CN103800760B - 一种治疗颈椎炎、风湿关节炎的中药 - Google Patents
一种治疗颈椎炎、风湿关节炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗颈椎炎、风湿关节炎的中药，由以下重量配比的药材制备而成：小叶爬岩香10份、鸡树条3份、榕须3份、四念癀1份、半枫荷根1份、铁丝灵仙2份、岩陀1份、艾虎15份、小叶买麻藤0.5份、搜山虎6份、鸭儿芹1份、马尾千金草3份、井口边草20份、长管假茉莉4份、朝鲜当归10份、追风伞1份、柔毛水杨梅2份、葫芦藓30份、钻地风5份、大透骨草3份、红毛走马胎3份、南蛇藤根1份、绵萆薢15份、丁公藤6份、积雪草17份。临床实验证明，本发明能够安全有效治疗颈椎炎、风湿关节炎。
Description
技术领域
本发明涉及一种中药，尤其是涉及一种治疗颈椎炎、风湿关节炎的中药。
背景技术
颈椎炎是泛指颈段脊柱病变后所表现的临床症状和体征。是一种多发病，在40-60岁为高发年龄，70岁以后发病率为100%。但现在已经在逐步年轻化发展。颈椎病的发生与颈椎的急慢性损伤、职业特点及个人的体质包括遗传特质有密切的关系，此外个人的生活习惯及饮食习惯有着一定的影响。颈椎炎的治疗是一个综合性的治疗过程，日常的保护预防非常重要。
风湿病是一组侵犯关节、骨骼、肌肉、血管及有关软组织或结缔组织为主的疾病，其中多数为自身免疫性疾病。发病多较隐蔽而缓慢，病程较长，且大多具有遗传倾向。诊断及治疗均有一定难度；血液中多可检查出不同的自身抗体，可能与不同HLA亚型有关；对非甾类抗炎药(NSAID)，糖皮质激素和免疫抑制剂有较好的短期或长期的缓解性反应。
类风湿关节炎（RA）是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病。其特征是手、足小关节的多关节、对称性、侵袭性关节炎症，经常伴有关节外器官受累及血清类风湿因子阳性，可以导致关节畸形及功能丧失。
对于颈椎炎、风湿关节炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
小叶爬岩香
【来源】药材基源：为胡椒科植物小叶爬岩香全株。
【性味】辛；微湿
【功能主治】祛风除湿；散寒止痛；活血舒筋。主风寒湿痹；脘腹冷痛；扭挫伤；牙痛；风疹
【用法用量】内服：煎汤，10-20g;或浸酒。外用：适量，捣烂酒调敷。
鸡树条
【来源】忍冬科荚蒾属植物天目琼花ViburnumsargentiiKoehne，以嫩枝、叶及果实入药。
【性味】甘、苦，平。
【功能主治】叶、枝：通经活络，解毒止痒。
枝：用于风湿性关节炎，腰酸腿痛，跌打损伤。
叶：外用治疮疖，癣，皮肤搔痒。
果：止咳。用于急、慢性气管炎，咳嗽。
【用法用量】枝3～4钱，果2～3钱，叶外用适量，捣烂敷或煎水洗患处。
榕须
【来源】为桑科植物榕树的气根。
【性味】苦涩，平。
【功能主治】祛风清热，活血解毒。治流感，百日咳，麻疹不透，扁桃体炎，眼结膜炎，痧气腹痛，风湿骨痛，鼻衄，血淋，跌打损伤。
【用法用量】内服：煎汤，3～5钱；或浸酒。外用：捣碎酒炒敷或煎水洗。
四念癀
【来源】报春花科四念癀AnagallisarvensisL.var.coerulea（Schreb.）Gren.etGodr.，以全草入药。
【生境分布】福建、台湾及华南沿海。
【性味】苦、酸，温。
【功能主治】祛风通络，化腐生肌。用于鹤膝风；外用治疮疡，阴症。
【用法用量】鲜草1两，青壳鸭蛋1枚，酒水各半炖服。外用全草捣烂外敷。
半枫荷根
【来源】为梧桐科植物翻白叶树的根。全年可采，切片，晒干。
【性状】干燥根常切为厚约3毫米的饮片，栓皮浅棕色，木心浅红棕色。质略松，易碎。
