, paclitaxel, can cause that numb limbs and tense tendons, general weakness, knee jerk are low, enteroparalysis, constipation, ataxia etc.;
Chinese medicine composition in the present invention is mainly prepared from safe and reliable and traditional Chinese medical science strengthening the body resistance, the Therapeutic Principle such as heat clearing away that invigorate blood circulation, be in harmonious proportion and reduce bad result of use according to the property of medicine between medicine, the Guyuan of reinforcing simultaneously, make gas, cloudy all that tonification is nourished, also can suppress the fast development of tumor, treating both the principal and secondary aspects of a disease, can long-term taking.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with the specific embodiment, further set forth the present invention.
embodiment 1:
A kind of chemotherapy is auxiliary by Chinese drug-treated group, comprises 0.5 part of trichoderma pseudokoningii exocellular polysaccharide, 50 parts of the Radixs Astragali, 20 parts of Radix Ginseng Rubra, 20 parts of Radix Angelicae Sinensis, 15 parts of Radix Ophiopogonis, 10 parts of Caulis Spatholobis, Semen Sesami 15,5 parts of Rhizoma Dioscoreaes, 5 parts of Plumula Nelumbiniss, 10 parts, Radix Glycyrrhizae, 10 parts of Ganodermas, 12 parts of Herba Hedyotidis Diffusaes.
Chemotherapy is auxiliary by the preparation process in Chinese drug-treated group, comprises the following steps:
(1) preparation method of cultivation trichoderma pseudokoningii exocellular polysaccharide:
A, trichoderma pseudokiningii is inoculated in after the activation of PDA culture medium, in flat board access fluid medium, at 28 ℃, under 120 rpm/min oscillating conditions, cultivate 10 days, with four layers of filtered through gauze fermentation liquid, remove after mycelia and spore, centrifugal, collect supernatant, be placed in Rotary Evaporators, 60 ℃ are evaporated to 1/3 of original volume, concentrated solution is entered to 95% ethanol hold over night of 4 times of volumes, 12000 rpm/min are centrifugal, collecting precipitation, precipitation is dissolved in to distilled water, centrifuging and taking supernatant, and D301-R type resin column decolouring excessively, collect eluent, then use Sevag method deproteinization, repeatedly until without protein, supernatant distillation is removed to organic solvent, after lyophilization, obtain crude extracellular polysaccharide sample,
Wherein, the component of PDA culture medium is Rhizoma Solani tuber osi 100g, glucose 20g, agar 20g, water 1000ml, and in described Sevag method, adopting solvent is that the volume ratio of chloroform and n-butyl alcohol is 4:1
B, crude polysaccharides is dissolved in to PH is in 8.2 Tris-HCl buffer, centrifugal, get DEAE Sepharose Fast Flow ion exchange column on supernatant, with carrying out gradient elution containing the Tris-HCl buffer of NaCl, automatically fraction collector is collected, and adopts phenolsulfuric acid method to merge and collects single peak district eluent, concentrating under reduced pressure postlyophilization, then further use Sephadex G-75 purification, obtain extracellular polysaccharide sterling;
Wherein, while carrying out gradient elution, NaCl concentration range is 0-0.5 M.
(2) get Radix Ginseng Rubra, Radix Ophiopogonis, the Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, with twice of reflux, extract, in 30 ~ 40% ethanol, each 80 minutes, obtain ethanol extract for subsequent use, medicinal residues are decocted with water to 30min, concentrated filtrate, to the clear paste that relative density is 1.03, merge with ethanol extract, rotary evaporation reclaims ethanol, drying under reduced pressure, is crushed to fine powder for subsequent use;
(3) Semen Sesami, Rhizoma Dioscoreae, Plumula Nelumbinis, Ganoderma are ground to form to fine powder in mortar, mix with gained fine powder in step (2), carry out wet granulation, by the agent of granulator granulation, in incapsulating.
