CN103816083B - A kind of pox-dispelling function transparency emulsion containing basic fibroblast growth factor and preparation method thereof - Google Patents
A kind of pox-dispelling function transparency emulsion containing basic fibroblast growth factor and preparation method thereof Download PDFInfo
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- CN103816083B CN103816083B CN201410073098.3A CN201410073098A CN103816083B CN 103816083 B CN103816083 B CN 103816083B CN 201410073098 A CN201410073098 A CN 201410073098A CN 103816083 B CN103816083 B CN 103816083B
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Abstract
The invention discloses a kind of pox-dispelling function transparency emulsion containing basic fibroblast growth factor and preparation method thereof.The composition of the present invention includes: basic fibroblast growth factor, tea tree ethereal oil, azelaic acid, vitamin, emollient, NMF, surfactant, phosphate buffer and deionized water.The basic fibroblast growth factor that the present invention contains can have the growth of efficient recovery subcutaneous connective tissue, improves microcirculation, dispels acne print；Tea tree ethereal oil and azelaic acid all have effect of inhibiting bacteria and diminishing inflammation, and synergy can be with high efficiency anti-inflammatory anti-acne；Moistness is good, non-stimulated to skin.
Description
Technical field
The present invention relates to pox-dispelling function print emulsion, be specifically related to a kind of anti-acne containing basic fibroblast growth factor
Except print transparency emulsion and preparation method thereof.
Background technology
Small pox is also called acne, acne, be chronic inflammation hair follicle sebum gland disease, be the modal disease of dept. of dermatology it
One.Small pox is the worried problem of many people, and physiological health is not only had an impact by it, and to the psychology of people and social influence very
Greatly, especially bigger on pursuing beautiful women impact.Simultaneously most of small poxs all can stay acne to print, if treating meeting not in time
Stay permanent acne to print, more affect attractive in appearance.Although existing commercially available anti-acne anti-acne print product category is a lot, but effect is all not clear
Aobvious.
Small pox is owing to, caused by hair follicle and sebaceous glands obstruction, inflammation, practising with the sleep of psychology, physiology, environment and diet
It is used to wait many factors relevant.Anti-acne have main steps that suppression skin oil and fat secretion, eliminate simultaneously due to fat secretion too much and
The bacterial micro-organisms causing etc. grow and induce scytitis etc..
The generation of acne print is due to the office of the effect of microorganism and small pox induction in follicular keratosis transition, pilosebaceous unit
The scar that portion's inflammation makes the skin corium of skin receive damage and stays.Long acne on general skin, majority can be unable to bear using hand
Go to rack small pox, so can increase the weight of the formation of acne print.Dispel acne print and most importantly promote skin microcirculation, accelerate the new of skin
Old metabolism, promotes the generation of collagen and elastomer, thus desalination or thoroughly elimination acne prints.
Content of the invention
Present invention aims to the deficiencies in the prior art, provide one to contain basic fibroblast growth factor
(bFGF) pox-dispelling function transparency emulsion and preparation method thereof.The basic fibroblast growth containing in the emulsion of the present invention because of
Son is the protein that a kind of peptide bond is constituted, and for the basic protein containing 155 amino acid, the damage to internal various tissues has bright
Aobvious repair.The physiology to skin for the bFGF has multiple biological function: can improve skin microcirculation, changes the various cell of skin
The metabolism of tissue, has the growth of efficient recovery subcutaneous connective tissue, so that skin smooth is delicate, and high resilience, eliminate acne print.Tea
Tree essential oil is very strong to general bacterium, mould, saccharomycetic sterilizing power, is the extraction component of a kind of Nantural non-toxic, azelaic acid
It is the active ingredient suppressing whelk inflammation in dept. of dermatology, have good anti-acne effect with tea tree ethereal oil synergy.
