CN103816313B - A kind of pharmaceutical composition treating children's's pure hidrosis - Google Patents

A kind of pharmaceutical composition treating children's's pure hidrosis Download PDF

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CN103816313B
CN103816313B CN201410102898.3A CN201410102898A CN103816313B CN 103816313 B CN103816313 B CN 103816313B CN 201410102898 A CN201410102898 A CN 201410102898A CN 103816313 B CN103816313 B CN 103816313B
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parts
herb
root
hidrosis
pharmaceutical composition
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CN103816313A (en
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蒋桂荣
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Jiang Guirong
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The present invention relates to a kind of pharmaceutical composition treating children's's pure hidrosis, it is made up of following bulk drugs: suchow mosla herb, gratiola, conical silene herb, cypress vine pine, siphon, rhizoma atractylodis, evening primrose, cloves, delavay pararuellia herb, common elsholtzia herb, Semen Leonuri, caudate sweetleaf leaf, rhizoma alismatis, the root of kudzu vine, the red sage root, wild tea are peppery, the fruit of Chinese wolfberry, Fructus Corni, great burdock achene, wrinkled giant hyssop and the root of Dahurain angelica.The reasonable recipe of pharmaceutical composition for the treatment of children's's pure hidrosis of the present invention, have determined curative effect, safe ready, have no side effect, cheap feature.

Description

A kind of pharmaceutical composition treating children's's pure hidrosis
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of treat children's pure hidrosis Pharmaceutical composition.
Background technology
Hidrosis is the symptom that children's is common, and it can be a symptom of some disease, can also It is a simple symptom and without Other diseases.Children's's internal organs are tender and lovely, deiciency of primordial QI, the natural fibre line of meat Managing the closeest, sweating is more, easily has a cold and catches a cold.Night, sweating was more, causes agitation, sleeps Sleep uneasy, affect the life on daytime, study.
Children's is more weak due to physique, uses Western medicine to carry out treating often side effect bigger.And it is traditional Traditional Chinese medicine often uses the modes such as decoction decoction, oral tablet, capsule to produce, but After human gastrointestinal tract, its active ingredient may be substantially reduced.Therefore, for new formulation Exploitation is also in constantly research.
Navel, cave name Shenque, for the important acupuncture point of conception vessel, Gu have " Shenque, cures mainly all kinds of diseases and ailments, and Old man, empty people have loose bowels such as god " say, position, navel place be again chong channel in place of row, times superintend and direct two In arteries and veins table each other, commander's human body is all through hundred arteries and veins, therefore umbilical region is by above channels and collaterals and all internal organs of whole body Organ is maintained close ties with.Human body stomach wall is thin, and local application is prone to absorb, and no pain, is system The agents area that must further investigate.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition treating children's's pure hidrosis.
In order to realize the purpose of the present invention, the present invention provides a kind of and treats children's pure hidrosis Pharmaceutical composition, it is made up by weight of following bulk drugs: suchow mosla herb 20-50 part, Gratiola 25-40 part, conical silene herb 20-40 part, cypress vine pine 20-30 part, siphon 10-20 Part, rhizoma atractylodis 10-30 part, evening primrose 10-30 part, cloves 10-20 part, delavay pararuellia herb 10-20 Part, common elsholtzia herb 10-30 part, Semen Leonuri 10-20 part, caudate sweetleaf leaf 10-20 part, rhizoma alismatis 10-20 Part, root of kudzu vine 1-10 part, red sage root 5-15 part, wild tea peppery 5-15 part, fruit of Chinese wolfberry 1-5 part, mountain Fruit of medicinal cornel 1-5 part, great burdock achene 1-5 part, wrinkled giant hyssop 1-5 part and root of Dahurain angelica 1-5 part.
Preferably, of the present invention treatment children's's pure hidrosis pharmaceutical composition be by under Row raw material medicaments in part by weight meter is made: suchow mosla herb 32 parts, gratiola 28 parts, conical silene herb 30 Part, cypress vine pine 25 parts, siphon 15 parts, rhizoma atractylodis 20 parts, evening primrose 18 parts, cloves 18 parts, delavay pararuellia herb 16 parts, common elsholtzia herb 12 parts, Semen Leonuri 10 parts, caudate sweetleaf leaf 10 parts, Rhizoma alismatis 13 parts, the root of kudzu vine 8 parts, the red sage root 6 parts, wild peppery 6 parts of tea, the fruit of Chinese wolfberry 3 parts, mountain Zhu Cornel 2 parts, great burdock achene 1 part, wrinkled giant hyssop 2 parts and the root of Dahurain angelica 1 part.