【性味】广州部队《常用中草药手册》："甘淡，微温。"
【功能主治】祛风除湿，活血消肿。治风湿痹痛，腰肌劳损，手足酸麻无力，跌打损伤。
【用法用量】内服：煎汤，0.5～1两；或浸酒。
铁丝灵仙
【来源】百合科菝葜属植物黑刺菝葜SmilaxscobinicaulisC.H.Wright或粘鱼须SsieboldiMiq.，以根状茎及根入药。四季可采，除去茎、叶和泥土，晒干。
【性味】辛，温。
【功能主治】祛风湿，通经络。用于风湿性关节炎，关节不利。
【用法用量】1～3钱。
岩陀
【来源】为虎耳草科植物西南鬼灯檠的根茎。秋、冬采挖，洗净切片晒干。
同属植物羽状鬼灯檠亦同供药用。
【性味】苦微涩。凉。
《云南中草药选》："苦涩，凉。"
【功能主治】活血调经，祛风湿。治跌打，骨折，月经不调，风湿性关节炎，刀伤出血。
【用法用量】内服：煎汤，0.5～1两；或浸酒。外用：研末撒或研末调敷。
艾虎
【来源】药材基源：为鼬科动物艾鼬的肉。
【性味】味甘；性温
【归经】心；肝经
【功能主治】祛风；镇痉；活血通络。主癫痫；瘫痪；半身不遂
【用法用量】内服：煎汤，9-15g。
小叶买麻藤
【来源】为买麻藤科买麻藤属植物小叶买麻藤Gnetumparvifolium（Warb.）C.Y.Cheng以藤、根和叶入药。
【性味】苦，微温。
【功能主治】祛风活血，消肿止痛，化痰止咳。用于风湿性关节炎，腰肌劳损，筋骨酸软，跌打损伤，支气管炎，溃疡出血，蛇咬伤；外用治骨折。
【用法用量】0.5～1两；外用适量，鲜品捣烂热敷患处。
搜山虎
【来源】为茄科植物新莨菪的根。秋冬采收，洗净；切片晒干。
【性味】辛苦，温，剧毒。
【功能主治】祛风解表；行气活血；消肿止痛。主风寒感冒；风湿痹痛；龋齿痛；跌打肿痛；骨折；毒蛇咬伤
【用法用量】内服：煎汤，2-6g；或浸酒。外用：适量，浸酒搽，或研末酒调敷。
鸭儿芹
【来源】为伞形科植物鸭儿芹的茎叶。
【性味】辛苦，平。
【功能主治】消炎，解毒，活血，消肿。治肺炎，肺脓肿，淋病，疝气，风火牙痛，痈疽疔肿，带状疱疹，皮肤瘙痒。
【用法用量】内服：煎汤，0.5～1两。外用：捣敷或研末撒。
马尾千金草
【来源】为石松科植物马尾千金草的全草。全年可采。
【性味】《广西中药志》："平，淡。"
【功能主治】舒筋，活络，祛风湿。治跌打损伤，肌肉痉挛，筋骨疼痛。
【用法用量】内服：煎汤，1～3钱；或浸酒服。
井口边草
【来源】为风尾蕨科植物亮凤尾蕨的全草。全年可采，洗净晒干。
【性味】甘；淡；凉
【归经】肝；大肠经
【功能主治】清热利湿；止血生肌；解毒消肿。主泄泻；痢疾；黄疸；淋证；水肿；咳血；尿血；便血；刀伤出血；跌打肿痛；疮痈；水火烫伤
【用法用量】内服：煎汤，10-30g。外用：适量，研末撒；煎水洗；或鲜品捣敷。
长管假茉莉
【来源】药材基源：为伞形科植物朝鲜当归的根。
【来源】为马鞭草科植物长管假茉莉的全草。全年可采。
【性味】性凉，味苦。
【功能主治】消炎利尿，活血消肿，祛风湿。治尿路感染，膀胱炎，跌打扭伤，风湿骨痛。
【用法用量】内服：煎汤，3～5钱。外用：捣敷。
朝鲜当归
【来源】药材基源：为伞形科植物朝鲜当归的根。
【性味】味辛；性温
【功能主治】祛风通络；活血止痛。主风湿痹痛；跌打肿痛
【用法用量】内服：煎汤，10-15g。外用：适量，煎汤洗。
追风伞
【来源】为报春花科植物狭叶排草的根或全草。
【性味】①《贵阳民间药草》："辛，温，无毒。"②《贵州草药》："性温，味苦辛。"
【功能主治】祛风，活血。治风湿痹痛，半身不遂，跌打损伤，小儿惊风。
【用法用量】内服：煎汤，0.3～1两；或浸酒。
柔毛水杨梅
【来源】为蔷薇科植物柔毛水杨梅的全草及根。
【性味】①《云南中草药》："苦湿，凉。"②《陕西中草药》："甘辛，平。"