It is an object of the invention to be achieved by below scheme:
A kind of pox-dispelling function transparency emulsion containing basic fibroblast growth factor, it is characterised in that dispelling with 100ml
Acne is except print transparency emulsion meter, and its formula is as follows:
In above-mentioned transparency emulsion, described basic fibroblast growth factor is human alkaline fibroblast growth factor
bFGF。
In above-mentioned transparency emulsion, described emollient is isopropyl myristate, olive oil, jojoba oil, caryophyllus oil, almond
Oil, coconut oil, laruyl alcohol phosphate amine salt, tea-seed oil, avocado oil, saualane, diethylhexyl hexamethylene, sher butter, palm fibre
Palmitic acid acid Octyl Nitrite, isopropyl palmitate, ermine oil, wheat-germ oil, sunflower seeds oleic acid, isononyl isononanoate, PEG-7 glycerine coconut palm
Oleate, PEG-26 oleate, dioctyl succinate, silicone oil, cetyl stearate, the different pelargonate of cetanol, carbonic acid dibutyl ester,
Cetanol palmitate, Permethyl 99A, isohexadecane, C12～C15 alcohol benzoic ether, polymethyl acid glyceride, poly-hydroxyl
One or more in stearate, pentaerythritol tetraoctyl stearate, myristyl myristate ester or octyl palmitate.
In above-mentioned transparency emulsion, described vitamin is one or more in VitAVitE or pantothenic acid.
In above-mentioned transparency emulsion, described NMF be glycerine, propane diols, PEG-400, ethanol, ethylene glycol monomethyl ether or
One or more in polyglyceryl fatty acid ester.
In above-mentioned transparency emulsion, described surfactant is Cremophor RH 40, soybean lecithin, alkyl
One or more in glucose glucosides, Tweens or spans.
A kind of preparation method of the pox-dispelling function transparency emulsion containing basic fibroblast growth factor, including following step
Rapid:
(1) stirring under tea tree ethereal oil, emollient and vitamin normal temperature is mixed to form oil phase substrate solution A；With deionization
Water is as aqueous phase；
(2) azelaic acid is dissolved in above-mentioned oil phase substrate solution A, obtains oil phase substrate solution B；
(3) it is dissolved in basic fibroblast growth factor in phosphate buffer, with NMF and surfactant together
Add in the oil phase substrate solution B of step (2) gained, stir under normal temperature；
(4) being added dropwise over deionized water to the total emulsion volume described in above-mentioned steps (1) is 100ml, with 600～
The speed stirring of 1000rmp forms transparency emulsion, continues stirring 8～12h, obtains dispelling containing basic fibroblast growth factor
Acne is except print transparency emulsion.
Compared with prior art, present invention have the advantage that
(1) emulsion of the present invention contains basic fibroblast growth factor and can improve skin microcirculation, changes skin
The metabolism of various cell tissues, has the growth of efficient recovery subcutaneous connective tissue, so that skin smooth is delicate, and high resilience, disappear
Except acne print.
(2) to contain sterilizing extraction component tea tree ethereal oil, azelaic acid and the basic fibroblast of Nantural non-toxic thin for emulsion of the present invention
The intracellular growth factor, three acts synergistically, and eliminates the microorganism on skin and inflammation well, dispels small pox and acne print.
(3) emulsion of the present invention also has emollient, NMF and vitamin, can well give skin while pox-dispelling function
Keep the skin wet and nutrition, skin care.
(4) emulsion of the present invention is highly stable, is beneficial to long-term preservation.
(5) preparation method of the present invention is simple, and equipment is simple, and production cost is low.
Detailed description of the invention
It below in conjunction with embodiment, is further explained explanation to embodiments of the present invention, but protection scope of the present invention
It is not limited to this.The basic fibroblast growth factor below using is human alkaline fibroblast growth factor bFGF.
Embodiment 1
The pox-dispelling function transparency emulsion composition of raw materials of the present embodiment specifically includes following each component:
1) by the formula of above-mentioned pox-dispelling function transparency emulsion, by normal to tea tree ethereal oil, isopropyl myristate and vitamin E
The lower stirring of temperature is mixed to form oil phase substrate solution, using deionized water as aqueous phase；
2) azelaic acid is dissolved in above-mentioned oil phase substrate solution；
3) it is dissolved in basic fibroblast growth factor in phosphate buffer, together add with propane diols and Tween-80
In the oil phase of step (2), stir under normal temperature；
4) being dropwise slowly added to deionized water to total emulsion volume in step (3) is 100ml, stirs with the speed of 800rmp
Mix formation transparency emulsion, continue stirring 12h, prepare the pox-dispelling function transparency emulsion containing basic fibroblast growth factor.