It is highly preferred that described medicine can be tablet, dispersible tablet, disintegrated tablet, rapidly dissolving tablet, intestines Molten, navel patch or decoction.
It is highly preferred that described pharmaceutical composition is prepared by following method: take suchow mosla herb, Gratiola, conical silene herb, cypress vine pine, siphon, rhizoma atractylodis, evening primrose, cloves, delavay pararuellia herb, Common elsholtzia herb, Semen Leonuri, caudate sweetleaf leaf, rhizoma alismatis, the root of kudzu vine, the red sage root, wild tea are peppery, the fruit of Chinese wolfberry, mountain The fruit of medicinal cornel, great burdock achene, wrinkled giant hyssop and the root of Dahurain angelica, add 5 liters of water, heats 5 little under conditions of backflow Time, filter, obtain filter residue and filtrate 1；3 liters of water is added, under conditions of backflow in filter residue Heat 3 hours, filter, obtain filter residue and filtrate 2；Merging filtrate 1 and filtrate 2, be concentrated into Relative density 1.20 at 50 DEG C, EAT be 120 DEG C, infusion pump rotating speed be 20r/min Under conditions of be spray-dried, thus obtain dried powder, in above-mentioned powder, add wool 400 grams of fat, is stirred into paste, is coated on gas permeability sticker, uniformly cuts into 300 Sheet navel patch.
Have been accepted as " organic conception ", " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility use at present Medicine is such as used military forces " it is the most scientific maximally effective several big advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used Soldier " it is the original theory of traditional Chinese medicine of very science.In traditional Chinese medical science prescription, each medicine is as arrayed troops for battle Tight compatibility all linked with one another, is that it is better than the effective means that Western medicine is filled a prescription.Tcm prescription is theoretical Think that each prescription not only needs to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, Also should comply with the basic structure of prescription, i.e. the prescription compatibility reason of " monarch, minister, help, make " simultaneously Opinion, the prescription compatibility of so-called " monarch, minister, help, make ", it is simply that it is set up to the disease interpretation of the cause, onset and process of an illness Scientific matching on comprehensive judgement basis.In medical side by too many levels, Mutiple Targets integrate adjust The biological mechanism of joint, can obtain, more green natural more more longlasting than Western medicine and have no side effect Result for the treatment of, and this curative effect be built upon the above-mentioned traditional Chinese medical science tradition original theory accurate instruction it On, the present invention just have followed this principle.
In the composition of the present invention:
Suchow mosla herb (Classification system Mosla soochowensis Matsuda [Or-thodon Soochowensis (Matsuda) C.Y.Wu]) warm in nature, micro-pungent.Return lung channel；Stomach warp.Have Induce sweat, drive away summer heat, the effect such as regulating qi-flowing for relieving pain.([base] is Begoniaceae Begonia to gratiola The rhizome of plant Pharmacognostical Study, [former plant] Pharmacognostical Study Begonia pedatifida L é vl.) property put down, taste acid, there is the effects such as expelling wind and activating blood flow, Li Shui, removing toxic substances.Conical silene herb (draws Fourth formal name used at school Silene conoidea L.) sweet, micro-hardship, cool, return lung, Liver Channel, have yin-nourishing, The effects such as heat-clearing.Cypress vine pine (Classification system Quamoclit pennata (Lam.) Bojer) is sweet, Cold, there is the effects such as removing toxic substances, cool blood.Siphon (Classification system Vernonia cumingiana Benth.) pungent, heat, there is the effect such as promoting blood circulation to remove blood stasis, eliminating inflammation and expelling toxin.Rhizoma atractylodis: meridian distribution of property and flavor: Pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Curing mainly transporting imbalance, poor appetite, vomiting is unhappy, Abdominal distension is had loose bowels, arthralgia.Evening primrose (Classification system Oenothera biennis L.) taste is sweet； Bitter；Warm in nature, there is wines used as antirheumatic；The effects such as strengthening the bones and muscles.Cloves: taste is pungent warm in nature, Wen Zhongnuan kidney, Stopping nausea and vomiting by lowering the adverse flow of QI, mainly contains Eugenol etc., and its bud distills the volatile clove