embodiment 2:all the other are identical with described embodiment 1, difference is, chemotherapy is auxiliary comprises 1 part of trichoderma pseudokoningii exocellular polysaccharide, 30 parts of the Radixs Astragali, 30 parts of Radix Angelicae Sinensis, 10 parts of Radix Ophiopogonis, 10 parts of Rhizoma Dioscoreaes, 10 parts of Plumula Nelumbiniss, 10 parts, Radix Glycyrrhizae, 18 parts of Ganodermas, 8 parts of Herba Hedyotidis Diffusaes by Chinese drug-treated group.
embodiment 3:all the other are identical with described embodiment 1, difference is, chemotherapy is auxiliary comprises 1 part of trichoderma pseudokoningii exocellular polysaccharide, 40 parts of the Radixs Astragali, 30 parts of Radix Ginseng Rubra, 25 parts of Radix Angelicae Sinensis, 5 parts of Radix Ophiopogonis, 8 parts of Caulis Spatholobis, Semen Sesami 20,7 parts of Rhizoma Dioscoreaes, 8 parts of Plumula Nelumbiniss, 5 parts, Radix Glycyrrhizae, 15 parts of Ganodermas, 10 parts of Herba Hedyotidis Diffusaes by Chinese drug-treated group.
In above-mentioned three embodiment,
This chemotherapy is auxiliary to be mainly prepared from safe and reliable and traditional Chinese medical science strengthening the body resistance, the Therapeutic Principle such as heat clearing away that invigorate blood circulation by Chinese drug-treated group, be in harmonious proportion and reduce bad result of use according to the property of medicine between medicine, the Guyuan of reinforcing simultaneously, make gas, cloudy all that tonification is nourished, also can suppress the fast development of tumor, treating both the principal and secondary aspects of a disease, can long-term taking.
The foregoing is only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention and accompanying drawing content to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (7)
1. chemotherapy is auxiliary by a Chinese drug-treated group, it is characterized in that: comprise trichoderma pseudokoningii exocellular polysaccharide, the Radix Astragali, Radix Ginseng Rubra, Radix Angelicae Sinensis, Radix Ophiopogonis, Caulis Spatholobi, Semen Sesami, Rhizoma Dioscoreae, Plumula Nelumbinis, Radix Glycyrrhizae, Ganoderma, Herba Hedyotidis Diffusae.
2. Chinese medicine composition as claimed in claim 1, wherein, trichoderma pseudokoningii exocellular polysaccharide 0.5-1 part, 30 ~ 50 parts of the Radixs Astragali, 20 ~ 30 parts of Radix Ginseng Rubra, 20 ~ 30 parts of Radix Angelicae Sinensis, 5 ~ 15 parts of Radix Ophiopogonis, 8 ~ 12 parts of Caulis Spatholobis, Semen Sesami 10 ~ 20,5 ~ 10 parts of Rhizoma Dioscoreaes, 5 ~ 10 parts of Plumula Nelumbiniss, 5 ~ 10 parts, Radix Glycyrrhizae, 10 ~ 20 parts of Ganodermas, 8 ~ 12 parts of Herba Hedyotidis Diffusaes.
3. Chinese medicine composition as claimed in claim 1, wherein, trichoderma pseudokoningii exocellular polysaccharide 0.5-1 part, 30 ~ 50 parts of the Radixs Astragali, 20 ~ 30 parts of Radix Angelicae Sinensis, 5 ~ 15 parts of Radix Ophiopogonis, 5 ~ 10 parts of Rhizoma Dioscoreaes, 5 ~ 10 parts of Plumula Nelumbiniss, 5 ~ 10 parts, Radix Glycyrrhizae, 10 ~ 20 parts of Ganodermas, 8 ~ 12 parts of Herba Hedyotidis Diffusaes.