【功能主治】补脾肾，祛风湿，消痈肿。治腹泻，痢疾，白带，崩漏，风湿腰腿痛，跌打损伤，痈疽疮疡。
【用法用量】内服：煎汤，2～3钱。外用：捣敷。
葫芦藓
【来源】药材基源：为葫芦藓科植物葫芦藓的植物体。
【性味】淡；平
【归经】入肺、肝、肾三经
【功能主治】祛风除湿；止痛；止血。主风湿痹痛；鼻窦炎；跌打损伤；痨伤吐血
【用法用量】内服：煎汤，30-60g。外用：适量，捣敷。
钻地风
【来源】虎耳草科钻地风属植物全叶钻地风Schizophragmaintegrifolia（Franch.）Oliv.，以根及藤入药。夏秋采集，分别晒干。
【性味】淡，凉。
【功能主治】舒筋活络，祛风活血。用于风湿筋骨痛，四肢关节酸痛。
【用法用量】3～5钱。
大透骨草
【来源】为杜鹃花科植物尾叶越橘的全草。
【性味】微苦，微温。
【功能主治】祛风除湿，舒筋活络。治风湿关节疼痛。
【用法用量】内服：煎汤，3～5钱；或浸酒。外用：水煎洗。
红毛走马胎
【来源】为紫金牛科植物乳毛紫金牛的全株。
【性味】苦辛，凉。
【功能主治】清热利湿，活血和瘀。治痢疾，肝炎，胆囊炎，风湿，跌打劳伤，咳血，吐血，妇女痛经，血崩，小儿疳积，疮疖痈肿疼痛。
【用法用量】内服：煎汤，3～5钱；或泡酒。外用：研末调敷。
南蛇藤根
【来源】为卫矛种植物南蛇藤的根，8～10月采，洗净泥土，晒干。
【性味】《常用中草药配方》:"微辛，温，无毒。"
【功能主治】祛风胜湿，行气散血，消肿解毒。治风湿筋骨疼痛，跌打损伤，痧气呕吐腹痛，痈疽肿毒。
【用法用量】内服:煎汤，0.5～1两；或浸酒。外用:研末调敷或捣敷。
绵萆薢
【来源】本品为薯蓣科植物绵萆薢DioscoreaseptemlobaThunb.或福州薯蓣DioscoreafutschauensisUlineexR.kunth的干燥根茎。
【性味】苦，平。
【归经】归肾、胃经。
【功能主治】利湿去浊，祛风通痹。用于淋病白浊，白带过多，湿热疮毒，腰膝痹痛。
【用法用量】9～15g。
丁公藤
【来源】本品为旋花科植物丁公藤ErycibeobtusfoliaBenth.或光叶丁公藤Erycibesch-midtiiCraib的干燥藤茎。
【性味】辛，温；有小毒。
【归经】归肝、脾、胃经。
【功能主治】祛风除湿，消肿止痛。用于风湿痹痛，半身不遂，跌扑肿痛。
【用法用量】3～6g,用于配制酒剂，内服或外搽。
积雪草
【来源】本品为伞形科植物积雪草Centellaasiatica（L.）Urb.的干燥全草。
【性味】苦、辛，寒。
【归经】归肝、脾、肾经。
【功能主治】清热利湿，解毒消肿。用于湿热黄疸，中暑腹泻，砂淋血淋，痈肿疮毒，跌扑损伤。
【用法用量】15～30g；鲜品加倍。
发明内容
本发明旨在提供一种治疗颈椎炎、风湿关节炎的中药，通过选择合适的药材及其配比，达到安全有效治愈颈椎炎、风湿关节炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗颈椎炎、风湿关节炎中药，其特征在于，由以下重量配比的药材制备而成：小叶爬岩香10份、鸡树条3份、榕须3份、四念癀1份、半枫荷根1份、铁丝灵仙2份、岩陀1份、艾虎15份、小叶买麻藤0.5份、搜山虎6份、鸭儿芹1份、马尾千金草3份、井口边草20份、长管假茉莉4份、朝鲜当归10份、追风伞1份、柔毛水杨梅2份、葫芦藓30份、钻地风5份、大透骨草3份、红毛走马胎3份、南蛇藤根1份、绵萆薢15份、丁公藤6份、积雪草17份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年9月-2012年6月间共收集120例颈椎炎、风湿关节炎的门诊患者，年龄27-49岁，病程1-2年。随机分为：治疗组75例，空白组45例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次，疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，观察三个月未见反复。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。