oil produced, tool There are special strong scent, energy antifungal activity pathogenic bacteria, and various pathogens had inhibitory action, Can treat for stomachache, warm up public region, except halitosis, toothache.Delavay pararuellia herb (Classification system Pararuellia Delauayana (Baill.) E.Hossain) sweet light, flat, have clearing heat and detoxicating, dissipate stagnation resolvation and swell Etc. effect.Common elsholtzia herb (Classification system Herba Elsholtziae Ciliatae) taste is pungent；Micro-hardship； Warm in nature, having dispels the wind delivers；Blood-arresting catamenia-regulating；The effects such as subdhing swelling and detoxicating.Semen Leonuri is pungent, bitter, It is slightly cold.The thoughts of returning home, Liver Channel.There is promoting blood circulation for regulating menstruation, the effect such as clear liver and improve vision.Caudate sweetleaf leaf (Latin Formal name used at school Symplocos sumuntia Buch.-Ham ex D Don S.Caudata Wall.], Leaf for Symplocaceae plant mountain alum) acid, puckery, micro-sweet, property is put down, and attaches to the lung and stomach meridians, and has clear The effect such as thermal detoxification, astringing to arrest bleeding.Rhizoma alismatis: taste is sweet, light, cold in nature.Return kidney；Bladder warp. There is effect for reducing blood fat.The root of kudzu vine: property gas is micro-, taste is micro-bitter.Deliver and bring down a fever, promote the production of body fluid to quench thirst. Cure mainly: table disease fever without perspiration, rigidity of nape and headache, pyreticosis is thirsty, quenches one's thirst, and macula is impermeable, insufficiency of the spleen Have loose bowels.To improving, the symptom effects such as headache, dizziness, Xiang Qiang, tinnitus, extremity numbness are preferable. The red sage root: Gui Jing: the popular feeling, Liver Channel.Function: promoting blood circulation and removing obstruction in channels, the detumescence of cool blood, relieving restlessness clears away heart-fire. Wild tea peppery (Classification system Cipedessa cinerascens(Pell.) Hand.Mazz. [C.fruticosa Bl.var.cinerascens Pell.；C.baccifera(Roth) Miq.var.sinenisWils.]) pungent； Bitter；Tepor, cures mainly dispel the wind dampness elimination, promoting qi circulation and relieving pain etc..The fruit of Chinese wolfberry: nature and flavor: cool in nature, taste is sweet. Function: relieve inflammation or internal heat, bring down a fever.Fructus Corni: tonify the liver and kidney, puckery essence takes off admittedly.For dizziness tinnitus, Under soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, uterine bleeding band, profuse sweating is collapsed, interior heat is quenched one's thirst. Great burdock achene: pungent, bitter, cold.Enter lung, stomach warp.There is dispelling wind and heat from the body, profit pharynx dissipating bind, removing toxic substances The effects such as promoting eruption.Wrinkled giant hyssop: taste is pungent；Slightly warm in nature.Fruit can make spices, leaf and stem all rich in volatilization Property aromatic oil, has strong fragrance, for aromatic oil raw material.The root of Dahurain angelica: taste is pungent warm in nature, has anti- Bacterium, detumescence, analgesic efficacy, can treat have a toothache, rhinitis, disease of skin, and skin of moistening, Fragrance pain nine orifices, flat enter blood, pass through inside on reach, fragrance pleasant.
For the composition of the present invention, according to the prescription compatibility theory of " monarch, minister, help, make ", Suchow mosla herb, gratiola, conical silene herb, cypress vine pine are monarch drug in a prescription；Siphon, rhizoma atractylodis, evening primrose, Cloves, delavay pararuellia herb are ministerial drug；Common elsholtzia herb, Semen Leonuri, caudate sweetleaf leaf, rhizoma alismatis, the root of kudzu vine are adjutant； The red sage root, wild tea are peppery, the fruit of Chinese wolfberry, Fructus Corni, great burdock achene, wrinkled giant hyssop and the root of Dahurain angelica be for making medicine.At this In invention, all medicines are harmonious, reasonable recipe, have determined curative effect, safe ready, have no side effect, Cheap feature.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that the reality of the present invention Executing example is for illustrating rather than limitation of the present invention.Essence pair according to the present invention The simple modifications that the present invention is carried out broadly falls into the scope of protection of present invention.Unless otherwise saying Bright, otherwise the percentage in the present invention is percetage by weight.