Embodiment 2
The pox-dispelling function transparency emulsion of the present embodiment, this emulsion is as follows except each amounts of components in composition of raw materials
Outward, remaining is with embodiment 1:
Embodiment 3
The pox-dispelling function transparency emulsion of the present embodiment, this emulsion is as follows except each amounts of components in composition of raw materials
Outward, remaining is with embodiment 1:
Embodiment 4
The pox-dispelling function transparency emulsion of the present embodiment, this emulsion is as follows except each amounts of components in composition of raw materials
Outward, remaining is with embodiment 1:
Embodiment 5 stability experiment
The pox-dispelling function transparency emulsion of embodiment 1～4 is taken 5ml respectively and is placed in centrifuge, be 10000r/min at rotating speed
Under the conditions of centrifugal 5min, be showed no transparency emulsion layering or muddy.
The pox-dispelling function transparency emulsion of embodiment 1～4 is divided into 3 parts, and every part of 5ml is put in the vial of sealing, respectively
Be placed at 4 DEG C, 25 DEG C and 40 DEG C placement half a year, midway at any time sampling observe, all keep pellucidity, have no layering or muddiness go out
Existing.
Embodiment 6 pox-dispelling function effect assessment is tested
Evaluated the pox-dispelling function effect of the pox-dispelling function transparency emulsion of embodiment 1～4 by Practical Experiment.Use and implement
The pox-dispelling function transparency emulsion of example 1 preparation, the pox-dispelling function transparency emulsion of embodiment 2 preparation, the pox-dispelling function of embodiment 3 preparation
Transparency emulsion, embodiment 4 preparation pox-dispelling function transparency emulsion and be not added with basic fibroblast growth factor, tea tree ethereal oil
With the blank emulsion (control group) of azelaic acid, totally five laboratory groups.
Choosing the people totally 50 of the long acne of the skin between 18～25 years old, at random they being divided into five groups, every day is sooner or later clean
After skin, above-mentioned five laboratory groups of uniform application respectively on their face's small pox position and surrounding skin, continuous one week, use meat
Eye observes the effect of pox-dispelling function.Result performance is as shown in table 1.
Table 1 pox-dispelling function evaluation effect
| Effectively | Somewhat effective | Invalid | Efficient (%) | |
| Embodiment 1 pox-dispelling function transparency emulsion | 7 | 1 | 2 | 80 |
| Embodiment 2 pox-dispelling function transparency emulsion | 6 | 3 | 1 | 90 |
| Embodiment 3 pox-dispelling function transparency emulsion | 7 | 2 | 1 | 90 |
| Embodiment 4 pox-dispelling function transparency emulsion | 8 | 1 | 1 | 90 |
| Control group | 1 | 1 | 8 | 20 |
From the Comparative result of table 1 it can be seen that the anti-acne of the present invention removes acne except acne print transparency emulsion has good anti-acne
Print effect, and, the skin to this 50 observers for the emulsion of the present invention has the effect of moistening and does not all occur that excitant is existing
As.
Embodiment 7
Preparation does not contains the transparency emulsion of tea tree ethereal oil, the transparency emulsion without azelaic acid, does not contains basic fibroblast life
The transparency emulsion of the long factor.The preparation method of above-mentioned three kinds of emulsions is all same as in Example 4, is simply added without tie substance.
Choosing the people totally 40 of the long acne of the skin between 18～25 years old, at random they being divided into four groups, every day is sooner or later clean
After skin, uniform application aforementioned four laboratory group respectively on their face's small pox position and surrounding skin, continuous one week, use meat
Eye observes the effect of pox-dispelling function.Result performance is as shown in table 2.
Table 2 pox-dispelling function evaluation effect
From the results shown in Table 2, the transparency emulsion of gained of the present invention is compared to lacking tea tree ethereal oil, azelaic acid or alkali
Property fibroblast growth factor transparency emulsion anti-acne except acne print effect obvious, it is seen then that in the transparency emulsion of gained of the present invention
The synergy of tea tree ethereal oil, azelaic acid and basic fibroblast growth factor is obvious.