无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率（%） | 不良反应例 |
| 治疗组 | 75 | 13(17.3%) | 47(62.7%) | 15(20.0%) | 80.0% | 0 |
| 空白组 | 45 | 0(0%) | 7(15.6%) | 38(84.4%) | 15.6% | 0 |
可见，本发明制得的药物能够安全有效治疗颈椎炎、风湿关节炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：小叶爬岩香10克、鸡树条3克、榕须3克、四念癀1克、半枫荷根1克、铁丝灵仙2克、岩陀1克、艾虎15克、小叶买麻藤0.5克、搜山虎6克、鸭儿芹1克、马尾千金草3克、井口边草20克、长管假茉莉4克、朝鲜当归10克、追风伞1克、柔毛水杨梅2克、葫芦藓30克、钻地风5克、大透骨草3克、红毛走马胎3克、南蛇藤根1克、绵萆薢15克、丁公藤6克、积雪草17克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗颈椎炎、风湿关节炎。口服，每日分早晚两次服用。
具体实施例2
称取：小叶爬岩香10克、鸡树条3克、榕须3克、四念癀1克、半枫荷根1克、铁丝灵仙2克、岩陀1克、艾虎15克、小叶买麻藤0.5克、搜山虎6克、鸭儿芹1克、马尾千金草3克、井口边草20克、长管假茉莉4克、朝鲜当归10克、追风伞1克、柔毛水杨梅2克、葫芦藓30克、钻地风5克、大透骨草3克、红毛走马胎3克、南蛇藤根1克、绵萆薢15克、丁公藤6克、积雪草17克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗颈椎炎、风湿关节炎。口服，每日分早晚两次服用。
具体实施例3
称取：小叶爬岩香10克、鸡树条3克、榕须3克、四念癀1克、半枫荷根1克、铁丝灵仙2克、岩陀1克、艾虎15克、小叶买麻藤0.5克、搜山虎6克、鸭儿芹1克、马尾千金草3克、井口边草20克、长管假茉莉4克、朝鲜当归10克、追风伞1克、柔毛水杨梅2克、葫芦藓30克、钻地风5克、大透骨草3克、红毛走马胎3克、南蛇藤根1克、绵萆薢15克、丁公藤6克、积雪草17克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗颈椎炎、风湿关节炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗颈椎炎、风湿关节炎的中药胶囊剂，其特征在于，其制备方法为：称取小叶爬岩香10克、鸡树条3克、榕须3克、四念癀1克、半枫荷根1克、铁丝灵仙2克、岩陀1克、艾虎15克、小叶买麻藤0.5克、搜山虎6克、鸭儿芹1克、马尾千金草3克、井口边草20克、长管假茉莉4克、朝鲜当归10克、追风伞1克、柔毛水杨梅2克、葫芦藓30克、钻地风5克、大透骨草3克、红毛走马胎3克、南蛇藤根1克、绵萆薢15克、丁公藤6克、积雪草17克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
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