The patch of the embodiment present invention
Take suchow mosla herb 320 grams, gratiola 280 grams, conical silene herb 300 grams, cypress vine pine 250 grams, Siphon 150 grams, rhizoma atractylodis 200 grams, evening primrose 180 grams, cloves 180 grams, delavay pararuellia herb 160 grams, common elsholtzia herb 120 grams, Semen Leonuri 100 grams, caudate sweetleaf leaf 100 grams, rhizoma alismatis 130 grams, The root of kudzu vine 80 grams, the red sage root 60 grams, wild peppery 60 grams of tea, the fruit of Chinese wolfberry 30 grams, Fructus Corni 20 grams, Great burdock achene 10 grams, wrinkled giant hyssop 20 grams and the root of Dahurain angelica 10 grams, add 5 liters of water, in the condition of backflow Lower heating 5 hours, filters, obtains filter residue and filtrate 1；In filter residue, add 3 liters of water, returning Heat 3 hours under conditions of stream, filter, obtain filter residue and filtrate 2；Merging filtrate 1 and filtrate 2, it is concentrated into relative density 1.20 at 50 DEG C, uses ZLPG6-10 spray dryer (Jiangsu Fan Qun drying equipment factory) EAT be 120 DEG C, infusion pump rotating speed be the bar of 20r/min It is spray-dried under part, thus obtains dried powder, in above-mentioned powder, add lanolin 400 grams, it is stirred into paste, is coated on gas permeability sticker, uniformly cuts into 300 Navel patch.
Pharmacology pharmacodynamic is reported
Acute toxicity test is reported
Animal used as test: Kunming mouse, female 12, male 12, body weight 18～22g, Purchased from Shanghai Slac Experimental Animal Co., Ltd..
Trial drug: take suchow mosla herb 320 grams, gratiola 280 grams, conical silene herb 300 grams, creeping plant Trailing plants pine 250 grams, siphon 150 grams, rhizoma atractylodis 200 grams, evening primrose 180 grams, cloves 180 Gram, delavay pararuellia herb 160 grams, common elsholtzia herb 120 grams, Semen Leonuri 100 grams, caudate sweetleaf leaf 100 grams, Rhizoma alismatis 130 grams, the root of kudzu vine 80 grams, the red sage root 60 grams, wild peppery 60 grams of tea, the fruit of Chinese wolfberry 30 grams, Fructus Corni 20 grams, great burdock achene 10 grams, wrinkled giant hyssop 20 grams and the root of Dahurain angelica 10 grams, add 5 liters of water, Heat 5 hours under conditions of backflow, filter, obtain filter residue and filtrate 1；Add in filter residue 3 liters of water, heats 3 hours under conditions of backflow, filters, obtains filter residue and filtrate 2；Merge Filtrate 1 and filtrate 2, regulation concentration is to being equivalent to 1.5g crude drug/ml.
Experimental procedure:
1. mouse adaptability is fed 3～4 days, and body weight control is within 22g
2. before mouse is administered, water 12h is can't help in fasting；
3. packet, is assigned to mouse in blank group and administration group with random digits table, often Organize 12, male and female half and half.
4. being administered, blank group gives physiological saline, and administration group gives the liquid of preparation, gavage Amount 0.25ml/10g.One day twice.
Experimental result: after gavage, mouse activity reduces, anorexia, after 24 hours, by Gradually recover.After 48 hours, the most normally.Feeding continuously 1 week, not abnormal occur.Not The phenomenon of dead mouse, general mortality rate 0 occur.According to the experience of Chinese medicine studies on acute toxicity, It is believed that medicament of the present invention is safe.
Long term toxicity test is reported
Animal used as test: SD big white mouse, body weight is at 120-130g, and male and female half and half, purchased from Shanghai This Rec animal used as test Co., Ltd.
Trial drug: use the liquid of preparation in anxious poison test.
Experimental procedure: take big white mouse 20, is divided into 2 groups, often group 10, and wherein the 1st Group, as administration group, is fed by filling for 2 times every every day, each 6ml, and the 2nd group of diet is made For control group (the most not giving any drug therapy, the most normally raise), once a day, Fill continuously and feed 90 days, survey body weight, be administered latter 24 hours sacrificed by decapitation in last, survey blood, Routine urinalysis, liver function, renal function, core, the internal organ such as kidney, the change of tissues observed form, Observing the effect of dosage, observe diet, movable change, experiment proves administration group and control group Relatively without notable change, show that medicament of the present invention is safe.
Clinical testing
100 examples are out-patient, are divided into two groups, wherein treatment group 50 example, male 25 examples, Female 25 example；1～3 years old 18 example, 3～7 years old 15 example, 7～14 years old 17 example；Only many after activity Sweat 12 example, hidrosis 6 example time quiet, hidrosis at night 50 example.Control group 50 example, male 25 examples, Female 25 example；1～3 years old 16 example, 3～7 years old 20 example, 7～14 years old 14 example；Only many after activity Sweat 14 example, hidrosis 6 example time quiet, hidrosis at night 49 example.Case load between two groups, the age, Sex, the state of an illness are all without significant difference (P > 0.05).All cases all get rid of other febrile diseases, The disease such as rickets, tuberculosis, in addition to hidrosis, ordinary circumstance is good, and blood, routine urinalysis are normal, blood calcium, Phosphorus, magnesium are normal.