4. in claim 1, a kind of chemotherapy is auxiliary by the preparation process in Chinese drug-treated group, it is characterized in that: comprise the following steps:
(1) preparation method of cultivation trichoderma pseudokoningii exocellular polysaccharide:
A, trichoderma pseudokiningii is inoculated in after the activation of PDA culture medium, in flat board access fluid medium, at 28 ℃, under 120 rpm/min oscillating conditions, cultivate 10 days, with four layers of filtered through gauze fermentation liquid, remove after mycelia and spore, centrifugal, collect supernatant, be placed in Rotary Evaporators, 60 ℃ are evaporated to 1/3 of original volume, concentrated solution is entered to 95% ethanol hold over night of 3 ~ 4 times of volumes, 12000 rpm/min are centrifugal, collecting precipitation, precipitation is dissolved in to distilled water, centrifuging and taking supernatant, and D301-R type resin column decolouring excessively, collect eluent, then use Sevag method deproteinization, repeatedly until without protein, supernatant distillation is removed to organic solvent, after lyophilization, obtain crude extracellular polysaccharide sample,
B, crude polysaccharides is dissolved in to PH is in 8.2 Tris-HCl buffer, centrifugal, get DEAE Sepharose Fast Flow ion exchange column on supernatant, with carrying out gradient elution containing the Tris-HCl buffer of NaCl, automatically fraction collector is collected, and adopts phenolsulfuric acid method to merge and collects single peak district eluent, concentrating under reduced pressure postlyophilization, then further use Sephadex G-75 purification, obtain extracellular polysaccharide sterling;
(2) get Radix Ginseng Rubra, Radix Ophiopogonis, the Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, with twice of reflux, extract, in 30 ~ 40% ethanol, each 70 ~ 80 minutes, obtain ethanol extract for subsequent use, medicinal residues are decocted with water to 30min, concentrated filtrate, to the clear paste that relative density is 1.03 ~ 1.18, merge with ethanol extract, rotary evaporation reclaims ethanol, drying under reduced pressure, is crushed to fine powder for subsequent use;
(3) Semen Sesami, Rhizoma Dioscoreae, Plumula Nelumbinis, Ganoderma are ground to form to fine powder in mortar, mix with gained fine powder in step (2), carry out wet granulation, by the agent of granulator granulation, in incapsulating.
5. a kind of chemotherapy according to claim 4 is auxiliary is characterized in that by Chinese drug-treated group, and described in step (1) A, the component of PDA culture medium is Rhizoma Solani tuber osi 100g, glucose 20g, agar 20g, water 1000ml.
6. a kind of chemotherapy according to claim 4 is auxiliary is characterized in that by Chinese drug-treated group, and described in step (1) A, in Sevag method, adopting solvent is that the volume ratio of chloroform and n-butyl alcohol is 4:1.
7. a kind of chemotherapy according to claim 4 is auxiliary is characterized in that by Chinese drug-treated group, and while carrying out gradient elution in step (1) B, NaCl concentration range is 0-0.5 M.
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| CN201410096696.2A CN103816370A (en) | 2014-03-17 | 2014-03-17 | Chinese medicament group for assisting chemotherapy |
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| CN104286845A (en) * | 2014-09-17 | 2015-01-21 | 黄彩峰 | Traditional Chinese medicine medicated diet formula for postoperative nursing after chemotherapy, and preparation method thereof |
| CN107496645A (en) * | 2017-08-11 | 2017-12-22 | 防城港圣保堂制药有限公司 | A kind of ion Vc composition containing Chinese yam and preparation method thereof |
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| CN101152433A (en) * | 2007-09-15 | 2008-04-02 | 尹克华 | Traditional Chinese medicine for treating chemotherapy leukopenia after breast cancer operation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104286845A (en) * | 2014-09-17 | 2015-01-21 | 黄彩峰 | Traditional Chinese medicine medicated diet formula for postoperative nursing after chemotherapy, and preparation method thereof |
| CN107496645A (en) * | 2017-08-11 | 2017-12-22 | 防城港圣保堂制药有限公司 | A kind of ion Vc composition containing Chinese yam and preparation method thereof |
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Application publication date: 20140528 |