Claims (2)
1. the pox-dispelling function transparency emulsion containing basic fibroblast growth factor, it is characterised in that with the anti-acne of 100ml
Except print transparency emulsion meter, its formula is as follows:
Basic fibroblast growth factor 0.05 ~ 100 μ g；
Emollient 1 ~ 10g；
Vitamin 0.1 ~ 2g；
Tea tree ethereal oil 0.25 ~ 0.5g；
Azelaic acid 0.25 ~ 0.5g；
NMF 3 ~ 15g；
Surfactant 3 ~ 15g；
Phosphate buffer 0.5 ~ 1g；
Remaining is deionized water；
Described basic fibroblast growth factor is human alkaline fibroblast growth factor bFGF；Described emollient is Pork and beans
Cool isopropyl propionate, olive oil, jojoba oil, caryophyllus oil, apricot kernel oil, coconut oil, laruyl alcohol phosphate amine salt, tea-seed oil, avocado
Oil, saualane, diethylhexyl hexamethylene, sher butter, ethylhexyl palmitate, isopropyl palmitate, ermine oil, wheat embryo
Oil, sunflower seeds oleic acid, isononyl isononanoate, PEG-7 glyceryl cocoate, PEG-26 oleate, dioctyl succinate, silicone oil,
The different pelargonate of cetyl stearate, cetanol, carbonic acid dibutyl ester, cetanol palmitate, Permethyl 99A, isohexadecane, C12 ~
C15 alcohol benzoic ether, polymethyl acid glyceride, poly-hydroxy stearic acid ester, pentaerythritol tetraoctyl stearate, myristic acid
One or more in tetradecane ester or octyl palmitate；Described vitamin is in VitAVitE or pantothenic acid
One or more；
Described NMF is in glycerine, propane diols, PEG-400, ethanol, ethylene glycol monomethyl ether or polyglyceryl fatty acid ester
Plant or two or more；Described surfactant be Cremophor RH 40, soybean lecithin, alkyl glucosides glucosides,
One or more in Tweens or spans.
2. the preparation side of a kind of pox-dispelling function transparency emulsion containing basic fibroblast growth factor described in claim 1
Method, it is characterised in that comprise the following steps:
(1) stirring under tea tree ethereal oil, emollient and vitamin normal temperature is mixed to form oil phase substrate solution A；Make with deionized water
For aqueous phase；
(2) azelaic acid is dissolved in above-mentioned oil phase substrate solution A, obtains oil phase substrate solution B；
(3) it is dissolved in basic fibroblast growth factor in phosphate buffer, together add with NMF and surfactant
In the oil phase substrate solution B of step (2) gained, stir under normal temperature；(4) it is added dropwise over going described in above-mentioned steps (1)
Ionized water to total emulsion volume is 100ml, forms transparency emulsion with the speed stirring of 600 ~ 1000rmp, continues stirring 8 ~ 12h,
Obtain the pox-dispelling function transparency emulsion containing basic fibroblast growth factor.
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| CN107281033A (en) * | 2017-07-03 | 2017-10-24 | 李剑峰 | Sleep mask of acne scar acne print and its preparation method and application can be repaired |
| CN108451797A (en) * | 2018-02-02 | 2018-08-28 | 广州赛莱拉干细胞科技股份有限公司 | Include the composition of red autumnal leaves algae extract |
| CN108578265A (en) * | 2018-07-04 | 2018-09-28 | 广州领衔生物科技有限公司 | Maintenance stoste and its preparation method and application |
| CN112972310A (en) * | 2021-03-23 | 2021-06-18 | 青岛智博生物科技有限公司 | Composition with antibacterial and repairing effects and preparation method thereof |
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Effective date of registration: 20211222 Address after: 510663 No. a401, 403 and 405, zone a, Guangzhou International Business Incubator, No. 3, Juquan Road, Science City, Huangpu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Zhiyuan Biotechnology Co.,Ltd. Address before: 510640 No. five, 381 mountain road, Guangzhou, Guangdong, Tianhe District Patentee before: SOUTH CHINA University OF TECHNOLOGY |