Control group OP Themgran Junior drops (Shanghai Shi Guibao pharmaceutical Co. Ltd of Sino-U.S. Produce), once-a-day, each 1 milliliter, treat 3 days.
Treatment group uses the patch of preparation in embodiment, once a day, is pasted by a piece of patch every time Invest on the navel of patient, treat 3 days.
Curative effect determinate standard
Cure: after 1 course for the treatment of, symptom is wholly absent, follow up a case by regular visits to 1 month without recurrence.Effective: 2 treatments After journey, hidrosis is obviously improved, without the most frightened, DOMS.Invalid: symptom is without improving.
Result
Through treatment, the treatment results of two groups see table:
Group Number of cases Cure Effectively Invalid Total effective rate (%)
Treatment group 50 46 4 0 100
Control group 50 1 7 42 16
Model case
Zhang, man, 5 years old, sweat all over during activity at ordinary times, under sweat such as beans, relatively other children Perspiration is many, to our hospital on March 3rd, 2013, uses the patch of preparation in embodiment, Once a day, a piece of patch is attached on the navel of patient every time, treats 3 days.And play Companion sweats all over when playing, transference cure under sweat such as beans.Follow up a case by regular visits to 1 month without recurrence.
King so-and-so, female, 5 years old, night perspired serious, and vest and bed clothes are drenched, Jia Changpai Except factors such as in room temperature, temperature are too high, the quilt of lid of sleeping is too much.On May 15th, 2013 To our hospital, use the patch of preparation in embodiment, once a day, every time by a piece of patch It is attached on the navel of patient, treats 3 days.Sleep under normal condition serious showing of not perspiring As.Follow up a case by regular visits to 1 month without recurrence.
Close so-and-so, female, 6 years old, continuous perspiration when being seated of attending class at ordinary times, drenched clothes.In 2013 On June 21, in is to our hospital, uses the patch of preparation in embodiment, once a day, often Secondary a piece of patch is attached on the navel of patient, treats 3 days.Do not have under the conditions of normally sitting quietly Perspire serious phenomenon.Follow up a case by regular visits to 1 month without recurrence.

Claims (2)

1. the pharmaceutical composition treating children's's pure hidrosis, it is characterised in that it be by Following bulk drugs is made by weight: suchow mosla herb 20-50 part, gratiola 25-40 part, wheat Bottle grass 20-40 part, cypress vine pine 20-30 part, siphon 10-20 part, rhizoma atractylodis 10-30 part, Evening primrose 10-30 part, cloves 10-20 part, delavay pararuellia herb 10-20 part, common elsholtzia herb 10-30 part, Semen Leonuri 10-20 part, caudate sweetleaf leaf 10-20 part, rhizoma alismatis 10-20 part, root of kudzu vine 1-10 part, pellet Ginseng 5-15 part, wild tea peppery 5-15 part, fruit of Chinese wolfberry 1-5 part, Fructus Corni 1-5 part, great burdock achene 1-5 part, wrinkled giant hyssop 1-5 part and root of Dahurain angelica 1-5 part.
The pharmaceutical composition for the treatment of children's's pure hidrosis the most according to claim 1, its Being characterised by, it is made up by weight of following bulk drugs: suchow mosla herb 32 parts, water eight 28 parts of angle, conical silene herb 30 parts, cypress vine pine 25 parts, siphon 15 parts, rhizoma atractylodis 20 parts, Evening primrose 18 parts, cloves 18 parts, delavay pararuellia herb 16 parts, common elsholtzia herb 12 parts, Semen Leonuri 10 Part, caudate sweetleaf leaf 10 parts, rhizoma alismatis 13 parts, the root of kudzu vine 8 parts, the red sage root 6 parts, wild peppery 6 parts of tea, The fruit of Chinese wolfberry 3 parts, Fructus Corni 2 parts, great burdock achene 1 part, wrinkled giant hyssop 2 parts and the root of Dahurain angelica 1 part.
CN201410102898.3A 2014-03-19 2014-03-19 A kind of pharmaceutical composition treating children's's pure hidrosis Expired - Fee Related CN103816313B (en)

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